|
Name |
Accession |
Description |
Interval |
E-value |
| PucG |
COG0075 |
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism ... |
10-402 |
1.93e-153 |
|
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439845 [Multi-domain] Cd Length: 376 Bit Score: 437.98 E-value: 1.93e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 10 RTIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQqAFAIDGTSRSGLEAGLFALIEPGDKVLV 89
Cdd:COG0075 1 RLLLTPGPTPVPPRVLRAMARPMIGHRDPEFVELMDEVRELLKKVFGTEND-VVILTGSGTGAMEAALANLVSPGDKVLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 90 PTYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKEH-QPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFV 168
Cdd:COG0075 80 LVNGAFGERWAEIAERYGAEVVVLEVPWGEAVDPEEVEEALAADpDIKAVAVVHNETSTGVLNPLEEIGALAKEHGALLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 169 VDMVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADylagryqkelglgadARNERFIQSNYLDLSQLE 248
Cdd:COG0075 160 VDAVSSLGGVPLDMDEWGIDVVVSGSQKCLMLPPGLAFVAVSERALE---------------AIEARKLPSYYLDLKLWL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 249 KYWGpERLNHHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDTKTPTVIPVVIPEGIDG 328
Cdd:COG0075 225 KYWE-KGQTPYTPPVSLLYALREALDLILEEGLENRFARHRRLAEALRAGLEALGLELFAEEEYRSPTVTAVRVPEGVDA 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488317948 329 EKVRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYsSREDNVLHFLSAFETVLKHQGYQFEGGSGSTHALAEYLN 402
Cdd:COG0075 304 AALRKRLKERYGIEIAGGLGPLKGKIFRIGHMGY-VNPEDVLRTLAALEEALRELGVPVELGAGVAAAQEVLAE 376
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
11-381 |
4.08e-115 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 340.04 E-value: 4.08e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 11 TIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQQAFAIDGTSRSGLEAGLFALIEPGDKVLVP 90
Cdd:cd06451 1 LLLIPGPSNVPPRVLKAMNRPMLGHRSPEFLALMDEILEGLRYVFQTENGLTFLLSGSGTGAMEAALSNLLEPGDKVLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 91 TYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKEHQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVD 170
Cdd:cd06451 81 VNGVFGDRWADMAERYGADVDVVEKPWGEAVSPEEIAEALEQHDIKAVTLTHNETSTGVLNPLEGIGALAKKHDALLIVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 171 MVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADYLAGRYQKELGlgadarnerfiqsnYLDLSQLEKY 250
Cdd:cd06451 161 AVSSLGGEPFRMDEWGVDVAYTGSQKALGAPPGLGPIAFSERALERIKKKTKPKGF--------------YFDLLLLLKY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 251 WGPERLNHHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDTKTPTVIPVVIPEGIDGEK 330
Cdd:cd06451 227 WGEGYSYPHTPPVNLLYALREALDLILEEGLENRWARHRRLAKALREGLEALGLKLLAKPELRSPTVTAVLVPEGVDGDE 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488317948 331 VRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYSSREDnVLHFLSAFETVLK 381
Cdd:cd06451 307 VVRRLMKRYNIEIAGGLGPTAGKVFRIGHMGEATRED-VLGVLSALEEALK 356
|
|
| PLN02409 |
PLN02409 |
serine--glyoxylate aminotransaminase |
9-401 |
3.26e-75 |
|
serine--glyoxylate aminotransaminase
Pssm-ID: 178031 [Multi-domain] Cd Length: 401 Bit Score: 239.27 E-value: 3.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 9 RRTIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQQAFAIDGTSRSGLEAGLFALIEPGDKVL 88
Cdd:PLN02409 9 RNHLFVPGPVNIPERVLRAMNRPNEDHRSPAFPALTKELLEDVKYIFKTKSGTPFIFPTTGTGAWESALTNTLSPGDKVV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 89 VPTYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKE---HQPKIVAMVHGETANAQMQPLDQIGAF--CREN 163
Cdd:PLN02409 89 SFRIGQFSLLWIDQMQRLNFDVDVVESPWGQGADLDILKSKLRQdtnHKIKAVCVVHNETSTGVTNDLAGVRKLldCAQH 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 164 EIFFVVDMVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADYLagryqkelglgADARNER--FIQSNY 241
Cdd:PLN02409 169 PALLLVDGVSSIGALDFRMDEWGVDVALTGSQKALSLPTGLGIVCASPKALEAS-----------KTAKSPRvfFDWADY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 242 LDLSQLEKYWGperlnhHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDT-KTPTVIPV 320
Cdd:PLN02409 238 LKFYKLGTYWP------YTPSIQLLYGLRAALDLIFEEGLENVIARHARLGEATRLAVEAWGLKLCTKKPEwRSDTVTAV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 321 VIPEGIDGEKVRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYSSrEDNVLHFLSAFETVLKHQGYQFEGGSGSTHAlAEY 400
Cdd:PLN02409 312 VVPEGIDSAEIVKNAWKKYNLSLGLGLNKVAGKVFRIGHLGNVN-ELQLLGALAGVEMVLKDVGYPVKLGSGVAAA-QAY 389
|
.
