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Conserved domains on  [gi|488971945|ref|WP_002882873|]
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MULTISPECIES: ABC transporter permease [Klebsiella]

Protein Classification

ABC transporter permease( domain architecture ID 10003058)

ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of one or more from a variety of substrates such as monosaccharide sugars such as xylose, arabinose, and fructose

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  18535149|17723295|25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
 10-331 5.65e-85

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440785  Cd Length: 322  Bit Score: 259.27  E-value: 5.65e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  10 MKNAPAAPSPLRRLLCWEGFLLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMA 89
Cdd:COG1172    1 MSATTTTARSLLRRLLPELGLLLALVLLLVVFSILSPGFLSPGNLSNILRQAAILGILALGMTLVIITGGIDLSVGSVVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  90 LSSTVMGFCAAA-GMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWF 168
Cdd:COG1172   81 LSGVVAALLLVAlGLPILLAILLALLVGALLGLLNGLLVAKLRIPPFIVTLGTMFIARGLALLLTGGRPISGLPDAFRAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 169 GQGYVWGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLG 248
Cdd:COG1172  161 GQGSLLG-IPVPVLIALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGILLAARLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 249 STRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPIITRRM 328
Cdd:COG1172  240 SAQPNAGSGYELDAIAAVVIGGTSLTGGRGSVLGTLLGALILGVLNNGLNLLGVSSYWQQIVKGAIILLAVLLDRLRRRR 319


                 ...
gi 488971945 329 MQR 331
Cdd:COG1172  320 RAR 322
 
Name Accession Description Interval E-value
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
 10-331 5.65e-85

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440785  Cd Length: 322  Bit Score: 259.27  E-value: 5.65e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  10 MKNAPAAPSPLRRLLCWEGFLLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMA 89
Cdd:COG1172    1 MSATTTTARSLLRRLLPELGLLLALVLLLVVFSILSPGFLSPGNLSNILRQAAILGILALGMTLVIITGGIDLSVGSVVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  90 LSSTVMGFCAAA-GMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWF 168
Cdd:COG1172   81 LSGVVAALLLVAlGLPILLAILLALLVGALLGLLNGLLVAKLRIPPFIVTLGTMFIARGLALLLTGGRPISGLPDAFRAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 169 GQGYVWGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLG 248
Cdd:COG1172  161 GQGSLLG-IPVPVLIALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGILLAARLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 249 STRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPIITRRM 328
Cdd:COG1172  240 SAQPNAGSGYELDAIAAVVIGGTSLTGGRGSVLGTLLGALILGVLNNGLNLLGVSSYWQQIVKGAIILLAVLLDRLRRRR 319


                 ...
gi 488971945 329 MQR 331
Cdd:COG1172  320 RAR 322
TM_PBP1_transp_AraH_like cd06579
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the ...
 61-321 3.29e-70

Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.


Pssm-ID: 119321 [Multi-domain]  Cd Length: 263  Bit Score: 219.20  E-value: 3.29e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  61 FTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMGFCAA-AGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITI 139
Cdd:cd06579    1 AAVLGILALGMTLVIITGGIDLSVGSVAALSAVVAALLLVnAGLPIPLAILAALAVGALIGLLNGLLVAYLRIPPFIVTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 140 GTMSLYRGITYILLGDQALNHYPESFAWFGQGYVWGALSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGI 219
Cdd:cd06579   81 GTMFILRGLALLITGGRPISGLPPLFSFFLGGGLILGIPVPVLIALAVALVAWFLLRRTRFGRYLYAVGGNPEAARLSGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 220 NVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSL 299
Cdd:cd06579  161 NVRRVKILAYVLSGLLAGLAGILLAARLGSAQPTAGNGYELDAIAAVVLGGTSLTGGRGSVLGTLLGALLLGVLNNGLNL 240

                        250       260
                 ....*....|....*....|..
gi 488971945 300 LNVPGIVMSVIIGAMLIVVISL 321
Cdd:cd06579  241 LGVSSFWQQIVKGAILLLAVAL 262
araH PRK11285
L-arabinose transporter permease protein; Provisional
 13-333 5.24e-44

