|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-383 |
9.90e-71 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 226.32 E-value: 9.90e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 -TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTIFAIVMIFIA 170
Cdd:cd17489 81 aTSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 171 VTTTLFGYRTTFANTQKEVAPKEEVLPFnamtvyvQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIFL 250
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRAF-------RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 251 TIQAITVVIARFYLRKYVPsdglWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYLSFVL 330
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSD----RKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488388729 331 PKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIF 383
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-383 |
1.33e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.68 E-value: 1.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 -TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIA-VGIWHVENMTIFAIVMIFI 169
Cdd:cd17325 81 aTSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGgLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 170 AVTTTLfgyRTTFANTQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANA--- 246
Cdd:cd17325 161 LLALVL---ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPaqi 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 247 GIFLTIQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFvyISAIFIGITQALVYPTLTTYL 326
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKL--SDRIGRKPLILIGLLLSAVALLLLPLATSFWLLL--LLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488388729 327 SFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIF 383
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-352 |
8.30e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.12 E-value: 8.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 7 WPFLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMAL 86
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 87 VLYGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTIFAIV 165
Cdd:COG2814 90 LLCALaPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 166 MIFIAVTTTLFGYRTTFANTQKEVAPKEEVLPfnamtvyvQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVRE---G 242
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLR--------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlglS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 243 FANAGIFLTIQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFvyISAIFIGITQALVYPTL 322
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRL--ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLL--LALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|
gi 488388729 323 TTYLSFVLPKIGRNMLLGLFIACADLGISL 352
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-383 |
2.61e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.54 E-value: 2.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 TG-LEGYLVARIMQGV-CTAFFSMSLQLgIIDALPEKYRSEGVSLYSLFSTIPNLLGPLI--AVGIWHVENMTIFAIVMI 167
Cdd:cd17474 84 SDsFALLLAGRALQGIgAAGLGPLALTL-IGDLFEGGERAKAMGLYEAALGLGIAVGPLLggLLAAISWRYPFFLLAALI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 168 FIAVTTTLFgyrttfanTQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAG 247
Cdd:cd17474 163 PVAFLAILF--------LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 248 ----IFLTIQAITVVIARFYLRKYVPSDGlwHHRFMMIVLTLLMIASIIVAFGPQILSIFvyISAIFIGITQALVYPTLT 323
Cdd:cd17474 235 iiglLFAGWSVLLALGSLFVGRLLKKRFG--ARRILVIGLLLYALSLLLLGFVPSLALLL--IAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 324 TYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIF 383
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-353 |
4.58e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 75.53 E-value: 4.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 17 LMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGFT-GLE 95
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAsSLW 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 96 GYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIwhVENMTIFAIVMIFIAVTTTL 175
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--ASLFGWRAAFLILAILSLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 176 FGYRTTFANTQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFAN--AGIFLTIQ 253
Cdd:pfam07690 165 AVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAllAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 254 AITVVIARFYLRKYVPSDGLWhHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYLSFVLPKI 333
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRR-RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
330 340
....*....|....*....|
gi 488388729 334 GRNMLLGLFIACADLGISLG 353
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALG 343
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-383 |
1.44e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 74.13 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 T-GLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIaVGIWHVENMTIFAIVMIFIA 170
Cdd:cd17477 81 TdSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 171 VTTTLfgyrttFANTQKEVAPKEEVLPFNAMTVYvqffknKALFCSGMIMILSSIVFGAMSTFIPLYTVREGF--ANAGI 248
Cdd:cd17477 160 LALVP------LLLTRRAAPEIEEAESISLRRLL------RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLsvAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 249 FLTIQAITVVIARFYLRKYvpSDGLwHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYLSF 328
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWL--ADRF-DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488388729 329 VLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIF 383
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-384 |
1.73e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.39 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 -TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI--WHVENMTIFAIVMIF 168
Cdd:cd06174 81 aPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 169 IAVTTTLFGYRTTFANTQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGF---AN 245
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlsvAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 246 AGIFLTIQAITVVIARFYLRKYVpsdGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTY 325
