|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
2-457 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 746.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 2 QQEHFDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKH----KKIDEQILTE 77
Cdd:PRK08506 1 MDELYDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKlpkdKKIDEEILLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 78 IIATPSIIDLPAYVNELREKSIKRQLLSFAHLLPTR-INDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLEE 156
Cdd:PRK08506 81 ILATNPIDNIEAYVEEIKEKSIKRELLSLANTIPEQaVEEDQKSSDILDEVERELYSITNGSNSEDFKDSKEVIESTMEH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 FKKQKSLENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRML 236
Cdd:PRK08506 161 IKKQKRLGNKDIIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALNQDKGVAFFSLEMPAEQLMLRML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 237 SAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMSNSNF 316
Cdd:PRK08506 241 SAKTSIPLQNLRTGDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVIDYLQLMSGSGNF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 317 NDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEKEREN 396
Cdd:PRK08506 321 KDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYKEREEKEKEK 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488868666 397 KAKAEGKPYQRNFIPNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVDKP---RFESVEFQE 457
Cdd:PRK08506 401 KAKKEGKEERRIHFQNKSIEEAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPiesHYEEGEETK 464
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
7-448 |
7.41e-174 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 494.25 E-value: 7.41e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEI 78
Cdd:TIGR00665 4 NIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLvtvaEELEKDGELEEvgglAYLAEL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 IA-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRIND-NRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLEE 156
Cdd:TIGR00665 84 ASnVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDpTGDVEELLDEAEQKIFEIAESRTSKGFKSIKEILKEAVEE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 FKKQKSLENkSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQRM 235
Cdd:TIGR00665 164 IEELYERKG-GITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAaIKEGKPVAFFSLEMSAEQLVMRM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 236 LSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKaQEESIGLCVIDYIGLMMSNSN 315
Cdd:TIGR00665 243 LSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLK-REHGLGLIVIDYLQLMSGSGR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 316 FNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdekere 395
Cdd:TIGR00665 322 SENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPD------ 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 488868666 396 nkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVDKP 448
Cdd:TIGR00665 396 ----------------SEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
7-446 |
1.49e-170 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 485.74 E-value: 1.49e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEI 78
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLvtvaEELEKRGELEEvggaAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 IA-TPSIIDLPAYVNELREKSIKRQLLSFAhllpTRI-----NDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSE 152
Cdd:COG0305 81 AEnVPSAANIEYYARIVKEKALLRRLIEAG----TEIvelayDEDEDVDELLDEAEQKIFEIAEKRSSKGFVSISDILKE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 153 LLEEFKKQKSlENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQI 231
Cdd:COG0305 157 ALERIEELYK-NGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAaIKEGKPVAIFSLEMSAEQL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 232 MQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEEsIGLCVIDYIGLMM 311
Cdd:COG0305 236 VMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 312 SNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDE 391
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 488868666 392 KEREnkakaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:COG0305 395 DKGI----------------------AEIIIAKQRNGPTGTVKLAFDGEYTRFEN 427
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
170-446 |
3.17e-133 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 384.08 E-value: 3.17e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 170 GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKIL 248
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAaVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 249 TADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEEsIGLCVIDYIGLMMSNSNFNDRHLQVSEISR 328
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEISR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 329 GLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEKERenkakaegkpyqrn 408
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGK-------------- 225
|
250 260 270
....*....|....*....|....*....|....*...
gi 488868666 409 fipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:pfam03796 226 ---------AEIIIAKQRNGPTGTVKLAFLGEYTRFEN 254
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
170-446 |
3.78e-121 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 353.74 E-value: 3.78e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 170 GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVL-RQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKIL 248
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIAlDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 249 TADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMSNSNFNDRHLQVSEISR 328
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEISR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 329 GLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdekerenkakaegkpyqrn 408
Cdd:cd00984 161 SLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKD------------------- 221
|
250 260 270
....*....|....*....|....*....|....*...
gi 488868666 409 fipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:cd00984 222 ---SEDKGIAEIIIAKNRNGPTGTVYLAFNPEYTRFTD 256
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
6-437 |
3.46e-107 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 324.65 E-value: 3.46e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 6 FDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIdEQI-----LT 76
Cdd:NF040583 3 YSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLitlsESLEQQGQL-EQVggfayLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 77 EIIA-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRINDNRA-VSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELL 154
Cdd:NF040583 82 ELSKnTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRAdIADLLEQAEQRLFDIAEQAEPQQEVTLIEGLETLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENkSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQ--DKGVVMFSLEMPAAQIM 232
Cdd:NF040583 162 SELELRCQSGN-GITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRGkpDKVVQIYSLEMPTEQLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 233 QRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYS--KKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLM 310
Cdd:NF040583 241 MRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTdwKDRLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDYLQLM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 311 MSNSNFNdRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQd 390
Cdd:NF040583 321 RCPGQEN-RTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVYNPN- 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 488868666 391 ekerenkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLF 437
Cdd:NF040583 399 ---------------------TPDKGIAEIIIGKQRQGPTGTVKVQF 424
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
188-355 |
1.44e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.89 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 188 GELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLsaktsiplqkiltadlndnewerigdacnyy 267
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLL------------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 268 skkKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMmsNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQL 347
Cdd:smart00382 51 ---LIIVGGKKASGSGELRLRLALALARKLKPDVLILDEITSL--LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTND 125
|
....*...
