|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
4-1045 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 751.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 4 KLLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVK 83
Cdd:COG0841 2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 84 TESIPNASIVTVEYDNGTDMDKAEEQLKKEIDKIKFK--DGVGEPELTRNSMDAFPIVAYSFSSNNQKLKDVTNKLNQQL 161
Cdd:COG0841 82 STSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 162 VPKLQTIDGVQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSIIVDGQFKSVDAFK 241
Cdd:COG0841 162 KDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 242 NLKIplsisgqagqndsdsdndslmptdnnRTSNSSThmaqkgqmpsVPLKDLADISVG-DERTSISKTNGKDAVNLQIM 320
Cdd:COG0841 242 NIVI--------------------------RTNDGSV----------VRLGDVARVEDGaEDYRSIARLNGKPAVGLAIQ 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 321 KSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSI 399
Cdd:COG0841 286 KQPGANALEVADAVRAKLEELQASlPEGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAI 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 400 PMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSdpnEKLKGENLIISATREVFKPIMSSTLVTI 479
Cdd:COG0841 366 PVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDAIVVVENIERHME---EGLSPLEAAIKGAREVAGAVIASTLTLV 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 480 VVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNREQK------GGLGVVGRAYRSALNWS 553
Cdd:COG0841 443 AVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRffrafnRGFDRLTRGYGRLLRWA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 554 LNHKWIVLIVSIFILVGSVVIGARnLGTSYISTGDNKFLALTYTPKPGETQKSITQHAEKVQNYLDKKDKVETVQYSIGG 633
Cdd:COG0841 523 LRHRKLTLLVALALLALSVLLFGR-LPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGF 601
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 634 PTPqdpTGSTNSMAIMIKYQsdtpNFDEEPDKV----------LKHI-----ETFKQPGewknQDLGTGAGnnsVEVTVK 698
Cdd:COG0841 602 SGG---GSGSNSGTIFVTLK----PWDERDRSAdeiiarlrekLAKIpgarvFVFQPPA----GGLGSGAP---IEVQLQ 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 699 GPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGKSI 778
Cdd:COG0841 668 GDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREY 747
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 779 DVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTD-KDVGGKSQQVMAKVK 857
Cdd:COG0841 748 DVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPgVSLGEALAAIEELAA 827
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 858 DLEKPSHIKINVGGATDDIDKAISQLAMamiaaiiivylilviTFrgGLA-----------------PFTILFSLPFTVI 920
Cdd:COG0841 828 ELKLPPGVSIEFTGQAEEEQESFSSLGL---------------AF--LLAlllvylvlaaqfesfiqPLIILLTVPLALI 890
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 921 GVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLF 1000
Cdd:COG0841 891 GALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLAL 970
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*
gi 488377935 1001 GQDSSILISKGMAATVIGGLISSTLLTLFVVPVMYEILFTLKNKL 1045
Cdd:COG0841 971 GTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
5-1035 |
2.28e-178 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 547.66 E-value: 2.28e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 5 LLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVKT 84
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 85 ESIPNASIVTVEYDNGTDMDKAEEQLKKEIDKIKFK--DGVGEPELTRNSMDAFPIVAYSFSSNNQKLK--DVTNKLNQQ 160
Cdd:pfam00873 81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLlpEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTqtDLRDYADTN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 161 LVPKLQTIDGVQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSIIVDGQFKSVDAF 240
Cdd:pfam00873 161 IKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 241 KNLkiplSISGQAGQndsdsdndslmptdnnrtsnssthmaqkgqmpSVPLKDLADISVGDE-RTSISKTNGKDAVNLQI 319
Cdd:pfam00873 241 EKI----IVKNQDGS--------------------------------PVRLRDVATVELGSElYRGFATFNGKPAVGLGV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 320 MKSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVS 398
Cdd:pfam00873 285 QKLPGANAIETADAVRAKLAELKPTfPQGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 399 IPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDpnEKLKGENLIISATREVFKPIMSSTLVT 478
Cdd:pfam00873 365 IPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVENIERVLEE--NGLKPLEAAYKSMGEIGGALVAIALVL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 479 IVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKnREQKGGLGVVGR-------AYRSALN 551
Cdd:pfam00873 443 SAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVALTLTPALCATLLKPRRE-PKHGGFFRWFNRmfdrltrGYAKLLA 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 552 WSLNHKWIVLIVSIFILVGSVVIGARnLGTSYISTGDNKFLALTYTPKPGETQKSITQHAEKVQNYLDKKDKVETVQYSI 631
Cdd:pfam00873 522 KVLRHTAVVLLVALLLVVGSVWLFVR-IPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVT 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 632 GGPTPQDPTGSTNSMA-IMIKYQSDTPNFDEEPDKVLKHIET-----------FKQPGEWknQDLGTGAGNNS-VEVTVK 698
Cdd:pfam00873 601 GFAFSGDNNGPNSGDAfISLKPWKERPGPEKSVQALIERLRKalkqipganvfLFQPIQL--RGLGTISGFRSdLQVKIF 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 699 GPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGKSI 778
Cdd:pfam00873 679 GDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVY 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 779 DVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTDKDVGGKSQQVMAK-VK 857
Cdd:pfam00873 759 DVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQiAK 838
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 858 DLEKPSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPS 937
Cdd:pfam00873 839 QVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYA 918
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 938 LIGMLMLIGIVVTNAIVLIDrVIN--NEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLF--GQDSSILisKGMA 1013
Cdd:pfam00873 919 QVGLILLIGLAVKNAILMVE-FANelREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALstGAGSELQ--QPLG 995
|
1050 1060
....*....|....*....|..
gi 488377935 1014 ATVIGGLISSTLLTLFVVPVMY 1035
Cdd:pfam00873 996 IVVFGGLVTSTVLTLLVVPVFY 1017
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1038 |
3.53e-149 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 471.44 E-value: 3.53e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 1 MIKKLLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVN 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 81 SVKTESIPNASIVTVEYDNGTDMDKAE----EQLKKEIDKIKfkDGVgEPELTrnsmdafP-------IVAYSFSSNNQK 149
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDIYWARqlvlERLQQVREQLP--AGV-TPELG-------PistglgeIYQYTLESDPGK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 150 --LKDVTNKLNQQLVPKLQTIDGVqnAQLN--GQTNREVslkfkQKNLD-EK----GLTANDVENYIKTATRETPLGLFq 220
Cdd:COG3696 151 ysLMELRTLQDWVIRPQLRSVPGV--AEVNsfGGFVKQY-----QVLVDpAKlrayGLTLDDVIEALERNNANVGGGYI- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 221 fNKSNKSIIV--DGQFKSVDAFKNlkIPLsisgqagqndsdsdndslmptdnnrtsnssthmAQKGQMPsVPLKDLADIS 298
Cdd:COG3696 223 -ERGGQEYLVrgIGLIRSLEDIEN--IVV---------------------------------KTRNGTP-VLLRDVAEVR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 299 VG-DERTSISKTNGK-DAVNLQIMKSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGT 375
Cdd:COG3696 266 IGpAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAVKAKLAELKPSlPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGA 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 376 IVAIIVILLFLRNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDPNEKLK 455
Cdd:COG3696 346 LLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRRLEENRAAGT 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 456 GEN---LIISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKN 532
Cdd:COG3696 426 PRErleVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPE 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 533 REQKgglgVVG---RAYRSALNWSLNHKWIVLIVSIFILVGSVVIGARnLGTSYIST---GDnkfLALTYTPKPG---ET 603
Cdd:COG3696 506 KENP----LVRwlkRLYRPLLRWALRHPKLVLAVALVLLVLALALFPR-LGSEFLPEldeGD---LLVMATLPPGislEE 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 604 QKSITQHAEKVqnyLDKKDKVETVQYSIG-GPTPQDPTGSTNS-MAIMIKYQSDTPNfDEEPDKVLKHIE---------- 671
Cdd:COG3696 578 SVELGQQVERI---LKSFPEVESVVSRTGrAEDATDPMGVNMSeTFVILKPRSEWRS-GRTKEELIAEMRealeqipgvn 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 672 -TFKQPGEWKNQDLGTGAgnnSVEVTVK--GPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADN 748
Cdd:COG3696 654 fNFSQPIQMRVDELLSGV---RADVAVKifGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARY 730
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 749 GISAAQLAMNLNENLPEKTISTVNEKGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQE 828
Cdd:COG3696 731 GLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRE 810
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 829 DGDYATTVTGKVTDKDVGGKSQQVMAKV-KDLEKPSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLA 907
Cdd:COG3696 811 NGRRRIVVQANVRGRDLGSFVAEAQAKVaEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRD 890
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 908 PFTILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMT 987
Cdd:COG3696 891 ALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPVLMT 970
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|...
