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Conserved domains on  [gi|488411817|ref|WP_002481202|]
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MULTISPECIES: 1-acyl-sn-glycerol-3-phosphate acyltransferase [Staphylococcus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 2.70e-46

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 151.70  E-value: 2.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   2 YKFISSILYWIIVKLSKSLKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALyPNQIHYMAKKELFYNPAFGNFLKSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  82 FPVDRENPGPS--TIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG----LVT 153
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGTERALPkgflPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488411817 154 GKAKIIFGEPIDTNALPDhlKKRHEKVDYITQELTKRTRALQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEG--EDRRELAERLRAAIEALLAELRAE 213
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 2.70e-46

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 151.70  E-value: 2.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   2 YKFISSILYWIIVKLSKSLKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALyPNQIHYMAKKELFYNPAFGNFLKSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  82 FPVDRENPGPS--TIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG----LVT 153
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGTERALPkgflPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488411817 154 GKAKIIFGEPIDTNALPDhlKKRHEKVDYITQELTKRTRALQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEG--EDRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 8-187 7.12e-43

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 142.02  E-value: 7.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   8 ILYWIIVKLskslKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALyPNQIHYMAKKELFYNPAFGNFLKSLNAFPVDRE 87
Cdd:cd07989    4 LLRLLGVRV----RVEGLENLPPKGPVIIVANHQSYLDPLVLGAAL-PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  88 NP--GPSTIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG-----LVTGKAKI 158
Cdd:cd07989   79 NGrsAREALREAIEALKEGESVVIFPEGTRSRDGEllPFKSGAFRLAKEAGVPIVPVAISGTWGSLPkgkklPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*....
gi 488411817 159 IFGEPIDtnalPDHLKKRHEKVDYITQEL 187
Cdd:cd07989  159 RIGEPIP----PEGLELAEEDRKELREKV 183
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 20-142 2.66e-37

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 125.92  E-value: 2.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   20 LKVYGRENVPQLNRYVVTCNHESYNEVIMLGmALYPNQIHYMAKKELFYNPAFGNFLKSLNAFPVDREN--PGPSTIKTP 97
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLS-AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKAA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 488411817   98 VNLLKKNKTIGMFPAGHRTSEETPL--KRGAATIAMMAKVPIVPAAY 142
Cdd:TIGR00530  83 IEVLKQGRSIGVFPEGTRSRGRDILpfKKGAFHIAIKAGVPILPVVL 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 20-142 3.70e-30

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 107.75  E-value: 3.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   20 LKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALYP--NQIHYMAKKELFYNPAFGNFLKSLNAFPVDRENPG--PSTIK 95
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGTLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 488411817   96 TPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAY 142
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGEllPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 34-144 6.16e-28

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 101.66  E-value: 6.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817    34 YVVTCNHESYNEVIMLGMALYP--NQIHYMAKKELFYNPAFGNFLKSLNAFPVDRENPGP--STIKTPVNLLKKNKTIGM 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 488411817   110 FPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEG 144
Cdd:smart00563  81 FPEGTRSRPGKllPFKKGAARLALEAGVPIVPVAIRG 117
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
11-147 5.95e-09

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 54.97  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   11 WIIVKLSKSLKVYGRENVPQL-NRYVVTCNHESYNEVIMLgMALYPNQ----IHYMAKKELFYNPafgnFLKSLNAFPVD 85
Cdd:PRK06814  432 SILFRAFYRVEVKGLENLQKAgKKAVIAANHVSFLDGPLL-AAYLPEEptfaIDTDIAKAWWVKP----FLKLAKALPVD 506

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488411817   86 RENpgPSTIKTPVNLLKKNKTIGMFPAGHRTSEETPLK--RGAATIAMMAKVPIVPAAYEGPDK 147
Cdd:PRK06814  507 PTN--PMATRTLIKEVQKGEKLVIFPEGRITVTGSLMKiyDGPGMIADKAGAMVVPVRIDGLQF 568
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 2-197 2.70e-46