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLS---DRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 326 LSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISD-TIGFKWMYILCALLVTIAMIFS 384
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-384 |
1.08e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.81 E-value: 1.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 10 LRLYILTLMFFS---ANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMAL 86
Cdd:COG0738 8 RALIAIYLLFFLwgfATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 87 VLYGFTG-LEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFS---TIPNLLGPLIAVGIWHVENMTIF 162
Cdd:COG0738 88 LLFALAPsYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSlgaLLGPLLGGLLILLGLSLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 163 AIVMIFIAVTTTLFgYRTTFANTQKEVAPKEEVLpfnamTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREG 242
Cdd:COG0738 168 LILAVLLLLLALLF-LRSKLPEIEEEEEEAAGSA-----ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 243 ---FANAGIFLTIQAITVVIARF---YLRKYVPSdglwhHRFMMIVLTLLMIASIIVAFGPQIlsIFVYISAIFIGITQA 316
Cdd:COG0738 242 glsEATAALGLSLFWGGMTIGRFlggFLLKRFGP-----VRLLRLSALLAAVGLLLALLAPGP--WLALIGLALVGLGLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488388729 317 LVYPTLTTYLSFVLPKIGRNMlLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAA-VSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-384 |
2.03e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.11 E-value: 2.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 9 FLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVL------RIILLIN 82
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladllRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 83 AMALVLYGFTGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIA---VGIWHVENM 159
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGgllVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 160 TIFAIVMIFIAVTTTLFGYRTTfantQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTV 239
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPP----PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 240 REGFANA---GIFLTIQAITVVIARFYLRKYVPSDGlwHHRFMMIVLTLLMIASIIVAFGPQIlsIFVYISAIFIGITQA 316
Cdd:cd06173 237 EVLGGGAagyGLLLAAFGVGALLGALLLGRLSKRRR--RGRLLLIGALLLGLALLVLGLSPSL--WLLLAALFLLGLAGG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488388729 317 LVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:cd06173 313 LFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
3-388 |
2.51e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 70.72 E-value: 2.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 3 GAMSWPFLRLYILTLMFFSAnailnvfiplrghdleatnTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLIN 82
Cdd:cd17329 15 FFMVWPFMAIYLHQQLGLSA-------------------SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 83 AMALVLYGFT-GLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGiwhvenMTI 161
Cdd:cd17329 76 ALGFALLGFAhSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL------LLL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 162 FAIVMIFIAVTTTLFGYRTTFANTQKEVAPKEEVLPFNAMTV-YVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVR 240
Cdd:cd17329 150 YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRgYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 241 EGFANA---GIFLTIQAITVVIARFYLRKYVpsdGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVyISAIFIGITQAL 317
Cdd:cd17329 230 ILGLGEsllGLLLALNALLIVLLQFPVARLV---ERFRLRKILMIGILLFAIGFAVLAFANTLAVLI-LAMIVLTLGEML 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488388729 318 VYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFSKIRQ 388
Cdd:cd17329 306 VFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-384 |
5.06e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.72 E-value: 5.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLR---GHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVL 88
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLpdiARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 89 YGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI-----WHVeNMTIF 162
Cdd:cd17324 81 AALaPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgqllgWRA-AFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 163 AIVMIFIAVTTTLFgyrttfantqKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREG 242
Cdd:cd17324 160 AVLALLAALLLWRL----------LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 243 F---ANAGIFLTIQAITVVIARFYLRKYVPsdgLWHHRFMMIVLTLLMIASIIVAFGPQILsIFVYISAIFIGITQALVY 319
Cdd:cd17324 230 GfssSAIIGLLLLFGVAGVVGSPLAGRLAD---RGGRRALLIALLLLAAALLLLTLLGPSP-LLLLVGLVLWGLGFFAAH 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488388729 320 PTLTTYLSFVLPKiGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:cd17324 306 SALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-384 |
7.04e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.97 E-value: 7.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 -TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI-----WHVeNMTIFAIV 165
Cdd:COG2271 95 aTSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlaafgWRA-AFLILGLP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 166 MIFIAVTTTLFGYrttfantqkevapkeevlpfnamtvyvqffknkalfcsgMIMILSSIVFGAMSTFIPLYTVRE---G 242
Cdd:COG2271 174 GLLLALLRFWLLA---------------------------------------LAYFLVYFALYGFLTWLPTYLVEVrglS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 243 FANAGIFLTIQAITVVIARF---YLrkyvpSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVY 319
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLlggWL-----SDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488388729 320 PTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
12-386 |
4.10e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 60.70 E-value: 4.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRII--LLINAMALVLY 89
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIglLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 90 GFTGLEGYLVARIMQGVCTAFFsMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTIFAIVMIFI 169
Cdd:cd17490 81 LFPSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 170 AVTTTLFGYRTtfantqKEVAPKEEVLPFNAMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANA--- 246
Cdd:cd17490 160 GVLGFILSLFI------KEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFqlg 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 247 ---GIFLTIQAITVVIARFYLRKYvpsdgLWHHRFMMIVLTLLMIASIIVAFGPQIlsIFVYISAIFIGITQALVYPTLT 323