L-arabinose transporter permease protein; Provisional


Pssm-ID: 183076 [Multi-domain]  Cd Length: 333  Bit Score: 153.68  E-value: 5.24e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  13 APAAPSPLRRLLCWEGF-LLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALS 91
Cdd:PRK11285  14 AAPPKSRFSLWRIWDQYgMLVVFAVLFIACSLFVPNFASFINMKGLGLAISMIGMVACTMLFCLASGDFDLSVASVVAFA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  92 STVMGFCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWFGQG 171
Cdd:PRK11285  94 GVVTAVVINATESLWLGVAAGLLLGAAVGLVNGFVIARLKINALITTLATMQIVRGLAYIISDGKAVGISDERFFALGYA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 172 YVWGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTR 251
Cdd:PRK11285 174 NFFG-VPAPIWLTVACFVVFGFLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLQGLVSALAGVILASRMTSGQ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 252 PTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIvvisLPIITRRMMQR 331
Cdd:PRK11285 253 PMTSIGFELIVISACVLGGVSLKGGIAKISGVVAGVLILGTVENAMNLLNISPFYQYVVRGLILL----AAVLFDRYKQR 328


                 ..
gi 488971945 332 RR 333
Cdd:PRK11285 329 AK 330
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
 65-318 1.31e-26

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 105.80  E-value: 1.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945   65 AIVVLPMAMLI-IAREIDLSVASTMALSS-TVMGFCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTM 142
Cdd:pfam02653  13 AIAALGLTLIYgIAGVINLGHGGFMMLGAyVAAMLLNLLGPGLWLALPVGILVGAAVGLLIGILTLRLKINEVIITLLLN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  143 SLYRGITYIL----LGDQALNHYPESFAWFGQGYVWGALSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSG 218
Cdd:pfam02653  93 LAALGLALFLvtgiLGGEGGTSGITGPSGFPGAFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRAVGENEEAARAAG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  219 INVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLA-MGWELAVVTMAVLGGVnilggsGSMPGVIIAAFLMGLV-TFG 296
Cdd:pfam02653 173 INVKKLKLLTFVISGALAGLAGALLALYTGVVPPSNFgVGLGLDAIAAVVLGGA------GSPIGVVIGSLIIGLVqSLG 246

                         250       260
                  ....*....|....*....|..
gi 488971945  297 LSLLNVPGIVMSVIIGAMLIVV 318
Cdd:pfam02653 247 LGALGSPPELSLLVLGALLILV 268
 
Name Accession Description Interval E-value
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
 10-331 5.65e-85

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440785  Cd Length: 322  Bit Score: 259.27  E-value: 5.65e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  10 MKNAPAAPSPLRRLLCWEGFLLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMA 89
Cdd:COG1172    1 MSATTTTARSLLRRLLPELGLLLALVLLLVVFSILSPGFLSPGNLSNILRQAAILGILALGMTLVIITGGIDLSVGSVVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  90 LSSTVMGFCAAA-GMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWF 168
Cdd:COG1172   81 LSGVVAALLLVAlGLPILLAILLALLVGALLGLLNGLLVAKLRIPPFIVTLGTMFIARGLALLLTGGRPISGLPDAFRAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 169 GQGYVWGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLG 248
Cdd:COG1172  161 GQGSLLG-IPVPVLIALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGILLAARLG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 249 STRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPIITRRM 328
Cdd:COG1172  240 SAQPNAGSGYELDAIAAVVIGGTSLTGGRGSVLGTLLGALILGVLNNGLNLLGVSSYWQQIVKGAIILLAVLLDRLRRRR 319


                 ...
gi 488971945 329 MQR 331
Cdd:COG1172  320 RAR 322
TM_PBP1_transp_AraH_like cd06579
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the ...
 61-321 3.29e-70

Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.


Pssm-ID: 119321 [Multi-domain]  Cd Length: 263  Bit Score: 219.20  E-value: 3.29e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  61 FTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMGFCAA-AGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITI 139
Cdd:cd06579    1 AAVLGILALGMTLVIITGGIDLSVGSVAALSAVVAALLLVnAGLPIPLAILAALAVGALIGLLNGLLVAYLRIPPFIVTL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 140 GTMSLYRGITYILLGDQALNHYPESFAWFGQGYVWGALSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGI 219
Cdd:cd06579   81 GTMFILRGLALLITGGRPISGLPPLFSFFLGGGLILGIPVPVLIALAVALVAWFLLRRTRFGRYLYAVGGNPEAARLSGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 220 NVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSL 299
Cdd:cd06579  161 NVRRVKILAYVLSGLLAGLAGILLAARLGSAQPTAGNGYELDAIAAVVLGGTSLTGGRGSVLGTLLGALLLGVLNNGLNL 240

