|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-439 |
3.56e-37 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 139.27 E-value: 3.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 27 LFMILGTIFLDAYDITILGTMTDQLTQQF--HLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 105 LGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRV 184
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 185 AVGFGAIIALVLYLLRlkflhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygKRLL 264
Cdd:cd17316 161 LFLIGALPALLALLLR------------------------------------------------------------RRTL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 265 LATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGtRKLTIIGFALVLIAMVMT 344
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 345 GVFYHLLPMILNTFLIALFLFGHSGGPGTQGKTIgALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTML 424
Cdd:cd17316 260 LFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL-AELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
410
....*....|....*
gi 488409712 425 ILSIVPLVGLIITSA 439
Cdd:cd17316 339 LILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-403 |
3.23e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 136.26 E-value: 3.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 21 YTSKMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLAL 100
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 101 VITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTGSh 180
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPL--LGGLLADLFG- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 181 lWRVAVGFGAIIALVLYLLRLKFLHESPTwminhyslgqaadyirqkyhvdiqlasnqtndvssQERQPSARALFQPKYG 260
Cdd:COG2814 163 -WRWVFLVNAVLALLALLLLLRLLPESRP-----------------------------------AARARLRGSLRELLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 261 KRLLLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIA 340
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488409712 341 MVMTGVFYHLLPMILNTFLIALFLFGhsGGPGTQgkTIGALSFPTYLRSQATGFVEAVSRTGS 403
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGL--LFPLLQ--ALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
36-438 |
1.21e-34 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 133.20 E-value: 1.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 36 LDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTI 115
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 116 LLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALV 195
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 196 LYLLRLkFLHESPTWminhyslgQAADYIRQkyhvdiqlasnqtndvsSQERQPSARALFQPKYGKRLLLATAISTLQGM 275
Cdd:cd17371 170 VLFIRR-FVKEPPQW--------QAARAARR-----------------HFADRPSLRELFSPPLLRTTLLASLLATGALG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 276 QYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTgVFYHLLPMIL 355
Cdd:cd17371 224 GYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLY-FFLPLSPTLI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 356 nTFLIALFLFGHSGGPGTQGkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLI 435
Cdd:cd17371 303 -LILGFPLGFFASGPFSGMG-AYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGL 380
|
...
gi 488409712 436 ITS 438
Cdd:cd17371 381 VLA 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-443 |
1.09e-32 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 126.91 E-value: 1.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 105 LGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGshlWRV 184
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP-LLGWLLAAFG---WRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 185 AVGFGAIIALVLYLLrlkflhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygkRLL 264
Cdd:COG2271 166 AFLILGLPGLLLALL--------------------------------------------------------------RFW 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 265 LATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALvLIAMVMT 344
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL-LLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 345 GVFYHLLPMILNTFLIALFLFGHSGGPGTQGkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTML 424
Cdd:COG2271 263 LLLALLPSPALAIALLFLAGFGLGGAFGLLW-ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
410
....*....|....*....
gi 488409712 425 ILSIVPLVGLIITSAIKWE 443
Cdd:COG2271 342 LLAALALLAALLALLLLRE 360
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
35-437 |
2.99e-32 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 126.24 E-value: 2.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQF-----HLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL 109
Cdd:cd17364 9 FTDAYDLFSISLVTKILGRLYyggkgSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 110 SPN------LTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSH--- 180
Cdd:cd17364 89 SPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLpag 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 181 -------LWRVAVGFGAIIALVLYLLRLKFLHESPTWMInhyslgqaadyirqkyhVDIQLASNqtndvssqerqpsarA 253
Cdd:cd17364 169 tyhhadlVWRIVLGLGAIPALSVLYFRKHLLGTAGTWFL-----------------LDIAFYGQ---------------N 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 254 LFQPKYGKRLLLATAISTLQGMQYYAVGLYIpiiatyiiskeklgvllgtaIVNIAGIVGAYFGAQLTYRLGTRKLTIIG 333
Cdd:cd17364 217 LFQSTIISAIGFSKTMNAYQELFNIAVGQLI--------------------IALAGTVPGYWFTVFLIDRIGRKKIQMMG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 334 FALVLIAMVMTGVFYHLLPMILNTFLI--ALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFP 411
Cdd:cd17364 277 FFGMTIFLLILAGPYDHWKISTIGFFVlyGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFL 356
|
410 420
....*....|....*....|....*.
gi 488409712 412 IILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17364 357 SLTQNIGVRNVLIILAGVALLGIILT 382
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
35-436 |
6.42e-32 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 125.37 E-value: 6.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLT 114
Cdd:cd17359 11 LLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 115 ILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQvvwyVAIVTSSLC--VIAFFLMGTGSHL------WRVAV 186
Cdd:cd17359 91 IFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQ----LMIVFGQLLayIVNYLIANAGGADwlgaegWRWML 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 187 GFGAIIALVLYLLRLkFLHESPTWMInhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpKYGKRLLLA 266
Cdd:cd17359 167 GLEAIPAILFLLGML-FIPESPRWLV---------------------------------------------SKGKPILII 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 267 ----TAISTLQGMQyyAVGLYIPIIATYIISKEKlGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMV 342
Cdd:cd17359 201 giglAIFQQFVGIN--VIFYYGPEIFQNAGFSEN-AALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 343 MTGVFYHLLPMILNTFLIALFL-------FGHSGGPGTQgKTIGALsFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILA 415
Cdd:cd17359 278 LIGTAFYFAPGSQASGIVALVLillfvafFAMSWGPVTW-VLLSEI-FPNRIRGLAMGIAVFFLWIANFLVSLTFPILLA 355
|
410 420
....*....|....*....|.
gi 488409712 416 AVGLTNTMLILSIVPLVGLII 436
Cdd:cd17359 356 AFGLAFTFLIFAVICVLAFLF 376
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
35-437 |
7.07e-32 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 126.62 E-value: 7.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQF------HLSPTMLSTVMTSL-----PIGALIGAIFGGVFAHRFGRKRILSISLLALVIT 103
Cdd:pfam00083 10 FLFGYDTGVIGAFLTLIDFFKnfglskSVSSLAALSVLSGLivsifSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 104 SLGAALSP---NLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSlCVIAFFLMGTGSH 180
Cdd:pfam00083 90 AVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY-IFGLGLNKTSNSD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 181 LWRVAVGFGAIIALVLYLLRLkFLHESPTWMINHYSLGQAADYIRQKYHVDIQLASNQ----TNDVSSQERQPSARALFQ 256
Cdd:pfam00083 169 GWRIPLGLQLVPALLLIIGLL-FLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDeikdSLEAGQEAEKASWKELFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 257 PKyGKRLLLATAIStLQGMQYYAVGLYIPIIATYIisKEKLGV---LLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIG 333
Cdd:pfam00083 248 TK-TRRQRLLIGVM-LQIFQQLTGINAIFYYSTTI--FENLGLsdsFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 334 FALVLIAMVMTGVFYHLLPM------ILNTFLIALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGT 407
Cdd:pfam00083 324 AAGMAICFVILGIVALLGVSksdwagIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIG 403
|
410 420 430
....*....|....*....|....*....|
gi 488409712 408 FIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:pfam00083 404 FLFPIITDAIGLGYTFFIFAGLLVLFIIFV 433
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-406 |
1.37e-30 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 122.08 E-value: 1.37e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 34 IFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNL 113
Cdd:TIGR00895 26 MLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 114 TILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTgsHLWRVAVGFGAIIA 193
Cdd:TIGR00895 106 TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGF--LAGWLIPV--FGWRSLFYVGGIAP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 194 LVLYLLRLKFLHESPTWMINhyslgQAADYIRQKYH-VDIQLASNQTNDVSSQERQP-----SARALFQPKYGKRLLLAT 267
Cdd:TIGR00895 182 LLLLLLLMRFLPESIDFLVS-----KRPETVRRIVNaIAPQMQAEAQSALPEQKSTQgtkrsVFKALFQGKTARITVLLW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 268 AISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGtAIVNIAGIVGAYFGAQLTYRLGTRkltIIGFALVLIAMVMTGVF 347
Cdd:TIGR00895 257 LLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGG-ALFNFGGVIGSIIFGWLADRLGPR---VTALLLLLGAVFAVLVG 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 348 YHLlpMILNTFLIALFLFG-HSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIG 406
Cdd:TIGR00895 333 STL--FSPTLLLLLGAIAGfFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIG 390
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
23-203 |
2.74e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 104.89 E-value: 2.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 23 SKMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVI 102
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 103 TSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTGShlW 182
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL--LGGLLVAALG--W 167
|
170 180
....*....|....*....|.
gi 488409712 183 RVAVGFGAIIALVLYLLRLKF 203
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
35-437 |
3.29e-25 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 106.12 E-value: 3.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQFH--LSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPN 112
Cdd:cd17315 7 LLFGYDLGVINGALLYIAKDLGfgLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 113 LTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLmgTGSHLWRVAVGFGAII 192
Cdd:cd17315 87 VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSL--SPPGWWRLMFALAAVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 193 ALVLYLLRLkFLHESptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygKRLLLATAISTL 272
Cdd:cd17315 165 ALLQLLLMF-FLPES-----------------------------------------------------RALLVGVGLQLL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 273 Q------GMQYYavglyipiiATYIISK--EKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMT 344
Cdd:cd17315 191 QqltginAVMYY---------APTIFKSagGGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 345 GVFYHLLPM-----ILNTFLIALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGL 419
Cdd:cd17315 262 AIAFLLPALakaagWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGL 341
|
410
....*....|....*...
gi 488409712 420 TNTMLILSIVPLVGLIIT 437
Cdd:cd17315 342 AGVFIFFAAVCLLALVFV 359
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
47-437 |
1.88e-23 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 101.88 E-value: 1.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 47 MTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMA 126
Cdd:cd17358 28 LMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 127 IGMDSPVAFTFIAEISNRAQKGRNVnywqVVWYVAIVTSSLcvIAFFLmgtGSHL-WRVAVGFGAIIaLVLYLLRLKFLH 205
Cdd:cd17358 108 GGAASVVVPVYIAEIAPKNVRGALG----SLNQLLVNIGIL--LGYVL---GSFLpWRTLALIGAIP-PVVFLILLFFIP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 206 ESPTW--MINHYS-LGQAADYIRQKYHVDIQLASNQTNDVSSQERQPSA---RALFQPKYGKRLLLATAISTLQ------ 273
Cdd:cd17358 178 ESPRWlaKKGREEeAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKEssfSDLFQRKYLKPLVIGLGLMLFQqlsgin 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 274 GMQYYAVGLYipiiatyiiskEKLGVLL----GTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYH 349
Cdd:cd17358 258 AVIFYASSIF-----------DEAGSGLdpntATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFY 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 350 LLPM--------ILNTFLIALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTN 421
Cdd:cd17358 327 LQEHgallssvsWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASG 406
|
410
....*....|....*.