Cdd:cd17490 234 llsIIYLLPNALASLLSGTLFYKK-----LGERNTIIIGFLLLGAYCFLIPFAPNL--TLLYLLQALNGFGTGILFPLLM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488388729 324 TYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFSKI 386
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
12-384 |
1.03e-08 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 56.43 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIP---LRGH---DLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMA 85
Cdd:PRK05122 15 LRIVSIVMFTFISYLTIGLPlavLPGYvhdQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 86 LVLYGFTGLEG---------YLVARIMQGVCTAF-FSMSLQLGIIDALPE---KYRS-EGVSLYSLFStipnlLGPLIAV 151
Cdd:PRK05122 95 GLLYLLAGLLAawpvlslllLLLGRLLLGIGESLaGTGSILWGIGRVGALhtgRVISwNGIATYGALA-----IGAPLGV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 152 GIWHVENMTIFAIVMIFIAVTTTLFGYRttfantQKEVAP-KEEVLPFnaMTVYVQFFKnkalfcSGMIMILSSIVFGAM 230
Cdd:PRK05122 170 LLYHWGGLAGLGLLIMLLALLGLLLARP------RPAVPPvKGERLPF--RRVLGRVWP------YGMGLALASIGFGTI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 231 STFIPLYTVREGFANAGIFLTIQAITVVIARFYLRKYVPSDGlwHHRFMMIVLTLLMIASIIVAFGPqiLSIFVYISAIF 310
Cdd:PRK05122 236 ATFITLYYAARGWDGAALALTLFGVAFVGARLLFGNLINRLG--GLRVAIVSLLVEILGLLLLWLAP--SPWMALIGAAL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488388729 311 IGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:PRK05122 312 TGFGFSLVFPALGVEAVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALT 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
33-386 |
1.63e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 55.66 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 33 RGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGFTG-LEGYLVARIMQGVCTAFF 111
Cdd:cd17330 25 EFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRnLWLLFLARFLDGLTGGNV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 112 SMSLQLgIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTIFAIVMIFIAVTTTLFGYRttfantqkevap 191
Cdd:cd17330 105 SVAQAY-IADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 192 keeVLPFnamtvyvqffknkaLFCSGMIMILSSIVFGAMSTFIPLYTVRE---GFANAGIFLTIQAITVVIAR-FYLRKY 267
Cdd:cd17330 172 ---FLPP--------------LRRLLLVYFLIALAFAGLESVFSLFLKDRfgfSPSQIGLLLALVGIAGILAQlLLIPRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 268 VPSDGLWhhRFMMIVLTLLMIASIIVAFGPQIlsIFVYISAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACAD 347
Cdd:cd17330 235 AKRLGER--KLLRLGLLLAIIGLLLLPFASSV--PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQS 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 488388729 348 LGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFSKI 386
Cdd:cd17330 311 LARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
32-384 |
3.42e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.89 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 32 LRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGLEGYLVARIMQGVCTAF 110
Cdd:cd17473 25 IAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFlDSLYALLASRALLGIGVAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 111 FsMSLQLGII-DALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI----WHvenmTIFAI--VMIFIAVTTTLFGYRTTFA 183
Cdd:cd17473 105 I-MTLATALIgDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALaeigWR----APFLVylLALPVLILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 184 NTQKEVAPKEEVLPFnamtvyvqffKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANA---GIFLTIQAITVVIA 260
Cdd:cd17473 180 SKSAASPGAATAAAL----------PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAaliGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 261 RFYLRKYVpsDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVyiSAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLG 340
Cdd:cd17473 250 ALLFGRLK--RRLGKRRLLAIGFALMALGFLLLALASGLWVVLL--GAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488388729 341 LFIACADLGISLGGVLMGPISDTIG-----FKWMYILCALLVTIAMIFS 384
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGPLVNLTGglsgaFLILGVLALVLAIVLLLLR 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-384 |
3.90e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.89 E-value: 3.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 17 LMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGLE 95
Cdd:COG2223 15 FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALaVSYW 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 96 GYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTI-FAIVMIFIAVTTT 174
Cdd:COG2223 95 LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNaFLILGILLLVVAV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 175 LFGYRTTFANTQKEVAPKEEVLPFNAMtvyvqfFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVRE---GFANAGIFLT 251
Cdd:COG2223 175 LAWLFLRDPPAGAAAAAKASLRDQLEA------LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfglSAATAGLLAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 252 IQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVyISAIFIGITQALVYPTLTTYLSFVLP 331
Cdd:COG2223 249 LFALLGALGRPLGGWL--SDRIGGRRVLLIVFALMALGLLLLALALGSLWLFL-VLFLLLGLALGGGNGAVFALVPDIFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488388729 332 KIGRNMLLGLFIACADLGISLGGVLMGPISDTIG-FKWMYILCALLVTIAMIFS 384
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLT 379
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-360 |
7.64e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 16 TLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGL 94
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALaPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 95 EGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIavGIWHVENMT---IFaIVMIFIAV 171
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL--GGLLLELFGwrwIF-LINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 172 TTTLFGYRTTFANtqkevapkeevlpfnamtvyvqffknkalfcsgMIMILSSIVFGAMSTFIPLY-TVREGF--ANAGI 248
Cdd:cd17321 162 VALLLARTFSGAV---------------------------------LAAFLLGAALGGLLFLLPLYlQGVLGYspLQAGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 249 FLTIQAITVVIARFYLRKYVPSdglWHHRFMMIV-LTLLMIASIIVAFGPQILS-IFVYISAIFIGITQALVYPTLTTYL 326
Cdd:cd17321 209 ALLPLALAMLVAAPLAGRLADR---FGPRLVLVAgLLLTAVGLLLLALLGADSSvWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330 340 350
....*....|....*....|....*....|....
