|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
13-382 |
2.70e-42 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 151.93 E-value: 2.70e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 13 IMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIG 92
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 93 IVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTIL 172
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 173 YLILVLVIYKNVPESPHKNPdiQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMM 252
Cdd:cd17324 163 ALLAALLLWRLLPSLPPKKP--GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 253 KLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQ 332
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 488368504 333 GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSI 382
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-350 |
2.38e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 143.58 E-value: 2.38e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 9 LITTIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFI 168
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 169 LTILYLILVLVIYKNVPESPHKNPDiqliKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSV 248
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARA----RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 249 SSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV 328
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330 340
....*....|....*....|...
gi 488368504 329 -KNNQGFFLSVNTFVLFLGTAIA 350
Cdd:COG2814 326 pPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-384 |
1.45e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 131.16 E-value: 1.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 15 FISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIV 94
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 95 HSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYL 174
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 175 ILVLVIYKNVPES--PHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMM 252
Cdd:cd17325 162 LALVLALLLLPEPrpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 253 KLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNN 331
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488368504 332 QGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
30-384 |
3.34e-29 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 116.52 E-value: 3.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGV 109
Cdd:cd17474 20 PILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYlNWQWVYFILTILYLILVLVIYKNVPESPH 189
Cdd:cd17474 100 GAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 190 KNPDIQLIKFFNNFKDFKDNLKV-----FYCLFISLTLLIMFISMYDILNEYVTSHQVGGdmsvssMMKLFGVIGMLLSL 264
Cdd:cd17474 179 KAKSSSATKLRDLKKALRGRGLLtflvsAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL------LFAGWSVLLALGSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 265 LAGRVSS-RIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKI-GVVVKNNQGFFLSVNTFV 342
Cdd:cd17474 253 FVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVtELAPEEERGTASSLYNFV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488368504 343 LFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17474 333 RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-351 |
3.67e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 3.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALP-LTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIG 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPaLPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 93 IVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTIL 172
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 173 YLILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLK--VFYCLFISLTLLIMFISMYDILNEYVTSHQVgGDMSVSS 250
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRdpVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 251 MMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIV---SIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVV 327
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 488368504 328 V-KNNQGFFLSVNTFVLFLGTAIAP 351
Cdd:pfam07690 320 ApKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-389 |
4.23e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 107.65 E-value: 4.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 9 LITTIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFI 168
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 169 LTILYLILVLviyknvpesphknpdiqlikffnnfkdfkdnLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSV 248
Cdd:COG2271 170 LGLPGLLLAL-------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 249 SSMMKLFGVIGMLLSLLAGRVSSRIG--IKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGV 326
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488368504 327 VV-KNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMPGDQR 389
Cdd:COG2271 299 LFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-380 |
5.13e-26 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 107.66 E-value: 5.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:cd17320 19 LPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 109 VFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESP 188
Cdd:cd17320 99 LGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 189 HKNPDIQLIKFF--NNFKDFKDNLKVFYCLFISLTLLIMFIsmYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLL-SLL 265
Cdd:cd17320 179 PEEKRKPLLSSLlrAYKRVLKNRRFLGYALALGLSFAGLFA--YLAAAPFIYIEQLGLSPAQFGLLFALNAIALILgSLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 266 AGRVSSRIGIKRLLTIALTTCIVSIILMGVTT-----NIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQGFFLSVNT 340
Cdd:cd17320 257 NGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488368504 341 FVLFLGTAIAPILM--LFVGELSNFFLQFLMIAIVGLIALVV 380
Cdd:cd17320 337 FLQFLIGALAGALVglLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-385 |
2.04e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.42 E-value: 2.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGV 109
Cdd:COG2223 26 VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIY---KNVPE 186
Cdd:COG2223 106 GGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWlflRDPPA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 187 SPHKNPDIQLIKFFNNFKDfKDNLKVFYCLFISLTLLIMFISmydILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLA 266
Cdd:COG2223 186 GAAAAAKASLRDQLEALRD-PRFWLLSLLYFGTFGSFIGFSS---WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 267 GRVSSRIGIKRLLTIALTTCIVSIILMGVTT-NIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNNQGFFLSVNTFVLF 344
Cdd:COG2223 262 GWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGG 341
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488368504 345 LGTAIAPILMLFVGELSNFFLQ-FLMIAIVGLIALVVSIFMP 385
Cdd:COG2223 342 LGGFLGPLLFGALLDATGSYTAaFLVFAVLALVALVLTLLLY 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-385 |
5.80e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 101.89 E-value: 5.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 21 VMASLYTALPltaTFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVL 100
Cdd:cd17504 11 VETMLSPALP---TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 101 LILRALQGVFAASFsPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVI 180
Cdd:cd17504 88 IAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 181 yknvpesphknPDIQLIKFFNnfkdfKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKL-FGVIG 259
Cdd:cd17504 167 -----------PLIDLRLLRR-----RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLpGALVM 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 260 MLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVT-TNIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNNQGFFLS 337
Cdd:cd17504 231 LIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNIVVESVpPDRTGIATG 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 338 VNTFVLFLGTAIAPILMLFV-------------GELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17504 311 MNTVLRTIGSAIGPAIAGAIlttytvsitsggvPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-383 |
4.96e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 93.43 E-value: 4.96e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGI 93
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 94 VHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILY 173
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 174 LILVLVIYkNVPESPHKNPDIQLIKffnnfKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMK 253
Cdd:cd17489 161 LLALLLVF-LVKDPPPVAAEEAEAG-----TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 254 LFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISK-IGVVVKNNQ 332
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALaVDLVPPHRR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488368504 333 GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIF 383
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-354 |
1.13e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 92.24 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 22 MASLYTALPltaTFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLL 101
Cdd:cd17321 12 VTIVNVALP---TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 102 ILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLviy 181
Cdd:cd17321 89 AARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 182 knvpesphknpdiqLIKFFnnfkdfkdnlkvfycLFISLTLLIMFISMYDILNEYVTSHQVGGDMS---VSSMMKLFGVI 258
Cdd:cd17321 166 --------------LARTF---------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSplqAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 259 GMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILM-GVTTNIILITTFSVLFVAGIAFAI---PTVISKIGVVVKNNQGF 334
Cdd:cd17321 217 MLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLaLLGADSSVWLLLPGLVLLGLGLGLfatPLTNAALSSVPKEKAGA 296
|
330 340
....*....|....*....|
gi 488368504 335 FLSVNTFVLFLGTAIAPILM 354
Cdd:cd17321 297 ASGILNTARQLGGALGVALL 316
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-384 |
1.03e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.83 E-value: 1.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 3 ESKNYNLITTIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMS 82
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 83 ALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRvKRVTAISFISTSFMLSGVLGQNMSELVVSY--- 159
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 160 LNWQWVYFILTILYLILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMfISMYDILNEYVTS 239
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAE-GAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 240 HQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPT 319
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488368504 320 VISKIGVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-385 |
1.27e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 86.47 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 12 TIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMI 91
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 92 GIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSyLNWQWVYFILTI 171
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 172 LYLILVLVIYKnVPESPHKnpDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSM 251
Cdd:cd17473 162 ALPVLILVLLF-LPEPARK--SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 252 MKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKI-GVVVKN 330
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAmSLVPPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 331 NQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQ-FLMIAIVGLIALVVSIFMP 385
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGaFLILGVLALVLAIVLLLLR 374
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-384 |
5.56e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.16 E-value: 5.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 33 ATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAA 112
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 113 SFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPesphknp 192
Cdd:cd17319 107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 193 diQLIKFfnnfkdfkdnLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGgdmSVSSMMKLFGVIGMLLSllaGRVSSR 272
Cdd:cd17319 180 --QVWGL----------ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVG---LLAAIPFLAGAIGMILG---GRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 273 IGIK--RLLTIALTTC-IVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQ-GFFLSVNTFVLFLGTA 348
Cdd:cd17319 242 LLRGarRLVIIIGLLLaAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAaATAGGLINSGGNLGGF 321
|
330 340 350
....*....|....*....|....*....|....*..
gi 488368504 349 IAPILM-LFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17319 322 VAPLLIgYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-383 |
1.75e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 83.24 E-value: 1.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGV 109
Cdd:cd06174 17 PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYL--NWQWVYFILTILYLILVLVIYKNVPES 187
Cdd:cd06174 97 GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 188 PH----KNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLS 263
Cdd:cd06174 177 PEsaraKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 264 LLAGRVSSR-IGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNNQGFFLSVNTF 341
Cdd:cd06174 257 LLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 488368504 342 VLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIF 383
Cdd:cd06174 337 FGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-187 |
1.82e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.00 E-value: 1.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 9 LITTIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFI 168
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|....*....
