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Conserved domains on  [gi|488399445|ref|WP_002468830|]
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MULTISPECIES: halocin C8 precursor-like protein [Staphylococcus]

Protein Classification

halocin_C8_dom family protein( domain architecture ID 10025228)

halocin_C8_dom family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
halocin_of_epi NF040679
halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) ...
 18-244 4.10e-115

halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) homologs of the archaeal bacteriocin halocin C8 precursor. Members average about 245 amino acids in length, with the 76 amino acid Cys-rich mature peptide region at the C-terminus. Cutoff scores are set fairly high because this HMM is designed to identify full-length members of the family such as WP_002493350.1 from Staphylococcus epidermidis.


:

Pssm-ID: 468644  Cd Length: 243  Bit Score: 329.51  E-value: 4.10e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  18 CVATGFQNVNAANNE---VSKPQSNVDSKTKQNIIKKIKKSNAYKKHANSTSIDSIKDDDIIVHLDKGKNTNVYSINYVF 94
Cdd:NF040679  17 CVPSIFASVEAALNEntlVEKPTSNVSSKTKQKIINKVKKSDAYKNHAKSTSINSIKDDNIIVHLDKGDNTNVYSVNFIF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  95 GKKLAKMNDNLAMIELKYNEANNEVFYNHMMYSKFVKYNNkeyINMKGILNGKPYYEFNIDQKGHYYDKNFKHTSKDEIE 174
Cdd:NF040679  97 GKELAKQNDNLAMVEFKYNEANKEVFYDHMMFSKFVDDDN---INMKGVLNGKPYYEFNIDPEGVYYDLNFKETSKEEIE 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445 175 KDSAKNLPPEERGWCEWAVGALCGTGGAAGCWATATALGITTGWGGFSLATICGLISSLGCTGATNYICK 244
Cdd:NF040679 174 DNSQKNIPPKERSWCEWAVGALCGTGGAGGCYAAAGALGITTGWGGLGLAAICALILSLGCTGATNYICK 243
 
Name Accession Description Interval E-value
halocin_of_epi NF040679
halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) ...
 18-244 4.10e-115

halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) homologs of the archaeal bacteriocin halocin C8 precursor. Members average about 245 amino acids in length, with the 76 amino acid Cys-rich mature peptide region at the C-terminus. Cutoff scores are set fairly high because this HMM is designed to identify full-length members of the family such as WP_002493350.1 from Staphylococcus epidermidis.


Pssm-ID: 468644  Cd Length: 243  Bit Score: 329.51  E-value: 4.10e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  18 CVATGFQNVNAANNE---VSKPQSNVDSKTKQNIIKKIKKSNAYKKHANSTSIDSIKDDDIIVHLDKGKNTNVYSINYVF 94
Cdd:NF040679  17 CVPSIFASVEAALNEntlVEKPTSNVSSKTKQKIINKVKKSDAYKNHAKSTSINSIKDDNIIVHLDKGDNTNVYSVNFIF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  95 GKKLAKMNDNLAMIELKYNEANNEVFYNHMMYSKFVKYNNkeyINMKGILNGKPYYEFNIDQKGHYYDKNFKHTSKDEIE 174
Cdd:NF040679  97 GKELAKQNDNLAMVEFKYNEANKEVFYDHMMFSKFVDDDN---INMKGVLNGKPYYEFNIDPEGVYYDLNFKETSKEEIE 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445 175 KDSAKNLPPEERGWCEWAVGALCGTGGAAGCWATATALGITTGWGGFSLATICGLISSLGCTGATNYICK 244
Cdd:NF040679 174 DNSQKNIPPKERSWCEWAVGALCGTGGAGGCYAAAGALGITTGWGGLGLAAICALILSLGCTGATNYICK 243
halocin_C8_dom TIGR04449
halocin C8-like bacteriocin domain; This model describes the 76-amino C-terminal domain of the ...
 189-244 1.49e-11

halocin C8-like bacteriocin domain; This model describes the 76-amino C-terminal domain of the halocin C8 precursor that actually becomes the mature bacteriocin halocin C8 after export and cleavage, as well as homologous C-terminal regions from many other archaea. Surprisingly, this Cys-rich region occurs also in many strains of Staphylococcus epidermidis. Gene regions do not provide evidence for post-translational modification other than cleavage. Halocin C8 is active against a broad range of archaea; the region N-terminal to the bacteriocin domain modeled here serves as the immunity protein for the cell secreting the bacteriocin. [Cellular processes, Toxin production and resistance]