gi 488388729 327 SFVLPKIGRNMLLGLFIACADLGISLGGVLMGPI 360
Cdd:cd17321 286 LSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-384 |
4.82e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 4.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 23 NAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGLEGYLVAR 101
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFaPNYWLLLLLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 102 IMQGVCTAFFSmSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI---WHVENMTIFAIVMiFIAVTTTLFGY 178
Cdd:cd17478 92 ALAGIGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALvalFGGLGLLILLIIP-GLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 179 RTTFANTQKEVAPKEEVLPfnamtvyVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGF--ANAGIFLTIQAIT 256
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARS-------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYslVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 257 VVIArfylrkyVPSDGLWHHRFMmivLTLLMIASIIVAFGPQILSIFV--YISAIFIGITQALVYPTLTTYLSFV--LPK 332
Cdd:cd17478 243 GAIG-------TLIGGPLSDRFG---RRRVIIASLLLAAPFLLLFLLTpgIWSYILLVLAGFLLFASFPVTVVLAqeLLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 488388729 333 IGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-382 |
6.51e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.05 E-value: 6.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 19 FFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLInAMALVLYGFTGLEGYL 98
Cdd:cd17335 9 FFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLL-AAVLFFLSLFFVAQIF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 99 VARIMQGVCTAFFSmSLQLGIIDALPEKYRSEGVSLYS---LFSTIPNLLGPL---IAVGIWHVENMTIFAIVMIFIAVT 172
Cdd:cd17335 88 WLLLLLVILGAFFS-APVVPLVDSITLQYLGEERERYGkqrLWGSIGFGIAALlvgILIDRSSTYKNYTIAFYVFAVLML 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 173 TTLFgYRTTFANTQKEVAPKEEVLPFnamtvyvqffknKALFCSGMIMILSSIVF------GAMSTFIPLYTVREGFANA 246
Cdd:cd17335 167 LALL-LALKFPFRPKHPEPNENTGGL------------LALLRNPRVLAFLLVAFlmgfghGLIYSFLFWHLQDLGGSKT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 247 --GIFLTIQAITVVIARFYLRKYVpsdGLWHHR-FMMIVLTLLMIASIIVAFGPQILsiFVYISAIFIGITQALVYPTLT 323
Cdd:cd17335 234 liGLLWTVGVVSEIPFFFFSSRLI---QRFGHVgLLYLGLLAYVVRWLLYSFLENPW--LVLPIELLHGLTFALVWAAAV 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 324 TYLSFVLPKIGRNMLLGLFIA-CADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMI 382
Cdd:cd17335 309 SYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLL 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
28-383 |
7.22e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 7.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 28 VFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGFT-GLEGYLVARIMQGV 106
Cdd:COG2807 39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLApSVALLLAGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 107 CTAFFSMSLqLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI-----WHvenmTIFAIVMIFIAVTTTLFGYRTT 181
Cdd:COG2807 119 GIAVGNVLL-PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLaaalgWR----GALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 182 FANTQKEVAPKEEVLpfnamtvyVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGF--ANAGIFLTIQAITVVI 259
Cdd:COG2807 194 RRPAAAAAAPAAASL--------RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLsaATAGLLLSLFQLAGIP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 260 ARFylrkYVP--SDGLWHHRFMMIVLTLLMIASII-VAFGPQILSifvYISAIFIGITQALVYPTLTTYLSFVLPKIGRN 336
Cdd:COG2807 266 GSL----LVPllADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLRARTPAEA 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488388729 337 -MLLGLFIACADLGISLGGVLMGPISD-TIGFKWMYILCALLVTIAMIF 383
Cdd:COG2807 339 aALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLMLVA 387
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
30-389 |
1.05e-06 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 50.44 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 30 IPLR-GHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMA---------LVLYGFTGLEGYLV 99
Cdd:PRK12382 38 IPLFvHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAglayllaaiLPVSAPFKFALLVV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 100 ARIMQGVCTAFF---SMSLQLGIIDalpeKYRS------EGVSLYSLFStipnlLGPLIAVGIWHVENMTIFAIVMIFIA 170
