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Conserved domains on  [gi|488310680|ref|WP_002380065|]
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MULTISPECIES: TDT family transporter [Enterococcus]

Protein Classification

TDT family transporter( domain architecture ID 10174716)

tellurite resistance/dicarboxylate (TDT) family transporter with similarity to potassium-tellurite resistance protein TehA which functions as an ion channel

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
11-306 9.55e-95

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


:

Pssm-ID: 187765  Cd Length: 293  Bit Score: 282.51  E-value: 9.55e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  11 KVPIPICGLILGIVSLGNLLYSLGYATIGTIYCVLGSLLMILVILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVF 90
Cdd:cd09325    1 KIPIPIAGLALGLASLGNLLELSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  91 LDRIFtnAAWINVLWIGAVILHFILMIYFVAVHIFPTKieLEHIYPSWFITFVGIGVIPNTSQLFI-NELGKIVFWVALF 169
Cdd:cd09325   81 LKPFF--PALAQLLWLLAIILHIILIIYFTYKRILKFN--LEHVFPSWFVVYVGIVVASVTAPAFGqPLLGQIAFWFGFV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 170 FYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIYGIVVVNLYKIMQVTFY 249
Cdd:cd09325  157 AYLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFY 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488310680 250 PSYAAFTFPLVISATALVKVKPLFAEKVGLTSLLNILSTFELLLAVAIVSYVFIRYC 306
Cdd:cd09325  237 PSFAAFTFPLVISATALKKTSTYLASYGLYLPILKYLALFEILIATVIVLYVLIRYL 293
 
Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
11-306 9.55e-95

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187765  Cd Length: 293  Bit Score: 282.51  E-value: 9.55e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  11 KVPIPICGLILGIVSLGNLLYSLGYATIGTIYCVLGSLLMILVILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVF 90
Cdd:cd09325    1 KIPIPIAGLALGLASLGNLLELSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  91 LDRIFtnAAWINVLWIGAVILHFILMIYFVAVHIFPTKieLEHIYPSWFITFVGIGVIPNTSQLFI-NELGKIVFWVALF 169
Cdd:cd09325   81 LKPFF--PALAQLLWLLAIILHIILIIYFTYKRILKFN--LEHVFPSWFVVYVGIVVASVTAPAFGqPLLGQIAFWFGFV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 170 FYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIYGIVVVNLYKIMQVTFY 249
Cdd:cd09325  157 AYLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFY 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488310680 250 PSYAAFTFPLVISATALVKVKPLFAEKVGLTSLLNILSTFELLLAVAIVSYVFIRYC 306
Cdd:cd09325  237 PSFAAFTFPLVISATALKKTSTYLASYGLYLPILKYLALFEILIATVIVLYVLIRYL 293
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-313 8.53e-61

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 196.61  E-value: 8.53e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   1 MVESAKKFLRKVPIPICGLILGIVSLGNLLYSL-----GYATIGTIY----CVLGSLLMILVILKIIFTMKHALSTLDDP 71
Cdd:COG1275    1 MSTAPRSRLRNLPPAWFALVMGTGGLGLAWRLAaallpGPAAIAEVLlalaALLFLVLLLLYLLKWLRYPAAVRADLRHP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  72 IIASVSPTFTMALMVICVFLDRIFTNAAWinVLWIGAVILHFILMIYFVAVHIFPTKIELEHIYPSWFITFVGIGVIPNT 151
Cdd:COG1275   81 VRGSFFPTIPMALLLLGTGLLPLAPALAL--VLWLLGVALHLALTVYFPYRLFTGEKFEIEHITPAWFIPVVGNIVVAVA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 152 SQLF--INELGKIVFWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILS 229
Cdd:COG1275  159 GALLgpLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 230 QCIYGIVVVNLYKIMQVTFYPSYAAFTFPLVISATALVKVKPLFAekvglTSLLNILSTFELLLAVAIVSYVFIRYCIFL 309
Cdd:COG1275  239 LWWLLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATG-----LPFLAVLALALLVLATLVWLYVLVRTLRAL 313

                 ....
gi 488310680 310 FQRE 313
Cdd:COG1275  314 ARGK 317
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
21-297 5.22e-13