gi 488868666 348 NRSLEQRA 355
Cdd:smart00382 126 EKDLGPAL 133
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08506 |
PRK08506 |
replicative DNA helicase; Provisional |
2-457 |
0e+00 |
|
replicative DNA helicase; Provisional
Pssm-ID: 236278 [Multi-domain] Cd Length: 472 Bit Score: 746.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 2 QQEHFDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKH----KKIDEQILTE 77
Cdd:PRK08506 1 MDELYDLDIERAVLSSILFSPDKFEEIASVLEPKDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKlpkdKKIDEEILLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 78 IIATPSIIDLPAYVNELREKSIKRQLLSFAHLLPTR-INDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLEE 156
Cdd:PRK08506 81 ILATNPIDNIEAYVEEIKEKSIKRELLSLANTIPEQaVEEDQKSSDILDEVERELYSITNGSNSEDFKDSKEVIESTMEH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 FKKQKSLENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRML 236
Cdd:PRK08506 161 IKKQKRLGNKDIIGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALNQDKGVAFFSLEMPAEQLMLRML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 237 SAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMSNSNF 316
Cdd:PRK08506 241 SAKTSIPLQNLRTGDLDDDEWERLSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAVIDYLQLMSGSGNF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 317 NDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEKEREN 396
Cdd:PRK08506 321 KDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRADKRPMLSDLRESGAIEQDADIILFVYRDDVYKEREEKEKEK 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488868666 397 KAKAEGKPYQRNFIPNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVDKP---RFESVEFQE 457
Cdd:PRK08506 401 KAKKEGKEERRIHFQNKSIEEAEIIIGKNRNGPTGTVKLRFQKEFTRFVDKPiesHYEEGEETK 464
|
|
| DnaB |
TIGR00665 |
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ... |
7-448 |
7.41e-174 |
|
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273206 [Multi-domain] Cd Length: 432 Bit Score: 494.25 E-value: 7.41e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEI 78
Cdd:TIGR00665 4 NIEAEQAVLGAILLDNEAIDDVAEILKPEDFYRPAHRLIFQAILDLYEKGEPIDLvtvaEELEKDGELEEvgglAYLAEL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 IA-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRIND-NRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLEE 156
Cdd:TIGR00665 84 ASnVPSAANIEYYAEIVKEKAILRRLIQAGTEIVELAYDpTGDVEELLDEAEQKIFEIAESRTSKGFKSIKEILKEAVEE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 FKKQKSLENkSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQRM 235
Cdd:TIGR00665 164 IEELYERKG-GITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAaIKEGKPVAFFSLEMSAEQLVMRM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 236 LSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKaQEESIGLCVIDYIGLMMSNSN 315
Cdd:TIGR00665 243 LSSESRVDSQKLRTGRLSDEDWEKLTEAAGELSEAPLYIDDTPGLTITELRAKARRLK-REHGLGLIVIDYLQLMSGSGR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 316 FNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdekere 395
Cdd:TIGR00665 322 SENRQQEVSEISRSLKALAKELNVPVIALSQLSRSVEQREDKRPQLSDLRESGSIEQDADIVMFLYRDEYYNPD------ 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 488868666 396 nkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVDKP 448
Cdd:TIGR00665 396 ----------------SEDKGIAEIIIAKQRNGPTGTVKLAFLGEYTRFENLA 432
|
|
| DnaB |
COG0305 |
Replicative DNA helicase [Replication, recombination and repair]; |
7-446 |
1.49e-170 |
|
Replicative DNA helicase [Replication, recombination and repair];
Pssm-ID: 440074 [Multi-domain] Cd Length: 429 Bit Score: 485.74 E-value: 1.49e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEI 78
Cdd:COG0305 1 NIEAEQAVLGALLLDNDALDEVADILKPEDFYRPAHRLIFEAILDLYERGEPIDLvtvaEELEKRGELEEvggaAYLAEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 IA-TPSIIDLPAYVNELREKSIKRQLLSFAhllpTRI-----NDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSE 152
Cdd:COG0305 81 AEnVPSAANIEYYARIVKEKALLRRLIEAG----TEIvelayDEDEDVDELLDEAEQKIFEIAEKRSSKGFVSISDILKE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 153 LLEEFKKQKSlENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQI 231
Cdd:COG0305 157 ALERIEELYK-NGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAaIKEGKPVAIFSLEMSAEQL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 232 MQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEEsIGLCVIDYIGLMM 311
Cdd:COG0305 236 VMRLLSSEARIDSSKLRTGKLSDEDWERLSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 312 SNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDE 391
Cdd:COG0305 315 GSGRSENRQQEISEISRSLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGSIEQDADVVMFLYRDEYYNPDSE 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 488868666 392 KEREnkakaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:COG0305 395 DKGI----------------------AEIIIAKQRNGPTGTVKLAFDGEYTRFEN 427
|
|
| DnaB_C |
pfam03796 |
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
170-446 |
3.17e-133 |
|
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 427509 [Multi-domain] Cd Length: 254 Bit Score: 384.08 E-value: 3.17e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 170 GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKIL 248
Cdd:pfam03796 1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAaVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 249 TADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEEsIGLCVIDYIGLMMSNSNFNDRHLQVSEISR 328
Cdd:pfam03796 81 TGQLTDEDWEKLAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGENRQQEISEISR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 329 GLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEKERenkakaegkpyqrn 408
Cdd:pfam03796 160 SLKALAKELNVPVIALSQLSRAVEQRTDKRPQLSDLRESGAIEQDADVVMFLYRDEYYNPKEPEGK-------------- 225
|
250 260 270
....*....|....*....|....*....|....*...
gi 488868666 409 fipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:pfam03796 226 ---------AEIIIAKQRNGPTGTVKLAFLGEYTRFEN 254
|
|
| PRK05748 |
PRK05748 |
replicative DNA helicase; Provisional |
7-451 |
2.65e-125 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180232 [Multi-domain] Cd Length: 448 Bit Score: 371.21 E-value: 2.65e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEI 78
Cdd:PRK05748 13 SIEAEQAVLGAIFLDPDALITVSEYLSPDDFYRHAHRLIFRAMLKLSDRGEPIDVvtvtEILDDQGDLEEvgglSYLAEL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 I-ATPSIIDLPAYVNELREKSIKRQLLSFAhllpTRINDN-----RAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSE 152
Cdd:PRK05748 93 AnSVPTAANIEYYAKIVAEKAMLRRLIRTA----TEIANDayepeDDADEILDEAEKKIFEVSERRNKSGFKNIKDVLVK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 153 L---LEEFKKQKSlenkSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPA 228
Cdd:PRK05748 169 AydrIEMLHNQTG----DITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVaTKTDKNVAIFSLEMGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 229 AQIMQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIG 308
Cdd:PRK05748 245 ESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKLTIAMGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGLGLILIDYLQ 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 309 LMMSNSNFND-RHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYr 387
Cdd:PRK05748 325 LIQGSGRSGEnRQQEVSEISRSLKALAKELKVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDYY- 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488868666 388 eqdEKERENKAKaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVDKPRFE 451
Cdd:PRK05748 404 ---DEETENKNT------------------IEIIIAKQRNGPVGTVELAFQKEYNKFVNLARRE 446
|
|
| DnaB_C |
cd00984 |
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ... |
170-446 |
3.78e-121 |
|
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.
