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Conserved domains on  [gi|488945094|ref|WP_002856169|]
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MULTISPECIES: TlpA disulfide reductase family protein [Campylobacter]

Protein Classification

TlpA disulfide reductase family protein( domain architecture ID 10121831)

TlpA disulfide reductase family protein such as Bradyrhizobium japonicum thiol:disulfide interchange protein TlpA, an unusual thioredoxin which has been implicated in the biogenesis of cytochrome aa3 and also characterized as a reductant for the copper metallochaperone ScoI

CATH:  3.40.30.10
Gene Ontology:  GO:0015036
PubMed:  9099998|10049365|15558583
SCOP:  3000031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 66-126 1.17e-10

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


:

Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 56.48  E-value: 1.17e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSK-FIIIGLtHFEDVSDETVKKFADDYGAYY 126
Cdd:cd02966   19 GKVVLVNFWASWCPPCRAEMPELEALAKEYKDDgVEVVGV-NVDDDDPAAVKAFLKKYGITF 79
 
Name Accession Description Interval E-value
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 66-126 1.17e-10

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 56.48  E-value: 1.17e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSK-FIIIGLtHFEDVSDETVKKFADDYGAYY 126
Cdd:cd02966   19 GKVVLVNFWASWCPPCRAEMPELEALAKEYKDDgVEVVGV-NVDDDDPAAVKAFLKKYGITF 79
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 66-153 3.83e-07

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 47.38  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNsSKFIIIGLtHFEDvSDETVKKFADDYG---------------------- 123
Cdd:COG0526   28 GKPVLVNFWATWCPPCRAEMPVLKELAEEY-GGVVFVGV-DVDE-NPEAVKAFLKELGlpypvlldpdgelakaygvrgi 104

                         90       100       110
                 ....*....|....*....|....*....|.
gi 488945094 124 -AYYFLSNGGsndRIIAQILKDIDYQNMEQL 153
Cdd:COG0526  105 pTTVLIDKDG---KIVARHVGPLSPEELEEA 132
AhpC-TSA pfam00578
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) ...
 65-123 7.68e-04

AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 425763 [Multi-domain]  Cd Length: 124  Bit Score: 37.97  E-value: 7.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488945094   65 EGKVLMFDFFGT-FCTPCKEEALDLSKLWKNNSSK-FIIIGLTHfeDvSDETVKKFADDYG 123
Cdd:pfam00578  24 RGKWVVLFFYPAdWTPVCTTELPALADLYEEFKKLgVEVLGVSV--D-SPESHKAFAEKYG 81
PRK03147 PRK03147
thiol-disulfide oxidoreductase ResA;
65-123 2.84e-03

thiol-disulfide oxidoreductase ResA;


Pssm-ID: 179545 [Multi-domain]  Cd Length: 173  Bit Score: 36.90  E-value: 2.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488945094  65 EGKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSKFI-IIGLTHFEdvSDETVKKFADDYG 123
Cdd:PRK03147  60 KGKGVFLNFWGTWCKPCEKEMPYMNELYPKYKEKGVeIIAVNVDE--TELAVKNFVNRYG 117
 
Name Accession Description Interval E-value
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 66-126 1.17e-10

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 56.48  E-value: 1.17e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSK-FIIIGLtHFEDVSDETVKKFADDYGAYY 126
Cdd:cd02966   19 GKVVLVNFWASWCPPCRAEMPELEALAKEYKDDgVEVVGV-NVDDDDPAAVKAFLKKYGITF 79
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 66-153 3.83e-07

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 47.38  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNsSKFIIIGLtHFEDvSDETVKKFADDYG---------------------- 123
Cdd:COG0526   28 GKPVLVNFWATWCPPCRAEMPVLKELAEEY-GGVVFVGV-DVDE-NPEAVKAFLKELGlpypvlldpdgelakaygvrgi 104

                         90       100       110
                 ....*....|....*....|....*....|.
gi 488945094 124 -AYYFLSNGGsndRIIAQILKDIDYQNMEQL 153
Cdd:COG0526  105 pTTVLIDKDG---KIVARHVGPLSPEELEEA 132
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
66-123 1.33e-06

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 46.01  E-value: 1.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488945094  66 GKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSK-FIIIGLTHfeDvSDETVKKFADDYG 123
Cdd:COG1225   21 GKPVVLYFYATWCPGCTAELPELRDLYEEFKDKgVEVLGVSS--D-SDEAHKKFAEKYG 76
AhpC-TSA pfam00578
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) ...
 65-123 7.68e-04

AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 425763 [Multi-domain]  Cd Length: 124  Bit Score: 37.97  E-value: 7.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488945094   65 EGKVLMFDFFGT-FCTPCKEEALDLSKLWKNNSSK-FIIIGLTHfeDvSDETVKKFADDYG 123
Cdd:pfam00578  24 RGKWVVLFFYPAdWTPVCTTELPALADLYEEFKKLgVEVLGVSV--D-SPESHKAFAEKYG 81
PRK03147 PRK03147
thiol-disulfide oxidoreductase ResA;
65-123 2.84e-03

thiol-disulfide oxidoreductase ResA;


Pssm-ID: 179545 [Multi-domain]  Cd Length: 173  Bit Score: 36.90  E-value: 2.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488945094  65 EGKVLMFDFFGTFCTPCKEEALDLSKLWKNNSSKFI-IIGLTHFEdvSDETVKKFADDYG 123
Cdd:PRK03147  60 KGKGVFLNFWGTWCKPCEKEMPYMNELYPKYKEKGVeIIAVNVDE--TELAVKNFVNRYG 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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