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Conserved domains on  [gi|488941569|ref|WP_002852644|]
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MULTISPECIES: molybdopterin-guanine dinucleotide biosynthesis protein B [Campylobacter]

Protein Classification

molybdopterin-guanine dinucleotide biosynthesis protein MobB( domain architecture ID 10015522)

molybdopterin-guanine dinucleotide biosynthesis protein MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mobB TIGR00176
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ...
 5-155 1.18e-64

molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


:

Pssm-ID: 272943 [Multi-domain]  Cd Length: 155  Bit Score: 194.90  E-value: 1.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDpADKAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSH---ENRD 81
Cdd:TIGR00176   1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHD-HHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHetqEERD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   82 ILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN--AIASYEKISHPYLTWLDLNDIQAICQYILKN 155
Cdd:TIGR00176  80 LEALLDRLPDLDIILVEGFKDSPLPKIVVFRNPAEESEIIRPKiiAIASDESLSALKLPVLDLNDVEAIAAFIEKN 155
 
Name Accession Description Interval E-value
mobB TIGR00176
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ...
 5-155 1.18e-64

molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 272943 [Multi-domain]  Cd Length: 155  Bit Score: 194.90  E-value: 1.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDpADKAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSH---ENRD 81
Cdd:TIGR00176   1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHD-HHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHetqEERD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   82 ILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN--AIASYEKISHPYLTWLDLNDIQAICQYILKN 155
Cdd:TIGR00176  80 LEALLDRLPDLDIILVEGFKDSPLPKIVVFRNPAEESEIIRPKiiAIASDESLSALKLPVLDLNDVEAIAAFIEKN 155
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 1-157 2.74e-44

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 143.40  E-value: 2.74e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   1 MKqlIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADkAQFDFNGKDSFKFFQSGA-EVMVLSPTRTTFFSH-- 77
Cdd:COG1763    1 MP--VLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHD-FDIDTPGKDSYRHREAGAdEVLVASPERWALMTElp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569  78 ENRDILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN----AIASYEKISHPyLTWLDLNDIQAICQYIL 153
Cdd:COG1763   78 EEPSLDELLARLDDVDLVLVEGFKHEPLPKIEVHRAEEGKPLLYPEDpniiAVASDAPLPTG-LPVFDLNDPEAIADFIL 156


                 ....
gi 488941569 154 KNAK 157
Cdd:COG1763  157 EWLK 160
MobB cd03116
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ...
 4-153 2.30e-38

molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.


Pssm-ID: 349770 [Multi-domain]  Cd Length: 157  Bit Score: 128.14  E-value: 2.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   4 LIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADKaQFDFNGKDSFKFFQSGA-EVMVLSPTRTTFFS---HEN 79
Cdd:cd03116    1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGF-DIDTPGKDSYRHRQAGAdAVLVSSPNRLALIHerpEWE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488941569  80 RDILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDE--SYFIFSN--AIASYEKISHPYLTWLDLNDIQAICQYIL 153
Cdd:cd03116   80 LTLLELLARFSDVDLVLVEGFKKEPIPKIEVFREEEGKplLLPEDPNviAVATDEPLDMLGLPVFDLNDVEEIADFIL 157
MobB pfam03205
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
 5-128 4.13e-23

Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.


Pssm-ID: 427196 [Multi-domain]  Cd Length: 133  Bit Score: 88.37  E-value: 4.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADkaqFDFN--GKDSFKFFQSGA-EVMVLSPTRTTFFsHENRD 81
Cdd:pfam03205   1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHG---FDIDkpGKDSWRHRKAGAsEVLVASPGRWALM-HELRD 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   82 I----LKAL-KLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN----AIAS 128
Cdd:pfam03205  77 EpepsLEELlARLSPVDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDpdiiAVAS 132
PRK14494 PRK14494
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ...
 1-108 2.41e-19

