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Conserved domains on  [gi|488388173|ref|WP_002457558|]
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global transcriptional regulator SarA [Staphylococcus epidermidis]

Protein Classification

SarA family transcriptional regulator( domain architecture ID 17609204)

SarA family transcriptional regulator similar to staphylococcal accessory regulators SarA, SarS, SarT, SarU, SarX

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TF_SarA NF038268
global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a ...
 1-121 4.14e-68

global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a transcription factor affecting multiple virulence-associated processes, such as biofilm formation and protease secretion.


:

Pssm-ID: 439568  Cd Length: 121  Bit Score: 200.82  E-value: 4.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173   1 MAISKINDCFELLAMVTYADRLKGIIKKEFSISFEEFAVLTYISENKEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYF 80
Cdd:NF038268   1 MAISKINDCFELLAMVTYADKLKSIIKKEFSISFEEFAVLTYISENKEEEYYLKDIINHLNYKQPQVVKAVKNLSQEDYF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488388173  81 NKKRNEHDERTVLILVDSKQRKKIDDLLKRVNNRITEANNE 121
Cdd:NF038268  81 DKRRNEHDERTVLILVNKKQRKKINELLERVNKRIKEANIE 121
 
Name Accession Description Interval E-value
TF_SarA NF038268
global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a ...
 1-121 4.14e-68

global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a transcription factor affecting multiple virulence-associated processes, such as biofilm formation and protease secretion.


Pssm-ID: 439568  Cd Length: 121  Bit Score: 200.82  E-value: 4.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173   1 MAISKINDCFELLAMVTYADRLKGIIKKEFSISFEEFAVLTYISENKEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYF 80
Cdd:NF038268   1 MAISKINDCFELLAMVTYADKLKSIIKKEFSISFEEFAVLTYISENKEEEYYLKDIINHLNYKQPQVVKAVKNLSQEDYF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488388173  81 NKKRNEHDERTVLILVDSKQRKKIDDLLKRVNNRITEANNE 121
Cdd:NF038268  81 DKRRNEHDERTVLILVNKKQRKKINELLERVNKRIKEANIE 121
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 10-116 1.61e-26

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 95.01  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173   10 FELLAMVTYADRLKGIIKKEFSISFEEFAVLTYIS--ENKEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEH 87
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGklENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*....
gi 488388173   88 DERTVLILVDSKQRKKIDDLLKRVNNRIT 116
Cdd:TIGR01889  81 DERKVIISINKEQRSKIESLISEIEQIIK 109
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-117 2.77e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.57  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173    26 IKKEFSISFEEFAVLTYISEnkEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDERTVLILVDSKQRKKID 105
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYE--EGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90
                   ....*....|..
gi 488388173   106 DLLKRVNNRITE 117
Cdd:smart00347  80 QLLEARSETLAE 91
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-90 9.52e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 9.52e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488388173   32 ISFEEFAVLTYISENKEDeyYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDER 90
Cdd:pfam12802   3 LTPAQFRVLLALARNPGL--TVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
28-118 2.61e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173  28 KEFSISFEEFAVLTYISENkeDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDERTVLILVDSKQRKKIDDL 107
Cdd:COG1846   32 AELGLTPAQFRVLAALAEA--GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEA 109

                         90
                 ....*....|.
gi 488388173 108 LKRVNNRITEA 118
Cdd:COG1846  110 RPALEALLAEL 120
 
Name Accession Description Interval E-value
TF_SarA NF038268
global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a ...
 1-121 4.14e-68

global transcriptional regulator SarA; SarA (staphylococcal accessory regulator) is a transcription factor affecting multiple virulence-associated processes, such as biofilm formation and protease secretion.


Pssm-ID: 439568  Cd Length: 121  Bit Score: 200.82  E-value: 4.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173   1 MAISKINDCFELLAMVTYADRLKGIIKKEFSISFEEFAVLTYISENKEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYF 80
Cdd:NF038268   1 MAISKINDCFELLAMVTYADKLKSIIKKEFSISFEEFAVLTYISENKEEEYYLKDIINHLNYKQPQVVKAVKNLSQEDYF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488388173  81 NKKRNEHDERTVLILVDSKQRKKIDDLLKRVNNRITEANNE 121
Cdd:NF038268  81 DKRRNEHDERTVLILVNKKQRKKINELLERVNKRIKEANIE 121
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 10-116 1.61e-26

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 95.01  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173   10 FELLAMVTYADRLKGIIKKEFSISFEEFAVLTYIS--ENKEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEH 87
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGklENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*....
gi 488388173   88 DERTVLILVDSKQRKKIDDLLKRVNNRIT 116
Cdd:TIGR01889  81 DERKVIISINKEQRSKIESLISEIEQIIK 109
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-117 2.77e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.57  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173    26 IKKEFSISFEEFAVLTYISEnkEDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDERTVLILVDSKQRKKID 105
Cdd:smart00347   2 ELKPLGLTPTQFLVLRILYE--EGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIE 79

                           90
                   ....*....|..
gi 488388173   106 DLLKRVNNRITE 117
Cdd:smart00347  80 QLLEARSETLAE 91
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-90 9.52e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 9.52e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488388173   32 ISFEEFAVLTYISENKEDeyYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDER 90
Cdd:pfam12802   3 LTPAQFRVLLALARNPGL--TVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
28-118 2.61e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388173  28 KEFSISFEEFAVLTYISENkeDEYYLKDIINHLNYKQPQVVKAVKNLSQENYFNKKRNEHDERTVLILVDSKQRKKIDDL 107
Cdd:COG1846   32 AELGLTPAQFRVLAALAEA--GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALLEEA 109

                         90
                 ....*....|.
gi 488388173 108 LKRVNNRITEA 118
Cdd:COG1846  110 RPALEALLAEL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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