Pssm-ID: 410864 [Multi-domain] Cd Length: 256 Bit Score: 353.74 E-value: 3.78e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 170 GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVL-RQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKIL 248
Cdd:cd00984 1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIAlDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 249 TADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMSNSNFNDRHLQVSEISR 328
Cdd:cd00984 81 TGRLDDEDWERLTAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENRQQEVAEISR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 329 GLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdekerenkakaegkpyqrn 408
Cdd:cd00984 161 SLKALAKELNVPVIALSQLNRGVESRTDKRPMLSDLRESGSIEQDADVVIFLYRDEYYDKD------------------- 221
|
250 260 270
....*....|....*....|....*....|....*...
gi 488868666 409 fipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:cd00984 222 ---SEDKGIAEIIIAKNRNGPTGTVYLAFNPEYTRFTD 256
|
|
| phage_DnaB |
TIGR03600 |
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or ... |
8-437 |
8.47e-108 |
|
phage replicative helicase, DnaB family, HK022 subfamily; Members of this family are phage (or prophage-region) homologs of the bacterial homohexameric replicative helicase DnaB. Some phage may rely on host DnaB, while others encode their own verions. This model describes the largest phage-specific clade among the close homologs of DnaB, but there are, or course, other DnaB homologs from phage that fall outside the scope of this model. [Mobile and extrachromosomal element functions, Prophage functions]
Pssm-ID: 274672 [Multi-domain] Cd Length: 420 Bit Score: 325.51 E-value: 8.47e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 8 LDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKH---KKIDEQI-----LTEII 79
Cdd:TIGR03600 2 IEAEQAVLGGLLLDNDFIERVMAILKPEHFYSQDHRIIFEAMLDMFAENRPVDPLTLADKleaEGEAEKVgglayLAEIS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 80 -ATPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRI--NDNRAVSEISDEIGKEIFNITNrvnTNDIKDIEIVLSELLEE 156
Cdd:TIGR03600 82 nNTPSAANISSYARIVREKAKERKLIAACQRIITLAcsPDGGTAEQKVEEAQAALLALTM---SDGQEDGFVTFGEVLED 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 F--KKQKSLENKSVI-GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIM 232
Cdd:TIGR03600 159 VvrDLDKRFNPKGELtGLSTGLPKLDRLTNGLVKGDLIVIGARPSMGKTTLALNIAENVaLREGKPVLFFSLEMSAEQLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 233 QRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMS 312
Cdd:TIGR03600 239 ERLLASKSGINTGNIRTGRFNDSEFNRLLNAVDRLSEKDLYIDDTGGLTVAQIRSIARRIKRKKGGLDLIVVDYIQLMAP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 313 NSNfNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEK 392
Cdd:TIGR03600 319 ARG-RDRNEELGGISRGLKALAKELDVPVVLLAQLNRGSEKRTDKRPIMSDLRDSGAIEQDADVIGLIHREGYYDAREPP 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 488868666 393 EREnkakaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLF 437
Cdd:TIGR03600 398 AGI----------------------AELILAKNRHGPTGTVELLF 420
|
|
| dnaB_SPI-7_type |
NF040583 |
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a ... |
6-437 |
3.46e-107 |
|
SPI-7-type island replicative DNA helicase; Members of this family are DnaB-PI, a pathogenicity island (PI) variant of the replicative DNA helicase DnaB. Members are found with other conjugative element replication proteins such as ParA, ParB in genetic islands whose core proteins (but not cargo proteins) are shared with the Salmonella typhi SPI-7 island.
Pssm-ID: 468557 [Multi-domain] Cd Length: 434 Bit Score: 324.65 E-value: 3.46e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 6 FDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIdEQI-----LT 76
Cdd:NF040583 3 YSVEAEQSVLGGLMLDNDRWDDVALLLAADDFYSRAHRIIFRAMARLVSAGQPIDLitlsESLEQQGQL-EQVggfayLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 77 EIIA-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRINDNRA-VSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELL 154
Cdd:NF040583 82 ELSKnTPSAANIVAYAEIVAEYSRARQLLALGHDLSADASAPRAdIADLLEQAEQRLFDIAEQAEPQQEVTLIEGLETLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENkSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQ--DKGVVMFSLEMPAAQIM 232
Cdd:NF040583 162 SELELRCQSGN-GITGTPTGFAELDEMTCGLQPGDLILLAARPSMGKTALALAFCLGALRGkpDKVVQIYSLEMPTEQLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 233 QRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYS--KKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLM 310
Cdd:NF040583 241 MRLVSMLGRVPLQRLRSGLLDDEDWARISQAMALLTdwKDRLIIDDTSYLTPALLRARARRNARKYGKPSLIMVDYLQLM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 311 MSNSNFNdRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQd 390
Cdd:NF040583 321 RCPGQEN-RTQEIAEISRSLKALAKEMGCPVLALSQLNRQLESRADKRPNNGDLRDSGALEQDADLIMFIYRDEVYNPN- 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 488868666 391 ekerenkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLF 437
Cdd:NF040583 399 ---------------------TPDKGIAEIIIGKQRQGPTGTVKVQF 424
|
|
| PRK08840 |
PRK08840 |
replicative DNA helicase; Provisional |
8-444 |
8.63e-102 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181562 [Multi-domain] Cd Length: 464 Bit Score: 311.92 E-value: 8.63e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 8 LDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKHKKIDEQI--------LTEII 79
Cdd:PRK08840 24 LEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLERREQLedvggfayLADLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 80 A-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRIND--NRAVSEISDEIGKEIFNITN-RVNTND-IKDIEIVLSELL 154
Cdd:PRK08840 104 KnTPSAANINAYADIVAERALVRNLIGVANEIADAGYDpqGRTSEDLLDMAESKVFAIAEaRTSENEgPQNVDSILEKTL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQ 233
Cdd:PRK08840 184 ERIELLYKTPQDGVTGVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAaMDQDKPVLIFSLEMPAEQLMM 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 234 RMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKK-LFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMS 312
Cdd:PRK08840 264 RMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKnMYIDDSSGLTPTEVRSRARRIAREHGGLSMIMVDYLQLMRV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 313 NSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdek 392