gi 488409712 422 TMLILSIVPLVGLIIT 437
Cdd:cd17358 407 TFWIFAGICGLALVFV 422
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
29-450 |
3.38e-23 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 102.11 E-value: 3.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 29 MILGT-IFLDAYDITILGTMTDQLTQQF-----HLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVI 102
Cdd:TIGR00887 19 VIAGVgFFTDSYDLFCISLVTKMLGYVYyhgkgPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 103 TSLGAALSPNLTIL----LLC--RFLMGMAIGMDSPVAFTFIAEISNRAQKGR---NVNYWQ----------VVWYVAIV 163
Cdd:TIGR00887 99 ATVASGLSPGSSPKsvmaTLCfwRFWLGVGIGGDYPLSAIITSEFATKKWRGAmmaAVFAMQgfgilagaivALIVLAGF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 164 TSSLCVIAFFLMGTGS------HLWRVAVGFGAIIALVLYLLRLKfLHESPTWMINH-YSLGQAADYIRQKYHVDIQLAS 236
Cdd:TIGR00887 179 KHSLEAAADEASCTGScvpavdYMWRILIGFGAVPALLALYFRLT-IPETPRYTADVaKDVEQAASDMSAVLQVKIEAEP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 237 NQTNDVSSQERQPSA------RALFQPKYGKrLLLATAIS-TLQGMQYYAVGL----------YIPIIATYIISKEKLGV 299
Cdd:TIGR00887 258 DEVEKASTAVEVPKAswsdffTHFFKWRHGK-HLLGTAGSwFLLDIAFYGVNLnqkvilsaigYSPPAATNNAYEELYKT 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 300 LLGTAIVNIAGIV-GAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPM--ILNTFLIALFLFGHsgGPGTQGK 376
Cdd:TIGR00887 337 AVGNLIIALAGTVpGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSThgFLAIYVLAQFFANF--GPNATTF 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 377 TIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIIL----------AAVGLTNTMLILSIVPLVGLIITSAIKwEPVG 446
Cdd:TIGR00887 415 IVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAqhgdptkgypTGIWMGHVLEIFALFMFLGILFTLLIP-ETKG 493
|
....
gi 488409712 447 KNVE 450
Cdd:TIGR00887 494 KSLE 497
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-436 |
6.25e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.81 E-value: 6.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 30 ILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 110 SPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGShlWRVAVGFG 189
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG--WRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 190 AIIALVLYLLRLKFLHESPtwminhyslgqaadyirqkyhvdiQLASNQTNDVSSQERQPSARALFQPkygKRLLLATAI 269
Cdd:cd06174 159 AALALLAAILLLLVVPDPP------------------------ESARAKNEEASSKSVLKLLKRVLKN---PGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 270 STLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLT-YRLGTRKLTIIGFALVLIAMVMTGVFY 348
Cdd:cd06174 212 IFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 349 HLLPMILNTFLIALFLFGHSGGPGtqgkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSI 428
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGGLLPLSF----ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
....*...
gi 488409712 429 VPLVGLII 436
Cdd:cd06174 368 VLLLLAAI 375
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
63-432 |
1.40e-22 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 99.64 E-value: 1.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 63 STVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALS---PNLTILLLCRFLMGMAIGMDSPVAFTFIA 139
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 140 EISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAfFLMGTgSHLWRVAVGFGAIIALVLYLLrLKFLHESPTWMINHYSLGQ 219
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGLP-SVLGT-ETLWPYLLFFPGIPALLQLAA-LPFFPESPKFLLISKGDEE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 220 AADYIRQKYH-----VDIQLASNQTNDVSSQER-QPSARALFQ-PKYGKRLLLATAISTLQGMQ------YYAVGLYIPI 286
Cdd:cd17357 209 EAEKSLKFLRgieddVDQELEEIKKESEQMGDQkQVSLMQLLRdPSLRLPLLLVLVVSASQQFSginaifFYSTFIFENA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 287 IATYIISKEklgVLLGTAIVNIAGIVGAYFgaqLTYRLGTRKLTIIGFALVLIAMVMTGVF------YHLLPMILNTFLI 360
Cdd:cd17357 289 GFSPQLAEW---ANLGIGIVNVLSTIVGPF---LIEKVGRRPLLLISLSVCAVALLLMSVFlflseqNSWMSYGCIVAIF 362
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488409712 361 aLFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLtnTMLILSIVPLV 432
Cdd:cd17357 363 -LFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGG--FVFIIFAIPCA 431
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
20-450 |
1.54e-22 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 99.72 E-value: 1.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 20 QYTSKMLLFMILGTIFLDAYDITILGTMTDQLTQQF----HLSPTMLST----VMTSLPIGALIGAIFGGVFAHRFGRKR 91
Cdd:TIGR00879 23 YWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFkftsANSDSYSSSlwglVVSIFLVGGFIGALFAGWLSDRFGRKK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 92 ILSISLLALVITSLGAALSPNLT---ILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLC 168
Cdd:TIGR00879 103 SLLIIALLFVIGAILMGLAAFALsveMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 169 VIAFFLMGTgSHLWRVAVGFGAIIALVLYLLrLKFLHESPTWMINHYSLGQAADYIRQKYHVDIQLASNQTNDVSSQERQ 248
Cdd:TIGR00879 183 GSGKVSLNN-TLGWRIPLGLQLIPAGLLFLG-LFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLDELELIDIKR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 249 PSARALFQP------KYGKRLLL-ATAISTLQGMQYYAVGLYIPIIATYIIskEKLGV-----LLGTAIVNIAGIVGAYF 316
Cdd:TIGR00879 261 SIEKRSVQPswgslfSSTRRIRRrLFLGVVLQWFQQFTGINAIMYYSPTIF--ENAGVstdhaFLVSIIVGAVNFAFTFV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 317 GAQLTYRLGTRKLTIIGFALVLIAM-VMTGVFYHLLPM------ILNTFLIALFLFGHSGGPGTQGKTIGALSFPTYLRS 389
Cdd:TIGR00879 339 AIFLVDRFGRRPLLLIGAAGMAICLfVLGILGASFVTGsskssgNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRP 418
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409712 390 QATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIITSAIKWEPVGKNVE 450
Cdd:TIGR00879 419 KGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLE 479
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
71-437 |
2.11e-22 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 99.71 E-value: 2.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIV 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 151 VNYWQVVWYVAIVtsSLCVIAFFLMGtgshlWR---VAVGFGAIIALVLYLlrlkFLHESPTWMINHYSLGQAADYIRQ- 226
Cdd:TIGR00898 218 GTLIQVFFSLGLV--LLPLVAYFIPD-----WRwlqLAVSLPTFLFFLLSW----FVPESPRWLISQGRIEEALKILQRi 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 227 -----KYHVDIQLASNQTNDVSSQERQPSARALFQ-PKYGKRLLLATAISTLQGMQYYAVGLYIPII--ATYIIskeklg 298
Cdd:TIGR00898 287 akingKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRtPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLggNIYLD------ 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 299 vLLGTAIVNIAGIVGAYFgaqLTYRLGtRKLTIIGFALVLIAMVMTGVFYHLLPMILNTFLIALFLFGHSGGPGTQGKTI 378
Cdd:TIGR00898 361 -LFISGLVELPAKLITLL---LIDRLG-RRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYT 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488409712 379 GALsFPTYLRSQATGFVEAVSRTGSIIGTFIFpiILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:TIGR00898 436 AEL-YPTVVRNLGVGVCSTMARVGSIISPFLV--YLGEKWLFLPLVLFGGLALLAGILT 491
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-444 |
8.89e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.49 E-value: 8.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 27 LFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRnVNYWQVVWYVAIVTSSLCVIAFFLMGTGshlWRVAV 186
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGL-ALGLAAGGGNLGAAVAAFLAPLLIAAFG---WRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 187 GFGAIIALVLYLLRLKFLHESPtwminhyslgqaadyirqkyhvdiqlasnqtnDVSSQERQPSARALFQPKYGKRLLLA 266
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPP--------------------------------AGAAAAAKASLRDQLEALRDPRFWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 267 TAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMtgV 346
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL--L 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 347 FYHLLPMILNTFLIALFLFGHSGGPGTQGKTIGALsFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVG-LTNTMLI 425
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI-FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLV 367
|
410
....*....|....*....
gi 488409712 426 LSIVPLVGLIITSAIKWEP 444
Cdd:COG2223 368 FAVLALVALVLTLLLYRRP 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-441 |
2.56e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.95 E-value: 2.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 30 ILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL 109
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 110 SPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTS-SLCVIAFFLMGtgshlWRVAVGF 188
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGpLLGGLLADALG-----YRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 189 GAIIALVLYLLRLKFLHESPTwminhyslgqaadyirqkyhvdiqlaSNQTNDVSSQERQPSARALFQPkygKRLLLATA 268
Cdd:cd17325 156 CAALALLALVLALLLLPEPRP--------------------------PPNKRAVSAARLRSGLRLLLRD---RRLLALFL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 269 ISTLQGMQYYAVGLYIPIIAT--YIISKEKLGVLLGtaIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGV 346
Cdd:cd17325 207 AIFVLAFAFGALEPFLPLYAAelGGLSPAQIGLLFG--AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 347 FYHLLPMILNTFLIALFLfghsGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLIL 426
Cdd:cd17325 285 ATSFWLLLLLLALLGLGL----GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
410
....*....|....*
gi 488409712 427 SIVPLVGLIITSAIK 441
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
27-440 |
2.72e-20 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 91.88 E-value: 2.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 27 LFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTgsHLWRVAV 186
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGF--LAAALIPA--FGWRSVF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 187 GFGAIIALVLYLLRLKFLhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygkrLLLA 266
Cdd:cd17365 157 LLGGVPPLILLPLLRGTL----------------------------------------------------------LLWV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 267 TAISTLQGMqyYAVGLYIPII---ATYIISKeklgVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVM 343
Cdd:cd17365 179 TFFMGLLLV--YLLNSWLPKLmveAGYSLSQ----ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLAL 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 344 TGVFYHLLPMiLNTFLIALFLFGHSGGPGTQGKTigALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAA-VGLTNT 422
Cdd:cd17365 253 LGVSPASLVL-LYVLVFLAGACVNGAQVGLYALA--ARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAgLGPESV 329
|
410
....*....|....*...
gi 488409712 423 MLILSIVPLVGLIITSAI 440
Cdd:cd17365 330 FLALAIPAALGALAVLLL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-407 |
3.20e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 3.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 29 MILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAA 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 109 LSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFflmgTGSHLWRVAVGF 188
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL----ASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 189 GAIIALVLYLLRLKFLHESPTWminhyslgqaadyirqkyhvdiqlasnqtNDVSSQERQPSARALFQPKYGKRLLLATA 268
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESK-----------------------------RPKPAEEARLSLIVAWKALLRDPVLWLLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 269 ISTLQGMQYYAVGLYIPIIATYI-ISKEKLGVLLGtaIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVF 347
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLgLSALLAGLLLG--LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 348 YHLLPMILNTFLIALFLFGHSGGPGTQGkTIGALSFPTYLRSQATGFVEAVSRTGSIIGT 407
Cdd:pfam07690 286 SLTLSSLWLLLALLLLGFGFGLVFPALN-ALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-441 |
2.62e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 2.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 24 KMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVIT 103
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 104 SLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISnRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHLWR 183
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 184 VAVGFGAIIALVLYLLRLKFLHESptwminhyslgqaadyirqkyhvdiqlasnQTNDVSSQERQPSARALFQPkygKRL 263
Cdd:COG0738 166 PYLILAVLLLLLALLFLRSKLPEI------------------------------EEEEEEAAGSAASLKSLLKN---PRL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 264 LLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVM 343
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 344 TGVFYHLLPMILNTFLIALFLfghSGG-PGTQGKTIGALSFPTylrSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNT 422
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGL---SLMfPTIFSLALDGLGKRT---AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAA 366
|
410
....*....|....*....