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 151.70  E-value: 2.70e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   2 YKFISSILYWIIVKLSKSLKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALyPNQIHYMAKKELFYNPAFGNFLKSLNA 81
Cdd:COG0204   13 YRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAAL-PRPVRFVAKKELFKIPLLGWLLRALGA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  82 FPVDRENPGPS--TIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG----LVT 153
Cdd:COG0204   92 IPVDRSKRRAAlrALRQAVEALKAGESLVIFPEGTRSPDGRllPFKTGAARLALEAGVPIVPVAIDGTERALPkgflPRP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488411817 154 GKAKIIFGEPIDTNALPDhlKKRHEKVDYITQELTKRTRALQQE 197
Cdd:COG0204  172 GKVTVRIGPPIDPSDLEG--EDRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 8-187 7.12e-43

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 142.02  E-value: 7.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   8 ILYWIIVKLskslKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALyPNQIHYMAKKELFYNPAFGNFLKSLNAFPVDRE 87
Cdd:cd07989    4 LLRLLGVRV----RVEGLENLPPKGPVIIVANHQSYLDPLVLGAAL-PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  88 NP--GPSTIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG-----LVTGKAKI 158
Cdd:cd07989   79 NGrsAREALREAIEALKEGESVVIFPEGTRSRDGEllPFKSGAFRLAKEAGVPIVPVAISGTWGSLPkgkklPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*....
gi 488411817 159 IFGEPIDtnalPDHLKKRHEKVDYITQEL 187
Cdd:cd07989  159 RIGEPIP----PEGLELAEEDRKELREKV 183
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 20-142 2.66e-37

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 125.92  E-value: 2.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   20 LKVYGRENVPQLNRYVVTCNHESYNEVIMLGmALYPNQIHYMAKKELFYNPAFGNFLKSLNAFPVDREN--PGPSTIKTP 97
Cdd:TIGR00530   4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLS-AAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENirAIATALKAA 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 488411817   98 VNLLKKNKTIGMFPAGHRTSEETPL--KRGAATIAMMAKVPIVPAAY 142
Cdd:TIGR00530  83 IEVLKQGRSIGVFPEGTRSRGRDILpfKKGAFHIAIKAGVPILPVVL 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 20-142 3.70e-30

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 107.75  E-value: 3.70e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   20 LKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALYP--NQIHYMAKKELFYNPAFGNFLKSLNAFPVDRENPG--PSTIK 95
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKdaAGTLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 488411817   96 TPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAY 142
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGEllPFKKGAFRLAIEAGVPIVPVAI 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 34-144 6.16e-28

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 101.66  E-value: 6.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817    34 YVVTCNHESYNEVIMLGMALYP--NQIHYMAKKELFYNPAFGNFLKSLNAFPVDRENPGP--STIKTPVNLLKKNKTIGM 109
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKarAALREAVELLKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 488411817   110 FPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEG 144
Cdd:smart00563  81 FPEGTRSRPGKllPFKKGAARLALEAGVPIVPVAIRG 117
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 2-198 3.67e-20

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 83.85  E-value: 3.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   2 YKFISSILYWIIVKlskSLKVYGRENVPQLNRYVVTCNHEsyNEVI--MLGMALYPNQIHYMAKKELFYNPAFGNFLKSL 79
Cdd:cd07992    1 VRLLSRVILRIYFR---RITVVGRENVPKDGPVIFLGNHP--NALIdpLLLAATLRRPVRFLAKADLFKNPLIGWLLESF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  80 NAFPVDRENPGPSTIKTPVN----------LLKKNKTIGMFPAG--HRTSEETPLKRGAATIAMMA------KVPIVPAA 141
Cdd:cd07992   76 GAIPVYRPKDLARGGIGKISnaavfdavgeALKAGGAIGIFPEGgsHDRPRLLPLKAGAARMALEAleagqkDVKIVPVG 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488411817 142 --YEGPDKIiglvTGKAKIIFGEPIDTNALPDHLKKRHEKvdyitqelTKRTRALQQEL 198
Cdd:cd07992  156 lnYEDKSRF----RSRVLVEFGKPISVSAFEEAEASRDVE--------KKLINQLEAEL 202
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 9-187 9.01e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 77.07  E-value: 9.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   9 LYWIIVKLSKSLKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALY---PNQIHYMAKKELFYNPAFgnfLKSLNAFPVD 85
Cdd:cd06551    3 YLLLNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLErglRRDVYGLMDEELLERYPF---FTRLGAFSVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  86 RENPGP--STIKTPVNLLKK-NKTIGMFPAGHRTSEETPL---KRGAATIAMMAKVPIVPAAYEGpDKIIGLVTGKAKII 159
Cdd:cd06551   80 RDSPRSaaKSLKYVARLLSKpGSVVWIFPEGTRTRRDKRPlqfKPGVAHLAEKAGVPIVPVALRY-TFELFEQFPEIFVR 158

