|
Name |
Accession |
Description |
Interval |
E-value |
| cysM |
PRK11761 |
cysteine synthase CysM; |
3-298 |
0e+00 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 645.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 3 LQYQTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAM 82
Cdd:PRK11761 1 MAYPTLEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTLIEATSGNTGIALAM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 83 AAAIKGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAEGRGKVLDQFANGDNPEAHYTSTGPEI 162
Cdd:PRK11761 81 IAAIKGYRMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAEGEGKVLDQFANPDNPLAHYETTGPEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 163 WRQTGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHEYLPKIYQSDRVDRIIDMGQTEAE 242
Cdd:PRK11761 161 WRQTEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEEGSSIPGIRRWPEEYLPKIFDASRVDRVLDVSQQEAE 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 488617769 243 DTMRRLAREEGIFCGVSSGGSVAGALRISREVENAVIVAIICDRGDRYLSTGIYDS 298
Cdd:PRK11761 241 NTMRRLAREEGIFCGVSSGGAVAAALRIARENPNAVIVAIICDRGDRYLSTGVFPA 296
|
|
| cysM |
TIGR01138 |
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ... |
7-296 |
0e+00 |
|
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]
Pssm-ID: 130208 [Multi-domain] Cd Length: 290 Bit Score: 511.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 7 TIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAI 86
Cdd:TIGR01138 1 TIEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 87 KGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAEGRGKVLDQFANGDNPEAHYTSTGPEIWRQT 166
Cdd:TIGR01138 81 KGYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGKLLDQFNNPDNPYAHYTSTGPEIWQQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 167 GGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHEYLPKIYQSDRVDRIIDMGQTEAEDTMR 246
Cdd:TIGR01138 161 GGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEEGSSIPGIRRWPTEYLPGIFDASLVDRVLDIHQRDAENTMR 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 488617769 247 RLAREEGIFCGVSSGGSVAGALRISREVENAVIVAIICDRGDRYLSTGIY 296
Cdd:TIGR01138 241 ELAVREGIFCGVSSGGAVAAALRLARELPDAVVVAIICDRGDRYLSTGVF 290
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
5-293 |
8.43e-164 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 457.20 E-value: 8.43e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAA 84
Cdd:COG0031 4 YDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAMVA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 85 AIKGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAE-GRGKVLDQFANGDNPEAHYTSTGPEIW 163
Cdd:COG0031 84 AAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAEtPGAFWPNQFENPANPEAHYETTGPEIW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 164 RQTGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPG-------IRRWPHEYLPKIYQSDRVDRIIDM 236
Cdd:COG0031 164 EQTDGKVDAFVAGVGTGGTITGVGRYLKERNPDIKIVAVEPEGSPLLSGgepgphkIEGIGAGFVPKILDPSLIDEVITV 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 488617769 237 GQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLST 293
Cdd:COG0031 244 SDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLgPGKTIVTILPDSGERYLST 301
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
8-296 |
2.51e-162 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 453.28 E-value: 2.51e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAIK 87
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTIIEATSGNTGIALAMVAAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 88 GYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAE-GRGKVLDQFANGDNPEAHYTSTGPEIWRQT 166
Cdd:TIGR01136 81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAEtNKYVMLDQFENPANPEAHYKTTGPEIWRDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 167 GGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPG-------IRRWPHEYLPKIYQSDRVDRIIDMGQT 239
Cdd:TIGR01136 161 DGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGgepgphkIQGIGAGFIPKILDLSLIDEVITVSDE 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 488617769 240 EAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVEN--AVIVAIICDRGDRYLSTGIY 296
Cdd:TIGR01136 241 DAIETARRLAREEGILVGISSGAAVAAALKLAKRLENadKVIVAILPDTGERYLSTGLF 299
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
13-292 |
4.26e-136 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 386.48 E-value: 4.26e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAIKGYRMI 92
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 93 LIMPDNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAERMQAEGRGKV-LDQFANGDNPEAHYTSTGPEIWRQTGGT 169
Cdd:cd01561 81 IVMPETMSEEKRKLLRALGAEVILTpeAEADGMKGAIAKARELAAETPNAFwLNQFENPANPEAHYETTAPEIWEQLDGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 170 VTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPME----------GASIPGIRRWpheYLPKIYQSDRVDRIIDMGQT 239
Cdd:cd01561 161 VDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGsvlfsggppgPHKIEGIGAG---FIPENLDRSLIDEVVRVSDE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 488617769 240 EAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLS 292
