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Conserved domains on  [gi|488810364|ref|WP_002722770|]
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Lrp/AsnC family transcriptional regulator [Cereibacter sphaeroides]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 3.97e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 113.72  E-value: 3.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364   1 MLDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLdktDPRAF 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488810364  81 DEFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITDIEALM 138
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 3.97e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 113.72  E-value: 3.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364   1 MLDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLdktDPRAF 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488810364  81 DEFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITDIEALM 138
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 2-111 1.53e-17

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 72.93  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364     2 LDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLDktDPRAFD 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE--NPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 488810364    82 EFLAAARTVPEVIGIETFLGRVDVRLNVIA 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-133 2.36e-12

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 60.93  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364   2 LDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLDKTDPRAFD 81
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488810364  82 EFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITD 133
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVND 143
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 1.55e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 50.51  E-value: 1.55e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 488810364    4 DTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVI 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-48 1.80e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488810364   1 MLDDTDRRLLRhLLAEPALGTAELAARAGLTTATCWRRLERLTERGVI 48
Cdd:cd00090    4 LSDPTRLRILR-LLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 3.97e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 113.72  E-value: 3.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364   1 MLDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLdktDPRAF 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488810364  81 DEFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITDIEALM 138
Cdd:COG1522   79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSF 136
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 2-111 1.53e-17

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 72.93  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364     2 LDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLDktDPRAFD 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLE--NPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 488810364    82 EFLAAARTVPEVIGIETFLGRVDVRLNVIA 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-133 2.36e-12

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 60.93  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488810364   2 LDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEVEVSLRFTLDKTDPRAFD 81
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488810364  82 EFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITD 133
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVND 143
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 1.55e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 50.51  E-value: 1.55e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 488810364    4 DTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVI 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-135 4.12e-09

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 50.22  E-value: 4.12e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488810364   74 KTDPR-AFDEFLAAARTVPEVIGIETFLGRVDVRLNVIARDMKHYQELYRSRILSLPHITDIE 135
Cdd:pfam01037   4 KLEPGhALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTE 66
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
3-42 1.01e-08

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 48.13  E-value: 1.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 488810364    3 DDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERL 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 2-64 6.84e-07

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 46.24  E-value: 6.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488810364   2 LDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQAVIDWRRLGYEV 64
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDV 69
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-53 2.36e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.52  E-value: 2.36e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488810364   1 MLDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGARQA 53
Cdd:COG2345   10 LADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETE 62
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
1-51 5.76e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.94  E-value: 5.76e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488810364   1 MLDDTDRRLLRHLLAEPALGTAELAARAGLTTATCWRRLERLTERGVIGAR 51
Cdd:COG3398   94 LRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE 144
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-48 1.80e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488810364   1 MLDDTDRRLLRhLLAEPALGTAELAARAGLTTATCWRRLERLTERGVI 48
Cdd:cd00090    4 LSDPTRLRILR-LLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV 50
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
2-56 7.67e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 34.55  E-value: 7.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488810364   2 LDDTDRRLLRHLLAEPA-LGTAELAARAGLTTATCWRRLERLTERGVIGARQAVID 56
Cdd:COG3355   25 LSETDAEVYLILLENGEpLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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