|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
12-390 |
1.11e-174 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 492.16 E-value: 1.11e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 12 AWIGCFFTGASISLVMPFIPVYVEQLG-TPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITM 90
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGvTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 91 GALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIIT 170
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 171 GVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLF 250
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 251 VSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 331 ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNF 390
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-392 |
1.47e-138 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 401.61 E-value: 1.47e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 3 IKWKQNLLVAWIGCFFTGASISLVMPFIPVYVEQLG-TPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIR 81
Cdd:PRK09874 10 INWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGvTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 82 AAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWF 161
Cdd:PRK09874 90 SALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 162 GMENVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSL 241
Cdd:PRK09874 170 GLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVREL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 242 SGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALM 321
Cdd:PRK09874 250 AGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALL 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488311938 322 PSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRK 392
Cdd:PRK09874 330 PAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRR 400
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-388 |
1.05e-61 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 203.19 E-value: 1.05e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGA 92
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQI----GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 93 LAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITG 171
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 172 VILFITTLLTIFLVKEDFQPVEKKD--LLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEnvl 249
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAvsAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 250 FVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLIS 329
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 330 KITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-354 |
7.65e-51 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 174.01 E-value: 7.65e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA----GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKmdhvSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEN 247
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR----PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VlfvSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTL 327
Cdd:COG2814 244 A---AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*..
gi 488311938 328 ISKITPTEGVSRVYSYNQMCSNFGQVL 354
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-380 |
1.13e-39 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 145.04 E-value: 1.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVA----GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIMRFMNGILSGYIPNAT-AMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILF 175
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAaTLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 176 ITTLLtIFLVKEDFQPVEKKDLLTTKEiFSKMDHVSVLIGLFVTTLIlQLGITSISPILTLYIRSLSGDtenvlfVSGLI 255
Cdd:cd17489 162 LALLL-VFLVKDPPPVAAEEAEAGTRA-FRRLVEKKVLPPALILFLA-SIAYGAISTFLPLYAAERGIS------NAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 256 VSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTE 335
Cdd:cd17489 233 FTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488311938 336 GVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-388 |
2.42e-39 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 143.49 E-value: 2.42e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 12 AWIGCFFTGASISLVMPFIPVYVEQLGTPkSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMG 91
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKL-GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 ALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITG 171
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 172 VILFITTLLTIFLVKedfqpvekkdllttkeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLfv 251
Cdd:cd17330 160 ALALLNLVLVLFFLP-------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI-- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 252 sGLIVSIAGVSAIISS-PTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17330 213 -GLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 331 ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-387 |
1.84e-36 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 136.53 E-value: 1.84e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDfqPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGdtEN 247
Cdd:cd17324 157 LAIAVLALLAALLLWRLLPSL--PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG--FS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VLFVSGLIVsIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTL 327
Cdd:cd17324 233 SSAIIGLLL-LFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 328 ISKITPtEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSF 387
Cdd:cd17324 312 VLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-392 |
1.01e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 132.31 E-value: 1.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMT 87
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 88 ITMGALAFVPNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV 166
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 167 FIITGVILFITTLLTIFLVK---EDFQPVEKKDLLTTKEIFsKMDHVSVLIGLFVTTLILQLGITSispILTLYIRSLSG 243
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRdppAGAAAAAKASLRDQLEAL-RDPRFWLLSLLYFGTFGSFIGFSS---WLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 DTenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRF-LLGFSTGALMP 322
Cdd:COG2223 238 LS---AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFlLLGLALGGGNG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488311938 323 SINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMV-GSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRK 392
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfGALLDATGSYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-388 |
3.43e-34 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.99 E-value: 3.43e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLvkedfqpvekkdllttkeifskmdhvsvLIGLFVTTLILQLGITSISPILTLYIRSLSgdten 247
Cdd:COG2271 168 LILGLPGLLLALLRFWL----------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLS----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 vLFVSGLIVSIAGVSAIISSPTLGKIGDRIG--NQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSIN 325
Cdd:COG2271 215 -LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488311938 326 TLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-356 |
2.03e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 127.53 E-value: 2.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYV-EQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMG 91
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 ALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIIT 170
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 171 GVILFITTLLTIFLVKEDF--QPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDtenv 248
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPEskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 249 LFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQK---VLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSIN 325
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
|
330 340 350
....*....|....*....|....*....|.
gi 488311938 326 TLISKITPTEGVSRVYSYNQMCSNFGQVLGP 356
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-388 |
1.04e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 120.75 E-value: 1.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 16 CFFTGASISLVMPFIPVYVEQLGTPKSQVELFsglaISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAF 95
Cdd:cd17474 8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLL----ITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 96 VPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWfGMENVFIITGVIL 174
Cdd:cd17474 84 SDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 175 FITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDH---VSVLIGLFVTTLILQLGITSISPILTLYIRSLSgdtenvlFV 251
Cdd:cd17474 163 PVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGrglLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISP-------II 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 252 SGLIVSIAGVSAIISSPTLGKI-GDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 331 ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17474 316 LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-385 |
1.38e-29 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 117.71 E-value: 1.38e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYV-EQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMG 91
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLhQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 ALAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQwFGMENVFIIT 170
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 171 GVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLf 250
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 251 vsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17329 239 --GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 331 ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGL 385
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-380 |
5.17e-28 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 113.48 E-value: 5.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGA 92
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLV----GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 93 LAFVP-----NVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV 166
Cdd:cd06173 81 LALLAllgslSLWLLLVLAFLLGIASAfFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 167 FIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHV---SVLIGLFVTTLILQLGITSISPILTLYIRSLSG 243
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLrrsPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 DTENVLfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPS 323
Cdd:cd06173 241 GGAAGY---GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488311938 324 INTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-370 |
3.09e-27 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 112.30 E-value: 3.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 1 MKIKWKQNLLVAwIGCFFTGASISLVMPFIPV-YVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKG----- 74
Cdd:COG2211 5 KKLSLKEKLAYG-LGDLGLNLAFGLLSAYLLYfYTDVLGLSAALV----GLILLVARLWDAITDPLIGALSDRTRtrwgr 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 75 RKIMMIRAAAGMTITMGALAFVPN------VYWLLIMRF-MNGILSGYIPNATAMIASQAPKEKN-GWALGTLSTGAIAG 146
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLlLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 147 TLIAPSIGGALAQWFGMEN------VFIITGVILFITTLLTIFLVKEDFQPVEKKdlLTTKEIFSKMDHVSVLIGLFVTT 220
Cdd:COG2211 160 GLLASVLPPPLVAAFGGDAalgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEK--VSLKESLKALLKNRPFLLLLLAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 221 LILQLGITSISPILTLYIRSLSGDTENVLfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV 300
Cdd:COG2211 238 LLFFLALALVAALLLYYFKYVLGLSAALV---GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 301 Q--TPFQLGVLRFLLGFSTGALMPSINTLISKITP---------TEGVsrVYSYNQMCSNFGQVLGPMVGSTVAHGFGYS 369
Cdd:COG2211 315 GpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgrrREGL--YFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
.
gi 488311938 370 S 370
Cdd:COG2211 393 A 393
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-387 |
6.10e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.12 E-value: 6.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 12 AWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMG 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL----GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 ALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQW--FGMENVFI 168
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 169 ITGVILFITTLLTIFLVKE-DFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEN 247
Cdd:cd06174 157 IAAALALLAAILLLLVVPDpPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLL-GGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINT 326
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 327 LISKITPTEGVSRVYSYNQMCSNFGQVLGP-MVGSTVAHGFGYSSVFLVTACFVLGNIGLSF 387
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPlLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-387 |
8.89e-24 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 101.09 E-value: 8.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 24 SLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLL 103
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQA----GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 104 IMRFMNGILSG-YIPNATAMiASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIItGVILFITTLLTI 182
Cdd:cd17478 89 LLVALAGIGSAaFHPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLIL-LIIPGLAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 183 FLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDtenvLFVSGLIVSIAGVS 262
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYS----LVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 263 AIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLrFLLGFSTGALMPSINTLISKITPtEGVSRVYS 342
Cdd:cd17478 243 GAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLP-GNVGLASG 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488311938 343 YNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSF 387
Cdd:cd17478 321 LMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-362 |
2.60e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 99.96 E-value: 2.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGAL 93
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAAAV----SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVI 173
Cdd:cd17504 79 AFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 174 LFITTLLTIFLVKEDFQpvekkdllttkeifskmdhVSVLIGLFVTTLILQLGITSISPILTLYIRS------LSGDTEn 247
Cdd:cd17504 159 AVLLAALVPLIDLRLLR-------------------RRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgfGLGITE- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 vlfvSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV-QTPFQLGVLRFLLGFSTGALMPSINT 326
Cdd:cd17504 219 ----AGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPN 294
|
330 340 350
....*....|....*....|....*....|....*.
gi 488311938 327 LISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTV 362
Cdd:cd17504 295 IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
216-388 |
3.10e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.96 E-value: 3.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTenvlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASV----AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVT 375
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170
....*....|...
gi 488311938 376 ACFVLGNIGLSFF 388
Cdd:cd17325 157 AALALLALVLALL 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-387 |
3.32e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 99.55 E-value: 3.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVYVEQLGTPKSQVELfsglAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGAL 93
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQW----VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGV 172
Cdd:cd17321 79 ALAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 173 ILFITTLLTIFLVkedfqpvekkdllttkeifskmdhvsvliGLFVTTLILQLGITSISPILTLYIRSLSGDTEnvlFVS 252
Cdd:cd17321 159 IGLVALLLARTFS-----------------------------GAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP---LQA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPF---QLGVLRFLLGFSTGALMPSINTLIS 329
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSsvwLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 330 KITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSF 387
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAF 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
9-380 |
1.26e-22 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 98.03 E-value: 1.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLgtpKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHF---VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQwFGMENVF 167
Cdd:cd17473 78 GGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEifsKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEn 247
Cdd:cd17473 157 LVYLLALPVLILVLLFLPEPARKSKSAASPGAATA---AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 vlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTL 327
Cdd:cd17473 233 --ALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488311938 328 ISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAH-GFGYSSVFLVTACFVL 380
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNlTGGLSGAFLILGVLAL 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-265 |
3.46e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.65 E-value: 3.46e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEN 247
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250
....*....|....*...
gi 488311938 248 VLFVSGLIVSIAGVSAII 265
Cdd:COG0477 252 LLLALLLLAALLLLLLLL 269
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
49-392 |
6.94e-22 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 96.76 E-value: 6.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMT-ITMGALAFVPNVYWLLIMRFMN----GILSGYIPNAtAMI 123
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGvLATAALFFVAPGGLWLGLLLFVlaniGFEGSLVFYN-AFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 124 ASQAPKEK------NGWALG----TLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKEDFQPVE 193
Cdd:COG2270 134 PDIATPEEigrvsgLGWALGylggVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 194 KKDLLTTKEIFS-------KMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVSGLIVSI-AGVSAII 265
Cdd:COG2270 214 APPRGAVRAGFRelrrtlrELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIvAALGALL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 266 ssptLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQ 345
Cdd:COG2270 294 ----FGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYA 369
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488311938 346 MCSNFGQVLGPMVGSTVAHGFGYS--SVFLVTACFVLGNIGLSFFNFRK 392
Cdd:COG2270 370 LSGKAASFLGPLLFGLVTQLTGSQrlGILSLIVFFVIGLVLLLRVKVPR 418
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
9-381 |
7.79e-22 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 96.17 E-value: 7.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQwFGMENVFI 168
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 169 ITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEI----FSKMDHVSVLIGLFVTTLILQLGITSISPILTLYirslsgd 244
Cdd:cd17388 160 VAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANpfgsLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLF------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 245 TENVLFVS----GLIVSIAGV-SAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFStGA 319
Cdd:cd17388 233 TEDRFDWSptmvGLSLAVFGLlHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GI 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 320 LMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVahgFGYSSVFLVTACFVLG 381
Cdd:cd17388 312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGI---FAASPATWPGLAWIIG 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
212-388 |
1.25e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.04 E-value: 1.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 212 VLIGLFVTTLILQLGITSISPILTLYIRSLSGDTenvlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSF 291
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASP----AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 292 ICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSV 371
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170
....*....|....*..