gi 488368504 169 LTILYLILVLVIYKnVPES 187
Cdd:COG0477 174 NAPLGLLALVLRLR-LPES 191
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-384 |
5.29e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 75.73 E-value: 5.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 13 IMFISGIIVMASLYTALPLTAT-FAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMI 91
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 92 GIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYlNWQWVYFILTI 171
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 172 LYLILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSM 251
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 252 MKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAF---AIPTVISKIgvVV 328
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLvfpAVQTLVAAL--AP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 329 KNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-384 |
2.14e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 73.80 E-value: 2.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 48 LNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVH-----SFTVLLILRALQGVFAASFSPVVMTYT 122
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 123 TETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYL---ILVLVIYKNVPESPHKNPDIQLIKF 199
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLlsaLLLLFIRRPPPAAPGESSSLLLRDL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 200 FNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLL 279
Cdd:cd06173 198 REGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 280 TIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNN-QGFFLSVNTFVLFLGTAIAPILMLFVG 358
Cdd:cd06173 278 LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
330 340
....*....|....*....|....*.
gi 488368504 359 ELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd06173 358 DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
10-181 |
6.80e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 72.22 E-value: 6.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 10 ITTIMFISGIIVMASlYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICL 89
Cdd:cd17323 1 VFIISFLTFVVTFGS-SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 90 MIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFIL 169
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170
....*....|..
gi 488368504 170 TILYLILVLVIY 181
Cdd:cd17323 160 AIISGFCLILIF 171
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
29-315 |
7.62e-14 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 72.42 E-value: 7.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:TIGR00710 25 LPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 109 VFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESP 188
Cdd:TIGR00710 105 FGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 189 HKNPDIQLIKFFNNFKD-FKDNLKVFYCLFISLTLLIMFIsmYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLL-SLLA 266
Cdd:TIGR00710 185 PYEARIQISTYFETFLLlLKSKMFWGYALIYGASFGGFFA--FFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFgGFLN 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 488368504 267 GRVSSRIGIKRLLTIALTTCIVSIILMGVTtniILITTFSVLFVAGIAF 315
Cdd:TIGR00710 263 GRFIKKWGAKSLLRMGLILFAVSAVLLEIT---AILGLGSWAMIIGPMM 308
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
27-385 |
1.77e-13 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 70.67 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 27 TALPltaTFAEDFHVPESIATLnGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRAL 106
Cdd:cd17502 17 TALP---TIVAEFGGLSLVSWV-GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 107 QGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFIltilylilvlviykNVPe 186
Cdd:cd17502 93 QGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI--------------NLP- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 187 sphknpdIQLIKFFNnfkdfkdnlkVFYCLFISLTLLIMFISMYDILNEYVTSHQ-VGGDMSVSSMMKLFGVIGMLL--S 263
Cdd:cd17502 158 -------IGGLALAL----------LRTILLSSIFGFLFGGALFGLIYYLPLYFQlVLGDSATKSGVRLLPLIIGLVigS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 264 LLAGRVSSRIG-IKRLLTIALTTCIVSIILM---GVTTNIILITTFSVLFVAGIAFAIP-TVISKIGVVVKNNQGFFLSV 338
Cdd:cd17502 221 IISGALISKTGrYKPLIVIGTILMSVGAGLLttlTLDTSKWLLIGYLILLGLGLGIGFQqPLVAVQNAVPPADVGVATAT 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 488368504 339 NTFVLFLGTAIApilmlfvgelSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17502 301 NTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSLFLP 337
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-383 |
4.20e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 69.91 E-value: 4.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:cd17330 19 LPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 109 VFAASFSpVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPesp 188
Cdd:cd17330 99 LTGGNVS-VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 189 hknpdiqlikffnnfkdfkdnlKVFYCLFISLTLLIMFISMYDILneYVTSHQVGGDMS--VSSMMKLFGVIGMLLSLL- 265
Cdd:cd17330 175 ----------------------PLRRLLLVYFLIALAFAGLESVF--SLFLKDRFGFSPsqIGLLLALVGIAGILAQLLl 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 266 AGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNNQGFFLSVNTFVLF 344
Cdd:cd17330 231 IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVpSKEQGKAQGIIQSLQS 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 488368504 345 LGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIF 383
Cdd:cd17330 311 LARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-385 |
4.28e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 70.02 E-value: 4.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 50 GVLFSLT---YSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETY 126
Cdd:cd17371 37 GLLGTVTlagGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 127 PRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLN----WQWVyFILTILYLILVLVIYKNVPESP------HKNPDIQL 196
Cdd:cd17371 117 PARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVL-FLLGALPALLVLFIRRFVKEPPqwqaarAARRHFAD 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 197 IKFFNNFKDfKDNLKVFycLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSM---MKLFGVIGMLLSLLAGRVSSRI 273
Cdd:cd17371 196 RPSLRELFS-PPLLRTT--LLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSagyLVVTILGGFLGYLAGGFLADRI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 274 GIKRLLTIALTTCIVSIILM---GVTTNIILITTFSVLFVAGIAF---------AIPTVISKIGVVVKNNQGfflsvntf 341
Cdd:cd17371 273 GRRNNFALFALGSAISILLYfflPLSPTLILILGFPLGFFASGPFsgmgaylteLFPTAVRATAQGFCYNVG-------- 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488368504 342 vlFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17371 345 --RIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
131-384 |
4.75e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 4.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 131 RVTAISFISTSFMLSGVLGQNMSELVVSYL------NWQWVYFILTILYLILVLVIYKNVPESPHknPDIQLIKFFNNFK 204
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPV--PEEEKVSLKESLK 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 205 DFKDNlKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLS-LLAGRVSSRIGIKRLLTIAL 283
Cdd:COG2211 223 ALLKN-RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGaPLWPRLAKRFGKKKAFIIGL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 284 TTCIVSIILMGV--TTNIILITTFSVLFVAGIAFAIPTVISKIGVVV--------KNNQGFFLSVNTFVLFLGTAIAPIL 353
Cdd:COG2211 302 LLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGAL 381
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 488368504 354 MLFVGELSNF-----------FLQFLMIAIVGLIALVVSIFM 384
Cdd:COG2211 382 AGLLLALFGYvagaaqspsalTGIRLLFFLLPAVLLLLAALL 423
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
16-385 |
5.23e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 69.55 E-value: 5.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 16 ISGIIV--MASLYTALPLTATFAEDFhvPESIATLNGV---LFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLM 90
Cdd:cd17472 1 LSLIFSlrMLGMFLVLPVLSVYAKSL--PGATPTLIGLalgIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 91 IGIVHSFTVLLILRALQGvfAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILT 170
Cdd:cd17472 79 AAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 171 ILYLILVLVIYKNVPESPhKNPDIQLiKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGgdmsVSS 250
Cdd:cd17472 157 ILSLVSLLILLFFVPDPP-KIVQISE-KEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGG----KGQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 251 MMKLFG---VIGMLLSLLAGRVSSRIGI-KRLLTIALTTCIVSIILMGVT-TNIILITTFSVLFVAGIAFAIPTVISKIG 325
Cdd:cd17472 231 LWKVYLpaiLIGFILMVPFVIYAEKKGKmKQVFVSSILLIAVGFLLLLFAaTSLWLLIIGLIIFFIGFNLLEALLPSLVS 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 326 VVVKNNQ-GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17472 311 KIAPKEYrGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
27-385 |
8.78e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.14 E-value: 8.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 27 TALPltaTFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRAL 106
