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Conserved domains on  [gi|488949127|ref|WP_002860202|]
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MULTISPECIES: aspartate carbamoyltransferase catalytic subunit [Campylobacter]

Protein Classification

aspartate carbamoyltransferase catalytic subunit( domain architecture ID 11479270)

aspartate carbamoyltransferase catalytic subunit catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoyl-L-aspartate, the first unique step of pyrimidine biosynthesis

CATH:  3.40.50.1370
EC:  2.1.3.2
Gene Ontology:  GO:0004070|GO:0006520|GO:0016597|GO:0016743|GO:0006207
PubMed:  8725005|8098212
SCOP:  4000794

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
1-294 1.08e-147

aspartate carbamoyltransferase catalytic subunit;


:

Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 416.40  E-value: 1.08e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD-----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PRK00856   5 MKHLLSIEDLSREEIELLLDTAEEFKEvlrreVKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVG 155
Cdd:PRK00856  85 SKGETLADTIRTLSAMGADAIVIRHPQSGAARLLAESSDVPVINAGDGSHQHPTQALLDLLTIREEF-GRLEGLKVAIVG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 156 DIKNSRVAASNIELLSRFNLDITLVAPPHFMPNT--HLKKHYKLDEnIIANSDIIMSLRTQTERHNKTVYASLKDYANDF 233
Cdd:PRK00856 164 DIKHSRVARSNIQALTRLGAEVRLIAPPTLLPEGmpEYGVHTDLDE-VIEDADVVMMLRVQKERMDGGLLPSYEEYKRSY 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488949127 234 CIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENE 294
Cdd:PRK00856 243 GLTAERLAlaKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGRL 305
 
Name Accession Description Interval E-value
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
1-294 1.08e-147

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 416.40  E-value: 1.08e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD-----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PRK00856   5 MKHLLSIEDLSREEIELLLDTAEEFKEvlrreVKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVG 155
Cdd:PRK00856  85 SKGETLADTIRTLSAMGADAIVIRHPQSGAARLLAESSDVPVINAGDGSHQHPTQALLDLLTIREEF-GRLEGLKVAIVG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 156 DIKNSRVAASNIELLSRFNLDITLVAPPHFMPNT--HLKKHYKLDEnIIANSDIIMSLRTQTERHNKTVYASLKDYANDF 233
Cdd:PRK00856 164 DIKHSRVARSNIQALTRLGAEVRLIAPPTLLPEGmpEYGVHTDLDE-VIEDADVVMMLRVQKERMDGGLLPSYEEYKRSY 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488949127 234 CIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENE 294
Cdd:PRK00856 243 GLTAERLAlaKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGRL 305
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 1-294 6.14e-141

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 399.04  E-value: 6.14e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSS 76
Cdd:COG0540    5 MRHLLSIEDLSREEIEELLDTAEEFKEvlrpIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSVS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVGD 156
Cdd:COG0540   85 KGESLADTIRTLEAYGADAIVIRHPQEGAARLLAEHVDVPVINAGDGAHEHPTQALLDLYTIREEF-GRLDGLKVAIVGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 157 IKNSRVAASNIELLSRFNLDITLVAPPHFMPNT----HLKKHYKLDEnIIANSDIIMSLRTQTERHNKTVYASLKDYAND 232
Cdd:COG0540  164 LKHSRVARSNIKALSKLGAEVTLVAPPTLLPEEieelGVEVTTDLDE-ALPDADVVYMLRIQKERFTDGLFPSYREYKRS 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488949127 233 FCIQKSLVKD--KKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENE 294
Cdd:COG0540  243 YGLTAERLALakPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGEE 306
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 2-291 1.76e-102

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 301.59  E-value: 1.76e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127    2 RHLITTKDFNKVEIMELFKEA----SDFLDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS-S 76
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETAreleQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSvA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   77 KGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVGD 156
Cdd:TIGR00670  81 KGETLADTIKTLSGYV-DAIVIRHPLEGAARLAAEVSEVPVINAGDGSNQHPTQTLLDLYTIYEEF-GRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  157 IKNSRVAASNIELLSRFNLDITLVAPPHFM-----------PNTHLKKHYKLDEnIIANSDIIMSLRTQTERHNktVYAS 225
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRFGVEVYLISPEELRmpkeileelkaKGIKVRETESLEE-VIDEADVLYVTRIQKERFP--DPEE 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488949127  226 LKDYANDFCIQKSLVKDKK--LILLHPGPvnRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLIL 291
Cdd:TIGR00670 236 YEKVKGSYGITLERLEAAKkgVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
3-139 7.99e-55