Cdd:PRK08840 344 PALSDNRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYNPD--- 420
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 488868666 393 erenkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCF 444
Cdd:PRK08840 421 -------------------SPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRF 453
|
|
| PRK08006 |
PRK08006 |
replicative DNA helicase DnaB; |
8-444 |
6.60e-97 |
|
replicative DNA helicase DnaB;
Pssm-ID: 181193 [Multi-domain] Cd Length: 471 Bit Score: 299.23 E-value: 6.60e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 8 LDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKHKKIDEQI--------LTEII 79
Cdd:PRK08006 31 IEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFTEMARLQESGSPIDLITLAESLERQGQLdsvggfayLAELS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 80 A-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRIND--NRAVSEISDEIGKEIFNIT-NRVNTND-IKDIEIVLSELL 154
Cdd:PRK08006 111 KnTPSAANISAYADIVRERAVVREMISVANEIADAGYDpqGRTSEDLLDLAESRVFQIAeSRANKDEgPKNIADILDATV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQ 233
Cdd:PRK08006 191 ARIEQLFQQPHDGVTGVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAaMLQDKPVLIFSLEMPGEQIMM 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 234 RMLSAKTSIPLQKILTADLNDNEWERIGDACN-YYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMS 312
Cdd:PRK08006 271 RMLASLSRVDQTRIRTGQLDDEDWARISGTMGiLLEKRNMYIDDSSGLTPTEVRSRARRIFREHGGLSLIMIDYLQLMRV 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 313 NSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDEk 392
Cdd:PRK08006 351 PSLSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRADKRPVNSDLRESGSIEQDADLIMFIYRDEVYHENSD- 429
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 488868666 393 erenkakaegkpyqrnfipnpMQENAEILVGKNRNGPVGVVEVLFLKEKSCF 444
Cdd:PRK08006 430 ---------------------LKGIAEIIIGKQRNGPIGTVRLTFNGQWSRF 460
|
|
| PRK06904 |
PRK06904 |
replicative DNA helicase; Validated |
8-444 |
1.50e-93 |
|
replicative DNA helicase; Validated
Pssm-ID: 136106 [Multi-domain] Cd Length: 472 Bit Score: 290.74 E-value: 1.50e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 8 LDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIDE----QILTEII 79
Cdd:PRK06904 27 IEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLltldQALKTKGKSDEvggfAYLAELS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 80 A-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTRI--NDNRAVSEISDEIGKEIFNITNRVNTND--IKDIEIVLSELL 154
Cdd:PRK06904 107 NnTPSAANILAYADIVREKAILRELISVGNNIAKNAysPKGQDIKDILDEAERDVFSIAEKRTTANegPQNVINLLENTI 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENKS-VIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIM 232
Cdd:PRK06904 187 DKIENLAATPTNNgVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAaMASEKPVLVFSLEMPAEQIM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 233 QRMLSAKTSIPLQKILTA-DLNDNEWERIGDACNYYSKK-KLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLM 310
Cdd:PRK06904 267 MRMLASLSRVDQTKIRTGqNLDQQDWAKISSTVGMFKQKpNLYIDDSSGLTPTELRSRARRVYRENGGLSLIMVDYLQLM 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 311 MSNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQD 390
Cdd:PRK06904 347 RAPGFEDNRTLEIAEISRSLKALAKELKVPVVALSQLNRTLENRGDKRPVNSDLRESGSIEQDADLIMFIYRDEVYNETT 426
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 488868666 391 EkerENKAKaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCF 444
Cdd:PRK06904 427 E---DNKGV------------------AEIIIGKQRNGPIGRVRLAFQGQYSRF 459
|
|
| PRK05595 |
PRK05595 |
replicative DNA helicase; Provisional |
7-446 |
6.20e-93 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235525 [Multi-domain] Cd Length: 444 Bit Score: 288.27 E-value: 6.20e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKHKKIDEQI--------LTEI 78
Cdd:PRK05595 11 SIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLeaaggvtyITEL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 79 IAT-PSIIDLPAYVNELREKSIKRQLL-SFAHLLPTRINDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLEE 156
Cdd:PRK05595 91 SNSiVSTANIQSYIKIVKDKSTLRRLIkSSTEIIENSYNNQDDVEKVIDSAEKKIFDISEKRTTSDFEPLSNVLERGFEQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 FkkQKSLENK-SVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIE-KVLRQDKGVVMFSLEMPAAQIMQR 234
Cdd:PRK05595 171 I--ENLFNNKgETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEyAALREGKSVAIFSLEMSKEQLAYK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 235 MLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAqEESIGLCVIDYIGLMMSNS 314
Cdd:PRK05595 249 LLCSEANVDMLRLRTGNLEDKDWENIARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKI-EHGIDMILIDYLQLMSGGK 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 315 NFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYreqdEKER 394
Cdd:PRK05595 328 GSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEYY----NKET 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 488868666 395 ENKakaegkpyqrnfipnpmqENAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:PRK05595 404 EDK------------------NVAECIIAKQRNGPTGTVKLAWLGQYSKFGN 437
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
7-390 |
1.19e-92 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 299.36 E-value: 1.19e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKIdEQI-----LTE 77
Cdd:PRK07773 27 DLAAEQSVLGGMLLSKEAIARVLERLRPGAFYRPAHQNIYDAILDLYGRGEPADLvtvaAELDRRGLL-ERIggapyLHT 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 78 IIA-TPSIIDLPAYVNELREKSIKRQLLSFAHLLPTR-INDNRAVSEISDEIGKEIFNITNRVNTNDIKDIEIVLSELLE 155
Cdd:PRK07773 106 LIStVPTAANADYYARIVAEKALLRRLIEAGTRIVQYgYAEGADVAEVVDRAQAEIYDVTDRRLSEDFVALEDLLQPTFD 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 156 EFkkQKSLENKSVI-GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIMQ 233
Cdd:PRK07773 186 EI--DAIASSGGLArGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCaIRHRLAVAIFSLEMSKEQLVM 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 234 RMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEEsIGLCVIDYIGLMMSN 313
Cdd:PRK07773 264 RLLSAEAKIKLSDMRSGRMSDDDWTRLARAMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEAN-LGLIVVDYLQLMTSG 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 314 SNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQD-----ADTILFVYRDEVYRE 388
Cdd:PRK07773 343 KKYENRQQEVSEISRHLKLLAKELEVPVVALSQLSRGVEQRTDKRPMLSDLRESGCLTGDtlilrADTGAEVPIGELVGE 422
|
..