gi 488311938 372 FLVTACFVLGNIGLSFF 388
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-380 |
8.07e-21 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 92.66 E-value: 8.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFsgLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTG--LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTL----STGAIAGTLIAPSIGGALAQWFGM 163
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 164 ENVFIITGVILFITTLLTIFLVkedfqpvekkdllttkeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYIRSLSG 243
Cdd:cd17316 159 RILFLIGALPALLALLLRRRTL--------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 DTenvlfvSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIP--MAFVQTPFQLGVLRFLLGFSTGALM 321
Cdd:cd17316 213 AT------SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVW 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 322 PSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd17316 287 GALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
216-388 |
1.49e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 91.89 E-value: 1.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGdtenVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGG----SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVT 375
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170
....*....|...
gi 488311938 376 ACFVLGNIGLSFF 388
Cdd:cd17489 157 AVLALLALLLVFL 169
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-185 |
1.57e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.17 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIGCFFTGASISLVMPFIPVYVEQL-GTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGM 86
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 87 TITMGALAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMEN 165
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 488311938 166 VFIITGVILFITTLLTIFLV 185
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-388 |
3.06e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 85.31 E-value: 3.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIpvyVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17319 8 LFLAYVINYLDRVNISVAAPTI---MKDLGLSPTQY----GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGIL-SGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKedfqpvekkdllttkeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTen 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLR-------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFS-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 vLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQ---KVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSI 324
Cdd:cd17319 214 -LKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGarrLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVF 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 325 NTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMV-GSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17319 293 WSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
199-388 |
6.60e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 83.32 E-value: 6.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 199 TTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIG 278
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL----GWIVSAYLLGRAIGLLLFGRLGDRYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 279 NQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMV 358
Cdd:COG0477 78 RKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190
....*....|....*....|....*....|
gi 488311938 359 GSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:COG0477 158 GGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-381 |
7.02e-18 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 84.15 E-value: 7.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 15 GCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALA 94
Cdd:cd17477 4 SVALLGLGSGLLLPLLSLRLEREGVSTALI----GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 95 FVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQwfgMENVFIITGVI 173
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT---AGALPFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 174 LFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMdhvsvlIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsG 253
Cdd:cd17477 157 LLLLALVPLLLTRRAAPEIEEAESISLRRLLRIA------PLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQA----A 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 254 LIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV-QTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:cd17477 227 LLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGDRL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLG 381
Cdd:cd17477 307 PGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
14-388 |
8.75e-18 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 84.16 E-value: 8.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGAL 93
Cdd:cd17503 3 LGAFMAILDTTIVNVALPTIMGDLGASLDTV----QWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMRFMNGILSGY-IPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGV 172
Cdd:cd17503 79 GLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 173 ILFITTLLTiflvkedfqPVEKKDLLTTKeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEnvlFVS 252
Cdd:cd17503 159 IGILALLLA---------PLLDLRLFKDR----------NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA---FES 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV---QTPFQLGVLRFLLGFSTGALMPSINTLIS 329
Cdd:cd17503 217 GLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLAL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 330 KITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTV-----------------------AHGFGYSSVFLVTACFVLGNIGLS 386
Cdd:cd17503 297 NSLPPEQIGDATALFNTIRQLGGSIGTALLATLltnrtqfhhsrlsellaqqvqkqALIIAFNDAFLVSAILLLVGLLLA 376
|
..
gi 488311938 387 FF 388
Cdd:cd17503 377 LF 378
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
17-388 |
1.26e-17 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 83.40 E-value: 1.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADR--KGRKIMMIRAAAGMTITMGALA 94
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPTQI----GILIGIRPFVRFLSAPLWGALADRfgKRKALLLLSLLAAVLFFLSLFF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 95 FVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMEN---VFIITG 171
Cdd:cd17335 83 VAQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNytiAFYVFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 172 VILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIglfvTTLILQLGITSISPILTLYIRSLSGDTENVlfv 251
Cdd:cd17335 163 VLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLL----VAFLMGFGHGLIYSFLFWHLQDLGGSKTLI--- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 252 sGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKI 331
Cdd:cd17335 236 -GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 332 TPTEGVSRVYS-YNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17335 315 APPGLRATAQGlLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-396 |
2.63e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.59 E-value: 2.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQvelfSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:COG0738 18 FLWGFATALWGPLIPALKDAFGLSDAQ----AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNG---------WALGTLSTGAIAGTLIAPSIGGALAqwfgmeNVF 167
Cdd:COG0738 94 PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlnllhafFSLGALLGPLLGGLLILLGLSLSWH------LPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTL--ILQLGITSISPILTLYIRSLSGDT 245
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyvGAEGAIGDWLPLYLKDVLGLSEAT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 246 envlfvSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSIN 325
Cdd:COG0738 248 ------AALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488311938 326 TLISKITPTEGVSRVySYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRKVLNK 396
Cdd:COG0738 322 SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
22-388 |
3.34e-17 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 82.27 E-value: 3.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 22 SISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAF-VPNVY 100
Cdd:cd17490 11 SQYVYVPFLSPYAESLGASLSMI----GIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPW 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 101 WLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLL 180
Cdd:cd17490 87 GLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 181 TIFLVKEDfqPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVSGLIVSIAG 260
Cdd:cd17490 167 SLFIKEER--REKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 261 VSAIISSPtlgKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRV 340
Cdd:cd17490 245 LASLLSGT---LFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 488311938 341 YSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17490 322 MGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
14-385 |
3.45e-17 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 82.21 E-value: 3.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVY-VEQLGTPKSQVELFsglaISVTAFAAAIVAPIWGNLADRKG-RKIMMIRAAAGMTITMG 91
Cdd:cd17471 3 LATLLTGLAGAFVLPYLSLFlTEELGASPLQIGIF----MTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 ALAFVPNVYWLLIMRFM-NGILSGYIPNATAMI---ASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17471 79 LFAFLRNYWVLLLVGVVlLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVsvLIGLFVTTLIL---QLGITSISpiltLYI-RSLSG 243
Cdd:cd17471 159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL--LLLFAAFTLLFaanSMYIIAMP----LYVtNELGG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 DTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPS 323
Cdd:cd17471 233 SESWV----GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 324 INTLISKITPtEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGL 385
Cdd:cd17471 309 GISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
17-388 |
4.81e-17 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 81.88 E-value: 4.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRA---AAGMTITMGAL 93
Cdd:cd17385 9 FSSMICYSILAPFFPREAEKKGVSDTII----GLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGmfvSGGCTILFGFL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMRFMNGILSGyIPNATAMIASQAPKEKN-----GWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFI 168
Cdd:cd17385 85 DRVPDGTVFIALCFLVRIVEA-VGFAAFITASFAIIAKEfpnniATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 169 ITGVILFITTLLTIFLVkEDFQPVEKKdllTTKEIFSKMDHVSVLIGLFVTTLILqLGITSISPILTLYIRSLSGDTENV 248
Cdd:cd17385 164 VLGCLLLLTVPLNMFIL-PRYDDDPSP---KSGSMLKLLKIPSVLLLCLSIVSGS-VSLGFLDPTLSPHLRQFKLSPGQV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 249 lfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLL-GGLILSFICYI---PMAFVQTPFQL---GVLRFLLGFSTGA-L 320
Cdd:cd17385 239 ----GLMFLILAGSYAISAPLWGWLSDKKKIPKWLMvIGSIITGVGFLllgPAPLLPIKSELwmvIIGLVLLGLSLGAaL 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 321 MPSINTLISKIT--------PTEG-VSRVYSynqMCSNFGQVLGPMVGSTV--AHGFGYSSVFLVTACFVLGnIGLSFF 388
Cdd:cd17385 315 VPTFPELLNCAReygfpdnlSTYGlVSGLFN---AAFSLGAFIGPTLGGFLleRLGFEWAATIQAGLAFVVG-ILMSIY 389
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-388 |
1.15e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 80.78 E-value: 1.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVI----SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVY-----WLLIMRFMNGILSgyiPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGM 163
Cdd:cd17355 81 GLVLLALATSLWqlyllWGLLGGGGAGTLA---AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 164 ENVFIITGVILFITTLLTIFL---------VKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPIL 234
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLlrrrpadlaLRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 235 TLYIRSLSgdtenvlfVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQ-LGVLRFLL 313
Cdd:cd17355 238 ADRGISPA--------AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLaLLLFAALF 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488311938 314 GFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFG-YSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17355 310 GLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-376 |
2.50e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 79.55 E-value: 2.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 25 LVMPFI-PVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLL 103
Cdd:cd17365 16 AVMGFVaPALAQDWGLSPAQL----GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 104 IMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTI 182
Cdd:cd17365 92 LLRFLTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 183 flvkedfqpvekkdllttkeifskmdhVSVLIGL-FVTTLILQLGITSISPILtlyIRSLSGDTENvlfvSGLIVSIAGV 261
Cdd:cd17365 172 ---------------------------GTLLLWVtFFMGLLLVYLLNSWLPKL---MVEAGYSLSQ----ALTITLLLNI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 262 SAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV-QTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRV 340
Cdd:cd17365 218 GGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSpASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATG 297
|
330 340 350
....*....|....*....|....*....|....*..
gi 488311938 341 YSYNQMCSNFGQVLGPMVGST-VAHGFGYSSVFLVTA 376
Cdd:cd17365 298 VGWALGVGRLGAILGPLLGGLlLAAGLGPESVFLALA 334
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
216-388 |
6.21e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 6.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTENVLfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI---GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVT 375
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170
....*....|...
gi 488311938 376 ACFVLGNIGLSFF 388
Cdd:pfam07690 158 AILSLLAAVLLLL 170
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
212-380 |
2.02e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.83 E-value: 2.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 212 VLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSF 291
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 292 ICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSV 371
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
....*....
gi 488311938 372 FLVTACFVL 380
Cdd:COG2271 167 FLILGLPGL 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-380 |
3.74e-15 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 76.04 E-value: 3.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAisvtAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:cd17370 9 LFADISYEMARSILPLFLVVLGASAAAVGLIEGLA----EALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIM-----RFMNGILSgyiPNATAMIASQAPKEKNGWALG---TLST-GAIAGTLIApsIGGALAQWFGMENVF 167
Cdd:cd17370 85 AGSWQLVLLlrileRLGKGIRT---PPRDALLADATPPSGRGKAFGlhrALDTlGAVLGPLLA--ALLLYLLGGNYRTIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITtLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDhvSVLIGLFVTTLILQLGITSIsPILTLYIRSLSGDTen 247
Cdd:cd17370 160 LLAAIPALLA-LLILLFVVKEYPRPPKLRKKSKKTSLKKLP--KAFWLYLLAVALFALGNFSF-AFLILRAQELGLSA-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 vlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTL 327
Cdd:cd17370 234 --ALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488311938 328 ISKITPTEGVSRVYSYnqmcSNFGQVLGPMVGSTVA----HGFGYSSVFLVTACFVL 380
Cdd:cd17370 312 VADLVPAELRGTAYGL----FNTVVGIGWLLASLIAgylwDLISPSAAFLFSAVLAL 364
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
253-388 |
3.92e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 71.91 E-value: 3.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
26-388 |
7.68e-15 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 75.30 E-value: 7.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 26 VMPFIPVYVEQlgtpKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIM 105
Cdd:cd17384 19 VVPIIPDYLNE----NVRV----GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 106 RFMNGILSGYIPNA-TAMIASQAPKEKN-GWALGtLSTGAIA-GTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTI 182
Cdd:cd17384 91 RALQGVGSACSSVAgMGMLASLYPDDKErGKAMG-IALGGLAlGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 183 FLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLilqlGITSISPILTLYIRSLSGDTENVLfvsGLIVSIAGVS 262
Cdd:cd17384 170 FILQPSVKSEESEEGTPWKTLLKDPYILIAAGAICFSNS----GIAILEPCLPIWMMETMCPPKWQL---GTAFLPDSIG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 263 AIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTG----ALMPSINTLISkITPTEGVS 338
Cdd:cd17384 243 YLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGmvdsSMMPLLAYLVD-LRHSSVYG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 488311938 339 RVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17384 322 SVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLFF 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-185 |
1.31e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.55 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSqvelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGISNA------GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGIlsGY---IPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMEN 165
Cdd:cd17489 270 GLLLLSFAGSPWMLLLAAVLYGL--GFgllFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA 347
|
170 180
....*....|....*....|
gi 488311938 166 VFIITGVILFITTLLTIFLV 185
Cdd:cd17489 348 MFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
53-376 |
3.98e-14 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 73.02 E-value: 3.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 53 SVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMR----FMNGILSgyipnATAMIASQAP 128
Cdd:cd17331 42 TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvFMHAMQA-----AQMVVTDLTD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 129 KEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMD 208
Cdd:cd17331 117 PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 209 HVSVLI--------GLFVTTLILQLGITSISPILTLYIRSLSGDTENVLfvsGLIVSIAGV-SAIISSPTLGKIGDRIGN 279
Cdd:cd17331 197 LKEILRllrlpgvaFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEEN---GYLMSYAGVlGMVVQGLLVGPLTKRFGE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 280 QKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVG 359
Cdd:cd17331 274 RSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIG 353
|
330
....*....|....*..
