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Conserved domains on  [gi|488979540|ref|WP_002890380|]
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MULTISPECIES: PTS sugar transporter subunit IIA [Klebsiella]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10082877)

PTS sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system, a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates, such as mannitol and fructose, concomitantly with their translocation across the cell membrane

CATH:  3.40.930.10
Gene Ontology:  GO:1902495|GO:0009401|GO:0016310|GO:0016301|GO:0008643
PubMed:  11532441|10393270
SCOP:  4001876

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 5-142 1.16e-24

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


:

Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 91.85  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   5 FDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFgaAIVIDDGIAMPHARPEKgALQTGFSLVTTAT 84
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEG--STGIGNGIAIPHAKSEA-VKKPGIAVLRLKE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488979540  85 PISFGHDEFDPVSVVIAIAGADADSHIKMIQLIASLIES-DIVTFLQQENDVNSVLHFI 142
Cdd:cd00211   78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDeEFVEQLLNAQSKEEILALL 136
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 5-142 1.16e-24

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 91.85  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   5 FDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFgaAIVIDDGIAMPHARPEKgALQTGFSLVTTAT 84
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEG--STGIGNGIAIPHAKSEA-VKKPGIAVLRLKE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488979540  85 PISFGHDEFDPVSVVIAIAGADADSHIKMIQLIASLIES-DIVTFLQQENDVNSVLHFI 142
Cdd:cd00211   78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDeEFVEQLLNAQSKEEILALL 136
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
10-124 3.01e-24

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 91.57  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540  10 IALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFGAAIVIDDGIAMPHARPEKGALQTGFSLVTTATPISFG 89
Cdd:PRK10372  13 IRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVTLKKPLEFN 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488979540  90 HDEFDPVSVVIAIAGADADSHIKM-IQLIASLIESD 124
Cdd:PRK10372  93 HEDNDPVDILITMAAVDANTHQEVgIMQIVNLFEDE 128
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
4-143 4.05e-23

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 88.03  E-value: 4.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540    4 IFDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFGAAIVIddGIAMPHARPEkGALQTGFSLVTTA 83
Cdd:pfam00359   1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSE-AVKKPGIAVLTLK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979540   84 TPISFGHDEFDPVSVVIAIAGADADS-HIKMIQLIASLIES-DIVTFLQQENDVNSVLHFIQ 143
Cdd:pfam00359  78 EPVDFGSEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDeEFVEKLLKAKDPEEILEILK 139
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 4-144 3.70e-22

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 85.67  E-value: 3.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   4 IFDPSLIALKQNISRAEEAIELAGSLLARRQICS--AEYVNEMLTVYEDFGAAIviDDGIAMPHARPEkGALQTGFSLVT 81
Cdd:COG1762    6 LLTPELILLDLEASSKEEAIEELAELLAEKGYVLdkEEYLEALLEREELGSTGI--GPGIAIPHARPE-GVKKPGIAVAR 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488979540  82 TATPISFGHDEFDPVSVVIAIAG--ADADSHIKMIQLIASLI-ESDIVTFLQQENDVNSVLHFIQK 144
Cdd:COG1762   83 LKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLsDEEFREKLLNAKSPEEILELLKE 148
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 4-124 1.03e-04

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 39.57  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540    4 IFDPSLIALKQNISRAEEAIE-LAGSLLArrqicsAEYVNEMLTVYEDFGA--AIV---IDDGIAMPHArpeKGAL--QT 75
Cdd:TIGR00848   1 LLNKDLIFLDQQFTSKEDVIKfLANKLLE------NGYISDTEEFLEDLLKreEEGttgIGDGVAIPHA---KSAAvkQP 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488979540   76 GFSLVTTATPISFGHDEFDPVSVVIAIAGADA---DSHIKMIQLIASLIESD 124
Cdd:TIGR00848  72 FVAIARLVKGVDWQSLDGKPVKLIFLIAVPKDeagNTHLKALSQLARLLLND 123
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 5-142 1.16e-24

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 91.85  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   5 FDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFgaAIVIDDGIAMPHARPEKgALQTGFSLVTTAT 84
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEG--STGIGNGIAIPHAKSEA-VKKPGIAVLRLKE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488979540  85 PISFGHDEFDPVSVVIAIAGADADSHIKMIQLIASLIES-DIVTFLQQENDVNSVLHFI 142
Cdd:cd00211   78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDeEFVEQLLNAQSKEEILALL 136
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
10-124 3.01e-24

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 91.57  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540  10 IALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFGAAIVIDDGIAMPHARPEKGALQTGFSLVTTATPISFG 89
Cdd:PRK10372  13 IRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVTLKKPLEFN 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488979540  90 HDEFDPVSVVIAIAGADADSHIKM-IQLIASLIESD 124
Cdd:PRK10372  93 HEDNDPVDILITMAAVDANTHQEVgIMQIVNLFEDE 128
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
4-143 4.05e-23

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 88.03  E-value: 4.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540    4 IFDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEMLTVYEDFGAAIVIddGIAMPHARPEkGALQTGFSLVTTA 83
Cdd:pfam00359   1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSE-AVKKPGIAVLTLK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488979540   84 TPISFGHDEFDPVSVVIAIAGADADS-HIKMIQLIASLIES-DIVTFLQQENDVNSVLHFIQ 143
Cdd:pfam00359  78 EPVDFGSEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDeEFVEKLLKAKDPEEILEILK 139
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 4-144 3.70e-22