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 174.15  E-value: 7.99e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127    3 HLITTKDFNKVEIMELFKEASDF----LDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSKG 78
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELkearKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488949127   79 ETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGdGKHAHPTQALLDLFTIY 139
Cdd:pfam02729  81 ESLADTARVLSRYV-DAIVIRHFGHEDLEELAEYASVPVINAG-GDHEHPTQALADLLTIR 139
 
Name Accession Description Interval E-value
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
1-294 1.08e-147

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 416.40  E-value: 1.08e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD-----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PRK00856   5 MKHLLSIEDLSREEIELLLDTAEEFKEvlrreVKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVG 155
Cdd:PRK00856  85 SKGETLADTIRTLSAMGADAIVIRHPQSGAARLLAESSDVPVINAGDGSHQHPTQALLDLLTIREEF-GRLEGLKVAIVG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 156 DIKNSRVAASNIELLSRFNLDITLVAPPHFMPNT--HLKKHYKLDEnIIANSDIIMSLRTQTERHNKTVYASLKDYANDF 233
Cdd:PRK00856 164 DIKHSRVARSNIQALTRLGAEVRLIAPPTLLPEGmpEYGVHTDLDE-VIEDADVVMMLRVQKERMDGGLLPSYEEYKRSY 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488949127 234 CIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENE 294
Cdd:PRK00856 243 GLTAERLAlaKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGRL 305
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 1-294 6.14e-141

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 399.04  E-value: 6.14e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSS 76
Cdd:COG0540    5 MRHLLSIEDLSREEIEELLDTAEEFKEvlrpIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTSSVS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVGD 156
Cdd:COG0540   85 KGESLADTIRTLEAYGADAIVIRHPQEGAARLLAEHVDVPVINAGDGAHEHPTQALLDLYTIREEF-GRLDGLKVAIVGD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 157 IKNSRVAASNIELLSRFNLDITLVAPPHFMPNT----HLKKHYKLDEnIIANSDIIMSLRTQTERHNKTVYASLKDYAND 232
Cdd:COG0540  164 LKHSRVARSNIKALSKLGAEVTLVAPPTLLPEEieelGVEVTTDLDE-ALPDADVVYMLRIQKERFTDGLFPSYREYKRS 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488949127 233 FCIQKSLVKD--KKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENE 294
Cdd:COG0540  243 YGLTAERLALakPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGEE 306
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 2-291 1.76e-102

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 301.59  E-value: 1.76e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127    2 RHLITTKDFNKVEIMELFKEA----SDFLDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS-S 76
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETAreleQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSvA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   77 KGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVGD 156
Cdd:TIGR00670  81 KGETLADTIKTLSGYV-DAIVIRHPLEGAARLAAEVSEVPVINAGDGSNQHPTQTLLDLYTIYEEF-GRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  157 IKNSRVAASNIELLSRFNLDITLVAPPHFM-----------PNTHLKKHYKLDEnIIANSDIIMSLRTQTERHNktVYAS 225
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRFGVEVYLISPEELRmpkeileelkaKGIKVRETESLEE-VIDEADVLYVTRIQKERFP--DPEE 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488949127  226 LKDYANDFCIQKSLVKDKK--LILLHPGPvnRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLIL 291
Cdd:TIGR00670 236 YEKVKGSYGITLERLEAAKkgVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
pyrB PRK13814
aspartate carbamoyltransferase;
3-293 4.93e-59