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional


Pssm-ID: 237731 [Multi-domain]  Cd Length: 229  Bit Score: 81.18  E-value: 2.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   1 MKqlIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHdpaDKAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSHENR 80
Cdd:PRK14494   1 MR--AIGVIGFKDSGKTTLIEKILKNLKERGYRVATAKH---THHEFDKPDTDTYRFKKAGAEVVVVSTDETAAFLYDRM 75

                         90       100
                 ....*....|....*....|....*....
gi 488941569  81 DiLKALKLSPDFDICLVEGLKT-LDLPRI 108
Cdd:PRK14494  76 D-LNEILSLLDADFLLIEGFKElLNIPKI 103
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 5-37 1.09e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.35  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 488941569     5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLII 37
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYI 36
 
Name Accession Description Interval E-value
mobB TIGR00176
molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor ...
 5-155 1.18e-64

molybdopterin-guanine dinucleotide biosynthesis protein MobB; This molybdenum cofactor biosynthesis enzyme is similar to the urease accessory protein UreG and to the hydrogenase accessory protein HypB, both GTP hydrolases involved in loading nickel into the metallocenters of their respective target enzymes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 272943 [Multi-domain]  Cd Length: 155  Bit Score: 194.90  E-value: 1.18e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDpADKAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSH---ENRD 81
Cdd:TIGR00176   1 VLQIVGPKNSGKTTLIERLVKALKARGYRVATIKHD-HHDFDIDKNGKDSYRHREAGADQVIVASSRRYAFMHetqEERD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   82 ILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN--AIASYEKISHPYLTWLDLNDIQAICQYILKN 155
Cdd:TIGR00176  80 LEALLDRLPDLDIILVEGFKDSPLPKIVVFRNPAEESEIIRPKiiAIASDESLSALKLPVLDLNDVEAIAAFIEKN 155
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 1-157 2.74e-44

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 143.40  E-value: 2.74e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   1 MKqlIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADkAQFDFNGKDSFKFFQSGA-EVMVLSPTRTTFFSH-- 77
Cdd:COG1763    1 MP--VLGIVGYSGSGKTTLLEKLIPELKARGLRVGTIKHAHHD-FDIDTPGKDSYRHREAGAdEVLVASPERWALMTElp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569  78 ENRDILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN----AIASYEKISHPyLTWLDLNDIQAICQYIL 153
Cdd:COG1763   78 EEPSLDELLARLDDVDLVLVEGFKHEPLPKIEVHRAEEGKPLLYPEDpniiAVASDAPLPTG-LPVFDLNDPEAIADFIL 156


                 ....
gi 488941569 154 KNAK 157
Cdd:COG1763  157 EWLK 160
MobB cd03116
molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace ...
 4-153 2.30e-38

molybdopterin-guanine dinucleotide biosynthesis protein B; Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In Escherichia coli, the synthesis of Moco involves genes from several loci: moa, mob, mod, moe and mog. The mob locus contains mobA and mobB genes. MobB catalyzes the attachment of the guanine dinucleotide to molybdopterin.


Pssm-ID: 349770 [Multi-domain]  Cd Length: 157  Bit Score: 128.14  E-value: 2.30e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   4 LIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADKaQFDFNGKDSFKFFQSGA-EVMVLSPTRTTFFS---HEN 79
Cdd:cd03116    1 KIVGVVGKSGSGKTTLIEKLIPELKARGLRVAVIKHTHHGF-DIDTPGKDSYRHRQAGAdAVLVSSPNRLALIHerpEWE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488941569  80 RDILKALKLSPDFDICLVEGLKTLDLPRISVFCKEIDE--SYFIFSN--AIASYEKISHPYLTWLDLNDIQAICQYIL 153
Cdd:cd03116   80 LTLLELLARFSDVDLVLVEGFKKEPIPKIEVFREEEGKplLLPEDPNviAVATDEPLDMLGLPVFDLNDVEEIADFIL 157
MobB pfam03205
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
 5-128 4.13e-23

Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.