gi 488311938 360 STVAHGFGYSSVFLVTA 376
Cdd:cd17331 354 GALLQAYGFPSFGLLGA 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
213-377 |
5.89e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 72.65 E-value: 5.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 213 LIGLFVTTLILQLGITSISPILTLYIRSLSGDTenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFI 292
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLS---ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 293 CYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAhGFGYSSVF 372
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLF 156
|
....*
gi 488311938 373 LVTAC 377
Cdd:cd17329 157 LAAAV 161
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-388 |
7.02e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.60 E-value: 7.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 5 WKQNLLVAWIGCFFTG----ASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMI 80
Cdd:COG2807 12 RRAGRWLLLLAIVLVAlnlrPAITSVGPLLPEIRADLGLSATQA----GLLTTLPLLAFGLFAPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 81 RAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQW 160
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 161 FGMENVFIITGVILFITTLLTIFLVKED-FQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLyiR 239
Cdd:COG2807 168 LGWRGALAVWALLALLALLLWLPLLRRRpAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD--A 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 240 SLSGDTenvlfvSGLIVSIAGVSAIISSPTLGKIGDRIGNQK-VLLGGLILSFICYIPMAFVQTPFQLGVLrFLLGFSTG 318
Cdd:COG2807 246 GLSAAT------AGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 319 ALMPSINTLISKITPT-EGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFG-YSSVFLVTACFVLGNIGLSFF 388
Cdd:COG2807 319 GLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLL 390
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
49-187 |
1.58e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 67.29 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGY-IPNATAMIASQA 127
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFaLVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 128 PKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKE 187
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-187 |
1.62e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 71.05 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIGCFFTGASISLVMPFIPVY-VEQLGTPKSQvelfSGLAISVTAFAAAIVAPIWGNLADR--KGRKIMMIRAAA 84
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQ----AGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 85 GMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGM 163
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....
gi 488311938 164 ENVFIITGVILFITTLLTIFLVKE 187
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
17-327 |
3.42e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.30 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVELfsglaiSVTAFAAAIVAP--IWGNLADRKGRKIMMIRAAAGMTITMGALA 94
Cdd:cd17320 9 ALGPLAIDMYLPALPAIARDLGASASAVQL------TLSAYLLGFALGqlLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 95 FVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVI 173
Cdd:cd17320 83 LASSIEQLLIARFLQGLgAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 174 LFITTLLTIFLVKE-----DFQPVEKKDLLTTKEIFSkmdHVSVLIGLFVTTLILQ--LGITSISPILTLYIRSLSGDTE 246
Cdd:cd17320 163 GLLLLLLVLLFLPEtlpeeKRKPLLSSLLRAYKRVLK---NRRFLGYALALGLSFAglFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 247 NVLFVSGLIVSIAGvsaiisSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLG-----FSTGALM 321
Cdd:cd17320 240 GLLFALNAIALILG------SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPlflifFGFGLIF 313
|
....*.
gi 488311938 322 PSINTL 327
Cdd:cd17320 314 PNATSL 319
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
6-378 |
7.38e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 69.57 E-value: 7.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 6 KQNLLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAAAIvapiWGNLADRKGRKIMMIRAAAG 85
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGAL----FGLLADKFGRKPLMMWSIVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 86 MTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGME 164
Cdd:PRK12307 93 YSVGTGLSGLASGVIMLTLSRFIVGMgMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 165 NVFIITgvilFITTLLTIFLVK-----------------EDFQPVEKKDLLTTKEIFSKMdHVSVLIGLFVTTLILqlgI 227
Cdd:PRK12307 173 AAFFVG----LLPVLLVIYIRArapeskeweeaklsgkgKHSQSAWSVFSLSMKGLFNRA-QFPLTLCVFIVLFSI---F 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 228 TSISPILTLYIRSLSGDTENVLFVSGLIvSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAF--VQTPFQ 305
Cdd:PRK12307 245 GANWPIFGLLPTYLAGEGFDTGVVSNLM-TAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRipQDNYLL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488311938 306 LGVLRFLLGFSTGALMPSINTLISKITPTE----GVSRVYSYNQMCSNFGQVLGPMVGSTVAHGfgySSVFLVTACF 378
Cdd:PRK12307 324 LGACLFGLMATNVGVGGLVPKFLYDYFPLEvrglGTGLIYNLAATSGTFNSMAATWLGITMGLG---AALTFIVAFW 397
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
23-390 |
1.40e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 68.40 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 23 ISLVMPFIPVYVEQL--GTPksqveLFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVY 100
Cdd:cd17472 12 MFLVLPVLSVYAKSLpgATP-----TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 101 WLLIMRFMNGilSGYIPNA-TAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTL 179
Cdd:cd17472 87 GLILGRALQG--SGAISSVvMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 180 LTIFLVKEDFQPVEKKDllTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVSGLIVSIA 259
Cdd:cd17472 165 ILLFFVPDPPKIVQISE--KEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 260 GVSAIISSptlgKIGDRIGNQK-VLLGGLILSFICYIPMAFVQTP---FQLGVLRFLLGFSTgaLMPSINTLISKITPTE 335
Cdd:cd17472 243 FILMVPFV----IYAEKKGKMKqVFVSSILLIAVGFLLLLFAATSlwlLIIGLIIFFIGFNL--LEALLPSLVSKIAPKE 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 336 GVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNF 390
Cdd:cd17472 317 YRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
13-388 |
2.40e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 67.73 E-value: 2.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGA 92
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADV----SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 93 LAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWAL----GTLSTGAIAGTLIAPSIGGALAQWFGMENVFI 168
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLnvlhGFFGLGALIGPLIATSLLTSELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 169 ITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVT--TLILQLGITSISPILTLYIRSLSgdte 246
Cdd:cd17333 158 LIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALflYVGAETAFSSWVPSYLVEKKHVS---- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 247 nvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINT 326
Cdd:cd17333 234 --DGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 327 LISKITPTEGVSrVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17333 312 LGISNLPYAKGK-GTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-389 |
3.13e-12 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 67.25 E-value: 3.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 22 SISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYW 101
Cdd:cd17390 11 GVSMILPLLSTHIRSLGASPTVI----GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 102 LLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWF-GMENVFIITGVILFITTLL 180
Cdd:cd17390 87 LFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFILNAGL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 181 TIFLVKEDFqpvekkDLLTTKEIFSkmdhVSVLI--GLFVTTLILQLGITSISpiltlyirslsgdtenvlfvSGLIVSI 258
Cdd:cd17390 167 VWFLLSKLW------DLLLVRFLMG----FSVLLfrSNFSLYLEERFDLSPKT--------------------IGYLISY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 259 AGVSAIISSPTLGKIGDRIGN--QKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEG 336
Cdd:cd17390 217 SGVLGALSGFLVGRILKLYKNneYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKE 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488311938 337 VSRVYSYNQMCSNFGQVLGPMVGStVAHGFGYSSVFLVTACFVLGNIGLSFFN 389
Cdd:cd17390 297 RGTLLGVGQSVTSLARILAPLLSG-LLQEFSVSGPGLLGAVLALAAILLMLAR 348
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-363 |
4.50e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 67.00 E-value: 4.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQA 127
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 128 PKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKM 207
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAI 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 208 D---------HVSVLI-----------------------GLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVsGLI 255
Cdd:TIGR00895 215 ApqmqaeaqsALPEQKstqgtkrsvfkalfqgktaritvLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATG-GAL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 256 VSIAGVSAIIsspTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTE 335
Cdd:TIGR00895 294 FNFGGVIGSI---IFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
|
330 340
....*....|....*....|....*...
gi 488311938 336 GVSRVYSYNQMCSNFGQVLGPMVGSTVA 363
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
225-388 |
4.72e-12 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 66.48 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 225 LGITSISPILTLYIRSLSGDTenvlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPF 304
Cdd:cd17390 10 FGVSMILPLLSTHIRSLGASP----TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 305 QLGVLRFLLGFSTGALMPSiNTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVA---HGFGYSSvFLVTACFVLG 381
Cdd:cd17390 86 LLFLSRIPLGIFKHTQSLC-KAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAetdGGFYYVA-LLCSAIFILN 163
|
....*..
gi 488311938 382 NIGLSFF 388
Cdd:cd17390 164 AGLVWFL 170
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-388 |
5.26e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 66.86 E-value: 5.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 48 SGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLI-MRFMNGILSG--YIpNATAMIA 124
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGVLGGIGAGigYI-TPVSTAV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 125 SQAPkEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVK---EDFQPVEKKDLLTTK 201
Cdd:cd17353 119 KWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRdppKGWVPPGVDPLANNA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 202 EI------FSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTenvLFVSGLIVSIAGVSAIISSPTLGKIGD 275
Cdd:cd17353 198 ENsprdytPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLD---AGIAALAVSILSIFNGGGRPFWGWLSD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 276 RIGNQKVLLGGLILSFICYIPMAFVQ-TPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVL 354
Cdd:cd17353 275 KIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLI 354
|
330 340 350
....*....|....*....|....*....|....
