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Conserved domains on  [gi|488473478|ref|WP_002517148|]
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MULTISPECIES: DoxX family protein [Cutibacterium]

Protein Classification

DoxX family protein( domain architecture ID 10006227)

DoxX family protein, an inner membrane protein, similar to Bacillus subtilis putative oxidoreductases MhqP and CatD, and Escherichia coli inner membrane proteins YphA and YqjF

Gene Ontology:  GO:0005886
PubMed:  15306018|26067605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DoxX COG2259
Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];
121-251 1.78e-21

Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];


:

Pssm-ID: 441860  Cd Length: 134  Bit Score: 87.19  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478 121 TTDKVMASLGLFLFRLIVGGILGVHGFQHLAQRDLTLRAVQALPLPsgYAQSGVWVLGICECIAAVCIILGLFTRVAGAG 200
Cdd:COG2259    1 SLLSTLADLGLLLLRLLLGLLFLAHGLQKLFGFDGTAGFFASLGLP--LPALLAYLAGLAELVGGLLLILGLFTRLAALL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488473478 201 IIAIMVLSlTFIFWGSFAIFKTMGFkgELELLLAACGVLLLFLGAGGWSID 251
Cdd:COG2259   79 LAGFMLVA-IFVVHLPNGFWAMGGG--EKNLLLAGGLLALALLGPGRYSLD 126
 
Name Accession Description Interval E-value
DoxX COG2259
Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];
121-251 1.78e-21

Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];


Pssm-ID: 441860  Cd Length: 134  Bit Score: 87.19  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478 121 TTDKVMASLGLFLFRLIVGGILGVHGFQHLAQRDLTLRAVQALPLPsgYAQSGVWVLGICECIAAVCIILGLFTRVAGAG 200
Cdd:COG2259    1 SLLSTLADLGLLLLRLLLGLLFLAHGLQKLFGFDGTAGFFASLGLP--LPALLAYLAGLAELVGGLLLILGLFTRLAALL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488473478 201 IIAIMVLSlTFIFWGSFAIFKTMGFkgELELLLAACGVLLLFLGAGGWSID 251
Cdd:COG2259   79 LAGFMLVA-IFVVHLPNGFWAMGGG--EKNLLLAGGLLALALLGPGRYSLD 126
DoxX pfam07681
DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function ...
 130-215 2.89e-06

DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.


Pssm-ID: 429591  Cd Length: 84  Bit Score: 44.48  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478  130 GLFLFRLIVGGILGVHGFQHLAQR-DLTLRAVQALPLPSGYAQsgVWVLGICECIAAVCIILGLFTRVAGAGIIAIMVLS 208
Cdd:pfam07681   1 GLLLLRLALGVLFIAHGLQKLFGGfAGTAGYFASLGLPPPALL--AYLAILAELVGGLLLLLGLLTRLAALLLAVFMLVA 78


                  ....*..
gi 488473478  209 lTFIFWG 215
Cdd:pfam07681  79 -IFLVHA 84
HTTM smart00752
Horizontally Transferred TransMembrane Domain; Sequence analysis of vitamin K dependent ...
 127-251 1.27e-03

Horizontally Transferred TransMembrane Domain; Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.


Pssm-ID: 214802  Cd Length: 271  Bit Score: 39.23  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478   127 ASLGLFLFRLIVGGILGVH-GFQHLAQRDLTLRAVQALPLPSGYAQSGVWVLGICECIAAV---CIILGLFTRVAGagii 202
Cdd:smart00752  18 LLMLLDILRERGLSDLDLRyGDPLFFCRLAFPLFDQMSPLPFHMLSDSLDWMYLLYALMIVgalLLLLGYRTRLSS---- 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 488473478   203 aimVLSLtFIFWGSFAIFKTMGFKGELELLLaaCGVLLLFLGAGG-WSID 251
Cdd:smart00752  94 ---VLFW-LLVWSIQLRDKTVWNGGDHSYLV--GLFLLLFLPAGRyWSID 137
 
Name Accession Description Interval E-value
DoxX COG2259
Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];
121-251 1.78e-21

Uncharacterized membrane protein YphA, DoxX/SURF4 family [Function unknown];