gi 488377935 988 AIATIGALVPLLFGQD--SSILisKGMAATVIGGLISSTLLTLFVVPVMYEIL 1038
Cdd:COG3696 971 ALVAALGLLPMALSTGpgSEVQ--RPLATVVIGGLITSTLLTLLVLPALYLLF 1021
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
15-1038 |
3.68e-131 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 422.89 E-value: 3.68e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 15 AIFLMVvLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVKTESIPNASIVT 94
Cdd:NF033617 11 TLLLSL-LILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTIT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 95 VEYDNGTDMDKAEEQLKKEIDKIKFK--DGVGEPELTR--NSMDAfPIVAYSFSSNNQKLKDVTNKLNQQLVPKLQTIDG 170
Cdd:NF033617 90 LQFRLGTDLDVALSEVQAAINAAQSLlpSEAPDPPVYRkaNSADT-PIMYIGLTSEEMPRGQLTDYAERVLAPKLSQING 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 171 VQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLF--QFNKSNKSiiVDGQFKSVDAFKNLKIPLS 248
Cdd:NF033617 169 VGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVrgDSVVSTVR--ANDQLKTAEDYEDLVIKYA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 249 ISGQAgqndsdsdndslmptdnnrtsnssthmaqkgqmpsVPLKDLADISVGDERT-SISKTNGKDAVNLQIMKSQDANT 327
Cdd:NF033617 247 DNGAP-----------------------------------VRLGDVATVELGAENVrNRAWANGVPAVVLGINRQPGANP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 328 VQVAREVQKKVDEFVRNESGMKSIKTMDTAKP-----IEDSLYTMVEKAALgtivAIIVILLFLRNIRTTAISIVSIPMS 402
Cdd:NF033617 292 IEVADEIRALLPELQETLPKNIKVNVLYDRTRfirasIDEVESTLLEAVAL----VILVVFLFLRNLRATLIPAVTVPLS 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 403 ILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSdpneklKGENLIISA---TREVFKPIMSSTLVTI 479
Cdd:NF033617 368 LIGTFAVMYLFGFSINLLTLMALVLAIGLVVDDAIVVVENIHRHIE------EGESPLEAAlkgAREIGFTVIAMTLTLV 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 480 VVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVK----NREQKGGLGVVGRAYRSALNWSLN 555
Cdd:NF033617 442 AVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLTPMMCSRLLKANEKpgrfARAVDRFFDGLTARYGRGLKWVLK 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 556 HKWIVLIVSIFILVGSVvigarnLGTSYISTG-----DNKFLALTYTPKPGETQKSITQHAEKVQNYLDKKDKVETVQ-Y 629
Cdd:NF033617 522 HRPLTLVVALATLALLP------LLYVFIPKElapseDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTsF 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 630 SIGGPTPQDPTGstnSMAIMIKYQSDTpnfDEEPDKVLKHIETF--KQPGE----WKNQDL--GTGAGNNSVEVTVKGPN 701
Cdd:NF033617 596 NGVGGNPGDNTG---FGIINLKPWDER---DVSAQEIIDRLRPKlaKVPGMdlflFPLQDLpgGAGSSLPQYQVTLTPSD 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 702 TSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGKSIDVK 781
Cdd:NF033617 670 YDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVV 749
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 782 VKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTDKDVGGKSQQVMAKVKDLEK 861
Cdd:NF033617 750 LEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELL 829
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 862 PSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPSLIGM 941
Cdd:NF033617 830 PSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGL 909
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 942 LMLIGIVVTNAIVLIDRVINNEK-QGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGMAATVIGGL 1020
Cdd:NF033617 910 ITLIGLVKKNGILMVEFANELQRhQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGL 989
|
1050
....*....|....*...
gi 488377935 1021 ISSTLLTLFVVPVMYEIL 1038
Cdd:NF033617 990 GVGTLFTLFVLPVVYLLL 1007
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1048 |
8.57e-97 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 330.57 E-value: 8.57e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 1 MIKKLLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVN 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 81 SVKTESIPNASIVTVEYDNGTDMDKAEEQLKKEIDKIKFK--DGVgEPELTRNSMDAFPIVAYSFSSNNQKLKDVTNKLN 158
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNlpEGV-SPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 159 QQ---------LVPKLQTIDGVQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSII 229
Cdd:TIGR00914 160 LTdlrtiqdwiIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 230 VDGQFKSVDAFKNLKIplsisgqagqndsdsdndslmptdnnrtsnssthmaQKGQMPSVPLKDLADISVGDE-RTSISK 308
Cdd:TIGR00914 240 APGQVQSMDDIRNIVI------------------------------------ATGEGVPIRIRDVARVQIGKElRTGAAT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 309 TNGKDAVNLQIMKSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLR 387
Cdd:TIGR00914 284 ENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTlPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLG 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 388 NIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALtvAIGRVIDDSIVVVENIFRRLSDPNEKLkGENL-------- 459
Cdd:TIGR00914 364 NIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLtlkerlhe 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 460 IISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNREQKGGL 539
Cdd:TIGR00914 441 VFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMR 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 540 gVVGRAYRSALNWSLNHKWIVLIVSIFILVGSVVIGARnLGTSYISTGDNKFLALTYTPKPGetqKSITQHAEkVQNYLD 619
Cdd:TIGR00914 521 -VLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASR-VGGEFIPSLNEGDLAYQALRIPG---TSLAQSVA-MQQTLE 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 620 KKDK----VETVQYSIG----GPTPQDPTGSTNSmaIMIKYQSDTPNFDEEPDKVLKHIET-----------FKQPGEWK 680
Cdd:TIGR00914 595 KLIKsfpeVARVFAKTGtaeiATDPMPPNASDTY--IILKPESQWPEGKKTKEDLIEEIQEatvripgnnyeFTQPIQMR 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 681 NQDLGTGAgNNSVEVTVKGPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLN 760
Cdd:TIGR00914 673 FNELISGV-RSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVA 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 761 ENLPEKTISTVNEKGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGG-----TIKLSEIASLKKSYTPSKLTQEDGDYATT 835
Cdd:TIGR00914 752 TAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENGKRRVV 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 836 VTGKVTDKDVGGKSQQVMAKVKDLEK-PSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFS 914
Cdd:TIGR00914 832 VSANVRGRDLGSFVDDAKKAIAEQVKlPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTG 911
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 915 LPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGA 994
Cdd:TIGR00914 912 IPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLG 991
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....