gi 488317948 401 L 401
Cdd:PLN02409 390 L 390
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
39-335 |
3.82e-22 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 96.55 E-value: 3.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 39 EFLQIMDEVREMIKVPFATKNQQA--FaIDGTSRSgLEA---GLFALIEPGDKVLVPTYGRFAYLLG--EICERARAEVI 111
Cdd:pfam00266 40 EATQAYEEAREKVAEFINAPSNDEiiF-TSGTTEA-INLvalSLGRSLKPGDEIVITEMEHHANLVPwqELAKRTGARVR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 112 YLEKDWLAPFEQTTVIEAIKEhQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKIDIAV 191
Cdd:pfam00266 118 VLPLDEDGLLDLDELEKLITP-KTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQAIGHRPIDVQKLGVDFLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 192 AGTQKCVSvPSGLSLITynqrVADYLAGRYQKELGLGAdarnerFIQSNYLDLSQLEKywGPERLNHHTEATTMIYGLHE 271
Cdd:pfam00266 197 FSGHKLYG-PTGIGVLY----GRRDLLEKMPPLLGGGG------MIETVSLQESTFAD--APWKFEAGTPNIAGIIGLGA 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488317948 272 GLRLLLQEGMENVYARHRKNNRILVESLQKM-GLEIFGklDTKTPTVIPVVIpEGIDGEKVRSLL 335
Cdd:pfam00266 264 ALEYLSEIGLEAIEKHEHELAQYLYERLLSLpGIRLYG--PERRASIISFNF-KGVHPHDVATLL 325
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PucG |
COG0075 |
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism ... |
10-402 |
1.93e-153 |
|
Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439845 [Multi-domain] Cd Length: 376 Bit Score: 437.98 E-value: 1.93e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 10 RTIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQqAFAIDGTSRSGLEAGLFALIEPGDKVLV 89
Cdd:COG0075 1 RLLLTPGPTPVPPRVLRAMARPMIGHRDPEFVELMDEVRELLKKVFGTEND-VVILTGSGTGAMEAALANLVSPGDKVLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 90 PTYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKEH-QPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFV 168
Cdd:COG0075 80 LVNGAFGERWAEIAERYGAEVVVLEVPWGEAVDPEEVEEALAADpDIKAVAVVHNETSTGVLNPLEEIGALAKEHGALLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 169 VDMVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADylagryqkelglgadARNERFIQSNYLDLSQLE 248
Cdd:COG0075 160 VDAVSSLGGVPLDMDEWGIDVVVSGSQKCLMLPPGLAFVAVSERALE---------------AIEARKLPSYYLDLKLWL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 249 KYWGpERLNHHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDTKTPTVIPVVIPEGIDG 328
Cdd:COG0075 225 KYWE-KGQTPYTPPVSLLYALREALDLILEEGLENRFARHRRLAEALRAGLEALGLELFAEEEYRSPTVTAVRVPEGVDA 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488317948 329 EKVRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYsSREDNVLHFLSAFETVLKHQGYQFEGGSGSTHALAEYLN 402
Cdd:COG0075 304 AALRKRLKERYGIEIAGGLGPLKGKIFRIGHMGY-VNPEDVLRTLAALEEALRELGVPVELGAGVAAAQEVLAE 376
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