Cdd:cd17503 17 VALP---TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 107 QGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYknvpe 186
Cdd:cd17503 94 QGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAP----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 187 sphknpdiqlikfFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSvSSMMKLFGVIGMLLSLLA 266
Cdd:cd17503 169 -------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFES-GLVLAPGGLASAILSPLV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 267 GRVSSRIGIKRLLTIALTTCIVSIILMG---VTTNIILITTFSVLFVAGIAFAI-PTVISKIGVVVKNNQGFFLSVNTFV 342
Cdd:cd17503 235 GRLLDKFGPRLLLLAGLLLLALGTLLLAfltPDTSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPPEQIGDATALFNTI 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 343 LFLGTAIA-PILMLFVGELSNFFL----------------------QFLMIAIVGLIALVVSIFMP 385
Cdd:cd17503 315 RQLGGSIGtALLATLLTNRTQFHHsrlsellaqqvqkqaliiafndAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-378 |
1.71e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.97 E-value: 1.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 15 FISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIV 94
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 95 HSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQnMSELVVSYLNWQ--WVYFILTIL 172
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP-LLLALVGTAGALpfLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 173 YLILVLVIYKNVPESPhKNPDIQLIKFFNNFKdfkdnLKVFYCLFISLTLlimfISMYDILNEYVTSHQVGGDmSVSSMM 252
Cdd:cd17477 161 ALVPLLLTRRAAPEIE-EAESISLRRLLRIAP-----LALLGAFVAGFLE----GAFYSLLPLYGLRLGLSVA-QAALLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 253 KLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAI-PTVISKIGVVVKNN 331
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 488368504 332 Q-----GFFLSVNTFVLFLGTAIAPILMLFVGElSNFFLQFLMIAIVGLIAL 378
Cdd:cd17477 310 ElvaanAALLLLYGLGSVIGPLLAGALMDAFGP-HGLFLFLAAVALLFLLFL 360
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-187 |
2.90e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 67.62 E-value: 2.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 1 MEESKNYNLITTIMFISGIIVMA-SLYtaLPLTATFAEDFHVPESiaTLNGVL--FSLTYSISCLFYGTISEKYGRIKTI 77
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAqTIY--VPAIADMARDLNVREG--AVQAVMaaYLLTYGLSQLFYGPLSDRVGRRPVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 78 LVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVV 157
Cdd:PRK11652 77 LVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLT 156
|
170 180 190
....*....|....*....|....*....|
gi 488368504 158 SYLNWQWVYFILTILYLILVLVIYKNVPES 187
Cdd:PRK11652 157 TLFGWRACYLFLLLLGAGVTFSMARWMPET 186
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-384 |
4.19e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.21 E-value: 4.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 9 LITTIMFIsGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:COG2807 19 LLLAIVLV-ALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRvKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYF- 167
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAv 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 168 --ILTILYLILVLVIYKNVPESPHKNPDIQLIKFFnnfkdFKDNLKVFYCLFISLTLLImFISMYDILNEYVTSHQVGGD 245
Cdd:COG2807 177 waLLALLALLLWLPLLRRRPAAAAAAPAAASLRSL-----WRSPLAWLLTLFFGLQSLL-YYAVVAWLPPILRDAGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 246 MSvSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIG 325
Cdd:COG2807 251 TA-GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIG 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 326 VVVKNNQ------GFFLSVNtfvlFLGTAIAPILMLFVGELS-NFFLQFLMIAIVGLIALVVSIFM 384
Cdd:COG2807 330 LRARTPAeaaalsGMAQSVG----YLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-379 |
4.69e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 4.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 9 LITTIMFISGIIVMASLYTALPLTATFaeDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSF----MLSGVLGQNMSELVVSYLNWQW 164
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWalgaLLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 165 VYFILTILYLILVLVIYknvpesphknpdiqlikffnnfkdfkdnlKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGG 244
Cdd:cd17316 161 LFLIGALPALLALLLRR-----------------------------RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 245 DMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMG--VTTNIILITTFSVL---FVAGIAFAIPT 319
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFylLSGSPTLLLLLLFIlsfFVGGVWGALYA 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 320 VISKI--------GVvvknnqGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALV 379
Cdd:cd17316 292 YLAELfptevratGV------GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
73-379 |
2.83e-11 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 2.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 73 RIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKR---VTAISFISTSFMLSGVLG 149
Cdd:cd17471 62 RKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGrdaTLFNSVLRAAFSLAWVIG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 150 QNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESPhknPDIQLIKFFNNFKDFKDNLKVFYcLFISLTLLIMFISM 229
Cdd:cd17471 142 PPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVK---PPAQKATPASSLVKAPVNRRLLL-LFAAFTLLFAANSM 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 230 YDI-LNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVL 308
Cdd:cd17471 218 YIIaMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL 297
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 309 FVAGIAfaiptVISKIGVV-----VKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALV 379
Cdd:cd17471 298 NAIFIG-----ITAGLGISyfqdlMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
14-384 |
1.04e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 62.67 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALPLTATFAEDFHV--PESIATLNGVLFSLTYSISCLF---YGTISEKYGRIKTILVGMSALVIIC 88
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVtsGGLVELWSGLAFSSTFLVSAIFspiWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAAsFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFI 168
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 169 LTILYLI-----LVLVIYKNVPESPHKnpDIQLIKFFNNFKdfkdNLKVFYCLFIsLTLLIMFI--SMYDILNEYVT--S 239
Cdd:cd17391 160 TGGLLFLaflltLFFVKEDFKPVEKKK--MVSTKEVWNSVP----NPSLLISLFV-TTFIIQLAnqSIEPILTLYIRqlM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 240 HQVGGDMSVSSM-MKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLF---VAGIAF 315
Cdd:cd17391 233 GDASNLAFISGLvFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLglaTGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 316 AIPTVISKIgvVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17391 313 AINSLLAKI--TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-318 |
1.02e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.68 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 13 IMFISGIIVMASLYTALPLTATFAEDFHVPESI--ATLNGVLFSltysisCLFYGTISEKYGRIKTILVGMSALVIICLM 90
Cdd:TIGR00895 25 IMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLfsAGLIGMAFG------ALFFGPLADRIGRRRVLLWSILLFSVFTLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 91 IGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILT 170
Cdd:TIGR00895 99 CALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 171 ILYLILVLVIYKNVPES----------------------PHKNPDIQL---IKFFNNFKDFKDNLKVFYCLFISLTL--- 222
Cdd:TIGR00895 179 IAPLLLLLLLMRFLPESidflvskrpetvrrivnaiapqMQAEAQSALpeqKSTQGTKRSVFKALFQGKTARITVLLwll 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 223 LIMFISMYDILNEY--VTSHQVGGDMSVSS-MMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNI 299
Cdd:TIGR00895 259 YFMLLVGVYFLTNWlpKLMVELGFSLSLAAtGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSP 338
|
330
....*....|....*....
gi 488368504 300 ILITTFsvLFVAGIAFAIP 318
Cdd:TIGR00895 339 TLLLLL--GAIAGFFVNGG 355
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
12-188 |
2.16e-09 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 59.22 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 12 TIMFISGIIVMA---SLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIIC 88
Cdd:TIGR01299 167 ALFFVLGLALMAdgvEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFA 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 89 LMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQW---- 164
Cdd:TIGR01299 247 FFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFqmgs 326
|
170 180 190
....*....|....*....|....*....|..
gi 488368504 165 --------VYFILTILYLILVLVIYKNVPESP 188
Cdd:TIGR01299 327 ayqfhswrVFVIVCAFPCVFAIGALTFMPESP 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-384 |
2.71e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 210 LKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVS 289
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 290 IILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV-KNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFL 368
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170
....*....|....*.
