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Conserved domains on  [gi|488433627|ref|WP_002503012|]
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sensor histidine kinase [Staphylococcus epidermidis]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
103-511 4.37e-64

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 214.88  E-value: 4.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 103 ILYYDLKGSSQSFTNNYEQLDTTKMYLISKYRIDFKDDTYILKIYMSSTPLLKNIKKNSGQSALIVDSYDTVLYTNDDRF 182
Cdd:COG2972   33 ILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 183 SIGQKYQPPQFGFMNESLKLNSHHAHLIIYKDIHETIEDGIALLVVMGVVLILLVIFGYISADRMAKRQSEDIEAIVRKI 262
Cdd:COG2972  113 LLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAM 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 263 DDAKNRHLGsYEPLKKHSELEEINNYIYDLFESNEQLIQSIEQTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLIPLS- 341
Cdd:COG2972  193 KKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEd 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 342 PKVAQTVIQQLSQMLRYSLRTASHTVKLAEELSYIEQYVAIQNIRFDDMIQLYIDATEGVQHQTIGKMMLQPLVENAIKH 421
Cdd:COG2972  272 PEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEH 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 422 G--RDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLHHDvFDTTHLGLNHLHNRAMIQYGTYARLHIFSRS 499
Cdd:COG2972  352 GiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK-GEGRGIGLRNVRERLKLYYGEEYGLEIESEP 430

                        410
                 ....*....|..
gi 488433627 500 QQGTLMCYQIPL 511
Cdd:COG2972  431 GEGTTVTIRIPL 442
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
103-511 4.37e-64

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 214.88  E-value: 4.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 103 ILYYDLKGSSQSFTNNYEQLDTTKMYLISKYRIDFKDDTYILKIYMSSTPLLKNIKKNSGQSALIVDSYDTVLYTNDDRF 182
Cdd:COG2972   33 ILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 183 SIGQKYQPPQFGFMNESLKLNSHHAHLIIYKDIHETIEDGIALLVVMGVVLILLVIFGYISADRMAKRQSEDIEAIVRKI 262
Cdd:COG2972  113 LLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAM 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 263 DDAKNRHLGsYEPLKKHSELEEINNYIYDLFESNEQLIQSIEQTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLIPLS- 341
Cdd:COG2972  193 KKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEd 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 342 PKVAQTVIQQLSQMLRYSLRTASHTVKLAEELSYIEQYVAIQNIRFDDMIQLYIDATEGVQHQTIGKMMLQPLVENAIKH 421
Cdd:COG2972  272 PEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEH 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 422 G--RDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLHHDvFDTTHLGLNHLHNRAMIQYGTYARLHIFSRS 499
Cdd:COG2972  352 GiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK-GEGRGIGLRNVRERLKLYYGEEYGLEIESEP 430

                        410
                 ....*....|..
gi 488433627 500 QQGTLMCYQIPL 511
Cdd:COG2972  431 GEGTTVTIRIPL 442
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 406-510 2.45e-38

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 135.67  E-value: 2.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 406 IGKMMLQPLVENAIKHGRD----SEPLKITIRIRLtKRKLHILVHDNGIGMSPSHLEHVRQSLhhdvFDTTHLGLNHLHN 481
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQekkgKGVVKISVKKQL-KNRLHIAVEDNGIGISPKVIERVEQDE----MPGNKIGLLNVHQ 75

                         90       100
                 ....*....|....*....|....*....
gi 488433627 482 RAMIqyGTYARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16955   76 RLKL--GYGEGLHIRSRPDPGTLIAFYIP 102
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 314-391 1.85e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 90.96  E-value: 1.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488433627  314 QLKEIERQFQPHFLFNTMQTIQYLIPLSPKVAQTVIQQLSQMLRYSLRTASHTVKLAEELSYIEQYVAIQNIRFDDMI 391
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 410-511 2.27e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 57.66  E-value: 2.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627   410 MLQPLVENAIKHGRDSEplKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV-----RQSLHHDVFDTTHLGLnHLHNRAM 484
Cdd:smart00387   9 VLSNLLDNAIKYTPEGG--RITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffRTDKRSRKIGGTGLGL-SIVKKLV 85

                           90       100
                   ....*....|....*....|....*..
gi 488433627   485 IQYGtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:smart00387  86 ELHG--GEISVESEPGGGTTFTITLPL 110
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
103-511 4.37e-64