gi 488409712 423 MLILSIVPLVGLIITSAIK 441
Cdd:COG0738 367 FLVPLVCYLLILLLALALK 385
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
64-435 |
3.26e-19 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 88.87 E-value: 3.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 64 TVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISN 143
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 144 RAQKGRnvnywQVVWYVAIVTSSLcVIAFFLMGTGSHL---WRVAVGFGAIIALVLYLLRLkFLHESPTWminhyslgqa 220
Cdd:cd17360 119 PRIRGR-----LVTINVLFITGGQ-FVAYVINGAFSYLpggWRWMLGLAAVPAVLQFIGLL-FLPESPRW---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 221 adyirqkyhvdiqlasnqtndvssqerQPSARALFqpkygkrlllatAISTLQGMQYYA----VGLYIPIIATYIISKEK 296
Cdd:cd17360 182 ---------------------------PSTRRALI------------VGCGLQAFQQFSgintVMYYSATILQMAGFKDN 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 297 LGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLpmilntfLIALFLFGHSGGPGTQGK 376
Cdd:cd17360 223 QNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLAVWLALV-------GLILYLAFFAPGMGPVPW 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488409712 377 TIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLI 435
Cdd:cd17360 296 TVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLI 354
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
41-440 |
3.92e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 85.70 E-value: 3.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 41 ITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCR 120
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 121 FLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLmgtGSHLWRVAVGFGAIIALVLYLLR 200
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPL--LGGLL---AAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 201 LKFLHESPTwminhyslgqaadyirqkyhvdiqlasnqtndvssQERQPSARALFQPK--YGKRLLLATAISTLQGM-QY 277
Cdd:cd17474 170 LFLLPEPKE-----------------------------------KAKSSSATKLRDLKkaLRGRGLLTFLVSAFLYFfLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 278 YAVGLYIPIIA--TYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLT-YRLGTRKLTIIGFALVLIAMVMTGVFYHLLpmi 354
Cdd:cd17474 215 FAFLTYLPFLLelLYGISPIIIGLLF--AGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALSLLLLGFVPSLA--- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 355 lnTFLIALFLFGHSGG---PGTQgkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPL 431
Cdd:cd17474 290 --LLLIAIVLFGLGLGlnlPLLT--TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIAL 365
|
....*....
gi 488409712 432 VGLIITSAI 440
Cdd:cd17474 366 AAAVLLALL 374
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
36-432 |
7.90e-18 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 85.01 E-value: 7.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 36 LDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTI 115
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 116 LLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNywqvVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALV 195
Cdd:PRK11551 106 LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVS----LMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 196 LYLLRLKFLHESPtwminhyslgqaaDYIRQKyhvdiqlasnqtndVSSQERQPSARALFQPkygkrlllATAISTLQgm 275
Cdd:PRK11551 182 LVPLLMRWLPESR-------------AFAQAA--------------GAGKQRAPVLRALFGE--------GRATATLL-- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 276 qyyavgLYIPIIATYII-----------------SKEKLGVLlgTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVL 338
Cdd:PRK11551 225 ------LWISYFFTLIVlyfllnwlpsllvgqglSRSQAGLV--QIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGIL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 339 IAMVMTGVFYHLLPMILNTFLIALFLFghsggpGTQGKTIG--ALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAA 416
Cdd:PRK11551 297 ASLAALAAAPSFAGMLLAGFAAGLFVV------GGQSVLYAlaPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLAL 370
|
410
....*....|....*.
gi 488409712 417 vGLTNTMLILSIVPLV 432
Cdd:PRK11551 371 -GRSTVGVIGASIPVI 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
47-437 |
7.93e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.52 E-value: 7.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 47 MTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMA 126
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 127 IGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSlcVIAFFLMGTGShlWRVAVGFGAIIALVLYLLRLKFLHE 206
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGR--PLGGLLGQLLG--WRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 207 SPtwminhyslgqaadyirqkyhvdiqlasnQTNDVSSQERQPSARALFQPKYGKRLLLATAISTLQGMQYYAVGLYipI 286
Cdd:cd17324 177 LP-----------------------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPF--L 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 287 IATYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPMILNTFLIALFLFg 366
Cdd:cd17324 226 TDVPGFSSSAIIGLL--LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF- 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409712 367 hSGGPGTQGKtigALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17324 303 -AAHSALQTR---VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
52-450 |
2.02e-16 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 80.47 E-value: 2.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 52 TQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDS 131
Cdd:cd17362 31 TDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 132 PVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVtssLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYlLRLKFLHESPTWm 211
Cdd:cd17362 111 HAAPVYIAETSPSHIRGLLVSLKELFIVLGIL---LGYVSGYAFADVVGGWRYMYGLAAPPALLLG-IGMWFLPPSPRW- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 212 inhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfQPKYGKRLLLATAISTLQGMQ-YYAVGLYIPIIAty 290
Cdd:cd17362 186 --------------------------------------------QGNYRKPLIIGLGLVLFQQITgQPSVLYYAATIF-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 291 iiskEKLGVLLGTAIVNIAGIVGAY------FGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPMILN----TFLI 360
Cdd:cd17362 220 ----KSAGFSAASDATLVSVGLGVFkllmtiVAVLLVDKLGRRPLLLGGVSGMVVSLFLLAAYNLFVQMGPAglawLSLV 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 361 ALFLF--GHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIITS 438
Cdd:cd17362 296 ALLLYvgAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIY 375
|
410
....*....|..
gi 488409712 439 AIKWEPVGKNVE 450
Cdd:cd17362 376 FTVPETKGLSLE 387
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-417 |
6.21e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.14 E-value: 6.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 30 ILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL 109
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 110 SPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIvtsslcVIAFFLMG--TGSHLWRVAVG 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGA------ALGPLLGGllLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 188 FGAIIALVLYLLrlkflhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkyGKRLLLAT 267
Cdd:cd17321 155 INVPIGLVALLL------------------------------------------------------------ARTFSGAV 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 268 AISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVF 347
Cdd:cd17321 175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALL 254
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409712 348 YHLLPMILntFLIALFLFGHSGGPGTQGKTIGALS-FPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAV 417
Cdd:cd17321 255 GADSSVWL--LLPGLVLLGLGLGLFATPLTNAALSsVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
41-440 |
2.20e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.61 E-value: 2.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 41 ITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCR 120
Cdd:COG2807 34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 121 FLMGMAIGMDSPVAFTFIAEISNRaqkgrnvnywQVVWYVAIVTSSLCVIAFFLMGTGSHL-----WRVAVGFGAIIALV 195
Cdd:COG2807 114 ALIGAGIAVGNVLLPGLIKRWFPD----------RVGLMTGLYTAAMGLGAALAAGLTVPLaaalgWRGALAVWALLALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 196 LYLLRLKFLHESPtwminhyslgqaadyirqkyhvdiqlasnqTNDVSSQERQPSARALFQPkygkRLLLATAISTLQGM 275
Cdd:COG2807 184 ALLLWLPLLRRRP------------------------------AAAAAAPAAASLRSLWRSP----LAWLLTLFFGLQSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 276 QYYAVGLYIPIIATYI-ISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTgvfyhLLPMI 354
Cdd:COG2807 230 LYYAVVAWLPPILRDAgLSAATAGLLL--SLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLG-----LLLAP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 355 LNTFLIALFLFGHSGGpgtqGKTIGALSFPTyLRS-------QATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILS 427
Cdd:COG2807 303 GSLPWLWAVLLGLGQG----GLFPLALTLIG-LRArtpaeaaALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLL 377
|
410
....*....|...
gi 488409712 428 IVPLVGLIITSAI 440
Cdd:COG2807 378 AALAVLMLVAGLL 390
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
28-418 |
8.00e-15 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 75.75 E-value: 8.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 28 FMILGTIFldAYDITILGTMTDQLTQQFH---------LSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLl 98
Cdd:cd17356 6 VSLGGFLF--GYDTGSISGILNMKSFQKYfadntgtyyPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGC- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 99 alVITSLGAALS----PNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAI-VTSSLCVIAFF 173
Cdd:cd17356 83 --VIYIIGAIIQvaaiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGIlVAYCINYGTHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 174 LMGTGShlWRVAVGFGAIIALVLyLLRLKFLHESPTWMinhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsara 253
Cdd:cd17356 161 LDGSAQ--WRIPLGLQIVWGLLL-LIGMFFLPESPRWL------------------------------------------ 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 254 lfqpkygKRLLLATAISTLQ---GMQYYAVglYIPII--ATYIISKEKLGVLLGTAIVNIAGIVGAYFgaqLTYRLGTRK 328
Cdd:cd17356 196 -------YRTILGIMLQLFQqltGINYFFY--YGTTIfqSTGLTGSSPLLTSIILYIVNFVSTIPGLF---FVDKFGRRT 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 329 LTIIGFALVLIAMVM---TGVFYHLLPMILNT----------FLIALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFV 395
Cdd:cd17356 264 CLLIGAAGMSICLFIyaaVGVRYLIPNPQSGTsnksagngmiVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALA 343
|
410 420
....*....|....*....|...
gi 488409712 396 EAVSRTGSIIGTFIFPIILAAVG 418
Cdd:cd17356 344 TAFNWLWNFLISFFTPFIIGSIG 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
50-440 |
4.50e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.30 E-value: 4.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 50 QLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGM 129
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 130 DSPVAFTFIAEISNRAQKGRnvnywqvvwYVAIVTSSLCVIAFFLMGTGSHL-----WRVAVGFGAIIALVLYLLRLKFL 204
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAK---------IFSLLMMILAIAPALAPLLGGLLllffgWRAIFVFLALLGLLLLLLVLLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 205 HESptwminhyslgqaADYIRQKYHVDIQLASNqtndvssqerqpsARALFQPKYGKRLLLATAIStlQGMQYYAVGLYI 284
Cdd:cd17320 175 PET-------------LPEEKRKPLLSSLLRAY-------------KRVLKNRRFLGYALALGLSF--AGLFAYLAAAPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 285 PIIATYIISKEKLGVLLGTAIvnIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPMILNTFLIALFL 364
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALNA--IALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488409712 365 FGHSGGpgtqgktigaLSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIITSAI 440
Cdd:cd17320 305 IFFGFG----------LIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-437 |
1.30e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 50 QLTQQFHLSPTMLSTVMTSLP-IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIG 128
Cdd:cd17473 24 AIAQHFVPNSELLVPLLLTLPaLFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 129 MDSPVAFTFIAEISNRAQKGRnvnywqVVWYVAIVTSSLCVIAFFLMGT-GSHLWRVAvgFGA-IIALVLYLLRLKFLHE 206
Cdd:cd17473 104 GIMTLATALIGDYFEGEERAK------MLGLQSAAMSLGGVVFLLLGGAlAEIGWRAP--FLVyLLALPVLILVLLFLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 207 SPTwminhyslgqaadyirqkyhvdiqlasnqtndvSSQERQPSARALFQPKYGKRLLLATAISTLQGMQYYAVGLYIP- 285
Cdd:cd17473 176 PAR---------------------------------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPf 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 286 -IIATYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPMILntfliALFL 364
Cdd:cd17473 223 lLQERGGGSAALIGLAL--AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLL-----GAIL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 365 FGHSGG---PGTQGKTIGALSFPtyLRSQATGFVEAVSRTGSIIGTFIF-PIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17473 296 AGLGFGlllPTLNSWAMSLVPPE--LRGRAMGIVTSAFFLGQFLSPLVLgPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
2-295 |
3.00e-12 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 68.85 E-value: 3.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 2 EIVKSKEDLFRIIDHADEQYTskmlLFMILGTIFL-DAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFG 80
Cdd:TIGR01299 147 ELAQQYELIIQECGHGRFQWA----LFFVLGLALMaDGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFW 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 81 GVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYV 160
Cdd:TIGR01299 223 GGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMI 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 161 AIVTSSLCVIAF-------FLMGTGS--HLWRVAVGFGAIIAlVLYLLRLKFLHESP-----------TWMI-------N 213
Cdd:TIGR01299 303 GGIYAAAMAWAIiphygwsFQMGSAYqfHSWRVFVIVCAFPC-VFAIGALTFMPESPrfflengkhdeAWMIlklihdtN 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 214 HYSLGQ-----AADYIRQKYHVD--IQLASnqtnDVSSQERQPSARAL-------------FQPKYGKRLLLATAISTLQ 273
Cdd:TIGR01299 382 MRAKGHpekvfSVNHIKTIHQEDelIEIES----DTGTWYQRCFVRALsegggiwgnflrcFNPEVREITIKLMGVWFTL 457
|
330 340
....*....|....*....|..