gi 488368504 369 MIAIVGLIALVVSIFM 384
Cdd:COG2814 169 VNAVLALLALLLLLRL 184
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-383 |
3.77e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.72 E-value: 3.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGV 109
Cdd:cd17333 17 ILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPVVMTYTTETYPRvKRVTAISFISTSFMLSGVLGQ-NMSELVVSYLNWQWVYFILTILYLILVLVIYK-NVPES 187
Cdd:cd17333 97 GAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPlIATSLLTSELSWSWAYLIIGLIYLLLAILILLtLFPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 188 PHKNPDIQLIKFFNnfKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKL---FGVIGMLLSL 264
Cdd:cd17333 176 PSARNPQQSVGAFS--ASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLlsgFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 265 LAGRVSSRIGIKRLL----TIALTTCIVSIILMGVTTNIILiTTFSVLFVAGIAFAIPTV-ISKIGVVVKNNQGFFLSVN 339
Cdd:cd17333 254 LGGPISRRIKPHTLLvlsgSGALLGLLILLLAPTLVVGLVA-TALLGLFMAALFPTILSLgISNLPYAKGKGTSVLLAAG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488368504 340 TFvlflGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIF 383
Cdd:cd17333 333 SI----GGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
37-188 |
5.23e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.63 E-value: 5.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 37 EDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSP 116
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSP 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 117 VVMTYTTETYPRVKRVTAISFISTSF----MLSGVLGQNMSELVvsyLNWQWVYFILTILYLILVLVIYKNVPESP 188
Cdd:cd17328 107 IAPTIIADLFPKEKRTRALGVFYFAIplgsGLGYVVGGLVAQAT---GGWRWAFRVTGVLGVLLAILLLLFVREPP 179
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-314 |
7.04e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 56.88 E-value: 7.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 15 FISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGI- 93
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALa 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 94 VHSFTVLLILRALQGVFAASFSpVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVV-------SYLNWQ--- 163
Cdd:cd17341 85 VSSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdgGFVGWRnaf 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 164 WVYFILTILYLILVLVIYKNVPESPHKNPdiqlikffNNFKDFKDNLKVFYCLFISLTLLIMF---ISMYDILNEYVTSH 240
Cdd:cd17341 164 FVPGILLAIAAVLVLLFGDDLPTGKASAL--------EFLKVQLAVLKNYRTWILSLLYGVTFgsfVGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488368504 241 QVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLT---IALTTCIVSIILMGVTTNIILITTFSVLFVAGIA 314
Cdd:cd17341 236 FGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWwlfIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
50-314 |
9.01e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 9.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 50 GVLFSLTY---SISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETY 126
Cdd:cd17365 37 GPVGSAALfgmAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 127 PRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLviyknvpesphknpdiqlikffnnfkdf 206
Cdd:cd17365 117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP---------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 207 kdnlkvfyCLFISLTLLIMF----ISMYdILNEYVTSHQVGGDMSVSS---MMKLFGVIGMLLSLLAGRVSSRIGIKRLL 279
Cdd:cd17365 169 --------LLRGTLLLWVTFfmglLLVY-LLNSWLPKLMVEAGYSLSQaltITLLLNIGGVIGSLLLGWLADRFGPKRVL 239
|
250 260 270
....*....|....*....|....*....|....*
gi 488368504 280 TIALTTCIVSIILMGVTTNiILITTFSVLFVAGIA 314
Cdd:cd17365 240 ALFFALGAVSLALLGVSPA-SLVLLYVLVFLAGAC 273
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-204 |
1.41e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 56.05 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:PRK11043 26 LPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 109 VFAASFSPVVMTYTTETYP--RVKRVTAisfistSFM----LSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYK 182
Cdd:PRK11043 106 VGVCSAAVIWQALVIDRYPaqKANRVFA------TIMplvaLSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLR 179
|
170 180
....*....|....*....|..
gi 488368504 183 NVPESPHKNPDIQLIKFFNNFK 204
Cdd:PRK11043 180 LKPSKKARKQSQDALTFKQLLK 201
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-188 |
1.54e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 56.18 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 59 ISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFI 138
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLI 221
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488368504 139 STSFMlsgvLGQnMSELVVSYLN--WQWVYFILTiLYLILVLVIYKNVPESP 188
Cdd:TIGR00898 222 QVFFS----LGL-VLLPLVAYFIpdWRWLQLAVS-LPTFLFFLLSWFVPESP 267
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
15-380 |
1.72e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 15 FISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIV 94
Cdd:cd17355 9 FLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 95 HSFTVLLILRALQGVFAASFSPVVM--TYTTETYPRvKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTIL 172
Cdd:cd17355 89 TSLWQLYLLWGLLGGGGAGTLAAVAfaTVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 173 YLILVLVIY--KNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVT--SHQVGGDMSV 248
Cdd:cd17355 168 ALLVLVPVLllLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPylADRGISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 249 SSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAipTVISKIGVVV 328
Cdd:cd17355 248 AVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGA--TVPLTAALAA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488368504 329 KN----NQGFFLSVNTFVLFLGTAIAPILM-LFVGELSNFFLQFLMIAIVGLIALVV 380
Cdd:cd17355 326 RYfgarSYGTLFGLVFAPHQLGSALGPWLGgLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
52-363 |
1.79e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.84 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 52 LFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKR 131
Cdd:TIGR00881 38 SFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 132 VTAISFISTSFMLSGVLGQNMSELVVSYLN-WQWVYF---ILTILYLILVLVIYKNVPES---------PHKNPDIQLIK 198
Cdd:TIGR00881 118 GTWVSFWNCSHNVGGGLLPPLVLFGIAELYsWHWVFIvpgIIAIIVSLICFLLLRDSPQScglppaeemPNEEPDGDAEK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 199 FFNNFKDFK-------DNLKVFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSS 271
Cdd:TIGR00881 198 KEEELTKKQiflqyvlLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSD 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 272 RI-GIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVV-----KNNQGFFLSVNTFVLFL 345
Cdd:TIGR00881 278 KLfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIAselapKKAAGTAAGFVGFFAYL 357
|
330
....*....|....*...
gi 488368504 346 GTAIAPILMLFVGELSNF 363
Cdd:TIGR00881 358 GGILAGLPLGYLADGFGW 375
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-181 |
2.08e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 55.28 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 45 IATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTE 124
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 125 TYPRVKRvtaiSFISTSFMLSGVLGQNMSELVVSYL-NWQWVYFILTILYLILVLVIY 181
Cdd:cd17317 106 IVGPKYR----SFVGILFGLFWALGYMLLALLAYLIrDWRWLQLAISLPGLLFLLLLW 159
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
19-185 |
4.31e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 54.58 E-value: 4.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 19 IIVMASLYTALPLTA------TFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIG 92
Cdd:cd17476 2 TISGAQLLNQAGLGSvivilpIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 93 IVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVT-AISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTI 171
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAI 161
|
170
....*....|....*
gi 488368504 172 L-YLILVLVIYKNVP 185
Cdd:cd17476 162 LaAIVAVAAIFWTSP 176
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
29-187 |
7.58e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 53.77 E-value: 7.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:PRK11102 11 LPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 109 VFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPES 187
Cdd:PRK11102 91 LAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-382 |
7.65e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.71 E-value: 7.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGV 109
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPVVMTYTTETYPRvKRVTAISFistsFMLSGVLGQNMSELVVSYLNWQW---VYFILTILYLILVLVIYKnvpe 186
Cdd:cd17478 97 GSAAFHPEGARLASQAAGG-RRGLAMSI----FSVGGNLGFALGPLIAAALVALFgglGLLILLIIPGLAVALLLL---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 187 sPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDI-LNEYVT--SHQVGGDMSVSSMM-KLFGVIGMLL 262
Cdd:cd17478 168 -RLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSsLTTFLPfyLVQRGYSLVFAGLLlSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 263 SLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILItTFSVLFVAGIAFAIPTVISKIGVVVKNNQGFFLSVNTFV 342
Cdd:cd17478 247 TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGL 325
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 488368504 343 LFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSI 382
Cdd:cd17478 326 SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
6-381 |
1.36e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 53.00 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 6 NYNLITTIMFISGIIVMASLYTALPLTATFAEDFHVP--ESIATLNGVLFSLTY---SISCLFYGTISEKYGRIKTILVG 80
Cdd:PRK09874 11 NWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTghSALNMWSGLVFSITFlfsAIASPFWGGLADRKGRKIMLLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 81 MSALVIICLMIGIVHSFTVLLILRALQGVFAAsFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYL 160
Cdd:PRK09874 91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSY 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 161 NWQWVYFILTILYLILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVtsH 240
Cdd:PRK09874 170 GLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYV--R 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 241 QVGGDMS----VSSMM-KLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAF 315
Cdd:PRK09874 248 ELAGNVSniafISGMIaSVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGA 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 316 AIPTVISKIgVVVKNNQ--GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVS 381
Cdd:PRK09874 328 LLPAVQTLL-VYNSSNQiaGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYS 394
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
254-385 |
6.24e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.58 E-value: 6.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 254 LFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQ- 332
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPAREr 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488368504 333 GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:COG0477 137 GRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
254-390 |
6.36e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 6.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 254 LFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQ- 332
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEEr 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 333 GFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMPGDQRS 390
Cdd:cd17325 119 GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP 176
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
251-388 |
1.08e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 251 MMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILIttFSVLFVAGIAFAIPTVISKI---GVV 327
Cdd:cd17477 36 VASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW--FLLRFVMGIGLAGLFVVSESwlnALA 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 328 VKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFlqFLMIAIVGLIALVVSIFMPGDQ 388
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALP--FLIAAVLLLLALVPLLLTRRAA 172
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
31-189 |
1.54e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 49.88 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 31 LTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVF 110
Cdd:cd17358 28 LMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFG 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 111 AASFSPVVMTYTTETYPRVKRVTAISFistsFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKnVPESPH 189
Cdd:cd17358 108 GGAASVVVPVYIAEIAPKNVRGALGSL----NQLLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFF-IPESPR 181
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
161-383 |
1.72e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.55 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 161 NWQWVYFILTILYLILVLVIYKNVPE--------------SPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMF 226
Cdd:cd17313 177 NLKVPFYIGAIILLVCVLVTLFFVKEpplspeagehsenpSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELF 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 227 ISMYDILNEYVTS--HQVGGDMSVSS---MMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIIL 301
Cdd:cd17313 257 FTDYMGEEVYHGTsaASSHYGAGVRMgawGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 302 itTFSVLFVAGIAFAIP-----TVISKIGVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLI 376
Cdd:cd17313 337 --ALVLFALGGIGWATIninpyPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFL 414
|
....*..