11-381 |
4.08e-115 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 340.04 E-value: 4.08e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 11 TIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQQAFAIDGTSRSGLEAGLFALIEPGDKVLVP 90
Cdd:cd06451 1 LLLIPGPSNVPPRVLKAMNRPMLGHRSPEFLALMDEILEGLRYVFQTENGLTFLLSGSGTGAMEAALSNLLEPGDKVLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 91 TYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKEHQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVD 170
Cdd:cd06451 81 VNGVFGDRWADMAERYGADVDVVEKPWGEAVSPEEIAEALEQHDIKAVTLTHNETSTGVLNPLEGIGALAKKHDALLIVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 171 MVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADYLAGRYQKELGlgadarnerfiqsnYLDLSQLEKY 250
Cdd:cd06451 161 AVSSLGGEPFRMDEWGVDVAYTGSQKALGAPPGLGPIAFSERALERIKKKTKPKGF--------------YFDLLLLLKY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 251 WGPERLNHHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDTKTPTVIPVVIPEGIDGEK 330
Cdd:cd06451 227 WGEGYSYPHTPPVNLLYALREALDLILEEGLENRWARHRRLAKALREGLEALGLKLLAKPELRSPTVTAVLVPEGVDGDE 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488317948 331 VRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYSSREDnVLHFLSAFETVLK 381
Cdd:cd06451 307 VVRRLMKRYNIEIAGGLGPTAGKVFRIGHMGEATRED-VLGVLSALEEALK 356
|
|
| PLN02409 |
PLN02409 |
serine--glyoxylate aminotransaminase |
9-401 |
3.26e-75 |
|
serine--glyoxylate aminotransaminase
Pssm-ID: 178031 [Multi-domain] Cd Length: 401 Bit Score: 239.27 E-value: 3.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 9 RRTIMTPGPVEAHPSVLRQMGQPILGQFDPEFLQIMDEVREMIKVPFATKNQQAFAIDGTSRSGLEAGLFALIEPGDKVL 88
Cdd:PLN02409 9 RNHLFVPGPVNIPERVLRAMNRPNEDHRSPAFPALTKELLEDVKYIFKTKSGTPFIFPTTGTGAWESALTNTLSPGDKVV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 89 VPTYGRFAYLLGEICERARAEVIYLEKDWLAPFEQTTVIEAIKE---HQPKIVAMVHGETANAQMQPLDQIGAF--CREN 163
Cdd:PLN02409 89 SFRIGQFSLLWIDQMQRLNFDVDVVESPWGQGADLDILKSKLRQdtnHKIKAVCVVHNETSTGVTNDLAGVRKLldCAQH 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 164 EIFFVVDMVATYGGVETKVDDWKIDIAVAGTQKCVSVPSGLSLITYNQRVADYLagryqkelglgADARNER--FIQSNY 241
Cdd:PLN02409 169 PALLLVDGVSSIGALDFRMDEWGVDVALTGSQKALSLPTGLGIVCASPKALEAS-----------KTAKSPRvfFDWADY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 242 LDLSQLEKYWGperlnhHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKMGLEIFGKLDT-KTPTVIPV 320
Cdd:PLN02409 238 LKFYKLGTYWP------YTPSIQLLYGLRAALDLIFEEGLENVIARHARLGEATRLAVEAWGLKLCTKKPEwRSDTVTAV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 321 VIPEGIDGEKVRSLLLDHFKVEIASSFGDLKGKIWRVGNMGYSSrEDNVLHFLSAFETVLKHQGYQFEGGSGSTHAlAEY 400
Cdd:PLN02409 312 VVPEGIDSAEIVKNAWKKYNLSLGLGLNKVAGKVFRIGHLGNVN-ELQLLGALAGVEMVLKDVGYPVKLGSGVAAA-QAY 389
|
.
