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Conserved domains on  [gi|488318271|ref|WP_002387656|]
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MULTISPECIES: multidrug efflux SMR transporter [Enterococcus]

Protein Classification

DMT family transporter( domain architecture ID 10005269)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
11-93 6.79e-21

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


:

Pssm-ID: 441679  Cd Length: 105  Bit Score: 80.14  E-value: 6.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488318271  11 AWLKVIFGAFCEVIWVIGMKHS---TTWWEILGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLFHTP 87
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSdgfTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80


                 ....*.
gi 488318271  88 LGIGKV 93
Cdd:COG2076   81 LSLARL 86
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
11-93 6.79e-21

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 80.14  E-value: 6.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488318271  11 AWLKVIFGAFCEVIWVIGMKHS---TTWWEILGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLFHTP 87
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSdgfTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80


                 ....*.
gi 488318271  88 LGIGKV 93
Cdd:COG2076   81 LSLARL 86
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 11-93 5.47e-13

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 59.61  E-value: 5.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488318271   11 AWLKVIFGAFCEVIWVIGMKHS---TTWWEILGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLFHTP 87
Cdd:pfam00893   2 GWILLVLAIVLEVVGTSLLKYSegfTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGES 81


                  ....*.
gi 488318271   88 LGIGKV 93
Cdd:pfam00893  82 LSLKKV 87
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
11-84 8.84e-07

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 44.08  E-value: 8.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488318271  11 AWLKVIFGAFCEVIWVIGMKHSTTWWEI---LGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLF 84
Cdd:PRK11431   2 SWIILVIAGLLEVVWAVGLKYTHGFSRLtpsIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLL 78
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
11-93 6.79e-21

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 80.14  E-value: 6.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488318271  11 AWLKVIFGAFCEVIWVIGMKHS---TTWWEILGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLFHTP 87
Cdd:COG2076    1 AWLYLLLAGLLEVVWTLALKLSdgfTRLLPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEP 80


                 ....*.
gi 488318271  88 LGIGKV 93
Cdd:COG2076   81 LSLARL 86
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 11-93 5.47e-13

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 59.61  E-value: 5.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488318271   11 AWLKVIFGAFCEVIWVIGMKHS---TTWWEILGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLFHTP 87
Cdd:pfam00893   2 GWILLVLAIVLEVVGTSLLKYSegfTRLWPSILVIVGYGLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGES 81


                  ....*.
gi 488318271   88 LGIGKV 93
Cdd:pfam00893  82 LSLKKV 87
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
11-84 8.84e-07

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 44.08  E-value: 8.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488318271  11 AWLKVIFGAFCEVIWVIGMKHSTTWWEI---LGTVIAIFISFYALIKAGEELPVGTAYAVFVGLGSAGTIVTDHFLF 84
Cdd:PRK11431   2 SWIILVIAGLLEVVWAVGLKYTHGFSRLtpsIITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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