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Conserved domains on  [gi|488409703|ref|WP_002479088|]
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MULTISPECIES: alpha/beta hydrolase [Staphylococcus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10006645)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
14-181 4.39e-44

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


:

Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 148.21  E-value: 4.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  14 EITIQLPKDYGKQKvKRYAALIVHDGDMLFK----------RCNKDM---IFIGI----LSKERTKDFTPWPAKVGTR-- 74
Cdd:COG2819   22 RIRVYLPPGYDAPE-KRYPVLYMLDGQNLFDalagavgtlsRLEGGIppaIVVGIgngdDGERRLRDYTPPPAPGYPGpg 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  75 LNQGQASRYLTWLTTQLLPYVREQYRVSLNNQdiGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWY--PEFIDFMKQ 152
Cdd:COG2819  101 GPGGGADAFLRFLEEELKPYIDKRYRTDPERT--GLIGHSLGGLFSLYALLKYPDLFGRYIAISPSLWWddGALLDEAEA 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 488409703 153 -QQAINASVHVYWYVGMKEGIKHTQIVKDM 181
Cdd:COG2819  179 lLKRSPLPKRLYLSVGTLEGDSMDGMVDDA 208
 
Name Accession Description Interval E-value
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
14-181 4.39e-44

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 148.21  E-value: 4.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  14 EITIQLPKDYGKQKvKRYAALIVHDGDMLFK----------RCNKDM---IFIGI----LSKERTKDFTPWPAKVGTR-- 74
Cdd:COG2819   22 RIRVYLPPGYDAPE-KRYPVLYMLDGQNLFDalagavgtlsRLEGGIppaIVVGIgngdDGERRLRDYTPPPAPGYPGpg 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  75 LNQGQASRYLTWLTTQLLPYVREQYRVSLNNQdiGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWY--PEFIDFMKQ 152
Cdd:COG2819  101 GPGGGADAFLRFLEEELKPYIDKRYRTDPERT--GLIGHSLGGLFSLYALLKYPDLFGRYIAISPSLWWddGALLDEAEA 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 488409703 153 -QQAINASVHVYWYVGMKEGIKHTQIVKDM 181
Cdd:COG2819  179 lLKRSPLPKRLYLSVGTLEGDSMDGMVDDA 208
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
1-213 2.18e-09

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 55.93  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703    1 MNKRRQVFqmdgfeitIQLPKDYGKQKvkRYAALIVHDGDMLF--------------KRCNKDMIFIGILSKERTKDFTP 66
Cdd:pfam00756   4 LGREMKVQ--------VYLPEDYPPGR--KYPVLYLLDGTGWFqngpakegldrlaaSGEIPPVIIVGSPRGGEVSFYSD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703   67 WPakVGTRLNQG-QASRYLTWLTTQLLPYVREQYRVslNNQDIGIAGASYGGLVSLYALYTMPQQFG------KYILISP 139
Cdd:pfam00756  74 WD--RGLNATEGpGAYAYETFLTQELPPLLDANFPT--APDGRALAGQSMGGLGALYLALKYPDLFGsvssfsPILNPSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  140 SVWYPEF---------IDFMKQQQAINASVHVYWYVGMKEgikhtqivkdmvgnSLLGKAILANDLANET--STFKFQTA 208
Cdd:pfam00756 150 SMWGPEDdpawqegdpVLLAVALSANNTRLRIYLDVGTRE--------------DFLGDQLPVEILEELApnRELAEQLA 215

                  ....*
gi 488409703  209 KRGIH 213
Cdd:pfam00756 216 YRGVG 220
PRK10439 PRK10439
enterobactin/ferric enterobactin esterase; Provisional
86-144 8.28e-07

enterobactin/ferric enterobactin esterase; Provisional


Pssm-ID: 236695 [Multi-domain]  Cd Length: 411  Bit Score: 48.86  E-value: 8.28e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409703  86 WLTTQ--LLPYVREQYRVSLNNQDIGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWYP 144
Cdd:PRK10439 266 WLAVQqeLLPQVRAIAPFSDDADRTVVAGQSFGGLAALYAGLHWPERFGCVLSQSGSFWWP 326
 
Name Accession Description Interval E-value
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
14-181 4.39e-44