gi 488868666 389 QD 390
Cdd:PRK07773 423 RP 424
|
|
| PRK07004 |
PRK07004 |
replicative DNA helicase; Provisional |
8-444 |
2.16e-92 |
|
replicative DNA helicase; Provisional
Pssm-ID: 235907 [Multi-domain] Cd Length: 460 Bit Score: 287.58 E-value: 2.16e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 8 LDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPI-------SISFLKKHKKIDEQILTEIIA 80
Cdd:PRK07004 19 IEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPAdvitvyeALTTSGKAEEVGGLAYLNALA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 81 --TPSIIDLPAYVNELREKSIKRQLLSFA-HLLPTRIN-DNRAVSEISDEIGKEIFNITNR--VNTNDIKDIEIVLSELL 154
Cdd:PRK07004 99 qnTPSAANIRRYAEIVRDRAVLRRLVSVAdEISADAFNpQGKEVRQLLDEAESKVFSIAEEgaRGTQGFLEIGPLLTQVV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKQKSLENKS-VIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQIM 232
Cdd:PRK07004 179 ERIDTLYHTANPSdVTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVaVEYGLPVAVFSMEMPGTQLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 233 QRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMS 312
Cdd:PRK07004 259 MRMLGSVGRLDQHRMRTGRLTDEDWPKLTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQCGKLGLIIIDYLQLMSG 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 313 NSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQdek 392
Cdd:PRK07004 339 SSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRPNKRPVMSDLRESGAIEQDADVILFIYRDEVYNPD--- 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 488868666 393 erenkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCF 444
Cdd:PRK07004 416 -------------------SPDKGTAEIIIGKQRNGPIGPVRLTFLGQYTKF 448
|
|
| PRK08760 |
PRK08760 |
replicative DNA helicase; Provisional |
11-444 |
3.25e-90 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181547 [Multi-domain] Cd Length: 476 Bit Score: 282.19 E-value: 3.25e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 11 ERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISI----SFLKKHKKI----DEQILTEIIAT- 81
Cdd:PRK08760 40 EQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPFDAvtlgEWFESQGKLeqvgDGAYLIELASTt 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 82 PSIIDLPAYVNELREKSIKRQLLSFAHLLptrINDN-----RAVSEISDEIGKEIFNITN---RVNTnDIKDIEIVLSEL 153
Cdd:PRK08760 120 PSAANIAAYAEIVRDKAVLRQLIEVGTTI---VNDGfqpegRESIELLASAEKAVFKIAEagaRGRT-DFVAMPGALKDA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 154 LEEFkkQKSLENKS-VIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSLEMPAAQI 231
Cdd:PRK08760 196 FEEL--RNRFENGGnITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAaIKSKKGVAVFSMEMSASQL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 232 MQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKaQEESIGLCVIDYIGLMM 311
Cdd:PRK08760 274 AMRLISSNGRINAQRLRTGALEDEDWARVTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLK-REHDLGLIVIDYLQLMS 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 312 SNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYREQDe 391
Cdd:PRK08760 353 VPGNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRTDKRPVMADLRESGAIEQDADMIVFIYRDDYYNKEN- 431
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 488868666 392 kerenkakaegkpyqrnfipNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCF 444
Cdd:PRK08760 432 --------------------SPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRF 464
|
|
| PRK05636 |
PRK05636 |
replicative DNA helicase; Provisional |
2-449 |
2.71e-88 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180177 [Multi-domain] Cd Length: 505 Bit Score: 278.26 E-value: 2.71e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 2 QQEHFDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAG---EPISISFLKKHKKIDEQI---- 74
Cdd:PRK05636 68 RQPPYDNEAEQGVLGAMLLSPDTVIDIVEVLTPEDFYRPAHQLIFQAIIDLFSDNkeiDPVIVAGRLDRTNDLERVggap 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 75 -LTEIIA-TPSIIDLPAYVNELREKSIKRQLLSFAhllpTRI-------NDNRAVSEISDEIGKEIFNITNRVNTNDIKD 145
Cdd:PRK05636 148 yLHTLIQsVPTAANARYYAEIVSEKAVLRRLVDAG----TRVvqlgyegDEGAEIDSVIDRAQQEVFAVSQKNQSEDYAV 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 146 IEIVLSELLEEFKkQKSLENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKV-LRQDKGVVMFSL 224
Cdd:PRK05636 224 LADILDPTMDELE-MLSSQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSAsIKHNKASVIFSL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 225 EMPAAQIMQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKaQEESIGLCVI 304
Cdd:PRK05636 303 EMSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLGKIAQAPIFIDDSANLTMMEIRSKARRLK-QKHDLKLIVV 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 305 DYIGLMMSNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRde 384
Cdd:PRK05636 382 DYLQLMSSGKRVESRQQEVSEFSRQLKLLAKELDVPLIAISQLNRGPESRTDKRPQLADLRESGSLEQDADMVMLLYR-- 459
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488868666 385 vyreQDEKERENKAKAEgkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVDKPR 449
Cdd:PRK05636 460 ----PDSQDKDDERAGE----------------ADIILAKHRGGPIDTVQVAHQLHYSRFVDMAR 504
|
|
| PRK09165 |
PRK09165 |
replicative DNA helicase; Provisional |
11-446 |
3.07e-84 |
|
replicative DNA helicase; Provisional
Pssm-ID: 181676 [Multi-domain] Cd Length: 497 Bit Score: 267.52 E-value: 3.07e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 11 ERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAG---EPISI-SFLKKHKKIDE----QILTEIIA-T 81
Cdd:PRK09165 28 EQALLGAILINNRALDRVSDFLKPEHFFEPLHQRIYEAIAKIIRKGklaTPVTLkTFLENDEALGElggvQYLAKLATeA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 82 PSIIDLPAYVNELREKSIKRQLLsfahllptrindnravseisdEIGKEIFNITNRVNTND-----IKDIEIVLSELLEE 156
Cdd:PRK09165 108 VTIINARDYGRIIYDLALRRELI---------------------NIGEDVVNNAYDAPVDVapqeqIEDAEQKLYELAET 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 157 ------FKK-QKSLE------------NKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNF---IEKVLR 214
Cdd:PRK09165 167 gryeggFQSfGTAITeavdmanaafkrDGHLSGISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIafnAAKAYR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 215 -----------QDKGVV-MFSLEMPAAQIMQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATI 282
Cdd:PRK09165 247 reaqpdgskkaVNGGVVgFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLVDASQELQKLPLYIDDTPALSI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 283 TDVRAILRRLKaQEESIGLCVIDYIGLMMS---NSNFNdRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRP 359
Cdd:PRK09165 327 SQLRARARRLK-RQHGLDLLVVDYLQLIRGsskRSSDN-RVQEISEITQGLKALAKELNIPVIALSQLSRQVEQRDDKRP 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 360 MMSDLRESGAIEQDADTILFVYRDEVY------REQDEKERENKAKAE---GKpyqrnfipnpmqenAEILVGKNRNGPV 430
Cdd:PRK09165 405 QLSDLRESGSIEQDADVVMFVYREEYYlkrkepREGTPKHEEWQEKMEkvhNK--------------AEVIIAKQRHGPT 470
|
490
....*....|....*.