                        250       260
                 ....*....|....*....|..
gi 488971945 300 LNVPGIVMSVIIGAMLIVVISL 321
Cdd:cd06579  241 LGVSSFWQQIVKGAILLLAVAL 262
araH PRK11285
L-arabinose transporter permease protein; Provisional
 13-333 5.24e-44

L-arabinose transporter permease protein; Provisional


Pssm-ID: 183076 [Multi-domain]  Cd Length: 333  Bit Score: 153.68  E-value: 5.24e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  13 APAAPSPLRRLLCWEGF-LLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALS 91
Cdd:PRK11285  14 AAPPKSRFSLWRIWDQYgMLVVFAVLFIACSLFVPNFASFINMKGLGLAISMIGMVACTMLFCLASGDFDLSVASVVAFA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  92 STVMGFCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWFGQG 171
Cdd:PRK11285  94 GVVTAVVINATESLWLGVAAGLLLGAAVGLVNGFVIARLKINALITTLATMQIVRGLAYIISDGKAVGISDERFFALGYA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 172 YVWGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTR 251
Cdd:PRK11285 174 NFFG-VPAPIWLTVACFVVFGFLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLQGLVSALAGVILASRMTSGQ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 252 PTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIvvisLPIITRRMMQR 331
Cdd:PRK11285 253 PMTSIGFELIVISACVLGGVSLKGGIAKISGVVAGVLILGTVENAMNLLNISPFYQYVVRGLILL----AAVLFDRYKQR 328


                 ..
gi 488971945 332 RR 333
Cdd:PRK11285 329 AK 330
XylH COG4214
ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism];
31-327 9.35e-42

ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443360 [Multi-domain]  Cd Length: 393  Bit Score: 149.50  E-value: 9.35e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  31 LAVTLAVFigNAVASPYFL---NIWNLSDATftfteKAIVVLPMAML--IIAREIDLSVASTMALSSTVMG-FCAAAGMD 104
Cdd:COG4214   31 LVVIWIVF--QILTGGTFLtprNLSNLLLQN-----SYIGILAIGMVlvILLGHIDLSVGSVSGFVGAVAAvLMVNWGLP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 105 TPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWFGQGYVWGALSFE---- 180
Cdd:COG4214  104 WWLAILAALLVGALIGAWQGFWVAYVGIPSFIVTLAGMLAFRGLTLLVLGGGTIAPFDPTFQAIGNGFLPDILGTLswvl 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 181 -----------------------------------------------------------FALFILLAAAFTFLLHKTNFG 201
Cdd:COG4214  184 gavavaayvalqlrsrrrrrryglpveplwlfvlklallavlilgavyllnsyrgipivVLILLVLVVVYTFVLTRTVFG 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 202 RRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLGGVNILGGSGSMP 281
Cdd:COG4214  264 RHIYAVGGNPEAARLSGINVRRVTFSVFVNMGVLAALAGIVFAARLNSATPSAGTGFELDAIAAAVIGGTSLFGGVGTVY 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 488971945 282 GVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPIITRR 327
Cdd:COG4214  344 GAVIGALVMGSLNNGMSLLGVDSDWQQIVKGLVLLLAVAFDVLSRR 389
PRK09699 PRK09699
D-allose ABC transporter permease;
29-321 5.07e-41

D-allose ABC transporter permease;


Pssm-ID: 182035 [Multi-domain]  Cd Length: 312  Bit Score: 145.30  E-value: 5.07e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  29 FLLAVTLAVFigNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMGFCAAAGMDTPLL 108
Cdd:PRK09699  16 FILAIIVAIF--GSLSPEYFLTTNNITQIFVQSSVTVLIGMGEFFAILVAGIDLSVGAILALSGMVTAKLMLAGVDPFLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 109 VVIGLGVGLLCG-LFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWFGQGYVWGaLSFEFALFILL 187
Cdd:PRK09699  94 ALIGGVLVGGALgAINGCLVNWTGLHPFIITLGTNAIFRGITLVISDANSVYGFSFDFVNFFAASVIG-IPVPVIFSLIV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 188 AAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAV 267
Cdd:PRK09699 173 ALILWFLTTRMRLGRNIYALGGNKNSAFYSGIDVKFHILVVFIISGVCAGLAGVVSTARLGAAEPLAGMGFETYAIASAI 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488971945 268 LGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISL 321
Cdd:PRK09699 253 IGGTSFFGGKGRIFSVVIGGLIIGTINNGLNILQVQTYYQLVVMGGLIIAAVAL 306
rbsC PRK09512
ribose ABC transporter permease protein; Reviewed
 45-317 7.53e-37

