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Conserved domains on  [gi|488971608|ref|WP_002882540|]
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MULTISPECIES: FadR/GntR family transcriptional regulator [Klebsiella]

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-225 7.26e-59

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 185.52  E-value: 7.26e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  89 eLLSWWLTEDnfEEVVSHFLVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALD--DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608 169 GNPFLSSFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILNSDAPGALLACQALL 225
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHL 216
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-225 7.26e-59

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 185.52  E-value: 7.26e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  89 eLLSWWLTEDnfEEVVSHFLVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALD--DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608 169 GNPFLSSFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILNSDAPGALLACQALL 225
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHL 216
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
1-226 3.09e-23

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 93.93  E-value: 3.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   1 MSLSAQQLAAQKnISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLL----PRPRIgTR 76
Cdd:PRK03837   2 RNLRSRPIARKK-LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgERARV-SR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  77 VMPRSSWNFLD---KELLSwwLTEDNFEevvsHFLVMRSSLEPQACFLAAANGTAGQKAQLntlmEEMIALKRHF--QRE 151
Cdd:PRK03837  80 PSADTIIGQLSgmaKDFLS--QSPDGLA----HLKQARLFFESSLARYAAEHATDEQIALL----RKALERNSQSlgDNA 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488971608 152 RWIEVDMAWHEHIYEMSGNP-FLSSFASLFH--SVYHTYFTSITQNEVVKLDLHQAIVDAILNSDAPGALLACQALLN 226
Cdd:PRK03837 150 AFIRSDMEFHRVIAEIPGNPiFMAIHEALLDwlIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
110-227 2.56e-21

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 85.49  E-value: 2.56e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   110 MRSSLEPQACFLAAANGTAGQKAQLNTLMEEM-IALKRHFQRERWIEVDMAWHEHIYEMSGNPFLSSFASLFHSVYHTYF 188
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMeAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 488971608   189 TSITQNEVVKLDLHQAIVDAILNSDAPGALLACQALLNA 227
Cdd:smart00895  85 RLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
18-77 4.34e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 4.34e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
108-223 1.41e-19

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 80.88  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  108 LVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHFQRERWIEVDMAWHEHIYEMSGNPFLSSFASLFHSVYHTY 187
Cdd:pfam07729   3 YELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRL 82
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 488971608  188 FTSITQNE---VVKLDLHQAIVDAILNSDAPGALLACQA 223
Cdd:pfam07729  83 RRLLLSSPgrlRASLEEHRAILDAIRARDPEAARAAMRR 121
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
18-80 5.08e-11

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 60.57  E-value: 5.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488971608   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPR 80
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-225 7.26e-59

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 185.52  E-value: 7.26e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPRSSWNFLDk 88
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  89 eLLSWWLTEDnfEEVVSHFLVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHfqRERWIEVDMAWHEHIYEMS 168
Cdd:COG2186   82 -PLALLLALD--DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEAS 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608 169 GNPFLSSFASLFHSVYHTYFTSITQNEVVK---LDLHQAIVDAILNSDAPGALLACQALL 225
Cdd:COG2186  157 GNPLLALLLESLRELLRRSVRLTLRSPEARersLAEHRAILDAIRAGDPEAARAAMRAHL 216
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
19-225 1.95e-35

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 125.03  E-value: 1.95e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  19 AEKLAQKILTGEYQPESILPgEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPrsswnfldkellswwLTED 98
Cdd:COG1802   17 YEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP---------------LSPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  99 NFEEVvshfLVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHFQRERWIEVDMAWHEHIYEMSGNPFLSSFAS 178
Cdd:COG1802   81 EIREL----YEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLR 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971608 179 LFHSVYHTY-FTSITQNEVVK--LDLHQAIVDAILNSDAPGALLACQALL 225
Cdd:COG1802  157 RLRARLRRYrRLSLRSPGRLEesLAEHRAILDALEAGDAEAAAAALRAHL 206
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
1-226 3.09e-23