gi 488377935 995 LVPLLFGQDSSILISKGMAATVIGGLISSTLLTLFVVPVMYEILFTLKNKLTKK 1048
Cdd:TIGR00914 992 FVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLVHRRRHKGRKE 1045
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
16-1044 |
2.47e-85 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 298.18 E-value: 2.47e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 16 IFLMV--VLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQ---VRSLAYVNSvkTESIPNA 90
Cdd:TIGR00915 10 IFAWViaIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNmngIDGLRYMSS--SSDSDGS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 91 SIVTVEYDNGTDMDKAEEQLKKEIDkikfkdgVGEPEL-----------TRNSMDAFPIVAYSFSSNNQKLKDVTNKLNQ 159
Cdd:TIGR00915 88 MTITLTFEQGTDPDIAQVQVQNKLQ-------LATPLLpqevqrqgvrvEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 160 QLVPKLQTIDGVQNAQLNGqTNREVSLKFKQKNLDEKGLTANDVENYIKTATREtplglfqfnksnksiIVDGQFKSVDA 239
Cdd:TIGR00915 161 NMVDPLSRLEGVGDVQLFG-SQYAMRIWLDPAKLNSYQLTPADVISAISAQNAQ---------------ISAGQLGGLPA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 240 FKNLKIPLSISGQaGQNDSDSDNDSLMPTDNNRTSNssthmaqkgqmpsVPLKDLADISVGDERTSIS-KTNGKDAVNLQ 318
Cdd:TIGR00915 225 VPGQQLNATIIAQ-TRLQTPEQFENILLKVNTDGSQ-------------VRLKDVARVELGGENYSISaRFNGKPASGLA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 319 IMKSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIV 397
Cdd:TIGR00915 291 IKLATGANALDTAKAVKAELAVLEPFfPQGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTI 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 398 SIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDPNEKLKgenliiSATREVFKPI----MS 473
Cdd:TIGR00915 371 AVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVMAEEGLPPK------EATRKSMGQIqgalVG 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 474 STLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNR--EQKGG--------LGVVG 543
Cdd:TIGR00915 445 IAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIEKGEhhEKKGGffgwfnrmFDSST 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 544 RAYRSALNWSLNHKWIVLIVSIFILVGSVVIGARnLGTSYISTGDNK-FLALTYTPkPGETQKSITQHAEKVQNYL--DK 620
Cdd:TIGR00915 525 HGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR-LPTSFLPDEDQGvFMTIVQLP-AGATAERTQAVLAQVTKYLlaKE 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 621 KDKVETVqYSIGGptpQDPTGSTNSMAIMIKYQSDTPNFDEEPDKVLKHIETFKQP-GEWKN-----------QDLGTGA 688
Cdd:TIGR00915 603 KANVESV-FTVNG---FSFAGRGQNMGMAFIRLKDWEERTGKENSVFAIAGRATGHfMQIKDamviafvppaiLELGNAT 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 689 GNNSVEVTVKGPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTI 768
Cdd:TIGR00915 679 GFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYV 758
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 769 STVNEKGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTdkdVGGK 848
Cdd:TIGR00915 759 NDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAA---PGVS 835
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 849 SQQVMAKVKDLEK--PSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLAL 926
Cdd:TIGR00915 836 TGQAMAAMEAIAQklPPGFGFSWTGMSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLAT 915
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 927 IITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSI 1006
Cdd:TIGR00915 916 TLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGS 995
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 488377935 1007 LISKGMAATVIGGLISSTLLTLFVVPVMYEI---LFTLKNK 1044
Cdd:TIGR00915 996 GSQHAIGTGVFGGMVTATVLAIFFVPLFYVVvrrLFKRKAH 1036
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
15-1049 |
8.19e-72 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 258.89 E-value: 8.19e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 15 AIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVKTESIPNASIVT 94
Cdd:PRK10503 22 ATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVIT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 95 VEYDNGTDMDKAEEQLKKEID---KIKFKDGVGEPELTR-NSMDAfPIVAYSFSSNNQKLKDVTNKLNQQLVPKLQTIDG 170
Cdd:PRK10503 102 LQFQLTLPLDVAEQEVQAAINaatNLLPSDLPNPPVYSKvNPADP-PIMTLAVTSTAMPMTQVEDMVETRVAQKISQVSG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 171 VQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSIIVDGQFKSVDAFKNLKIplsis 250
Cdd:PRK10503 181 VGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLII----- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 251 gqAGQNDSdsdndslmptdnnrtsnssthmaqkgqmpSVPLKDLADISVGDERTSISK-TNGKDAVNLQIMKSQDANTVQ 329
Cdd:PRK10503 256 --AYQNGA-----------------------------PIRLGDVATVEQGAENSWLGAwANKQQAIVMNVQRQPGANIIA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 330 VAREVQKKVDEFVrnESGMKSIKT---MDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSIPMSILIA 406
Cdd:PRK10503 305 TADSIRQMLPQLT--ESLPKSVKVtvlSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGT 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 407 LIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSdpneklKGENLIISATR---EVFKPIMSSTLVTIVVFL 483
Cdd:PRK10503 383 FAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIE------KGEKPLAAALKgagEIGFTIISLTFSLIAVLI 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 484 PLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGV---KNREQKGGLGVVGR---AYRSALNWSLNHK 557
Cdd:PRK10503 457 PLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSQESlrkQNRFSRASERMFDRviaAYGRGLAKVLNHP 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 558 WIVLIVSIFILVGSVVIGArNLGTSYISTGDNKFLALTYTPKPGETQKSITQHAEKVQNYLDKKDKVETVQYSIG--GPT 635
Cdd:PRK10503 537 WLTLSVALSTLLLTVLLWI-FIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGvdGTN 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 636 PqdptgSTNSMAIMIKYQSdtpnFDEEPDKVLKHIETFKQ-----PGE----WKNQDL--GTGAGNNSVEVTVKGPNTSA 704
Cdd:PRK10503 616 P-----SLNSARLQINLKP----LDERDDRVQKVIARLQTavakvPGVdlylQPTQDLtiDTQVSRTQYQFTLQATSLDA 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 705 MKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGKSIDVKVKQ 784
Cdd:PRK10503 687 LSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEH 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 785 NKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTDK-DVGGKSQQVMAKVKDLEKPS 863
Cdd:PRK10503 767 NTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGySLGDAVQAIMDTEKTLNLPA 846
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 864 HIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPSLIGMLM 943
Cdd:PRK10503 847 DITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIIL 926
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 944 LIGIVVTNAIVLIDRVINNEK-QGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGMAATVIGGLIS 1022
Cdd:PRK10503 927 LIGIVKKNAIMMIDFALAAEReQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIV 1006
|
1050 1060
....*....|....*....|....*..
gi 488377935 1023 STLLTLFVVPVMYEILFTLKNKLTKKF 1049
Cdd:PRK10503 1007 SQVLTLFTTPVIYLLFDRLALYTKSRF 1033
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
15-1048 |
1.62e-70 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 255.04 E-value: 1.62e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 15 AIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVKTESIPNASIVT 94
Cdd:PRK10614 13 ATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 95 VEYDNGTDMDKAEEQLKKEIDKIKFKDGVGEPELTR----NSMDAfPIVAYSFSSNNQKLKDVTNKLNQQLVPKLQTIDG 170
Cdd:PRK10614 93 LQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTyrkaNPSDA-PIMILTLTSDTYSQGQLYDFASTQLAQTISQIDG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 171 VQNAQLNGQTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSIIVDGQFKSVDAFKnlkiPLSIS 250
Cdd:PRK10614 172 VGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQ----PLIIH 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 251 GQAGQndsdsdndslmptdnnrtsnssthmaqkgqmpSVPLKDLADI--SVGDERTSiSKTNGKDAVNLQIMKSQDANTV 328
Cdd:PRK10614 248 YNNGA--------------------------------AVRLGDVATVtdSVQDVRNA-GMTNAKPAILLMIRKLPEANII 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 329 QVAREVQKKVDEFvrNESGMKSIK---TMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSIPMSILI 405
Cdd:PRK10614 295 QTVDRIRAKLPEL--RETIPAAIDlqiAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIG 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 406 ALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLsdpNEKLKGENLIISATREVFKPIMSSTLVTIVVFLPL 485
Cdd:PRK10614 373 TFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHL---EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPL 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 486 VFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKnGVKNREQKG--GLG----VVGRAYRSALNWSLNHKWI 559
Cdd:PRK10614 450 LLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMCAWLLK-SSKPREQKRlrGFGrmlvALQQGYGRSLKWVLNHTRW 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 560 VLIVSIFILVGSVVIgarnlgtsYIStgdnkfLALTYTPKPG--------ETQKSITQHA--EKVQNYL---DKKDKVET 626
Cdd:PRK10614 529 VGVVLLGTIALNVWL--------YIS------IPKTFFPEQDtgrlmgfiQADQSISFQAmrGKLQDFMkiiRDDPAVDN 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 627 VQYSIGGptpqdptGSTNS--MAIMIKYQSDTpnfDEEPDKVLKH--IETFKQPGE----WKNQDLGTGA--GNNSVEVT 696
Cdd:PRK10614 595 VTGFTGG-------SRVNSgmMFITLKPLSER---SETAQQVIDRlrVKLAKEPGAnlflMAVQDIRVGGrqSNASYQYT 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 697 VKGPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGK 776
Cdd:PRK10614 665 LLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLN 744
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 777 SIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKV-TDKDVGGKSQQVMAK 855
Cdd:PRK10614 745 QYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLpTGKSLSDASAAIERA 824
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 856 VKDLEKPSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISV 935
Cdd:PRK10614 825 MTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSL 904
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 936 PSLIGMLMLIGIVVTNAIVLIDRVINNEKQG-MQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGMAA 1014
Cdd:PRK10614 905 IALIGIMLLIGIVKKNAIMMVDFALEAQRNGnLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGI 984
|
1050 1060 1070
....*....|....*....|....*....|....