gi 488868666 431 GVVEVLFLKEKSCFVD 446
Cdd:PRK09165 471 GTVKLAFESEFTRFGD 486
|
|
| PRK06321 |
PRK06321 |
replicative DNA helicase; Provisional |
14-451 |
3.06e-74 |
|
replicative DNA helicase; Provisional
Pssm-ID: 180528 [Multi-domain] Cd Length: 472 Bit Score: 240.90 E-value: 3.06e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 14 ILSSCIMSEDAYSSIAGD-IEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKHKKIDEQIltEIIATPS-IIDLP--- 88
Cdd:PRK06321 25 IVLGCMLTSVNYLNLAANqLQEDDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQL--NVIGGPSyLITLAefa 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 89 ---AYVNE----LREKSIKRQLLSFAHLLPTR-INDNRAVSEISDEIGKEIFNITNRVNTND---IKDI----------- 146
Cdd:PRK06321 103 gtsAYIEEyaeiIRSKSILRKMIQTAKEIEKKaLEEPKDVATALDEAQNLLFKISQTTNLAQyvlVADKlkgltsskdkp 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 147 -EIVLSELLEEFKKQKSLENKSVI-GLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDK-GVVMFS 223
Cdd:PRK06321 183 fLLQLQERQEAFQQSAQGDSSPMIsGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQNRlPVGIFS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 224 LEMPAAQIMQRMLSAKTSIPLQKILTADLNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKaQEESIGLCV 303
Cdd:PRK06321 263 LEMTVDQLIHRIICSRSEVESKKISVGDLSGRDFQRIVSVVNEMQEHTLLIDDQPGLKITDLRARARRMK-ESYDIQFLI 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 304 IDYIGLMM---SNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFV 380
Cdd:PRK06321 342 IDYLQLLSgsgNLRNSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRANHRPMMSDLRESGSIEQDSDLVMFL 421
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488868666 381 YRDEVYReqdekerenkakaegkpyqrnfiPNPMQENAEILVGKNRNGPVGVVEVLFLKEKSCFVDKPRFE 451
Cdd:PRK06321 422 LRREYYD-----------------------PNDKPGTAELIVAKNRHGSIGSVPLVFEKEFARFRNYAACE 469
|
|
| PRK06749 |
PRK06749 |
replicative DNA helicase; Provisional |
7-446 |
9.06e-68 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168658 [Multi-domain] Cd Length: 428 Bit Score: 222.52 E-value: 9.06e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 7 DLDLERAILSSCIMSEDAYSSIagDIEPKDFSLKAHQDVFKAIIACVNAGEPISI---------SFLKKHKKIDEQI-LT 76
Cdd:PRK06749 5 NVEAEKTVLGSLLLDGELIKEC--RLTEQYFSMPVHKSIFQLMRKMEDEGQPIDLvtftsrvdpNFLKGIGGMEYFIgLM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 77 EIIATPSiiDLPAYVNELREKSIKRQLLSFAHLLPTRINDNRAVSEISDEIgKEIFNI--TNRVNTNDIKDieiVLSELL 154
Cdd:PRK06749 83 DGVPTTS--NFSYYEGLVRGAWKMYQAGVLGHKMGERLIAEKSEKIIGETI-TALCELeeKDCVCEFDLKD---ALVDLY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 155 EEFKKqkslENKSVIGLDTGFEDLNTMTKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQR 234
Cdd:PRK06749 157 EELHQ----DAKEITGIETGYTSLNKMTCGLQEGDFVVLGARPSMGKTAFALNVGLHAAKSGAAVGLFSLEMSSKQLLKR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 235 MLSAKTSIPLQKILTAD--LNDNEWERIGDACNYYSKKKLFIYDSGYATITDVRAILRRLKAQE-ESIGLCVIDYIGLMM 311
Cdd:PRK06749 233 MASCVGEVSGGRLKNPKhrFAMEDWEKVSKAFAEIGELPLEIYDNAGVTVQDIWMQTRKLKRKHgDKKILIIVDYLQLIT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 312 SNSNFN-DRHLQVSEISRGLKLLARELDMPIIALSQLNRSLEQRANKRPMMSDLRESGAIEQDADTILFVYRDEVYreqd 390
Cdd:PRK06749 313 GDPKHKgNRFQEISEISRKLKLLARELNVCVVALSQLSRSVESRQDKRPLLSDLRETGQIEQDADVIMLMYREDYY---- 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 488868666 391 EKERENKakaegkpyqrnfipnpmqENAEILVGKNRNGPVGVVEVLFLKEKSCFVD 446
Cdd:PRK06749 389 DKETMQK------------------EMTEIHVAKHRNGPVGSFKLRFLKEFGRFVE 426
|
|
| DnaB |
pfam00772 |
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ... |
6-96 |
4.18e-16 |
|
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.