Pssm-ID: 275242  Cd Length: 69  Bit Score: 58.22  E-value: 1.49e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488399445  189 CEWAVGALCGTGGAAGCWATATALGITT-GWGGFSL----ATICGLISSLGCTGATNYICK 244
Cdd:TIGR04449   4 CTTAVGLLCRLGCGAGCAAICGLLGLATfGIGGLACagfcAAVCWLISGYGCGAAARYICG 64
 
Name Accession Description Interval E-value
halocin_of_epi NF040679
halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) ...
 18-244 4.10e-115

halocin C8 precursor-like protein; Members of this family are bacterial (mostly staphylococcal) homologs of the archaeal bacteriocin halocin C8 precursor. Members average about 245 amino acids in length, with the 76 amino acid Cys-rich mature peptide region at the C-terminus. Cutoff scores are set fairly high because this HMM is designed to identify full-length members of the family such as WP_002493350.1 from Staphylococcus epidermidis.


Pssm-ID: 468644  Cd Length: 243  Bit Score: 329.51  E-value: 4.10e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  18 CVATGFQNVNAANNE---VSKPQSNVDSKTKQNIIKKIKKSNAYKKHANSTSIDSIKDDDIIVHLDKGKNTNVYSINYVF 94
Cdd:NF040679  17 CVPSIFASVEAALNEntlVEKPTSNVSSKTKQKIINKVKKSDAYKNHAKSTSINSIKDDNIIVHLDKGDNTNVYSVNFIF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445  95 GKKLAKMNDNLAMIELKYNEANNEVFYNHMMYSKFVKYNNkeyINMKGILNGKPYYEFNIDQKGHYYDKNFKHTSKDEIE 174
Cdd:NF040679  97 GKELAKQNDNLAMVEFKYNEANKEVFYDHMMFSKFVDDDN---INMKGVLNGKPYYEFNIDPEGVYYDLNFKETSKEEIE 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488399445 175 KDSAKNLPPEERGWCEWAVGALCGTGGAAGCWATATALGITTGWGGFSLATICGLISSLGCTGATNYICK 244
Cdd:NF040679 174 DNSQKNIPPKERSWCEWAVGALCGTGGAGGCYAAAGALGITTGWGGLGLAAICALILSLGCTGATNYICK 243
halocin_C8_dom TIGR04449
halocin C8-like bacteriocin domain; This model describes the 76-amino C-terminal domain of the ...
 189-244 1.49e-11

halocin C8-like bacteriocin domain; This model describes the 76-amino C-terminal domain of the halocin C8 precursor that actually becomes the mature bacteriocin halocin C8 after export and cleavage, as well as homologous C-terminal regions from many other archaea. Surprisingly, this Cys-rich region occurs also in many strains of Staphylococcus epidermidis. Gene regions do not provide evidence for post-translational modification other than cleavage. Halocin C8 is active against a broad range of archaea; the region N-terminal to the bacteriocin domain modeled here serves as the immunity protein for the cell secreting the bacteriocin. [Cellular processes, Toxin production and resistance]


Pssm-ID: 275242  Cd Length: 69  Bit Score: 58.22  E-value: 1.49e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488399445  189 CEWAVGALCGTGGAAGCWATATALGITT-GWGGFSL----ATICGLISSLGCTGATNYICK 244
Cdd:TIGR04449   4 CTTAVGLLCRLGCGAGCAAICGLLGLATfGIGGLACagfcAAVCWLISGYGCGAAARYICG 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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