gi 488377935 1015 TVIGGLISSTLLTLFVVPVMYEILFTLKNKLTKK 1048
Cdd:PRK10614 985 TIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRK 1018
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
21-1038 |
5.04e-67 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 244.74 E-value: 5.04e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 21 VLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSVKTESIPNASIVTVEYDNG 100
Cdd:PRK09579 19 LLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSIISIYARIG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 101 TDMDKAEEQLKKEIDKIKFK--DGVGEPELTRNSMDAFPIVAYSFSSNNQKLKDVTNKLNQQLVPKLQTIDGVQNAQLNG 178
Cdd:PRK09579 99 ADSDRLFTELLAKANEVKNQlpQDAEDPVLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPKLATLPGMAEAEILG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 179 QTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNKSIIVDGQFKSVDAFKnlKIPLSISGqagqnds 258
Cdd:PRK09579 179 NQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFA--AIPVKTSG------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 259 dsdnDSlmptdnnrtsnssthmaqkgqmpSVPLKDLADISVGDER-TSISKTNGKDAVNLQIMKSQDANTVQVAREVQKK 337
Cdd:PRK09579 250 ----DS-----------------------RVLLGDVARVEMGAENyDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 338 VDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSIPMSILIALIALKLSNVS 416
Cdd:PRK09579 303 MPELESQlPPNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYS 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 417 LNILTLGALTVAIGRVIDDSIVVVENIFRRLSDPNEKLKGEnliISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMF 496
Cdd:PRK09579 383 INLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGKSPFDAA---LEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALF 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 497 RPFALAITFSLLASLLVSITLVPSLGATFfkngVKNREQKGGLG--------VVGRAYRSALNWSLNHKWIVLIVSIFIL 568
Cdd:PRK09579 460 KEFALTLAGAVIISGIVALTLSPMMCALL----LRHEENPSGLAhrldrlfeRLKQRYQRALHGTLNTRPVVLVFAVIVL 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 569 VGSVVI--------------GARNLGTSYISTGDNKFLAlTYTPKPGETQKSITQHAEKVQ-NYLDKkdkvetVQYSIGG 633
Cdd:PRK09579 536 ALIPVLlkftqselapeedqGIIFMMSSSPQPANLDYLN-AYTDEFTPIFKSFPEYYSSFQiNGFNG------VQSGIGG 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 634 --PTPQDPTGSTNsMAIMIKYQSdtpNFDEEPDkvlKHIETFKQPGEwknqdLGTGAGNNSVEVTVKGPNTSAMKDTVNR 711
Cdd:PRK09579 609 flLKPWNERERTQ-MELLPLVQA---KLEEIPG---LQIFGFNLPSL-----PGTGEGLPFQFVINTANDYESLLQVAQR 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 712 VEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTVNEKGKSIDVKVKQNKQTDWS 791
Cdd:PRK09579 677 VKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDN 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 792 SQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGkVTDKDVGGKSQQVMAKVKDlEKPSHIKINVGG 871
Cdd:PRK09579 757 PGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAIISG-FPIVSMGEAIETVQQIARE-EAPEGFAFDYAG 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 872 ATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTN 951
Cdd:PRK09579 835 ASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKH 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 952 AIVLIDRVIN-NEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSIlISKGMAATVIG-GLISSTLLTLF 1029
Cdd:PRK09579 915 GILIVEFANQlRHEQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGA-VSRFDIGLVIAtGMSIGTLFTLF 993
|
....*....
gi 488377935 1030 VVPVMYEIL 1038
Cdd:PRK09579 994 VLPCIYTLL 1002
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
14-1044 |
1.76e-60 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 225.09 E-value: 1.76e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 14 FAiFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQ---VRSLAYVNSvkTESIPNA 90
Cdd:PRK10555 11 FA-WVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNmtgLDNLMYMSS--QSSGTGQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 91 SIVTVEYDNGTDMDKAEEQLKKEIDKI--KFKDGVGEPELTRNSMDAFPIVAYSFSSNNQKL--KDVTNKLNQQLVPKLQ 166
Cdd:PRK10555 88 ASVTLSFKAGTDPDEAVQQVQNQLQSAmrKLPQAVQNQGVTVRKTGDTNILTIAFVSTDGSMdkQDIADYVASNIQDPLS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 167 TIDGVQNAQLNGqTNREVSLKFKQKNLDEKGLTANDVENYIKtatretplglfqfnkSNKSIIVDGQFKSVDAFKNLKIP 246
Cdd:PRK10555 168 RVNGVGDIDAYG-SQYSMRIWLDPAKLNSFQMTTKDVTDAIE---------------SQNAQIAVGQLGGTPSVDKQALN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 247 LSISGQagqndsdsdndSLMPTDNnRTSNSSTHMAQKGQMpsVPLKDLADISVGDER-TSISKTNGKDAVNLQIMKSQDA 325
Cdd:PRK10555 232 ATINAQ-----------SLLQTPE-QFRDITLRVNQDGSE--VTLGDVATVELGAEKyDYLSRFNGKPASGLGVKLASGA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 326 NTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAK----PIEDSLYTMVEKAALgtivAIIVILLFLRNIRTTAISIVSIP 400
Cdd:PRK10555 298 NEMATAKLVLNRLDELAQYfPHGLEYKVAYETTSfvkaSIEDVVKTLLEAIAL----VFLVMYLFLQNFRATLIPTIAVP 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 401 MSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDpnEKLKGEnliiSATREVFKPIMSS----TL 476
Cdd:PRK10555 374 VVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERIMSE--EGLTPR----EATRKSMGQIQGAlvgiAM 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 477 VTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVK--NREQKGGLGVVGRAY-RSALNWS 553
Cdd:PRK10555 448 VLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVLVAMILTPALCATLLKPLKKgeHHGQKGFFGWFNRMFnRNAERYE 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 554 ------LNH--KWIVLIVsifILVGSVVIGARNLGTSYISTGDNKFLALTYTPKPGETQKSITQHAEKVQNYL--DKKDK 623
Cdd:PRK10555 528 kgvakiLHRslRWILIYV---LLLGGMVFLFLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYftHEKDN 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 624 VETVQYSIGGptpqDPTGSTNSMAIMIKYQSDTPNFDEEPDKVLKHIE----TFKQPGEWKN--------QDLGTGAGNN 691
Cdd:PRK10555 605 VMSVFATVGS----GPGGNGQNVARMFIRLKDWDERDSKTGTSFAIIEratkAFNKIKEARViassppaiSGLGSSAGFD 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 692 SVEVTVKGPNTSAMKDTVNRVEKMMTDIKGITNVKSDLSQTYDQYEIKVDQNKAADNGISAAqlamNLNENLPEKTIST- 770
Cdd:PRK10555 681 MELQDHAGAGHDALMAARNQLLALAAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSID----DINDTLQTAWGSSy 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 771 VNE---KGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTDKDVGG 847
Cdd:PRK10555 757 VNDfmdRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTG 836
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 848 KSQQVMAK-VKDLekPSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLAL 926
Cdd:PRK10555 837 TAMDIMESlVKQL--PNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLAT 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 927 IITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSI 1006
Cdd:PRK10555 915 WMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGS 994
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 488377935 1007 LISKGMAATVIGGLISSTLLTLFVVPVMYEIL---FTLKNK 1044
Cdd:PRK10555 995 GSQHAVGTGVMGGMISATILAIFFVPLFFVLVrrrFPLKPR 1035