Pssm-ID: 395624 [Multi-domain] Cd Length: 103 Bit Score: 73.81 E-value: 4.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 6 FDLDLERAILSSCIMSEDAYSSIAGDIEPKDFSLKAHQDVFKAIIACVNAGEPISISFLKKH---KKIDEQI-----LTE 77
Cdd:pfam00772 4 HNIEAEQAVLGALLLDPEAIDEVADILKPEDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEElekKGKLEDVggiayLAE 83
|
90 100
....*....|....*....|
gi 488868666 78 II-ATPSIIDLPAYVNELRE 96
Cdd:pfam00772 84 LAaNVPSAANIEYYARIVKE 103
|
|
| RAD55 |
COG0467 |
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; |
171-385 |
1.72e-13 |
|
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
Pssm-ID: 440235 [Multi-domain] Cd Length: 221 Bit Score: 69.56 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 171 LDTGFEDLNTMTK-GFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLSakTSIPLQKilt 249
Cdd:COG0467 2 VPTGIPGLDELLGgGLPRGSSTLLSGPPGTGKTTLALQFLAEGLRRGEKGLYVSFEESPEQLLRRAES--LGLDLEE--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 250 adlndnewerigdacnYYSKKKLFIYD-SGYATITDVRAILRRLKAQEESIG--LCVIDYI-GLMMSNSNFNDRHLQVSE 325
Cdd:COG0467 77 ----------------YIESGLLRIIDlSPEELGLDLEELLARLREAVEEFGakRVVIDSLsGLLLALPDPERLREFLHR 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 326 ISRGLKllarELDMPIIALSQLnrsleqrankrPMMSDLRESGAIEQDADTILFVYRDEV 385
Cdd:COG0467 141 LLRYLK----KRGVTTLLTSET-----------GGLEDEATEGGLSYLADGVILLRYVEL 185
|
|
| RecA-like_Gp4D_helicase |
cd19483 |
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ... |
191-395 |
1.72e-12 |
|
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410891 [Multi-domain] Cd Length: 231 Bit Score: 66.82 E-value: 1.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 191 IIIAARPGMGKTTLC----LNFIEKvlrQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKILTADLNDNEWERIGDAcNY 266
Cdd:cd19483 1 VTIGAGSGIGKSTIVrelaYHLITE---HGEKVGIISLEESVEETAKGLAGKHLGKPEPLELPRDDITEEEEDDAFD-NE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 267 YSKKKLFIYDS-GYATITDVRAILRRLKAQEEsIGLCVIDYIGLMMSNSNFNDRHLQVSEISRGLKLLARELDMPIIALS 345
Cdd:cd19483 77 LGSGRFFLYDHfGSLDWDNLKEKIRYMVKVLG-CKVIVLDHLTILVSGLDSSDERKELDEIMTELAALVKELGVTIILVS 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 488868666 346 QLNRSLEQRA---NKRPMMSDLRESGAIEQDADTILFVYRDevyrEQDEKERE 395
Cdd:cd19483 156 HLRRPGGGKGheeGGEVSESDLRGSSAIAQLSDYVIGLERN----KQADDPVE 204
|
|
| PRK05973 |
PRK05973 |
replicative DNA helicase; Provisional |
185-365 |
2.57e-12 |
|
replicative DNA helicase; Provisional
Pssm-ID: 168322 [Multi-domain] Cd Length: 237 Bit Score: 66.21 E-value: 2.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 185 FKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMlsakTSIPLQKILTADlndnewerigdac 264
Cdd:PRK05973 61 LKPGDLVLLGARPGHGKTLLGLELAVEAMKSGRTGVFFTLEYTEQDVRDRL----RALGADRAQFAD------------- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 265 nyyskkkLFIYDSGYATITDVraILRRLKAQEESiGLCVIDYIGLMMSNSNFNDRHLQVseisRGLKLLARELDMPIIAL 344
Cdd:PRK05973 124 -------LFEFDTSDAICADY--IIARLASAPRG-TLVVIDYLQLLDQRREKPDLSVQV----RALKSFARERGLIIVFI 189
|
170 180
....*....|....*....|.
gi 488868666 345 SQLNRSLEQRANKRPMMSDLR 365
Cdd:PRK05973 190 SQIDRSFDPSAKPLPDIRDVR 210
|
|
| PRK07773 |
PRK07773 |
replicative DNA helicase; Validated |
369-449 |
7.56e-10 |
|
replicative DNA helicase; Validated
Pssm-ID: 236093 [Multi-domain] Cd Length: 886 Bit Score: 61.30 E-value: 7.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 369 AIEQDADTILFVYRDEVYREQDEKEREnkakaegkpyqrnfipnpmqenAEILVGKNRNGPVGVVEVLFLKEKSCFVDKP 448
Cdd:PRK07773 827 SIEQDADVVILLYRPDYYDRDDPRGGE----------------------AEFIVAKHRNGPTGTVTLAFQLHLSRFANLA 884
|
.
gi 488868666 449 R 449
Cdd:PRK07773 885 R 885
|
|
| 41 |
PHA02542 |
41 helicase; Provisional |
178-384 |
1.14e-09 |
|
41 helicase; Provisional
Pssm-ID: 222864 [Multi-domain] Cd Length: 473 Bit Score: 60.08 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 178 LNTMTKG-FKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLSAKTSIPLQKIltADLNDNE 256
Cdd:PHA02542 179 LNKITKGgAERKTLNVLLAGVNVGKSLGLCSLAADYLQQGYNVLYISMEMAEEVIAKRIDANLLDVSLDDI--DDLSKAE 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 257 WERIGDACNYYSKKKLFI--YDSGYATITDVRAILRRLKaQEESIGLCVI--DYIGLMMS--------NSNfndrhLQVS 324
Cdd:PHA02542 257 YKAKMEKLRSKTQGKLIIkqYPTGGAHAGHFRALLNELK-LKKNFKPDVIivDYLGICASsrlrvsseNSY-----TYVK 330
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 325 EISRGLKLLARELDMPIIALSQLNRSleQRANKRPMMSDLRESGAIEQDADTILFVYRDE 384
Cdd:PHA02542 331 AIAEELRGLAVEHDVVVWTAAQTTRS--GWDSSDVDMSDTAESAGLPATADFMLAVIETE 388
|
|
| AAA_25 |
pfam13481 |
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins. |
188-348 |
1.59e-08 |
|
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
Pssm-ID: 463892 [Multi-domain] Cd Length: 193 Bit Score: 54.31 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 188 GELIIIAARPGMGKTTLCLN------------FIEKVLRQDKgVVMFSLEMPAAQIMQRMLSAKTsiplqkiltaDLNDN 255
Cdd:pfam13481 33 GGLGLLAGAPGTGKTTLALDlaaavatgkpwlGGPRVPEQGK-VLYVSAEGPADELRRRLRAAGA----------DLDLP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 256 EWERIGDAcnyYSKKKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMMSNSNFNDRhlQVSEISRGLKLLAR 335
Cdd:pfam13481 102 ARLLFLSL---VESLPLFFLDRGGPLLDADVDALEAALEEVEDPDLVVIDPLARALGGDENSNS--DVGRLVKALDRLAR 176
|
170
....*....|...