gi 488311938 355 GPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17353 355 GPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
17-392 |
7.49e-12 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 66.08 E-value: 7.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLgtPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKG--RKIMM----IRAAAGMTITM 90
Cdd:cd17326 9 FLSSLQFSIVLTSIWPYLQKI--DPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIvsilIAIVGNILYAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 91 GALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQ----------- 159
Cdd:cd17326 87 AEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPigypgyvigik 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 160 -WFGMENVFIITGVILFITTLLTIFLVKEDFqpvekkdllttkeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYI 238
Cdd:cd17326 167 lRFNMYTAPAWLMAILGIINIILILFFFKEV----------------------VCIFLFFVVLFIFANLETIGTPLTMDM 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 239 RSLSGdtENVLFVSGLIVSIAGVSAI-----ISSPTLGKIGDRIgnqkVLLGGLILSFICYIpmafVQTPFQL-GVLRFL 312
Cdd:cd17326 225 YGWTR--EEAVLYNGIILAVSGVLSVlvfllFKFLSLGLIDERK----ILLGGLILFFLGFV----VTLPWGItGVILFG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 313 LGFSTGALMpsINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRK 392
Cdd:cd17326 295 LGYPIGNVM--LYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKR 372
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
48-187 |
8.02e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.11 E-value: 8.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 48 SGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQ 126
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgEASYSPIAPTIIADL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 127 APKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV-FIITGVILFITTLLTIFLVKE 187
Cdd:cd17328 116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWaFRVTGVLGVLLAILLLLFVRE 177
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
4-380 |
1.68e-11 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 65.13 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 4 KWKQNLLVAWIGCFFTGASISLVMPFIPVyVEQLGTPKSQVELfsglAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAA 83
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPW-QDAFGYSSSQIAT----AASLSNLGMLLTQPILGFIADSFGPRPLMALAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 84 AGMTITMGALAFVPNVYWLLIMRFMN-GILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFG 162
Cdd:cd17314 76 IMVLAGYTYLSYVFNSFPLSYACFVFiGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 163 MENVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFS--KMDHVSVLIGLFVTTLILQLGITSISPILTLYIRS 240
Cdd:cd17314 156 LALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTmgEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 241 LSGDTENVLfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQ---KVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFST 317
Cdd:cd17314 236 LQLDAPSFV---TKLMSIYGLFNAFGRLLWGIVADFFGGRlstLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSY 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488311938 318 GALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTV-AHGFGYSSVFLVTACFVL 380
Cdd:cd17314 313 GGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAVIVF 376
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
49-385 |
4.23e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.86 E-value: 4.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQA 127
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 128 PKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGME---NVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTK--- 201
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiawRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFadr 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 202 ----EIFSK-MDHVSVLIGLFVTTliLQLGITSISPILTLYIRSLSGDTE------NVLFVSGLIVSIAgvsaiisspTL 270
Cdd:cd17371 197 pslrELFSPpLLRTTLLASLLATG--ALGGYYGITTWLPSYLTGERGLSFegsagyLVVTILGGFLGYL---------AG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 271 GKIGDRIGNQKVLLGGLILSFICYIPMAFV-QTPFQLGVLRFLLGFSTGALMPSINTLISKITPTE----GVSRVYSYNQ 345
Cdd:cd17371 266 GFLADRIGRRNNFALFALGSAISILLYFFLpLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAvratAQGFCYNVGR 345
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 488311938 346 MCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGL 385
Cdd:cd17371 346 IIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
9-189 |
8.09e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 62.98 E-value: 8.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGcFFTGASISLVMPFIPVYVEQLGTPKSQVELfsGLAISVTAFAAAIVapIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17323 2 FIISFLT-FVVTFGSSIYSPALPQIAEDFHVSEEVANL--GVSLFVLGFGLGPL--IWAPLSELYGRRPVYLVSLFIFVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGIL-SGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17323 77 FQIGCALAPNIAMLIILRFLQGFFgSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
|
170 180
....*....|....*....|..
gi 488311938 168 IITGVILFITTLLTIFLVKEDF 189
Cdd:cd17323 157 WFLAIISGFCLILIFLFLPIVL 178
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-184 |
1.95e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 2 KIKWKQNLLVAWIGCFFTGASISLVMPFIPVYV-EQLGTPKSQVELFSGlAISVTAFAAAIVAPIWGNladRKGRKIMMI 80
Cdd:cd06173 203 YLRRSPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLA-AFGVGALLGALLLGRLSK---RRRRGRLLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 81 RAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQ 159
Cdd:cd06173 279 IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
|
170 180
....*....|....*....|....*
gi 488311938 160 WFGMENVFIITGVILFITTLLTIFL 184
Cdd:cd06173 359 ALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
216-374 |
2.02e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.81 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVsgliVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWV----VNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-184 |
2.44e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.43 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGN-LADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQ 126
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTEL 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 127 APKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFL 184
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
9-356 |
2.59e-10 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 61.41 E-value: 2.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAAaivaPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17352 5 VFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSG----PLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWL-LIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17352 81 GLLLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVkedfqpvekkdllttkeIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYirslsGDTEN 247
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-----------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL-----GIDES 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VLFvsgLIVSIAGVSAIISSPTLGKIGDR--IGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSIN 325
Cdd:cd17352 219 DAA---FLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTP 295
|
330 340 350
....*....|....*....|....*....|.
gi 488311938 326 TLISKITPTEGVSRVYSYNQMCSNFGQVLGP 356
Cdd:cd17352 296 VILADLVGLEKLSNAYGLVLLFQGLAALVGP 326
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
17-374 |
2.67e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 61.49 E-value: 2.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAIsVTAFAAAivaPIWGNLADRKGRKIMMIRAAAGM-TITMGALAF 95
Cdd:pfam12832 9 FFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILP-LTRILAP---PIWGWLADRTGKRKAVVRLASILaAVLFLSVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 96 VP---NVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFgmENVFIITGV 172
Cdd:pfam12832 85 IPislTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYS--VGLLPSVLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 173 ILFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTenvlFVS 252
Cdd:pfam12832 163 YLFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASN----TLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMA-FVQTPFQLGVLRFLLGFSTGALMPSINTLISKI 331
Cdd:pfam12832 239 GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAfFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488311938 332 TPTEGVSRVYS-YNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:pfam12832 319 FPGSLQGTGQAlYSGLYFGLGGALGSLIGGQLWDLFGARFTFRA 362
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
213-380 |
3.17e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 3.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 213 LIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFI 292
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQV----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 293 CYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAhGFGYSSVF 372
Cdd:cd17474 77 GGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPF 155
|
....*...
gi 488311938 373 LVTACFVL 380
Cdd:cd17474 156 FLLAALIP 163
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
24-378 |
4.15e-10 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 61.10 E-value: 4.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 24 SLVMPFIPVYVEQLGTPKSqvelFSGLAISVTAFAAAIVAPIWGNLADRKG-----RKIMMIRAAAGMTITMG------- 91
Cdd:cd17313 16 ALENSYVPPILQTLGLSHA----LIGFVWTLGPILGLFVQPLVGSLSDRCNsrigrRRPFILVGAPLAALGLIlipnaad 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 92 -ALAFVPNVYWLLIMRFMNGILSGYIPNAT------AMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGAL------A 158
Cdd:cd17313 92 iGLALGDGPRTWALVLFVLGIVLLDFAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwfG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 159 QWFGMEN--VFIITGVILFITTLLTIFLVKE-DFQPVEKKD---------LLTTKEIFSKMDhvSVLIGLFVTTLILQLG 226
Cdd:cd17313 172 FALGGNLkvPFYIGAIILLVCVLVTLFFVKEpPLSPEAGEHsenpslgevLKSLLKLLKIMP--RSLLRLLLVIFFWWIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 227 ITSISPILTLYIRSLSGDTENVLF--------VSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMA 298
Cdd:cd17313 250 FFPFELFFTDYMGEEVYHGTSAASshygagvrMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 299 FVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVS---RVYSYNQMcSNFGQVLGPMVGSTVAHGFGYSSVFLVT 375
Cdd:cd17313 330 LVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGqgtDTGLLNLA-ISLAQILVSLLAGPIIDVKGYGTVFPVA 408
|
...
gi 488311938 376 ACF 378
Cdd:cd17313 409 AVA 411
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
26-184 |
5.28e-10 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 60.59 E-value: 5.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 26 VMPFipVYVEQLGTPKSQVelfsgLAISVTAFAAAIVA-PIWGNLADRKG-RKIMMIRAAAGMTITMGALAFVP----NV 99
Cdd:cd17337 230 FMPL--YFTDTGGFSTSQW-----LQIWGIIFLVNIFFnLIFGILGDKIGwRRTVRWFGGVGCAISTLLFYYVPqlfgHN 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 100 YWLLIMRFM-NGI-LSGYIPnATAMIASQAPKEKnGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFIT 177
Cdd:cd17337 303 YWAALIAAIlFGIgLAGFVP-LSALMPSLAPEHK-GAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLS 380
|
....*..
gi 488311938 178 TLLTIFL 184
Cdd:cd17337 381 AVLTLFL 387
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
271-376 |
5.41e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 60.26 E-value: 5.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 271 GKIGDRIGNQKVLLGGLIL-SFICYI-PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCS 348
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALwSLATLLtPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100
....*....|....*....|....*...
gi 488311938 349 NFGQVLGPMVGSTVAHGFGYSSVFLVTA 376
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFG 162
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-184 |
7.83e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.89 E-value: 7.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGtpkSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:cd17473 207 FLAMLLFYVIPIQLPFLLQERG---GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQW-FGMENVFIITGVIL 174
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLlPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtGGLSGAFLILGVLA 363
|
170
....*....|
gi 488311938 175 FITTLLTIFL 184
Cdd:cd17473 364 LVLAIVLLLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
9-380 |
1.00e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 59.56 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIpvyVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFL---QEDLHLSLAQV----GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17475 74 AALLMALVGSYPVLLVLLFLVGAGYGSVqPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 168 IITGVILFITTLLTIFLVKE--DFQPVEKKDLLTTKEIFSKMDHVSV-LIGLFVTTLI-LQLGITSISPILTLYIRSLSg 243
Cdd:cd17475 154 VVAGLVSILAAVLFWLFYREppAASAATESASTLLRSLKEVLRNRDVwLIAIAGALLVaPQFALLTFLLLFLHDHLGLS- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 dtenvLFVSGLIVSIAGVSAIISSPTLGKIGDRI--GNQKVLLGGL----ILSFICYIPMAFVQTPFQLGVLRFLLGFST 317
Cdd:cd17475 233 -----VVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITaaiaAAALLVLSLLSPGTPLWLLVLLLILLGLFA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488311938 318 GALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGP-MVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPpLFGLLVDATHSYAPAWLALALLLV 371
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
47-379 |
2.34e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 58.69 E-value: 2.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 47 FSGLAISVTAFAAAIVA-P----IWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNV----YW----LLIMRFMNGI-L 112
Cdd:cd17369 40 AAGTLAAFATFGVGFLArPlggvVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigILapilLVLLRLLQGLaL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 113 SGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV------------FIITGVILFITTLL 180
Cdd:cd17369 120 GGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAFlswgwripfllsAVLVAVGLYIRLRL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 181 TIFLVKEDFQPVEKKDLLTTKEIFSKmDHVSVLIGLFvttliLQLGITSISPILTLYIRSLSGDTENVLFVSGL-IVSIA 259
Cdd:cd17369 200 EETPVFRRAKEAGQVVRAPLVEVLRR-HWRALLLAIG-----LRLAENVLFYLFTTFALSYATQTLGVDRSTVLlAVLIA 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 260 GVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFV----QTPFQLGVLRFLLGFSTGALMPSINTLISKITPTE 335
Cdd:cd17369 274 SVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTR 353
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 336 ----GVSRVYsynqmcsNFGQVLG----PMVGSTVAHGFG---YSSVFLVTACFV 379
Cdd:cd17369 354 vrytGASLGY-------QLGAILGggfaPLIATALVAATGswwPVALYLAALAVI 401
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
17-374 |
3.39e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 58.05 E-value: 3.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIpvyVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:cd17312 16 YVCRKNFSVAKPPI---VEEIGLSKDDL----GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIMRFMNGILS--GYIPNATAMIASQAPKEKNGWaLGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVIL 174
Cdd:cd17312 89 TSLWFFAVLWGLNGLFQsmGWPPCVKLLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 175 FITTLLTIFLVKedfqpvekkdllttkeifskmDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTenvLFVSGL 254
Cdd:cd17312 168 LVVAIILFFFLR---------------------DSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYS---LIDAGW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 255 IVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLI----LSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17312 224 FSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIymllMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQ 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488311938 331 -ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:cd17312 304 dIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYF 348
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
9-185 |
4.24e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.62 E-value: 4.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAAAIVAPIWGNladRKGRKIMMIRAAAGMTI 88
Cdd:cd17490 197 LFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK---KLGERNTIIIGFLLLGA 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYWLLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVF 167
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGF 353
|
170
....*....|....*...
gi 488311938 168 IITGVILFITTLLTIFLV 185
Cdd:cd17490 354 FVIGVIALLAAILSLAYY 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
216-388 |
7.26e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.85 E-value: 7.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDtenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLG-GLILSFICY 294
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGAS----LSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIiGLLFTVLAS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 295 IPMAFVQTPFQLGVLRFLLGFsTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:cd17490 77 LIMILFPSPWGLLIARFLSGI-AAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLL 155
|
170
....*....|....
gi 488311938 375 TACFVLGNIGLSFF 388
Cdd:cd17490 156 AALAGVLGFILSLF 169
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-181 |
7.83e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.80 E-value: 7.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 11 VAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITM 90
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQA----ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 91 GALAFVPNVYW-LLIMRFMNGILSGYI-PNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFI 168
Cdd:cd17477 268 LLLPLVPGLPLaLLVLLFLWGGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFL 347
|
170
....*....|...