ribose ABC transporter permease protein; Reviewed


Pssm-ID: 181922 [Multi-domain]  Cd Length: 320  Bit Score: 134.46  E-value: 7.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  45 SPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMGfcAAAGMDTPLLVVIGLGVGLLCG--LF 122
Cdd:PRK09512  36 SPNFFTVNNLFNILQQTSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVAA--SIVGIEVNALVAVPAALALGAAigAV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 123 NGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALN----HYPESFAWFGQGYVWGALSFEFALFILLAAAFtFLLHKT 198
Cdd:PRK09512 114 TGVIVAKGKVQAFIATLVMMLLLRGVTMVYTDGSPINtgftDNADLFGWFGIGRPLGIPTPVWIMAIVFLAAW-YMLHHT 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 199 NFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLGGVNILGGSG 278
Cdd:PRK09512 193 RLGRYIYALGGNEAATRLSGINVNKVKIIVYALCGLLAALAGIIEVARLSSAQPTAGTGYELDAIAAVVLGGTSLAGGKG 272

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 488971945 279 SMPGVIIAAFLMGLVTFGLSLLNVPG----IVMSVIIGAMLIV 317
Cdd:PRK09512 273 RIVGTLIGALILGFLNNGLNLLGVSSyyqmIVKAVVILLAVLV 315
PRK15038 PRK15038
autoinducer 2 ABC transporter permease LsrD;
20-319 6.44e-35

autoinducer 2 ABC transporter permease LsrD;


Pssm-ID: 184998  Cd Length: 330  Bit Score: 129.95  E-value: 6.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  20 LRRLLCWEGFLLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMGFCA 99
Cdd:PRK15038   1 MRRRYGWELALAALLVIEILAFGLINPRMLDINVLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIALGVLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 100 AAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYIL------LGDQALNHYPESFAWFGQGYV 173
Cdd:PRK15038  81 QSGVPMPLAILLTLLLGALCGLINAGLIIYTGVNPLVITLGTLYLFGGSALLLsgmagaTGYEGIGGFPMAFTDFANLDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 174 WGaLSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPT 253
Cdd:PRK15038 161 LG-LPVPLIIFLICLLVFWLLMHRTHAGRNVFLIGQSPRVALYSAIPVNRTLCALYAMTGLASAIAAVLLVSYFGSARSD 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488971945 254 LAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVI 319
Cdd:PRK15038 240 LGASFLMPAITAVVLGGANIYGGSGSIIGTALAVLLVGYLQQGLQMAGVPNQISSALSGALLIVVV 305
PRK15432 PRK15432
autoinducer 2 ABC transporter permease LsrC; Provisional
 30-331 1.87e-32

autoinducer 2 ABC transporter permease LsrC; Provisional


Pssm-ID: 185330 [Multi-domain]  Cd Length: 344  Bit Score: 123.30  E-value: 1.87e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  30 LLAVTLAVFIGNAVASPYFlniwNLSDATFTFTEKAIVVL---PMAMLIIAREIDLSVASTMALSSTVMGFCAAAGMDTP 106
Cdd:PRK15432  14 LLAIVLLFVLLGFLDRQYL----SLQTLTMVFSSAQILILlaiGATLVMLTRNIDVSVGSITGLCAVLVGMLLNAGYSLP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 107 LLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQALNHYPESFAWFGQGYVWGALSFEFALFIL 186
Cdd:PRK15432  90 VACLATLLLGLLAGFFNGVLVAWLRIPAIVATLGTLGLYRGIMLLWTGGKWIEGLPAELKQLSAPILLGISPIGWLTLIL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 187 LAAAFtFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMA 266
Cdd:PRK15432 170 ILAMA-WLLAKTAFGRSFYATGDNLQGARQLGVRTEAIRIVAFSLNGCMAALAGIVFASQIGFIPNQTGTGLEMKAIAAC 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488971945 267 VLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPIITRRMMQR 331
Cdd:PRK15432 249 VLGGISLLGGSGTIIGAVLGAYFLTQIDSVLVLLRIPAWWNDFIAGLVLLGVLVFDGRLRCALER 313
mglC PRK09478
galactose/methyl galactoside ABC transporter permease MglC;
27-324 2.68e-28

galactose/methyl galactoside ABC transporter permease MglC;


