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Conserved domains on  [gi|488984250|ref|WP_002895043|]
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MULTISPECIES: succinate--CoA ligase subunit alpha [Enterobacteriaceae]

Protein Classification

succinate--CoA ligase subunit alpha( domain architecture ID 11414657)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

CATH:  3.40.50.261|3.40.50.720
EC:  6.2.1.5
Gene Ontology:  GO:0000166|GO:0004775|GO:0009361|GO:0006099|GO:0004776
SCOP:  4000071|4000014

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-289 0e+00

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 551.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   2 SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDS 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  82 ILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYEA 161
Cdd:COG0074   81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 162 VKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPK 241
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488984250 242 GKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:COG0074  241 GKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-289 0e+00

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 551.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   2 SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDS 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  82 ILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYEA 161
Cdd:COG0074   81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 162 VKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPK 241
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488984250 242 GKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:COG0074  241 GKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-289 0e+00

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 549.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   1 MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKD 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  81 SILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYE 160
Cdd:PRK05678  81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 161 AVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAP 240
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488984250 241 KGKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:PRK05678 241 PGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLK 289
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 0e+00

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 499.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250    3 VLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDSI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   83 LEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYEAV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  163 KQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPKG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 488984250  243 KRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAII 288
Cdd:TIGR01019 241 KRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-100 3.68e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 117.23  E-value: 3.68e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250     4 LINKDTKVICQGFTGSQGTFHSEQAIA---YGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKD 80
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRNlleYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 488984250    81 SILEAIDAGIKLIITITEGI 100
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 7.00e-32

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 113.84  E-value: 7.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250    6 NKDTKVICQGFT--GSQGT-FHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDSI 82
Cdd:pfam02629   1 DKDTKVIVIGAGglGIQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 488984250   83 LEAIDAGIKLIITITEG 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-289 0e+00

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 551.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   2 SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDS 81
Cdd:COG0074    1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  82 ILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYEA 161
Cdd:COG0074   81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 162 VKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPK 241
Cdd:COG0074  161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488984250 242 GKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:COG0074  241 GKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKALK 288
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-289 0e+00

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 549.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   1 MSVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKD 80
Cdd:PRK05678   1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  81 SILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYE 160
Cdd:PRK05678  81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 161 AVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAP 240
Cdd:PRK05678 161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488984250 241 KGKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:PRK05678 241 PGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVLK 289
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 0e+00

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 499.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250    3 VLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDSI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   83 LEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYEAV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  163 KQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPKG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 488984250  243 KRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAII 288
Cdd:TIGR01019 241 KRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 3-289 9.32e-169

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 469.97  E-value: 9.32e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   3 VLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHL--GLPVFNTVREAVEATGATATVIYVPAPFCKD 80
Cdd:PTZ00187  24 VWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTTHLkhGLPVFATVKEAKKATGADASVIYVPPPHAAS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  81 SILEAIDAGIKLIITITEGIPTLDMLTVKVKLDEAGV-RMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTY 159
Cdd:PTZ00187 104 AIIEAIEAEIPLVVCITEGIPQHDMVKVKHALLSQNKtRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVSRSGTLTY 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 160 EAVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVT-KPVVGYIAGVT 238
Cdd:PTZ00187 184 EAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNNPIkKPVVSFIAGIT 263

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488984250 239 APKGKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:PTZ00187 264 APPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVMK 314
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 2-289 2.80e-147

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 414.75  E-value: 2.80e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   2 SVLINKDTKVICQGFTGSQGTFHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDS 81
Cdd:PLN00125   6 AVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAAA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  82 ILEAIDAGIKLIITITEGIPTLDMLTVKVKLD-EAGVRMIGPNCPGVITPGECKIGIMPGHIHKPGKVGIVSRSGTLTYE 160
Cdd:PLN00125  86 ILEAMEAELDLVVCITEGIPQHDMVRVKAALNrQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 161 AVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVT-KPVVGYIAGVTA 239
Cdd:PLN00125 166 AVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGTeKPVVAFIAGLTA 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 488984250 240 PKGKRMGHAGAIIAGGKGTADEKFAALEAAGVKTVRSLADIGEALKAIIK 289
Cdd:PLN00125 246 PPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIGVAMLEVFK 295
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-100 3.68e-33