Pssm-ID: 427196 [Multi-domain]  Cd Length: 133  Bit Score: 88.37  E-value: 4.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADkaqFDFN--GKDSFKFFQSGA-EVMVLSPTRTTFFsHENRD 81
Cdd:pfam03205   1 ILGIVGWSGSGKTTLLEKLIPELKARGLRVGTIKHAHHG---FDIDkpGKDSWRHRKAGAsEVLVASPGRWALM-HELRD 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   82 I----LKAL-KLSPDFDICLVEGLKTLDLPRISVFCKEIDESYFIFSN----AIAS 128
Cdd:pfam03205  77 EpepsLEELlARLSPVDLVLVEGFKKEPYPKIEVHRAALGKPPLLPCDpdiiAVAS 132
PRK14494 PRK14494
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing ...
 1-108 2.41e-19

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional


Pssm-ID: 237731 [Multi-domain]  Cd Length: 229  Bit Score: 81.18  E-value: 2.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   1 MKqlIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHdpaDKAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSHENR 80
Cdd:PRK14494   1 MR--AIGVIGFKDSGKTTLIEKILKNLKERGYRVATAKH---THHEFDKPDTDTYRFKKAGAEVVVVSTDETAAFLYDRM 75

                         90       100
                 ....*....|....*....|....*....
gi 488941569  81 DiLKALKLSPDFDICLVEGLKT-LDLPRI 108
Cdd:PRK14494  76 D-LNEILSLLDADFLLIEGFKElLNIPKI 103
PRK14489 PRK14489
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; ...
 6-152 4.85e-18

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional


Pssm-ID: 237727 [Multi-domain]  Cd Length: 366  Bit Score: 79.41  E-value: 4.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   6 IAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPaDKAQFDFNGKDSFKFFQSGAEV-MVLSPTRTTFFSHENR---- 80
Cdd:PRK14489 208 LGVVGYSGTGKTTLLEKLIPELIARGYRIGLIKHSH-HRVDIDKPGKDSHRLRAAGANPtMIVCPERWALMRETPEeavp 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569  81 -DILKALKLSPDFDICLVEGLKTLDLPRISVFCKEID---ESYFIFSNAIASYEKISHPYLtwLDLNDIQAICQYI 152
Cdd:PRK14489 287 fKVLIATFDPEEVDLILVEGFKHEPLPKIQLHRQLISkplPELDLWTIATATDYPLARDPR--LDINDVKQIADFV 360
PRK14490 PRK14490
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; ...
 6-108 6.15e-16

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional


Pssm-ID: 237728 [Multi-domain]  Cd Length: 369  Bit Score: 73.54  E-value: 6.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   6 IAFSGPSNSGKTTLITKIADNfLQQNLKVLIIKHDpADKAQFDFNGKDSFKFFQSGAE-VMVLSPTRTTFFSHENRDILK 84
Cdd:PRK14490   8 IAFCGYSGSGKTTLITALVRR-LSERFSVGYYKHG-CHRFDIDREGKDSDLARKAGAStVMISDPEKHALIAGGPPDPLL 85

                         90       100
                 ....*....|....*....|....
gi 488941569  85 ALKLSPDFDICLVEGLKTLDLPRI 108
Cdd:PRK14490  86 ERGAFLDCDLLLVEGLKELPLPKI 109
PRK14491 PRK14491
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ...
 5-160 7.17e-16

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional


Pssm-ID: 237729 [Multi-domain]  Cd Length: 597  Bit Score: 73.88  E-value: 7.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHdpadkAQFDFN----GKDSFKFFQSGAEVMVLSPTRTTFFSHENR 80
Cdd:PRK14491  12 LLGFCAYSGTGKTTLLEQLIPELNQRGLRLAVIKH-----AHHNFDvdqpGKDSYRLRKAGASQMLVASRVRWALMTETP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569  81 D--------ILKALKLSPdFDICLVEGLKTLDLPRISVFCKEIDESyFIFSN-----AIASYEKISHPYLTWLDLNDIQA 147
Cdd:PRK14491  87 RdgepelphLLKQIDADK-VDIVLVEGFKKLALPKIELHRAAHGKP-WIYPHdeniiAIACDDTPLPSELPRLDINDVAA 164