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 68.42  E-value: 5.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   21 LGIVS--LGNLLYSLGYATIGTIYCVLGSLLMILV----ILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVFLDRI 94
Cdd:pfam03595  13 TGGLAllLHHLPYGRGLRTIGLILFILNLVLFLLLlllyLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIINGLVLV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   95 FTNAAWINVL-----WIGAVILHFILMIYfVAVHIFPTKIELEHIYPSWFITFVGIGVIP------NTSQLFINELGKIV 163
Cdd:pfam03595  93 PVPGPWLVTLawvlwWWIGVALALAFAVG-VPFLLFTRHHLLEAMTPAWLLPVVPLMVVAalgallAALLLPILVVSYLL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  164 FWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIY---------- 233
Cdd:pfam03595 172 WGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILPALTALAGEILYvvalllalfl 251
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488310680  234 -----------GIVVVNLYKIMQVTFYPSYAAFTFPLVISATALVKVKplfaeKVGLTSLLNILSTFELLLAVAI 297
Cdd:pfam03595 252 wgfglwwffiaALSVLSALRRGGLPFNLGWWAFTFPLGAFALATIELG-----KALDSPFFRVLGTILSVLLVLV 321
PRK10764 PRK10764
potassium-tellurite ethidium and proflavin transporter; Provisional
157-311 1.87e-03

potassium-tellurite ethidium and proflavin transporter; Provisional


Pssm-ID: 236756  Cd Length: 324  Bit Score: 39.55  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 157 NELGKIVFWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYIS-MGGHLymPLVVFLLILSQCIYGI 235
Cdd:PRK10764 162 HDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSvNGGEG--DTLAKMLFGYGLLQLL 239
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488310680 236 VVVNLYK-IMQVTFYPSYAAFTFplviSATALVKVKPLFAEKvGLTSLLNILSTFELLLAVAIVSYVFIRYCIFLFQ 311
Cdd:PRK10764 240 FLLRLMPwILSQGFNASFWSFSF----GVAALATTGLHLGHG-SDNGFFHTLAVPLFIFANFIIALLLLRTLALLMQ 311
 
Name Accession Description Interval E-value
TDT_C4-dicarb_trans cd09325
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ...
11-306 9.55e-95

C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187765  Cd Length: 293  Bit Score: 282.51  E-value: 9.55e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  11 KVPIPICGLILGIVSLGNLLYSLGYATIGTIYCVLGSLLMILVILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVF 90
Cdd:cd09325    1 KIPIPIAGLALGLASLGNLLELSYGSILRNICGLIALILLILLLLKIILFPKTLKEELKNPVIASVFPTFPMALMLLSTY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  91 LDRIFtnAAWINVLWIGAVILHFILMIYFVAVHIFPTKieLEHIYPSWFITFVGIGVIPNTSQLFI-NELGKIVFWVALF 169
Cdd:cd09325   81 LKPFF--PALAQLLWLLAIILHIILIIYFTYKRILKFN--LEHVFPSWFVVYVGIVVASVTAPAFGqPLLGQIAFWFGFV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 170 FYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIYGIVVVNLYKIMQVTFY 249
Cdd:cd09325  157 AYLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLPRLLKLPFY 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488310680 250 PSYAAFTFPLVISATALVKVKPLFAEKVGLTSLLNILSTFELLLAVAIVSYVFIRYC 306
Cdd:cd09325  237 PSFAAFTFPLVISATALKKTSTYLASYGLYLPILKYLALFEILIATVIVLYVLIRYL 293
TDT_TehA_like cd09322
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The ...
11-300 7.34e-61

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).


Pssm-ID: 187762  Cd Length: 289  Bit Score: 195.84  E-value: 7.34e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  11 KVPIPICGLILGIVSLGNLLYSLGYATIGTIYCVLGSLLMILVILKIIFTM----KHALSTLDDPIIASVSPTFTMALMV 86
Cdd:cd09322    1 LFPIVLGLLGLGLAWLGALLLLGLPSIVGEILGILALLLWLLLLLKYLLKLlrypEAVKAELRHPVRASFFATFSMSLML 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  87 ICVFLDRIFTNAAWinVLWIGAVILHFILMIYFVAVHIFPTKiELEHIYPSWFITFVGIGVIPNTS-QLFINELGKIVFW 165
Cdd:cd09322   81 LSIYLLPYSPLLAR--VLWILGAVLHLVFTLYFVSRWIRGGK-FLEHVTPSWFIPYVGNIVVPVTGpALGGPELGWFFFG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 166 VALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIYGIVVVNLYKIMQ 245
Cdd:cd09322  158 VGLIFWLVLLPLVLYRLIFHEPLPEPLRPTLAILLAPPSLGLAAYLALFGGPIDLFALILLGLALFLFLLLLRLLPRLLK 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488310680 246 VTFYPSYAAFTFPLVISATALVKVKPLFAEKVgltSLLNILSTFELLLAVAIVSY 300
Cdd:cd09322  238 LPFSPSWWAFTFPLAALAIALLKMAAYLGSGF---LQLLALVLLELLTAVILVLY 289
TehA COG1275
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
1-313 8.53e-61