gi 488368504 377 ALVVSIF 383
Cdd:cd17313 415 SLVGALF 421
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
38-188 |
2.38e-06 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 49.53 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 38 DFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPV 117
Cdd:cd17440 28 DMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 118 VMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQW------------VYFILTILYLILVLVIYKNVP 185
Cdd:cd17440 108 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFsmgsayqfhswrVFVIVCALPCVSSVVALTFMP 187
|
...
gi 488368504 186 ESP 188
Cdd:cd17440 188 ESP 190
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
62-187 |
2.74e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 49.31 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTS 141
Cdd:PRK03893 73 LLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISG 152
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488368504 142 FMLSGVLGQNMSELVVSYLNWQWVYFIlTILYLILVLVIYKNVPES 187
Cdd:PRK03893 153 FSIGAVVAAQVYSLVVPVWGWRALFFI-GILPIIFALWLRKNLPEA 197
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
62-385 |
5.05e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 48.06 E-value: 5.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFT--------VLLILRALQGVFAASFSPVVMTYTTETYPRVKRVT 133
Cdd:cd17367 58 WLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 134 AISFISTSFMLSGVLGQNMSELVVSYLN------WQW-VYFILTILYLILVLVIYKNVPESPH-KNPDIQLIKFFNNFKD 205
Cdd:cd17367 138 YSSFQYVTLIGGQLLALGVLLVLQHTLGedqmaaWGWrIPFLLGGVLAVVVLWLRRGLEETESfEAIAESNEASAGTLRE 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 206 FKDNLK-VFYCLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLL---TI 281
Cdd:cd17367 218 LRRHPReLLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLlffGI 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 282 ALTTCIVSIIL-------MGVTTNIILITTFSVLFVAGIAFAI-----PTVISKIGVVVknnqGFFLSVntfVLFLGTAI 349
Cdd:cd17367 298 GGTLATVPLLSaldhtdsPYTAFALVLVGLVFLSGYTSINAVVkaelfPTHVRALGVGL----PYALAV---AIFGGTAP 370
|
330 340 350
....*....|....*....|....*....|....*.
gi 488368504 350 APILMLFVGELSNFFlqFLMIAIVGLIALVVSIFMP 385
Cdd:cd17367 371 YVALWLKSIGHEWVF--FWYVAGLIAISLVVYLRMP 404
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
216-383 |
5.73e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 5.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 216 LFISLTLLIMFISMYDILNEYVTSHQVGGDMS-VSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMG 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTeIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 295 VTTNIILITTFSVLFVAGIAFAIPTVISKIG-VVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIV 373
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIAdWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|
gi 488368504 374 GLIALVVSIF 383
Cdd:pfam07690 161 SLLAAVLLLL 170
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
13-384 |
6.28e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 6.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 13 IMFISGIIVMASL---YTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICL 89
Cdd:cd17353 4 LVLLGAVLMHLILgyqYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 90 MIGIVHSFTVLLILRALQG------VFAASFSPVVMTYTTetyprvKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQ 163
Cdd:cd17353 84 LSAFAISLPLLFLGYGVLGgigagiGYITPVSTAVKWFPD------KRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 164 WVYFILTILYLILVLV---IYKNVPES---PHKNPDIQLIKFFNNFKDFKDNLK--VFYCLFISLTLLIMFISM-YDILN 234
Cdd:cd17353 158 TTFLILGIIFLIIIVIgafLIRDPPKGwvpPGVDPLANNAENSPRDYTPREMLRtpTFWLLWLMFFLNATAGLMlIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 235 EYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTtcIVSIILMGVTTNIILITTFsVLFVAGIA 314
Cdd:cd17353 238 PIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL--IQGVAMFLLPFIGSVAVLF-VLGVALIG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 315 FAIPTVISKIGVVVKNNQGF-FLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17353 315 FCYGGGFALFPALTADFFGTkNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
86-191 |
1.03e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 47.24 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 86 IICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLN---- 161
Cdd:cd17327 83 LLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGvggl 162
|
90 100 110
....*....|....*....|....*....|..
gi 488368504 162 --WQWVYFILTILYLILVLVIYKNVPESPHKN 191
Cdd:cd17327 163 agWRWLFIIEGLITIIIGLVIFFWLPDNPSKA 194
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
14-149 |
1.12e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGI 93
Cdd:cd17370 204 LYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 94 VHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLG 149
Cdd:cd17370 284 GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLA 339
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
216-385 |
1.39e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.65 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 216 LFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGV 295
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 296 TTNIILITTFSVLFVAGIAFAIPTVISKIG-VVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGE--LSNFFLQFLMIAI 372
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIAdLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170
....*....|...
gi 488368504 373 VGLIALVVSIFMP 385
Cdd:cd06174 161 LALLAAILLLLVV 173
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
248-385 |
1.94e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 248 VSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVV 327
Cdd:cd17474 36 VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 328 VK-NNQGFFLSVNTFVLFLGTAIAPILMLFVGELSnFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17474 116 FEgGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-WRYPFFLLAALIPVAFLAILFLL 173
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
14-184 |
2.00e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.10 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALPLTATFAEDFHVPES-IATLNGVLFS---LTYSISCLFYGTISEKYGRIKTILVGMSALVIICL 89
Cdd:cd17391 206 LFVTTFIIQLANQSIEPILTLYIRQLMGDASnLAFISGLVFSatgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYI 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 90 MIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFIL 169
Cdd:cd17391 286 PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVT 365
|
170
....*....|....*
gi 488368504 170 TILYLILVLVIYKNV 184
Cdd:cd17391 366 ALLVLLNAIWSFIFL 380
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
45-383 |
2.00e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.84 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 45 IATLNGVLFSLTYSISCLFYGTISEKYGR------IKTILVGMSALVIICLMIGivhSFTVLLILRALQGVFAASFSPVV 118
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKnrviriVKLFEVGLTLLIVLAYYLG---WFWLAFAVTFLLGAQSAIYSPAK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 119 MTYTTETYPRVKRVTAISFI-STSFM---LSGVLGQNMSELVVSYLNWQWVYFILTILYLILV-----LVIYKNVPESPH 189
Cdd:PRK08633 125 YGIIPELVGKENLSRANGLLeAFTIVailAGTALFSFLFESVNGNTPSEILGRIAPAGLVLLAvavlgLIFAYRLPKVPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 190 KNPDIQLIKFFNNFKDFKDNLK-VFYCLFISLTLL----IMFISMYDILNEYVTSHQVGG--DMSVSSMMKLFGVIGMLL 262
Cdd:PRK08633 205 AAPEVFDKKKYLFPKLLWRNLKlLRSDRVLWLAIIglsyFWFISQLAQANFPAYAKEVLGldNTFQVQYLLAASAIGIGI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 263 -SLLAGRVSSR---IGIKRLLTIALTTCIVsiiLMGVTTNIILITTFSVLF-VAGIAFAIPtVISKIGVVVKNNQ-GFFL 336
Cdd:PRK08633 285 gSLLAGRLSGRhieLGLVPLGALGLALSLF---LLPTAPSLASVLVLFFLFgFSAGLFIVP-LNALIQFRAPEKElGKVL 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488368504 337 SVNTFVLFLGTAIAPIL--MLFVGELSNFFLqFLMIAIVGLIALVVSIF 383
Cdd:PRK08633 361 AANNFLQNVGMLLFLALttLFSGLGLSPAGL-FYLIALVTLIGTLYTLL 408
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
58-380 |
2.64e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 58 SISCLFYGTISEKYGRIKTILV-GMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAIS 136
Cdd:cd17370 48 SLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 137 FISTSFMLSGVLGQNMSELVVSYLNW--QWVYFILTILYLILVLVIYKNVPESPHKnPDIQLIKFFNNFKDFKDNLKvfy 214
Cdd:cd17370 128 LHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALLALLILLFVVKEYPRP-PKLRKKSKKTSLKKLPKAFW--- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 215 cLFISLTLLIMFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMG 294
Cdd:cd17370 204 -LYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 295 VTTNIILITTFSVLFvaGIAFAI-----PTVISKIgvVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLM 369
Cdd:cd17370 283 LGSSLWLLLLGFILW--GLYMGAqesieRAAVADL--VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
330
....*....|.
