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Conserved domains on  [gi|488941482|ref|WP_002852557|]
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MULTISPECIES: WD40 repeat domain-containing protein [Campylobacter]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
153-295 3.56e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941482 153 SSLNDAVLNEDKSRLIAGFESGEVELFDLKNWKMLKNYdKMHKDNIYQVDF--KNNVILSCGTDRRIGVVKNEEQNFLQK 230
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488941482 231 ----DFLIYTCALSPSGEFAVYSDNEAGVsEVFSTSDFKPVKTFNNENLMSEFIIFLNNKDFIVSGFGD 295
Cdd:COG2319  200 ltghTGAVRSVAFSPDGKLLASGSADGTV-RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
153-295 3.56e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941482 153 SSLNDAVLNEDKSRLIAGFESGEVELFDLKNWKMLKNYdKMHKDNIYQVDF--KNNVILSCGTDRRIGVVKNEEQNFLQK 230
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488941482 231 ----DFLIYTCALSPSGEFAVYSDNEAGVsEVFSTSDFKPVKTFNNENLMSEFIIFLNNKDFIVSGFGD 295
Cdd:COG2319  200 ltghTGAVRSVAFSPDGKLLASGSADGTV-RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
153-295 3.56e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941482 153 SSLNDAVLNEDKSRLIAGFESGEVELFDLKNWKMLKNYdKMHKDNIYQVDF--KNNVILSCGTDRRIGVVKNEEQNFLQK 230
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488941482 231 ----DFLIYTCALSPSGEFAVYSDNEAGVsEVFSTSDFKPVKTFNNENLMSEFIIFLNNKDFIVSGFGD 295
Cdd:COG2319  200 ltghTGAVRSVAFSPDGKLLASGSADGTV-RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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