gi 488409712 274 GMQYYAVGLYIPIIATYIISKE 295
Cdd:TIGR01299 458 SFGYYGLSVWFPDMIKHLQADD 479
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
39-394 |
5.75e-12 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 66.93 E-value: 5.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 39 YDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGAL------IGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPN 112
Cdd:cd17367 13 YDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVgflmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 113 LT--------ILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHL--- 181
Cdd:cd17367 93 YAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaaw 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 182 -WRVAVGFGAIIALVLYLLRLKfLHESPtwminhyslgqaadyirqkyhvdiqlaSNQTNDVSSQERQPSARALFqpKYG 260
Cdd:cd17367 173 gWRIPFLLGGVLAVVVLWLRRG-LEETE---------------------------SFEAIAESNEASAGTLRELR--RHP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 261 KRLLLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIA 340
Cdd:cd17367 223 RELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488409712 341 MVMTGVFYHLLP-MILNTFLIALFLFGHSGGPGTQGkTIGALSFPTYLRSQATGF 394
Cdd:cd17367 303 TVPLLSALDHTDsPYTAFALVLVGLVFLSGYTSINA-VVKAELFPTHVRALGVGL 356
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
44-436 |
7.37e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 66.58 E-value: 7.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 44 LGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLM 123
Cdd:cd17333 15 LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 124 GMAIGMDSPVAFTFIAEISNRAQKGRNVnyWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKF 203
Cdd:cd17333 95 GLGAGILDTGANTFVGALFEESSATRLN--VLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 204 LHESPTwminhyslgqaadyirqkyhvdiqlasNQTNDVSSQERQPSARALFQPKYgkrLLLATAISTLQGMQyYAVGLY 283
Cdd:cd17333 173 PELPSA---------------------------RNPQQSVGAFSASASRLLRNPSI---ILGALALFLYVGAE-TAFSSW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 284 IPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPMILNTFLIALF 363
Cdd:cd17333 222 VPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLF 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488409712 364 LfghsGGPGTQGKTIGALSFPtYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLII 436
Cdd:cd17333 302 M----AALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
28-212 |
7.88e-12 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 66.87 E-value: 7.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 28 FMILG-TIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:cd17438 1 FFVLGlALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAF-------FLMGTGS 179
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIiphygwgFSMGTNY 160
|
170 180 190
....*....|....*....|....*....|....*
gi 488409712 180 HL--WRVAVGFGAIIALVlYLLRLKFLHESPTWMI 212
Cdd:cd17438 161 HFhsWRVFVIICALPCIA-SIIALKFMPESPRFLL 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-436 |
1.23e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.10 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 58 SPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL-----SPNLTILLLCRFLMGMAIGMDSP 132
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 133 VAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTS-SLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKFLHESPTWM 211
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGpALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 212 INHYSLGQAADYIRQKyhvdiqlasnqtndvssqerqpsaralfqpkygKRLLLATAISTLQGMQYYAVGLYIPIIATYI 291
Cdd:cd06173 192 LLLRDLREGLRYLRRS---------------------------------PLLRLLLLALALFALLGGALTVLLPLLAKEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 292 ISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLPmilntFLIALFLFGHSGGP 371
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL-----LLAALFLLGLAGGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488409712 372 -GTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLII 436
Cdd:cd06173 314 fNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
54-413 |
2.78e-11 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 65.10 E-value: 2.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 54 QFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAAL---------SPNLTILL---LCRF 121
Cdd:PRK10077 49 SESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWpefgftsigPDNTGYVPefvIYRI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 122 LMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQvvwyVAIVTSSLCV--IAFFLMGTGSHLWRVAVGF------GAIIA 193
Cdd:PRK10077 129 IGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQ----FAIIFGQLVVyfVNYFIARSGDASWLNTDGWrymfasEAIPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 194 LvLYLLRLKFLHESPTWMINHYSLGQAADYIRQKyhVDIQLASNQTNDV--SSQERQPSARALFQpkYGKRLLL-ATAIS 270
Cdd:PRK10077 205 L-LFLMLLYFVPETPRYLMSRGKQEQAEGILRKI--MGNTLATQALQEIkhSLDHGRKTGGKLLM--FGVGVIViGVMLS 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 271 TLQGMQYYAVGLYipiIATYIIskEKLGV-----LLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGfALVLiAMVMTG 345
Cdd:PRK10077 280 VFQQFVGINVVLY---YAPEIF--KTLGAstdiaLLQTIIVGVINLTFTVLAIMTVDKFGRKPLQIIG-ALGM-AIGMFS 352
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488409712 346 V---FYH----LLPMILNTFLIALFLFghSGGPGTQgkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPII 413
Cdd:PRK10077 353 LgtaFYTqapgIVALLSMLFYVAAFAM--SWGPVCW--VLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMM 423
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
75-437 |
3.63e-11 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 64.47 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 75 IGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNL--------TILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQ 146
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 147 KGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHL----WRVAVGFGAIIALVLYLLRLKfLHESPTwminhyslgqaad 222
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAFlswgWRIPFLLSAVLVAVGLYIRLR-LEETPV------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 223 yirqkyHVDIQLASnqtndvssQERQPSARALFQpKYGKRLLLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLG 302
Cdd:cd17369 205 ------FRRAKEAG--------QVVRAPLVEVLR-RHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 303 TAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGfalVLIAMVMTGVFYHLL----PMILNTFLIALFLFGHSGGPGTQGKTI 378
Cdd:cd17369 270 VLIASVVAAITIPLFGWLSDRVGRRPVYLAG---ALLAALFAFPFFWLLdtgsTWLIVLAAVVVLGVLHGMMYGPQAAFL 346
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 379 GALsFPTYLRSQATGFVEAVsrtGSIIGTFIFPIILAA-VGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17369 347 AEL-FPTRVRYTGASLGYQL---GAILGGGFAPLIATAlVAATGSWWPVALYLAALAVIS 402
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
71-212 |
7.41e-11 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 64.05 E-value: 7.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:cd17363 45 LGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEH 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409712 151 VNYWQVVWYVAIVTSSLCVIAF-------FLMGTGSHL--WRVAVGFGAIIAlVLYLLRLKFLHESPTWMI 212
Cdd:cd17363 125 LSWLCMFWMIGGLYASAMAWAIiphygwgFSMGTAYQFhsWRVFVIVCALPS-VASVVALTFMPESPRFLL 194
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-366 |
9.65e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.41 E-value: 9.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 26 LLFMILGTIFLDAYDITILGTMtdqLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSL 105
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPD---IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 106 GAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRnvnyWQVVWYVAI-VTSSLCVIAFFLMGTGSHLWRV 184
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR----ALGVFYFAIpLGSGLGYVVGGLVAQATGGWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 185 AVGFGAIIALVLYLLRLKFLHESPtwminhysLGQAADYIRQKYHVDIQLAsnqtndvssqerqpSARALFQPKYGKRLL 264
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPP--------RGAAEGGVMAKSTATSFLA--------------DLKALAKNPSFILST 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 265 LATAISTLQGmqyYAVGLYIP-----IIATYIISKEKLGVLLGtAIVNIAGIVGAYFGAQLTYRLgtRKLTIIGFALVL- 338
Cdd:cd17328 214 LGFTAVSFVT---GALAFWAPtfflrAFGVGDLSSADVGLIFG-AITCIAGVLGVLLGGILADRL--RRKTPRADPLVCa 287
|
330 340
....*....|....*....|....*...
gi 488409712 339 IAMVMTGVFYHLLPMILNTFLIALFLFG 366
Cdd:cd17328 288 VGLLAAAPFLFLALVLALSNLLLAWVLL 315
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-437 |
2.71e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.82 E-value: 2.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 105 LGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIafFLMGTGShlWRV 184
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG--WLLLLFG--WRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 185 AVGFGAIIALVLYLLRLKFLhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygkRLL 264
Cdd:cd17319 159 AFIIEGLLGLLLAVLWWFYL---------------------------------------------------------RQV 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 265 LATAISTLqGMQYYAVGL--YIP--IIATYIISKEKLGVLlgTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIA 340
Cdd:cd17319 182 WGLALGYF-GINYALYGLltWLPtyLKQARGFSLKQVGLL--AAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 341 MVMTGVFYHLLPMILNTFLIALFLFGHSGGPGTqGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLT 420
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV-FWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSY 337
|
410
....*....|....*...