Cdd:PRK12382 118 GRLILGFGESQLltgALTWGLGLVG----PKHSgkvmswNGMAMYGALA-----AGAPLGLLLHSHFGFAALALTTMVLP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 171 VTTTLFGYRTtfantqKEVAP-KEEVLPFNAMTvyvqffknKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIF 249
Cdd:PRK12382 189 LLAWAFNGTV------RKVPAhAGERPSLWSVV--------GLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 250 LTIQAITVVIARFyLRKYVPsDGLWHHRFMMIVLTLLMIASIIVAFGPQilSIFVYISAIFIGITQALVYPTLTTYLSFV 329
Cdd:PRK12382 255 LTAFGGAFVLMRV-LFGWMP-DRFGGVKVAIVSLLVETVGLLLLWLAPT--AWVALAGAALTGAGCSLIFPALGVEVVKR 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488388729 330 LPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALL--VTIAMIFSKIRQG 389
Cdd:PRK12382 331 VPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISavLGIIVTILSFRRG 392
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
38-384 |
2.09e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 38 EATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGLEGYLVARIMQG---VCTAFFSM 113
Cdd:cd17472 28 GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYaTSIYGLILGRALQGsgaISSVVMAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 114 slqlgIIDALPEKYRSEGVSLYSLFS----TIPNLLGPLIAvGIWHVENMTIFAIVMIFIAVTTTLFgyrttfantqkeV 189
Cdd:cd17472 108 -----LADLTREENRTKAMALIGASIgiafAISMVLGPLLA-AHLGVSGLFLITAILSLVSLLILLF------------F 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 190 APKEEVLPFNAMTVYVQFF---KNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIFLT------IQAITVVIA 260
Cdd:cd17472 170 VPDPPKIVQISEKEKKKLKkllKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVylpailIGFILMVPF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 261 RFYLRKYvpsdglwHHRFMMIVLTLLMIASIIVAFGPQILS-IFVYISAIFIGITQALVYPTLTTYLSFVLPKIGRNMLL 339
Cdd:cd17472 250 VIYAEKK-------GKMKQVFVSSILLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAM 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488388729 340 GLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFS 384
Cdd:cd17472 323 GIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVS 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-383 |
2.30e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 22 ANAILNVFIplrgHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRII--LLINAMALVLYGFTGLEGYLV 99
Cdd:cd17370 18 ARSILPLFL----VVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILgyGLSALAKPLLALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 100 ARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI--WHVENMT---IFAIVMIFIAVTTT 174
Cdd:cd17370 94 LRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRtifLLAAIPALLALLIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 175 LFGYRTTfantQKEVAPKEEVLPFNAMTVYVQFFKnkalfcsgMIMILSSIVFGAMSTFIPLYTVREGFANA-------G 247
Cdd:cd17370 174 LFVVKEY----PRPPKLRKKSKKTSLKKLPKAFWL--------YLLAVALFALGNFSFAFLILRAQELGLSAalipllyA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 248 IFLTIQAITVVIA-RFYLRKyvpsdglwhHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYL 326
Cdd:cd17370 242 LFNLVYALAAYPAgRLSDRI---------GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488388729 327 SFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIF 383
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
42-366 |
6.02e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 42 TVIGIVMGAYMLTAMLFRPWAGQIIARVGP-----IKVLRIILLINAMALVLYGFTGLEGYLVARIMQGVCTAFFSMSLQ 116
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSDRTRTrwgrrRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 117 LGII--DALP------EKYRSEGVSLYSLFSTIPNLLGPLIA---VGIWHVENMTIFAIVMIFIAVTTTLFGYrTTFANT 185
Cdd:COG2211 126 LVNIpySALGaeltpdYEERTRLSSWRFAFAGLGGLLASVLPpplVAAFGGDAALGYRLTALIFAVLGLLAFL-LTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 186 QKEVAPKEEVLPFNAMtvYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYT---VREGFANAGIFLTIQAITVVIArf 262
Cdd:COG2211 205 KERPVPEEEKVSLKES--LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFkyvLGLSAALVGLLLALYFLAALLG-- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 263 ylrkyVPSDGLWHHRF-----MMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYLSFVLP----KI 333
Cdd:COG2211 281 -----APLWPRLAKRFgkkkaFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewKT 355
|
330 340 350
....*....|....*....|....*....|....*.