gi 488868666 336 ELDMPIIALSQLN 348
Cdd:pfam13481 177 RTGATVLLVHHVG 189
|
|
| KaiC-like |
cd01124 |
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ... |
173-238 |
7.02e-06 |
|
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410869 [Multi-domain] Cd Length: 222 Bit Score: 46.87 E-value: 7.02e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488868666 173 TGFEDLNTMTK-GFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLSA 238
Cdd:cd01124 3 TGIPGLDELLGgGIPKGSVTLLTGGPGTGKTLFGLQFLYAGAKNGEPGLFFTFEESPERLLRNAKSF 69
|
|
| RecA-like |
cd01393 |
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ... |
188-382 |
1.90e-05 |
|
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Pssm-ID: 410881 [Multi-domain] Cd Length: 185 Bit Score: 45.04 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 188 GELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEmpAAQIMQRmlsaktsipLQKILTADLNDNewERIGDACNyy 267
Cdd:cd01393 1 GKITEIYGPPGSGKTQLALQLAANALLLGGGVVWIDTE--GAFPPSR---------LVQILEASPSSE--LELAEALS-- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 268 skkKLFiydsgYATITDVRAILRRLKAQEES------IGLCVID---------YIGLMMSNSNFNDRHLQVSEISRGLKL 332
Cdd:cd01393 66 ---RLL-----YFRPPDTLAHLLALDSLPESlfpppnTSLVVVDsvsalfrkaFPRGGDGDSSSSLRARLLSQLARALQK 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 488868666 333 LARELDMPIIALSQLnrsleqRANKRPMMSDLRESGAI----EQDADTILFVYR 382
Cdd:cd01393 138 LAAQFNLAVVVTNQV------TTKIRGGSGASLVPPALgntwEHSVSTRLLLYR 185
|
|
| PRK09302 |
PRK09302 |
circadian clock protein KaiC; Reviewed |
173-237 |
9.10e-05 |
|
circadian clock protein KaiC; Reviewed
Pssm-ID: 236461 [Multi-domain] Cd Length: 509 Bit Score: 44.87 E-value: 9.10e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488868666 173 TGFEDLNTMT-KGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLS 237
Cdd:PRK09302 257 SGVPDLDEMLgGGFFRGSIILVSGATGTGKTLLASKFAEAACRRGERCLLFAFEESRAQLIRNARS 322
|
|
| Rad51B |
cd19493 |
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
193-346 |
9.32e-05 |
|
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410901 [Multi-domain] Cd Length: 222 Bit Score: 43.46 E-value: 9.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 193 IAARPGMGKTTLCLNFIEKVLRQ------DKGVVMFSLE----MPAAQIMQRMlsaktSIPLQKILTADLNDNEWERIgd 262
Cdd:cd19493 16 ITGASGSGKTQFALTLASSAAMParkgglDGGVLYIDTEskfsAERLAEIAEA-----RFPEAFSGFMEENERAEEML-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 263 acnyyskKKLFIYdsgyaTITDVRAILRRLKAQEESI-----GLCVIDYIGLMMSNS------NFNDRHLQVSEISRGLK 331
Cdd:cd19493 89 -------KRVAVV-----RVTTLAQLLERLPNLEEHIlssgvRLVVIDSIAALVRREfggsdgEVTERHNALAREASSLK 156
|
170
....*....|....*
gi 488868666 332 LLARELDMPIIALSQ 346
Cdd:cd19493 157 RLAEEFRIAVLVTNQ 171
|
|
| KaiC_C |
cd19484 |
C-terminal domain of Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most ... |
173-237 |
3.52e-04 |
|
C-terminal domain of Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410892 [Multi-domain] Cd Length: 218 Bit Score: 41.93 E-value: 3.52e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488868666 173 TGFEDLNTM--TKGFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLS 237
Cdd:cd19484 3 TGIPRLDAMlgGGGFFRGSSILVSGATGTGKTLLAASFADAACRRGERCLYFAFEESPAQLIRNAKS 69
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
188-355 |
1.44e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.89 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 188 GELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMFSLEMPAAQIMQRMLsaktsiplqkiltadlndnewerigdacnyy 267
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLL------------------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 268 skkKLFIYDSGYATITDVRAILRRLKAQEESIGLCVIDYIGLMmsNSNFNDRHLQVSEISRGLKLLARELDMPIIALSQL 347
Cdd:smart00382 51 ---LIIVGGKKASGSGELRLRLALALARKLKPDVLILDEITSL--LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTND 125
|
....*...
gi 488868666 348 NRSLEQRA 355
Cdd:smart00382 126 EKDLGPAL 133
|
|
| Rad51D |
cd19489 |
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ... |
184-342 |
7.46e-03 |
|
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Pssm-ID: 410897 [Multi-domain] Cd Length: 209 Bit Score: 37.62 E-value: 7.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 184 GFKGGELIIIAARPGMGKTTLCLNFIEKVLRQDKGVVMF-----SLempAAQIMQRMLSAKTSIpLQKILTADlndnewE 258
Cdd:cd19489 3 GLRTGEITELVGESSSGKTQLCLTAAANVASRSGQNVLYidtksSF---SARRLAQILKSRAQD-AEEIDKAL------Q 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 259 RIgdacnyyskKKLFIYDSgYATITDVRAILRRLKAQEESIG----LCVIDYIGLMMSNSNFNDRHLQ----VSEISRGL 330
Cdd:cd19489 73 RI---------RVVRVFDP-YELLDLLEELRNTLSQQQENLYsrlkLVIIDSLSALISPLLGGSKHSEghalLASLARLL 142
|
170
....*....|..
gi 488868666 331 KLLARELDMPII 342
Cdd:cd19489 143 KKLAAEYQIAVL 154
|
|
| KaiC-N |
cd19485 |
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most ... |
171-304 |
9.44e-03 |
|
N-terminal domain of Circadian Clock Protein Kaic; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.
Pssm-ID: 410893 [Multi-domain] Cd Length: 226 Bit Score: 37.73 E-value: 9.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 171 LDTGFEDLNTMTKG-FKGGELIIIAARPGMGKTTLCLNFI-EKVLRQDKGVVMFSLEMPAAQIMQRMLSAK--------- 239
Cdd:cd19485 1 LPTGIEGFDDITHGgLPKGRPTLICGTAGTGKTLFAAQFLvNGIKEFGEPGVFVTFEESPEDIIKNMASFGwdlpklvae 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488868666 240 --------TSIPLQKILTADLNDNE-WERIGDACNYYSKKKLFIyDS------GYATITDVRAILRRLKAQEESIGLCVI 304
Cdd:cd19485 81 gkllildaSPEPSEEEVTGEYDLEAlLIRIEYAIRKIGAKRVSL-DSleavfsGLSDSAVVRAELLRLFAWLKQKGVTAI 159
|
|
| |