gi 488409712 421 NT-MLILSIVPLVGLIIT 437
Cdd:cd17319 338 TAaFLFLAAVALLAALLV 355
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-440 |
2.75e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.23 E-value: 2.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 26 LLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFA----HRFGRKR-------ILS 94
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRpwiligaIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 95 ISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEIS-NRAQKGRNVNYWQVVWYVAIVTSSLCVIAFF 173
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 174 LMGTGSHL--WRVAVGFGAIIALVLYLLRLKFLHESPTWMINHYSLGQaadyirqkyhvdiqlasnqtndvssqerqpSA 251
Cdd:COG2211 172 AAFGGDAAlgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE------------------------------SL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 252 RALFQPKYGKRLLLATAISTLQGMQYYAVGLYIpiiATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTI 331
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYY---FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 332 IGFALVLIAMVmtgVFYHLLPMILNTFLIALFLFGHSGGPGT------QGKTI--GALSFPTYLRSQATGFVEAVSRTGS 403
Cdd:COG2211 299 IGLLLAALGLL---LLFFLGPGNLWLLLVLAALAGIGLGAILvlpwamLADVVdyDEWKTGRRREGLYFGIFTFAIKLGQ 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 488409712 404 IIGTFIFPIILAAVG-----------LTNTMLILSIVPLVGLIITSAI 440
Cdd:COG2211 376 ALAGALAGLLLALFGyvagaaqspsaLTGIRLLFFLLPAVLLLLAALL 423
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
61-438 |
3.11e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 61.44 E-value: 3.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 61 MLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAE 140
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 141 ISNRAQKGRNVNYWQVVWYVAIVtsSLCVIAFFLmGTGSHLWRVAVGFGAIIALVLYLLRLKFLHESPTWMINHyslgqa 220
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYM--LLALLAYLI-RDWRWLQLAISLPGLLFLLLLWWLPRRTIIVGLIWFVTS------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 221 adyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygkrlllataistlqgMQYYAVGLYIPIIATYIiskeklgvL 300
Cdd:cd17317 177 ------------------------------------------------------LVYYGLSLNSSNLGGNL--------Y 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 301 LGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGvfyhLLPMILNTFLIALFLFGHSGGPGTQG--KTI 378
Cdd:cd17317 195 LNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTA----LLPDDENTLALTLALVGKFAISAAFSviYLY 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 379 GALSFPTYLRSQATGFVEAVSRTGSIIGTFIFpiILAAVGLTNTMLILSIVPLVGLIITS 438
Cdd:cd17317 271 TAELYPTVVRNTGVGLCSTVARVGAILAPFIV--LLGKIGPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
53-199 |
3.60e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 53 QQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSP 132
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 133 VAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLL 199
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
54-199 |
8.04e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.26 E-value: 8.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 54 QFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPV 133
Cdd:cd17477 25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488409712 134 AFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFflmGTGSHLWRVAVGFGAIIALVLYLL 199
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV---GTAGALPFLIAAVLLLLALVPLLL 167
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-437 |
8.84e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 8.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 53 QQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSP 132
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 133 VAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKFLHESPTwmi 212
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPA--LGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 213 nhyslgqaadyirqkyhvdiqlasnqtndvssqERQPSARALFQPKYGKRLLLATAISTLQGMQYYAVGLYIPIIATYII 292
Cdd:cd17489 179 ---------------------------------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 293 SKEKLGVLLGTAivnIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGvFYHLLPMilntFLIALFLFGHSGG-- 370
Cdd:cd17489 226 ISNAGLFFTVYA---IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS-FAGSPWM----LLLAAVLYGLGFGll 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488409712 371 -PGTQGKTIGALsfPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17489 298 fPALQALAVDLV--PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
36-212 |
1.57e-09 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 59.43 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 36 LDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTI 115
Cdd:cd17435 12 LVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 116 LLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFflmGTGSHLWRVAVGfGAIIALV 195
Cdd:cd17435 92 LIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAF---ANVSNGWKYMFG-LVIPLAA 167
|
170
....*....|....*..
gi 488409712 196 LYLLRLKFLHESPTWMI 212
Cdd:cd17435 168 LQAIAMYFLPPSPRFLV 184
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
50-366 |
1.95e-09 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 59.27 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 50 QLTQQFHLSPTMLStvmtslpIGALIGAIFGGVFAHRFGRKR-ILSISLLALVITSLG--AALSPNLTILLLCRFLMGMA 126
Cdd:cd17431 47 TLTTLWSLSVAIFS-------VGGMIGSFSVGLFVNRFGRRNsMLYNNLLAFAGAALMglSKLAKSYEMLILGRFIIGLY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 127 IGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAfFLMGTGShLWRVAVGFgAIIALVLYLLRLKFLHE 206
Cdd:cd17431 120 CGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLE-FILGTEE-LWPLLLGF-TIVPAILQLALLPFCPE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 207 SPTWMINHYSLGQAADYIRQK----YHVDIQLAS-NQTNDVSSQERQPSARALFQ-PKYGKRLL------LATAISTLQG 274
Cdd:cd17431 197 SPRYLLINRNEEEEAKSVLKKlrgtTDVSEDIQEmKEESRQMMREKKVTILELFRsSSYRQPIIiaivlqLSQQLSGINA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 275 MQYYAVGLYI------PIIATyiiskeklgvlLGTAIVNIAGIVGAYFgaqLTYRLGTRKLTIIGFALVLI-AMVMTGVF 347
Cdd:cd17431 277 VFYYSTSIFEkagvqqPVYAT-----------IGAGVVNTIFTVVSLF---LVERAGRRTLHLIGLGGMAIcAILMTIAL 342
|
330
....*....|....*....
gi 488409712 348 YHLLPMILNTFLIALFLFG 366
Cdd:cd17431 343 LLLEGYPWMSYVSIVAIFG 361
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
60-372 |
2.98e-09 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 58.78 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 60 TMLSTVMTSL-PIGALIGAIFGGVFAHRFGRKRIL----SISLLALVITSLG-AALSPNLtiLLLCRFLMGMAIGMDSPV 133
Cdd:cd17432 49 TLLWSLTVSIfPLGGLFGSLLVGPLVIRLGRKGTLllnnIFAIVAAILMGLSkIAKSFEM--IIVGRFLVGINAGISLNV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 134 AFTFIAEISNRAQKGrnvnywqvvwYVAIVTSSLCVIAFF---------LMGTGSHlWRVAVGFGAIIAlVLYLLRLKFL 204
Cdd:cd17432 127 VPMYLGESAPKNLRG----------AVGLVPAIFITLGILlgqvlglreLLGNEEG-WPLLLALTGVPA-LLQLLTLPFF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 205 HESPTWMI----NHYSLGQAADYIRQKYHVDIQLASNQTNDVSSQERQP-SARALFQPKYGKRLLLaTAISTLQGMQYYA 279
Cdd:cd17432 195 PESPRYLLiekgDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKGVGTvSVLELFRDRSVRWQLI-SIIVLMAGQQLCG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 280 VGLyIPIIATYI-----ISKEKLG-VLLGTAIVNI-AGIVGAYFgaqlTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLP 352
Cdd:cd17432 274 INA-IYFYADSIfleagIPEDKIQyVTVGTGACEVlATITCVLV----IERLGRRPLLIGGFGLMAVWCAVLTVALSLQN 348
|
330 340
....*....|....*....|....*
gi 488409712 353 MI-----LNTFLIALFLFGHSGGPG 372
Cdd:cd17432 349 TVswmpyLSIVCIFAYIASFGIGPA 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-437 |
3.29e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 51 LTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMD 130
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 131 SPVAFTFIAEISnRAQKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKFLHESPTw 210
Cdd:cd17478 102 HPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPL-IAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 211 minhyslgqaadyirqkyhvdiqlasnqtndvsSQERQPSARALFQPKYGKRLLLaTAISTLQGMQYYAVGLYIPI-IAT 289
Cdd:cd17478 179 ---------------------------------KAAAKSSARSTLKGVWRALLLL-LIIVFLRSWVLSSLTTFLPFyLVQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 290 YIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTgVFYHLLPMILNTFLIALFLFghsg 369
Cdd:cd17478 225 RGYSLVFAGLLL--SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF-LLTPGIWSYILLVLAGFLLF---- 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488409712 370 GPGTQGKTIGALSFPTYlRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17478 298 ASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
34-149 |
4.41e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.97 E-value: 4.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 34 IFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNL 113
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110
....*....|....*....|....*....|....*.
gi 488409712 114 TILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGR 149
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGA 120
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-436 |
4.43e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.01 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 26 LLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLL--ALVIT 103
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLlrALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 104 SLGAALSPNLTILLLcrFLMGMAIGMDSPVAFTFIAEISNRAQKGR--NVNYWQVvwYVAIVTSSLCVIAFFLMGTGSHL 181
Cdd:cd17329 81 LLGFAHSPWLFAIAL--VLTGFGGGLFEPASEAMIADVTTPENRTRafSLLYWAI--NLGVAIGPLLGGLLLLYSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 182 WRVAVGFGAIIALVLYLLRLKFLHESPtwminhyslgqaadyirqkyhvdiqlasnqtndvssQERQPSARALFQPKYGK 261
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETRPKRRA------------------------------------AEKTEILRGYKIVLRDR 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 262 RLLLATAISTLQGMQYYAVGLYIPIIA--TYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLI 339
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPVYVveILGLGESLLGLLL--ALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 340 AMVMTGVFYHLLPMILNTFLIAL---FLFGHSGgpgtqgkTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAA 416
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLgemLVFPAVQ-------TLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
|
410 420
....*....|....*....|
gi 488409712 417 VGLTNTMLILSIVPLVGLII 436
Cdd:cd17329 352 LGPGLPWLILAALGLIAAAL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-438 |
4.87e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.59 E-value: 4.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 30 ILGTIFLDAYDITILGTMTDQLTQQF---HLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSPNLTILLLCRFLMGMAIGmDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTGSHLWRVAV 186
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPA--LGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 187 GFG-AIIALVLYLLRLKFLhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygKRLLL 265
Cdd:cd17330 158 AAAlALLNLVLVLFFLPPL--------------------------------------------------------RRLLL 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 266 ATAISTLQGMQYYAVgLYIPIIATYIISKEKLGVLLgtAIVNIAGIV-GAYFGAQLTYRLGTRKLTIIGFALVLIAMVMT 344
Cdd:cd17330 182 VYFLIALAFAGLESV-FSLFLKDRFGFSPSQIGLLL--ALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 345 GV---FYHLLPMILNTFLIALFLFghsggPGTQGktIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTN 421
Cdd:cd17330 259 PFassVPLLVLAAAILAFGTGIVF-----PALSA--LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV 331
|
410
....*....|....*..
gi 488409712 422 TMLILSIVPLVGLIITS 438
Cdd:cd17330 332 PFLLAAGLLLIALFLLS 348
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
71-212 |
6.04e-09 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 58.00 E-value: 6.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:cd17440 45 LGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEH 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488409712 151 VNYWQVVWYVAIVTSSLCVIAF-------FLMGTGS--HLWRVAVGFGAiIALVLYLLRLKFLHESPTWMI 212
Cdd:cd17440 125 LSWLCMFWMIGGIYASAMAWAIiphygwsFSMGSAYqfHSWRVFVIVCA-LPCVSSVVALTFMPESPRFLL 194
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
35-441 |
8.50e-09 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 57.38 E-value: 8.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLP---IGAL---IGAIFGGVFAHRFGRKRILSISLLALVITSLGAA 108
Cdd:cd17368 9 ALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFAtfgVGFFmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 109 LSPNLT--------ILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGSH 180
Cdd:cd17368 89 LAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLTAEA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 181 L----WRVAVGFGAIIALVLYLLRLkflhesptwminhyslgqaadyirqkyhvdiqlasNQTNDVSSQERQ--PSARAL 254
Cdd:cd17368 169 LaewgWRIPFFIGLLIIPLGLWLRR-----------------------------------SLEETEAFLERKarPTRREL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 255 FQ--PKYGKRLLLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTII 332
Cdd:cd17368 214 FAllANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLV 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 333 GFALVLIAM--VMTGVFYHLLPMILNTFLIAL-FLFGHSGGPgtqgkTIGAL--SFPTYLRSqaTGFVEAVSRTGSIIGT 407
Cdd:cd17368 294 ITLAALVTLypVFAWLTAAPSFGRLLLVLLVLsFFFGMYGGA-----MVVALveLFPVRVRS--TGFSLVYALAVAIFGG 366
|
410 420 430
....*....|....*....|....*....|....*...