Pssm-ID: 441860  Cd Length: 134  Bit Score: 87.19  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478 121 TTDKVMASLGLFLFRLIVGGILGVHGFQHLAQRDLTLRAVQALPLPsgYAQSGVWVLGICECIAAVCIILGLFTRVAGAG 200
Cdd:COG2259    1 SLLSTLADLGLLLLRLLLGLLFLAHGLQKLFGFDGTAGFFASLGLP--LPALLAYLAGLAELVGGLLLILGLFTRLAALL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488473478 201 IIAIMVLSlTFIFWGSFAIFKTMGFkgELELLLAACGVLLLFLGAGGWSID 251
Cdd:COG2259   79 LAGFMLVA-IFVVHLPNGFWAMGGG--EKNLLLAGGLLALALLGPGRYSLD 126
DoxX pfam07681
DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function ...
 130-215 2.89e-06

DoxX; These proteins appear to have some sequence similarity with pfam04173 but their function is unknown.


Pssm-ID: 429591  Cd Length: 84  Bit Score: 44.48  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478  130 GLFLFRLIVGGILGVHGFQHLAQR-DLTLRAVQALPLPSGYAQsgVWVLGICECIAAVCIILGLFTRVAGAGIIAIMVLS 208
Cdd:pfam07681   1 GLLLLRLALGVLFIAHGLQKLFGGfAGTAGYFASLGLPPPALL--AYLAILAELVGGLLLLLGLLTRLAALLLAVFMLVA 78


                  ....*..
gi 488473478  209 lTFIFWG 215
Cdd:pfam07681  79 -IFLVHA 84
LptF_LptG pfam03739
Lipopolysaccharide export system permease LptF/LptG; Members of this family are predicted ...
 188-248 7.57e-04

Lipopolysaccharide export system permease LptF/LptG; Members of this family are predicted integral membrane proteins of about 350 amino acids long and containing about 6 trans-membrane regions. characterized members include LptF and LptG, two homologous tandem-encoded permeases of an export ATP transporter for lipopolysaccharide (LPS) assembly in most Gram-negative bacteria.


Pssm-ID: 427477  Cd Length: 352  Bit Score: 40.34  E-value: 7.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488473478  188 IILGLFTRVAGAGIIAIMVLSLTFIFWGSFAIFKTMGFKGELELLLAACGVLLLFLGAGGW 248
Cdd:pfam03739 288 LPLGLSSRRSGRGAGLLIGILLGFLYYVLLSLGKALGENGALPPILAAWLPNLLFLLLGLW 348
LptF COG0795
Lipopolysaccharide export LptBFGC system, permease protein LptF [Cell wall/membrane/envelope ...
 187-248 1.15e-03

Lipopolysaccharide export LptBFGC system, permease protein LptF [Cell wall/membrane/envelope biogenesis, Cell motility];


Pssm-ID: 440558  Cd Length: 357  Bit Score: 39.89  E-value: 1.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478 187 CIILGL--------FTRVAGAGIIAIMVLSLTFIFWGSFAIFKTMGFKGELELLLAACGVLLLFLGAGGW 248
Cdd:COG0795  283 ALVMALlavplslrPPRSGGRGLRLLIGILLGFLYYLLLSLAGSLGESGKLPPLLAAWLPNLLFLLLGLY 352
HTTM smart00752
Horizontally Transferred TransMembrane Domain; Sequence analysis of vitamin K dependent ...
 127-251 1.27e-03

Horizontally Transferred TransMembrane Domain; Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.


Pssm-ID: 214802  Cd Length: 271  Bit Score: 39.23  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488473478   127 ASLGLFLFRLIVGGILGVH-GFQHLAQRDLTLRAVQALPLPSGYAQSGVWVLGICECIAAV---CIILGLFTRVAGagii 202
Cdd:smart00752  18 LLMLLDILRERGLSDLDLRyGDPLFFCRLAFPLFDQMSPLPFHMLSDSLDWMYLLYALMIVgalLLLLGYRTRLSS---- 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 488473478   203 aimVLSLtFIFWGSFAIFKTMGFKGELELLLaaCGVLLLFLGAGG-WSID 251
Cdd:smart00752  94 ---VLFW-LLVWSIQLRDKTVWNGGDHSYLV--GLFLLLFLPAGRyWSID 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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