Cdd:cd01561 238 EAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLgPGKTIVTILPDSGERYLS 291
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
8-296 |
5.36e-114 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 330.87 E-value: 5.36e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNtLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAIK 87
Cdd:TIGR01139 1 ISELIGNTPLVRLNRIEGCNAN-VFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 88 GYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAE--GRGKVLDQFANGDNPEAHYTSTGPEIWRQ 165
Cdd:TIGR01139 80 GYKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAAStpNSYFMLQQFENPANPEIHRKTTGPEIWRD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 166 TGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHE-------YLPKIYQSDRVDRIIDMGQ 238
Cdd:TIGR01139 160 TDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKiqgigagFIPKNLNRSVIDEVITVSD 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 488617769 239 TEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVE-NAVIVAIICDRGDRYLSTGIY 296
Cdd:TIGR01139 240 EEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEpDKLIVVILPSTGERYLSTPLF 298
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
5-293 |
8.32e-96 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 285.60 E-value: 8.32e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAA 84
Cdd:PRK10717 4 FEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLALVA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 85 AIKGYRMILIMPDNSSAERKAAMTAYGAELISV------SKDEGMEGARDLAERMQAEGRGKVL--DQFANGDNPEAHYT 156
Cdd:PRK10717 84 AARGYKTVIVMPETQSQEKKDLLRALGAELVLVpaapyaNPNNYVKGAGRLAEELVASEPNGAIwaNQFDNPANREAHYE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 157 STGPEIWRQTGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPM---------------EGASIP---GIRRwph 218
Cdd:PRK10717 164 TTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTgsalysyyktgelkaEGSSITegiGQGR--- 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488617769 219 eyLPKIYQSDRVDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLST 293
Cdd:PRK10717 241 --ITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELgPGHTIVTILCDSGERYQSK 314
|
|
| cysta_beta |
TIGR01137 |
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ... |
6-292 |
1.25e-88 |
|
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273464 [Multi-domain] Cd Length: 455 Bit Score: 271.67 E-value: 1.25e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 6 QTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAA 85
Cdd:TIGR01137 3 DNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPGDTIIEPTSGNTGIGLALVAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 86 IKGYRMILIMPDNSSAERKAAMTAYGAELI---SVSKDEGMEGARDLAERMQAEGRGKV-LDQFANGDNPEAHYTSTGPE 161
Cdd:TIGR01137 83 IKGYKCIIVLPEKMSSEKVDVLRALGAEIVrtpTAAAFDSPESHIGVAKRLVREIPGAHiLDQYRNPSNPLAHYDTTGPE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 162 IWRQTGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQP-----MEGASIPGIRRWPHE-------YLPKIYQSDR 229
Cdd:TIGR01137 163 ILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPegsilAQPEELNQTGRTPYKvegigydFIPTVLDRKV 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488617769 230 VDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV--ENAVIVAIICDRGDRYLS 292
Cdd:TIGR01137 243 VDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDElqEGQRCVVLLPDSIRNYMT 307
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
8-298 |
1.28e-87 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 264.86 E-value: 1.28e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDT-LIEATSGNTGIALAMAAAI 86
Cdd:PLN02565 9 VTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESvLIEPTSGNTGIGLAFMAAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 87 KGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAEG-RGKVLDQFANGDNPEAHYTSTGPEIWRQ 165
Cdd:PLN02565 89 KGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTpNSYILQQFENPANPKIHYETTGPEIWKG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 166 TGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHE-------YLPKIYQSDRVDRIIDMGQ 238
Cdd:PLN02565 169 TGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKiqgigagFIPGVLDVDLLDEVVQVSS 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488617769 239 TEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENA--VIVAIICDRGDRYLSTGIYDS 298
Cdd:PLN02565 249 DEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAgkLIVVIFPSFGERYLSSVLFES 310
|
|
| PLP_SbnA_fam |
TIGR03945 |
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a ... |
8-297 |
6.47e-85 |
|
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 274872 [Multi-domain] Cd Length: 304 Bit Score: 257.13 E-value: 6.47e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAIK 87
Cdd:TIGR03945 1 ILSLIGNTPLVKLERLFPDAPFRLFAKLEGFNPGGSIKDRPALYILEAAIKRGRITPGTTIIESSSGNLGIALAMICAYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 88 GYRMILIMPDNSSAERKAAMTAYGAELISVS-KDE--GMEGAR-DLAERMQAEGRGKV-LDQFANGDNPEAHYTSTGPEI 162