gi 488409712 408 FIFPIILAAVGLTNTML----ILSIVPLVGLIITSAIK 441
Cdd:cd17368 367 FAQFIVTWLIELTGSPLapawYLMGAALLGLLATLMLR 404
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
39-450 |
8.91e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 57.03 E-value: 8.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 39 YDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLL 118
Cdd:cd17437 11 YDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 119 CRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSlcVIAFFLMGTGSHL-WRVAVGFGAIIALVLY 197
Cdd:cd17437 91 GRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGY--VSNYAFSGLPLHVgWRLMLGVGAVPSLFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 198 LLRLkFLHESPTWminhyslgqaadyirqkyhvdiqlasnqtndvssqerQPSARalfqpkygKRLLLATAISTLQ---G 274
Cdd:cd17437 169 IGVL-AMPESPRW-------------------------------------TPAVR--------RMLIAALGIHFFQqasG 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 275 MQyyAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKL---TIIGFALVLIAMVMTGVFYHLL 351
Cdd:cd17437 203 ID--AVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLlltSTGGMTLSLTALATSLTFIDRN 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 352 PM------ILNTFLIALFLFGHSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLI 425
Cdd:cd17437 281 GGgltwalVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFL 360
|
410 420
....*....|....*....|....*
gi 488409712 426 LSIVPLVGLIITSAIKWEPVGKNVE 450
Cdd:cd17437 361 FAGVAAAAWVFFYFFLPETKGKSLE 385
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
71-207 |
1.48e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.42 E-value: 1.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488409712 151 VNYWqvvwyVAIVTSSLCVIAFF--LMGTGSHlWRVAVGFGAIIALVLYLLRLKFLHES 207
Cdd:TIGR00880 89 LGLM-----SAGIALGPLLGPPLggVLAQFLG-WRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
26-141 |
2.24e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 55.66 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 26 LLFMILGTIFLDAYDITILGTMTDQltqqFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSL 105
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQRE----FGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSL 76
|
90 100 110
....*....|....*....|....*....|....*.
gi 488409712 106 GAALSPNLTILLLCRFLMGMAIGMdSPVAFTFIAEI 141
Cdd:cd17504 77 LAAFAPNLPVLIAGRALQGIGGAV-FPLAFALVREE 111
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
42-204 |
2.87e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 55.27 E-value: 2.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 42 TILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRF 121
Cdd:cd17323 16 SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 122 LMGMAIG-MDSPVAFTfIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGshlWRVAVGFGAIIALVLYLLR 200
Cdd:cd17323 96 LQGFFGSsPLAIGAGT-IADLFTPEERGKAMGVYSLGPLLGPALGPI-IGGFITQSLG---WRWIFWFLAIISGFCLILI 170
|
....
gi 488409712 201 LKFL 204
Cdd:cd17323 171 FLFL 174
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
28-291 |
2.90e-08 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 55.81 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 28 FMILG-TIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:cd17439 1 YFVLGlALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAF-------FLMGTGS 179
Cdd:cd17439 81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIiphygwsFQMGSAY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 180 --HLWRVAVGFGAIIAlVLYLLRLKFLHESPTWminhyslgqaadYIRQKYHVDIQLASNQTNDVSSQERQPSARALFQP 257
Cdd:cd17439 161 qfHSWRVFVLVCAFPS-VFAIGALTTMPESPRF------------FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVT 227
|
250 260 270
....*....|....*....|....*....|....*
gi 488409712 258 KYGKRL-LLATAISTLQGMQYYAVGLYIPIIATYI 291
Cdd:cd17439 228 HIKRRItLMMMAVWFTMSFSYYGLTVWFPDMIKHL 262
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
56-127 |
4.80e-08 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 54.60 E-value: 4.80e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488409712 56 HLSPTMLSTVMtslpIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAI 127
Cdd:cd17374 35 SLKSVAQSIFM----AGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
51-200 |
5.97e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 5.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 51 LTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMD 130
Cdd:cd17473 224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488409712 131 SPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGSHL--WRVAVGFGAIIALVLYLLR 200
Cdd:cd17473 304 LPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL-VLGPLVNLTGGLSgaFLILGVLALVLAIVLLLLR 374
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
62-208 |
8.25e-08 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 54.18 E-value: 8.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 62 LSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEI 141
Cdd:cd17361 53 LQLFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEM 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 142 SNRAQKGRNVNYWQVVWYVAIVTSSLcvIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLkFLHESP 208
Cdd:cd17361 133 APAKLRGALNIGFQLAITIGILIANL--INYGTSKIKPNGWRLSLGLAAVPALILLLGSL-FLPETP 196
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
39-208 |
9.12e-08 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 54.04 E-value: 9.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 39 YDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLL 118
Cdd:cd17436 15 YELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 119 CRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLMGTGshlWRVAVGFgAIIALVLYL 198
Cdd:cd17436 95 GRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVLTG---WRYMFGL-AIIPAAIQF 170
|
170
....*....|
gi 488409712 199 LRLKFLHESP 208
Cdd:cd17436 171 ASILLLPKKP 180
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
51-208 |
1.24e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.53 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 51 LTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMD 130
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488409712 131 SPVAFTFIAEISNRAQKGRNVNYWQVVWYVA-IVTSSLCVIAFFLMGTgshlWRVAVGFGAIIALVLYLLRLKFLHESP 208
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYS----WHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
33-425 |
1.38e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 53.34 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 33 TIFLDAYDITILGTMTDQLTQQFHlSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPN 112
Cdd:cd17502 4 ALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 113 LTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAivtsslCVIAFFLMG--TGSHLWRVAVGFG- 189
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIA------SVAGPLIGGafTDHLSWRWCFYINl 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 190 AIIALVLYLLRLkflhesptwminhyslgqaadyirqkyhvdiqlasnqtndvssqerqpsaralfqpkygkrLLLATAI 269
Cdd:cd17502 157 PIGGLALALLRT-------------------------------------------------------------ILLSSIF 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 270 STLQGMQYYAVGLYIPII--ATYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLG-TRKLTIIGFALVLIAMvmtGV 346
Cdd:cd17502 176 GFLFGGALFGLIYYLPLYfqLVLGDSATKSGVRL--LPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSVGA---GL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 347 FYHLLPMILNTFLI-ALFLFGHSGGPGTQGKTIGA-LSFPTYLRSQATGFVEAVSRTGSIIG-----TFIFPIILAAVGL 419
Cdd:cd17502 251 LTTLTLDTSKWLLIgYLILLGLGLGIGFQQPLVAVqNAVPPADVGVATATNTFFRSLGGTLGvaitdVFLVALALAALAF 330
|
....*.
gi 488409712 420 TNTMLI 425
Cdd:cd17502 331 LLSLFL 336
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
25-161 |
1.60e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 53.54 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTiFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:TIGR00711 3 LTIVLMLGT-FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 105 LGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVA 161
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVA 138
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-201 |
1.80e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTIFLDAYdITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGG-VFAHRFGRKRILSISLLALVIT 103
Cdd:cd17474 200 LLTFLVSAFLYFFLY-FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 104 SLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSlcVIAFFLMGTGSHLWR 183
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP--LLFGLLLEIFGLSAP 356
|
170
....*....|....*...
gi 488409712 184 VAVGFGAIIALVLYLLRL 201
Cdd:cd17474 357 FLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-141 |
1.93e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 24 KMLLFMILGTIFLDAYDITILGTMTDQLtqqfHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVIT 103
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVL----GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488409712 104 SLGAALSP--NLTILLLCRFLMGMAIGMDSPVAFTFIAEI 141
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADV 347
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
61-125 |
2.21e-07 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 52.35 E-value: 2.21e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488409712 61 MLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGM 125
Cdd:cd17379 34 KLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGL 98
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
72-127 |
2.68e-07 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 52.42 E-value: 2.68e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 488409712 72 GALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAI 127
Cdd:cd17446 45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMAL 100
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
37-199 |
3.83e-07 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 52.12 E-value: 3.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 37 DAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTIL 116
Cdd:cd17441 11 DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 117 LLCRFLMGMAIGmDSPVAFTFIAEISNRAQKGRNVNYWQVVWyvAIVTSSLCVIAFFLMGTGShlWRVAVGFGAIIALVL 196
Cdd:cd17441 91 LVLRGLVGFGIG-GVPQSVTLYAEFLPMKSRAKCILLIEVFW--ALGTVFEVLLAVFVMPTLG--WRWLLILSALPLLIF 165
|
...
gi 488409712 197 YLL 199
Cdd:cd17441 166 AVL 168
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
35-126 |
4.01e-07 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 51.96 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 35 FLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLT 114
Cdd:cd17396 10 FVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI 89
|
90
....*....|..
gi 488409712 115 ILLLCRFLMGMA 126
Cdd:cd17396 90 IAYVFALLAGAA 101
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
37-435 |
6.19e-07 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 51.38 E-value: 6.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 37 DAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTIL 116
Cdd:cd17372 11 EAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 117 LLCRFLMGMAIGmDSPVAFTFIAEISNRAQKGRNVNYWQVVWyvAIVTSSLCVIAFFLMGTGSHLWRVAVgfgAIIALVL 196
Cdd:cd17372 91 IILRCLVGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFW--TVGTIFEASLAWLVMPRLGWRWLLAF---SSVPSSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 197 YLLRLKFLHESpTWMINHYSLGQAADYirqkYHVDIQLAS-NQTNDVSSQERQPSARALFQPKYgkrlllataistlqgM 275
Cdd:cd17372 165 LLVFYRWTPKT-TLLLWVIWFGNAFAY----YGVVLLTTElNNSHNVCGSKSDSDSGESPTEKQ---------------C 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 276 QYYAVGLYIPIIATYIisKEKLGVLLGTAIVNiagivgayfgaqltyRLGtRKLTIIgfalvlIAMVMTGVFYHLLPMIL 355
Cdd:cd17372 225 RNSNDVDYRDVFIATF--AEFPGLLISAAMID---------------RLG-RKASMA------SMLFTCCIFLLLLLICQ 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 356 NTFLIALFLFGHS---GGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAvGLTNTMLILSIVPLV 432
Cdd:cd17372 281 SPFILTVLLFGGRaciSAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHG-SQTIALLLFSVVCLV 359
|
...
gi 488409712 433 GLI 435
Cdd:cd17372 360 SAI 362
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
50-216 |
9.02e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 9.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 50 QLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILsisLLALVITSLGAALSP-----NLTILLLCRFLMG 124
Cdd:cd17380 24 PMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVL---LLAVALWSLATLLTPllaysSLPLLILSRILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 125 MAIGMDSPVAFTFIAEISNRAQKGRNvnywqvvwyVAIVTSSLCVIAFFLMGTGSHL-----WR-VAVGFGaIIALVLYL 198
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRA---------VSIVTAGSYLGTLLGGLIGPLLleyygWPsVFYFFG-LLGLLWAL 170
|
170 180
....*....|....*....|
gi 488409712 199 LRLKFLheSPTW--MINHYS 216
Cdd:cd17380 171 VWLIYL--PPVWaiIVAHFC 188
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-429 |
3.27e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.19 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 51 LTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMA-IGM 129
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 130 DSPVAFTFIAEISNRAQKGrnvnywqvvWYVAIVTSSLCVIAFFLMGTGSHL-----WRVAVGFGAIIALVLYLLRLKFL 204
Cdd:cd17355 109 LAAVAFATVAAWWFERRRG---------LALGILTAGGGLGSLVFLPLGAALieafgWRTALLVLALLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 205 HESPtwminhyslgqaadyirqkyhvdiqlASNQTNDVSSQERQPSARALFQPKYGKRLLLATAISTLQGMQYYAVGL-Y 283
Cdd:cd17355 180 RRRP--------------------------ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVhL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 284 IPIIATYIISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMvmtgVFYHLLPMILNTFLIALF 363
Cdd:cd17355 234 VPYLADRGISPAAAAVAL--ALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGL----ALLLLLPFPPLALLLFAA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488409712 364 LFGHSGGpGTQGKTIGALSFPTYLRSQAT--GFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIV 429
Cdd:cd17355 308 LFGLGWG-ATVPLTAALAARYFGARSYGTlfGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA 374
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
41-128 |
6.37e-06 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 48.00 E-value: 6.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 41 ITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCR 120
Cdd:PRK03699 23 VIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAM 102
|
90
....*....|....
