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Conserved domains on  [gi|488505988|ref|WP_002549427|]
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hemolysin III family protein [Cutibacterium namnetense]

Protein Classification

PAQR family membrane homeostasis protein( domain architecture ID 10003362)

PAQR family membrane homeostasis protein such as TrhA (transmembrane homeostasis protein A), a plasma membrane protein found in both Escherichia coli and Bacillus subtilis, that belongs to the PAQR family, named for eukaryotic Progestin and AdipoQ Receptors. PAQR family proteins in bacteria originally were named for a family member from Bacillus cereus that was named hemolysin III

Gene Ontology:  GO:0019835
TCDB:  1.C.113

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
19-223 9.59e-63

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 440883  Cd Length: 213  Bit Score: 194.59  E-value: 9.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  19 PRLRGWVHTVMAPLILLAGVGLMIATPAWGN---RFAVGVWMLTGFELFGNSAVYHRVSWGaKTKDVLRRIDHANVAVFI 95
Cdd:COG1272   12 EIANAITHGIGALLAIAGLVVLIVLAALSGDawaIVSFSIYGASLILLYLASTLYHSLPSP-RAKRVLRRLDHSAIYLLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  96 AGTYTPLAVALTAGASRMALLSIIWICALLGVAFRFVWNGVPRWASTVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGG 175
Cdd:COG1272   91 AGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPAGLWLLLAGG 170
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488505988 176 VFYSVGAIAYARQKpnpsltWFGFHEVFHSCTAVAAMCHAVAIGLAVI 223
Cdd:COG1272  171 LLYTVGAVFYALKR------LPGFHEIWHLFVLAGSACHFVAILLYVL 212
 
Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
19-223 9.59e-63

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 194.59  E-value: 9.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  19 PRLRGWVHTVMAPLILLAGVGLMIATPAWGN---RFAVGVWMLTGFELFGNSAVYHRVSWGaKTKDVLRRIDHANVAVFI 95
Cdd:COG1272   12 EIANAITHGIGALLAIAGLVVLIVLAALSGDawaIVSFSIYGASLILLYLASTLYHSLPSP-RAKRVLRRLDHSAIYLLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  96 AGTYTPLAVALTAGASRMALLSIIWICALLGVAFRFVWNGVPRWASTVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGG 175
Cdd:COG1272   91 AGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPAGLWLLLAGG 170
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488505988 176 VFYSVGAIAYARQKpnpsltWFGFHEVFHSCTAVAAMCHAVAIGLAVI 223
Cdd:COG1272  171 LLYTVGAVFYALKR------LPGFHEIWHLFVLAGSACHFVAILLYVL 212
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
19-222 1.86e-42

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 142.46  E-value: 1.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   19 PRLRGWVHTVMAPLILLAGVGLMI-ATPAWGNRFAVGVWMLTG--FELFGNSAVYHRVSWGAKTKDVLRRIDHANVAVFI 95
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIySWDHGGAVAVLGFSIYGIslILLFLVSTLYHSIPKGSKAKNWLRKIDHSMIYVLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   96 AGTYTPLAVALTAGASRMALLSIIWICALLGVAFRFVWNGVPRWASTVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGG 175
Cdd:TIGR01065  82 AGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAAGG 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 488505988  176 VFYSVGAIAYARQKPNPsltwFGFHEVFHSCTAVAAMCHAVAIGLAV 222
Cdd:TIGR01065 162 LLYTVGAIFYALKWPIP----FTYHAIWHLFVLGASACHFVAILFYV 204
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
16-214 1.07e-38

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 133.16  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   16 LPTPRLRGWVHTVMAPLILLAGVGLMIATPAWGN---RFAVGVWMLTGFELFGNSAVYHRVSWGA-KTKDVLRRIDHANV 91
Cdd:pfam03006   3 IHNETLNIWTHLLGAILFIALLIFLLALATIDSQlsaVLPFLIFLLSACLCLGCSALYHTFSCHSeKVRKLFRKLDYSGI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   92 AVFIAGTYTPLAVAL--TAGASRMALLSIIWICALLGVAFRFVW---NGVPRWASTVLYVVMGWTALWWLPQFWRTGGPA 166
Cdd:pfam03006  83 FLLIAGSYTPVIYYAfyCAPKLGTIYLSFIWALAILGIISKLLWcfsKPAPRWLRTAVYILMGWSGIIPIAHRALALGGA 162
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488505988  167 V------VTLILIGGVFYSVGAIAYA-----RQKPNPSLTWFGFHEVFHSCTAVAAMCH 214
Cdd:pfam03006 163 GealeiaLVLLVLGGVLYIIGAVFYAlrvpeRLFPGKFDIVGGSHQIFHVFVVLAALCH 221
PRK15087 PRK15087
hemolysin; Provisional
63-222 3.71e-14

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 68.58  E-value: 3.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  63 LFGNSAVYHRVSwGAKTKDVLRRIDHANVAVFIAGTYTP-LAVALTAGASRmALLSIIWICALLGVAFRFVWNGVPRWAS 141
Cdd:PRK15087  64 LFLASTLYHAIP-HQRAKRWLKKFDHCAIYLLIAGTYTPfLLVGLDSPLAR-GLMIVIWSLALLGILFKLAFAHRFKVLS 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988 142 TVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGGVFYSVGAIAY-ARQKPNPSLTWFGFheVFHSCtavaaMCHAVAIGL 220
Cdd:PRK15087 142 LVTYLAMGWLSLIVIYQLAIKLAIGGVTLLAVGGVVYSLGVIFYvCKRIPYNHAIWHGF--VLGGS-----VCHFLAIYL 214