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 191.09  E-value: 4.93e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   3 HLITTKDFNKVEIMELFKEASDFLD---EKPRTF--LEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSK 77
Cdd:PRK13814   7 HLLNMRSLTRDHIEKLIQRANYFLTqgmEKNSVFetLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  78 GETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVV-NGGDGKHAHPTQALLDLFTIYNHfqgSVEGKKIC--IV 154
Cdd:PRK13814  87 GETLFDTIKTLEAMGVYFFIVRHSENETPEQIAKQLSSGVViNAGDGNHQHPSQALIDLMTIKQH---KPHWNKLCvtII 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 155 GDIKNSRVAASNIELLSRFNL-DITLVAPPHFMP----NTHLKKHYKLDENIIaNSDIIMSLRTQTERHNKTVYASLKDY 229
Cdd:PRK13814 164 GDIRHSRVANSLMDGLVTMGVpEIRLVGPSSLLPdkvgNDSIKKFTELKPSLL-NSDVIVTLRLQKERHDNSVDIDAFRG 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488949127 230 ANDFCIQKSLVKDKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILEN 293
Cdd:PRK13814 243 SFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVLELFLLRD 306
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
3-139 7.99e-55

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 174.15  E-value: 7.99e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127    3 HLITTKDFNKVEIMELFKEASDF----LDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSKG 78
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELkearKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488949127   79 ETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGdGKHAHPTQALLDLFTIY 139
Cdd:pfam02729  81 ESLADTARVLSRYV-DAIVIRHFGHEDLEELAEYASVPVINAG-GDHEHPTQALADLLTIR 139
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 3-290 2.88e-47

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 163.50  E-value: 2.88e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   3 HLITTKDFNKVEIMELFKEASDFLD----EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVL-RLDVSRSSSSK 77
Cdd:PRK11891  89 QLLSVDQFSRDSVEALFRVADVMQPiarrQKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCdTTGFTFSSMAK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  78 GETLYDTAAnldAMS--PNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHF---QGSVEGKKIC 152
Cdd:PRK11891 169 GESIYDTSR---VMSgyVDALVIRHPEQGSVAEFARATNLPVINGGDGPGEHPSQALLDLYTIQREFsrlGKIVDGAHIA 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 153 IVGDIKNSRVAASNIELLSRFN-LDITLVAPPHF-MP---------NTHLKKHYKLDENIIANSDIIMSLRTQTERHNKt 221
Cdd:PRK11891 246 LVGDLKYGRTVHSLVKLLALYRgLKFTLVSPPTLeMPayiveqisrNGHVIEQTDDLAAGLRGADVVYATRIQKERFAD- 324

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488949127 222 vyASLKDYANDFCIQKSLVKD---KKLILLHPGPVNRN---IDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLI 290
Cdd:PRK11891 325 --ESFEGYTPDFQINQALVDAvckPDTLIMHPLPRDSRpgaNDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLL 397
PLN02527 PLN02527
aspartate carbamoyltransferase
 3-291 2.99e-47

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 160.30  E-value: 2.99e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   3 HLITTKDFNKVEIMELFKEASDFLDEKP----RTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSR--SSSS 76
Cdd:PLN02527   2 DVIEAQQFDREMLELLFEVAREMEKVERgspgSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAGefSSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFqGSVEGKKICIVGD 156
Cdd:PLN02527  82 KGETLEDTIRTVEGYS-DIIVLRHFESGAARRAAATAEIPVINAGDGPGQHPTQALLDVYTIQREI-GRLDGIKVGLVGD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 157 IKNSRVAASNIELLSRF-NLDITLVAPPHFMPNTHLKKHykLDEN------------IIANSDIIMSLRTQTERHNKtvy 223
Cdd:PLN02527 160 LANGRTVRSLAYLLAKYeDVKIYFVAPDVVKMKDDIKDY--LTSKgveweessdlmeVASKCDVLYQTRIQRERFGE--- 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488949127 224 aSLKDYA---NDFCIQKSL--VKDKKLILLHPGPvnRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLIL 291
Cdd:PLN02527 235 -RIDLYEaarGKYIVDKKVmdVLPKHAVVMHPLP--RLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLLG 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 1-290 7.56e-47