Tellurite resistance protein TehA and related permeases [Defense mechanisms];


Pssm-ID: 440886  Cd Length: 323  Bit Score: 196.61  E-value: 8.53e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   1 MVESAKKFLRKVPIPICGLILGIVSLGNLLYSL-----GYATIGTIY----CVLGSLLMILVILKIIFTMKHALSTLDDP 71
Cdd:COG1275    1 MSTAPRSRLRNLPPAWFALVMGTGGLGLAWRLAaallpGPAAIAEVLlalaALLFLVLLLLYLLKWLRYPAAVRADLRHP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  72 IIASVSPTFTMALMVICVFLDRIFTNAAWinVLWIGAVILHFILMIYFVAVHIFPTKIELEHIYPSWFITFVGIGVIPNT 151
Cdd:COG1275   81 VRGSFFPTIPMALLLLGTGLLPLAPALAL--VLWLLGVALHLALTVYFPYRLFTGEKFEIEHITPAWFIPVVGNIVVAVA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 152 SQLF--INELGKIVFWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILS 229
Cdd:COG1275  159 GALLgpLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 230 QCIYGIVVVNLYKIMQVTFYPSYAAFTFPLVISATALVKVKPLFAekvglTSLLNILSTFELLLAVAIVSYVFIRYCIFL 309
Cdd:COG1275  239 LWWLLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATG-----LPFLAVLALALLVLATLVWLYVLVRTLRAL 313

                 ....
gi 488310680 310 FQRE 313
Cdd:COG1275  314 ARGK 317
TDT_SLAC1_like cd09323
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion ...
36-304 1.12e-16

Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); SLAC1 (Slow Anion Channel-Associated 1) is a plasma membrane protein, preferentially expressed in guard cells, which encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. It is essential for stomatal closure in response to carbon dioxide, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. In the Arabidopsis genome, SLAC1 is part of a gene family with five members and encodes a membrane protein that has ten putative transmembrane domains flanked by large N- and C-terminal domains. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic calcium ions and abscisic acid, but do not affect rapid (R-type) anion channel currents or calcium ion channel function.


Pssm-ID: 187763  Cd Length: 297  Bit Score: 78.74  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  36 ATIGTIYCVLGSLLMILV----ILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVFLDRIFTNAAwiNVLWIGAVIL 111
Cdd:cd09323   31 AAISEALGWLAVAVFVVLaalyALKILRYPEAVKAEFNHPVRINFFPAISISLLLLSIALLPYSPVLA--LALWIIGAVL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 112 HFILMIYFVAVHIFPTKIELEHIYPSWFITFVGIGVIPNT-SQLFINELGKIVFWVALFFYLLLLPILIKRITKSKEMPE 190
Cdd:cd09323  109 QLALTLYVVSRWISHRQFQIGHANPAWFIPVVGNLVVPIAgVPLGYAEVSWFFFSVGLFFWLVLFTIVFNRLIFHEPLPA 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 191 STIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVfLLILSQCIYGIVVVNLYKIMQVTFYPSYAAFTFPLVISATALVKvk 270
Cdd:cd09323  189 KLLPTLFILIAPPAVGFLAYLKLTGSLDAFARI-LYYIALFLFLLLLFQVRRFRKLPFFLSWWAYSFPLAALAIATLR-- 265
                        250       260       270
                 ....*....|....*....|....*....|....
gi 488310680 271 plFAEKVGlTSLLNILSTFELLLAVAIVSYVFIR 304
Cdd:cd09323  266 --MAELTG-SLFLQVLALVLLALLTLVVAVLLVR 296
SLAC1 pfam03595
Voltage-dependent anion channel; This family of transporters has ten alpha helical ...
21-297 5.22e-13

Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.


Pssm-ID: 460983  Cd Length: 321  Bit Score: 68.42  E-value: 5.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   21 LGIVS--LGNLLYSLGYATIGTIYCVLGSLLMILV----ILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVFLDRI 94
Cdd:pfam03595  13 TGGLAllLHHLPYGRGLRTIGLILFILNLVLFLLLlllyLLRFILYPEAVRAELRHPVESLFLGTFPMGFATIINGLVLV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680   95 FTNAAWINVL-----WIGAVILHFILMIYfVAVHIFPTKIELEHIYPSWFITFVGIGVIP------NTSQLFINELGKIV 163
Cdd:pfam03595  93 PVPGPWLVTLawvlwWWIGVALALAFAVG-VPFLLFTRHHLLEAMTPAWLLPVVPLMVVAalgallAALLLPILVVSYLL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  164 FWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISMGGHLYMPLVVFLLILSQCIY---------- 233
Cdd:pfam03595 172 WGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILPALTALAGEILYvvalllalfl 251
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488310680  234 -----------GIVVVNLYKIMQVTFYPSYAAFTFPLVISATALVKVKplfaeKVGLTSLLNILSTFELLLAVAI 297
Cdd:pfam03595 252 wgfglwwffiaALSVLSALRRGGLPFNLGWWAFTFPLGAFALATIELG-----KALDSPFFRVLGTILSVLLVLV 321
TDT_like_3 cd09321
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
48-304 5.14e-10