gi 488368504 370 IAIVGLIALVV 380
Cdd:cd17370 359 SAVLALIALLL 369
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
62-317 |
3.92e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 3.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKT-----ILVGMSALVIICL----MIGIVhSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRV 132
Cdd:cd17369 62 VVFGHFGDRIGRKKTlvltlLLMGIATFLIGLLptyaQIGIL-APILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 133 TAISFISTSFMLsGVLGQNMSELVVS-------YLNWQW-VYFILTILYLILVLVIYKNVPESPHknpdiqlikffnnFK 204
Cdd:cd17369 141 FYGSFPQLGAPV-GLLLATGVFLLLSallsdeaFLSWGWrIPFLLSAVLVAVGLYIRLRLEETPV-------------FR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 205 DFKDNLKVFYC------------LFISLTLLIMFISMYDILNEYVTS---HQVGGDMSVSSMMKLFGVIGMLLSL-LAGR 268
Cdd:cd17369 207 RAKEAGQVVRAplvevlrrhwraLLLAIGLRLAENVLFYLFTTFALSyatQTLGVDRSTVLLAVLIASVVAAITIpLFGW 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 488368504 269 VSSRIGIKRLLTIALTTCIVSI--ILMGVTTNIILITTFSVLFVAGIAFAI 317
Cdd:cd17369 287 LSDRVGRRPVYLAGALLAALFAfpFFWLLDTGSTWLIVLAAVVVLGVLHGM 337
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
31-311 |
4.16e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.99 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 31 LTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIV-HSFTVLLILRALQGV 109
Cdd:TIGR00886 24 AVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 110 FAASFSPvVMTYTTETYPRVKRVTAISF----------ISTSFMLSGVLGQNMSELVVSYLNWQWVYFILT-ILYLILVL 178
Cdd:TIGR00886 104 AGGSFAS-CMPWISFFFPKKIQGTALGLaagwgnmgggVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPaGILLLPAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 179 VIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLImFISMYDILNEYVTSHQVGGDMSVSSMMKLFGVI 258
Cdd:TIGR00886 183 LIFFVGADTPPGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGS-FLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFL 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 488368504 259 GMLLSLLAGRVSSRIG-IKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVA 311
Cdd:TIGR00886 262 GSLARPAGGAISDRLGgARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVA 315
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
243-385 |
4.53e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 243 GGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILIttFSVLFVAGIAFAIPTVIS 322
Cdd:cd17489 28 GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL--LVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 323 K---IGVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17489 106 AtlvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVK 171
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
22-380 |
4.59e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.27 E-value: 4.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 22 MASLYTALPLTATFAEDFHV-PESIATLNGvLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVII--CLMIGIVHSFT 98
Cdd:cd17335 10 FAALGSLLPFLSVYLKQLGLsPTQIGILIG-IRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLffLSLFFVAQIFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 99 VLLILRALQGVFAASFSPVVMTYT-------TETYPRVKRVTAISFISTSFmLSGVLGQNMSelvvSYLNWQWVYFILTI 171
Cdd:cd17335 89 LLLLLVILGAFFSAPVVPLVDSITlqylgeeRERYGKQRLWGSIGFGIAAL-LVGILIDRSS----TYKNYTIAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 172 LYLILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILneyvtsHQVGGDMSVSSM 251
Cdd:cd17335 164 LMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHL------QDLGGSKTLIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 252 MKLFGVI-GMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTN--IILIT------TFSVLFVAGIAFAIPTVIS 322
Cdd:cd17335 238 LWTVGVVsEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENpwLVLPIellhglTFALVWAAAVSYASAAAPP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 323 KIGVVVknnQGFFLSV-NTFVLFLGTAIAPILMLFVGElSNFFLQFLMIAIVGLIALVV 380
Cdd:cd17335 318 GLRATA---QGLLQGLyFGLGGGLGSLIGGYLYEAFGA-RTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
65-384 |
5.08e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 5.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 65 GTISEKYGRIKT-ILVGMSALVIICLMIGIVHSFTVLLILRALQGVfAASFSPVVMTYTTETYPRVKRVTAISFISTSFM 143
Cdd:cd17490 52 GILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI-AAATWVSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 144 LSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESPHKNPDIQLIKFFnnFKDFKDNLKVFYCLFISLTLL 223
Cdd:cd17490 131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKEL--LSVLKDKKLLFFSLLAILQQM 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 224 IMFISMYDILNEYvtSHQVG-GDMSVSSMMKLFGVIGMLLSLLAGRV-SSRIGIKRLLTIALTTCIVSIILMGVTTNIIL 301
Cdd:cd17490 209 ITFSTTFGFTPLI--AKQLGaSSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 302 IttFSVLFVAGIAFAI--PTVISKIGVVVKNNQ-----GFFLSVNTFVLFLGtaiaPILMLFVGELSNFFLQFLMIAIVG 374
Cdd:cd17490 287 L--YLLQALNGFGTGIlfPLLMSLSIEGVPAEQrstamGFFQAIYALGMFLG----PVLVGIISEAFGLQTGFFVIGVIA 360
|
330
....*....|
gi 488368504 375 LIALVVSIFM 384
Cdd:cd17490 361 LLAAILSLAY 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-182 |
5.64e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 5.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 5 KNYNLITTIMFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSAL 84
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 85 VIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQW 164
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*...
gi 488368504 165 VYFILTILYLILVLVIYK 182
Cdd:cd06173 365 VFLLAGALLLLAALLLLL 382
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-229 |
9.66e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.15 E-value: 9.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 15 FISGIIVMASLYtALPLTATFA----EDFHvPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLM 90
Cdd:cd06179 1 AALCLAYFAQLF-GVTLPAAVLpfivADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 91 IGIVHSFTVLLILRALQGVfAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVV--SYLNWQWVYFI 168
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGI-GAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 169 LTILY---LILVLVIYKNVP-ESPHKNPDIQLIKFFnnfkDFkdnlkVFYCLFI-SLTLLIMFISM 229
Cdd:cd06179 158 NAIFNalaLILLFFFYHPPPrPQLHGSSTRQKLKRL----DW-----VGLFLLIaGLVLFLLGLSW 214
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
62-384 |
1.08e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.13 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRaLQGVFAASFSPVVMTYTTETYPRvKRVTAISFISTS 141
Cdd:cd17331 53 PLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMVVTDLTDPG-ERAAALGRLGLS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 142 FMLSGVLGQNMSELVVSYLNWQ---WVYFILTILYLILVLVIY--------KNVPESPHKNPDIQLIKFFNNFKDFKDNL 210
Cdd:cd17331 131 YGIGMVVGSFLGGLLTKKFGEQaaaLVAAVGSLLSIVLVILLIpsntkskrEKEAKESASPPSVFNLKEILRLLRLPGVA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 211 KVFYCLFISLTLLIMFISMYDIL--NEYVTSHQVGGdmsvsSMMKLFGVIGMLL-SLLAGRVSSRIGIKRLLTIALTTCI 287
Cdd:cd17331 211 FLLLVKLLSGLPIGMFQSMFSLVamDFFGLTPEENG-----YLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLA 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 288 VSIILMGVTTNI---ILITTFSVLFVAGIAFAIPTVISKigVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVgeLSNFF 364
Cdd:cd17331 286 IGYLLLAFVTTVwqlLVLLLPLVIGGSVLYTVITSLLTK--AVPPEDTGTALGLSHALFSLVRTVSPTIGGAL--LQAYG 361
|
330 340
....*....|....*....|.
gi 488368504 365 LQFL-MIAIVGLIALVVSIFM 384
Cdd:cd17331 362 FPSFgLLGAAINGLLTVYLLL 382
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
63-290 |
1.21e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 43.76 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 63 FYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSF 142
Cdd:PRK12307 72 LFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 143 MLSGVLGQNMSELVVSYLNWQWVYFIlTILYLILVLVIYKNVPESPHKNPDiqliKFFNNFKDFKDNLKVFYCLFISL-- 220
Cdd:PRK12307 152 GIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLLVIYIRARAPESKEWEEA----KLSGKGKHSQSAWSVFSLSMKGLfn 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 221 -----TLLIMFISMYDI------LNEYVTSHQVGGDMS---VSSMMKLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTC 286
Cdd:PRK12307 227 raqfpLTLCVFIVLFSIfganwpIFGLLPTYLAGEGFDtgvVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMS 306
|
....
