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Conserved domains on  [gi|488618150|ref|WP_002554999|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Pseudomonas]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-100 3.70e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 92.65  E-value: 3.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   3 IDLDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFF 82
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLA-------------EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 488618150  83 RRNEEVIQAFVQALVEEL 100
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-100 3.70e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 92.65  E-value: 3.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   3 IDLDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFF 82
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLA-------------EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 488618150  83 RRNEEVIQAFVQALVEEL 100
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-92 2.05e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 69.80  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   5 LDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFR- 83
Cdd:NF033788   1 LAELFKALADPTRLRILELLA-------------EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRl 67


                 ....*....
gi 488618150  84 RNEEVIQAF 92
Cdd:NF033788  68 ADEHVAELL 76
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-94 1.73e-15

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 65.13  E-value: 1.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150  10 KALAHPVRREILTWLKDPRASfpaqqysiehgvcAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRN---- 85
Cdd:NF033789   3 KALSDPTRREILELLKEGDMT-------------AGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNttvf 69


                 ....*....
gi 488618150  86 EEVIQAFVQ 94
Cdd:NF033789  70 EEVLGWLLD 78
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-98 2.14e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.01  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   9 IKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRNE-E 87
Cdd:cd00090    1 LKALSDPTRLRILRLLL-------------EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaE 67

                         90
                 ....*....|.
gi 488618150  88 VIQAFVQALVE 98
Cdd:cd00090   68 RLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
39-97 2.50e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 59.53  E-value: 2.50e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 488618150    39 EHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRNEEVIQAFVQALV 97
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-78 3.26e-13

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.09  E-value: 3.26e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488618150    6 DDIIKALAHPVRREILTWLKDPRasfpaqqysiehGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQ 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-100 3.70e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 92.65  E-value: 3.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   3 IDLDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFF 82
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLA-------------EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 488618150  83 RRNEEVIQAFVQALVEEL 100
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-92 2.05e-17

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 69.80  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   5 LDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFR- 83
Cdd:NF033788   1 LAELFKALADPTRLRILELLA-------------EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRl 67


                 ....*....
gi 488618150  84 RNEEVIQAF 92
Cdd:NF033788  68 ADEHVAELL 76
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-94 1.73e-15

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 65.13  E-value: 1.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150  10 KALAHPVRREILTWLKDPRASfpaqqysiehgvcAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRN---- 85
Cdd:NF033789   3 KALSDPTRREILELLKEGDMT-------------AGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNttvf 69


                 ....*....
gi 488618150  86 EEVIQAFVQ 94
Cdd:NF033789  70 EEVLGWLLD 78
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-98 2.14e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 65.01  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   9 IKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRNE-E 87
Cdd:cd00090    1 LKALSDPTRLRILRLLL-------------EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaE 67

                         90
                 ....*....|.
gi 488618150  88 VIQAFVQALVE 98
Cdd:cd00090   68 RLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
39-97 2.50e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 59.53  E-value: 2.50e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 488618150    39 EHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQWHFFRRNEEVIQAFVQALV 97
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-78 3.26e-13

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 59.09  E-value: 3.26e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488618150    6 DDIIKALAHPVRREILTWLKDPRasfpaqqysiehGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVGQ 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
4-77 1.23e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 58.89  E-value: 1.23e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488618150   4 DLDDIIKALAHPVRREILTWLKDPRASfpaqqysiehgvcAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVG 77
Cdd:COG1777    6 DLDRLLDALGNPTRRRILALLSEEPAY-------------VSELARELGVSRQAVYKHLRKLEEAGLVESYREG 66
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
2-76 4.09e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 57.28  E-value: 4.09e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488618150   2 PIDLDDIIKALAHPVRREILTWLKdprasfpaqqysiEHGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKV 76
Cdd:COG4189    6 DEESLEVLKALASETRLRILRLLA-------------EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-77 3.06e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 45.64  E-value: 3.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488618150   8 IIKALAHPVRREILT-WLKDPRASFpaqqysiehgvcaGQIDQRAGLSQSTVSAHLATLQRAGLISSKKVG 77
Cdd:COG3398   90 ILAYLRRETPRRILLyLLENPGATN-------------KELAEELGISRSTVSWHLKRLEEDGLVERERDG 147
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-71 7.20e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 39.73  E-value: 7.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488618150   14 HPVRREILTWL-KDPRasfpaqqysiehgvCAGQIDQRAGLSQSTVSAHLATLQRAGLI 71
Cdd:pfam01022   1 DPTRLKILKLLaEGEL--------------CVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
1-104 6.40e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.48  E-value: 6.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150   1 MPIDLDDIIKALAHPVRREILTWLKD-PrasfpaqqysiehGVCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKV-GQ 78
Cdd:COG3398    7 LGYRRITRKNVLDNDTRRRIYEYIREnP-------------GIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDgGR 73

                         90       100
                 ....*....|....*....|....*.
gi 488618150  79 WHFFrRNEEVIQAFVQALVEELNNPT 104
Cdd:COG3398   74 TRYF-PNSGTYSEEEKKILAYLRRET 98
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
11-100 5.00e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 34.51  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488618150  11 ALAHPVRREILTWLKdprasfpaqqysiEHG-VCAGQIDQRAGLSQSTVSAHLATLQRAGLISSKKV------------- 76
Cdd:COG2345    9 ALADPTRRRILELLK-------------RAGpVTAAELAEALGLTPNAVRRHLDALEEEGLVERETErrgrgrpaklyrl 75

                         90       100
                 ....*....|....*....|....*..
gi 488618150  77 ---GQWHFFRRNEEVIQAFVQALVEEL 100
Cdd:COG2345   76 teaGRARFPRAYDDLAVALLDALRELL 102
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 39-85 5.47e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 32.96  E-value: 5.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488618150  39 EHGvcaGQIDQRA-----GLSQSTVSAHLATLQRAGLISSKKVGqwhffRRN 85
Cdd:COG2512   26 ENG---GRMTQSEivketGWSKSKVSRLLSRLEERGLIEKERVG-----REN 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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