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 93.93  E-value: 3.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   1 MSLSAQQLAAQKnISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLL----PRPRIgTR 76
Cdd:PRK03837   2 RNLRSRPIARKK-LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgERARV-SR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  77 VMPRSSWNFLD---KELLSwwLTEDNFEevvsHFLVMRSSLEPQACFLAAANGTAGQKAQLntlmEEMIALKRHF--QRE 151
Cdd:PRK03837  80 PSADTIIGQLSgmaKDFLS--QSPDGLA----HLKQARLFFESSLARYAAEHATDEQIALL----RKALERNSQSlgDNA 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488971608 152 RWIEVDMAWHEHIYEMSGNP-FLSSFASLFH--SVYHTYFTSITQNEVVKLDLHQAIVDAILNSDAPGALLACQALLN 226
Cdd:PRK03837 150 AFIRSDMEFHRVIAEIPGNPiFMAIHEALLDwlIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLN 227
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
110-227 2.56e-21

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 85.49  E-value: 2.56e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   110 MRSSLEPQACFLAAANGTAGQKAQLNTLMEEM-IALKRHFQRERWIEVDMAWHEHIYEMSGNPFLSSFASLFHSVYHTYF 188
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMeAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 488971608   189 TSITQNEVVKLDLHQAIVDAILNSDAPGALLACQALLNA 227
Cdd:smart00895  85 RLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
18-77 4.34e-21

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 4.34e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
108-223 1.41e-19

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 80.88  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  108 LVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHFQRERWIEVDMAWHEHIYEMSGNPFLSSFASLFHSVYHTY 187
Cdd:pfam07729   3 YELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRL 82
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 488971608  188 FTSITQNE---VVKLDLHQAIVDAILNSDAPGALLACQA 223
Cdd:pfam07729  83 RRLLLSSPgrlRASLEEHRAILDAIRARDPEAARAAMRR 121
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
18-77 5.64e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 77.65  E-value: 5.64e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
18-80 4.49e-18

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 79.91  E-value: 4.49e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPR 80
Cdd:COG2188   10 IADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEP 72
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-77 1.66e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 73.76  E-value: 1.66e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608    18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
18-220 1.05e-11

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 62.48  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTrvmprsswnFLDKELLSWwlTE 97
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGT---------FIRWRHETW--SE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  98 DNFEEVVSHF-----------LVMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHFQRerwiEVDMAWHEHIYE 166
Cdd:PRK10421  76 QNIVQPLKTLmaddpdysfdiLEARHAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDLAS----QADVRFHLAIAE 151
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488971608 167 MSGNPFL-----SSFASLFHSVYHTYFTSITQNEVVKL--DLHQAIVDAILNSDAPGALLA 220
Cdd:PRK10421 152 ASHNVVLlqtmrGFFDVLQSSVKQSRQRMYLVPPVFSQltEQHQAVMDAILAGDAEGARKA 212
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
11-127 1.58e-11

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 61.96  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  11 QKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVmprsswnfldKEL 90
Cdd:PRK09464   8 QPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV----------QSS 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 488971608  91 LSWWLTEDNFEEVVSH------FLVMRSSLEPQACFLAAANGT 127
Cdd:PRK09464  78 LWQSFSDPLVELLSDHpesqfdLLETRHALEGIAAYYAALRGT 120
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
18-80 5.08e-11

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 60.57  E-value: 5.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488971608   18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPR 80
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
9-185 2.24e-10

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 58.62  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608   9 AAQKNISWVLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGML------------LPRPRIGTR 76
Cdd:PRK09990   3 DERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIetaqgrgsfvarLNRVQDASP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  77 VM------PRSSWNFLDkellswwltednfeevvshflvMRSSLEPQACFLAAANGTAGQKAQLNTLMEEMIALKRHFQR 150
Cdd:PRK09990  83 LMhlfssqPRTLYDLLE----------------------VRALLEGESARLAALRGTQADFVLITRRYEEMLAAHENNKE 140
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971608 151 ERWIE---VDMAWHEHIYEMSGNPF----LSS-----FASLFHSV---YH 185
Cdd:PRK09990 141 IDPIEharLDHAFHLAICEASHNPVlvhtLQSltdlmLSSVFASVnnlYH 190
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
18-80 6.48e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 58.30  E-value: 6.48e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPR 80
Cdd:COG1167   17 LADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
PRK09764 PRK09764
GntR family transcriptional regulator;
18-67 4.93e-07