                        170       180
                 ....*....|....*....|....*...
gi 488411817 160 FGEPIDTNALPDHLKKRHEKVDYITQEL 187
Cdd:cd06551  159 IGPPIPYAETALGEELAAELANRLTRLL 186
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 46-152 4.60e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 66.86  E-value: 4.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  46 VIMLGMALYPNQIHYMAKKELFYNPaFGNFLKSLNAFPVDRENPGpSTIKTPVNLLKKNKTI--GMFPAGHRTSEEtPLK 123
Cdd:cd07988   37 LGLLAAFALGLKISFLGKHSLFKPP-LGPFMRWLGGIPVDRSRAG-GLVEQVVEEFRRREEFvlAIAPEGTRSKVD-KWK 113

                         90       100
                 ....*....|....*....|....*....
gi 488411817 124 RGAATIAMMAKVPIVPAAYEGPDKIIGLV 152
Cdd:cd07988  114 TGFYHIARGAGVPILLVYLDYKRKTVGIG 142
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
11-147 5.95e-09

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 54.97  E-value: 5.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   11 WIIVKLSKSLKVYGRENVPQL-NRYVVTCNHESYNEVIMLgMALYPNQ----IHYMAKKELFYNPafgnFLKSLNAFPVD 85
Cdd:PRK06814  432 SILFRAFYRVEVKGLENLQKAgKKAVIAANHVSFLDGPLL-AAYLPEEptfaIDTDIAKAWWVKP----FLKLAKALPVD 506

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488411817   86 RENpgPSTIKTPVNLLKKNKTIGMFPAGHRTSEETPLK--RGAATIAMMAKVPIVPAAYEGPDK 147
Cdd:PRK06814  507 PTN--PMATRTLIKEVQKGEKLVIFPEGRITVTGSLMKiyDGPGMIADKAGAMVVPVRIDGLQF 568
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 8-139 2.13e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 53.39  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817    8 ILYWIIVKLSKSLKVYGRENVPQLNRYVVTCNHESYNEVIMLGMAlYPNQIHYMAKKELFYNPAFGNFLKSLNAFPVDRE 87
Cdd:PRK08633  417 FLLLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQAA-SPRPIRFVMERSIYEKWYLKWFFKLFGVIPISSG 495

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488411817   88 NPgPSTIKTPVNLLKKNKTIGMFPAGH--RTSEETPLKRGAATIAMMAKVPIVP 139
Cdd:PRK08633  496 GS-KESLEFIRKALDDGEVVCIFPEGAitRNGQLNEFKRGFELIVKGTDVPIIP 548
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 22-198 2.41e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 51.90  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  22 VYGRENVPQLNRYVVTCNHESYNEVIMLGMALYPN-----QIHYMAKKELFYNPAFGNFLKSLNAFPVDRENPgpstikt 96
Cdd:cd07987   10 VRGLENIPDEGPALLVHPHGGLPIDGALLAAAFLLlfpgrLPRALADHFLFPLPGLRDLLRRLGAVPGSRENC------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  97 pVNLLKKNKTIGMFP-----AGHRTSEETPL----KRGAATIAMMAKVPIVPAAYEGPDKIIGLVTGKAK---------- 157
Cdd:cd07987   83 -VRLLREGELVLIFPggareALKSKREEYYLlwkkRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGpvgkrlfrll 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488411817 158 ---------IIFGEPIDTnalpdHLKKRHEKVDYITQELTKRTRALQQEL 198
Cdd:cd07987  162 plprrlplyPVFGEPIVV-----PRPPIPDPPDEDVEELHQKYIAALREL 206
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 4-167 2.03e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 49.34  E-value: 2.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817   4 FISSILYWIIVKLSKSLKVYGRENVPQLNRYVV-TCNHESYNEVIMLGMALYPnqIHYMAKKELFYNPAFGNFLKSLNAF 82
Cdd:PLN02901  21 FINKVWATLSTSPFYKIEVEGLENLPSPDEPAVyVSNHQSFLDIYTLFHLGRP--FKFISKTSIFLIPIIGWAMYMTGHI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  83 PVDRENPGPS--TIKTPVNLLKKNKTIGMFPAGHRTSEET--PLKRGAATIAMMAKVPIVPAAYEGPDKIIG------LV 152
Cdd:PLN02901  99 PLKRMDRRSQleCLKRCMELLKKGASVFFFPEGTRSKDGKlaAFKKGAFSVAAKTGVPVVPITLVGTGKIMPngkegiLN 178

