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Conserved domains on  [gi|488971578|ref|WP_002882510|]
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MULTISPECIES: transcriptional regulator AsnC [Klebsiella]

Protein Classification

transcriptional regulator AsnC( domain architecture ID 11485253)

transcriptional regulator AsnC acts as an autogenously regulated activator of asparagine synthetase A transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 1.99e-116

DNA-binding transcriptional regulator AsnC; Provisional


:

Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 325.13  E-value: 1.99e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   1 MENYQIDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578  81 DYPSALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179  82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 1.99e-116

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 325.13  E-value: 1.99e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   1 MENYQIDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578  81 DYPSALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179  82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-142 1.55e-46

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 147.62  E-value: 1.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   4 YQIDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSaKDYP 83
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488971578  84 SALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVL 142
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-113 2.46e-38

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 126.09  E-value: 2.46e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578     6 IDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSA 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 488971578    86 LARLESLEEVTEAYYTTGHYSIFIKVMC 113
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 1.87e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.79  E-value: 1.87e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578   72 IGIILKSAKDYPSALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQ 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-56 1.19e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.13  E-value: 1.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971578   7 DNLDRGILDALMANARTAyAELAKQFSVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:cd00090    6 DPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 1.99e-116

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 325.13  E-value: 1.99e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   1 MENYQIDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578  81 DYPSALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179  82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-142 1.55e-46

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 147.62  E-value: 1.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   4 YQIDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSaKDYP 83
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488971578  84 SALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVL 142
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-113 2.46e-38

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 126.09  E-value: 2.46e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578     6 IDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSA 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 488971578    86 LARLESLEEVTEAYYTTGHYSIFIKVMC 113
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 1.87e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.79  E-value: 1.87e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578   72 IGIILKSAKDYPSALARLESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQ 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
7-47 2.65e-12

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 57.76  E-value: 2.65e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 488971578    7 DNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMK 47
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
9-52 2.45e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 50.12  E-value: 2.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 488971578    9 LDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGII 52
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-143 7.77e-09

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 51.69  E-value: 7.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971578   6 IDNLDRGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILksAKDYPSA 85
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITL--NRGAPDV 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971578  86 LAR----LESLEEVTEAYYTTGHYSIFIKVMCKSIDALQQVLINKIQTIDEIQSTETLIVLQ 143
Cdd:PRK11169  90 FEQfnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVME 151
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 11-56 4.36e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 41.76  E-value: 4.36e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 488971578   11 RGILDALMANARTAYAELAKQFSVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-56 1.19e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.13  E-value: 1.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971578   7 DNLDRGILDALMANARTAyAELAKQFSVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:cd00090    6 DPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
11-56 1.69e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 38.86  E-value: 1.69e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488971578  11 RGILDALMANARTAYaELAKQFSVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:COG1777   20 RRILALLSEEPAYVS-ELARELGVSRQAVYKHLRKLEEAGLVESYR 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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