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
16-1035 |
6.67e-60 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 223.63 E-value: 6.67e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 16 IFLMVVLII--LGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKID---NQVRSLAYVNSVKTESipNA 90
Cdd:PRK15127 10 IFAWVIAIIimLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEqnmNGIDNLMYMSSNSDST--GT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 91 SIVTVEYDNGTDMDKAEEQLKkeiDKIKFKDGVGEPELTRN------SMDAFPIVAYSFSSN-NQKLKDVTNKLNQQLVP 163
Cdd:PRK15127 88 VQITLTFESGTDADIAQVQVQ---NKLQLAMPLLPQEVQQQgvsvekSSSSFLMVVGVINTDgTMTQEDISDYVAANMKD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 164 KLQTIDGVQNAQLNGqTNREVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLF------QFNKSNKSIIVDGQFKSV 237
Cdd:PRK15127 165 PISRTSGVGDVQLFG-SQYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLggtppvKGQQLNASIIAQTRLTST 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 238 DAFKnlKIPLSISGQAGQndsdsdndslmptdnnrtsnssthmaqkgqmpsVPLKDLADISVGDERTS-ISKTNGKDAVN 316
Cdd:PRK15127 244 EEFG--KILLKVNQDGSR---------------------------------VRLRDVAKIELGGENYDiIAEFNGQPASG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 317 LQIMKSQDANTVQVAREVQ---KKVDEFVrnESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTA 393
Cdd:PRK15127 289 LGIKLATGANALDTAAAIRaelAKMEPFF--PSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATL 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 394 ISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDPNEKLKgenliiSATREVFKPIMS 473
Cdd:PRK15127 367 IPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPK------EATRKSMGQIQG 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 474 S----TLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNREQKGGLGVVG------ 543
Cdd:PRK15127 441 AlvgiAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGwfnrmf 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 544 ----RAYRSALNWSLNHKWIVLIVSIFILVGSVVIGARnLGTSYISTGDNK-FLALTYTPKpGETQKSITQHAEKVQNY- 617
Cdd:PRK15127 521 ekstHHYTDSVGNILRSTGRYLVLYLIIVVGMAYLFVR-LPSSFLPDEDQGvFLTMVQLPA-GATQERTQKVLNEVTDYy 598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 618 LDK-KDKVETVqYSIGGPTPQDPTGSTNSMAIMIKYQSDTPNFDEE-PDKVLKHIETFKQPGEW--------KNQDLGTG 687
Cdd:PRK15127 599 LTKeKNNVESV-FAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKvEAITMRATRAFSQIKDAmvfafnlpAIVELGTA 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 688 AGNNSVEVTVKGPNTSAMKDTVNRVEKMMT---DIkgITNVKSDLSQTYDQYEIKVDQNKAADNGISAAQLAMNLNENLP 764
Cdd:PRK15127 678 TGFDFELIDQAGLGHEKLTQARNQLLGEAAkhpDM--LVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWG 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 765 EKTISTVNEKGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDYATTVTGKVTDKD 844
Cdd:PRK15127 756 GSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGK 835
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 845 VGGKSQQVMAKVKDlEKPSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVL 924
Cdd:PRK15127 836 STGEAMELMEELAS-KLPTGVGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALL 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 925 ALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVIN-NEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQD 1003
Cdd:PRK15127 915 AATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDlMDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSG 994
|
1050 1060 1070
....*....|....*....|....*....|..
gi 488377935 1004 SSILISKGMAATVIGGLISSTLLTLFVVPVMY 1035
Cdd:PRK15127 995 AGSGAQNAVGTGVMGGMVTATVLAIFFVPVFF 1026
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
14-1038 |
9.56e-57 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 213.56 E-value: 9.56e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 14 FAiFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKID---NQVRSLAYVNSvkTESIPNA 90
Cdd:PRK09577 11 FA-WVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEremNGAPGLLYTSA--TSSAGQA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 91 SIvTVEYDNGTDMDKAEEQLKKEIDKIKFKdgvgEPELTR-------NSMDAFPIVAySFSSNNQKLKDVT--NKLNQQL 161
Cdd:PRK09577 88 SL-SLTFKQGVNADLAAVEVQNRLKTVEAR----LPEPVRrdgiqveKAADNIQLIV-SLTSDDGRLTGVElgEYASANV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 162 VPKLQTIDGVQNAQLNGQtnrEVSLKF--KQKNLDEKGLTANDVENYIKTATRETPLGlfQFNKS--------NKSIIVD 231
Cdd:PRK09577 162 LQALRRVEGVGKVQFWGA---EYAMRIwpDPVKLAALGLTASDIASAVRAHNARVTIG--DIGRSavpdsapiAATVFAD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 232 GQFKSVDAFKNlkIPLSISGQAGqndsdsdndslmptdnnrtsnssthmaqkgqmpSVPLKDLADISVG-DERTSISKTN 310
Cdd:PRK09577 237 APLKTPEDFGA--IALRARADGS---------------------------------ALYLRDVARIEFGgNDYNYPSYVN 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 311 GKDAVNLQIMKSQDANTVQVAREVQKKVDEFVRN-ESGMKSIKTMDTAKPIEDSLYTMVEKAALGTIVAIIVILLFLRNI 389
Cdd:PRK09577 282 GKTATGMGIKLAPGSNAVATEKRVRATMDELSRYfPPGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNF 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 390 RTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRRLSDpnEKLKGENLIISATREVFK 469
Cdd:PRK09577 362 RATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVDDAIVVVENVERLMVE--EGLSPYDATVKAMKQISG 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 470 PIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNREQKGG-LGVVGRA--- 545
Cdd:PRK09577 440 AIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAFLALSLTPALCATLLKPVDGDHHEKRGfFGWFNRFvar 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 546 ----YRSALNWSLNH--KWIVLIVSIfilVGSVVIGARNLGTSYISTGDN-KFLALTYTPKpGETQKSITQHAEKVQNYL 618
Cdd:PRK09577 520 stqrYATRVGAILKRplRWLVVYGAL---TAAAALLFTRLPTAFLPDEDQgNFMVMVIRPQ-GTPLAETMQSVREVESYL 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 619 DKKDKVETVqYSIGGPTPQDpTGSTNSM-------------------AIMIKYQSdtpNFDEEPDKVLKHIETFKQPG-- 677
Cdd:PRK09577 596 RRHEPVAYT-FALGGFNLYG-EGPNGGMifvtlkdwkerkaardhvqAIVARINE---RFAGTPNTTVFAMNSPALPDlg 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 678 -----EWKNQDLGtGAGNNSVEVTVKGPNTSAMKDTVnrvekmmtdikgITNVKSDLSQTYDQYEIKVDQNKAADNGISA 752
Cdd:PRK09577 671 stsgfDFRLQDRG-GLGYAAFVAAREQLLAEGAKDPA------------LTDLMFAGTQDAPQLKLDIDRAKASALGVSM 737
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 753 AQLAMNLNENLPEKTISTVNEKGKSIDVKVKQNKQTDWSSQKIKNIKLNKPTGGTIKLSEIASLKKSYTPSKLTQEDGDY 832
Cdd:PRK09577 738 DEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYP 817
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 833 ATTVTGKVTdkdVGGKSQQVMAKVKDLEK--PSHIKINVGGATDDIDKAISQLAMAMIAAIIIVYLILVITFRGGLAPFT 910
Cdd:PRK09577 818 SFTINGSAA---PGHSSGEAMAAIERIAAtlPAGIGYAWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFA 894
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 911 ILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIA 990
Cdd:PRK09577 895 VMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLA 974
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*...
