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Conserved domains on  [gi|488972493|ref|WP_002883411|]
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MULTISPECIES: homoserine/homoserine lactone efflux protein [Klebsiella]

Protein Classification

homoserine/homoserine lactone efflux protein( domain architecture ID 10013551)

homoserine/homoserine lactone efflux protein exports homoserine and homoserine lactone

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rhtB PRK10520
homoserine/homoserine lactone efflux protein; Provisional
1-205 6.63e-135

homoserine/homoserine lactone efflux protein; Provisional


:

Pssm-ID: 182514  Cd Length: 205  Bit Score: 376.36  E-value: 6.63e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:PRK10520   1 MTLEWWLAYLLTSIILSLSPGSGAINTMSTSISHGYRGAVASIAGLQTGLAIHIVLVGVGLGALFSQSLLAFEVLKWAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  81 AYLIWLGIQQWRAAGAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVTTIVVDII 160
Cdd:PRK10520  81 AYLIWLGIQQWRAAGAIDLHTLASTQSRRRLFKRAVFVNLTNPKSIVFLAALFPQFIMPQQPQLMQYLVLGVTTVVVDII 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKALNKVFGSLFMLVGALLASARH 205
Cdd:PRK10520 161 VMIGYATLAQRIARWIKGPKQMKALNKIFGSLFMLVGALLASARH 205
 
Name Accession Description Interval E-value
rhtB PRK10520
homoserine/homoserine lactone efflux protein; Provisional
1-205 6.63e-135

homoserine/homoserine lactone efflux protein; Provisional


Pssm-ID: 182514  Cd Length: 205  Bit Score: 376.36  E-value: 6.63e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:PRK10520   1 MTLEWWLAYLLTSIILSLSPGSGAINTMSTSISHGYRGAVASIAGLQTGLAIHIVLVGVGLGALFSQSLLAFEVLKWAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  81 AYLIWLGIQQWRAAGAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVTTIVVDII 160
Cdd:PRK10520  81 AYLIWLGIQQWRAAGAIDLHTLASTQSRRRLFKRAVFVNLTNPKSIVFLAALFPQFIMPQQPQLMQYLVLGVTTVVVDII 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKALNKVFGSLFMLVGALLASARH 205
Cdd:PRK10520 161 VMIGYATLAQRIARWIKGPKQMKALNKIFGSLFMLVGALLASARH 205
2A76 TIGR00949
The Resistance to Homoserine/Threonine (RhtB) Family protein; [Transport and binding proteins, ...
19-200 2.11e-58

The Resistance to Homoserine/Threonine (RhtB) Family protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273358  Cd Length: 185  Bit Score: 181.76  E-value: 2.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   19 SPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQWRA----A 94
Cdd:TIGR00949   1 SPGPNFFVVMQTSLSSGRRAGVLTILGIALGDAIWIVLSLLGLAVLISKSVILFTVIKWLGGAYLIYLGIKMLRKkskkQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   95 GAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPqVMQYLVLGVTTIVVDIIVMIGYATLAQRISA 174
Cdd:TIGR00949  81 SPAAQVELAEQTTWKKSFRRGLLTNLSNPKAVLFFISIFSQFINPNTP-TWQLIVLGLTIIVETILWFYVLSLIFSRPAV 159
                         170       180
                  ....*....|....*....|....*.
gi 488972493  175 WIKGPKQMKALNKVFGSLFMLVGALL 200
Cdd:TIGR00949 160 RRKYSKQQKWIDGITGALFVGFGIRL 185
RhtB COG1280
Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];
1-205 1.69e-52

Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];


Pssm-ID: 440891  Cd Length: 205  Bit Score: 167.32  E-value: 1.69e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:COG1280    1 MSLELLLAFLLAALVLALTPGPDNLLVLSRGLRRGRRAGLAAALGIALGDLVHILLAALGLAALLAASPLLFTVLKLAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  81 AYLIWLGIQQWRAAGAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVTTIVVDII 160
Cdd:COG1280   81 AYLLYLGWKLLRSAGRPLAAEAAAAASARRLFRQGFLLNLLNPKAILFFLAFLPQFVDPGAPLLLQLLLLGATFLLVSLL 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKALNKVFGSLFMLVGALLASARH 205
Cdd:COG1280  161 WLLLYALLASRLRRRLRSPRALRWLNRVAGLLLIGFGLRLALSRR 205
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
14-201 1.17e-44