Cdd:TIGR03945 81 GLRFICVVDPNISPQNLKLLRAYGAEVEKVTePDEtgGYLGTRiARVRELLASIPDAYwPNQYANPDNPRAHYHGTGREI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 163 WRQTgGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGL---------QPMEGASIPGI---RRwpheylPKIYQSDRV 230
Cdd:TIGR03945 161 ARAF-PTLDYLFVGVSTTGTLMGCSRRLRERGPNTKVIAVdavgsvifgGPPGRRHIPGLgasVV------PELLDESLI 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488617769 231 DRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLSTgIYD 297
Cdd:TIGR03945 234 DDVVHVPEYDTVAGCRRLARREGILAGGSSGTVVAAIKRLLPRIpEGSTVVAILPDRGERYLDT-VYN 300
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
15-286 |
5.04e-80 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 242.42 E-value: 5.04e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIhPGDTLIEATSGNTGIALAMAAAIKGYRMILI 94
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL-PKGVIIESTGGNTGIALAAAAARLGLKCTIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 95 MPDNSSAERKAAMTAYGAELISVskDEGMEGARDLAERMQAEGRG-KVLDQFANGDNPEAHYTsTGPEIWRQTGG-TVTH 172
Cdd:cd00640 80 MPEGASPEKVAQMRALGAEVVLV--PGDFDDAIALAKELAEEDPGaYYVNQFDNPANIAGQGT-IGLEILEQLGGqKPDA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 173 FVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPmegasipgirrwpheylpkiyQSDRVDriidmgQTEAEDTMRRLAREE 252
Cdd:cd00640 157 VVVPVGGGGNIAGIARALKELLPNVKVIGVEP---------------------EVVTVS------DEEALEAIRLLAREE 209
|
250 260 270
....*....|....*....|....*....|....*
gi 488617769 253 GIFCGVSSGGSVAGALRISREV-ENAVIVAIICDR 286
Cdd:cd00640 210 GILVEPSSAAALAAALKLAKKLgKGKTVVVILTGG 244
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
8-285 |
5.10e-77 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 236.82 E-value: 5.10e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAElrgQIHPGDTLIEATSGNTGIALAMAAAIK 87
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLK---EGEGGKTVVEASSGNHGRALAAAAARL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 88 GYRMILIMPDNSSAERKAAMTAYGAELISVskDEGMEGARDLAERMQAEGRGKV-LDQFANGDNPEAhYTSTGPEIWRQT 166
Cdd:pfam00291 78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLV--GGDYDEAVAAARELAAEGPGAYyINQYDNPLNIEG-YGTIGLEILEQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 167 GGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIP---------------------GIRRWPHEYLPKIY 225
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALArslaagrpvpvpvadtiadglGVGDEPGALALDLL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488617769 226 QsDRVDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGA-LRISREV-ENAVIVAIICD 285
Cdd:pfam00291 235 D-EYVGEVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALkLALAGELkGGDRVVVVLTG 295
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
12-297 |
6.58e-75 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 233.70 E-value: 6.58e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 12 VGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDT-LIEATSGNTGIALAMAAAIKGYR 90
Cdd:PLN02556 57 IGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTtLIEPTSGNMGISLAFMAAMKGYK 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 91 MILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGA-RDLAERMQAEGRGKVLDQFANGDNPEAHYTSTGPEIWRQTGGT 169
Cdd:PLN02556 137 MILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTvKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPEIWEDTLGQ 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 170 VTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHE-------YLPKIYQSDRVDRIIDMGQTEAE 242
Cdd:PLN02556 217 VDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHitgngvgFKPDILDMDVMEKVLEVSSEDAV 296
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 488617769 243 DTMRRLAREEGIFCGVSSGGSVAGALRISREVEN--AVIVAIICDRGDRYLSTGIYD 297
Cdd:PLN02556 297 NMARELALKEGLMVGISSGANTVAALRLAKMPENkgKLIVTVHPSFGERYLSSVLFQ 353
|
|
| PLN00011 |
PLN00011 |
cysteine synthase |
8-298 |
1.09e-74 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 231.82 E-value: 1.09e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPG-DTLIEATSGNTGIALAMAAAI 86
Cdd:PLN00011 11 VTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEATAGNTGIGLACIGAA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 87 KGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAERMQAEGRGK-VLDQFANGDNPEAHYTSTGPEIWRQ 165
Cdd:PLN00011 91 RGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGyIPQQFENPANPEIHYRTTGPEIWRD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 166 TGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPH-------EYLPKIYQSDRVDRIIDMGQ 238
Cdd:PLN00011 171 SAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHliqgigsGIIPFNLDLTIVDEIIQVTG 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488617769 239 TEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENA--VIVAIICDRGDRYLSTGIYDS 298
Cdd:PLN00011 251 EEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAgkLIVVIFPSGGERYLSTKLFES 312
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
8-298 |