gi 488317948 401 L 401
Cdd:PLN02409 390 L 390
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
39-335 |
3.82e-22 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 96.55 E-value: 3.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 39 EFLQIMDEVREMIKVPFATKNQQA--FaIDGTSRSgLEA---GLFALIEPGDKVLVPTYGRFAYLLG--EICERARAEVI 111
Cdd:pfam00266 40 EATQAYEEAREKVAEFINAPSNDEiiF-TSGTTEA-INLvalSLGRSLKPGDEIVITEMEHHANLVPwqELAKRTGARVR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 112 YLEKDWLAPFEQTTVIEAIKEhQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKIDIAV 191
Cdd:pfam00266 118 VLPLDEDGLLDLDELEKLITP-KTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQAIGHRPIDVQKLGVDFLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 192 AGTQKCVSvPSGLSLITynqrVADYLAGRYQKELGLGAdarnerFIQSNYLDLSQLEKywGPERLNHHTEATTMIYGLHE 271
Cdd:pfam00266 197 FSGHKLYG-PTGIGVLY----GRRDLLEKMPPLLGGGG------MIETVSLQESTFAD--APWKFEAGTPNIAGIIGLGA 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488317948 272 GLRLLLQEGMENVYARHRKNNRILVESLQKM-GLEIFGklDTKTPTVIPVVIpEGIDGEKVRSLL 335
Cdd:pfam00266 264 ALEYLSEIGLEAIEKHEHELAQYLYERLLSLpGIRLYG--PERRASIISFNF-KGVHPHDVATLL 325
|
|
| PRK13479 |
PRK13479 |
2-aminoethylphosphonate--pyruvate transaminase; Provisional |
13-307 |
1.34e-17 |
|
2-aminoethylphosphonate--pyruvate transaminase; Provisional
Pssm-ID: 184076 [Multi-domain] Cd Length: 368 Bit Score: 83.42 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 13 MTPGPVEAHPSVLRQMgQPILGQFDPEFLQIMDEVRE-MIKVPFATKNQQAFAIDGTSRSGLEAGLFALIEPGDKVLVPT 91
Cdd:PRK13479 9 LTPGPLTTSRTVREAM-LRDWGSWDDDFNALTASVRAkLVAIATGEEGYTCVPLQGSGTFSVEAAIGSLVPRDGKVLVPD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 92 YGRFAYLLGEICER-ARAEVIYLEKDWLAPfeQTTVIEAIKEHQPKI--VAMVHGETANAQMQPLDQIGAFCRENEIFFV 168
Cdd:PRK13479 88 NGAYGARIAQIAEYlGIAHVVLDTGEDEPP--DAAEVEAALAADPRIthVALVHCETTTGILNPLDEIAAVAKRHGKRLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 169 VDMVATYGGVETKVDDWKIDIAVAGTQKCVS-VPsGLSLITYNQRVADYLAGRyqkelglgadARnerfiqSNYLDL--- 244
Cdd:PRK13479 166 VDAMSSFGAIPIDIAELGIDALISSANKCIEgVP-GFGFVIARRSELEACKGN----------SR------SLSLDLydq 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488317948 245 -SQLEKYwGPERLnhhTEATTMIYGLHEGLRLLLQE-GMENVYARHRKNNRILVESLQKMGLEIF 307
Cdd:PRK13479 229 wAYMEKT-GQWRF---TPPTHVVAAFYQALLELEEEgGVPARGARYANNQRTLVAGMRALGFEPL 289
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
75-338 |
5.76e-09 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 57.46 E-value: 5.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 75 AGLFALIEPGDKVLVPTYGRFAYLLG--EICERARAEVIYLEKDwlapFEQTTVIEAIKEH---QPKIVAMVHGETANAQ 149
Cdd:COG0520 94 AYGLGRLKPGDEILITEMEHHSNIVPwqELAERTGAEVRVIPLD----EDGELDLEALEALltpRTKLVAVTHVSNVTGT 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 150 MQPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKIDIAVAGTQKCVSvPSGLSLITYNQRVAD----YLAGryqkel 225
Cdd:COG0520 170 VNPVKEIAALAHAHGALVLVDGAQSVPHLPVDVQALGCDFYAFSGHKLYG-PTGIGVLYGKRELLEalppFLGG------ 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 226 glGADARNERFIQSNYLDLsqlekywgPERLnhhtEATTM----IYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQK 301
Cdd:COG0520 243 --GGMIEWVSFDGTTYADL--------PRRF----EAGTPniagAIGLGAAIDYLEAIGMEAIEARERELTAYALEGLAA 308
|
250 260 270
....*....|....*....|....*....|....*....