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 147.05  E-value: 1.17e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   14 IILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQWRA 93
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISRGFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   94 AGAIDLNTLAKAQT-RGKLFQRAVFVNLTNPKSIVFLAALFPQFILP-HQPQVMQYLVLGVTTIVVDIIVMIGYATLAQR 171
Cdd:pfam01810  81 AKSPKNESLSSSEAsLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKnQQYGDAGRLIFAAGIVVASLIWFSLLAFLASR 160
                         170       180       190
                  ....*....|....*....|....*....|
gi 488972493  172 ISAWIKGPKQMKALNKVFGSLFMLVGALLA 201
Cdd:pfam01810 161 LARRLSTPKVRRIINVIAGALFIGFGVFLL 190
 
Name Accession Description Interval E-value
rhtB PRK10520
homoserine/homoserine lactone efflux protein; Provisional
1-205 6.63e-135

homoserine/homoserine lactone efflux protein; Provisional


Pssm-ID: 182514  Cd Length: 205  Bit Score: 376.36  E-value: 6.63e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:PRK10520   1 MTLEWWLAYLLTSIILSLSPGSGAINTMSTSISHGYRGAVASIAGLQTGLAIHIVLVGVGLGALFSQSLLAFEVLKWAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  81 AYLIWLGIQQWRAAGAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVTTIVVDII 160
Cdd:PRK10520  81 AYLIWLGIQQWRAAGAIDLHTLASTQSRRRLFKRAVFVNLTNPKSIVFLAALFPQFIMPQQPQLMQYLVLGVTTVVVDII 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKALNKVFGSLFMLVGALLASARH 205
Cdd:PRK10520 161 VMIGYATLAQRIARWIKGPKQMKALNKIFGSLFMLVGALLASARH 205
2A76 TIGR00949
The Resistance to Homoserine/Threonine (RhtB) Family protein; [Transport and binding proteins, ...
19-200 2.11e-58

The Resistance to Homoserine/Threonine (RhtB) Family protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273358  Cd Length: 185  Bit Score: 181.76  E-value: 2.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   19 SPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQWRA----A 94
Cdd:TIGR00949   1 SPGPNFFVVMQTSLSSGRRAGVLTILGIALGDAIWIVLSLLGLAVLISKSVILFTVIKWLGGAYLIYLGIKMLRKkskkQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   95 GAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPqVMQYLVLGVTTIVVDIIVMIGYATLAQRISA 174
Cdd:TIGR00949  81 SPAAQVELAEQTTWKKSFRRGLLTNLSNPKAVLFFISIFSQFINPNTP-TWQLIVLGLTIIVETILWFYVLSLIFSRPAV 159
                         170       180
                  ....*....|....*....|....*.
gi 488972493  175 WIKGPKQMKALNKVFGSLFMLVGALL 200
Cdd:TIGR00949 160 RRKYSKQQKWIDGITGALFVGFGIRL 185
RhtB COG1280
Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];
1-205 1.69e-52

Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];


Pssm-ID: 440891  Cd Length: 205  Bit Score: 167.32  E-value: 1.69e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:COG1280    1 MSLELLLAFLLAALVLALTPGPDNLLVLSRGLRRGRRAGLAAALGIALGDLVHILLAALGLAALLAASPLLFTVLKLAGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  81 AYLIWLGIQQWRAAGAIDLNTLAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVTTIVVDII 160
Cdd:COG1280   81 AYLLYLGWKLLRSAGRPLAAEAAAAASARRLFRQGFLLNLLNPKAILFFLAFLPQFVDPGAPLLLQLLLLGATFLLVSLL 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKALNKVFGSLFMLVGALLASARH 205
Cdd:COG1280  161 WLLLYALLASRLRRRLRSPRALRWLNRVAGLLLIGFGLRLALSRR 205
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
14-201 1.17e-44