7.93e-71 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 225.04 E-value: 7.93e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDT-LIEATSGNTGIALAMAAAI 86
Cdd:PLN03013 117 VSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSvLVEPTSGNTGIGLAFIAAS 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 87 KGYRMILIMPDNSSAERKAAMTAYGAELISVSKDEGMEGARDLAER-MQAEGRGKVLDQFANGDNPEAHYTSTGPEIWRQ 165
Cdd:PLN03013 197 RGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEiLKNTPDAYMLQQFDNPANPKIHYETTGPEIWDD 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 166 TGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGASIPGIRRWPHE-------YLPKIYQSDRVDRIIDMGQ 238
Cdd:PLN03013 277 TKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKiqgigagFIPKNLDQKIMDEVIAISS 356
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488617769 239 TEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENA-VIVAIICDRGDRYLSTGIYDS 298
Cdd:PLN03013 357 EEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAgKLIAVSLFASGRDIYTPRCSS 417
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
8-298 |
1.11e-42 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 151.68 E-value: 1.11e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPGDTLIEATSGNTGIALAMAAAIK 87
Cdd:PLN02356 47 LIDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVVTEGSAGSTAISLATVAPAY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 88 GYRMILIMPDNSSAERKAAMTAYGAEL--------------ISVSKDEGMEgARDLAE--RMQAEGRGKVL--------- 142
Cdd:PLN02356 127 GCKCHVVIPDDVAIEKSQILEALGATVervrpvsithkdhyVNIARRRALE-ANELASkrRKGSETDGIHLektngcise 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 143 ------------------DQFANGDNPEAHYTSTGPEIWRQTGGTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQP 204
Cdd:PLN02356 206 eekenslfsssctggffaDQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 205 -------------------MEGASIP----------GIRRWPHEYLpkIYQSDRVDRIIDMgqtEAEDTMRRLAREEGIF 255
Cdd:PLN02356 286 pgsglfnkvtrgvmytreeAEGRRLKnpfdtitegiGINRLTQNFL--MAKLDGAFRGTDK---EAVEMSRYLLKNDGLF 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 488617769 256 CGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLSTgIYDS 298
Cdd:PLN02356 361 VGSSSAMNCVGAVRVAQSLgPGHTIVTILCDSGMRHLSK-FHDP 403
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
13-284 |
3.04e-24 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 99.98 E-value: 3.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRLQRMA-GNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQihpgDTLIEATSGNTGIALAMAAAIKGYRM 91
Cdd:cd01563 21 GNTPLVRAPRLGeRLGGKNLYVKDEGLNPTGSFKDRGMTVAVSKAKELGV----KAVACASTGNTSASLAAYAARAGIKC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 92 ILIMPDNSSAERKAAMTAYGAELISVskdegmEGARDLAERMQAEGRGKVLDQFANGDNPEAH--YTSTGPEIWRQTGGT 169
Cdd:cd01563 97 VVFLPAGKALGKLAQALAYGATVLAV------EGNFDDALRLVRELAEENWIYLSNSLNPYRLegQKTIAFEIAEQLGWE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 170 V-THFVSSMGTTGTIMGTSRYLKEQ------NPEVQIVGLQPmEGAS---------------------------IPGIRR 215
Cdd:cd01563 171 VpDYVVVPVGNGGNITAIWKGFKELkelgliDRLPRMVGVQA-EGAApivrafkegkddiepvenpetiatairIGNPAS 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488617769 216 WPhEYLPKIYQSDrvDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREV---ENAVIVAIIC 284
Cdd:cd01563 250 GP-KALRAVRESG--GTAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEGiidKGERVVVVLT 318
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
12-283 |
4.94e-23 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 97.58 E-value: 4.94e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 12 VGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIhpgdTLIEATSGNTGIALAMAAAIKGYRM 91
Cdd:COG0498 64 EGGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAK----TIVCASSGNGSAALAAYAARAGIEV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 92 ILIMP-DNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAERmqaEGRGkvldqFANGDNP---EAhYTSTGPEIWRQ 165
Cdd:COG0498 140 FVFVPeGKVSPGQLAQMLTYGAHVIAVdgNFDDAQRLVKELAAD---EGLY-----AVNSINParlEG-QKTYAFEIAEQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 166 TGGTVTHFVSSMGTTGTI--------MGTSRYLKEQNPevQIVGLQPmEGASiPGIRRWphEYLPKIYQSDRVDRI---I 234
Cdd:COG0498 211 LGRVPDWVVVPTGNGGNIlagykafkELKELGLIDRLP--RLIAVQA-TGCN-PILTAF--ETGRDEYEPERPETIapsM 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488617769 235 DMGQ---------------------TEAE--DTMRRLAREEGIFCGVSSGGSVAGALRISREVE---NAVIVAII 283
Cdd:COG0498 285 DIGNpsngeralfalresggtavavSDEEilEAIRLLARREGIFVEPATAVAVAGLRKLREEGEidpDEPVVVLS 359
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
6-284 |
1.32e-22 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 95.49 E-value: 1.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 6 QTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITR--AELRGQihpgdTLIEATSGNTGIALAMA 83
Cdd:COG1171 16 ARIAGVVRRTPLLRSPTLSERLGAEVYLKLENLQPTGSFKLRGAYNALASlsEEERAR-----GVVAASAGNHAQGVAYA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 84 AAIKGYRMILIMPDNSSAERKAAMTAYGAELISVskDEGMEGARDLAERMQAEgRGKVLDQ-FangDNPE--AHYTSTGP 160