gi 488311938 169 ITGVILFITTLLT 181
Cdd:cd17477 348 FLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
216-391 |
8.42e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.67 E-value: 8.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL----GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGS--TVAHGFGYSSVFL 373
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGilASSLGFGWRAVFL 156
|
170
....*....|....*...
gi 488311938 374 VTACFVLGNIGLSFFNFR 391
Cdd:cd06174 157 IAAALALLAAILLLLVVP 174
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
242-369 |
9.96e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.90 E-value: 9.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 242 SGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVL---RFLLGFSTG 318
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVG 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488311938 319 ALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYS 369
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSD 168
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
216-387 |
2.02e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.64 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTenvlFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVST----ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGfGYSSVFLVT 375
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAA 155
|
170
....*....|..
gi 488311938 376 ACFVLGNIGLSF 387
Cdd:cd17477 156 VLLLLALVPLLL 167
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
253-394 |
3.60e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.88 E-value: 3.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRKVL 394
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW 182
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
8-325 |
3.71e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.62 E-value: 3.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIgCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAfaAAIVAPIWGNLADRKGRKIMMIRAAAGMT 87
Cdd:TIGR00886 2 NLFFSWF-GFFLSFLVWFAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLA--GAVLRIILGFLVDIFGPRYTTALSLLLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 88 ITMGALAFVPNVYW-LLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGT----LIAPSIGGALAQWFG 162
Cdd:TIGR00886 79 IPCLWAGLAVQSYSvLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGgvaqFVMPPIIGSLIFGGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 163 ME-------NVFIITGVILFITTLLTIFLVKEDF--QPVEKK-DLLTTKEIFsKMDHVSVLIGLFVTTLILQLGITSISP 232
Cdd:TIGR00886 159 QPahlawgwAFVIVPAGILLLPALLIFFVGADTPpgKPATGKlSFKEALKVF-GNRHTWILALLYSVTFGSFLGVSSIFA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 233 ILTLYIRSLSgdtenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFIC--YIPMAFV-QTPFQLGVL 309
Cdd:TIGR00886 238 MLFKDQFGLS------KVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGafLVVLGLVsDGSLAAFIV 311
|
330 340
....*....|....*....|....
gi 488311938 310 RFLLGF--------STGALMPSIN 325
Cdd:TIGR00886 312 LFVALFffagagngSTFALVPHIF 335
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
11-389 |
3.81e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 54.89 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 11 VAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVElfSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITM 90
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSL--QGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 91 GALAFVPNVYWLLIMRFMNGILSGYIPNATAM-IASQAPKEKNGwALGTLSTGAI-AGTLIAPSIGGALAQWFgmENVFI 168
Cdd:cd17315 79 LLSALAPNVWVLIVGRFLLGLGVGLASVLVPLyISEIAPAKIRG-ALGTLNQLMItFGILLAYLLGLALSLSP--PGWWR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 169 ITGVILFITTLLTIFLVkedFQPVEKKDLLttkeifskmdhVSVLIGLFvttliLQL-GITSISPILTLYIRSLSGDTEN 247
Cdd:cd17315 156 LMFALAAVPALLQLLLM---FFLPESRALL-----------VGVGLQLL-----QQLtGINAVMYYAPTIFKSAGGGTAS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VL--FVSGLIVSIAGVSAIISSptlgkigDRIGNQKVLLGGLILSFICYIPMAFVQTPFQ----------LGVLRFLLGF 315
Cdd:cd17315 217 ILasIIVGVVNLLATLVAIRLV-------DKVGRRPLLLIGFAGMAASLLLLAIAFLLPAlakaagwlalLGILLYIAAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 316 STGAlMPSINTLISKITPTEGVSRVYSYN---QMCSNF--GQVLGPMVGStvahgFGYSSVFLVTACFVLGNIGLSFFN 389
Cdd:cd17315 290 AMGA-GPVPWLLLSEIFPLRIRGKGMAIAtlvNWIFNFivGLTFLIMVST-----IGLAGVFIFFAAVCLLALVFVFFF 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
10-390 |
4.11e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 54.70 E-value: 4.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 10 LVAWIGCFFTGASISLVM--PFIPVYVEQLGTPKSQVELFSGLAIsvTAFAAAIVapIWGNLADRKGRKIMMIRAAAGMT 87
Cdd:TIGR00710 6 FALLLGCLSILGPLGIDMylPAFPEIAADLSTPASIVQMTLTLYL--LGFAAGQL--LWGPLSDRYGRRPVLLLGLFIFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 88 ITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV 166
Cdd:TIGR00710 82 LSSLGLALSNNIETLLVLRFVQAFgASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 167 FIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIF-SKMDHVSVLIGLFVTTLILQ--LGITSISPILTLYIRSLSG 243
Cdd:TIGR00710 162 FAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFlLLLKSKMFWGYALIYGASFGgfFAFFSGAPFVYIDIMGVSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 244 DTENVLFVsglivsIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTpfqLGVLRFLLGFSTGALMPS 323
Cdd:TIGR00710 242 SVFGLLFA------LNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAI---LGLGSWAMIIGPMMFVGI 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488311938 324 INTLISKITPTEGVSR----VYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNF 390
Cdd:TIGR00710 313 GNSMISSIAMAYALEDfphvAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYY 383
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
15-188 |
7.25e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.92 E-value: 7.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 15 GCFFTGASISLVMPFIpvyVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALA 94
Cdd:TIGR00881 6 AYYLVRKNFALAMPYL---VEEIGLSKTDL----GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 95 FVPNVYWLLIMRFMNGILSGY-IPNATAMIASQAPKEKNGWALGTLSTGA-IAGTLIAPSIGGALAQWFGMENVFIITGV 172
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGI 158
|
170
....*....|....*.
gi 488311938 173 ILFITTLLTIFLVKED 188
Cdd:TIGR00881 159 IAIIVSLICFLLLRDS 174
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
49-322 |
8.29e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 53.76 E-value: 8.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRK-----GRKIMMIRAAAGMTITMGALAFVPN-------VYWLLIMRFMNGILSGYI 116
Cdd:cd17332 38 GTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLFTTPDgsgtgklIYALITYILLDLLYTLVN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 117 PNATAMIA--SQAPKEKNGwALGTLSTGAIAGTLIAPSIGGALAQWFGMENV-------FIITGVILFITTLLTIFLVKE 187
Cdd:cd17332 118 IPYTALIPelTDDPEERTS-LTSWRMFFATIGGLLVTVLPPPLVAYFGGGNAsrgyfltALIIGIIGIILLLICFFGTRE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 188 DFQP-VEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIIS 266
Cdd:cd17332 197 RVVPpEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPW 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 267 SPTLgkigDRIGNQKVLLGGLILSFICYIPMAFVQTP--FQLGVLRFLLGFSTGALMP 322
Cdd:cd17332 277 PPLK----KRFGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIGYGGANL 330
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
51-393 |
9.96e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 54.16 E-value: 9.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 51 AISVTAFA-AAIVAPIW------GNLADR-KGRKIMMIRAAAGMTITMGALAF--VPNVYWLLIMRFMNGILSG-YIPNA 119
Cdd:PRK08633 45 QVILTAIVnALFLLPFLllsspaGFLADKfSKNRVIRIVKLFEVGLTLLIVLAyyLGWFWLAFAVTFLLGAQSAiYSPAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 120 TAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKEDF---------- 189
Cdd:PRK08633 125 YGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGLIfayrlpkvpa 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 190 ---QPVEKKDLLTTKEIFSKMDHVS-------VLIGLFVTTLILQLGITSISPiltlYIRSLSGDTENvlFVSGLIVSIA 259
Cdd:PRK08633 205 aapEVFDKKKYLFPKLLWRNLKLLRsdrvlwlAIIGLSYFWFISQLAQANFPA----YAKEVLGLDNT--FQVQYLLAAS 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 260 GVSAIISSPTLGKI-GDRIGNQKVLLGGLILsFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVS 338
Cdd:PRK08633 279 AIGIGIGSLLAGRLsGRHIELGLVPLGALGL-ALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELG 357
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488311938 339 RVYSYNQMCSNFGQVLGPMVGSTVAH-GFGYSSVFLVTAcfvLGNIGLSFFNFRKV 393
Cdd:PRK08633 358 KVLAANNFLQNVGMLLFLALTTLFSGlGLSPAGLFYLIA---LVTLIGTLYTLLLL 410
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
216-388 |
1.31e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIrslsgdTENVL---FVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVL-LGGLILSF 291
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFL------TEELGaspLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLiLLALLAGA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 292 ICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYN---QMCSNFGQVLGPMVGSTVAHGFGY 368
Cdd:cd17471 75 LGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNsvlRAAFSLAWVIGPPLAFLLLDVLGF 154
|
170 180
....*....|....*....|
gi 488311938 369 SSVFLVTACFVLGNIGLSFF 388
Cdd:cd17471 155 TGLFLLAALLYLVVALLVLF 174
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
22-195 |
1.38e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 52.99 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 22 SISLVMPFIPVYVEQLGTPKSQVElfsglaISVTAFAA--AIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNV 99
Cdd:PRK11102 6 AIDMYLPALPVIAADFGVSAGSVQ------MTLSAYILgfAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 100 YWLLIMRFMNGiLSGyipnATAMIASQA------PKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVI 173
Cdd:PRK11102 80 DQLIYMRFLHG-LAA----AAASVVINAlmrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALA 154
|
170 180
....*....|....*....|..
gi 488311938 174 LFITTLLTIFLVKEDFqPVEKK 195
Cdd:PRK11102 155 AILAAALVFFFIPETL-PKERR 175
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
253-374 |
1.59e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.74 E-value: 1.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
25-330 |
1.67e-07 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 52.81 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 25 LVMPFIPVYVEQLGTpksQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPnvYWLLI 104
Cdd:cd17387 18 LTTPMITVLHETFPQ---HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 105 MRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFL 184
Cdd:cd17387 93 MISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 185 VKEDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILT---------LYIRSLSG-DTENVlfvsGL 254
Cdd:cd17387 173 VPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPeagqyssffVYLKQVMGfEYEEV----AA 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488311938 255 IVSIAGVSAIISSPTLGKIGDR-IGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTgALMPSINTLISK 330
Cdd:cd17387 249 FIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSS-ITFPAISALVSR 324
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
216-388 |
2.69e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.22 E-value: 2.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGAT---PTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFVQTPFQLGVLRFLLGfsTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVT 375
Cdd:cd17472 78 LAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLIT 155
|
170
....*....|...
gi 488311938 376 ACFVLGNIGLSFF 388
Cdd:cd17472 156 AILSLVSLLILLF 168
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
14-180 |
3.28e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISlvMPFIPVYVEQLGTPKSQVELFSGLAisvtAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGAL 93
Cdd:cd17370 208 AVALFALGNFS--FAFLILRAQELGLSAALIPLLYALF----NLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMRFMNGILSGYIPNAT-AMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGV 172
Cdd:cd17370 282 ALGSSLWLLLLGFILWGLYMGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAV 361
|
....*...
gi 488311938 173 ILFITTLL 180
Cdd:cd17370 362 LALIALLL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
216-388 |
4.36e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 216 LFVTTLILQLGITSISPILTLYIRSLSGDTENVlfvsGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYI 295
Cdd:cd06173 4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLV----GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 296 PMAFV-----QTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSS 370
Cdd:cd06173 80 VLALLallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170
....*....|....*...