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 147.05  E-value: 1.17e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   14 IILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQWRA 93
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISRGFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   94 AGAIDLNTLAKAQT-RGKLFQRAVFVNLTNPKSIVFLAALFPQFILP-HQPQVMQYLVLGVTTIVVDIIVMIGYATLAQR 171
Cdd:pfam01810  81 AKSPKNESLSSSEAsLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKnQQYGDAGRLIFAAGIVVASLIWFSLLAFLASR 160
                         170       180       190
                  ....*....|....*....|....*....|
gi 488972493  172 ISAWIKGPKQMKALNKVFGSLFMLVGALLA 201
Cdd:pfam01810 161 LARRLSTPKVRRIINVIAGALFIGFGVFLL 190
PRK10958 PRK10958
leucine export protein LeuE; Provisional
9-203 3.30e-19

leucine export protein LeuE; Provisional


Pssm-ID: 236807  Cd Length: 212  Bit Score: 81.46  E-value: 3.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   9 YLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLG- 87
Cdd:PRK10958  13 YLVGAIFIVLLPGPNSLYVLSTAARRGVKAGYRAACGVFIGDAVLMFLAAAGVASLLKATPLLFNVVKYLGAAYLLYLGv 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  88 ------IQQWRAAGAidlntlAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQ-VMQYLVLGVTTIVVDII 160
Cdd:PRK10958  93 kmlraaLRRWRRRAA------SAAPPYGAPFRRALILSLTNPKAILFFVSFFVQFVDPNYAHpALSFLILATILQLVSFC 166
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488972493 161 VMIGYATLAQRISAWIKGPKQMKAL-NKVFGSLFMLVGALLASA 203
Cdd:PRK10958 167 YLSFLIFSGARLAAYFRRRKKLAAGgNSLVGLLFVGFAAKLATA 210
ArgO COG1279
Arginine exporter protein ArgO [Amino acid transport and metabolism];
23-201 1.32e-05

Arginine exporter protein ArgO [Amino acid transport and metabolism];


Pssm-ID: 440890  Cd Length: 204  Bit Score: 44.01  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  23 GAINT--MTTSINHGYRGAAASIAGLQTGLAIhivLVGV-GLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQWRAA----G 95
Cdd:COG1279   20 GAQNAfvLRQGLRREHVLPVALICALSDALLI---ALGVfGVGALLAASPWLLTVLRWGGAAFLLWYGLRALRRAlrggA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  96 AIDLNTlAKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILPHQPQVMQYLVLGVttIVVDIIVMIGYATLAQRISAW 175
Cdd:COG1279   97 ALDAAE-GAALSLRKAILTALAVTLLNPHVYLDTVVLLGSIAAQYGGDERWAFALGA--ILASFLWFFGLGYGARLLAPL 173
                        170       180
                 ....*....|....*....|....*.
gi 488972493 176 IKGPKQMKALNKVFGSLFMLVGALLA 201
Cdd:COG1279  174 FARPRAWRVLDLLIGLVMWAIALKLL 199
PRK10323 PRK10323
cysteine/O-acetylserine transporter;
1-139 2.84e-05

cysteine/O-acetylserine transporter;


Pssm-ID: 182377  Cd Length: 195  Bit Score: 43.32  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493   1 MTIEWWFAYLLTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGA 80
Cdd:PRK10323   1 MTPTLLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGA 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488972493  81 AYLIWLGIQQWRAAGAIDlntlaKAQTRGKLFQRAVFVNLTNPKSIVFLAALFPQFILP 139
Cdd:PRK10323  81 AYIVWLAWKIATSPTKED-----GLQAKPISFWASFALQFVNVKIILYGITALSTFVLP 134
PRK10229 PRK10229
threonine efflux system; Provisional
11-137 4.06e-05

threonine efflux system; Provisional


Pssm-ID: 236665  Cd Length: 206  Bit Score: 42.77  E-value: 4.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488972493  11 LTSIILSLSPGSGAINTMTTSINHGYRGAAASIAGLQTGLAIHIVLVGVGLGTLFSRSVLAFEVLKWAGAAYLIWLGIQQ 90
Cdd:PRK10229  10 MVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGVALLGLHLILEKMAWLHTIIMVGGGLYLCWMGYQM 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488972493  91 WRAAGAIDLNTLAKAQ----TRGKLFQRAVFVNLTNPKSIVFLAALFPQFI 137
Cdd:PRK10229  90 LRGALKKEDVAAEEPQvelaKSGRSFLKGLLTNLSNPKAIIYFGSVFSLFV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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