gi 488388729 334 GRN---MLLGLFIACADLGISLGGVLMGPISDTIGF 366
Cdd:COG2211 356 GRRregLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-384 |
6.26e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 6.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 208 FKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGF--ANAGIFLTIQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTL 285
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAspAQAGLVVTAYLLGAALGAPLAGRL--ADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 286 LMIASIIVAFGPQILSIFvyISAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIG 365
Cdd:COG2814 85 FALGSLLCALAPSLWLLL--AARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170
....*....|....*....
gi 488388729 366 FKWMYILCALLVTIAMIFS 384
Cdd:COG2814 163 WRWVFLVNAVLALLALLLL 181
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
161-366 |
7.20e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.60 E-value: 7.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 161 IFAIVMIFIAVTTTLFGYRTTFANTQKEVAPKEEVLPfnaMTVYVQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVR 240
Cdd:cd17332 174 LTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL---LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKY 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 241 ------EGFANAGIFLTIQAITVVIARFYLRKYVPsdglwhHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGIT 314
Cdd:cd17332 251 vlggraELVLLLLLILSGALLALLPWPPLKKRFGK------KKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIG 324
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 488388729 315 QALVYPTLTTYLSFVL----PKIGRN---MLLGLFIACADLGISLGGVLMGPISDTIGF 366
Cdd:cd17332 325 YGGANLLPWAMLADVIdygeLKTGKRregIFYSVMTFFRKLGLALAGALVGLILSLAGY 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-176 |
2.01e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 4 AMSWPFLRLYILTLMFFSAnailnvfiplrghdleatnTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINA 83
Cdd:cd17325 216 GALEPFLPLYAAELGGLSP-------------------AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 84 MALVLYGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENM-TI 161
Cdd:cd17325 277 VALLLLPLaTSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFaTP 356
|
170
....*....|....*
gi 488388729 162 FAIVMIFIAVTTTLF 176
Cdd:cd17325 357 FLAAAALLLLAAVLF 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
12-383 |
3.77e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.39 E-value: 3.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF 91
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 92 TGLEGYLVARI-MQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMTIFAIVMIFIA 170
Cdd:cd17333 81 TPSIYLFVVLMfLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 171 VTTTLFGYRTTFANTQKEVAPKEEVLPFNAMTVyvQFFKNKALFCSGMIMILSSIVFGAMSTFIPLYTVREGFAN---AG 247
Cdd:cd17333 161 LLLAILILLTLFPELPSARNPQQSVGAFSASAS--RLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSdglAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 248 IFLTIQAITVVIARFYLRkyVPSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGItqALVYPTLTTYLS 327
Cdd:cd17333 239 YLLSGFWVGITIGRLLGG--PISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM--AALFPTILSLGI 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488388729 328 FVLPKIGRNmLLGLFIACADLGISLGGVLMGPISDTIG---FKWMYILCALLVTIAMIF 383
Cdd:cd17333 315 SNLPYAKGK-GTSVLLAAGSIGGAIIPFIMGFIAEAVGiqtAMLLITILYAIIFVLALL 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-156 |
4.68e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.80 E-value: 4.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 7 WPFLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMAL 86
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488388729 87 VLYGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHV 156
Cdd:COG0477 94 LLCGLaPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-150 |
5.06e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 8 PFLRLYILTLMFFSANAILNVFIPLRGHD-LEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMAL 86
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488388729 87 VLYGFTGLEGYLVARIMQGVCTAFFSM------SLQLGIIDA--LPEKYRSEGV--SLYSLFSTIPNLLGPLIA 150
Cdd:COG2211 309 LLLFFLGPGNLWLLLVLAALAGIGLGAilvlpwAMLADVVDYdeWKTGRRREGLyfGIFTFAIKLGQALAGALA 382
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
8-386 |
6.47e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 6.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 8 PFLRLYILTLMFFSANAIlnvfiplrghdleatNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALV 87
Cdd:cd17391 17 PFLPLYIEQLGVTSGGLV---------------ELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 88 LYGF-TGLEGYLVARIMQGVCTAFFSMSLQLgIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIA---VGIWHVENMTIFA 163