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 159.45  E-value: 7.56e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLDEK----PRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSS 76
Cdd:COG0078    5 GRHFLSLLDLTPEELRALLDLAAELKAKRkagiPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSpNAIVVR-HANSGVpLILAKHMHCPVVNG-GDgkHAHPTQALLDLFTIYNHFqGSVEGKKICIV 154
Cdd:COG0078   85 RGESIKDTARVLSRYV-DGIMIRtFGHETL-EELAKYAGVPVINGlTD--LFHPCQALADLLTIREHF-GKLKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 155 GDIKNsrVAASNIELLSRFNLDITLVAPPHFMPNTHLKK-----------HYKLDENI---IANSDII-----MSL---R 212
Cdd:COG0078  160 GDGNN--VANSLLLAAAKLGMDVRIATPEGYEPDPEIVAkakeiaaesggSITITHDPaeaVKGADVVytdvwVSMgqeE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 213 TQTERHNKtvyasLKDYandfCIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNgvaiRM----AVL 286
Cdd:COG0078  238 EAEERIKA-----FKPY----QVNEELMAlaKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAEN----RLhaqkALL 304


                 ....
gi 488949127 287 KKLI 290
Cdd:COG0078  305 AWLL 308
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 3-284 6.02e-45

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 155.27  E-value: 6.02e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   3 HLITTKDFNKVEIMELFKEASDF----LDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVlRLDVSRSSSS-- 76
Cdd:PRK08192   7 HILSVNQLDRDAIQRIFNVADRMepyaLREKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHV-RETTGMASSSls 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIY---NHFQGSVEGKKICI 153
Cdd:PRK08192  86 KGESLYDTARVLSTYS-DVIAMRHPDAGSVKEFAEGSRVPVINGGDGSNEHPTQALLDLFTIQkelAHAGRGIDGMHIAM 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 154 VGDIKNSRVAASNIELLSRF-NLDITLVAPPHF-MPNTHL----KKHYKLD-----ENIIANSDIIMSLRTQTERHNKTV 222
Cdd:PRK08192 165 VGDLKFGRTVHSLSRLLCMYkNVSFTLVSPKELaMPDYVIsdieNAGHKITitdqlEGNLDKADILYLTRIQEERFPSQE 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488949127 223 YASLkdYANDFCIQKSLVK---DKKLILLHPGPVNRNID---ISDEMMSDERTLVLKQVKNGVAIRMA 284
Cdd:PRK08192 245 EANK--YRGKFRLNQSIYTqhcKSNTVIMHPLPRDSRAQaneLDNDLNSHPNLAIFRQADNGLLIRMA 310
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 1-290 8.69e-37

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 132.91  E-value: 8.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDF----LDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSS 76
Cdd:PRK00779   4 GRHFLSLDDLSPEELEELLDLAAELkkkrKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETLYDTAANLDAMSpNAIVVR-HANSGVpLILAKHMHCPVVNG-GDgkHAHPTQALLDLFTIYNHFqGSVEGKKICIV 154
Cdd:PRK00779  84 RGEPIEDTARVLSRYV-DAIMIRtFEHETL-EELAEYSTVPVINGlTD--LSHPCQILADLLTIYEHR-GSLKGLKVAWV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 155 GDIKNsrVAASNIELLSRFNLDITLVAPPHFMPNTHLKK--------HYKLDEN---IIANSDII-------MSLRTQTE 216
Cdd:PRK00779 159 GDGNN--VANSLLLAAALLGFDLRVATPKGYEPDPEIVEkiaketgaSIEVTHDpkeAVKGADVVytdvwvsMGQEAEAE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 217 RHnktvyasLKDYAnDFCIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNgvaiRM----AVLKKLI 290
Cdd:PRK00779 237 ER-------LKAFA-PYQVNEELMAlaKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAEN----RLhaqkALLAWLL 304
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 2-290 3.27e-36

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 131.32  E-value: 3.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127    2 RHLITTKDFNKVEIMELFKEASDFLDE----KPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSK 77
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGkkkgKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   78 GETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKhAHPTQALLDLFTIYNHFqGSVEGKKICIVGDI 157
Cdd:TIGR00658  81 GESIKDTARVLSRYV-DGIMARVYKHEDVEELAKYASVPVINGLTDL-FHPCQALADLLTIIEHF-GKLKGVKVVYVGDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  158 KNsrVAASNIELLSRFNLDITLVAPPHFMPNTHLKKHYK-----------LDENII---ANSDIIMslrTQT------ER 217
Cdd:TIGR00658 158 NN--VCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQeiakenggsveLTHDPVeavKGADVIY---TDVwvsmgeED 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488949127  218 HNKTVYASLKDYAndfcIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLI 290
Cdd:TIGR00658 233 KKEERLKLFRPYQ----VNEELMElaKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALL 303
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 2-188 7.99e-28