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 214.88  E-value: 4.37e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 103 ILYYDLKGSSQSFTNNYEQLDTTKMYLISKYRIDFKDDTYILKIYMSSTPLLKNIKKNSGQSALIVDSYDTVLYTNDDRF 182
Cdd:COG2972   33 ILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 183 SIGQKYQPPQFGFMNESLKLNSHHAHLIIYKDIHETIEDGIALLVVMGVVLILLVIFGYISADRMAKRQSEDIEAIVRKI 262
Cdd:COG2972  113 LLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAM 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 263 DDAKNRHLGsYEPLKKHSELEEINNYIYDLFESNEQLIQSIEQTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLIPLS- 341
Cdd:COG2972  193 KKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEd 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 342 PKVAQTVIQQLSQMLRYSLRTASHTVKLAEELSYIEQYVAIQNIRFDDMIQLYIDATEGVQHQTIGKMMLQPLVENAIKH 421
Cdd:COG2972  272 PEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEH 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 422 G--RDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLHHDvFDTTHLGLNHLHNRAMIQYGTYARLHIFSRS 499
Cdd:COG2972  352 GiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK-GEGRGIGLRNVRERLKLYYGEEYGLEIESEP 430

                        410
                 ....*....|..
gi 488433627 500 QQGTLMCYQIPL 511
Cdd:COG2972  431 GEGTTVTIRIPL 442
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
282-511 6.01e-47

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 166.97  E-value: 6.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 282 LEEINNYIYDLFESNEQLIQSIEQTERRLRDIQLKEIERQFQPHFLFNTMQTIQYLIPLSPKVAQTVIQQLSQMLRYSLR 361
Cdd:COG3275  128 LLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLY 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 362 TASH-TVKLAEELSYIEQYVAIQNIRFDDMIQLYIDATEGVQHQTIGKMMLQPLVENAIKHG--RDSEPLKITIRIRLTK 438
Cdd:COG3275  208 ESDKeLVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGisSKEGGGTISISIEVEG 287

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488433627 439 RKLHILVHDNGIGMSPSHLEHvrqslhhdvfdTTHLGLNHLHNRAMIQYGTYARLHIFSRSQQGTLMCYQIPL 511
Cdd:COG3275  288 DRLVIEVENNGVGIQPKKKKK-----------GSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPL 349
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 406-510 2.45e-38

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 135.67  E-value: 2.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 406 IGKMMLQPLVENAIKHGRD----SEPLKITIRIRLtKRKLHILVHDNGIGMSPSHLEHVRQSLhhdvFDTTHLGLNHLHN 481
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQekkgKGVVKISVKKQL-KNRLHIAVEDNGIGISPKVIERVEQDE----MPGNKIGLLNVHQ 75

                         90       100
                 ....*....|....*....|....*....
gi 488433627 482 RAMIqyGTYARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16955   76 RLKL--GYGEGLHIRSRPDPGTLIAFYIP 102
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 314-391 1.85e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 90.96  E-value: 1.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488433627  314 QLKEIERQFQPHFLFNTMQTIQYLIPLSPKVAQTVIQQLSQMLRYSLRTASHTVKLAEELSYIEQYVAIQNIRFDDMI 391
Cdd:pfam06580   2 ELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 406-510 2.34e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 69.01  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 406 IGKMMLQPLVENAIKHGRD--SEPLKITIRIRLTKRKLHILVHDNGIGMSPShlehVRQSLHHDVFDTTHLGLNHLHNRA 483
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSplTDKGVVTISALKEDNHVMIEVEDNGRGIDPK----VLNILGKKPKEGNGIGLYNVHQRL 76

                         90       100
                 ....*....|....*....|....*..
gi 488433627 484 MIQYGTYARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16924   77 ILLFGEDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 410-511 2.27e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 57.66  E-value: 2.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627   410 MLQPLVENAIKHGRDSEplKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV-----RQSLHHDVFDTTHLGLnHLHNRAM 484
Cdd:smart00387   9 VLSNLLDNAIKYTPEGG--RITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffRTDKRSRKIGGTGLGL-SIVKKLV 85

                           90       100
                   ....*....|....*....|....*..
gi 488433627   485 IQYGtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:smart00387  86 ELHG--GEISVESEPGGGTTFTITLPL 110
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 411-510 4.52e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 56.66  E-value: 4.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 411 LQPLVENAIKH--GRDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLHHDVfDTTHLGLNHLHNRAMIQYG 488
Cdd:cd16957    6 LQVLVENAIRHafPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE-KGTGTALENLNRRLIGLFG 84

                         90       100
                 ....*....|....*....|..
gi 488433627 489 TYARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16957   85 SEACLHIESEVHGGTEVWFVIP 106
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 411-510 2.11e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 54.75  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 411 LQPLVENAIKHGRDSEPL--KITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLhhdvfdTTHLGLNHLHNRAMIQYG 488
Cdd:cd16956    6 LQPIVENAVKHGLSGLLDggRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRS------SNGLGLNLVDKRLRQAFG 79