Cdd:COG1171 91 ARLLGIPATIVMPETAPAVKVAATRAYGAEVVLH--GDTYDDAEAAAAELAEE-EGATFVHpF---DDPDviAGQGTIAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 161 EIWRQTGGtVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQP------------------------MEGASIPGIRRW 216
Cdd:COG1171 165 EILEQLPD-LDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPegaaamyrslaagepvtlpgvdtiADGLAVGRPGEL 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488617769 217 PHEYLpkiyqSDRVDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENAVIVAIIC 284
Cdd:COG1171 244 TFEIL-----RDLVDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKERLKGKRVVVVLS 306
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
5-284 |
1.42e-21 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 92.16 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMI---TRAELRGQIhpgdtlIEATSGNTGIALA 81
Cdd:cd01562 8 AARIKPVVRRTPLLTSPTLSELLGAEVYLKCENLQKTGSFKIRGAYNKLlslSEEERAKGV------VAASAGNHAQGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 82 MAAAIKGYRMILIMPDNSSAERKAAMTAYGAELISVskDEGMEGARDLAERMQAEGRGKVLDQFangDNPE--AHYTSTG 159
Cdd:cd01562 82 YAAKLLGIPATIVMPETAPAAKVDATRAYGAEVVLY--GEDFDEAEAKARELAEEEGLTFIHPF---DDPDviAGQGTIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 160 PEIWRQTGGTVTHFVS-SMGttGTIMGTSRYLKEQNPEVQIVGLQPmEGA-----SIPGIRRWPHEYLPKI--------- 224
Cdd:cd01562 157 LEILEQVPDLDAVFVPvGGG--GLIAGIATAVKALSPNTKVIGVEP-EGApamaqSLAAGKPVTLPEVDTIadglavkrp 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488617769 225 ------YQSDRVDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENAVIVAIIC 284
Cdd:cd01562 234 geltfeIIRKLVDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKLDLKGKKVVVVLS 299
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
5-286 |
1.55e-19 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 86.67 E-value: 1.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITR--AELRGQihpgdTLIEATSGNTGIALAM 82
Cdd:PRK06815 11 HQRLRPQVRVTPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLRLlnEAQRQQ-----GVITASSGNHGQGVAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 83 AAAIKGYRMILIMPDNSSAERKAAMTAYGAELISVSKDegMEGArDLAERMQAEGRGKVLDQFANGDNPEAHYTSTGPEI 162
Cdd:PRK06815 86 AAKLAGIPVTVYAPEQASAIKLDAIRALGAEVRLYGGD--ALNA-ELAARRAAEQQGKVYISPYNDPQVIAGQGTIGMEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 163 WRQTGGTVTHFVsSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEGA----SIPGIRRWPHEYLPKIyqSD---------- 228
Cdd:PRK06815 163 VEQQPDLDAVFV-AVGGGGLISGIATYLKTLSPKTEIIGCWPANSPslytSLEAGEIVEVAEQPTL--SDgtaggvepga 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488617769 229 --------RVDRIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENAVIVAIICDR 286
Cdd:PRK06815 240 itfplcqqLIDQKVLVSEEEIKEAMRLIAETDRWLIEGAAGVALAAALKLAPRYQGKKVAVVLCGK 305
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
11-269 |
6.14e-15 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 73.96 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 11 CVGNTPLVRLQRMAGN-TSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQihpgDTLIEATSGNTGIALAMAAAIKGY 89
Cdd:TIGR00260 19 GEGVTPLFRAPALAANvGIKNLYVKELGHNPTLSFKDRGMAVALTKALELGN----DTVLCASTGNTGAAAAAYAGKAGL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 90 RMILIMPDNSSAERKAAMT-AYGAELISVSK--DEGMEGARDLAERMQAEGRGKVLDQFAngdNPEAHYTsTGPEIWRQT 166
Cdd:TIGR00260 95 KVVVLYPAGKISLGKLAQAlGYNAEVVAIDGnfDDAQRLVKQLFEDKPALGLNSANSIPY---RLEGQKT-YAFEAVEQL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 167 GGTV-THFVSSMGTTGTIMGTSRYLKEQNpEVQIVGLQPM-----EGASiPGIRRW-------PHEYLPKIYQS------ 227
Cdd:TIGR00260 171 GWEApDKVVVPVPNSGNFGAIWKGFKEKK-MLGLDSLPVKrgiqaEGAA-DIVRAFleggqwePIETPETLSTAmdignp 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 488617769 228 ---DRVDRIIDMGQTEAED--------TMRRLAREEGIFCGVSSGGSVAGALR 269
Cdd:TIGR00260 249 anwPRALEAFRRSNGYAEDlsdeeileAIKLLAREEGYFVEPHSAVAVAALLK 301
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
13-133 |
2.25e-13 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 69.35 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRLQRMAGN-TSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQihpgDTLIEATSGNTGIALAMAAAIKGYRM 91
Cdd:PRK06381 14 GGTPLLRARKLEEElGLRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY----SGITVGTCGNYGASIAYFARLYGLKA 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 488617769 92 ILIMPDNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAERM 133
Cdd:PRK06381 90 VIFIPRSYSNSRVKEMEKYGAEIIYVdgKYEEAVERSRKFAKEN 133
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
15-204 |
3.30e-11 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 63.66 E-value: 3.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPA---LSMITRAEL-RGqihpgdtLIEATSGNTGIALAMAAAIKGYR 90
Cdd:PRK12483 38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIRGAynkMARLPAEQLaRG-------VITASAGNHAQGVALAAARLGVK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 91 MILIMPDNSSAERKAAMTAYGAELisVSKDEGMEGARDLAERMQAEGRGKVLDQFangDNPE--AHYTSTGPEIWRQTGG 168
Cdd:PRK12483 111 AVIVMPRTTPQLKVDGVRAHGGEV--VLHGESFPDALAHALKLAEEEGLTFVPPF---DDPDviAGQGTVAMEILRQHPG 185
|
170 180 190
....*....|....*....|....*....|....*.