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 109.59  E-value: 7.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   2 RHLITTKDFNKVEIMELFKEASDFLDEK----PRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSK 77
Cdd:PRK02102   8 RSFLKLLDFTPEEIEYLIDLSIELKAAKkagiEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQLGK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  78 GETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFqGSVEGKKICIVGDI 157
Cdd:PRK02102  88 KESIEDTARVLGRMY-DGIEYRGFKQEIVEELAKYSGVPVWNGLTDEW-HPTQMLADFMTMKEHF-GPLKGLKLAYVGDG 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 488949127 158 KNSrVAASNIELLSRFNLDITLVAPPHFMPN 188
Cdd:PRK02102 165 RNN-MANSLMVGGAKLGMDVRICAPKELWPE 194
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 1-290 2.28e-26

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 105.16  E-value: 2.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLD--EKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSKG 78
Cdd:PRK14805   1 MKHLLSIKELTQQQLLDLLALAKTIKAnpAEYRQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  79 ETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFqGSVEGKKICIVGDIK 158
Cdd:PRK14805  81 ESVADFAANLSCWA-DAIVARVFSHSTIEQLAEHGSVPVINALCDLY-HPCQALADFLTLAEQF-GDVSKVKLAYVGDGN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 159 NsrVAASNIELLSRFNLDITLVAPPHFMPNTHL-------------KKHYKLDENIIANSDIIMSlRTQTERHNKTVYAS 225
Cdd:PRK14805 158 N--VTHSLMYGAAILGATMTVICPPGHFPDGQIvaeaqelaaksggKLVLTSDIEAIEGHDAIYT-DTWISMGDDTPLAE 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488949127 226 LKDYANDFCIQKSLV-KDKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLI 290
Cdd:PRK14805 235 IKAKFAPYQVNKALMeKAGATFVMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLL 300
PLN02342 PLN02342
ornithine carbamoyltransferase
 1-286 9.44e-25

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 101.79  E-value: 9.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEAS---DFLDEKPRTF--LEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PLN02342  45 PKHFLHIDDFDKEEILGLLDRAKevkALLKSGDRSFqpFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSpNAIVVR-HANSGVpLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFqGSVEGKKICIV 154
Cdd:PLN02342 125 GKREETRDIARVLSRYN-DIIMARvFAHQDV-LDLAEYSSVPVINGLTDYN-HPCQIMADALTIIEHI-GRLEGTKVVYV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 155 GDIKNsrVAASNIELLSRFNLDITLVAPPHFMPN-----------------THLKKHYKLDENIIAnSDIIMSLRTQTEr 217
Cdd:PLN02342 201 GDGNN--IVHSWLLLAAVLPFHFVCACPKGYEPDaktvekaraagiskieiTNDPAEAVKGADVVY-TDVWASMGQKEE- 276

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488949127 218 hnktvYASLKDYANDFCIQKSLVK--DKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVL 286
Cdd:PLN02342 277 -----AEKRKKAFQGFQVNEALMKlaGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIM 342
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 2-207 5.29e-24

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 99.40  E-value: 5.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   2 RHLITTKDFNKVEIMELFKEASDF-LDEKPRT---FLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSK 77
Cdd:PRK03515   7 RHFLRLLDFTPAELNSLLQLAAKLkADKKNGKeeqKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  78 GETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFQG-SVEGKKICIVGD 156
Cdd:PRK03515  87 KESIKDTARVLGRMY-DGIQYRGYGQEIVETLAEYAGVPVWNGLTNEF-HPTQLLADLLTMQEHLPGkAFNEMTLAYAGD 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488949127 157 IKNSrVAASNIELLSRFNLDITLVAPPHFMPNTHL-----KKHYKLDENIIANSDI 207
Cdd:PRK03515 165 ARNN-MGNSLLEAAALTGLDLRLVAPKACWPEAALvtecrALAQKNGGNITLTEDI 219
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
150-286 7.99e-23