Pssm-ID: 181892 [Multi-domain]  Cd Length: 336  Bit Score: 112.09  E-value: 2.68e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  27 EGFLLAVTLAVFIGNAVASPYFLNIWNLSDATFTFTEKAIVVLPMAMLIIAREIDLSVASTMALSSTVMG---------- 96
Cdd:PRK09478  15 EGGIYVVLLVLLAIIIIQDPTFLSLLNLSNILTQSSVRIIIALGVAGLIVTQGTDLSAGRQVGLAAVVAAtllqsmdnan 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  97 --FCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGIT---YILLGDQALNHYPESFAWFGQG 171
Cdd:PRK09478  95 kvFPELATMPIALVILIVCAIGAVIGLINGLIIAYLNVTPFIATLGTMIIVYGINslyYDFVGASPISGFDSGFSTFAQG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 172 YV-WGALSFEFALFILLAAAFT--FLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLG 248
Cdd:PRK09478 175 FVaLGSFRLSYITFYALIAVAFvwVLWNKTRFGKNIFAIGGNPEAAKVSGVNVPLNLLMIYALSGVFYAFGGMLEAGRIG 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488971945 249 STRPTLAMGWELAVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIVMSVIIGAMLIVVISLPII 324
Cdd:PRK09478 255 SATNNLGFMYELDAIAACVVGGVSFSGGVGTVIGVVTGVIIFTVINYGLTYIGVNPYWQYIIKGAIIIFAVALDSL 330
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
 65-318 1.31e-26

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 105.80  E-value: 1.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945   65 AIVVLPMAMLI-IAREIDLSVASTMALSS-TVMGFCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFNLSSIVITIGTM 142
Cdd:pfam02653  13 AIAALGLTLIYgIAGVINLGHGGFMMLGAyVAAMLLNLLGPGLWLALPVGILVGAAVGLLIGILTLRLKINEVIITLLLN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  143 SLYRGITYIL----LGDQALNHYPESFAWFGQGYVWGALSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSG 218
Cdd:pfam02653  93 LAALGLALFLvtgiLGGEGGTSGITGPSGFPGAFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRAVGENEEAARAAG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  219 INVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLA-MGWELAVVTMAVLGGVnilggsGSMPGVIIAAFLMGLV-TFG 296
Cdd:pfam02653 173 INVKKLKLLTFVISGALAGLAGALLALYTGVVPPSNFgVGLGLDAIAAVVLGGA------GSPIGVVIGSLIIGLVqSLG 246

                         250       260
                  ....*....|....*....|..
gi 488971945  297 LSLLNVPGIVMSVIIGAMLIVV 318
Cdd:pfam02653 247 LGALGSPPELSLLVLGALLILV 268
PRK11618 PRK11618
inner membrane ABC transporter permease protein YjfF; Provisional
 31-321 1.20e-17

inner membrane ABC transporter permease protein YjfF; Provisional


Pssm-ID: 183235 [Multi-domain]  Cd Length: 317  Bit Score: 81.92  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  31 LAVTLAVFI-GNAVASPYFLNIWNLSDATFTFTEKA---IVVLPMAMLIIAREIDLSVASTMALSSTVMGFCAAAGMDTP 106
Cdd:PRK11618   8 LMITIGVFVlGYLFCLVQFPGFASTRVICNLLTDNAflgIVAVGMTFVILSGGIDLSVGSVIAFTGVFLAKLIGDYGWSP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 107 LLVV-IGLGVGLLCGLFNGLLVTRFNLSSIVITIGTMSLYRGITYILLGDQ-ALNH----YPESFAWFGQGYvwGALSFE 180
Cdd:PRK11618  88 LLAFpLVLVMGAAFGAFMGALIHYLKLPAFIVTLAGMFLARGVSFLVSEESiPINHpfydTLSSLAWKLPGG--GRLSAM 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 181 FALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWEL 260
Cdd:PRK11618 166 ALIMLAVVAIGIFLAHRTRFGNNVYAIGGNATSANLMGIPVRRTTIRIYMLSGFLATLAGIVFSLYTSAGYALAAVGVEL 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488971945 261 AVVTMAVLGGVNILGGSGSMPGVIIAAFLMGLVTfglSLLNVPGIVMS----VIIGAMLIVVISL 321
Cdd:PRK11618 246 DAIAAVVIGGTLLTGGVGTVLGTLFGVLIQGLIQ---TYITFDGTLSSwwtkIVIGILLFVFIAL 307
LivH COG0559
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ...
 126-319 1.60e-13

Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440325 [Multi-domain]  Cd Length: 290  Bit Score: 69.71  E-value: 1.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 126 LVTRFNLSSIVITIGTMSLYRGITYILLGDQALNhYPesfAWFGQGYVWGALSFE------FALFILLAAAFTFLLHKTN 199
Cdd:COG0559   87 LRGAPPLALLLATIGLSLVLQGLVLLIFGADPRS-FP---ALLSGSVELGGVSIPayrlfiIVVALVLLAALWLFLRRTR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 200 FGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGstrPTLAMGWELAVVTMAVLggvnILGGSGS 279
Cdd:COG0559  163 LGLAMRAVAQNREAARLMGINVDRVIALTFALGAALAGLAGVLLAPIYS---VSPTMGFLLGLKAFAAV----VLGGLGS 235

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 488971945 280 MPGVIIAAFLMGLVTfGLSLLNVPGIVMSVIIGAMLIVVI 319
Cdd:COG0559  236 IPGAVVGGLLLGLAE-SLGAAYLPSGYKDVVAFVLLILVL 274
TM_PBP1_LivH_like cd06582
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ...
 132-319 3.92e-13

Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119324 [Multi-domain]  Cd Length: 272  Bit Score: 68.61  E-value: 3.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 132 LSSIVITIGTMSLYRGITYILLGDQALNHYP---ESFAWFGQGYVWGALsFEFALFILLAAAFTFLLHKTNFGRRTYAIG 208
Cdd:cd06582   83 LTLLITFGGLLILLQGLLLIFGGDPRVPPPPllsGSVELGGVTIPPYRL-FIIAVALVLLAALYLFLRRTRLGRAIRAVA 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 209 NNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGStrpTLAMGWELAVVTMAVLggvnILGGSGSMPGVIIAAF 288
Cdd:cd06582  162 QNPEAARLLGINVRRVFALTFALGAALAGLAGVLLAPITGV---SPTMGLLLLLKAFAAV----VLGGLGSIPGAVVGGL 234

                        170       180       190
                 ....*....|....*....|....*....|.
gi 488971945 289 LMGLVTFGLSLLNVPGIVMSVIIGAMLIVVI 319
Cdd:cd06582  235 LLGLAESLAAAYLSSGYKDAVAFVLLILVLL 265
NupP COG4603
ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and ...
 181-333 1.65e-12

ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and metabolism];


Pssm-ID: 443653 [Multi-domain]  Cd Length: 356  Bit Score: 67.45  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 181 FALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLA-AVLLTSRLGSTRPTLAMGWE 259
Cdd:COG4603  200 LLIALLAAVLVWVLLNRTTLGYELRAVGLNPRAARYAGINVKRLIVLAMLISGALAGLAgAVEVLGVQGRLTPGFSPGYG 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488971945 260 LAVVTMAVLGGVNILggsgsmpGVIIAAFLMG-LVTFGLSL---LNVPGIVMSVIIGAMLIVVISLPIITRRMMQRRR 333
Cdd:COG4603  280 FTGIAVALLGRNNPL-------GIILAALLFGaLYVGGDAMqraLGVPSEIVDVIQGLIILFVLAADFLIRYRLRRRR 350
TM_PBP1_LivM_like cd06581
Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two ...
 162-319 1.83e-11

Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119323 [Multi-domain]  Cd Length: 268  Bit Score: 63.62  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 162 PESFAWFGQGYVWGALSFEFALFILLAA-AFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAA 240
Cdd:cd06581  108 IPPPLLGGLLLSSPLAFYYLVLAVLLLVlLLLRRLVRSPFGRALRAIRENEVAAEALGINVTRYKLLAFALSAALAGLAG 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488971945 241 VLLTSRLGSTRPTlAMGWELAVVTMAVLggvnILGGSGSMPGVIIAAFLMGLVTFGLSllNVPGIVMSVIIGAMLIVVI 319
Cdd:cd06581  188 ALYAHYLGFVSPE-SFGFALSIELLLMV----VLGGLGSLLGPVLGAALLVLLPELLR--SLGPGLRLLVFGLLLILVV 259
LivM COG4177
ABC-type branched-chain amino acid transport system, permease component [Amino acid transport ...
 165-319 1.26e-10

ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443336 [Multi-domain]  Cd Length: 285  Bit Score: 61.25  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 165 FAWFGQGYVWGALSFEFALFILLAA-AFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLL 243
Cdd:COG4177  121 PTLFGLDLGSPLAFYYLVLALLVLVlLLLRRLVRSRFGRALRAIRENEIAAEALGINVTRYKLLAFVLSAALAGLAGALY 200

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488971945 244 TSRLGSTRPTlAMGWELAVVTMAVLggvnILGGSGSMPGVIIAAFLMGLVTFGLSllNVPGIVMsVIIGAMLIVVI 319
Cdd:COG4177  201 AHYVGFVSPE-SFSFLLSIEILLMV----VLGGLGSLLGPVLGAVLLVLLPELLR--SLPEYRL-LIFGLLLILVV 268
TM_PBP1_branched-chain-AA_like cd06574
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette ...
 76-319 2.38e-10

Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.


Pssm-ID: 119320 [Multi-domain]  Cd Length: 266  Bit Score: 60.37  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945  76 IAREIDLSVASTMALSSTVMGFCAAAGMDTPLLVVIGLGVGLLCGLFNGLLVTRFN----LSSIVITIGTMSL---YRGI 148
Cdd:cd06574   17 ILGFPDLTVDGSFPLGAAVAAILIVAGYNPWLALIAAILAGAAAGLVTGFLHTRLKinglLAGILIMIGLYSInlrIMGG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 149 TYILLGDQALNHYPESFAWFGQGYVWGALSfefALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVL 228
Cdd:cd06574   97 PNIPLGTRDTLLGLLLLFGISGTLSIPVVL---LLIVLLVLFLVIWFLRTKLGLAMRATGDNPDMARSLGINVDRTRILG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 229 FALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLGG--VNILGGSGSMPGVIIAAFLMGLVTFGLSLLNVPGIV 306
Cdd:cd06574  174 LVISNALAALGGALYAQYQGFADVNMGIGTGVIGLAAVIIGGaiVGRRTIKASILGVIIGAILYRIALALALGSGLIPSD 253

                        250
                 ....*....|...
gi 488971945 307 MSVIIGAMLIVVI 319
Cdd:cd06574  254 LKLITAGVIVLVL 266
TM_PBP1_transp_TpRbsC_like cd06580
Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. ...
 173-318 9.30e-10

Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters, which are mainly involved in the uptake of branched-chain amino acids (AAs) or in the uptake of monosaccharides including ribose, galactose, and arabinose, and which generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction.


Pssm-ID: 119322 [Multi-domain]  Cd Length: 234  Bit Score: 57.83  E-value: 9.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 173 VWGALSFEFALFILLAAAFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLA-AVLLTSRLGSTR 251
Cdd:cd06580   90 ALGLTSYLLLLALLLVILVWLLLYRTRFGLRLRAVGENPRAARYAGINVKRVRLLAMLISGALAGLAgAYLVLGVQGRFT 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488971945 252 PTLAMGWELAVVTMAVLGGVNILggsgsmpGVIIAAFLMGLVTFGLSLLN----VPGIVMSVIIGAMLIVV 318
Cdd:cd06580  170 EGMSAGYGFIAIAVALLGRWNPL-------GILLAALLFGALEAGGIALQrsggVPSELVQVLPGIIVLFV 233
PRK10740 PRK10740
high-affinity branched-chain amino acid ABC transporter permease LivH;
190-319 2.87e-03

high-affinity branched-chain amino acid ABC transporter permease LivH;


Pssm-ID: 182689 [Multi-domain]  Cd Length: 308  Bit Score: 39.14  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488971945 190 AFTFLLHKTNFGRRTYAIGNNPTGAWFSGINVKRHNLVLFALVGLMAGLAAVLLTSRLGSTRPTLAMGWELAVVTMAVLG 269
Cdd:PRK10740 170 ALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLG 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488971945 270 GVnilggsGSMPGVIIAAFLMGlVTFGLSLLNVPGIVMSVIIGAMLIVVI 319
Cdd:PRK10740 250 GI------GSIPGAMIGGLILG-IAEALSSAYLSTEYKDVVSFALLILVL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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