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 85.67  E-value: 3.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   4 IFDPSLIALKQNISRAEEAIELAGSLLARRQICS--AEYVNEMLTVYEDFGAAIviDDGIAMPHARPEkGALQTGFSLVT 81
Cdd:COG1762    6 LLTPELILLDLEASSKEEAIEELAELLAEKGYVLdkEEYLEALLEREELGSTGI--GPGIAIPHARPE-GVKKPGIAVAR 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488979540  82 TATPISFGHDEFDPVSVVIAIAG--ADADSHIKMIQLIASLI-ESDIVTFLQQENDVNSVLHFIQK 144
Cdd:COG1762   83 LKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLsDEEFREKLLNAKSPEEILELLKE 148
cmtB PRK09854
PTS mannitol transporter subunit IIA;
1-129 1.81e-18

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 76.18  E-value: 1.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   1 MEII--FDPSLIALKQNISRAEEAIELA-GSLLARRQIcSAEYVNEMLTVYEDFGAAIVIDDGIAMPHARPEKGALQTGF 77
Cdd:PRK09854   1 MRLSdyFPESSISVIHSAKDWQEAIDFSmVSLLDKNYI-SENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488979540  78 SLVTTATPISFGhDEFDPVSVVIAIAGADADSHIKMIQLIASLI-ESDIVTFL 129
Cdd:PRK09854  80 SLTLLEQGVYFP-GNDEPIKLLIGLSAADADSHIGAIQALSELLcEEEILEQL 131
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
 4-145 3.22e-12

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 59.79  E-value: 3.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   4 IFDPSLIALKQNISRAEEAIELAGSLLARRQICSAEYVNEML------TVYedfgaaivIDDGIAMPHARPE--KGALQT 75
Cdd:COG4668    3 ILTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLereaqvSTY--------LGNGIAIPHGTNEakDLVLKT 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488979540  76 GFSLVTTATPISFGHDEfdPVSVVIAIAGADaDSHIKMIQLIASLI-ESDIVTFLQQENDVNSVLHFIQKQ 145
Cdd:COG4668   75 GISVLQFPDGVDWGDGN--TVYLVIGIAAKS-DEHLEILRQLARVLsDEENVEKLAKATDAEEILALLTGE 142
PRK15083 PRK15083
PTS system mannitol-specific transporter subunit IICBA; Provisional
 10-139 8.43e-08

PTS system mannitol-specific transporter subunit IICBA; Provisional


Pssm-ID: 237905 [Multi-domain]  Cd Length: 639  Bit Score: 50.05  E-value: 8.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540  10 IALKQNISRAEEAIELAGSLLARRQICSAEYVNEML------TVYedfgaaivIDDGIAMPHARPE--KGALQTGFSLVT 81
Cdd:PRK15083 502 IFLGLKAATKEEAIRFAGEQLVKGGYVEPEYVDAMLdrekltSTY--------LGESIAVPHGTVEakDRVLKTGVVFCQ 573

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488979540  82 TATPISFGHDEFDPVSVVIAIAgADADSHIKMIQLIASLIESD-IVTFLQQENDVNSVL 139
Cdd:PRK15083 574 YPEGVRFGEEEDDIARLVIGIA-ARNNEHIQVITSLTNALDDEsVIERLAHTTSVDEVL 631
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 4-124 1.03e-04

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 39.57  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540    4 IFDPSLIALKQNISRAEEAIE-LAGSLLArrqicsAEYVNEMLTVYEDFGA--AIV---IDDGIAMPHArpeKGAL--QT 75
Cdd:TIGR00848   1 LLNKDLIFLDQQFTSKEDVIKfLANKLLE------NGYISDTEEFLEDLLKreEEGttgIGDGVAIPHA---KSAAvkQP 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488979540   76 GFSLVTTATPISFGHDEFDPVSVVIAIAGADA---DSHIKMIQLIASLIESD 124
Cdd:TIGR00848  72 FVAIARLVKGVDWQSLDGKPVKLIFLIAVPKDeagNTHLKALSQLARLLLND 123
nitro_reg_IIA TIGR01419
PTS IIA-like nitrogen-regulatory protein PtsN; This model describes a full-length protein of ...
 22-118 2.13e-03

PTS IIA-like nitrogen-regulatory protein PtsN; This model describes a full-length protein of about 160 residues closely related to the fructose-specific phosphotransferase (PTS) system IIA component. It is a regulatory protein found only in species with a phosphoenolpyruvate-protein phosphotransferase (enzyme I of PTS systems) and an HPr-like phosphocarrier protein, but not all species have a IIC-like permease. Members of this family are found in Proteobacteria, Chlamydia, and the spirochete Treponema pallidum. [Signal transduction, PTS]


Pssm-ID: 162350 [Multi-domain]  Cd Length: 145  Bit Score: 36.23  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488979540   22 AIELAGSLLARRQICSAEYVNEMLTVYEDFGAAIViDDGIAMPHARPEKGALQTGfSLVTTATPISFGHDEFDPVSVVIA 101
Cdd:TIGR01419  23 LLEIISLLAARELSLPEQDVFECLLAREKLGSTGV-GNGIAIPHGRLSGLKQPVG-VFIRLDAPVDFDALDGKPVDLLFA 100

                          90       100
                  ....*....|....*....|
gi 488979540  102 I---AGADADsHIKMIQLIA 118
Cdd:TIGR01419 101 LlvpENATAE-HLEALSRIA 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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