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 148.21  E-value: 4.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  14 EITIQLPKDYGKQKvKRYAALIVHDGDMLFK----------RCNKDM---IFIGI----LSKERTKDFTPWPAKVGTR-- 74
Cdd:COG2819   22 RIRVYLPPGYDAPE-KRYPVLYMLDGQNLFDalagavgtlsRLEGGIppaIVVGIgngdDGERRLRDYTPPPAPGYPGpg 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  75 LNQGQASRYLTWLTTQLLPYVREQYRVSLNNQdiGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWY--PEFIDFMKQ 152
Cdd:COG2819  101 GPGGGADAFLRFLEEELKPYIDKRYRTDPERT--GLIGHSLGGLFSLYALLKYPDLFGRYIAISPSLWWddGALLDEAEA 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 488409703 153 -QQAINASVHVYWYVGMKEGIKHTQIVKDM 181
Cdd:COG2819  179 lLKRSPLPKRLYLSVGTLEGDSMDGMVDDA 208
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
14-172 5.89e-19

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 83.36  E-value: 5.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  14 EITIQLPKDYGKQKvKRYAALIVHDG-----DMLFKRCN--------------KDMIFIGilskertkdftPWPAKVGTR 74
Cdd:COG2382   96 RVWVYLPPGYDNPG-KKYPVLYLLDGgggdeQDWFDQGRlptildnliaagkiPPMIVVM-----------PDGGDGGDR 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  75 LNQGQAS-RYLTWLTTQLLPYVREQYRVSLNNQDIGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWYPEF------- 146
Cdd:COG2382  164 GTEGPGNdAFERFLAEELIPFVEKNYRVSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSGSFWWPPGdadrggw 243
                        170       180
                 ....*....|....*....|....*.
gi 488409703 147 IDFMKqQQAINASVHVYWYVGMKEGI 172
Cdd:COG2382  244 AELLA-AGAPKKPLRFYLDVGTEDDL 268
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
1-213 2.18e-09

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 55.93  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703    1 MNKRRQVFqmdgfeitIQLPKDYGKQKvkRYAALIVHDGDMLF--------------KRCNKDMIFIGILSKERTKDFTP 66
Cdd:pfam00756   4 LGREMKVQ--------VYLPEDYPPGR--KYPVLYLLDGTGWFqngpakegldrlaaSGEIPPVIIVGSPRGGEVSFYSD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703   67 WPakVGTRLNQG-QASRYLTWLTTQLLPYVREQYRVslNNQDIGIAGASYGGLVSLYALYTMPQQFG------KYILISP 139
Cdd:pfam00756  74 WD--RGLNATEGpGAYAYETFLTQELPPLLDANFPT--APDGRALAGQSMGGLGALYLALKYPDLFGsvssfsPILNPSN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409703  140 SVWYPEF---------IDFMKQQQAINASVHVYWYVGMKEgikhtqivkdmvgnSLLGKAILANDLANET--STFKFQTA 208
Cdd:pfam00756 150 SMWGPEDdpawqegdpVLLAVALSANNTRLRIYLDVGTRE--------------DFLGDQLPVEILEELApnRELAEQLA 215

                  ....*
gi 488409703  209 KRGIH 213
Cdd:pfam00756 216 YRGVG 220
PRK10439 PRK10439
enterobactin/ferric enterobactin esterase; Provisional
86-144 8.28e-07

enterobactin/ferric enterobactin esterase; Provisional


Pssm-ID: 236695 [Multi-domain]  Cd Length: 411  Bit Score: 48.86  E-value: 8.28e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409703  86 WLTTQ--LLPYVREQYRVSLNNQDIGIAGASYGGLVSLYALYTMPQQFGKYILISPSVWYP 144
Cdd:PRK10439 266 WLAVQqeLLPQVRAIAPFSDDADRTVVAGQSFGGLAALYAGLHWPERFGCVLSQSGSFWWP 326
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
94-139 9.44e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 36.15  E-value: 9.44e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488409703  94 YVREQYRVSLNNqdIGIAGASYGGLVSLYALYTMPQQFGKYILISP 139
Cdd:COG1506   83 YLAARPYVDPDR--IGIYGHSYGGYMALLAAARHPDRFKAAVALAG 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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