gi 488368504 287 IVSI 290
Cdd:PRK12307 307 FLFI 310
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
254-385 |
1.37e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 254 LFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILIttFSVLFVAGIAFAI--PTVISKIGVVVKNN 331
Cdd:cd17478 39 VFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL--LLLVALAGIGSAAfhPEGARLASQAAGGR 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488368504 332 QGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17478 117 RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
52-377 |
1.47e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 52 LFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKR 131
Cdd:cd17312 46 AFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKER 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 132 VTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESPHknpdiqlikffnnfkdfkdnlk 211
Cdd:cd17312 126 GTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP---------------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 212 vfYCLFISLTLLIMFISMYDIL---NEYVTSHQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRI-GIKRLLTIALTTC- 286
Cdd:cd17312 184 --YVWVLSLAYAFVYIVRYACLdwgPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLl 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 287 -IVSIILMGVTTNIILIttfSVLFVAGIAFAIPTVISKIGVVV------KNNQGFFLSVNTFVLFLGTAIAPILMLFVGE 359
Cdd:cd17312 262 mTLSLALFWFFPHNKLL---SIVLLFLIGFFVGGPINLIGGAAaqdigrKEAAGTATGFVGLFGYLGASLAGLPLGYIID 338
|
330
....*....|....*...
gi 488368504 360 LSNFFLQFLMIAIVGLIA 377
Cdd:cd17312 339 HYGWSTVFYFLISAALLS 356
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
162-384 |
1.53e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.75 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 162 WQWVYFILTILYLILVLVIYKNVPE--SPHKNPDIQLiKFFNNFKDFKDNLKVFYCLFISLTLLIMFISMYDILNEYVTS 239
Cdd:cd17332 172 YFLTALIIGIIGIILLLICFFGTRErvVPPEEEKSKL-PLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKY 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 240 HQVGGDMSVSSMMkLFGVIGMLLSLLAGRVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPT 319
Cdd:cd17332 251 VLGGRAELVLLLL-LILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGAN 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 320 VI--SKIGVVV--------KNNQGFFLSVNTFVLFLGTAIA----PILMLFVGELSNFFLQ--------FLMIAIVGLIA 377
Cdd:cd17332 330 LLpwAMLADVIdygelktgKRREGIFYSVMTFFRKLGLALAgalvGLILSLAGYVANAAAQsasalngiRLLIAVLPAVL 409
|
....*..
gi 488368504 378 LVVSIFM 384
Cdd:cd17332 410 LLLALIL 416
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
50-188 |
1.83e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 43.37 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 50 GVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRV 129
Cdd:cd17438 40 GLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLARE 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 130 KRVTAISFISTSFMLSGVLGQNMSELVVSYLNW-----------QW-VYFILTILYLILVLVIYKNVPESP 188
Cdd:cd17438 120 KRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWgfsmgtnyhfhSWrVFVIICALPCIASIIALKFMPESP 190
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
45-187 |
1.95e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 43.26 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 45 IATLNGVLFsLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGvFAASFSPVVMTYTTE 124
Cdd:cd17441 36 VALLTSVVF-IGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVG-FGIGGVPQSVTLYAE 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488368504 125 TYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVyFILTILYLILVLVIYKNVPES 187
Cdd:cd17441 114 FLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWL-LILSALPLLIFAVLCFWLPES 175
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
20-380 |
3.17e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 20 IVMASLYTALPLTATF-AEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFT 98
Cdd:cd17475 6 AAASLVAQGIPALAPFlQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 99 VLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFI---LTILYLI 175
Cdd:cd17475 86 VLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVaglVSILAAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 176 LVLVIYKNVPESPHK----------------NPDIQLIKFFNnfkdfkdnlkvfyclfISLTLLIMFISMYDILneYVTS 239
Cdd:cd17475 166 LFWLFYREPPAASAAtesastllrslkevlrNRDVWLIAIAG----------------ALLVAPQFALLTFLLL--FLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 240 HQVGGDMSVSSMMKLFGVIGMLLSLLAGRVSSRIG----IKRLLTIALTTCIVSII---LMGVTTNIILITTFSVLFVAG 312
Cdd:cd17475 228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVlslLSPGTPLWLLVLLLILLGLFA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488368504 313 IAFAIPTVISKIGVVVKNNQGFFLSVNTFVLFLGTAIAP-ILMLFVGELSNFFLQFLMIAIVGLIALVV 380
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPpLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
30-188 |
3.71e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 42.25 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 30 PLTATFAEDFHVPESIATLNgVLFSLTYSI-------SCLFYGTISEKYGRIKTILVGMSALVIICLMIG---IVHSFTV 99
Cdd:cd17357 29 FINDTLVDRYGLNLSDSELD-LLWSLIVSIffiggaiGSFISAFLANRFGRKNGLLISNALLVVSSLLMFlskSAKSPEL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 100 LLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQ--NMSELVVSYLNWQWVYFILTILYLILV 177
Cdd:cd17357 108 LIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQvfGLPSVLGTETLWPYLLFFPGIPALLQL 187
|
170
....*....|.
gi 488368504 178 LVIYKnVPESP 188
Cdd:cd17357 188 AALPF-FPESP 197
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
51-179 |
4.67e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 4.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 51 VLFSLTYSISCLFYGTISEKY-GRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRV 129
Cdd:cd17490 237 IIYLLPNALASLLSGTLFYKKlGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAE 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488368504 130 KRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLV 179
Cdd:cd17490 317 QRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
79-279 |
7.89e-04 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 41.43 E-value: 7.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 79 VGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVS 158
Cdd:cd17486 73 ILLMAALIALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLAD 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 159 YLNWQWVYFILTILYLILVLVIY----KNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFyclfisltLLIMFISMYDILN 234
Cdd:cd17486 153 SLSWSAVYLIMAALMGPGILATLfapePPRTDPPANSLSETVVAFFAPFKDFFGQPGAL--------LILAFILLYKLGD 224
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 488368504 235 EYVTS-------HQVGGDMSVSSMMKLFGVIGMLL-SLLAGRVSSRIGIKRLL 279
Cdd:cd17486 225 AMLGAmatpfllDLGFTKTEIGAVYKTVGLIATIVgGLLGGFLMSRLGLKRSL 277
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
57-185 |
8.51e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 8.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 57 YSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIV--HSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTA 134
Cdd:cd17380 47 YALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRA 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488368504 135 ISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVP 185
Cdd:cd17380 127 VSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
62-189 |
9.38e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTS 141
Cdd:PRK11551 68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 488368504 142 FMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESPH 189
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRA 195
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
29-385 |
1.13e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 29 LPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQG 108
Cdd:cd17390 16 LPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 109 VFAASFSpVVMTYTTETYPRVKRVTAI----SFISTSFMLSGVLGQNMSELVVSYlnwQWVYFILTILYLILVLVIYKNV 184
Cdd:cd17390 96 IFKHTQS-LCKAYLSDLVSEQERSRVLgrfnAASSLGFILGPVVGGHLAETDGGF---YYVALLCSAIFILNAGLVWFLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 185 PESPhknpDIQLIKFFNNFKdfkdnlkvfyclfisltlLIMFISMYDILNEY---VTSHQVGGDMSVSsmmklfGVIGML 261
Cdd:cd17390 172 SKLW----DLLLVRFLMGFS------------------VLLFRSNFSLYLEErfdLSPKTIGYLISYS------GVLGAL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 262 LSLLAGRVSSRIGIKRLLTIALTTCI--VSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKNNQ-GFFLSV 338
Cdd:cd17390 224 SGFLVGRILKLYKNNEYLLLLHSFILlaLSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKErGTLLGV 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 488368504 339 NTFVLFLGTAIAPILMLFVGELSNfFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17390 304 GQSVTSLARILAPLLSGLLQEFSV-SGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
57-185 |
1.86e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.21 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 57 YSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGvFAASFSPVVMTYTTETYPRVKRVTAIS 136
Cdd:cd17372 47 MMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVG-LGLGGGPQLASWYLEFLPAKSRGTWMV 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 488368504 137 FISTSFMLSGVLGQNMSELVVSYLNWQWVyFILTILYLILVLVIYKNVP 185
Cdd:cd17372 126 LFSVFWTVGTIFEASLAWLVMPRLGWRWL-LAFSSVPSSLLLVFYRWTP 173
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
65-297 |
1.88e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 39.92 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 65 GTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVfAASFSPVVmTYTT--ETYPRVKRVTAISFISTSF 142
Cdd:PRK15402 69 GPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI-GLCFIGAV-GYAAiqESFEEADAIKITALMANVA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 143 MLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESPH-KNPDIQLIKFFNNFKDFKDNLKvFYCLFISLT 221
Cdd:PRK15402 147 LLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGrVGEKLSLKELGRDYKLVLKNRR-FVAGALALG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 222 L----LIMFISMYDIL---NEYVTSHQVGgdmsvssmMKLFGVIGMLLS--LLAGRVSSRIGIKRLLTIALTTCIVSIIL 292
Cdd:PRK15402 226 LvslpLLAWIALSPVIlisGEQLSSYEYG--------LLQVPVFGALIAgnLTLARLTSRRPLRSLIRMGLWPMVAGLLL 297
|
....*
gi 488368504 293 MGVTT 297
Cdd:PRK15402 298 AALAT 302
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
50-357 |
2.19e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.95 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 50 GVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSpVVMTYTTETYPRV 129
Cdd:cd17389 70 GSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPK 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 130 KRVTAISFISTSFMLSGVLG---------QNMSELVVSYLNWQWVYFILTILYLIlvlVIYKNVPESPHKNpdIQLIKFF 200
Cdd:cd17389 149 KRSKGMALIGVAFSLGFIIGpmigayfasFTRSLGEVFFSMPALFALVLALADLL---FIFFFLPETLPSN--LRRLGLV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 201 NNFKDFkdnlkVFYCLFISLTLLimfisMYDILNeyVTSHQVGgdmsvssmmKLFGVIGMLLSLLAGRVSSRI---GIKR 277
Cdd:cd17389 224 YFLYLF-----LFSGLEFTLTFL-----THQRFQ--YTSMQQG---------KMFFFIGIIMALVQGGYVRRIkpgKEKK 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 278 LLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIP---TVISKIGVVvkNNQGFFLSVNTFVLFLGTAIAPILM 354
Cdd:cd17389 283 AVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPcltTLVSGYGSD--DQKGTVMGIFRSLGALARALGPIVA 360
|
...