Cdd:cd17391 82 LMAFvTNVWQLLILRLLQGVFSGYVPNATAL-IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGgflADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 164 IVMIFIAVTTTLFGYRTTFantqKEVAPKEEVLpfnaMTVYVQFFKNKALFCSgMIMILSSIVFGAMST--FIPLYtVRE 241
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDF----KPVEKKKMVS----TKEVWNSVPNPSLLIS-LFVTTFIIQLANQSIepILTLY-IRQ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 242 GFAN-------AGIFLTIQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYisAIFIGIT 314
Cdd:cd17391 231 LMGDasnlafiSGLVFSATGVSSLLSAPRLGKL--GDRIGHHRILLGALLASALLYIPQAFVQTPWQLGIL--RFLLGLA 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488388729 315 QALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYILCALLVTIAMIFSKI 386
Cdd:cd17391 307 TGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-150 |
1.83e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSANAILNVFIPL-RGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYG 90
Cdd:cd17504 186 ALLAGFGMFMVFQLLPQLLQLpTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488388729 91 F--TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIA 150
Cdd:cd17504 266 LlhSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-153 |
3.08e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.56 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 11 RLYILTLMFFSA------NAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAM 84
Cdd:cd17319 1 RWRIIPLLFLAYvinyldRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 85 ALVLYGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGPLIAVGI 153
Cdd:cd17319 81 FTALTGFaTSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL 150
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
212-383 |
3.35e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 212 ALFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIFL--TIQAITVVIARFYLRKYVPSDGlwhHRFMMIVLTLLM-I 288
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLlfAIPVLVGALLRIPLGFLVDRFG---PRRVLLIGLLLLgI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 289 ASIIVAFGPQILSIFVYisAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKW 368
Cdd:COG2223 83 GLLLLALAVSYWLLLLL--GLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170
....*....|....*
gi 488388729 369 MYILCALLVTIAMIF 383
Cdd:COG2223 161 AFLILGILLLVVAVL 175
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
6-109 |
3.79e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.19 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 6 SWPFLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMA 85
Cdd:cd17335 197 NPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVR 276
|
90 100
....*....|....*....|....*
gi 488388729 86 LVLYGFTGLEGY-LVARIMQGVCTA 109
Cdd:cd17335 277 WLLYSFLENPWLvLPIELLHGLTFA 301
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
12-382 |
4.57e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLMFFSAN---AILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARV--------------GPIKV 74
Cdd:cd17313 1 LFLLGFGFFGIEfgwALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCnsrigrrrpfilvgAPLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 75 LRIILLINAMALVLYGFTGLEGYLVARIMQGVCTAFFSMSLQLG-----IIDALPEKYRSEGVSLYSLFSTIPNLLGPLI 149
Cdd:cd17313 81 LGLILIPNAADIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGpvralLPDLVPPEQRSKANGIINFMGGLGGVLGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 150 AVGIW-----------HVENMTIFAIVMIFIAVTTTLFGYR-TTFANTQKEVAPKEEVLPFNAMTVYVQFFKNKALFCSG 217
Cdd:cd17313 161 GAILWdhnwfgfalggNLKVPFYIGAIILLVCVLVTLFFVKePPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 218 MIMILSSIVFGAMSTFIPLYTVREGFAN--------------AGIFLTIQAITVVIARFYLRKYVPSdglWHHRFM-MIV 282
Cdd:cd17313 241 LVIFFWWIAFFPFELFFTDYMGEEVYHGtsaasshygagvrmGAWGLLIFSLAFLIFSLPIGKLGKK---IGRKKVyLIG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 283 LTLLMIASIIVAFGPQILSIFVyiSAIFIGITQALVYPTLTTYLSFVLPKIGRNMllGLFIACADLGISL----GGVLMG 358
Cdd:cd17313 318 LVLFAVGMALMALVHNVTVALV--LFALGGIGWATININPYPLVSDYHSESGRGQ--GTDTGLLNLAISLaqilVSLLAG 393
|
410 420
....*....|....*....|....
gi 488388729 359 PISDTIGFKWMYILCALLVTIAMI 382
Cdd:cd17313 394 PIIDVKGYGTVFPVAAVASFLSLV 417
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
213-383 |
8.39e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 8.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 213 LFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIFLTIQAITVVIARFYLRKYvpSDGLWHHRFMMIVLTLLMIASII 292
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL--SDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 293 VAFGPQILsiFVYISAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLMGPISDTIGFKWMYIL 372
Cdd:pfam07690 79 LLFASSLW--LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|.