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 91.90  E-value: 7.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  150 KICIVGDIKNsRVAASNIELLSRFNLDITLVAPPHFMPNTHLKKHYKLD--------------ENIIANSDIIMSLRTQT 215
Cdd:pfam00185   1 KIAYVGDGHN-NVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIaeksggsieitddpAEAVKGADVVYTDVWQS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488949127  216 ERHNKTVYASLKDYAnDFCIQKSLVKD--KKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVL 286
Cdd:pfam00185  80 MGQEKEREERLKAFK-PYQVNEELMKLakKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALL 151
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 1-289 7.45e-22

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 93.27  E-value: 7.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFLDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSS------ 74
Cdd:PRK04523   3 LKHFLNTQDWSRAELDALLTQAAAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDAwpiefe 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  75 ------SSKGETLYDTAANLDAMSpNAIVVRHANSGV--------PLI--LAKHMHCPVVNGGDGkhAHPTQALLDLFTI 138
Cdd:PRK04523  83 lgavmdGETEEHIREVARVLSRYV-DLIGVRAFPKFVdwskdrqdQVLnsFAKYSTVPVINMETI--THPCQELAHALAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 139 YNHFQGSVEGKKICI--VGDIK--NSRVAASNIELLSRFNLDITLVAPPhfmPNTHLKKHY--KLDENIIAN--SDIIMS 210
Cdd:PRK04523 160 QEHFGTTLRGKKYVLtwTYHPKplNTAVANSALLIATRLGMDVTLLCPT---PDYILDERYmdWAEQNAAESggSLTVSH 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 211 LRTQTERHNKTVYAS----------------LKDYANDFCI-QKSLVKDKKLILLHPGPVNRNIDISDEMMSDERTLVLK 273
Cdd:PRK04523 237 DIDSAYAGADVVYAKswgalpffgnwepekpIRDQYQHFIVdERKMALTNNGVFSHCLPLRRNVKVTDAVMDSPNCIAID 316

                        330
                 ....*....|....*.
gi 488949127 274 QVKNGVAIRMAVLKKL 289
Cdd:PRK04523 317 EAENRLHVQKAIMAAL 332
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 2-191 4.10e-20

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 88.65  E-value: 4.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   2 RHLITTKDFNKVEIMELFKEASDFLD------EKPRtfLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PRK04284   7 RSFLTLLDFTPKEIEYLLDLSEDLKRakyagiEVQK--LKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGSQM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKhAHPTQALLDLFTIYNHFQGSVEGKKICIVG 155
Cdd:PRK04284  85 GKKESTKDTARVLGGMY-DGIEYRGFSQRTVETLAEYSGVPVWNGLTDE-DHPTQVLADFLTAKEHLKKPYKDIKFTYVG 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 488949127 156 DIKNSrVAASNIELLSRFNLDITLVAPPHFMPNTHL 191
Cdd:PRK04284 163 DGRNN-VANALMQGAAIMGMDFHLVCPKELNPDDEL 197
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 39-200 3.07e-18

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 84.43  E-value: 3.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  39 ITTIFFENSTRTLSSFESAAR-RLGARVLRLDVSRSSSSKGETLYDTAANLDAMSPNAI-VVRHANSGVPLILAKHM--- 113
Cdd:PRK13376  53 IYIVFVEPSTRTKESFINAAKfHKNVKVNIFDSEHSSFNKQESYTDTFNMLTGYSDYSIfIVRTRLEGVCRLLEEKVsef 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 114 -------HCPVVNGGDGKHAHPTQALLDLFTIYNHFQGSVEGKKICIVGDIKNSRVAASNIELLSRF-NLDITLVAPPHF 185
Cdd:PRK13376 133 asrngieVPAFINAGDGKHEHPTQELLDEFTFLEQNNFDNSFIHIALVGDLLHGRTVHSKVNGLKIFkNVKVDLIAPEEL 212

                        170
                 ....*....|....*...
gi 488949127 186 -MPnthlkKHY--KLDEN 200
Cdd:PRK13376 213 aMP-----EHYveKMKKN 225
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 2-291 3.84e-18