gi 488409712 121 FLMG------MAIG 128
Cdd:PRK03699 103 FVLGvvsgitMSIG 116
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-198 |
6.98e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 22 TSKMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALV 101
Cdd:cd17324 196 RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 102 ITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAqKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGSHL 181
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAA-LGGLVLDHGGWAG 353
|
170
....*....|....*..
gi 488409712 182 WRVAVGFGAIIALVLYL 198
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
71-450 |
7.94e-06 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 47.91 E-value: 7.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:cd17434 52 LGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGAL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 151 VNYWQVVwyvaIVTSSLCVIAFFLMGTgshlWRVAVGFGAIIALVLYLLrLKFLHESPTWMI---NHYSLGQAADYIRQK 227
Cdd:cd17434 132 GACPQIM----AVFGSLALYALGLLLP----WRWLAVAGEVPVVIMILL-LCFMPNSPRFLIskgKDEKALKALAWLRGP 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 228 yHVDIQLASNQTND-VSSQERQPSARALFQPKYGKRLLLATAISTLQGMQ-YYAVGLYIPII--ATYIISKEKlgvlLGT 303
Cdd:cd17434 203 -NTDYMTEFEQIKDnIRKQSSRLSWAELKTPSYYKPILIAVVMRFLQQLTgITPILVYLEPIfhLTAVILEPK----YDA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 304 AIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGvfyhLLPMIlntfLIALFLFGHSGGPGTQGKTIGALSF 383
Cdd:cd17434 278 ALVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMG----LIPLI----AAMLFIMGYAMGWGPITWLLMSEIL 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 384 PTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIITSAIKWEPVGKNVE 450
Cdd:cd17434 350 PLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-141 |
1.15e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 24 KMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVIT 103
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488409712 104 S--LGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEI 141
Cdd:cd17316 257 AlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-163 |
2.76e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 27 LFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLG 106
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 107 AALSP---NLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIV 163
Cdd:pfam07690 282 LLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
25-128 |
2.98e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 46.30 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTIFLDAYDiTILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:COG2270 240 LLRFLLAYFFYRDGVQ-TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVC 318
|
90 100
....*....|....*....|....
gi 488409712 105 LGAALSPNLTILLLCRFLMGMAIG 128
Cdd:COG2270 319 LAAYFLTTALAFWILGLLIGLVMG 342
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
53-129 |
3.06e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.10 E-value: 3.06e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 53 QQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGM 129
Cdd:cd17393 27 DRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGA 103
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
21-440 |
4.35e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.45 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 21 YTSKMLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLAL 100
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 101 VITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLcVIAFFLMGTGSH 180
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPL-LGGYILVWLSWH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 181 LWRVAVGFGAIIALVLYLLRLKFLHESPTWMINHYSLGQAADYIRQkyhvdiqlasnqtndvssqerqpsaralfqpkyg 260
Cdd:TIGR00710 160 AIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKS---------------------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 261 KRLLLATAISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALvLIA 340
Cdd:TIGR00710 206 KMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLIL-FAV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 341 MVMTGVFYHLLPMILNTFLIALFLFghsggpgtQGKTIGALSfPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLT 420
Cdd:TIGR00710 285 SAVLLEITAILGLGSWAMIIGPMMF--------VGIGNSMIS-SIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLV 355
|
410 420
....*....|....*....|
gi 488409712 421 NTMLILSIVPLVGLIITSAI 440
Cdd:TIGR00710 356 SLIHGNTAWPMSLSCLVLAV 375
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
292-441 |
4.79e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.53 E-value: 4.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 292 ISKEKLGVLLgtAIVNIAGIVGAYFGAQLTYRLGTRKlTIIGFALVLIAMVMTGVFYHLLPMilntFLIALFLFGHSGGP 371
Cdd:COG2270 271 FSTTELIVFG--LLVQIVAALGALLFGRLDDRIGPKR-VILVSLVIWIVVCLAAYFLTTALA----FWILGLLIGLVMGG 343
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488409712 372 gtqgktIGALSFPTYLR-------SQATGFVEAVSRTGSIIGTFIFPIILAAVG-LTNTMLILSIVPLVGLIITSAIK 441
Cdd:COG2270 344 ------IQALSRSLLARlippgreAEFFGLYALSGKAASFLGPLLFGLVTQLTGsQRLGILSLIVFFVIGLVLLLRVK 415
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
50-224 |
5.59e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.96 E-value: 5.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 50 QLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGM 129
Cdd:cd17312 28 PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSM 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 130 DSPVAFTFIAEISNRAQKGRnvnyWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKFLHESPt 209
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGT----VYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP- 182
|
170
....*....|....*
gi 488409712 210 WMINHYSLGQAADYI 224
Cdd:cd17312 183 PYVWVLSLAYAFVYI 197
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
263-436 |
6.33e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 263 LLLATAISTLQGMQYYAVGLYIPIIATYI-ISKEKLGVLLGTAIvnIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAM 341
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLgASPAQAGLVVTAYL--LGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 342 VMTGVFYHLLPMILNTFLIALFlfghSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTN 421
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLG----AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170
....*....|....*
gi 488409712 422 TMLILSIVPLVGLII 436
Cdd:COG2814 166 VFLVNAVLALLALLL 180
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
56-437 |
8.45e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 8.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 56 HLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFG-RKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMdsPVA 134
Cdd:cd17490 27 GASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAT--WVS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 135 FT-FIAEISNRAQKGRNVNYWQVVWYVAIVTSSL-CVIAFFLMGtgshlWRVAVGFGAIIALVLYLLRLKFLHESPTWMI 212
Cdd:cd17490 105 FTvLYASYFPPDEAAKAMGLINLVNNLGQLIAFLiGGLIAEHFG-----MRAPFLLAALAGVLGFILSLFIKEERREKKP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 213 nhyslgqaadyirqkyhvdiqlASNQTNDVSSQERQpsaralfqpkygKRLLLATAIS-TLQGMQYYAVGLYIPIIATYI 291
Cdd:cd17490 180 ----------------------VLTELKELLSVLKD------------KKLLFFSLLAiLQQMITFSTTFGFTPLIAKQL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 292 -ISKEKLGVLLGTAIvnIAGIVGAYFGAQLTY-RLGTRKLTIIGFALvliamvmTGVFYHLLPMI--LNTFLIALFLFGH 367
Cdd:cd17490 226 gASSFQLGLLSIIYL--LPNALASLLSGTLFYkKLGERNTIIIGFLL-------LGAYCFLIPFApnLTLLYLLQALNGF 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488409712 368 SGG---PGTQGKTIGalSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17490 297 GTGilfPLLMSLSIE--GVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
72-201 |
1.15e-04 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 44.00 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 72 GALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAqkgrnv 151
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKS------ 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488409712 152 nYWQVVWYVAIVTSSLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRL 201
Cdd:cd17377 125 -YWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSL 173
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
27-207 |
1.36e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 27 LFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLST---VMTSLpiGALIGAIFG---GVFAHRFGRKRILSISLLAL 100
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAAThygVLLAL--YALMQFIFApilGALSDRFGRRPVLLLSLAGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 101 VITSLGAALSPNLTILLLCRFLMGMAiGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSlcVIAFFLMGTGSH 180
Cdd:cd17388 79 ALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGP--ALGGLLGEISPR 155
|
170 180
....*....|....*....|....*..
gi 488409712 181 LwrvAVGFGAIIALVLYLLRLKFLHES 207
Cdd:cd17388 156 A---PFLVAAGLNGLNFLLGLFVLPES 179
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
71-450 |
1.95e-04 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 43.71 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRN 150
Cdd:cd17433 52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 151 VNYWQVVWYVAIVTSSLCVIAFflmgtgshLWRVAVGFGAIIAlVLYLLRLKFLHESPTWMINHYSLGQAADYIR--QKY 228
Cdd:cd17433 132 GSCVQLMVVIGIMGAYLAGLVL--------DWRWLAVLGSIPP-TLMLLLMCFMPETPRFLLTQHRRQEAMAALRflRGP 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 229 HVDIQLASNQTNDVSSQERQPSARALF-QPKYGKRLLLATAISTLQGMQ-YYAVGLYIPIIATYIISKEKlgvLLGTAIV 306
Cdd:cd17433 203 DQGWEWECIGIEQSFHLEEQSFSLALLkQPGIYKPLIIGVSLMAFQQLTgINAVMFYAETIFEEAKFKDS---SVASVIV 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 307 NIAGIVGAYFGAQLTYRLGTRKLTIigfaLVLIAMVMTGVFYHLLPMILNTFLIALFLFGHSGGPGTQGKTIgalsFPTY 386
Cdd:cd17433 280 AAIQVLFTAVAALIMDRAGRKVLLV----LSGVVMVFSTAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEI----FPLH 351
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488409712 387 LRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIITSAIKWEPVGKNVE 450
Cdd:cd17433 352 VRGVASGICVLTNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
55-438 |
2.19e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.38 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 55 FHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVA 134
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 135 FTFIAEISNRAQKGRNVNYWQvvwyvAIVTSSLCVIAFFLMGTGSHL-WRVAVGFGAIIALVLYLLRLKFLHESPtwmin 213
Cdd:cd17475 106 GRAIMRWFPPRERGLAMGIRQ-----TGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLFYREPP----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 214 hyslgqAADYIRQKyhvdiqlasnqtndvsSQERQPSARALFQpkYGKRLLLATAISTLQGMQYyavglyipIIATYII- 292
Cdd:cd17475 176 ------AASAATES----------------ASTLLRSLKEVLR--NRDVWLIAIAGALLVAPQF--------ALLTFLLl 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 293 -SKEKLGVLLGTA-----IVNIAGIVGAYFGAQLTYRL--GTRK--LTIIGF--ALVLIAMVMTGVFYHLLPMILNTFLI 360
Cdd:cd17475 224 fLHDHLGLSVVAAgallaVAQLGGALGRIGLGRVSDRVfgGRRRpvLVITAAiaAAALLVLSLLSPGTPLWLLVLLLILL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488409712 361 ALFLFGHSGgpgtQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTM-LILSIVPLVGLIITS 438
Cdd:cd17475 304 GLFAIGWNG----LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAwLALALLLVLAALLLL 378
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-167 |
2.74e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 65 VMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNR 144
Cdd:cd17391 245 VFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPK 324
|
90 100
....*....|....*....|...