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 49.06  E-value: 4.93e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGML 67
Cdd:PRK09764  10 IADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQIL 59
PRK11402 PRK11402
transcriptional regulator PhoB;
4-77 1.55e-06

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 47.52  E-value: 1.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488971608   4 SAQQLAAQkniswvLAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:PRK11402   6 SHQLLYAT------VRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
PRK14999 PRK14999
histidine utilization repressor; Provisional
20-77 2.52e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 46.85  E-value: 2.52e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488971608  20 EKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRV 77
Cdd:PRK14999  19 QDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
PRK10225 PRK10225
Uxu operon transcriptional regulator;
21-220 1.03e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.31  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  21 KLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPRSSWNFLDKELLSWWLTEDNF 100
Cdd:PRK10225  17 MIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSPDANVCNDAGPF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608 101 EevvshFLVMRSSLEPQACFLAAANGTagqkaqlntlMEEMIALKRHFQ-RERWIEV---------DMAWHEHIYEMSGN 170
Cdd:PRK10225  97 E-----LLQARQLLESNIAEFAALQAT----------REDIVKMRQALQlEERELASsapgssesgDMQFHLAIAEATHN 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488971608 171 PFLssfASLFHSVY------------HTYFTSITQNEVVKLDlHQAIVDAILNSDAPGALLA 220
Cdd:PRK10225 162 SML---VELFRQSWqwrennpmwiqlHSHLDDSLYRKEWLGD-HKQILAALIKKDARAAKLA 219
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
24-75 1.03e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 42.73  E-value: 1.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488971608  24 QKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGT 75
Cdd:PRK15481  16 QLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGT 67
PRK11523 PRK11523
transcriptional regulator ExuR;
18-78 1.44e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 41.75  E-value: 1.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488971608  18 LAEKLAQKILTGEYQPESILPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVM 78
Cdd:PRK11523  13 LAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVV 73
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
1-56 4.67e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 40.24  E-value: 4.67e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488971608   1 MSLSAQQLAAqkniswvLAEK-LAQKILTGEYQPESILPGEMELGEQFGVSRTAVRE 56
Cdd:PRK04984   1 MVIKAQSPAG-------FAEEyIIESIWNNRFPPGSILPAERELSELIGVTRTTLRE 50
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
6-80 1.05e-03

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 38.99  E-value: 1.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488971608   6 QQLAAQkniswvLAEKLAQKILTGEYqpesiLPGEMELGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPR 80
Cdd:PRK10079  15 QEIAAK------LEQELRQHYRCGDY-----LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMR 78
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
42-66 1.82e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.49  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....*
gi 488971608   42 ELGEQFGVSRTAVREAVKTLTAKGM 66
Cdd:pfam08279  18 ELAEKLGVSRRTIRRDIKILEELGV 42
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
20-217 2.64e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 37.95  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608  20 EKLAQKILTGEYQPESILPGEMeLGEQFGVSRTAVREAVKTLTAKGMLLPRPRIGTRVMPRSswnflDKELLSWWLTEDN 99
Cdd:PRK11534  14 RWLKNDIIRGNFQPDEKLRMSL-LTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMS-----EQELLDIFDARAN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971608 100 FEEVVSHFLVMRSSLEPQACFLAAANGTAgqKAQLNTLMEEMIalkrhfqrERWIEVDMAWHEHIYEMSGNPFLSSFAS- 178
Cdd:PRK11534  88 MEAMLVSLAIARGGDEWEADVLAKAHLLS--KLEACDASEKML--------DEWDLRHQAFHTAIVAGCGSHYLLQMREr 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488971608 179 LFHSVYHTYFTSITQN--EVVKLDL----HQAIVDAILNSDAPGA 217
Cdd:PRK11534 158 LFDLAARYRFIWLRRTvlSVEMLEDkhdqHQTLTAAILARDTARA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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