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 83.18  E-value: 3.84e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   2 RHLITTKDFNKVEIMELFKEAS----DFLDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSK 77
Cdd:PRK12562   7 KHFLKLLDFTPAELNSLLQLAAklkaDKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  78 GETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFQG-SVEGKKICIVGD 156
Cdd:PRK12562  87 KESIKDTARVLGRMY-DGIQYRGHGQEVVETLAEYAGVPVWNGLTNEF-HPTQLLADLLTMQEHLPGkAFNEMTLVYAGD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 157 IKNSrVAASNIELLSRFNLDITLVAPPHFMPNTHL--------KKH---YKLDENIIAN--------SDIIMSLRTQTER 217
Cdd:PRK12562 165 ARNN-MGNSMLEAAALTGLDLRLVAPQACWPEASLvaecsalaQKHggkITLTEDIAAGvkgadfiyTDVWVSMGEPKEK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 218 HNKTVyASLKDYANDFCIQkSLVKDKKLILLHPGP------------------VNRNIDISDEMMSDERTLVLKQVKNgv 279
Cdd:PRK12562 244 WAERI-ALLRGYQVNSKMM-ALTGNPQVKFLHCLPafhddqttlgkkmakefgLHGGMEVTDEVFESPASIVFDQAEN-- 319

                        330
                 ....*....|..
gi 488949127 280 aiRMAVLKKLIL 291
Cdd:PRK12562 320 --RMHTIKAVMV 329
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 2-191 8.67e-18

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 81.96  E-value: 8.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   2 RHLITTKDFNKVEIMELFKEASDFL------DEKPRtfLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSS 75
Cdd:PRK01713   8 RHLLSLVNHTEREIKYLLDLSRDLKrakyagTEQQR--LKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  76 SKGETLYDTAANLDAMSpNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTIYNHFQGSVEGKKICIVG 155
Cdd:PRK01713  86 GHKESMKDTARVLGRMY-DAIEYRGFKQSIVNELAEYAGVPVFNGLTDEF-HPTQMLADVLTMIENCDKPLSEISYVYIG 163

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 488949127 156 DIKNSrVAASNIELLSRFNLDITLVAPPHFMPNTHL 191
Cdd:PRK01713 164 DARNN-MGNSLLLIGAKLGMDVRICAPKALLPEASL 198
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 1-293 2.70e-17

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 80.46  E-value: 2.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127   1 MRHLITTKDFNKVEIMELFKEASDFldEKPRTF----LEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSS 76
Cdd:PRK14804   6 VKHLISWEDWSDSEILDLLDFAVHV--KKNRVNyaghMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  77 KGETlyDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHaHPTQALLDLFTI-YNHFQGSVEGKKICIVG 155
Cdd:PRK14804  84 LSDI--DLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMF-HPCQSLADIMTIaLDSPEIPLNQKQLTYIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 156 DIKNsrVAASNIELLSRFNLDITLVAPPHFMPNTH--------LKKHYKLDENI---IANSDIIMS-LRTQTERHNKTVY 223
Cdd:PRK14804 161 VHNN--VVNSLIGITAALGIHLTLVTPIAAKENIHaqtverakKKGTLSWEMNLhkaVSHADYVYTdTWLDMEFFNDPSY 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488949127 224 ASLKDYAND----FCIQKSLVKDKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLiLEN 293
Cdd:PRK14804 239 ADKKKQRMElmmpYQINSSLMEKTNAKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVILKL-LEN 311
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 30-182 1.44e-10

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 61.29  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127  30 PRTFLEGKSITtIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSKGETLYDTaANLDAMSPNAIVVR--------HA 101
Cdd:PRK07200  54 TKVFNSGLGIS-VFRDNSTRTRFSYASACNLLGLEVQDLDEGKSQIAHGETVRET-ANMISFMADVIGIRddmyigkgNA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488949127 102 -------------NSGV----PLILakHMHCPVvnggdgkhAHPTQALLDLFTIYNHFqGSVE---GKKICIVGDIKNS- 160
Cdd:PRK07200 132 ymrevgaavddgyKQGVlpqrPTLV--NLQCDI--------DHPTQSMADLLHLIEHF-GGLEnlkGKKIAMTWAYSPSy 200

                        170       180
                 ....*....|....*....|....*.
gi 488949127 161 ----RVAASNIELLSRFNLDITLVAP 182
Cdd:PRK07200 201 gkplSVPQGIIGLMTRFGMDVTLAHP 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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