                        170
                 ....*....|...
gi 488941569 148 ICQYILKNAKNLQ 160
Cdd:PRK14491 165 IADFVLEYAQNWQ 177
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 1-108 8.05e-12

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 61.55  E-value: 8.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   1 MKqlIIAFSGPSNSGKTTLITKIADNfLQQNLKVLIIKHDpaDKAQFDFNGKDSFKFFQSGAEVMV-LSPTRTTFFShEN 79
Cdd:PRK14493   1 MK--VLSIVGYKATGKTTLVERLVDR-LSGRGRVGTVKHM--DTERLNPDGTDTGRHFDAGADVVYgLTDGEWVASG-RD 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 488941569  80 RDILKALK-LSPDFDICLVEGLKTLDLPRI 108
Cdd:PRK14493  75 RSLDDALDdLAPGMDYAVVEGFKDSRLPKV 104
PRK10751 PRK10751
molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional
 5-153 3.58e-10

molybdopterin-guanine dinucleotide biosynthesis protein B; Provisional


Pssm-ID: 236750 [Multi-domain]  Cd Length: 173  Bit Score: 55.47  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   5 IIAFSGpsnSGKTTLITKIADNFLQQNLKVLIIKHDPADkAQFDFNGKDSFKFFQSGAE-VMVLSPTR----TTFFSHEN 79
Cdd:PRK10751  11 IAAWSG---TGKTTLLKKLIPALCARGIRPGLIKHTHHD-MDVDKPGKDSYELRKAGAAqTLVASQQRwalmTETPDQEE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569  80 RDI------LKALKLspdfDICLVEGLKTLDLPRISVFCKE---------IDEsYFIfsnAIASYEKISHPyLTWLDLND 144
Cdd:PRK10751  87 LDLhylasrMDASKL----DLILVEGFKHEPIAKIALFRDGaghrpeelvIDE-HVI---AVASDVPLNLD-VPLLDIND 157


                 ....*....
gi 488941569 145 IQAICQYIL 153
Cdd:PRK10751 158 VEQIADFIV 166
PRK14495 PRK14495
putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion ...
 10-156 3.15e-09

putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional


Pssm-ID: 172967  Cd Length: 452  Bit Score: 54.68  E-value: 3.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569  10 GPSNSGKTTLITKIADNFLQQNLKVLIIKHDPADkAQFDFNGKDSFKFFQSGAEVMVLSPTRTTFFSHENRDILKAL--- 86
Cdd:PRK14495   8 GWKDAGKTGLVERLVAAIAARGFSVSTVKHSHHD-VDPDPPGSDSHRHRAAGAAEVVLAGPRRLILTREHRGEPPRLaai 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569  87 --KLSPdFDICLVEGLKTLDLPRISVFCKEIDESYF----IFSNAIASYEKISHPyLTWLDLNDIQAICQYILKNA 156
Cdd:PRK14495  87 leRMAP-VDLVLVEGYKTEPHPKIEVFRKAAGHALRqpedPWVRAVASDTQMALP-VPVLDLDDTEAVADFLLTDS 160
SRP54 pfam00448
SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 ...
 5-37 6.71e-05

SRP54-type protein, GTPase domain; This family includes relatives of the G-domain of the SRP54 family of proteins.


Pssm-ID: 459814 [Multi-domain]  Cd Length: 193  Bit Score: 41.37  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLII 37
Cdd:pfam00448   2 VILLVGLQGSGKTTTIAKLAAYLKKKGKKVLLV 34
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 4-100 2.59e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.82  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488941569   4 LIIAFSGPSNSGKTTLITKIADNFlqQNLKVLIIKHD----PADKAQFDFNGK---DSFKFFQSGAEVMVLSP------T 70
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARRLAEQL--GADKVVVISLDdyykDREHLPLDERGKpnfDHPEAFDLDLLNEHLEPlkagesV 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 488941569  71 RTTFFSHEN-RDILKALKLSPDfDICLVEGL 100
Cdd:COG0572   86 ELPVYDFATgTRSGETVKVEPA-DVIIVEGI 115
FlhF COG1419
Flagellar biosynthesis GTPase FlhF [Cell motility];
5-37 3.19e-04