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).


Pssm-ID: 187761  Cd Length: 327  Bit Score: 59.63  E-value: 5.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  48 LLMILVILKIIFTMKHALSTLDDPIIASVSPTFTMALMVICVFLDRIFT---NAAWINVLWIGAVILHFILMIYFVAVHI 124
Cdd:cd09321   46 VLLVPWLLRWILYPKEALADLKHPVLSNFYPTMPIALLVLATNILIVGQgplGYSLALTLWILGSILIFIFSFIVSYIMF 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 125 FPTKIELEHIYPSWFITFVGIGVIPNTSQLFINELGK-----------IVFWVALFFYLLLLPILIKRITKSKEMPESTI 193
Cdd:cd09321  126 INEEIPIEHINPAWFIPPVGLIVIPLAGNFLIPHFPGawqesilvinlFGFGIGFFLFLFLLAIILHRLILHEPPPPELA 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 194 PLLTIMTAPGSLCLAGYISMGGHLYM----PLVVFLLILSQCIYG--------IVVVNLY--KIMQVTFYPSYAAFTFPL 259
Cdd:cd09321  206 PTFWINLAPIGAGVVALINLVKALPFagleNLVDLANIFALILWGfglwwlilAVLLTLYylKRGNLPFSLGWWAFIFPL 285
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 488310680 260 VISATALVKVKPLFaekvgLTSLLNILSTFELLLAVAIVSYVFIR 304
Cdd:cd09321  286 GAYTIATYLVAKVL-----NFSFLSGLGIFLYWLLLILWAITLFK 325
TDT_TehA cd09324
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ...
13-265 1.63e-04

Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.


Pssm-ID: 187764  Cd Length: 301  Bit Score: 42.64  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  13 PIPICGLILGIVSLGNLLYSLGY-----ATIGTIYCVLGS----LLMILVILKIIFTMKHALSTLDDPIIASVSPTFTMA 83
Cdd:cd09324    1 PVGYFGIVLGLAALGLAWRYAAQlwplpAIVGESLLALASvvwlLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680  84 LMVICVFLDRIFTNAAWinVLWIGAVILHFILMIYFVAVHIFPTKiELEHIYPSWFITFVGIGVIPNTSQLFI--NELGK 161
Cdd:cd09324   81 TMLVGIALYPYSRLLAE--VLIVLGIIGQLAFAAWRTGGLWQGGH-FPEATTPVLYLPTVAGNFVSASALAALgyHDLGM 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 162 IVFWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYISM-GGHLymPLVVFLLILSQCIYGIVVVNL 240
Cdd:cd09324  158 LFFGAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLnGGEV--DLLAKMLWGYGLLQLLFLLRL 235
                        250       260
                 ....*....|....*....|....*.
gi 488310680 241 YK-IMQVTFYPSYAAFTFPLVISATA 265
Cdd:cd09324  236 LPwIAEQGFSMGFWAFSFGLAAMATS 261
PRK10764 PRK10764
potassium-tellurite ethidium and proflavin transporter; Provisional
157-311 1.87e-03

potassium-tellurite ethidium and proflavin transporter; Provisional


Pssm-ID: 236756  Cd Length: 324  Bit Score: 39.55  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488310680 157 NELGKIVFWVALFFYLLLLPILIKRITKSKEMPESTIPLLTIMTAPGSLCLAGYIS-MGGHLymPLVVFLLILSQCIYGI 235
Cdd:PRK10764 162 HDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSvNGGEG--DTLAKMLFGYGLLQLL 239
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488310680 236 VVVNLYK-IMQVTFYPSYAAFTFplviSATALVKVKPLFAEKvGLTSLLNILSTFELLLAVAIVSYVFIRYCIFLFQ 311
Cdd:PRK10764 240 FLLRLMPwILSQGFNASFWSFSF----GVAALATTGLHLGHG-SDNGFFHTLAVPLFIFANFIIALLLLRTLALLMQ 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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