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Conserved domains on  [gi|488865219|ref|WP_002777458|]
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cation:proton antiporter [Campylobacter coli]

Protein Classification

cation:proton antiporter( domain architecture ID 10008671)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to K(+) efflux antiporters that are involved in K(+) homeostasis and osmotic adjustment

CATH:  1.20.1530.20
Gene Ontology:  GO:0006812|GO:0015078|GO:0015297|GO:0016020|GO:1902600
PubMed:  9537504|12027219|16734752|12502567|17218973
TCDB:  2.A.37

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-498 1.54e-94

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 298.81  E-value: 1.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   4 FLEIFLItAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIY--HLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQ 81
Cdd:COG4651    7 ITTIALI-LGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTpgLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  82 EVFLNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLL 161
Cdd:COG4651   86 IALPGALLQIALTTLLGFGIAL-LLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLML 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 162 LLVDIFSSNNQNIGQLLLTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:COG4651  165 VLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 242 AFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFgIVCGFLFLYTK--KR 319
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKP-LIAFLIVLALGypLR 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 320 VALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVEDMTLNTNVVQQS--THS 397
Cdd:COG4651  324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDrpEES 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 398 TLKNHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITNEAK 477
Cdd:COG4651  404 DLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAA 483

                        490       500
                 ....*....|....*....|.
gi 488865219 478 LEMICQVLASYPKPIDTIIHV 498
Cdd:COG4651  484 ALLLIAAARRALPLLIIIARA 504
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-498 1.54e-94

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 298.81  E-value: 1.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   4 FLEIFLItAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIY--HLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQ 81
Cdd:COG4651    7 ITTIALI-LGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTpgLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  82 EVFLNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLL 161
Cdd:COG4651   86 IALPGALLQIALTTLLGFGIAL-LLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLML 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 162 LLVDIFSSNNQNIGQLLLTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:COG4651  165 VLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 242 AFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFgIVCGFLFLYTK--KR 319
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKP-LIAFLIVLALGypLR 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 320 VALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVEDMTLNTNVVQQS--THS 397
Cdd:COG4651  324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDrpEES 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 398 TLKNHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITNEAK 477
Cdd:COG4651  404 DLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAA 483

                        490       500
                 ....*....|....*....|.
gi 488865219 478 LEMICQVLASYPKPIDTIIHV 498
Cdd:COG4651  484 ALLLIAAARRALPLLIIIARA 504
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 7-489 2.59e-76

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 252.61  E-value: 2.59e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   7 IFLITAALAIVLNVifkKFEIPTIIGYIAAGEIISK--IYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVF 84
Cdd:PRK03562  12 IYLGAAVLIVPIAV---RLGLGSVLGYLIAGCIIGPwgLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  85 LNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLV 164
Cdd:PRK03562  89 GGGALQMVACGGLLGLFCM-LLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 165 DIFSSNNQNI--GQLLLTTLlSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLGA 242
Cdd:PRK03562 168 PLLAASGASTtlGAFALSAL-KVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVFGFGLLMEEVGLSMALGA 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 243 FIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFGIVCGF-LFLYTKKRVA 321
Cdd:PRK03562 247 FLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLLGFLAIKIAMLWLLaRPLGVPRKQR 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 322 LKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNI-RKIANVVEDMTLNTNVVQQSthstlk 400
Cdd:PRK03562 327 RWFAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLVLLdRLEQSRTEEAREADEIDEQQ------ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 401 NHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITN-EAKLE 479
Cdd:PRK03562 401 PRVIIAGFGRFGQIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDpQTSLQ 480

                        490
                 ....*....|
gi 488865219 480 MICQVLASYP 489
Cdd:PRK03562 481 LVELVKEHFP 490
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 21-281 4.63e-58

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 194.40  E-value: 4.63e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   21 IFKKFEIPTIIGYIAAGEII--SKIYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVFLNGSLQMLTCGFVF 98
Cdd:TIGR00932  10 LSRRLGIPSVLGYLLAGVLIgpSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQVLVPGVLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   99 MLLAIEILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLVDIFSSNNQNIGQLL 178
Cdd:TIGR00932  90 GLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLLATSASTEHVAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  179 LTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLGAFIAGALIAETKYKHKI 258
Cdd:TIGR00932 170 ALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMALGAFLAGVVLSESEYRHKL 249