gi 488377935 991 TIGALVPLLFGQDSSILISKGMAATVIGGLISSTLLTLFVVPVMYEIL 1038
Cdd:PRK09577 975 FGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVV 1022
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-521 |
4.64e-32 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 135.23 E-value: 4.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 3 KKLLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISVQTTMSGATPQSTQDEISSKIDNQVRSLAYVNSV 82
Cdd:COG0841 516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 83 KT-------ESIPNASIVTVEYDNGTDMDKA----EEQLKKEIDKIK----FKDGVGEPELTRNSmdafPIVAYSFSSNN 147
Cdd:COG0841 596 FSvvgfsggGSGSNSGTIFVTLKPWDERDRSadeiIARLREKLAKIPgarvFVFQPPAGGLGSGA----PIEVQLQGDDL 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 148 QKLKDVTnklnQQLVPKLQTIDGVQNAQLNGQTNR-EVSLKFKQKNLDEKGLTANDVENYIKTATRETPLGLFQFNKSNK 226
Cdd:COG0841 672 EELAAAA----EKLLAALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREY 747
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 227 SIIV---DGQFKSVDAFKNLKIplsisgqagqndsdsdndslmptdnnRTSNssthmaqkGQMpsVPLKDLADISVGDER 303
Cdd:COG0841 748 DVRVqapEEDRNSPEDLENLYV--------------------------RTPD--------GEM--VPLSSVATIEEGTGP 791
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 304 TSISKTNGKDAVNLQIMKSQDANTVQVAREVQKKVDEFVRnESGMkSIKTMDTAKPIEDSLYTMVekaaLGTIVAIIVIL 383
Cdd:COG0841 792 SSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELKL-PPGV-SIEFTGQAEEEQESFSSLG----LAFLLALLLVY 865
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 384 LFL----RNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVE--NIFRRlsdpneklKGE 457
Cdd:COG0841 866 LVLaaqfESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDfaNQLRE--------EGM 937
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488377935 458 NL---IISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSITLVPSL 521
Cdd:COG0841 938 SLreaILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVL 1004
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
322-1048 |
1.06e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 120.73 E-value: 1.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 322 SQDANTVQVAREVQKKVDEFVRNE-----SGMkSIKTMDTAKPIEDSLYTMVekaALGTIVAIIVILLFLRNIRTTAISI 396
Cdd:COG1033 174 SSDLDRKEVVAEIRAIIAKYEDPGvevylTGF-PVLRGDIAEAIQSDLAIFF---PLALLLILLLLFLFFRSLRGVLLPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 397 VSIPMSILIALIALKLSNVSLNILT--LGALTVAIGrvIDDSIVVVeNIFRRlsdpnEKLKGEN---LIISATREVFKPI 471
Cdd:COG1033 250 LVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIG--IDYGIHLL-NRYRE-----ERRKGLDkreALREALRKLGPPV 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 472 MSSTLVTIVVFLPLVFvSGSvgEMFRPFALAITFSLLASLLVSITLVPSLgATFFKNGVKNREQKGGLGVVGRAYRSALN 551
Cdd:COG1033 322 LLTSLTTAIGFLSLLF-SDI--PPIRDFGIVAAIGVLLAFLTSLTLLPAL-LSLLPRPKPKTRRLKKPPELGRLLAKLAR 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 552 WSLNHKWIVLIVSIFILVGSvVIGARNLGTSYistGDNKFLaltytpkPGETQksITQHAEKVQNYLdkkdkvetvqysi 631
Cdd:COG1033 398 FVLRRPKVILVVALVLAVVS-LYGISRLKVEY---DFEDYL-------PEDSP--IRQDLDFIEENF------------- 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 632 ggptpqdptGSTNSMAIMIKyqSDTPNFDEEPDkVLKHIEtfkqpgewknqdlgtgagnnsvevtvkgpntsamkdtvnR 711
Cdd:COG1033 452 ---------GGSDPLEVVVD--TGEPDGLKDPE-VLKEID---------------------------------------R 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 712 VEKMMTDIKGITNVKSdLSQTYDQYEIKVDQNKAADNGI----SAAQLAMNLNENLPEKTIST-VNEKGKS--IDVKVKq 784
Cdd:COG1033 481 LQDYLESLPEVGKVLS-LADLVKELNQALNEGDPKYYALpesrELLAQLLLLLSSPPGDDLSRfVDEDYSAarVTVRLK- 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 785 nkqtDWSSQKIKNIklnkptggtikLSEIASLKKSYTPSKltqedgDYATTVTGKVTdkdvggksqqVMAKVKDLEKPSH 864
Cdd:COG1033 559 ----DLDSEEIKAL-----------VEEVRAFLAENFPPD------GVEVTLTGSAV----------LFAAINESVIESQ 607
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 865 IKINVGGATddidkAISQLamamiaaiiivyliLVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPSLIGMLML 944
Cdd:COG1033 608 IRSLLLALL-----LIFLL--------------LLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIA 668
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 945 IGIVVTNAIVLIDRVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFgqdSSILISKGMAATVIGGLISST 1024
Cdd:COG1033 669 LGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVAL 745
|
730 740
....*....|....*....|....
gi 488377935 1025 LLTLFVVPVMyeiLFTLKNKLTKK 1048
Cdd:COG1033 746 LAALLLLPAL---LLLLDPRIAKK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
320-533 |
5.41e-18 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 89.53 E-value: 5.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 320 MKSQDANTVqvaREVQKKVDEFVRNESGMKSIKTMDTAKPI--EDSLYTMVEKAALGTIVAIIVILLFL----RNIRTTA 393
Cdd:COG1033 557 LKDLDSEEI---KALVEEVRAFLAENFPPDGVEVTLTGSAVlfAAINESVIESQIRSLLLALLLIFLLLllafRSLRLGL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 394 ISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIFRrlsdpnEKLKGENL---IISATREVFKP 470
Cdd:COG1033 634 ISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYRE------ERRKGGDLeeaIRRALRTTGKA 707
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488377935 471 IMSSTLVTIVVFLPLVFvsgSVGEMFRPFALAITFSLLASLLVSITLVPSLGATFFKNGVKNR 533
Cdd:COG1033 708 ILFTSLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
4-521 |
7.61e-14 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 76.18 E-value: 7.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 4 KLLQFSLGNKFAIFLMVVLIILGGVYSSAKLKLELLPDVENPVISvqtTMSGATPQSTQDEISSKIDNQVRSLAYVNSVK 83
Cdd:pfam00873 518 KLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEGVFV---TSAQLPPGVSLDQTQRVMKQVEKILKEKPEVE 594
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 84 ------------TESIPNASIVTVEYD-----NGTDMDKAE--EQLKKEIDKIKFKD--GVGEPELTRNSM---DAFPIV 139
Cdd:pfam00873 595 svfavtgfafsgDNNGPNSGDAFISLKpwkerPGPEKSVQAliERLRKALKQIPGANvfLFQPIQLRGLGTisgFRSDLQ 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 140 AYSFSSNNQKLkdvtNKLNQQLVPKLQTIDGVQNAQLNGQTN-REVSLKFKQKNLDEKGLTANDVENYIKTAtretpLG- 217
Cdd:pfam00873 675 VKIFGDDLDAL----DEARNQILAALAQLPGLSDVRSDGQEDqPQLQVNIDREKAARLGVSIQDINDTLSTA-----LGg 745
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 218 -----LFQFNKSNKSII-VDGQFK-SVDAFKNLKIPLSisgqagqndsdsdndslmptdnnrtsnssthmaqKGQMpsVP 290
Cdd:pfam00873 746 syvndFPEGGRVYDVVVqLPEDFRsSPEDIGQLYVRNP----------------------------------YGKM--IP 789
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 291 LKDLADISVGDERTSISKTNGKDAVNLqimkSQDANTVQVAREVQKKVDefvRNESGMKSIKTMDtakpIEDSLYTMVEK 370
Cdd:pfam00873 790 LSAFAKIEWGYGPPSINRYNGFRSIVI----SGNVAAGDSLGDAMEAMA---QIAKQVKLPPGYG----YTWTGQFEQEQ 858
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 371 AALGTIVAIIVILLFL---------RNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVE 441
Cdd:pfam00873 859 LAGNSLPILIALALLVvflvlaalyESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVE 938
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 442 NIfrrlsdpNEKLKGENL-----IISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSIT 516
Cdd:pfam00873 939 FA-------NELREQEGKsleeaILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLL 1011
|
....*
gi 488377935 517 LVPSL 521
Cdd:pfam00873 1012 VVPVF 1016
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
695-1050 |
2.35e-13 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 74.76 E-value: 2.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 695 VTVKGPNTS--AMKDTV-NRVEKMMTDIKGITNVKSDLSQTYdQYEIKVDQNKAADNGISAAQLAMNLNENLPEKTISTV 771