Flagellar biosynthesis GTPase FlhF [Cell motility];


Pssm-ID: 441029 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 3.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNF-LQQNLKVLII 37
Cdd:COG1419  166 VIALVGPTGVGKTTTIAKLAARFvLRGKKKVALI 199
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 5-68 5.78e-04

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 37.41  E-value: 5.78e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488941569   5 IIAFSGP-SNSGKTTLITKIADNFLQQNLKVLIIKHDpaDKAQFD-FNGKDSFKFFQSGAEVMVLS 68
Cdd:cd01983    2 VIAVTGGkGGVGKTTLAAALAVALAAKGYKVLLIDLD--DYVLIDgGGGLETGLLLGTIVALLALK 65
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 5-37 1.09e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.35  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 488941569     5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLII 37
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYI 36
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 5-57 1.18e-03

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 37.53  E-value: 1.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNFlqQNLKVLIIKHD----------PADKAQFDFNGKDSFKF 57
Cdd:cd02023    1 IIGIAGGSGSGKTTVAEEIIEQL--GNPKVVIISQDsyykdlsheeLEERKNNNYDHPDAFDF 61
Tmk COG0125
Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the ...
 1-38 1.56e-03

Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 439895 [Multi-domain]  Cd Length: 206  Bit Score: 37.44  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 488941569   1 MKQLIIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIK 38
Cdd:COG0125    1 MKGKFIVFEGIDGSGKSTQIKLLAEYLEARGYDVVLTR 38
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-40 3.08e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 36.68  E-value: 3.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 488941569   1 MKQLIIAFSGPSNSGKTTLITKIADNFlqQNLKVLIIKHD 40
Cdd:PRK05480   4 KKPIIIGIAGGSGSGKTTVASTIYEEL--GDESIAVIPQD 41
Grc3 COG1341
Polynucleotide 5'-kinase, involved in rRNA processing [Translation, ribosomal structure and ...
 5-41 4.01e-03

Polynucleotide 5'-kinase, involved in rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440952  Cd Length: 353  Bit Score: 36.54  E-value: 4.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDP 41
Cdd:COG1341   37 RIMVLGPVDSGKSTLTTLLANKLLAEGLKVAIIDADV 73
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 5-41 4.68e-03

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 36.17  E-value: 4.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 488941569    5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDP 41
Cdd:pfam01656   1 IAIAGTKGGVGKTTLAANLARALARRGLRVLLIDLDP 37
FtsY cd17874
signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle ...
 5-36 4.82e-03

signal recognition particle receptor FtsY; FtsY, the bacterial signal-recognition particle (SRP) receptor (SR), is homologous to the SRP receptor alpha-subunit (SRalpha) of the eukaryotic SR. It interacts with the signal-recognition particle (SRP) and is required for the co-translational membrane targeting of proteins.


Pssm-ID: 349783  Cd Length: 199  Bit Score: 36.01  E-value: 4.82e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLI 36
Cdd:cd17874    2 VILFVGVNGVGKTTTIGKLAHYLKNQGKKVVL 33
PRK13768 PRK13768
GTPase; Provisional
 5-42 5.97e-03

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 36.00  E-value: 5.97e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 488941569   5 IIAFSGPSNSGKTTLITKIADNFLQQNLKVLIIKHDPA 42
Cdd:PRK13768   4 IVFFLGTAGSGKTTLTKALSDWLEEQGYDVAIVNLDPA 41
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 4-35 7.79e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 35.32  E-value: 7.79e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 488941569   4 LIIAFSGPSNSGKTTLITKIADNFLQQNLKVL 35
Cdd:cd01672    1 MFIVFEGIDGAGKTTLIELLAERLEARGYEVV 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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