gi 488409712 145 AQKGRNVNYWQVVWYVAIVTSSL 167
Cdd:cd17391 325 EVAGRIFGYNQSFQYLGNVAGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-436 |
2.87e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 269 ISTLQGMQYYAVGLYIPIIATYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFY 348
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 349 HLLPMILNTFLIALFlfghSGGPGTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSI 428
Cdd:pfam07690 84 SLWLLLVLRVLQGLG----AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
....*...
gi 488409712 429 VPLVGLII 436
Cdd:pfam07690 160 LSLLAAVL 167
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
25-340 |
3.21e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.01 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILgtiFLDAYDIT---ILGTMTDqltqqFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALV 101
Cdd:cd17327 11 CILYFLQ---YLDKSNISnaaVMGMKED-----LKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 102 ITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGRNVNYWQVVWYVAIVTSSLCVIAFFLM--GTGS 179
Cdd:cd17327 83 LLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 180 HLWRVAVGFGAIIALVLYLLRLKFLHESPT--WMINHYSLGQAADYIRqkyhvdiqlASNQTNDVSSQERQPSARALFQP 257
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLVIFFWLPDNPSkaWFLTEEEKELAVERLR---------ANQTGKGDQKFKWKQIKEAFKDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 258 kygkRLLLATAISTLQGMQYYAVGLYIPIIaTYIISKEKLGVLLGTAIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALV 337
Cdd:cd17327 234 ----RTWLLFLFFFCSQITNNGISNFLPLI-LKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVL 308
|
...
gi 488409712 338 LIA 340
Cdd:cd17327 309 ALV 311
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
28-134 |
3.97e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 42.25 E-value: 3.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 28 FMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPI--GALIgaIFGGVFAHRFGRKRILSISLLALVITSL 105
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLtvGTFI--LIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100
....*....|....*....|....*....
gi 488409712 106 GAALSPNLTILLLCRFLMGMAIGMDSPVA 134
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGLGPAFLLPNA 107
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
71-127 |
4.58e-04 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 42.02 E-value: 4.58e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAI 127
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFAL 102
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
36-127 |
7.32e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.99 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 36 LDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTI 115
Cdd:PRK03893 31 LDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWT 110
|
90
....*....|..
gi 488409712 116 LLLCRFLMGMAI 127
Cdd:PRK03893 111 LFIARLVIGMGM 122
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
71-204 |
1.22e-03 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 40.81 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGA-IFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISNRAQKGR 149
Cdd:cd17378 44 VGCLIGSgVLGHLADSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQ 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 488409712 150 NVNYWQVVWYVAIVtsSLCVIAFFLMGTGSHLWRVAVGFGAIIALVLYLLRLKFL 204
Cdd:cd17378 124 VGMSTFFFFVLGFM--SLPGIAYLNGSSWRVLYFWTSIPALIYCILVYLFARRLL 176
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
75-391 |
1.23e-03 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 41.24 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 75 IGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLT--------ILLLCRFLMGMAIGMDSPVAFTFIAEIS---N 143
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSpdrK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 144 RAQKGRNVNYWQVVWYVaiVTSSLCVIAFFLMGTGSHL---WRVAVGFGAIIALVLYLLRlKFLHESPTWminhyslgqa 220
Cdd:PRK10642 152 RGFMGSWLDFGSIAGFV--LGAGVVVLISTIVGEANFLdwgWRIPFFIALPLGIIGLYLR-HALEETPAF---------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 221 adyirqKYHVDIQlasNQTNDVSSQERQPSARALFQPKYGKRLLLATAISTLQGMQYYAVGLYIPIIATYIIS-KEKLGV 299
Cdd:PRK10642 219 ------QQHVDKL---EQGDREGLQDGPKVSFKEIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHySEDHGV 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 300 LLGTAIVNIAGIVGAYFGAqLTYRLGTRKLTIIG-FALVLIA-----MVMTGVFYH------LLPMILNTFLialflfgh 367
Cdd:PRK10642 290 LIIIAIMIGMLFVQPVMGL-LSDRFGRRPFVILGsVALFVLAipafiLINSNVIGLifagllMLAVILNCFT-------- 360
|
330 340
....*....|....*....|....
gi 488409712 368 sggpGTQGKTIGALsFPTYLRSQA 391
Cdd:PRK10642 361 ----GVMASTLPAM-FPTHIRYSA 379
|
|
| COG4262 |
COG4262 |
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ... |
262-437 |
1.54e-03 |
|
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];
Pssm-ID: 443404 [Multi-domain] Cd Length: 426 Bit Score: 40.62 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 262 RLLLATAISTLQGmqyyavglyipIIATYIISKEkLGVLLGTAIVNIAGIVGAY-----FGAQLTYRLGTRKLTIIGFAL 336
Cdd:COG4262 11 LLLLAVFVVGACG-----------LVYELLLGRL-ASYLLGDSVLQFSIVIGVFlfamgLGSYLSRRVADRLLRAFIRLE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 337 VLIAMV--MTGVFYHLLPMILNTFLIALFLFGHSGGPGTqgkTIGALsFPTYLR---SQATGFVEAVSRT------GSII 405
Cdd:COG4262 79 LLLALLggLSALLLFALFAFLLGALFLLALYLLVLLIGL---LIGAE-IPLLMRlleRRREELGSAVGRVyaadylGALV 154
|
170 180 190
....*....|....*....|....*....|....
gi 488409712 406 GTFIFPIILA-AVGLTNTMLILSIVPL-VGLIIT 437
Cdd:COG4262 155 GSLLFPFLLLpALGLVRTALLFGLLNAaVALVLL 188
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
277-441 |
1.66e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 40.69 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 277 YYAVG-LYIPIIATYIISKEKLGVLLGTAIVnIAGIVGAYFGAQLTYRLGTRKLTIIGF-ALVLIAMVM-TGVFYhlLPM 353
Cdd:cd17398 242 YYAIStLLNQMVLEYFPNEEVNAGWIGLTLV-IAGLVGSVVAGIWLDKTKKYKETTIIVyILSFIGMVAfTFTLD--LGS 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 354 ILNTFLIALFLFGHSGGPGTQGKTIGA-LSFPTylrSQAT--GFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVP 430
Cdd:cd17398 319 IWVVFLTAGALGFFMTGYLPVGFEFAAeLTYPE---PEGTssGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVAL 395
|
170
....*....|.
gi 488409712 431 LVGLIITSAIK 441
Cdd:cd17398 396 LLGTILTAFIK 406
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
24-140 |
2.89e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 39.91 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 24 KMLLFMILGTIFlDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVIT 103
Cdd:PRK12307 18 NALFSAWLGYVF-DGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVG 96
|
90 100 110
....*....|....*....|....*....|....*..
gi 488409712 104 SLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAE 140
Cdd:PRK12307 97 TGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVE 133
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
43-209 |
3.84e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 43 ILGTMTDQLtqqfHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFL 122
Cdd:cd06180 21 LLPLMLAEL----GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 123 MGMAigmdSPVAFTFIAEISNRAQKGRNVNYWQVVWY----VAIVTSSLCVIAFFLMGTGSH-LWRVAVGFGAIIALVLY 197
Cdd:cd06180 97 AGAA----SAFVFVFGSNLVLHHATAAGRGHLIGLLFagvgLGIALSGLLVPAGLGGGLSWRaGWLALALLSAVLLLLSF 172
|
170
....*....|..
gi 488409712 198 LLRLKFLHESPT 209
Cdd:cd06180 173 LLLRRGPSAPTE 184
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
52-141 |
4.28e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 52 TQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDS 131
Cdd:PRK15402 40 VEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIG 119
|
90
....*....|
gi 488409712 132 PVAFTFIAEI 141
Cdd:PRK15402 120 AVGYAAIQES 129
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
71-200 |
4.70e-03 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 38.96 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEISnraqkGRN 150
Cdd:cd17375 46 LGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFT-----GIK 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488409712 151 VNYWqvvwyvaivtSSLCVIAFFLMGTgshlwrvavgfgAIIALVLYLLR 200
Cdd:cd17375 121 ARTW----------ASMHVHAFFAVGI------------MVVALVGYLVR 148
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
281-444 |
4.77e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 281 GLYIPIIATYIISKEKLGVLLGT--AIVNIAGIVGAYFGAQLTYRLGTRKLTIIGFALVLIAMVMTGVFYHLLpmilnTF 358
Cdd:cd17325 13 GIIIPILPLYAESLGASVAQIGLivAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW-----QL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 359 LIALFLFGHSGGP-GTQGKTIGALSFPTYLRSQATGFVEAVSRTGSIIGTFIFPIILAAVGLTNTMLILSIVPLVGLIIT 437
Cdd:cd17325 88 LLARFLQGLASAAvWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLA 167
|
....*..
gi 488409712 438 SAIKWEP 444
Cdd:cd17325 168 LLLLPEP 174
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
51-149 |
4.80e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 51 LTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFG---RKRILS----ISLLALVITSLGAALSPNLTILLLCrFLM 123
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVitaaIAAAALLVLSLLSPGTPLWLLVLLL-ILL 303
|
90 100
....*....|....*....|....*.
gi 488409712 124 GMAIGMDSPVAFTFIAEISNRAQKGR 149
Cdd:cd17475 304 GLFAIGWNGLYLTLVAESAGPEQAGT 329
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
41-129 |
4.95e-03 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 39.02 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 41 ITILGTMTDQLTQQFHLSPTMLStVMTSLPIGALIG-AIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLC 119
Cdd:PRK09705 25 LTSVGPLLPQLRQASGMSFSVAA-LLTALPVVTMGGlALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSS 103
|
90
....*....|
gi 488409712 120 RFLMGMAIGM 129
Cdd:PRK09705 104 ALLGGVGIGI 113
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
29-141 |
5.10e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.89 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 29 MILGTIFLDAYDIT---ILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSL 105
Cdd:cd17368 224 ILLGMLLVAGSTVTfyfTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLY 303
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488409712 106 GA----ALSPNLTILLLCRFLMGMAIGMDSPVAFTFIAEI 141
Cdd:cd17368 304 PVfawlTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVEL 343
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| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-133 |
5.82e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 25 MLLFMILGTIFLDAYDITILGTMTDQLTQQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITS 104
Cdd:cd17478 195 RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFL 274
|
90 100 110
....*....|....*....|....*....|
gi 488409712 105 LGAALSP-NLTILLLcrFLMGMAIGMDSPV 133
Cdd:cd17478 275 LLFLLTPgIWSYILL--VLAGFLLFASFPV 302
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
71-129 |
8.21e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 38.32 E-value: 8.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRilsISLLALVITSLGAALSP---NLTILLLCRFLMGMAIGM 129
Cdd:cd17384 241 IGYLIGTNLFGPLAHKIGRWL---CSLLGMLLVGISLILIPlakNIYGLIIPHFGLGLGIGM 299
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
53-148 |
8.72e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409712 53 QQFHLSPTMLSTVMTSLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIGMDSP 132
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90
....*....|....*.
gi 488409712 133 VAFTFIAEISNRAQKG 148
Cdd:cd17370 307 IERAAVADLVPAELRG 322
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
71-128 |
8.94e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 38.22 E-value: 8.94e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 488409712 71 IGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMGMAIG 128
Cdd:cd17445 47 LGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALA 104
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
68-124 |
9.72e-03 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 37.88 E-value: 9.72e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 488409712 68 SLPIGALIGAIFGGVFAHRFGRKRILSISLLALVITSLGAALSPNLTILLLCRFLMG 124
Cdd:cd17373 33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEG 89
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