Cdd:COG0841 141 LALSSDDLDelELSDYAeRNIKDRLERVPGVGQVQIFGGRER-EIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRI 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 772 NEKGKSIDVKVKQNKQTdwsSQKIKNIKLNKPTGGTIKLSEIASLkksytpsKLTQEDGDYATTVTG---------KVTD 842
Cdd:COG0841 220 GGGDREYTVRTNGRLKT---PEEFENIVIRTNDGSVVRLGDVARV-------EDGAEDYRSIARLNGkpavglaiqKQPG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 843 KDVGGKSQQVMAKVKDLEK--PSHIKINVGG-ATDDIDKAISQLamamiaaiiivylilVITFRGGL------------- 906
Cdd:COG0841 290 ANALEVADAVRAKLEELQAslPEGVELTIVYdQSEFIRASIEEV---------------VKTLLEAIllvvlvvflflrs 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 907 --APFTILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVL---IDRVINnekQGMQMKSALIEagGTR- 980
Cdd:COG0841 355 wrATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDAIVVvenIERHME---EGLSPLEAAIK--GARe 429
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488377935 981 -IRPILMTAIATIGALVPLLFGQDSSILISKGMAATVIGGLISSTLLTLFVVPVMYEILF-----TLKNKLTKKFN 1050
Cdd:COG0841 430 vAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTPALCARLLkphpkGKKGRFFRAFN 505
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
317-519 |
2.44e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 61.55 E-value: 2.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 317 LQIMKSQDANTVQVAREVQKKVDEFVRNESGMksiktmdtakPIE--DSLYTMVE---KAALGTIVAIIVILLF-LRNIR 390
Cdd:TIGR03480 668 LEVFPKEDLNDNEALRRFVRAVRKVAPDATGA----------PVSilESGDTVVGaflQAFIYALVAITVLLLLtLRRVR 737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 391 TTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENiFRRLSDPneklkgENLIISAT-REVFk 469
Cdd:TIGR03480 738 DVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHR-WRNGVDS------GNLLQSSTaRAVF- 809
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 488377935 470 pimSSTLVTIVVFLPLVFVS----GSVGEMfrpFALAITFSLLASLLVSITLVP 519
Cdd:TIGR03480 810 ---FSALTTATAFGSLAVSShpgtASMGIL---LSLGLGLTLLCTLIFLPALLG 857
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
328-592 |
1.42e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 59.08 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 328 VQVAREVQKKVdEFVRNESGMKSIKTMDTA---KPIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSIPMSIL 404
Cdd:TIGR00921 154 VPIYNDVERSL-ERTNPPSGKFLDVTGSPAinyDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVA 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 405 IALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVEnifRRLSDPNEKLKGENLIISATREVFKPIMSSTLVTIVVFLP 484
Cdd:TIGR00921 233 WVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLN---RYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 485 LvfvSGSVGEMFRPFALAITFSLLASLLVSITLVPSLGATF----FKNGVKNREQKGGLGVVGRAYRSALNWSLNHKWIV 560
Cdd:TIGR00921 310 L---ALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIdigrEKVKKEIIAIGGKSSEIEEELSKVLSITVRHPVPA 386
|
250 260 270
....*....|....*....|....*....|..
gi 488377935 561 LIVSiFILVGSVVIGARNLGtsyISTGDNKFL 592
Cdd:TIGR00921 387 LVAA-LIITGLGLYGAAGIK---PEVNIEKFI 414
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
370-587 |
4.57e-08 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 57.08 E-value: 4.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 370 KAALGTIVAIIVILLF-LRNIRTTAISIVSIPMSILIALIAL-------KLSNVSLNILTLgaLTVAIGrvIDDSIVVVe 441
Cdd:COG2409 173 RAELITLPVALVVLLLvFRSLVAALLPLLTAGLAVGVALGLLallaaftDVSSFAPNLLTM--LGLGVG--IDYALFLV- 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 442 NIFRRlsdpnEKLKGENL---IISATREVFKPIMSSTLVTIVVFLPLVFVSGSvgeMFRPFALAITFSLLASLLVSITLV 518
Cdd:COG2409 248 SRYRE-----ELRAGEDReeaVARAVATAGRAVLFSGLTVAIALLGLLLAGLP---FLRSMGPAAAIGVAVAVLAALTLL 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488377935 519 PSL----GATFFKNGVKNREQKGGLGvvGRAYRSALNWSLNHKWIVLIVSIFILVGsVVIGARNLGTSYISTG 587
Cdd:COG2409 320 PALlallGRRVFWPRRPRRRRAAAPE--SGFWRRLARAVVRRPVPVLVAAVAVLLA-LALPALGLRLGLPDAD 389
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
370-521 |
8.76e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 52.29 E-value: 8.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 370 KAALGTIVAIIVILLFL-RNIRTTAISIVSIPMSILIAL---------IALKLSNVSLNILTlgALTVAIGrvIDDSIVV 439
Cdd:pfam03176 146 LIEAVTLVVIFIILLIVyRSVVAALLPLLTVGLSLGAAQglvailahiLGIGLSTFALNLLV--VLLIAVG--TDYALFL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 440 V----ENIfRRLSDPNEKlkgenlIISATREVFKPIMSSTLVTIVVFLPLVFvsgSVGEMFRPFALAITFSLLASLLVSI 515
Cdd:pfam03176 222 VsryrEEL-RAGEDREEA------VIRAVRGTGKVVTAAGLTVAIAMLALSF---ARLPVFAQVGPTIAIGVLVDVLAAL 291
|
....*.
gi 488377935 516 TLVPSL 521
Cdd:pfam03176 292 TLLPAL 297
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
372-575 |
4.18e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.01 E-value: 4.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 372 ALGTIVAIIVILLFLRNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSI-VVVEnifrrlSDP 450
Cdd:COG4258 256 LISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLGFGSSLIGVAVDYSLhYLTH------RRA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 451 NEKLKGENLIisatREVFKPIMSSTLVTIVVFLPLVFvSGSvgEMFRPFAL-AITfSLLASLLVSITLVPSLgatffkng 529
Cdd:COG4258 330 AGEWDPRAAL----RRIWPTLLLGLLTTVLGYLALLF-SPF--PGLRQLGVfAAA-GLLAAALTTLLWLPLL-------- 393
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 488377935 530 VKNREQKGGLGVVGRAYRSALNWSLNHKWIVLIVSIFILVGSVVIG 575
Cdd:COG4258 394 LPRAAPRPPAPALALLARLLARWPRRLRWLLALLAVLALASLLGLN 439
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
370-515 |
4.48e-06 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 48.41 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 370 KAALGTIVAIIVILLFLRNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVvvenIFRRLSD 449
Cdd:TIGR00916 51 IALLIGLVLVLLYMLLRYEWRGAIAAIAALVHDVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVV----IFDRIRE 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 450 PNEKLKGENL---IISATREVFKPIMSSTLVTIVVFLPL-VFVSGSVgemfRPFALAITFSLLASLLVSI 515
Cdd:TIGR00916 127 ELRKYKGRTFreaINLGINQTLSRIIDTNVTTLLAVLALyVFGGGAI----KGFALTLGIGVIAGTYSSI 192
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
374-509 |
1.23e-05 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 49.45 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 374 GTIVAIIVILLF--LRNIRTTAISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVE--NIFRRlsd 449
Cdd:PRK09579 851 GLALAIIFLVLAaqFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEfaNQLRH--- 927
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488377935 450 pNEKLKGENLIISATREVFKPIMSSTLVTIVVFLPLVFVSG-----------------SVGEMFRPFALAITFSLLA 509
Cdd:PRK09579 928 -EQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGagavsrfdiglviatgmSIGTLFTLFVLPCIYTLLA 1003
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
373-521 |
6.97e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 6.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 373 LGTIVAIIVILLFLRNIRTTAISIVSIPMSILIALIALKLSNV--SLNILTLGALTVAIGrvIDDSIVVVENIFRRLSDP 450
Cdd:TIGR00921 575 AGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIpsFLAMATTISIILGLG--MDYSIHLAERYFEERKEH 652
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488377935 451 NEKlkgeNLIISATREVFKPIMSSTLVTIVVFLPLVFvsgSVGEMFRPFALAITFSLLASLLVSITLVPSL 521
Cdd:TIGR00921 653 GPK----EAITHTMERTGPGILFSGLTTAGGFLSLLL---SHFPIMRNFGLVQGIGVLSSLTAALVVFPAL 716
|
|
| SecD_SecF |
pfam02355 |
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ... |
367-515 |
7.72e-05 |
|
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.