gi 488388729 373 CALLVTIAMIF 383
Cdd:pfam07690 157 LAILSLLAAVL 167
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
12-149 |
1.21e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 40.67 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 12 LYILTLM-FFSANAILNVFiPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYG 90
Cdd:cd17390 1 LYLVGFLdLFGVSMILPLL-STHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488388729 91 F-TGLEGYLVARIMQGVctafFSMSLQLG---IIDALPEKYRSEGVSLYSLFSTIPNLLGPLI 149
Cdd:cd17390 80 FsTSLALLFLSRIPLGI----FKHTQSLCkayLSDLVSEQERSRVLGRFNAASSLGFILGPVV 138
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-382 |
1.29e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 20 FSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGFTG--LEGY 97
Cdd:cd17355 16 WGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATslWQLY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 98 LVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLG-PLIAVGIWHV---ENMTIFAIVMIFIAVTT 173
Cdd:cd17355 96 LLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFlPLGAALIEAFgwrTALLVLALLALLVLVPV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 174 TLFGYRTTFANTQKEVAPKEEVLPFNAMTvyvQFFKNKA--LFCSGMIMILSSIVFGAMSTFIPLYTVREGFANAGIFLT 251
Cdd:cd17355 176 LLLLRRRPADLALRAYDDASPASPGSTLK---EALRSASfwLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 252 IQAITVVIARfylRKYVPSDGLWHHRFMMIVLTLLMIASIIVAFGPQILSIFVYISAIFIGITQ-ALVYPTLTTYLSFVL 330
Cdd:cd17355 253 LIGLFNIVGR---LLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWgATVPLTAALAARYFG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488388729 331 PKIGrNMLLGLFIACADLGISLGGVLMGPISDTIG-FKWMYILCALLVTIAMI 382
Cdd:cd17355 330 ARSY-GTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-147 |
1.48e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 8 PFLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALV 87
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488388729 88 LYGFTGL----EGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRSEGVSLYSLFSTIPNLLGP 147
Cdd:pfam07690 281 GLLLLSLtlssLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
275-383 |
2.40e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.55 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 275 HHRFMMIVLTLLMIASIIVAFGPQilSIFVYISAIFIGITQALVYPTLTTYLSFVLPK-IGRNMLLGLFIACADLGISLG 353
Cdd:cd17476 62 HKKMFVIGSFWFAIWSLIAGFSPN--FIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALG 139
|
90 100 110
....*....|....*....|....*....|....
gi 488388729 354 GVLMGPISDTIGFKWMY----ILCALLVTIAMIF 383
Cdd:cd17476 140 GVFGGLFAQLAWWPWIFwflaILAAIVAVAAIFW 173
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
51-382 |
3.59e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.10 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 51 YMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALVLYGF-TGLEGYLVARIMQGVCTAFFSMSLQLGIIDALPEKYRS 129
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFsPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 130 EGVSLYSLFSTIPNLLGPLIAVGIWHvenmtifaivMIFIAVTTTLFGYrttfantqkevapkeevlpfnaMTVYVQFFK 209
Cdd:cd17317 114 FVGILFGLFWALGYMLLALLAYLIRD----------WRWLQLAISLPGL----------------------LFLLLLWWL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 210 NKALFCSGMIMILSSIVFGAMSTFIPLYTVREgFANAGIFLTIQAITVVIARFYLRKYvpsdglWHHRFMMIVLTLLMIA 289
Cdd:cd17317 162 PRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNL-YLNFFLSGLVEIPAYFLALLLLDRL------GRRWTLSGSLLLAGLA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 290 SIIVAFGPQILSIFVYISAIFIGITQALVYPTLTTYLSFVLPKIGRNMLLGLFIACADLGISLGGVLmgPISDTIGFKWM 369
Cdd:cd17317 235 CLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFI--VLLGKIGPLLP 312
|
330
....*....|...
gi 488388729 370 YILCALLVTIAMI 382
Cdd:cd17317 313 LIIFGVLALLGGL 325
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
8-171 |
3.93e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 8 PFLRLYILTLMFFSANAILNVFIPLRGHDLEATNTVIGIVMGAYMLTAMLFRPWAGQIIARVGPIKVLRIILLINAMALV 87
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488388729 88 LYGFTGLEGYLVArimqGVCTAFFSMSLQLGIIDAL-----PEKYRSEGVSLYSLFSTIPNLLGPLIAVGIWHVENMT-- 160
Cdd:cd17370 280 GFALGSSLWLLLL----GFILWGLYMGAQESIERAAvadlvPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSaa 355
|
170
....*....|..
gi 488388729 161 -IFAIVMIFIAV 171
Cdd:cd17370 356 fLFSAVLALIAL 367
|
|
| |