                        170
                 ....*....|....*
gi 488411817 153 TGKAKIIFGEPIDTN 167
Cdd:PLN02901 179 PGSVKVVIHPPIEGS 193
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 26-144 8.23e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 44.93  E-value: 8.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  26 ENVPQLNRYVVTCNHE--SYNEVIMLGM--ALYPNqIHYMAKKELFYNPAFGNFLkslnaFPVD---RENPGP---STIK 95
Cdd:cd07986   16 ENIPKDGPVVIVANHPfgILDGLILADLlgSVRPD-VRILANQLLSKIPELRDLF-----IPVDpleGRAALAknrESLR 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488411817  96 TPVNLLKKNKTIGMFPAG--------HRTSEETPLKRGAATIAMMAKVPIVPAAYEG 144
Cdd:cd07986   90 EALRHLKNGGALIIFPAGrvstasppFGRVSDRPWNPFVARLARKAKAPVVPVYFSG 146
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 39-139 7.62e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 42.31  E-value: 7.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  39 NHESYNEVIMLGMALYPNQIhYMAKKELFYNPAFGNFLKSLNAFPVDREN--PGPSTIKTPVNLLKKNK-TIGMFPAGHR 115
Cdd:PRK15018  72 NHQNNYDMVTASNIVQPPTV-TVGKKSLLWIPFFGQLYWLTGNLLIDRNNrtKAHGTIAEVVNHFKKRRiSIWMFPEGTR 150

                         90       100
                 ....*....|....*....|....*.
gi 488411817 116 TSEE--TPLKRGAATIAMMAKVPIVP 139
Cdd:PRK15018 151 SRGRglLPFKTGAFHAAIAAGVPIIP 176
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 45-166 4.28e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 39.51  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  45 EVIMLGMALYPNQIHYMAKKelFYNPAFGNFLKSL----NAFPVDRENpgpsTIKTPVNLLKKNKTIGMFP---AGHRTS 117
Cdd:cd07984   33 ELAGLALALLGYPVTVVYRP--LKNPLLDRLITRGrerfGARLIPRGG----GLRELIRALKKGEIVGILPdqdPGRKGG 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488411817 118 EETPL-------KRGAATIAMMAKVPIVPA-AYEGPDkiiglvtGKAKIIFGEPIDT 166
Cdd:cd07984  107 VFVPFfgrpaatPTGPARLALKTGAPVVPAfAYRLPG-------GGYRIEFEPPLEN 156
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 10-96 1.45e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 38.36  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  10 YWIivklskslKVYGRENVPQLNRYVVtCNHESYNEVIMLGMALYPNqihYMAKKELFYNPAFGNFLKSLNAFPVDRENP 89
Cdd:cd07991   11 YVI--------KVHGKPDPPEAPRIIV-ANHTSFIDPLILFSDLFPS---IVAKKELGKLPFIGTILRALGCIFVDRSEP 78


                 ....*..
gi 488411817  90 GPSTIKT 96
Cdd:cd07991   79 KDRKKVV 85
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 20-120 8.60e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 35.68  E-value: 8.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488411817  20 LKVYGRENVPQLNRYVVTCNHESYNEVIMLGMALYPNQIH----YMAKKELFYNPAFGNFLKSLNAFPVDR-----ENpg 90
Cdd:cd07990   12 VVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLgrlkIVLKDSLKYPPLGGWGWQLGEFIFLKRkwekdEK-- 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 488411817  91 psTIKTPVNLLKKNKT---IGMFPAGHRTSEET 120
Cdd:cd07990   90 --TIKRQLKRLKDSPEpfwLLIFPEGTRFTEEK 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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