NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488976002|ref|WP_002886889|]
View 

MULTISPECIES: GNAT family N-acetyltransferase [Klebsiella]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-146 6.36e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.31  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   7 VRSTDSPHFAMLDALYARAFPwhEQRESEAKRQALSHPRYALE-AWFDEGVFVGLSGCWQF-----AGYGYIEHLAIDDT 80
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG--PGREAELVDRLREDPAAGLSlVAEDDGEIVGHVALSPVdidgeGPALLLGPLAVDPE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488976002  81 LRSRGYGKQLLAQILTRAplTILEIDPLTTAIAHKRLRFYQSMGFHANPWAHHHPSYHQGIADHEL 146
Cdd:COG3153   79 YRGQGIGRALMRAALEAA--RERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-146 6.36e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.31  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   7 VRSTDSPHFAMLDALYARAFPwhEQRESEAKRQALSHPRYALE-AWFDEGVFVGLSGCWQF-----AGYGYIEHLAIDDT 80
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG--PGREAELVDRLREDPAAGLSlVAEDDGEIVGHVALSPVdidgeGPALLLGPLAVDPE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488976002  81 LRSRGYGKQLLAQILTRAplTILEIDPLTTAIAHKRLRFYQSMGFHANPWAHHHPSYHQGIADHEL 146
Cdd:COG3153   79 YRGQGIGRALMRAALEAA--RERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 15-125 1.77e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 47.51  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   15 FAMLDALYARAFPW-HEQRESEAKRQALSHPRYALEAWFDEGVFVG---LSGCWQFAGYGYIEHLAIDDTLRSRGYGKQL 90
Cdd:pfam00583   1 LEALYELLSEEFPEpWPDEPLDLLEDWDEDASEGFFVAEEDGELVGfasLSIIDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 488976002   91 LAQILTRAPLTILEIDPLTTAIAHKR-LRFYQSMGF 125
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADNLAaIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-98 7.81e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 7.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 488976002  57 FVGLSGCWQFAGYGYIEHLAIDDTLRSRGYGKQLLAQILTRA 98
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-146 6.36e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 49.31  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   7 VRSTDSPHFAMLDALYARAFPwhEQRESEAKRQALSHPRYALE-AWFDEGVFVGLSGCWQF-----AGYGYIEHLAIDDT 80
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFG--PGREAELVDRLREDPAAGLSlVAEDDGEIVGHVALSPVdidgeGPALLLGPLAVDPE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488976002  81 LRSRGYGKQLLAQILTRAplTILEIDPLTTAIAHKRLRFYQSMGFHANPWAHHHPSYHQGIADHEL 146
Cdd:COG3153   79 YRGQGIGRALMRAALEAA--RERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 15-125 1.77e-07

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 47.51  E-value: 1.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   15 FAMLDALYARAFPW-HEQRESEAKRQALSHPRYALEAWFDEGVFVG---LSGCWQFAGYGYIEHLAIDDTLRSRGYGKQL 90
Cdd:pfam00583   1 LEALYELLSEEFPEpWPDEPLDLLEDWDEDASEGFFVAEEDGELVGfasLSIIDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 488976002   91 LAQILTRAPLTILEIDPLTTAIAHKR-LRFYQSMGF 125
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADNLAaIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-126 2.31e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.60  E-value: 2.31e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488976002   53 DEGVFVGLSGCWQFAGYGYIEH--LAIDDTLRSRGYGKQLLAQILTRAPLTILEIDPLTTaiAHKRLRFYQSMGFH 126
Cdd:pfam13508  10 DDGKIVGFAALLPLDDEGALAElrLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET--TNRAAAFYEKLGFE 83
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 28-127 2.52e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 44.57  E-value: 2.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002   28 WHEQRESEAKRQALSHPRYALEAWFDEGVFVGLSGcwqFAGYGYIEHLAIDDTLRSRGYGKQLLAQILTRAPLTILEIDP 107
Cdd:pfam13673  13 FYEFISPEALRERIDQGEYFFFVAFEGGQIVGVIA---LRDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSE 89

                          90       100
                  ....*....|....*....|....*
gi 488976002  108 LT-----TAIahkrlRFYQSMGFHA 127
Cdd:pfam13673  90 LTvnaspYAV-----PFYEKLGFRA 109
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 53-129 2.81e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 41.96  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488976002  53 DEGVFVGLSGCWQFAG-YGYIEHLAIDDTLRSRGYGKQLLAQIL--------TRAPLTILEIDPltTAIahkrlRFYQSM 123
Cdd:COG0454   41 DKGEPIGFAGLRRLDDkVLELKRLYVLPEYRGKGIGKALLEALLewarergcTALELDTLDGNP--AAI-----RFYERL 113


                 ....*.
gi 488976002 124 GFHANP 129
Cdd:COG0454  114 GFKEIE 119
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-126 5.09e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 40.41  E-value: 5.09e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488976002  68 GYGYIEHLAIDDTLRSRGYGKQLLAQILTRAP---LTILEidpLTTAIAHKR-LRFYQSMGFH 126
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARergARRLR---LEVREDNEAaIALYEKLGFE 71
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 57-126 5.91e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 40.75  E-value: 5.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488976002  57 FVGLSGCWqfAGYGYIEHLAIDDTLRSRGYGKQLLAQILTRAplTILEIDPL---TTAIAHkrlRFYQSMGFH 126
Cdd:COG1246   42 CAALHPLD--EDLAELRSLAVHPDYRGRGIGRRLLEALLAEA--RELGLKRLfllTTSAAI---HFYEKLGFE 107
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-98 7.81e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 7.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 488976002  57 FVGLSGCWQFAGYGYIEHLAIDDTLRSRGYGKQLLAQILTRA 98
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA 54
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
68-127 9.10e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 37.47  E-value: 9.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488976002  68 GYGYIEHLAIDDTLRSRGYGKQLLAQILTRA---PLTILEIDPLTTAIAhkrlrFYQSMGFHA 127
Cdd:COG2153   57 GEAKIGRVAVLPEYRGQGLGRALMEAAIEEArerGARRIVLSAQAHAVG-----FYEKLGFVP 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH