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Conserved domains on  [gi|488866712|ref|WP_002778951|]
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MULTISPECIES: P-loop NTPase fold protein [Campylobacter]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KAP_NTPase super family cl46386
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
22-123 1.69e-22

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


The actual alignment was detected with superfamily member COG4928:

Pssm-ID: 480726  Cd Length: 386  Bit Score: 91.13  E-value: 1.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866712  22 KKEEDLFSRNSVAEQLNTIIKNYKEEDSITFGIIGDWGSGKTSFVNMTLEDFKDDENFIIVKFNPWNISTRKKLISDFFT 101
Cdd:COG4928    2 ETEEDLLGRKKYAESLANLIKSSDADEPLVIGLDGEWGSGKTSFLNLIEKELESNEKVIVVYFNAWLYDGEEDLLAALLS 81
                         90       100
                 ....*....|....*....|...
gi 488866712 102 TLAKEIRKASFPKFKI-KNLKKY 123
Cdd:COG4928   82 EIAAELEKKKKKDKKAaKKLKKY 104
 
Name Accession Description Interval E-value
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
22-123 1.69e-22

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 91.13  E-value: 1.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866712  22 KKEEDLFSRNSVAEQLNTIIKNYKEEDSITFGIIGDWGSGKTSFVNMTLEDFKDDENFIIVKFNPWNISTRKKLISDFFT 101
Cdd:COG4928    2 ETEEDLLGRKKYAESLANLIKSSDADEPLVIGLDGEWGSGKTSFLNLIEKELESNEKVIVVYFNAWLYDGEEDLLAALLS 81
                         90       100
                 ....*....|....*....|...
gi 488866712 102 TLAKEIRKASFPKFKI-KNLKKY 123
Cdd:COG4928   82 EIAAELEKKKKKDKKAaKKLKKY 104
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
30-124 2.92e-14

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 67.41  E-value: 2.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866712   30 RNSVAEQLNTIIKNYKEEDSITFGIIGDWGSGKTSFVNMTLEDFKDDEN-FIIVKFNPWNISTRKKLISDFFTTLAKEI- 107
Cdd:pfam07693   1 RDPYAENLAKLLVDSSPAPGLVIGLYGQWGSGKTSFLNLLEKELNEFNEeFIIVYFNPWSFSGQDDLDAELFSALADALe 80
                          90
                  ....*....|....*..
gi 488866712  108 RKASFPKFKIKNLKKYI 124
Cdd:pfam07693  81 EEYSQLATKLLIGKKLP 97
 
Name Accession Description Interval E-value
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
22-123 1.69e-22

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 91.13  E-value: 1.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866712  22 KKEEDLFSRNSVAEQLNTIIKNYKEEDSITFGIIGDWGSGKTSFVNMTLEDFKDDENFIIVKFNPWNISTRKKLISDFFT 101
Cdd:COG4928    2 ETEEDLLGRKKYAESLANLIKSSDADEPLVIGLDGEWGSGKTSFLNLIEKELESNEKVIVVYFNAWLYDGEEDLLAALLS 81
                         90       100
                 ....*....|....*....|...
gi 488866712 102 TLAKEIRKASFPKFKI-KNLKKY 123
Cdd:COG4928   82 EIAAELEKKKKKDKKAaKKLKKY 104
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
30-124 2.92e-14

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 67.41  E-value: 2.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488866712   30 RNSVAEQLNTIIKNYKEEDSITFGIIGDWGSGKTSFVNMTLEDFKDDEN-FIIVKFNPWNISTRKKLISDFFTTLAKEI- 107
Cdd:pfam07693   1 RDPYAENLAKLLVDSSPAPGLVIGLYGQWGSGKTSFLNLLEKELNEFNEeFIIVYFNPWSFSGQDDLDAELFSALADALe 80
                          90
                  ....*....|....*..
gi 488866712  108 RKASFPKFKIKNLKKYI 124
Cdd:pfam07693  81 EEYSQLATKLLIGKKLP 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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