gi 488311938 371 VFLVTACFVLGNIGLSFF 388
Cdd:cd06173 160 AFAINALSFLLSALLLLF 177
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
28-381 |
4.49e-07 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 51.45 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 28 PFIPVYVEQLGTPkSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGA-LAFV-PNVYWLLIM 105
Cdd:cd17482 22 VYFKAVAAQGASP-VTSTALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIGVVSTAlLFFVtPGQWLLALL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 106 RFMNGIL--SGYIPNATAMIASQAPKEK------NGWALGTLStgaiAGTLIAPSIGG-ALAQWFGMENV------FIIT 170
Cdd:cd17482 101 LFILANIgfSGANVFYDAFLPDVASPERmdrvssLGYALGYIG----GGLLFAVNLVLiLGPDAFGLDTAeavrlsFLSV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 171 GVILFittLLTIFLvkedfqpvekKDLLTtkeifskmdhvsVLIGLFvttlILQLGITSISPILTLYIRSLSGDTENVLF 250
Cdd:cd17482 177 ALWWA---LFSIPL----------KQLLL------------FLIAYF----FYIDGVQTIIRMATIYGAEEGKLGSSALI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 251 VSGLIVSIAgvsAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISK 330
Cdd:cd17482 228 LALLLTQFV---AFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLVQGGIQALSRSLFGR 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488311938 331 ITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYS--SVFLVTACFVLG 381
Cdd:cd17482 305 LIPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTGSSryGILSLIVLFVIG 357
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
47-342 |
5.58e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 51.22 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 47 FSGLAISVTAFAAAIV-----APIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNV----YW----LLIMRFMNGI-L 112
Cdd:cd17368 36 FASLLLTFATFGVGFFmrpigAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigIAapllVLLARLLQGFaA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 113 SGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFL-------V 185
Cdd:cd17368 116 GGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLTAEALAEWGWRIPFFIGLLIIPLglwlrrsL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 186 KEDFQPVEKKDLLTTKEIFSkmdhvsvLIGLFVTTLILQLGITSISPILTLYIRSLSGDTEN-VLFVSG----LIVSIAG 260
Cdd:cd17368 196 EETEAFLERKARPTRRELFA-------LLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKtVLGLSArdsfLVTLLAG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 261 VSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIP----MAFVQTPFQL----GVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:cd17368 269 VANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPvfawLTAAPSFGRLllvlLVLSFFFGMYGGAMVVALVELFPVRV 348
|
330
....*....|
gi 488311938 333 PTEGVSRVYS 342
Cdd:cd17368 349 RSTGFSLVYA 358
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
9-315 |
6.19e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.10 E-value: 6.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAAAIVAPiwgnLADRKGRKIMMIRAAAGMTI 88
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGF----LCDRFGGRRVFIASLLLLLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 89 TMGALAFVPNVYW-LLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGT----LIAPSIGGALAQW--- 160
Cdd:cd17341 77 PLLALALAVSSYWgLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVavsqLLAPLIAGAIVFDggf 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 161 FGMENVFIITGVILFITTLLTIFLVKEdfQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRS 240
Cdd:cd17341 157 VGWRNAFFVPGILLAIAAVLVLLFGDD--LPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKT 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 241 LSGDTenvLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGF 315
Cdd:cd17341 235 RFGLP---LVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALF 306
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
47-186 |
7.18e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 7.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 47 FSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTIT--MGALAFVPNVYWLLIMRFMNGILSG-YIPNATAMI 123
Cdd:cd17380 35 DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLAtlLTPLLAYSSLPLLILSRILLGLGEGvHFPSMTSLF 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488311938 124 ASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVK 186
Cdd:cd17380 115 SRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
9-228 |
8.80e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 50.70 E-value: 8.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISlvmPFIPVYVEQLGTPKSqvelfSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIR----AAA 84
Cdd:cd06179 3 LCLAYFAQLFGVTLPA---AVLPFIVADLGPSSN-----STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGgnllGVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 85 GMTITMGAlafvPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQ--WFG 162
Cdd:cd06179 75 GSIVAGTA----KSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAG 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 163 MENVFIITGVILFITTLLTIFLvkedFQPVEKKDLL--TTKEIFSKMDHVSVLIGLFVTTLILqLGIT 228
Cdd:cd06179 151 WRWIFYINAIFNALALILLFFF----YHPPPRPQLHgsSTRQKLKRLDWVGLFLLIAGLVLFL-LGLS 213
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
49-204 |
1.10e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 50.35 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQA 127
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVgLGGALPNLIALTSEAV 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488311938 128 PKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKEDFQPVEKKDLLTTKEIF 204
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPV 209
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
49-302 |
1.25e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.40 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 49 GLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQA 127
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 128 PKEKNGWAlGTLSTGAIA-GTLIAPSIGGALAQWFGMENVFIITGVILFI----------------------TTLLTI-- 182
Cdd:TIGR00898 210 PKKQRAIV-GTLIQVFFSlGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLlswfvpesprwlisqgrieealKILQRIak 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 183 ----FLVKEDFQPVEKKDLLTTKEIFSKMDHVSVLIgLFVTTLILQLGITSISPI---LTLYIRSLSGDTENVLFVSGLI 255
Cdd:TIGR00898 289 ingkKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPN-LRKTTLCLMMLWFTTAFSyygLVLDLGNLGGNIYLDLFISGLV 367
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 488311938 256 VSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQT 302
Cdd:TIGR00898 368 ELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRT 414
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
13-355 |
1.48e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.48 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 13 WIGCFFTGASISLVMPFIPVYVEQLGTPKSQVELFSGLAISVTAFAaaivaPIWGNLADRKGRKIMMIRAAAGMTITMGA 92
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQ-----PIYGKLSDLFGRKWVLLIAIVIFELGSLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 93 LAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIIT- 170
Cdd:cd17502 77 CGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINl 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 171 ---GVILFITTLLTIFLVkedfqpvekkdllttkeifskmdhVSVLIGLFVTTLILQLgitsisPILTLYIRSLSGDTEN 247
Cdd:cd17502 157 pigGLALALLRTILLSSI------------------------FGFLFGGALFGLIYYL------PLYFQLVLGDSATKSG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 248 VLFVSGLIVSIAGvsAIISSPTLGKIGdriGNQKVLLGGLILSFICYIPMAFV---QTPFQLGVLRFLLGFSTGALMPSI 324
Cdd:cd17502 207 VRLLPLIIGLVIG--SIISGALISKTG---RYKPLIVIGTILMSVGAGLLTTLtldTSKWLLIGYLILLGLGLGIGFQQP 281
|
330 340 350
....*....|....*....|....*....|.
gi 488311938 325 NTLISKITPTEGVSRVYSYNQMCSNFGQVLG 355
Cdd:cd17502 282 LVAVQNAVPPADVGVATATNTFFRSLGGTLG 312
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
39-158 |
1.54e-06 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 49.97 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 39 TPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYIPN 118
Cdd:cd17389 57 ERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSL 136
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488311938 119 ATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALA 158
Cdd:cd17389 137 STAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFA 176
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
6-180 |
1.97e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.47 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 6 KQNLLVAWIGCFFTGASISLVMPFIPVYV-EQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAA 84
Cdd:cd17471 198 NRRLLLLFAAFTLLFAANSMYIIAMPLYVtNELGGSESWV----GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 85 GMTITMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGME 164
Cdd:cd17471 274 AGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYR 353
|
170
....*....|....*.
gi 488311938 165 NVFIITGVILFITTLL 180
Cdd:cd17471 354 AVFLVCAVLALLALVL 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
253-380 |
2.03e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGL 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-182 |
2.36e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.35 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIGCFFTGASISLVMPFIPVYVEQLGtpkSQVELFSGLAISVTAFAAAIVAPIWGNLADRK-GRKIMMIRAAAGM 86
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG---GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 87 TITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGAL-AQWFGME 164
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFgLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLT 360
|
170
....*....|....*...
gi 488311938 165 NVFIITGVILFITTLLTI 182
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
67-185 |
2.94e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 67 GNLADRKGRKIMMiraAAGMTITMGALAFVP-----NVYWLLIMRFMNGILSGYI-PNATAMIASQAP-KEKNGwaLGTL 139
Cdd:cd17318 77 GYLAEKYGAKRVL---GYSILITALLTLLTPlaargGYGALIVLRILQGLAQGVTfPAMHALWAKWAPpLERSR--LTSI 151
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 488311938 140 ST-GAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLV 185
Cdd:cd17318 152 AYsGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-151 |
4.35e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 2 KIKWKQNLLVAWIGCFFTGASISLVMPFIPVYVEQLGTPksqvELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIR 81
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS----ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488311938 82 AAAGMTITMGALAFVP---NVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAP 151
Cdd:pfam07690 271 ALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
250-371 |
1.01e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.18 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 250 FVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLIS 329
Cdd:cd17359 36 FLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIA 115
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488311938 330 KITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSV 371
Cdd:cd17359 116 EVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWL 157
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
16-186 |
1.39e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.81 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 16 CFFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAF 95
Cdd:cd17335 207 AFLMGFGHGLIYSFLFWHLQDLGGSKTLI----GLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSF 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 96 VPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLS-----TGAIAGTLiapsIGGALAQWFGMENVFII 169
Cdd:cd17335 283 LENPWLVLPIELLHGLtFALVWAAAVSYASAAAPPGLRATAQGLLQglyfgLGGGLGSL----IGGYLYEAFGARTTFRF 358
|
170
....*....|....*..
gi 488311938 170 TGVILFITTLLTIFLVK 186
Cdd:cd17335 359 FAIAALAGLLAFFLIQR 375
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
271-396 |
2.27e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 46.06 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 271 GKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNF 350
Cdd:PRK11102 47 GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTI 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488311938 351 GQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRKVLNK 396
Cdd:PRK11102 127 APLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPK 172
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-183 |
2.68e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 8 NLLVAWIGCFFTGASISLVMPFIPVYveqLGTPKSQVELFSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMT 87
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTY---LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 88 ITMGALAFVP--NVYWLLIMRFMNGILSGYIPNAT-AMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGME 164
Cdd:cd17316 255 ILALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|....*....
gi 488311938 165 NVFIITGVILFITTLLTIF 183
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
236-364 |
3.31e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 3.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 236 LYIRSLSGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGF 315
Cdd:cd17360 21 LYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGL 100
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 488311938 316 STGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAH 364
Cdd:cd17360 101 GVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSY 149
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
254-360 |
3.50e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 45.26 E-value: 3.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 254 LIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITP 333
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100
....*....|....*....|....*..
gi 488311938 334 TEGVSRVYSYNQMCSNFGQVLGPMVGS 360
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAY 135
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
60-354 |
3.75e-05 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 45.35 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 60 AIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAF------VPNVYWLLIMRFMNGILSGY---IPNATAMIASQAPKE 130
Cdd:cd17386 44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLivyfttVPSVWWFYLSAIPLALFGGFtafLSASFAYISDISSEK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 131 KNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKedfqpvekkdllttkeifskmdhv 210
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFLT------------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 211 svLIGLFVTTLILQLGITS-ISPILTLYIRS-LSGDTENVLFVSGLIVSIAGVSAIISSPTLGKigdrIGNQKVLLGGLI 288
Cdd:cd17386 180 --LLILLLLAAFLTIFVLSgESDVLYLFVLEkFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRC----LLKMSDSTLAML 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 289 LSFICYIPM---AFVQTPFQLGVLRfLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVL 354
Cdd:cd17386 254 GLASHILSSllfAFATNTWMMYLAA-VVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLV 321
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
231-379 |
4.75e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 45.26 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 231 SPILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLR 310
Cdd:cd17358 22 SPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGR 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 311 FLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAH------GFGYSSVFLVTACFV 379
Cdd:cd17358 102 FLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWrtlaliGAIPPVVFLILLFFI 176
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
264-380 |
5.73e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 5.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 264 IISSPTLGKIGDRIGNQKVLLGGLILSFIC--YIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVY 341
Cdd:cd17318 70 ILTQIPGGYLAEKYGAKRVLGYSILITALLtlLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149
|
90 100 110
....*....|....*....|....*....|....*....
gi 488311938 342 SYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVL 380
Cdd:cd17318 150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGL 188
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
219-394 |
6.03e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 219 TTLILQLGITSISPILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIISSPtlgkIGDRIGNQKVLLGGLILSFICYIPMA 298
Cdd:cd17323 7 LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 299 FVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVTACF 378
Cdd:cd17323 83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAII 162
|
170
....*....|....*.