gi 488617769 169 TVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQP 204
Cdd:PRK12483 186 PLDAIFVPVGGGGLIAGIAAYVKYVRPEIKVIGVEP 221
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
5-207 |
6.07e-11 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 62.10 E-value: 6.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVR---LQRMAGNTsntLLLKLEGNNPAGSVKDRPALSmiTRAELRGQIHPGDTLIEATSGNTGIALA 81
Cdd:PRK06608 14 HNRIKQYLHLTPIVHsesLNEMLGHE---IFFKVESLQKTGAFKVRGVLN--HLLELKEQGKLPDKIVAYSTGNHGQAVA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 82 MAAAIKGYRMILIMPDNSSAERKAAMTAYGAELI-SVSKDEGMEGARdlaermQAEGRGKVLDQFANGDNPEAHYTSTGP 160
Cdd:PRK06608 89 YASKLFGIKTRIYLPLNTSKVKQQAALYYGGEVIlTNTRQEAEEKAK------EDEEQGFYYIHPSDSDSTIAGAGTLCY 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 488617769 161 EIWRQTGGTVTHFVSSMGTTGTIMGTsrYLKEQ--NPEVQIVGLQPMEG 207
Cdd:PRK06608 163 EALQQLGFSPDAIFASCGGGGLISGT--YLAKEliSPTSLLIGSEPLNA 209
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
13-280 |
5.03e-10 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 59.83 E-value: 5.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRlQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRaelrGQIHPGDTLIEATSGNTGIALAMAAAIKGYRMI 92
Cdd:PRK05638 65 GGTPLIR-ARISEKLGENVYIKDETRNPTGSFRDRLATVAVSY----GLPYAANGFIVASDGNAAASVAAYSARAGKEAF 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 93 LIMPDNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAermqaegRGKVLDQFANGDN---PEAHYTsTGPEIWRQTG 167
Cdd:PRK05638 140 VVVPRKVDKGKLIQMIAFGAKIIRYgeSVDEAIEYAEELA-------RLNGLYNVTPEYNiigLEGQKT-IAFELWEEIN 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 168 GTvtHFVSSMGTTGTIM----GTSRYLK----EQNPE---VQIVGLQPMeGASIPGIRRWPHE------YLPKIYQSDRV 230
Cdd:PRK05638 212 PT--HVIVPTGSGSYLYsiykGFKELLEigviEEIPKliaVQTERCNPI-ASEILGNKTKCNEtkalglYVKNPVMKEYV 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488617769 231 DRIID-MGQT------EAEDTMRRLAREEGIFCGVSSGGSVAGALRISRE-----VENAVIV 280
Cdd:PRK05638 289 SEAIKeSGGTavvvneEEIMAGEKLLAKEGIFAELSSAVVMPALLKLGEEgyiekGDKVVLV 350
|
|
| PRK06110 |
PRK06110 |
threonine dehydratase; |
33-139 |
5.94e-10 |
|
threonine dehydratase;
Pssm-ID: 235699 Cd Length: 322 Bit Score: 59.24 E-value: 5.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 33 LKLEGNNPAGSVKDRPALSMITRAELRGQIHPGdtLIEATSGNTGIALAMAAAIKGYRMILIMPDNSSAERKAAMTAYGA 112
Cdd:PRK06110 40 VKHENHTPTGAFKVRGGLVYFDRLARRGPRVRG--VISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGA 117
|
90 100
....*....|....*....|....*..
gi 488617769 113 ELISVSKDegMEGARDLAERMqAEGRG 139
Cdd:PRK06110 118 ELIEHGED--FQAAREEAARL-AAERG 141
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
31-204 |
1.06e-09 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 59.16 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 31 LLLKLEGNNPAGSVKDRPALSMITRAElRGQIHPGdtLIEATSGNTGIALAMAAAIKGYRMILIMPDNSSAERKAAMTAY 110
Cdd:PLN02550 126 VLLKREDLQPVFSFKLRGAYNMMAKLP-KEQLDKG--VICSSAGNHAQGVALSAQRLGCDAVIAMPVTTPEIKWQSVERL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 111 GAELISV--SKDEGMEGARdlaERMQAEGRgKVLDQFangDNPE--AHYTSTGPEIWRQTGGTVTHFVSSMGTTGTIMGT 186
Cdd:PLN02550 203 GATVVLVgdSYDEAQAYAK---QRALEEGR-TFIPPF---DHPDviAGQGTVGMEIVRQHQGPLHAIFVPVGGGGLIAGI 275
|
170
....*....|....*...
gi 488617769 187 SRYLKEQNPEVQIVGLQP 204
Cdd:PLN02550 276 AAYVKRVRPEVKIIGVEP 293
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
13-273 |
5.04e-09 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 56.55 E-value: 5.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRLQRMAGNTS-NTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHpgdtLIEATSGNTGIALAMAAAIKGYRM 91
Cdd:PRK08197 78 GMTPLLPLPRLGKALGiGRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKH----LAMPTNGNAGAAWAAYAARAGIRA 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 92 ILIMPDNSSAERKAAMTAYGAELISVskdegmEGARDLAERMQAEGRGKV--LDqfangdnpeahyTST----------- 158
Cdd:PRK08197 154 TIFMPADAPEITRLECALAGAELYLV------DGLISDAGKIVAEAVAEYgwFD------------VSTlkepyriegkk 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 159 --GPEIWRQTGGTVTH--FVSSMGTTGTI--------MGTSRYLKEQNPE---VQIVGLQPMEGASIPGIRR---WPHEY 220
Cdd:PRK08197 216 tmGLELAEQLGWRLPDviLYPTGGGVGLIgiwkafdeLEALGWIGGKRPRlvaVQAEGCAPIVKAWEEGKEEsefWEDAH 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488617769 221 -------LPK----------IYQSDRVDRIIDMGQTEAEdtMRRLAREEGIF-CgvSSGGSVAGALRISRE 273
Cdd:PRK08197 296 tvafgirVPKalgdflvldaVRETGGCAIAVSDDAILAA--QRELAREEGLFaC--PEGAATFAAARQLRE 362
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
13-128 |
1.56e-08 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 55.13 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 13 GNTPLVRlqrmagntSNTLLLKLEGNNPAGSVKDRPALSMITR-AELR-GQIHpgdtliEATSGNTGIALAMAAAIKGYR 90
Cdd:PRK06450 57 GRTPLIK--------KGNIWFKLDFLNPTGSYKDRGSVTLISYlAEKGiKQIS------EDSSGNAGASIAAYGAAAGIE 122
|
90 100 110
....*....|....*....|....*....|....*...
