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Conserved domains on  [gi|488398611|ref|WP_002467996|]
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MULTISPECIES: two-component system regulatory protein YycI [Staphylococcus]

Protein Classification

two-component system regulatory protein YycI( domain architecture ID 10008884)

two-component system regulatory protein YycI is a membrane-anchored periplasmic protein that, together with YycH, regulates the activity of the two-component system WalR/WalK (also called YycFG), which regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance, and antibiotic resistance

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-255 1.95e-65

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


:

Pssm-ID: 443881  Cd Length: 259  Bit Score: 204.39  E-value: 1.95e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611   1 MNWKLTKTLFIFVFILVNIFLVIVYIDKVNKSQVNDS--EKVNEVNFQQEEIDVPKDVlnqSVKDTELEQITARSKNFSS 78
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSSlsETTIEERLKADNITLKTDL---PKETPPGSYLSAKFKDFTE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  79 yaKDHSSLQ----TSDSDKTLEGDIDKGVQVSDKN-LQDIKEYIAKKIFNGKEYQLSDLTKDK--VTYEQTYKDYPIMNN 151
Cdd:COG4853   78 --AELEQLKgqkvKISDNTKLYSTLKEPIKISDKDdLEDLEDFVKSNVLFGKEYQYWKYDSDGntIVFFQTYDGRPIYYN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611 152 SKARLTFNLSD-GKATSYKQTAMDDIQVakgsNSTKKQVITPRKAIEALYYNRYLKQNDQVLDARLGYYSVVKETNVQLL 230
Cdd:COG4853  156 QNAQLTFYLNDdNEITSYTQTYLDDIEE----LGEKKDLISAIKAIETLYENNELPSNSTITDIKLGYYSLVQLSDTQVL 231
                        250       260
                 ....*....|....*....|....*
gi 488398611 231 QPNWEIKVKHkgKDEVQTYYVEATN 255
Cdd:COG4853  232 APTWRITVEN--EDGTEIYFVNAIT 254
 
Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-255 1.95e-65

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


Pssm-ID: 443881  Cd Length: 259  Bit Score: 204.39  E-value: 1.95e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611   1 MNWKLTKTLFIFVFILVNIFLVIVYIDKVNKSQVNDS--EKVNEVNFQQEEIDVPKDVlnqSVKDTELEQITARSKNFSS 78
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSSlsETTIEERLKADNITLKTDL---PKETPPGSYLSAKFKDFTE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  79 yaKDHSSLQ----TSDSDKTLEGDIDKGVQVSDKN-LQDIKEYIAKKIFNGKEYQLSDLTKDK--VTYEQTYKDYPIMNN 151
Cdd:COG4853   78 --AELEQLKgqkvKISDNTKLYSTLKEPIKISDKDdLEDLEDFVKSNVLFGKEYQYWKYDSDGntIVFFQTYDGRPIYYN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611 152 SKARLTFNLSD-GKATSYKQTAMDDIQVakgsNSTKKQVITPRKAIEALYYNRYLKQNDQVLDARLGYYSVVKETNVQLL 230
Cdd:COG4853  156 QNAQLTFYLNDdNEITSYTQTYLDDIEE----LGEKKDLISAIKAIETLYENNELPSNSTITDIKLGYYSLVQLSDTQVL 231
                        250       260
                 ....*....|....*....|....*
gi 488398611 231 QPNWEIKVKHkgKDEVQTYYVEATN 255
Cdd:COG4853  232 APTWRITVEN--EDGTEIYFVNAIT 254
YycI pfam09648
YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram ...
32-254 1.17e-46

YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.


Pssm-ID: 430732  Cd Length: 231  Bit Score: 155.58  E-value: 1.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611   32 SQVNDSEKVN---EVNFQQEEIDVPKDVLNQSVKDtelEQITARSKNFSSyaKDHSSL------QTSDSDKTLEGDIDKG 102
Cdd:pfam09648   2 NQSNISSSTTtdiEKELKADNITYPCDLPKEKGKG---YYLSAKQKDFSL--KEVLDKlkgqtvTTSNDTKTLTSTFDKP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  103 VQVS-DKNLQDIKEYIA--KKIFNGKEYQLSDL--TKDKVTYEQTYKDYPIMNNsKARLTFNLS-DGKATSYKQTAMDDI 176
Cdd:pfam09648  77 IKISkDDNLKDLNDFLNdkKNVLKGKDYQYWKElsSKKTIVYFQKYKGKPIYDN-DAQLVFYLNnDNEITSYTQTYLEDI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  177 QVAKgsnsTKKQVITPRKAIEALYYNRYLKQNDQVLDARLGYYSVV--KETNVQLLQPNWEIKVKHKGKDEVQTYYVEAT 254
Cdd:pfam09648 156 KELR----EKKELISARRAIETLYTNNELKNNSKVTWIKLGYYSLLqqTVRSKQVYVPTWRITIENKSSKEVQIYFVNAF 231
 
Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-255 1.95e-65

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


Pssm-ID: 443881  Cd Length: 259  Bit Score: 204.39  E-value: 1.95e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611   1 MNWKLTKTLFIFVFILVNIFLVIVYIDKVNKSQVNDS--EKVNEVNFQQEEIDVPKDVlnqSVKDTELEQITARSKNFSS 78
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSSlsETTIEERLKADNITLKTDL---PKETPPGSYLSAKFKDFTE 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  79 yaKDHSSLQ----TSDSDKTLEGDIDKGVQVSDKN-LQDIKEYIAKKIFNGKEYQLSDLTKDK--VTYEQTYKDYPIMNN 151
Cdd:COG4853   78 --AELEQLKgqkvKISDNTKLYSTLKEPIKISDKDdLEDLEDFVKSNVLFGKEYQYWKYDSDGntIVFFQTYDGRPIYYN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611 152 SKARLTFNLSD-GKATSYKQTAMDDIQVakgsNSTKKQVITPRKAIEALYYNRYLKQNDQVLDARLGYYSVVKETNVQLL 230
Cdd:COG4853  156 QNAQLTFYLNDdNEITSYTQTYLDDIEE----LGEKKDLISAIKAIETLYENNELPSNSTITDIKLGYYSLVQLSDTQVL 231
                        250       260
                 ....*....|....*....|....*
gi 488398611 231 QPNWEIKVKHkgKDEVQTYYVEATN 255
Cdd:COG4853  232 APTWRITVEN--EDGTEIYFVNAIT 254
YycI pfam09648
YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram ...
32-254 1.17e-46

YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.


Pssm-ID: 430732  Cd Length: 231  Bit Score: 155.58  E-value: 1.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611   32 SQVNDSEKVN---EVNFQQEEIDVPKDVLNQSVKDtelEQITARSKNFSSyaKDHSSL------QTSDSDKTLEGDIDKG 102
Cdd:pfam09648   2 NQSNISSSTTtdiEKELKADNITYPCDLPKEKGKG---YYLSAKQKDFSL--KEVLDKlkgqtvTTSNDTKTLTSTFDKP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  103 VQVS-DKNLQDIKEYIA--KKIFNGKEYQLSDL--TKDKVTYEQTYKDYPIMNNsKARLTFNLS-DGKATSYKQTAMDDI 176
Cdd:pfam09648  77 IKISkDDNLKDLNDFLNdkKNVLKGKDYQYWKElsSKKTIVYFQKYKGKPIYDN-DAQLVFYLNnDNEITSYTQTYLEDI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611  177 QVAKgsnsTKKQVITPRKAIEALYYNRYLKQNDQVLDARLGYYSVV--KETNVQLLQPNWEIKVKHKGKDEVQTYYVEAT 254
Cdd:pfam09648 156 KELR----EKKELISARRAIETLYTNNELKNNSKVTWIKLGYYSLLqqTVRSKQVYVPTWRITIENKSSKEVQIYFVNAF 231
YycH COG4863
YycH protein, regulator of the WalKR two-component signal transduction system [Signal ...
125-239 1.33e-05

YycH protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


Pssm-ID: 443891 [Multi-domain]  Cd Length: 442  Bit Score: 45.78  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488398611 125 KEYQLS--DLTKDKVTYEQTYKDYPIMNN-SKARLTFNLSDGKATSYkQTAMDDIQVAKGSNSTKKQVITPRKAIEALYY 201
Cdd:COG4863  305 DDYRLFgiDASGYTVTFRLYVNGLPVFSDdGMSDISVTWGNGDVYEY-KRPLYSLDVPIPSEKEEVTLPSGEEVIEALEK 383
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488398611 202 NRYLKQNDqVLDARLGYYSVVKETNVQL--LQPNWEIKVK 239
Cdd:COG4863  384 NAGYDLNK-IDDIEIGYELTKDEENDQVvdLEPTWYVKYN 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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