                 ..
gi 488505988 221 AV 222
Cdd:PRK15087 215 YV 216
 
Name Accession Description Interval E-value
YqfA COG1272
Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular ...
19-223 9.59e-63

Predicted membrane channel-forming protein YqfA, hemolysin III family [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440883  Cd Length: 213  Bit Score: 194.59  E-value: 9.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  19 PRLRGWVHTVMAPLILLAGVGLMIATPAWGN---RFAVGVWMLTGFELFGNSAVYHRVSWGaKTKDVLRRIDHANVAVFI 95
Cdd:COG1272   12 EIANAITHGIGALLAIAGLVVLIVLAALSGDawaIVSFSIYGASLILLYLASTLYHSLPSP-RAKRVLRRLDHSAIYLLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  96 AGTYTPLAVALTAGASRMALLSIIWICALLGVAFRFVWNGVPRWASTVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGG 175
Cdd:COG1272   91 AGTYTPFALIALRGPWGWTLLGIVWGLALLGIVLKLFFPGRPRWLSTLLYLAMGWLAVFAIPPLLAALPPAGLWLLLAGG 170
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488505988 176 VFYSVGAIAYARQKpnpsltWFGFHEVFHSCTAVAAMCHAVAIGLAVI 223
Cdd:COG1272  171 LLYTVGAVFYALKR------LPGFHEIWHLFVLAGSACHFVAILLYVL 212
hlyIII TIGR01065
channel protein, hemolysin III family; This family includes proteins from pathogenic and ...
19-222 1.86e-42

channel protein, hemolysin III family; This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.


Pssm-ID: 273425  Cd Length: 204  Bit Score: 142.46  E-value: 1.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   19 PRLRGWVHTVMAPLILLAGVGLMI-ATPAWGNRFAVGVWMLTG--FELFGNSAVYHRVSWGAKTKDVLRRIDHANVAVFI 95
Cdd:TIGR01065   2 EIANAITHGIGAVLSIIALALLVIySWDHGGAVAVLGFSIYGIslILLFLVSTLYHSIPKGSKAKNWLRKIDHSMIYVLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   96 AGTYTPLAVALTAGASRMALLSIIWICALLGVAFRFVWNGVPRWASTVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGG 175
Cdd:TIGR01065  82 AGTYTPFLLLALPGPLGWTVLWIIWGLAIGGIIYKLFFHKRPRWLSLFLYLIMGWLVVLVIKPLYHNLPGAGFSLLAAGG 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 488505988  176 VFYSVGAIAYARQKPNPsltwFGFHEVFHSCTAVAAMCHAVAIGLAV 222
Cdd:TIGR01065 162 LLYTVGAIFYALKWPIP----FTYHAIWHLFVLGASACHFVAILFYV 204
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
16-214 1.07e-38

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 133.16  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   16 LPTPRLRGWVHTVMAPLILLAGVGLMIATPAWGN---RFAVGVWMLTGFELFGNSAVYHRVSWGA-KTKDVLRRIDHANV 91
Cdd:pfam03006   3 IHNETLNIWTHLLGAILFIALLIFLLALATIDSQlsaVLPFLIFLLSACLCLGCSALYHTFSCHSeKVRKLFRKLDYSGI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988   92 AVFIAGTYTPLAVAL--TAGASRMALLSIIWICALLGVAFRFVW---NGVPRWASTVLYVVMGWTALWWLPQFWRTGGPA 166
Cdd:pfam03006  83 FLLIAGSYTPVIYYAfyCAPKLGTIYLSFIWALAILGIISKLLWcfsKPAPRWLRTAVYILMGWSGIIPIAHRALALGGA 162
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488505988  167 V------VTLILIGGVFYSVGAIAYA-----RQKPNPSLTWFGFHEVFHSCTAVAAMCH 214
Cdd:pfam03006 163 GealeiaLVLLVLGGVLYIIGAVFYAlrvpeRLFPGKFDIVGGSHQIFHVFVVLAALCH 221
PRK15087 PRK15087
hemolysin; Provisional
63-222 3.71e-14

hemolysin; Provisional


Pssm-ID: 185044  Cd Length: 219  Bit Score: 68.58  E-value: 3.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988  63 LFGNSAVYHRVSwGAKTKDVLRRIDHANVAVFIAGTYTP-LAVALTAGASRmALLSIIWICALLGVAFRFVWNGVPRWAS 141
Cdd:PRK15087  64 LFLASTLYHAIP-HQRAKRWLKKFDHCAIYLLIAGTYTPfLLVGLDSPLAR-GLMIVIWSLALLGILFKLAFAHRFKVLS 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488505988 142 TVLYVVMGWTALWWLPQFWRTGGPAVVTLILIGGVFYSVGAIAY-ARQKPNPSLTWFGFheVFHSCtavaaMCHAVAIGL 220
Cdd:PRK15087 142 LVTYLAMGWLSLIVIYQLAIKLAIGGVTLLAVGGVVYSLGVIFYvCKRIPYNHAIWHGF--VLGGS-----VCHFLAIYL 214

                 ..
gi 488505988 221 AV 222
Cdd:PRK15087 215 YV 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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