gi 488617769 91 MILIMPDNSSAERKAAMTAYGAELISVskdegmEGARD 128
Cdd:PRK06450 123 VKIFVPETASGGKLKQIESYGAEVVRV------RGSRE 154
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
15-203 |
3.30e-08 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 53.97 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPA---LSMITRAELRGQIhpgdtlIEATSGNTGIALAMAAAIKGYRM 91
Cdd:PRK08638 28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAfnkLSSLTDAEKRKGV------VACSAGNHAQGVALSCALLGIDG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 92 ILIMPDNSSAERKAAMTAYGAELISVSK--DEGMEGARDLAERmqaEGRgKVLDQFangDNPE--AHYTSTGPEIWRQTg 167
Cdd:PRK08638 102 KVVMPKGAPKSKVAATCGYGAEVVLHGDnfNDTIAKVEEIVEE---EGR-TFIPPY---DDPKviAGQGTIGLEILEDL- 173
|
170 180 190
....*....|....*....|....*....|....*.
gi 488617769 168 GTVTHFVSSMGTTGTIMGTSRYLKEQNPEVQIVGLQ 203
Cdd:PRK08638 174 WDVDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQ 209
|
|
| PLN02569 |
PLN02569 |
threonine synthase |
10-120 |
2.29e-07 |
|
threonine synthase
Pssm-ID: 178182 [Multi-domain] Cd Length: 484 Bit Score: 51.74 E-value: 2.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 10 DCV----GNTPLVRLQRMAGNTS--NTLLLKLEGNNPAGSVKDR---PALSMITRaeLRGQIHPGDTLIEATSGNTGIAL 80
Cdd:PLN02569 125 DIVslfeGNSNLFWAERLGKEFLgmNDLWVKHCGISHTGSFKDLgmtVLVSQVNR--LRKMAKPVVGVGCASTGDTSAAL 202
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488617769 81 AMAAAIKGYRMILIMPDNS-SAERKAAMTAYGAELISVSKD 120
Cdd:PLN02569 203 SAYCAAAGIPSIVFLPADKiSIAQLVQPIANGALVLSIDTD 243
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
5-132 |
2.66e-07 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 51.11 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVRLqRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELrgqihPGDTLIEATSGNTGIALAMAA 84
Cdd:PRK08246 14 AQRIAPHIRRTPVLEA-DGAGFGPAPVWLKLEHLQHTGSFKARGAFNRLLAAPV-----PAAGVVAASGGNAGLAVAYAA 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488617769 85 AIKGYRMILIMPDNSSAERKAAMTAYGAELISVSKD--EGMEGARDLAER 132
Cdd:PRK08246 88 AALGVPATVFVPETAPPAKVARLRALGAEVVVVGAEyaDALEAAQAFAAE 137
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
15-279 |
3.12e-07 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 51.17 E-value: 3.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLQRMAgntsntLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHPgdtLIEATSGNTGIALAMAAAIKGYRMILI 94
Cdd:PRK08813 40 TPLHYAERFG------VWLKLENLQRTGSYKVRGALNALLAGLERGDERP---VICASAGNHAQGVAWSAYRLGVQAITV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 95 MPDNSSAERKAAMTAYGAELIS--VSKDEGMEGARDLAERMQAegrgKVLDQFangDNPE--AHYTSTGPEIWRQTGGTV 170
Cdd:PRK08813 111 MPHGAPQTKIAGVAHWGATVRQhgNSYDEAYAFARELADQNGY----RFLSAF---DDPDviAGQGTVGIELAAHAPDVV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 171 thfVSSMGTTGTIMGTSRYLKEQNpeVQIVGLQpMEG---------------ASIP----GIRRWPHEYLPKIYQSDRVD 231
Cdd:PRK08813 184 ---IVPIGGGGLASGVALALKSQG--VRVVGAQ-VEGvdsmarairgdlreiAPVAtladGVKVKIPGFLTRRLCSSLLD 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 488617769 232 RIIDMGQTEAEDTMRRLAREEGIFCGVSSGGSVAGALRISREVENAVI 279
Cdd:PRK08813 258 DVVIVREAELRETLVRLALEEHVIAEGAGALALAAGRRVSGKRKCAVV 305
|
|
| PRK08206 |
PRK08206 |
diaminopropionate ammonia-lyase; Provisional |
67-115 |
2.26e-06 |
|
diaminopropionate ammonia-lyase; Provisional
Pssm-ID: 236186 Cd Length: 399 Bit Score: 48.34 E-value: 2.26e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 488617769 67 TLIEATSGNTGIALAMAAAIKGYRMILIMPDNSSAERKAAMTAYGAELI 115
Cdd:PRK08206 118 TFATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECI 166
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
15-120 |
2.38e-06 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 48.28 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLqrmagntSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQihpgDTLIEATSGNTGIALAMAAAIKGYRMILI 94
Cdd:PRK08329 65 TPTVKR-------SIKVYFKLDYLQPTGSFKDRGTYVTVAKLKEEGI----NEVVIDSSGNAALSLALYSLSEGIKVHVF 133
|
90 100
....*....|....*....|....*.