gi 488311938 379 VLGNIGLSFFNFRKVL 394
Cdd:cd17323 163 SGFCLILIFLFLPIVL 178
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-388 |
7.31e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 7.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 47 FSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSgyipnATAMIAsq 126
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTS-----AGIFTV-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 127 apkeknGWALGTLSTG----AIAGTL--IAPSIGGALAQWFGMenvFIITGVIL-FITTLLTIFLVkedfqpvekkdllt 199
Cdd:cd17317 99 ------GFVLGMEIVGpkyrSFVGILfgLFWALGYMLLALLAY---LIRDWRWLqLAISLPGLLFL-------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 200 tkeIFSKMdhvsVLIGLFVTTLILqLGITSISPILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIIssptlgkIGDRIGN 279
Cdd:cd17317 156 ---LLLWW----LPRRTIIVGLIW-FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALL-------LLDRLGR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 280 QKVLLGGLILSFICYIPMAFV-QTPFQLGVLRFLLG-FSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPM 357
Cdd:cd17317 221 RWTLSGSLLLAGLACLVTALLpDDENTLALTLALVGkFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPF 300
|
330 340 350
....*....|....*....|....*....|.
gi 488311938 358 VGSTVAHGfGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17317 301 IVLLGKIG-PLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-235 |
7.80e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.56 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVYVEQLGTPKSQVELF-SGLAISVTAFAAaivapIWGNLADRKGRKIMMIRAAAGMTITMGA 92
Cdd:cd17476 5 GAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLaASYSLTVGTFIL-----IFGRLGDIYGHKKMFVIGSFWFAIWSLI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 93 LAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIAS--QAPKEKNgWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFII 169
Cdd:cd17476 80 AGFSPNFIFFIICRALQGLgPAFLLPNAMALLGRtyPPGPRKN-IVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488311938 170 TGVILFITTLLTIFLVKEDFQPVekkdLLTTKEIFSkmdhvSVLIGLFVTTLILQLgITSISPILT 235
Cdd:cd17476 159 LAILAAIVAVAAIFWTSPSFIAV----LLAVFLGWA-----SFGIWVFYATQYFQN-VRGYSPLLT 214
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
94-358 |
1.53e-04 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 43.65 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWLLIMR-FMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGV 172
Cdd:cd17428 86 AFAPNIYFLIFSYgIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVGA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 173 ----ILFITTLLTIFLVKedfqpvekkdllttkeifskmdhvsVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENV 248
Cdd:cd17428 166 lalnLLACGSLMRLFKNR-------------------------VFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIA 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 249 LFVsglIVSIAGVSAIISSPTLGKIGDR--IGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTG--ALMPSI 324
Cdd:cd17428 221 LIP---LVSIIGITTAIGKLILGVLADFkwVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGnwSIFPYV 297
|
250 260 270
....*....|....*....|....*....|....
gi 488311938 325 NTlisKITPTEGVSRVYSYNQMCSNFGQVLGPMV 358
Cdd:cd17428 298 TT---KTVGIEKLGHAYGILMFFAGLGNSLGPPI 328
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
51-391 |
1.70e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 43.58 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 51 AISVTAFAAAIVAPIWGNLADRkgRKIMM----IRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIAS 125
Cdd:pfam05977 53 AATLPIFLLSIPAGALADNFDR--RKIMLagqlLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIgTALMDPAWQASVPE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 126 QAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITgVILFITTLLTIFLVKEDfqpVEKKDLLTTKEI-- 203
Cdd:pfam05977 131 LVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALN-ALSYFAVIAALWRWKRA---APASPLPRERIFga 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 204 ------FSKMDHV--SVLIGLFvttlILQLGITSISPILTLYIRS-LSGDTenvlFVSGLIVSIAGVSAIISSPTLGKIG 274
Cdd:pfam05977 207 vraglrFTAMSRElrSVLVRAF----AFGLSASAVWALLPLVARDlLDGDA----IFYGILLGAVGVGAILGALSLPRLR 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 275 DRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVL 354
Cdd:pfam05977 279 ERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAA 358
|
330 340 350
....*....|....*....|....*....|....*..
gi 488311938 355 GPMVGSTVAHGFGYSSVFLVTACFVLGnIGLSFFNFR 391
Cdd:pfam05977 359 GSWLWGAVAEALSVTGALLGAAAALLA-GAAAGLRFR 394
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
17-388 |
1.77e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 43.26 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVmpFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKG-RKIMMIRAA--AGMTITMGAL 93
Cdd:cd17337 9 FMIGDGVEQG--FLSPYLVDLGFSEAQA----ALLFTVYGLTVAIASWLSGVLAELFGpRRVMLIGLIiwLVFEVLFLAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 94 AFVPNVYWL-LIMRFMNGIlsGYIPNATA---MIASQAPKEKNGWALG------TLSTGAIaGTLIA----PSIGGALAQ 159
Cdd:cd17337 83 GLPSHNYPLmLLTYGLRGF--GYPLFAYSflvWITYRTPAERLGSAVGwfwfafTGGLPVL-GSYLAsftiPVIGEIGTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 160 WFGMenVFIITGvilfitTLLTIFLVKEDF--QPVEKKDLLTTKEIFSK----MDHVSVLIGLFVTTlILQLGITSISPI 233
Cdd:cd17337 160 WLSL--VFVALG------GLIALFLVRDRTgeQPLANPSEEPLKELLSGitilFRNPKIAIGGIVRI-INTLSQFGFPVF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 234 LTLYIrslsgdTENVLFVSG---LIVSIAGVSAIISSPTLGKIGDRIGNQKVL------LGGLILSFICYIPMAFVQTPF 304
Cdd:cd17337 231 MPLYF------TDTGGFSTSqwlQIWGIIFLVNIFFNLIFGILGDKIGWRRTVrwfggvGCAISTLLFYYVPQLFGHNYW 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 305 QLGVLRFLLGFSTGALMPsINTLISKITPTEGVSRVYSYN--QMCSNFgqvLGPMVGSTVAHGFGYSSVFLVTACFVLGN 382
Cdd:cd17337 305 AALIAAILFGIGLAGFVP-LSALMPSLAPEHKGAAMSILNlgAGLSNF---VGPAIVTLFLGSFGAGGVVWIFAGLYLLS 380
|
....*.
gi 488311938 383 IGLSFF 388
Cdd:cd17337 381 AVLTLF 386
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
54-387 |
2.06e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 54 VTAFAAAIVApiwgnladRKGRKIMMIRAAAGMTI-TMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQ-APKEK 131
Cdd:cd06180 49 VGALLASFLR--------RRGRARRLIRGGLLLTVlLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHhATAAG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 132 NGWALGTLSTG-----AIAGTLIAPSIGGAL---AQWFGMENVFIITGVILFITTLltiflvkedfqpvEKKDLLTTKEI 203
Cdd:cd06180 121 RGHLIGLLFAGvglgiALSGLLVPAGLGGGLswrAGWLALALLSAVLLLLSFLLLR-------------RGPSAPTEASA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 204 FSKMDHVSVLIGLfVTTLILQLGITSIspILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVL 283
Cdd:cd06180 188 AESAPGLNRPLWR-LALAYGLFGFGYI--ITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRAL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 284 LGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGAlMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGS--- 360
Cdd:cd06180 265 AANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMA-ITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGwla 343
|
330 340
....*....|....*....|....*..
gi 488311938 361 TVAHGFGYSSVFLVTACFVLGNIGLSF 387
Cdd:cd06180 344 DATGGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
233-346 |
2.24e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.06 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 233 ILTLYIRSLSGDTENVLFVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFL 312
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110
....*....|....*....|....*....|....
gi 488311938 313 LGFSTGALMPSINTLISKITPTEGVSRVYSYNQM 346
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQS 130
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
37-205 |
2.39e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 37 LGTPKSQVelfsglAISVTAFAA--AIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGIlsG 114
Cdd:PRK11043 36 LQTSASAV------SASLSLFLAgfALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV--G 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 115 YIPNAT---AMIASQAPKEK------NGWALGTLSTGaiagtlIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLV 185
Cdd:PRK11043 108 VCSAAViwqALVIDRYPAQKanrvfaTIMPLVALSPA------LAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLK 181
|
170 180
....*....|....*....|
gi 488311938 186 KEDFQPVEKKDLLTTKEIFS 205
Cdd:PRK11043 182 PSKKARKQSQDALTFKQLLK 201
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
253-390 |
2.89e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 2.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWF 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVtACFVLGNIGLSFFNF 390
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV-AGLVSILAAVLFWLF 170
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
48-162 |
2.90e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 48 SGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYIP-NATAMIASQ 126
Cdd:cd17359 38 EGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMYIAEV 117
|
90 100 110
....*....|....*....|....*....|....*.
gi 488311938 127 APKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFG 162
Cdd:cd17359 118 APAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGG 153
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
9-184 |
2.96e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 9 LLVAWIGCFFTGASISLVMP--------FIPVYVEQLGTPKSQVElfSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMI 80
Cdd:cd17321 161 LVALLLARTFSGAVLAAFLLgaalggllFLLPLYLQGVLGYSPLQ--AGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 81 RAAAGMTITMGALAFVP--NVYWLLIMRFM-NGI-LSGYIPNATAMIASQAPKEKNGWALGTLST---------GAIAGT 147
Cdd:cd17321 239 AGLLLTAVGLLLLALLGadSSVWLLLPGLVlLGLgLGLFATPLTNAALSSVPKEKAGAASGILNTarqlggalgVALLGA 318
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 488311938 148 LIA------------PSIGGALAQWF--GMENVFIITGVILFITTLLTIFL 184
Cdd:cd17321 319 LLTaglsanlgdsgvAALLSAAAAAFaaGFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
252-374 |
4.36e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 252 SGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLIL----SFICyipmAFVQTPFQLGVLRFLLGFSTGALMPSINTL 327
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIfelgSLLC----GLAPNMTMLIVGRAIQGIGGGGLMSLAFII 107
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 488311938 328 ISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV 374
Cdd:cd17502 108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
10-177 |
5.46e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.79 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 10 LVAWIGCFFTGASISLVMPFIPVYVEQLGTP----KSQVELFSglaiSVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAG 85
Cdd:cd17358 5 FVANLGSFSFGIAVGWSSPALPSLMSDNSLSlpltVAQFSWFG----SLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 86 MTITMGALAFVPNVYWLLIMRFMNGILSGYIPNATAM-IASQAPKEKNGwALGTLSTGAIAGTLIAPSIGGALAQWFGME 164
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVyIAEIAPKNVRG-ALGSLNQLLVNIGILLGYVLGSFLPWRTLA 159
|
170
....*....|...