gi 488317948 302 M-GLEIFGKLDTKTPT-VIPVVIpEGIDGEKVRSLLLDH 338
Cdd:COG0520 309 IpGVRILGPADPEDRSgIVSFNV-DGVHPHDVAALLDDE 346
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
44-196 |
1.32e-07 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 50.84 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 44 MDEVREMIKVPFATKNQQAFAIDGtSRSGLEAGLFALIEPGDKVLVPTYGRFAYLlGEICERARAEVIYLEKD--WLAPF 121
Cdd:cd01494 2 LEELEEKLARLLQPGNDKAVFVPS-GTGANEAALLALLGPGDEVIVDANGHGSRY-WVAAELAGAKPVPVPVDdaGYGGL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488317948 122 EQTTVIEAIKEHQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVDMVATYGGV---ETKVDDWKIDIAVAGTQK 196
Cdd:cd01494 80 DVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASpapGVLIPEGGADVVTFSLHK 157
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
76-343 |
4.42e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 48.23 E-value: 4.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 76 GLFALIEPGDKVLVPTYGRFAYLLG--EICERARAEViylekDWLAPFEQTTV-IEAIKEH---QPKIVAMVHGETANAQ 149
Cdd:cd06453 80 GLGRANKPGDEIVTSVMEHHSNIVPwqQLAERTGAKL-----KVVPVDDDGQLdLEALEKLlteRTKLVAVTHVSNVLGT 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 150 MQPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKIDIAVAGTQKcVSVPSGLSLITYNQRVADylagRYQKELGLGA 229
Cdd:cd06453 155 INPVKEIGEIAHEAGVPVLVDGAQSAGHMPVDVQDLGCDFLAFSGHK-MLGPTGIGVLYGKEELLE----EMPPYGGGGE 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 230 DARNERFIQSNYLDLsqlekywgPERLNHHTEATTMIYGLHEGLRLLLQEGMENVYARHRKNNRILVESLQKM-GLEIFG 308
Cdd:cd06453 230 MIEEVSFEETTYADL--------PHKFEAGTPNIAGAIGLGAAIDYLEKIGMEAIAAHEHELTAYALERLSEIpGVRVYG 301
|
250 260 270
....*....|....*....|....*....|....*
gi 488317948 309 KLDTKTPtVIPVVIpEGIDGEKVrSLLLDHFKVEI 343
Cdd:cd06453 302 DAEDRAG-VVSFNL-EGIHPHDV-ATILDQYGIAV 333
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
69-172 |
2.02e-05 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 46.18 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 69 SRSGLEAGLFALIEPGDKVLVPTYGRFAYLlgEICERARAEVIYL----EKDWLAPFEQttvIEAIKEHQPKIVaMVH-- 142
Cdd:cd00609 68 AQEALSLLLRALLNPGDEVLVPDPTYPGYE--AAARLAGAEVVPVpldeEGGFLLDLEL---LEAAKTPKTKLL-YLNnp 141
|
90 100 110
....*....|....*....|....*....|....