gi 488617769 95 MPDNSSAERKAAMTAYGAELISVSKD 120
Cdd:PRK08329 134 VSYNASKEKISLLSRLGAELHFVEGD 159
|
|
| PRK07048 |
PRK07048 |
threo-3-hydroxy-L-aspartate ammonia-lyase; |
6-207 |
2.94e-06 |
|
threo-3-hydroxy-L-aspartate ammonia-lyase;
Pssm-ID: 235918 [Multi-domain] Cd Length: 321 Bit Score: 48.09 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 6 QTIADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDR---PALSMITRAELRGQIhpgdtlIEATSGNTGIALAM 82
Cdd:PRK07048 16 ARLAGVAHRTPVLTSRTADARTGAQVFFKCENFQRMGAFKFRgayNALSQFSPEQRRAGV------VTFSSGNHAQAIAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 83 AAAIKGYRMILIMPDNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAERmqaegRGKVLdqFANGDNPE--AHYTST 158
Cdd:PRK07048 90 SARLLGIPATIVMPQDAPAAKVAATRGYGGEVVTYdrYTEDREEIGRRLAEE-----RGLTL--IPPYDHPHviAGQGTA 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 488617769 159 GPEIWRQTGGTVTHFVsSMGTTGTIMGTSRYLKEQNPEVQIVGLQPMEG 207
Cdd:PRK07048 163 AKELFEEVGPLDALFV-CLGGGGLLSGCALAARALSPGCKVYGVEPEAG 210
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
15-204 |
6.15e-06 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 47.44 E-value: 6.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 15 TPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMI---TRAEL-RGqihpgdtLIEATSGNTGIALAMAAAIKGYR 90
Cdd:PRK09224 21 TPLEKAPKLSARLGNQVLLKREDLQPVFSFKLRGAYNKMaqlTEEQLaRG-------VITASAGNHAQGVALSAARLGIK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 91 MILIMPDNSSAERKAAMTAYGAE--LISVSKDEGMEGARDLAERmqaEGRGKVldqfANGDNPE--AHYTSTGPEIWRQT 166
Cdd:PRK09224 94 AVIVMPVTTPDIKVDAVRAFGGEvvLHGDSFDEAYAHAIELAEE---EGLTFI----HPFDDPDviAGQGTIAMEILQQH 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 488617769 167 GGTVTH-FVSsMGTTGTIMGTSRYLKEQNPEVQIVGLQP 204
Cdd:PRK09224 167 PHPLDAvFVP-VGGGGLIAGVAAYIKQLRPEIKVIGVEP 204
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
8-131 |
9.06e-06 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 46.50 E-value: 9.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 8 IADCVGNTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPA----LSMITRAELRGqihpgdtLIEATSGNTGIALAMA 83
Cdd:PRK07476 13 IAGRVRRTPLVASASLSARAGVPVWLKLETLQPTGSFKLRGAtnalLSLSAQERARG-------VVTASTGNHGRALAYA 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 488617769 84 AAIKGYRMILIMPDNSSAERKAAMTAYGAELISV--SKDEGMEGARDLAE 131
Cdd:PRK07476 86 ARALGIRATICMSRLVPANKVDAIRALGAEVRIVgrSQDDAQAEVERLVR 135
|
|
| PLN02970 |
PLN02970 |
serine racemase |
5-209 |
2.00e-03 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 39.28 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 5 YQTIADCVGNTPLVR---LQRMAGNTsntLLLKLEGNNPAGSVKDRPA----LSMITRAELRGqihpgdtLIEATSGNTG 77
Cdd:PLN02970 18 RKRIAPFIHRTPVLTsssLDALAGRS---LFFKCECFQKGGAFKFRGAcnaiFSLSDDQAEKG-------VVTHSSGNHA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 78 IALAMAAAIKGYRMILIMPDNSSAERKAAMTAYGAELISVskDEGMEGARDLAERMQAEgRGKVLdqfangdnpeAHYTS 157
Cdd:PLN02970 88 AALALAAKLRGIPAYIVVPKNAPACKVDAVIRYGGIITWC--EPTVESREAVAARVQQE-TGAVL----------IHPYN 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488617769 158 TGPEIWRQtgGTVT-HFVSSM----------GTTGTIMGTSRYLKEQNPEVQIVGLQPmEGAS 209
Cdd:PLN02970 155 DGRVISGQ--GTIAlEFLEQVpeldviivpiSGGGLISGIALAAKAIKPSIKIIAAEP-KGAD 214
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
14-132 |
2.49e-03 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 38.82 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 14 NTPLVRLQRMAGNTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQ---IHpgdtLIEATSGNTGIALAMAAAIKGYR 90
Cdd:cd06448 1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRGIGHLCQKSAKQGLnecVH----VVCSSGGNAGLAAAYAARKLGVP 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 488617769 91 MILIMPDNSSAERKAAMTAYGAELI---SVSKDEGMEGARDLAER 132
Cdd:cd06448 77 CTIVVPESTKPRVVEKLRDEGATVVvhgKVWWEADNYLREELAEN 121
|
|
| Trp-synth_B |
cd06446 |
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ... |
176-293 |
4.62e-03 |
|
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Pssm-ID: 107207 Cd Length: 365 Bit Score: 38.29 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488617769 176 SMGTTGTIMGTSRYLKeQNPEVQIVglqpmEGASIPGIRRWP-----HEYLpkiYQSDRVDrIIDMGQTEAEDTMRRLAR 250
Cdd:cd06446 251 FGGTAGVLHGLKMYTL-QDEDGQIV-----PPHSISAGLDYPgvgpeHAYL---KDSGRVE-YVAVTDEEALEAFKLLAR 320
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 488617769 251 EEGIFCGVSSGGSVAGALRISREV-ENAVIVAIICDRGDRYLST 293
Cdd:cd06446 321 TEGIIPALESSHAIAYAIKLAKKLgKEKVIVVNLSGRGDKDLQT 364
|
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