                         90       100
                 ....*....|....*....|..
gi 488433627 489 TYARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16956   80 NDYGLDIECAPGEGTRITIRLP 101
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
414-511 3.37e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 58.38  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 414 LVENAIKHGRDSEPlkITIRIRLTKRKLHILVHDNGIGMSPSHLEHV----RQSLHHDVFDTTHLGLN------HLHNra 483
Cdd:COG0642  231 LLSNAIKYTPEGGT--VTVSVRREGDRVRISVEDTGPGIPPEDLERIfepfFRTDPSRRGGGTGLGLAivkrivELHG-- 306

                         90       100
                 ....*....|....*....|....*...
gi 488433627 484 miqygtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:COG0642  307 -------GTIEVESEPGKGTTFTVTLPL 327
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 410-511 8.50e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 53.14  E-value: 8.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627  410 MLQPLVENAIKHGRDSEPLKITIRirlTKRKLHILVHDNGIGMSPSHLEHVrqslhHDVFDT--------THLGLnHLHN 481
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLS---EGGELTLTVEDNGIGIPPEDLPRI-----FEPFSTadkrggggTGLGL-SIVR 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 488433627  482 RAMIQYGtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:pfam02518  80 KLVELLG--GTITVESEPGGGTTVTLTLPL 107
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
331-511 1.29e-08

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 55.78  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 331 MQTIQYLIPLSPKVAQTVIQQLSQMLR---YSLRTASHT--------VKLAEEL-SYIEQYVAIQNIRfddmIQLYIDAT 398
Cdd:COG4585   76 LEAARRLLDADPEAAREELEEIRELARealAELRRLVRGlrppalddLGLAAALeELAERLLRAAGIR----VELDVDGD 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 399 EGVQHQTIGK---MMLQPLVENAIKHGRDSEplkITIRIRLTKRKLHILVHDNGIGMSPshlehvrqslhhDVFDTTHLG 475
Cdd:COG4585  152 PDRLPPEVELalyRIVQEALTNALKHAGATR---VTVTLEVDDGELTLTVRDDGVGFDP------------EAAPGGGLG 216

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 488433627 476 LNHLHNRA-MIQygtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:COG4585  217 LRGMRERAeALG----GTLTIGSAPGGGTRVRATLPL 249
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 385-476 2.38e-08

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 56.33  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 385 IRFDDMIQLYIDATEGVQhqtigkmMLQPLVENAIKHGRDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVR--- 461
Cdd:COG4251  380 IEVGPLPTVRGDPTLLRQ-------VFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFeif 452

                         90
                 ....*....|....*.
gi 488433627 462 QSLH-HDVFDTTHLGL 476
Cdd:COG4251  453 QRLHsRDEYEGTGIGL 468
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
414-511 3.34e-08

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 54.53  E-value: 3.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 414 LVENAIKHGRDSEPlkITIRIRLTKRKLHILVHDNGIGMSPSHLEHV----RQSLHHDVFDTTHLGLN------HLHNra 483
Cdd:COG2205  140 LLDNAIKYSPPGGT--ITISARREGDGVRISVSDNGPGIPEEELERIferfYRGDNSRGEGGTGLGLAivkrivEAHG-- 215

                         90       100
                 ....*....|....*....|....*...
gi 488433627 484 miqygtyARLHIFSRSQQGTLMCYQIPL 511
Cdd:COG2205  216 -------GTIWVESEPGGGTTFTVTLPL 236
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
414-460 3.99e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 52.25  E-value: 3.99e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488433627 414 LVENAIKHGRDSEplKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV 460
Cdd:COG5002  289 LLDNAIKYTPEGG--TITVSLREEDDQVRISVRDTGIGIPEEDLPRI 333
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
414-458 1.20e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 47.60  E-value: 1.20e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488433627 414 LVENAIKHGRDSEPLK-ITIRIRLTKRKLHILVHDNGIGMSPSHLE 458
Cdd:COG2172   42 AVTNAVRHAYGGDPDGpVEVELELDPDGLEIEVRDEGPGFDPEDLP 87
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 165-464 4.42e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.13  E-value: 4.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 165 ALIVDSYDTVLYTNDDRFSIGQKYQPPQFGFMNESLKLNSHHAHLIIYKDIHETIEDGIALLVVMGVVLILLVIFGYISA 244
Cdd:COG3920  181 LAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 245 DRMAKRQSEDIEAIVRKIDDAKNRHLGSYEPLKKHSEL-EEI-----NNYiydlfesneQLIQSI-EQTERRLRDIQLKE 317
Cdd:COG3920  261 LLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLlRELhhrvkNNL---------QVVSSLlRLQARRADDPEARE 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 318 IERQFQphflfNTMQTIqyliplspkvAQtVIQQLSQmlrySLRTASHTVK--LAEELSYIEQYVAIQNIRFD---DMIQ 392
Cdd:COG3920  332 ALEESQ-----NRIQAL----------AL-VHELLYQ----SEDWEGVDLRdyLRELLEPLRDSYGGRGIRIEldgPDVE 391