gi 488311938 165 NVFIITGVILFIT 177
Cdd:cd17358 160 LIGAIPPVVFLIL 172
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
63-364 |
5.49e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 41.51 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 63 APIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGI-LSGYIPNATAMIASQAPKEKNGWALGTLST 141
Cdd:cd17374 52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFaVSGISINTLILGTEWTTPRHRALAITLTSC 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 142 GAIAGTLIAPSIGGALAQWfgmENVFIITGVILFITTLLTIFLVKEdfqpvekkdllttkeifskmdhVSVLIGLFVTTL 221
Cdd:cd17374 132 FFSIGQMLLAGLAYAIRDW---RLLQLVVSVPFFLFFLYSWWLPKR----------------------TLILSFVWFANS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 222 ILQLGitsispiLTLYIRSLSGDtenvLFVSGLIVSIAGVSA-IISSPTLGKIGDRIgnqkVLLGGLILSFICYIPMAFV 300
Cdd:cd17374 187 FSYYG-------LSLDLQHLGLN----VFLLQFLFGAVEVPArCLALFLLNHMGRRI----SQAVLLLLAGLCILANIFV 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488311938 301 QTPFQ-LGVLRFLLG-FSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNFGQVLGPMVGSTVAH 364
Cdd:cd17374 252 PQEMQtLRTVLAVLGkGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVY 317
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
26-186 |
5.61e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 41.91 E-value: 5.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 26 VMPFIPVYVE---QLGTpksqveLFSGLAIsvtafAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWL 102
Cdd:cd17383 18 IVPIIPDYLNediAIGV------LFASKAI-----VQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 103 LIMRFMNGILSGYIPNA-TAMIASQAPKEKN-----GWALGTLSTGAiagtLIAPSIGGALAQWFGMENVFIITGVILFI 176
Cdd:cd17383 87 FFARSLQGVGSAFADTAgLAMIADRFTEEAErskalGIALAFISFGC----LVAPPFGGILYEFAGKEVPFLILAFVCLL 162
|
170
....*....|
gi 488311938 177 TTLLTIFLVK 186
Cdd:cd17383 163 DGLLLLLVMK 172
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
253-391 |
7.00e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKIT 332
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 333 PTEGVSRVYSYNQMCSNFGQVLGP-MVGSTVAHGFGYSSVFLVTACFVlgnIGLSFFNFR 391
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA---IIVSLICFL 169
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
50-184 |
7.30e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 7.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 50 LAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLL-----IMRFMNGILSGYIPNATAMIA 124
Cdd:cd17353 253 LAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFvlgvaLIGFCYGGGFALFPALTADFF 332
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 125 SQAPKEKNgwaLGTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFL 184
Cdd:cd17353 333 GTKNAGTN---YGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
65-187 |
7.94e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 41.43 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 65 IWGNLADRKGRKIMMIraaAGMTITM-GAL--AFVPNVYWLLIMRFMNGILSGYipnATAMIASQAPKEKNGWAL----G 137
Cdd:PRK11652 62 FYGPLSDRVGRRPVIL---VGMSIFIlGTLvaLFAHSLTVLIAASAIQGLGTGV---GGVMARTLPRDLYEGTQLrhanS 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488311938 138 TLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLVKE 187
Cdd:PRK11652 136 LLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPE 185
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
10-184 |
8.21e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.03 E-value: 8.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 10 LVAWIGCFFTGASISLVMPFIPVYVEQLGTPKSQvelfSGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTIT 89
Cdd:cd17365 174 LLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQ----ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVS 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 90 MGALAFVPNVYWLLIM------RFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGtliaPSIGGALAQW-FG 162
Cdd:cd17365 250 LALLGVSPASLVLLYVlvflagACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILG----PLLGGLLLAAgLG 325
|
170 180
....*....|....*....|..
gi 488311938 163 MENVFIITGVILFITTLLTIFL 184
Cdd:cd17365 326 PESVFLALAIPAALGALAVLLL 347
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
50-388 |
1.05e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 50 LAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAgMTITMGAL-AFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAP 128
Cdd:cd17372 38 LITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISAL-WTFYAGFLsAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 129 KEKNG---------WALGTLSTGAIAgTLIAPSIGgalaqWFGMENVFIITGVILFI-------TTLLTIFLVKEDFQPV 192
Cdd:cd17372 117 AKSRGtwmvlfsvfWTVGTIFEASLA-WLVMPRLG-----WRWLLAFSSVPSSLLLVfyrwtpkTTLLLWVIWFGNAFAY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 193 EKKDLLTTkEIFSKMD--HVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGdtenvlfVSGLIVSIAGVsaiissptl 270
Cdd:cd17372 191 YGVVLLTT-ELNNSHNvcGSKSDSDSGESPTEKQCRNSNDVDYRDVFIATFAE-------FPGLLISAAMI--------- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 271 gkigDRIGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSRVYSYNQMCSNF 350
Cdd:cd17372 254 ----DRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRI 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 488311938 351 GQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFF 388
Cdd:cd17372 330 GAILCPFIAQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
6-188 |
1.13e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 6 KQNLLVAWIG---CFFTGASISLVMPFIpvyVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMM--- 79
Cdd:cd17345 2 WQVFLGIFIGyagYYLVRNNFSLAQPYL---IEQYGLSKTEI----GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLaig 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 80 IRAAAGMTITMGALAFVPNVYWLL-IMRFMNGILSGY-IPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGAL 157
Cdd:cd17345 75 LILSAIINILIGFVPSATSSVGLMfILLFLNGWFQGMgWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLG 154
|
170 180 190
....*....|....*....|....*....|....
gi 488311938 158 AQWFGMENV---FIITGVILFITTLLTIFLVKED 188
Cdd:cd17345 155 LAIFGDGWWrgaFIFPAIIAIIVAVIVLFLGKDT 188
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
44-335 |
1.25e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.74 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 44 VELFSGLAI-SVTAFAAAIVAPIWGNLADRKGRKIMM-----IRAAAGMTI-------TMGALAFVpnvyWLLIMRFMNG 110
Cdd:cd17367 37 VALLSTAAVfAVGFLMRPIGGWLFGRLADRIGRRAALtlsvsLMAAGSLVIavtptyaTIGIWAPI----ILLLARLLQG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 111 I-LSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFGMENV--------FIITGVILFITTLLT 181
Cdd:cd17367 113 LsVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaawgwripFLLGGVLAVVVLWLR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 182 IFLVK-EDFQPVEKKDLLTTKEIFSKMDHVSVLIGLFVTTLILQLGITSISPILTLYIRSLSGDTENVLFvsgLIVSIAG 260
Cdd:cd17367 193 RGLEEtESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDAT---WITTAAL 269
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488311938 261 VSAIISSPTLGKIGDRIGNQKVLLGGLILsFICYIPMAFVQTPFQLGVLRFLLGFSTGALMPSINTLISKITPTE 335
Cdd:cd17367 270 LVFMLLQPLGGRLSDRIGRRPLLLFFGIG-GTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAE 343
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
17-392 |
1.74e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.02 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 17 FFTGASISLVMPFIPVYVEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADRKGRKIMMIRAAAGMTITMGALAFV 96
Cdd:cd17396 10 FVHGMGVIILAQNMSSLSEKWHTDVAGV----AYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 97 PNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQ---WFGMenVFIITGVI 173
Cdd:cd17396 86 PNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAAnnlWYGW--SFIVPAAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 174 LFITTLLTIFLVKEDFQPVEKKDLLTTKEIFSKMDHVSV-LIGLFVTTLILQLGITSISPILTLYIRSLSGDTENvlfVS 252
Cdd:cd17396 164 LVLNALLLLKLSFPPQTVTAANTKQKEIPVKREKPKFLIeGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEA---ES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDR-IGNQKVLLGGLILSFICYIPMAFVQTPFQLGVLRFLLGF-STGALMPSINTLISK 330
Cdd:cd17396 241 LKLISYYSMGSLVCVFITAVLLKRyVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFfAAGGVLQLGLTLMAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488311938 331 ITPTeGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLV-TACFVLGNIGLSFFNFRK 392
Cdd:cd17396 321 FFPK-GKGKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFdFGIALLGLLLAIFVFIRY 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-186 |
2.46e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.86 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 11 VAW-IGCFFTGASISL--VMPFIPVYVEQLGTPKSQvelfSGLAISVTAFAAAIVAPIWGNLADR-KGRKIMMIRAAAGM 86
Cdd:COG2807 216 LAWlLTLFFGLQSLLYyaVVAWLPPILRDAGLSAAT----AGLLLSLFQLAGIPGSLLVPLLADRlGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 87 TITMGALAFVPNVYWLLIMRFMNGILSGYIPNATAMIASQAPKEKN-GWALGTLSTGAIAGTLIAPSIGGALAQWFGMEN 165
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWT 371
|
170 180
....*....|....*....|..
gi 488311938 166 V-FIITGVILFITTLLTIFLVK 186
Cdd:COG2807 372 AaLLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
26-184 |
4.30e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.15 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 26 VMPFIPVYVeqlgtpkSQVELFSGLAISVTAF---AAAIVAPI-WGNLADR--KGRK-IMMIRAAAGMTITMGALAFVPN 98
Cdd:cd17345 250 ILDWAPTYL-------SEVKGFSKAQAMWAFSlfeWAAIPGTLlAGWLSDKlfKGRRaPTGIIFMILVIVALIVYWLAPN 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 99 VYWLLIMRFMNGILSgYIPnaTAMIASQA----PKEKNGWALG-TLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVI 173
Cdd:cd17345 323 VLVDLIALIALGFLI-YGP--VMLIGLQAlelvPKKAAGTAAGlTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLLAS 399
|
170
....*....|.
gi 488311938 174 LFITTLLTIFL 184
Cdd:cd17345 400 CILAIIFLALV 410
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
271-397 |
4.59e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 271 GKIGDRI-GNQKVLLGGLILSFICYIPMAFVQ-TPFQLGVLRFLLGFSTGALMPSINTLISKITPTEGVSR--VYSYNQM 346
Cdd:cd17346 61 GWLADKVlGARRTVFIGGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRdsGFSIFYM 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488311938 347 CSNFGQVLGPMVGSTVAHGFGYSSVFLVTACFVLGNIGLSFFNFRKVLNKK 397
Cdd:cd17346 141 GINLGAFLAPLLCGTLGDNYGYHYGFGLAAVGMLLGLLIFLLGRKKLLERK 191
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
59-185 |
5.17e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 38.94 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 59 AAIVAPIwGNLADRKGRKIMMIRAAAGMTITMGALAFVPNVYWLLIMRFMNGILSGYIPNAT-AMIASQAPKEKN-GWAL 136
Cdd:PRK14995 55 AGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATlAGIRATFTEEKQrNMAL 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 488311938 137 GTLSTGAIAGTLIAPSIGGALAQWFGMENVFIITGVILFITTLLTIFLV 185
Cdd:PRK14995 134 GVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
38-184 |
5.71e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 38.64 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 38 GTPKSQVEL-----FSGLAISVTafaaaivapIWGNLADRKGRKIMMiRAAAGMTITMGAL-AFVPNVYWLLIMRFMNGI 111
Cdd:cd17441 30 RLPSWQVALltsvvFIGMMLSSS---------LWGNISDQYGRKTGL-KISVLWTLYYGILsAFAPIYSWILVLRGLVGF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 112 LSGYIPNATAMIASQAPKEKNG---------WALGTLSTGAIAgTLIAPSIGgalaqWFGMenvFIITGVILFITTLLTI 182
Cdd:cd17441 100 GIGGVPQSVTLYAEFLPMKSRAkcillievfWALGTVFEVLLA-VFVMPTLG-----WRWL---LILSALPLLIFAVLCF 170
|
..
gi 488311938 183 FL 184
Cdd:cd17441 171 WL 172
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
253-355 |
5.74e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 253 GLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFICYIPMAF---VQTPFQLGVLRFLLGFSTGALMPSINTLIS 329
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLsksAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100
....*....|....*....|....*.
gi 488311938 330 KITPTEGVSRVYSYNQMCSNFGQVLG 355
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLG 157
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-184 |
5.96e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 5.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 14 IGCFFTGASISLVMPFIPVY-VEQLGTPKSQVelfsGLAISVTAFAAAIVAPIWGNLADR---KGRKIMMIRAAAGMTIT 89
Cdd:cd17319 186 LGYFGINYALYGLLTWLPTYlKQARGFSLKQV----GLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVG 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 90 MGALAFVPNVYWLLIMRFMNGILSG-YIPNATAMIASQAPKEKNGWALGTLSTGAIAGTLIAPSIGGALAQWFG-MENVF 167
Cdd:cd17319 262 LLLAYLTTSPVVAVILLSLAGFGIGaASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAF 341
|
170
....*....|....*..
gi 488311938 168 IITGVILFITTLLTIFL 184
Cdd:cd17319 342 LFLAAVALLAALLVLLL 358
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
250-385 |
9.33e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 37.94 E-value: 9.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488311938 250 FVSGLIVSIAGVSAIISSPTLGKIGDRIGNQKVLLGGLILSFI----CYIPMAFVQTP-FQLGVL---RFLLGFS----- 316
Cdd:PRK05122 51 FLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALsgllYLLAGLLAAWPvLSLLLLllgRLLLGIGeslag 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488311938 317 TGALMPSINTLISkitptEGVSRVYSYNQMCSNFGQVLGPMVGSTVAHGFGYSSVFLVtaCFVLGNIGL 385
Cdd:PRK05122 131 TGSILWGIGRVGA-----LHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLL--IMLLALLGL 192
|
|
| |