Pssm-ID: 280510 [Multi-domain] Cd Length: 189 Bit Score: 44.52 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 367 MVEKAALGTIVAIIVIL--LFLRNIRTTAI-SIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVvvenI 443
Cdd:pfam02355 29 LARKAVLALLFALLLILiyVGLRFEWRFALgAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSVNDTVV----V 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488377935 444 FRRLSDPNEKLKGENLIISATREVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFRPFALAITFSLLASLLVSI 515
Cdd:pfam02355 105 FDRVRENLRKKTRATLNEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVGVIVGTYSSI 176
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
292-515 |
2.01e-04 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 45.61 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 292 KDLADISVGDERTSISKTNGKDaVNLQIMKSQDANTvQVAREVQKKVDEFVRNESGMKSIKTMDTAKPIEDSLytmVEKA 371
Cdd:PRK13024 505 ADLKELGLGEVNIVTFGSDNNQ-VLVRTYGILSDDE-EADTEIVAKLKNALKNDKGGTIPSSETVGPTVGKEL---ARNA 579
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 372 ALGTIVAIIVILLFLrNIR---TTAIS-IVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIfRRL 447
Cdd:PRK13024 580 IIAVLIALIGILLYI-LIRfewTFSLGaILALLHDVLIVIGFFSLFRLEVDLTFIAAILTIIGYSINDTVVVFDRI-REN 657
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488377935 448 SDPNEKLKGENLIISATREVFKPIMSSTLVTIVVFLPLVFVSGSVgemFRPFALAITFSLLASLLVSI 515
Cdd:PRK13024 658 LRLYKKKDLREIVNKSINQTLSRTINTSLTTLLVLLALLIFGGSS---LRNFSLALLVGLIVGTYSSI 722
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
367-437 |
2.92e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.84 E-value: 2.92e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488377935 367 MVEKAALGTIVAIIVILLFLRNIRTTAisIVSIPM--SILIALIALKLSNVSLNILTLGALTVAIGRVIDDSI 437
Cdd:COG4258 641 ALWLLLLALLLILLLLLLRLRSLRRAL--RVLLPPllAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL 711
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
368-635 |
1.50e-03 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 42.53 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 368 VEKAALGTIVAIIVILLF-LRNIRTT-AISIVSIPMSILIALIALKLSNVSLNILTLGALTVAIGRVIDDSIVVVENIfr 445
Cdd:PRK13024 265 IDAGIIAGIIGFALIFLFmLVYYGLPgLIANIALLLYIFLTLGALSSLGAVLTLPGIAGLVLGIGMAVDANVLIFERI-- 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 446 rlsdpNEKLKGENLIISATREVFKPIMSSTL---VT--IVVFLPLVFVSGSVgemfRPFALAITFSLLASLLVSITLVPS 520
Cdd:PRK13024 343 -----KEELRKGKSLKKAFKKGFKNAFSTILdsnITtlIAAAILFFFGTGPV----KGFATTLIIGILASLFTAVFLTRL 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 521 LGATFfkngVKNREQKGGLGVVGRAYRSAL--------NWSL--NHKWIVLIVSIFILVGSVVIGARNL--------GTS 582
Cdd:PRK13024 414 LLELL----VKRGDKKPFLFGVKKKKIHNInegvtifdRIDFvkKRKWFLIFSIVLVIAGIIIFFIFGLnlgidftgGTR 489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 583 Y----------------------------ISTGDNKFLALTYTPKPGETQKSITQHAEKVQNYLDKKDKVETVQYSIGGP 634
Cdd:PRK13024 490 YeirtdqpvdleqvradlkelglgevnivTFGSDNNQVLVRTYGILSDDEEADTEIVAKLKNALKNDKGGTIPSSETVGP 569
|
.
gi 488377935 635 T 635
Cdd:PRK13024 570 T 570
|
|
| AglD2 |
COG0392 |
Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis] ... |
359-542 |
3.31e-03 |
|
Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440161 Cd Length: 289 Bit Score: 40.70 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 359 PIEDSLYTMVEKAALGTIVAIIVILLFLRNIRTTAISIVSIPMSILIALIAlklsnVSLNILTLGALTVAIGRVIDDSIV 438
Cdd:COG0392 77 PAGKAAAIVALERLTDLLGLLLLAGLGLLFGPGALPGLGNLPGALLLLLLG-----LALLAAVLLYLLLLAFRPRLLLRL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 439 VVENIFRRLSDPNEKLKGENLIISAT-REVFKPIMSSTLVTIVVFLPLVFVSGSVGEMFrPFALAITFSLLASLLVSITL 517
Cdd:COG0392 152 RRWKLLRKIREKLERFLEGLRRLRLSpRLLLLQLLLSLLDWLLAALILYFLLPALGVDV-SFLAVLAVFLLASLAGLLPP 230
|
170 180
....*....|....*....|....*
gi 488377935 518 VPslgatffkngvknreqkGGLGVV 542
Cdd:COG0392 231 TP-----------------GGLGVF 238
|
|
| PRK13024 |
PRK13024 |
bifunctional preprotein translocase subunit SecD/SecF; Reviewed |
914-1048 |
6.15e-03 |
|
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
Pssm-ID: 237276 [Multi-domain] Cd Length: 755 Bit Score: 40.60 E-value: 6.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 914 SLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINN--EKQGMQMKSALIEAGGTRIRPILMTAIAT 991
Cdd:PRK13024 609 ALLHDVLIVIGFFSLFRLEVDLTFIAAILTIIGYSINDTVVVFDRIRENlrLYKKKDLREIVNKSINQTLSRTINTSLTT 688
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488377935 992 IGALVPLL-FGQDSSIliskGMAATVIGGLISSTLLTLFV-VPVMYeilFTLKNKLTKK 1048
Cdd:PRK13024 689 LLVLLALLiFGGSSLR----NFSLALLVGLIVGTYSSIFIaAPLWL---DLEKRRLKKK 740
|
|
| SecD_SecF |
pfam02355 |
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ... |
908-1030 |
6.66e-03 |
|
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.
Pssm-ID: 280510 [Multi-domain] Cd Length: 189 Bit Score: 38.74 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 908 PFTILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINN--EKQGMQMKSALIEAGGTRIRPIL 985
Cdd:pfam02355 57 ALGAIIALAHDVIITVGVFSLFGIEVDLATVAALLTIIGYSVNDTVVVFDRVRENlrKKTRATLNEIMNLSINQTLTRTI 136
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 488377935 986 MTAIATIGALVPLLFGQDSSIlisKGMAATVIGGLISSTLLTLFV 1030
Cdd:pfam02355 137 NTSLTTLLVVVALFVFGGGSL---KDFSLALLVGVIVGTYSSIFI 178
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
811-1034 |
7.47e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.21 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 811 SEIASLKKSYTPSKLTQEDGDYATT--VTGKVTDKDvggkSQQVMAKVKDLEK-------PSHIKINVGGA---TDDIDK 878
Cdd:TIGR00921 114 PEVRPLMSEYPRSKEMFLSKDHTVAiiIVQLKSDAD----YKQVVPIYNDVERslertnpPSGKFLDVTGSpaiNYDIER 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 879 AI-SQLAMAMIAAIIIVYLILVITFRGGLAPFTILFSLPFTVIGVVLALIITGETISVPSLIGMLMLIGIVVTNAIVLID 957
Cdd:TIGR00921 190 EFgKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLN 269
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488377935 958 RVINNEKQGMQMKSALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSIL-ISKGMAAtvigGLISSTLLTLFVVPVM 1034
Cdd:TIGR00921 270 RYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSeFGLGLVA----GLITAYLLTLLVLPAL 343
|
|
| PRK14726 |
PRK14726 |
protein translocase subunit SecDF; |
918-1043 |
7.96e-03 |
|
protein translocase subunit SecDF;
Pssm-ID: 237805 [Multi-domain] Cd Length: 855 Bit Score: 40.09 E-value: 7.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488377935 918 TVIGVVLAL---IITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEKQGMQMK-SALIEAG--GTRIRPILmTAIAT 991
Cdd:PRK14726 705 TLHDVILTLglfVLTGIEFNLTSIAAILTIVGYSLNDTVVVYDRVRENLRRYKKMPlPILIDASinQTLSRTVL-TSATT 783
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488377935 992 IGALVPL-LFGQDssilISKGMAATVIGGLISSTLLTLFVV-PVMyeILFTLKN 1043
Cdd:PRK14726 784 LLALLALyLFGGE----VIRSFTFAMLFGVAVGTFSSIYIAaPVL--IVFKLRP 831
|
|
| |