                         250       260
                  ....*....|....*....|...
gi 488865219  259 EADLIPFRDLLLGLFFITVGMQI 281
Cdd:TIGR00932 250 ESDLEPIGGVLLPLFFISVGMSV 272
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 8-371 6.38e-39

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 146.25  E-value: 6.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219    8 FLITAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIYHLSGKGE---ITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVF 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdedLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   85 LNGSLQMLTCGFVF-MLLAIEILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLL 163
Cdd:pfam00999  81 LLALLGVLIPFVLIgLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  164 VDIFSSNNQNIGQLLLTTLLSAVILIALLFF--IGKYLVDRIFRLIIRasSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:pfam00999 161 LLALAQGVGGGSDLGWLLLIFLVVAVGGLLLglLIGWLLRLITRFTDD--DRELEVLLVLLLALLAALLAEALGVSGILG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  242 AFIAGALIAETKYKHKIEADLIPFR-DLLLGLFFITVGMQIQLHIVAQ-NWFIICVLTLLIMGLKFGIVCGFLFLYTK-K 318
Cdd:pfam00999 239 AFLAGLVLSEYPFANKLSEKLEPFGyGLFNPLFFVLVGLSLDLSSLLLsVWILVLLALVAILLGRFLGVFLLLRLLGLsL 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488865219  319 RVALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVL 371
Cdd:pfam00999 319 REALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITL 371
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 4-498 1.54e-94

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 298.81  E-value: 1.54e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   4 FLEIFLItAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIY--HLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQ 81
Cdd:COG4651    7 ITTIALI-LGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTpgLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAVRK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  82 EVFLNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLL 161
Cdd:COG4651   86 IALPGALLQIALTTLLGFGIAL-LLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLAVVLML 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 162 LLVDIFSSNNQNIGQLLLTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:COG4651  165 VLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALFGLSFALG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 242 AFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFgIVCGFLFLYTK--KR 319
Cdd:COG4651  245 AFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKP-LIAFLIVLALGypLR 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 320 VALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVEDMTLNTNVVQQS--THS 397
Cdd:COG4651  324 TALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAARLERDrpEES 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 398 TLKNHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITNEAK 477
Cdd:COG4651  404 DLVVHVVVVGGGGGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLELLAALLAAAAIAVVAIPAAAA 483

                        490       500
                 ....*....|....*....|.
gi 488865219 478 LEMICQVLASYPKPIDTIIHV 498
Cdd:COG4651  484 ALLLIAAARRALPLLIIIARA 504
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 1-382 7.07e-88

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 275.87  E-value: 7.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   1 MDNFLEIFLITAALAIVLNVIFKKFEIPTIIGYIAAGEIISK--IYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIA 78
Cdd:COG0475    2 LASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPsgLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  79 MKQEVFLNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVI 158
Cdd:COG0475   82 MGRRALGIGLLQVLLPFLLGFLLAL-LLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 159 PLLLLVDIFSSNNQNIGQLLLTtLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSY 238
Cdd:COG0475  161 LLLALVPALAGGGSVAGSLLLA-LLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLAAALAELLGLSA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 239 SLGAFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFGIVCGFLFLY-TK 317
Cdd:COG0475  240 ALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAIVGKLLGAYLAARLFgLS 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488865219 318 KRVALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVE 382
Cdd:COG0475  320 RREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLAERAK 384
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 7-489 2.59e-76

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 252.61  E-value: 2.59e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   7 IFLITAALAIVLNVifkKFEIPTIIGYIAAGEIISK--IYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVF 84
Cdd:PRK03562  12 IYLGAAVLIVPIAV---RLGLGSVLGYLIAGCIIGPwgLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRLWKLRRSIF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  85 LNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLV 164
Cdd:PRK03562  89 GGGALQMVACGGLLGLFCM-LLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAIPLVAMI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 165 DIFSSNNQNI--GQLLLTTLlSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLGA 242
Cdd:PRK03562 168 PLLAASGASTtlGAFALSAL-KVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVFGFGLLMEEVGLSMALGA 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 243 FIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFGIVCGF-LFLYTKKRVA 321
Cdd:PRK03562 247 FLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLLGFLAIKIAMLWLLaRPLGVPRKQR 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 322 LKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNI-RKIANVVEDMTLNTNVVQQSthstlk 400
Cdd:PRK03562 327 RWFAVLLGQGGEFAFVVFGAAQMANVLEPEWAKLLTLAVALSMAATPLLLVLLdRLEQSRTEEAREADEIDEQQ------ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 401 NHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITN-EAKLE 479
Cdd:PRK03562 401 PRVIIAGFGRFGQIVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDpQTSLQ 480

                        490
                 ....*....|
gi 488865219 480 MICQVLASYP 489
Cdd:PRK03562 481 LVELVKEHFP 490
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 7-483 9.89e-72

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 239.93  E-value: 9.89e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   7 IFLITAALAIVlnvIFKKFEIPTIIGYIAAGEIISK--IYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVF 84
Cdd:PRK03659  12 LFLFAAVVAVP---LAQRLGIGAVLGYLLAGIAIGPwgLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  85 LNGSLQMLTCGFVFMLLAIeILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLV 164
Cdd:PRK03659  89 GVGAAQVLLSAAVLAGLLM-LTDFSWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 165 DIF---SSNNQNIGQLLLTTLLSAVILIAllffiGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:PRK03659 168 PLLagsADEHFDWMKIGMKVLAFAGMLIG-----GRYLLRPLFRFIAASGVREVFTAAALLLVLGSALFMDALGLSMALG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 242 AFIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIMGLKFGIVCGFLFLY-TKKRV 320
Cdd:PRK03659 243 TFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGVLYTHLLWVLISVVVLVAVKGLVLYLLARLYgLRSSE 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 321 ALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIA----NVVEDMTLNTNVVQQsth 396
Cdd:PRK03659 323 RMQFAGVLSQGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLSMMTTPLLMKLIDKWLarrlNGPEEEDEKPWVEDD--- 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 397 stlKNHLVIFGYGRLGQEI-----VQKIKNTgvpylVLESDLNLVELGISRGENVVFANAAQEETLKIANiTECAVAIVT 471
Cdd:PRK03659 400 ---KPQVIIVGFGRFGQVIgrllmANKMRIT-----VLERDISAVNLMRKYGYKVYYGDATQLELLRAAG-AEKAEAIVI 470

                        490
                 ....*....|....*.
gi 488865219 472 ITNEAKLEM----ICQ 483
Cdd:PRK03659 471 TCNEPEDTMkiveLCQ 486
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 21-281 4.63e-58

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 194.40  E-value: 4.63e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   21 IFKKFEIPTIIGYIAAGEII--SKIYHLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVFLNGSLQMLTCGFVF 98
Cdd:TIGR00932  10 LSRRLGIPSVLGYLLAGVLIgpSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQVLVPGVLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   99 MLLAIEILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLLVDIFSSNNQNIGQLL 178
Cdd:TIGR00932  90 GLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLLATSASTEHVAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  179 LTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLANYFGFSYSLGAFIAGALIAETKYKHKI 258
Cdd:TIGR00932 170 ALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMALGAFLAGVVLSESEYRHKL 249

                         250       260
                  ....*....|....*....|...
gi 488865219  259 EADLIPFRDLLLGLFFITVGMQI 281
Cdd:TIGR00932 250 ESDLEPIGGVLLPLFFISVGMSV 272
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 13-474 7.89e-45