gi 488317948 143 ----GETANAQmQpLDQIGAFCRENEIFFVVDMV 172
Cdd:cd00609 142 nnptGAVLSEE-E-LEELAELAKKHGILIISDEA 173
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
71-341 |
2.13e-05 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 46.14 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 71 SGLEAGLFALIEPGDKVLV--PTYGRFAyllgEICERARAEVI----YLEKDWLAPFEQttVIEAIKEhqpKIVAMVH-- 142
Cdd:pfam00155 74 ANIEALIFLLANPGDAILVpaPTYASYI----RIARLAGGEVVryplYDSNDFHLDFDA--LEAALKE---KPKVVLHts 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 143 -----GETANAQMqpLDQIGAFCRENEIFFVVDMVatYGGVetkvddwkidiaVAGTQKCVSVPSGLSlitynQRVADYL 217
Cdd:pfam00155 145 phnptGTVATLEE--LEKLLDLAKEHNILLLVDEA--YAGF------------VFGSPDAVATRALLA-----EGPNLLV 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 218 AGRYQKELGL-----GADARNERFIqsnyldlSQLEK----YWGPErlnhHTEATTMiyglhEGLR---LLLQEGMENVy 285
Cdd:pfam00155 204 VGSFSKAFGLagwrvGYILGNAAVI-------SQLRKlarpFYSST----HLQAAAA-----AALSdplLVASELEEMR- 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 488317948 286 ARHRKNNRILVESLQKMGLEIFGKlDTktpTVIPVVIPEGIDGEKVRSLLLDHFKV 341
Cdd:pfam00155 267 QRIKERRDYLRDGLQAAGLSVLPS-QA---GFFLLTGLDPETAKELAQVLLEEVGV 318
|
|
| PLN02651 |
PLN02651 |
cysteine desulfurase |
126-188 |
2.64e-05 |
|
cysteine desulfurase
Pssm-ID: 178257 [Multi-domain] Cd Length: 364 Bit Score: 45.80 E-value: 2.64e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488317948 126 VIEAIKEhQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKID 188
Cdd:PLN02651 131 LAAAIRP-DTALVSVMAVNNEIGVIQPVEEIGELCREKKVLFHTDAAQAVGKIPVDVDDLGVD 192
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
72-306 |
7.07e-05 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 44.74 E-value: 7.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 72 GLEAGLFALIEPGDKVLVP-----TYGRFAYLLGeicerarAEVIYL----EKDWLAPFEQttVIEAIKehqPKIVAMV- 141
Cdd:COG0436 102 ALALALLALLNPGDEVLVPdpgypSYRAAVRLAG-------GKPVPVpldeENGFLPDPEA--LEAAIT---PRTKAIVl 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 142 ------HGETANAQMqpLDQIGAFCRENEIFFVVDMV---ATYGGVET----KVDDWKidiavagtQKCVSVpSGLSLiT 208
Cdd:COG0436 170 nspnnpTGAVYSREE--LEALAELAREHDLLVISDEIyeeLVYDGAEHvsilSLPGLK--------DRTIVI-NSFSK-S 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 209 YN---QRVAdYLAGryqkelglgadarNERFIQS-----NYLDLSqlekywgperlnhhteATTMI-YGLHEGLRlLLQE 279
Cdd:COG0436 238 YAmtgWRIG-YAVG-------------PPELIAAllklqSNLTSC----------------APTPAqYAAAAALE-GPQD 286
|
250 260
....*....|....*....|....*..
gi 488317948 280 GMENVYARHRKNNRILVESLQKMGLEI 306
Cdd:COG0436 287 YVEEMRAEYRRRRDLLVEGLNEIGLSV 313
|
|
| NifS |
COG1104 |
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ... |
151-188 |
2.95e-04 |
|
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];
Pssm-ID: 440721 [Multi-domain] Cd Length: 381 Bit Score: 42.73 E-value: 2.95e-04
10 20 30
....*....|....*....|....*....|....*...
gi 488317948 151 QPLDQIGAFCRENEIFFVVDMVATYGGVETKVDDWKID 188
Cdd:COG1104 157 QPIAEIAEIAKEHGVLFHTDAVQAVGKIPVDVKELGVD 194
|
|
| PRK14012 |
PRK14012 |
IscS subfamily cysteine desulfurase; |
104-190 |
3.47e-04 |
|
IscS subfamily cysteine desulfurase;
Pssm-ID: 184450 [Multi-domain] Cd Length: 404 Bit Score: 42.62 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488317948 104 ERARAEVIYLE--KDWLAPFEQttVIEAIKEhQPKIVAMVHGETANAQMQPLDQIGAFCRENEIFFVVDMVATYGGVETK 181
Cdd:PRK14012 115 EREGFEVTYLDpqSNGIIDLEK--LEAAMRD-DTILVSIMHVNNEIGVIQDIAAIGEICRERGIIFHVDAAQSVGKVPID 191
|
....*....
gi 488317948 182 VDDWKIDIA 190
Cdd:PRK14012 192 LSKLKVDLM 200
|
|
|