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488433627 393 LYIDATegvqhQTIGkMMLQPLVENAIKHG-RDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSL 464
Cdd:COG3920  392 LPADAA-----VPLG-LILNELVTNALKHAfLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARKGL 458
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 409-510 1.42e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 43.85  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 409 MMLQPLVENAIKHGRDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV---RQSLH-HDVFDTTHLGLNhLHNRAM 484
Cdd:cd16921    3 QVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVfgiFQRLHsREEYEGTGVGLA-IVRKII 81

                         90       100
                 ....*....|....*....|....*.
gi 488433627 485 IQYGtyARLHIFSRSQQGTLMCYQIP 510
Cdd:cd16921   82 ERHG--GRIWLESEPGEGTTFYFTLP 105
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 209-460 1.18e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 44.45  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 209 LIIYKDIHETIEDGIALLVVMGVVLILLVIFGYISADRMAKRQSEDIEAIVRKIDDAKNRHLGSyeplKKHSELEEINNY 288
Cdd:COG3290   73 LKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLET----GERDEEILLNGR 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 289 IYDL----FESNEQLIQSI----EQTERRLRDIQLKEIERQF-----QPHFLFNTMQTIQYLIPL-SPKVAQTVIQQLSQ 354
Cdd:COG3290  149 VLVVnrvpIRDDGRVVGAVatfrDRTELERLEEELEGVKELAealraQRHDFRNHLHTISGLLQLgEYDEALEYIDEISE 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488433627 355 MLRYSLRTASHTVK---LAEELSYIEQYVAIQNIRFDDMIQLYIDATEGVQHQ--TIgkmmLQPLVENAIKH--GRDSEP 427
Cdd:COG3290  229 ELQELIDSLLSRIGnpvLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDlvTI----LGNLLDNAIEAveKLPEEE 304

                        250       260       270
                 ....*....|....*....|....*....|...
gi 488433627 428 LKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV 460
Cdd:COG3290  305 RRVELSIRDDGDELVIEVEDSGPGIPEELLEKI 337
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 414-454 1.19e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 41.10  E-value: 1.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 488433627 414 LVENAIKHG-RDSEPLKITIRIRLTKRKLHILVHDNGIGMSP 454
Cdd:cd16936    8 AVTNAVRHAyRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDP 49
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 414-460 3.39e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 42.86  E-value: 3.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488433627 414 LVENAIkHG-RDSEPLKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV 460
Cdd:COG4191  264 LLINAI-DAmEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 414-460 5.31e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 42.26  E-value: 5.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488433627 414 LVENAIKHGRDSEplKITIRIRLTKRKLHILVHDNGIGMSPSHLEHV 460
Cdd:COG5000  325 LLKNAIEAIEEGG--EIEVSTRREDGRVRIEVSDNGPGIPEEVLERI 369
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 414-460 5.32e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 41.27  E-value: 5.32e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488433627 414 LVENAIkhgrDSEPLKITIRIRLTKRKLhILVHDNGIGMSPSHLEHV 460
Cdd:cd16926   21 LVENSI----DAGATRIDVEIEEGGLKL-IRVTDNGSGISREDLELA 62
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 409-452 5.68e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 40.09  E-value: 5.68e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 488433627 409 MMLQPLVENAIKHG-RDSEPLKITIRIRLTKRKLHILVHDNGIGM 452
Cdd:cd16951   42 LVVNELLQNALKHAfSDREGGTITIRSVVDGDYLRITVIDDGVGL 86
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 414-457 8.68e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 39.11  E-value: 8.68e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 488433627 414 LVENAIKHGRDSEplKITIRIRLTKRKLHILVHDNGIGMSPSHL 457
Cdd:cd16952    8 LVSNAVKYTPPSD--TITVRWSQEESGARLSVEDTGPGIPPEHI 49
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
417-476 3.08e-03

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 37.65  E-value: 3.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488433627  417 NAIKHGRDSEPLK-ITIRIRLTKRKLHILVHDNGIGMSPSHLEHVRQSLHHDVFDTTHLGL 476
Cdd:pfam13581  42 NAVEHAYREGPEGpVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEGGRGL 102
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 412-454 5.18e-03

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 39.22  E-value: 5.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 488433627 412 QPLVENAIKHGRDSEplkITIRIRLTKRKLHILVHDNGIGMSP 454
Cdd:COG3851  406 QEALTNILKHAEASQ---IRISLSQDKRLLSLEIRDDGIGLPP 445
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 414-460 5.24e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 36.70  E-value: 5.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488433627 414 LVENAIK---HGRdseplkITIRIRLTKR-----KLHILVHDNGIGMSPSHLEHV 460
Cdd:cd16922    8 LLGNAIKfteEGE------VTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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