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 166.43  E-value: 7.89e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  13 ALAIVLNVIFKKFEIPTIIGYIAAGEIISKIY--HLSGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVFLNGSLQ 90
Cdd:PRK10669  16 VLAFILGMLANRLRISPLVGYLLAGVLAGPFTpgFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKSIAIPGAIAQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  91 MLTCGFVFMLLAiEILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIA-VIPLLLL---VDI 166
Cdd:PRK10669  96 IAVATLLGMALS-AVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDLVmVLTLVLLpavAGM 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 167 FSSNNQNIGQL---LLTTLLSAVILIALLFFIGKYLVDRIFRLIIRASSQEIFISTILFMVIGASFLA-NYFGFSYSLGA 242
Cdd:PRK10669 175 MEQGDVGFATLavdLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALGIAFGAvELFDVSFALGA 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 243 FIAGALIAETKYKHKIEADLIPFRDLLLGLFFITVGMQIQLHIVAQNWF-IICVLTLLIMGLKFGIVCGFLFLYTKKRVA 321
Cdd:PRK10669 255 FFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLaVLATLAIIVFGKSLAAFFLVRLFGHSRRTA 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 322 LKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVEdmTLNTNVVQQSTHST--- 398
Cdd:PRK10669 335 LTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLFTLLERYLAKTE--TLEEQTLEEAIEEEkqi 412

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488865219 399 ---LKNHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITN 474
Cdd:PRK10669 413 pvdICNHALLVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERGIRAVLGNAANEEIMQLAHLDCARWLLLTIPN 491
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 8-371 6.38e-39

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 146.25  E-value: 6.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219    8 FLITAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIYHLSGKGE---ITHIAEFGIVFLMFTIGLEFSFKHLIAMKQEVF 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdedLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   85 LNGSLQMLTCGFVF-MLLAIEILGLGDKSATIVGFALALSSTAVVLKILNDNGDINEQYGRKALGILLFQDIAVIPLLLL 163
Cdd:pfam00999  81 LLALLGVLIPFVLIgLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  164 VDIFSSNNQNIGQLLLTTLLSAVILIALLFF--IGKYLVDRIFRLIIRasSQEIFISTILFMVIGASFLANYFGFSYSLG 241
Cdd:pfam00999 161 LLALAQGVGGGSDLGWLLLIFLVVAVGGLLLglLIGWLLRLITRFTDD--DRELEVLLVLLLALLAALLAEALGVSGILG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  242 AFIAGALIAETKYKHKIEADLIPFR-DLLLGLFFITVGMQIQLHIVAQ-NWFIICVLTLLIMGLKFGIVCGFLFLYTK-K 318
Cdd:pfam00999 239 AFLAGLVLSEYPFANKLSEKLEPFGyGLFNPLFFVLVGLSLDLSSLLLsVWILVLLALVAILLGRFLGVFLLLRLLGLsL 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488865219  319 RVALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIVTMIITPFVL 371
Cdd:pfam00999 319 REALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITL 371
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
277-490 8.75e-25

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 104.04  E-value: 8.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 277 VGMQIQLHIVAQNWFIICVLTLLIMGLKFGIVCGFLFLYTKKRVALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQIL 356
Cdd:COG1226    1 LGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 357 IVVSIVTMIITPFVLNNIRKIANVVEDMTLNTNVVQQSTHSTLKNHLVIFGYGRLGQEIVQKIKNTGVPYLVLESDLNLV 436
Cdd:COG1226   81 LLLVLLLLLLLLLLLLLLALLLLLLALAAREEEAEAAEDAIDLEGHVIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERV 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488865219 437 ELGISRGENVVFANAAQEETLKIANITECAVAIVTITN-EAKLEMICQVLASYPK 490
Cdd:COG1226  161 EELRRFGIKVYYGDATRPDVLEAAGIERARALVVAIDDpEAALRIVELARELNPD 215
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
3-301 1.45e-14