gi 488368504 355 LFV 357
Cdd:cd17389 361 CTV 363
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
44-136 |
2.28e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 44 SIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTT 123
Cdd:TIGR00895 285 SLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMA 364
|
90
....*....|...
gi 488368504 124 ETYPRVKRVTAIS 136
Cdd:TIGR00895 365 LFYPTAIRATGVG 377
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
31-188 |
2.63e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 39.52 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 31 LTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVF 110
Cdd:PRK10213 42 LLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLA 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 111 AASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPESP 188
Cdd:PRK10213 122 LGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLP 199
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
46-180 |
4.18e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 46 ATLNGVLFSLTYSISCLFYGTISEKYGR----IKTILVGMSALVIIClmigIVHSFTVLLILRALQGVFA--ASFSPVvm 119
Cdd:pfam06609 80 QGLFSTLWTMGQAVSILMMGRLTDRFGRrpfvIATHIIGLVGAIVGC----TANKFNTLLAAMTLLGVAAgpAGASPL-- 153
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488368504 120 tYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVI 180
Cdd:pfam06609 154 -FIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLI 213
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
79-380 |
6.33e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 79 VGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVS 158
Cdd:cd17485 74 LGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYD 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 159 YLNWQWVYFILTILYL--ILVLVIYKNVPESPHKNPDIQLIKFFNNFKDFKDNLKVFYCLFISLTL---LIMFISMYD-- 231
Cdd:cd17485 154 LIGWQSLLLSLAALYLllLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYklgEQGALAMLPpf 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 232 ILNEYVTSHQVGGDMSVSSMmkLFGVIGmllSLLAGRVSSRIGIKRLLTIALTT--------CIVSIILMGVTTNIILIT 303
Cdd:cd17485 234 LVDRGFSLSQIGLLSGVGGS--LVSIAG---SLLGGYLLKRRGRRRLLLLGGLLrllllglyTLLALGGSGLNWVLLLAS 308
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488368504 304 TFSVLFVAGIAF-AIPTVIskIGVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVV 380
Cdd:cd17485 309 LALLHLVGGMITtALFTLM--MDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLL 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
14-385 |
6.83e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 14 MFISGIIVMASLYTALPLTATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGI 93
Cdd:cd17352 8 SFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 94 VHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILY 173
Cdd:cd17352 88 ATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 174 LILVLVIYknvpesphknpdiqLIKFFNNFkdfkdnlkVFYCLFISLTL-LIMFISMYDILNEYVTSHQVgGDMSVSSMM 252
Cdd:cd17352 168 LNLCVCGL--------------LLRLLKDP--------TFVLLALGVSFaMLGFFVPFVYLPSYAKSLGI-DESDAAFLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 253 KLFGVIGMLLSLLAGRVSSRIGIKRLLT--IALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVISKIGVVVKN 330
Cdd:cd17352 225 SIIGISDIVGRILLGLLADKPRIGRLYLyiFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 331 NQ-----GFFLSVNTFVLFLGTaiaPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFMP 385
Cdd:cd17352 305 EKlsnayGLVLLFQGLAALVGP---PIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
16-110 |
7.90e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.21 E-value: 7.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 16 ISGIIVMASLYtalpltatFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVH 95
Cdd:COG2270 254 VQTVIAFAGIY--------AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLT 325
|
90
....*....|....*
gi 488368504 96 SFTVLLILRALQGVF 110
Cdd:COG2270 326 TALAFWILGLLIGLV 340
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
10-384 |
7.92e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.01 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 10 ITTIMFISGIiVMASLYTALPltaTFAEDFHVpeSIATLNGVLFSLTY--SISCLFYGTISEKYGRIKTILVGMSALVII 87
Cdd:cd17393 4 VAAFFFINGI-LMASWATRIP---AIKDRLGL--SDAALGLLLLALGVgaLVAMPLAGRLVARFGSRRVTRLGALLLLLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 88 CLMIGIVHSFTVLLILRALQGVFAASfSPVVMTYTTETYPRVKRVTAISFISTSFMLSGVLGQNMSELVVSYLNWQWVYF 167
Cdd:cd17393 78 LLLLGLAPSVPALALALFLFGAANGA-LDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 168 ILTILYLILVLVIYKN--VPESPHKNPDIQLIKFFNNFKdfkdnLKVFYCLFISLTLLIMFIS---MYDILNEYVTShQV 242
Cdd:cd17393 157 LAAAVLLLLAALVAIRalLPGTGEAAEDRPDGAGKPGFL-----LPNRLLLLLGLLALAAALAegaAADWSALYLRD-VL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 243 GGDMSVSSMMKLFGVIGMLLSLLAG-RVSSRIGIKRLLTIALTTCIVSIILMGVTTNIILITTFSVLFVAGIAFAIPTVI 321
Cdd:cd17393 231 GASAALAALGYAVFSLAMTVGRLFGdRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAF 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488368504 322 SKIGVVVKNNQGFFLSVNTFVLFLGTAIAPILMLFVGELSNFFLQFLMIAIVGLIALVVSIFM 384
Cdd:cd17393 311 SAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
65-187 |
8.51e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 37.88 E-value: 8.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 65 GTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISFISTSFML 144
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 488368504 145 SGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKNVPES 187
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
62-189 |
8.62e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 37.93 E-value: 8.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 62 LFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFAASFSPVVMTYTTETYPRVKRVTAISF---- 137
Cdd:cd17359 54 LFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlm 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488368504 138 ----ISTSFMLSGVLGQNMSELVVSYLNWQWVYFILTILYLILVLVIYKnVPESPH 189
Cdd:cd17359 134 ivfgQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF-IPESPR 188
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
32-131 |
9.70e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 37.99 E-value: 9.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488368504 32 TATFAEDFHVPESIATLNGVLFSLTYSISCLFYGTISEKYGRIKTILVGMSALVIICLMIGIVHSFTVLLILRALQGVFA 111
Cdd:cd17313 269 TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGW 348
|
90 100
....*....|....*....|
gi 488368504 112 ASFSPVVMTYTTETYPRVKR 131
Cdd:cd17313 349 ATININPYPLVSDYHSESGR 368
|
|
| |