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 76.16  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   3 NFLEIFLITAALAIVLNVIFKKFEIPTIIGYIAAGEIISKIYHL---SGKGEITHIAEFGIVFLMFTIGLEFSFKHLIAM 79
Cdd:COG0025    2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGPGLGLeldPELGDLEPLLELFLPPLLFEAALNLDLRELRRN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  80 KQEVFLNGSLQMLTCGFVFMLLAIEILGLGDKSATIVGFALALSSTAVVLKILNDNGDineqygRKALGILL-----FQD 154
Cdd:COG0025   82 GRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGV------PKRLRTILegeslLND 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 155 IAVIPLL-LLVDIFSSNNQNIGQLLLTTLLSAVILIALLFFIGkYLVDRIFRLiIRASSQEIFIStiLFMVIGASFLANY 233
Cdd:COG0025  156 ATALVLFvLALAAALGGGFSLGEALLDFLLAILGGILVGLLLG-WLLGRLLRR-LPDPLLEILLT--LALPFLAYLLAEA 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488865219 234 FGFSYSLGAFIAGALIAETKYKHKIEADLIPFRD-------LLLGLFFITVGMQIQLHIVAQNWFIICVLTLLIM 301
Cdd:COG0025  232 LHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEfwetlefLLNSLLFVLLGAQLPLILLGALGLGGILLVLLAL 306
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 347-532 3.90e-10

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 60.85  E-value: 3.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 347 MLDVETAQILIVVSIVTMIITPFVLNNIRKIANVVEDMTLNTNVVQQSTHSTLKNHLVIFGYGRLGQEIVQKIKNTGVPY 426
Cdd:COG0569   42 LLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLEALRRRRMERGIKKLKMHVIIIGAGRVGRSLARELEEEGHDV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 427 LVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITNEAKLEMICQVLASYpKPIDTIIHVN--GSLEK 504
Cdd:COG0569  122 VVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDDEANILACLLAKEL-GVPRIIARANdpEYADL 200

                        170       180
                 ....*....|....*....|....*...
gi 488865219 505 MLFSSIDeniRIVRSEKVIARNLVQEAL 532
Cdd:COG0569  201 LERLGAD---VVISPERLAARRIARLLL 225
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 1-370 2.68e-09

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 59.90  E-value: 2.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219   1 MDNFLEIFLITAALAIV----LNVIFKKFEIPTIIGYIAAGEII------------SKIYHLSGKGEITHIAEFGIVFLM 64
Cdd:PLN03159  37 LDFSLPLFILQLTLVVVttrlLVFILKPFRQPRVISEILGGVILgpsvlgqsevfaNTIFPLRSVMVLETMANLGLLYFL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  65 FTIGLEfsfkhliaMKQEVFLNGSLQMLTCGFVFMLLAIeILGLG------------DKSATIVGFALALSSTA--VVLK 130
Cdd:PLN03159 117 FLVGVE--------MDISVIRRTGKKALAIAIAGMALPF-CIGLAfsfifhqvsrnvHQGTFILFLGVALSVTAfpVLAR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 131 ILNDNGDINEQYGRKALGILLFQDI-AVIPLLLLVDIFSSNNQNIGQLLLttLLSAVILIALLFFIGKYLVDRIFRLIIR 209
Cdd:PLN03159 188 ILAEIKLINTELGRIAMSAALVNDMcAWILLALAIALAENDSTSLASLWV--LLSSVAFVLFCFYVVRPGIWWIIRRTPE 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 210 ASS-QEIFISTILFMVIGASFLANYFGFSYSLGAFIAGALIAETKYKHKIEADLIPF-RDLLLGLFFITVGMQIQLHIVa 287
Cdd:PLN03159 266 GETfSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFvSGLLLPLFFAISGLKTNVTKI- 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219 288 QNWFIICVLTLLIMGLKFGIVCGFL---FLYTKK-RVALKTAFSIAQVGEFALAIFSLLQAKSMLDVETAQILIVVSIV- 362
Cdd:PLN03159 345 QGPATWGLLVLVIIMASAGKIMGTIiiaFFYTMPfREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAm 424


                 ....*...
gi 488865219 363 TMIITPFV 370
Cdd:PLN03159 425 TALITPVV 432
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 404-499 3.72e-08

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 51.76  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488865219  404 VIFGYGRLGQEIVQKIKNTGvPYLVLESDLNLVELGISRGENVVFANAAQEETLKIANITECAVAIVTITNEAKLEMICQ 483
Cdd:pfam02254   2 IIIGYGRVGRSLAEELSEGG-DVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILIVL 80

                          90
                  ....*....|....*.
gi 488865219  484 VLASYPKPIDTIIHVN 499
Cdd:pfam02254  81 LARELNPDKKIIARAN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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