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 117.23  E-value: 3.68e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250     4 LINKDTKVICQGFTGSQGTFHSEQAIA---YGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKD 80
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMRNlleYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 488984250    81 SILEAIDAGIKLIITITEGI 100
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 7.00e-32

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 113.84  E-value: 7.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250    6 NKDTKVICQGFT--GSQGT-FHSEQAIAYGTQMVGGVTPGKGGTTHLGLPVFNTVREAVEATGATATVIYVPAPFCKDSI 82
Cdd:pfam02629   1 DKDTKVIVIGAGglGIQGLnYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 488984250   83 LEAIDAGIKLIITITEG 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 151-271 1.39e-29

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 108.89  E-value: 1.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  151 VSRSGTLTYEAVKQTTDYGFGQSTCVGIGGDPIPGSNFIDILKMFEEDPQTEAIVMIGEIG-GSAEEEAAAYIK-----D 224
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKaikeaR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 488984250  225 HVTKPVVGYIAGVTAPKGKRMGHAGAIIAGGKGTADEKFAALEAAGV 271
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGA 127
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 45-287 6.12e-29

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 115.69  E-value: 6.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  45 GTTHLGLPVFNTVREAVEATgATATVIYVPAPF--CKDSILEAIDAG-IKLIITITEGIPTLDMLTVKVKLDEAGVRMIG 121
Cdd:PLN02522  57 GQEEIAIPVHGSIEAACKAH-PTADVFINFASFrsAAASSMEALKQPtIRVVAIIAEGVPESDTKQLIAYARANNKVVIG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 122 PNCPGVITPGECKIG--------IMPGHIHKPGKVGIVSRSGTLT---YEAVKQTTDygfGQSTCVGIGGDPIPGSNFID 190
Cdd:PLN02522 136 PATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSnemYNVIARVTD---GIYEGIAIGGDVFPGSTLSD 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 191 ILKMFEEDPQTEAIVMIGEIGGSAEEEAAAYIKD-HVTKPVVGYIAGVTA---PKGKRMGHAGAIIAGGKGTADEKFAAL 266
Cdd:PLN02522 213 HVLRFNNIPQIKMIVVLGELGGRDEYSLVEALKQgKVSKPVVAWVSGTCArlfKSEVQFGHAGAKSGGDMESAQAKNKAL 292

                        250       260
                 ....*....|....*....|.
gi 488984250 267 EAAGVKTVRSLADIGEALKAI 287
Cdd:PLN02522 293 KDAGAIVPTSFEALEAAIKET 313
PRK06091 PRK06091
membrane protein FdrA; Validated
 42-241 4.96e-07

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 50.81  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250  42 GKGGTThlGLPVFNTVREAVE-ATGATATVIYVPAPFCKDSILEAIDAGIKLIItITEGIPTLDMLTVKVKLDEAGVRMI 120
Cdd:PRK06091  95 GSGSSQ--SLTQVRRWDSACQkLPDANLALISVAGEYAAELAEQALDRNLNVMM-FSDNVTLEDEIRLKTRAREKGLLVM 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250 121 GPNCpgvitpGECKIGIMP---GHIHKPGKVGIVSRSGTLTYEAVKQTTDYGFGQSTCVGIGG----DPIPGSNFIDILK 193
Cdd:PRK06091 172 GPDC------GTAMIAGTPlafANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGrdlsAEVGGISALTALE 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488984250 194 MFEEDPQTEAIVMIGEIGGSAEEEAAAYIKDHVTKPVVGYIAGVTAPK 241
Cdd:PRK06091 246 MLSADEKSEVIAFVSKPPAEAVRLKIINAMKATGKPVVALFLGYTPAV 293
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 36-130 3.65e-04

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 39.44  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984250   36 VGGVTPGKGgtTHLGLPVFNTVREAVEAtgATATVIYVPAPFCKDSILEAIDAGIKLIItITEGIPTLDMLTvkvKLDEA 115
Cdd:pfam13380  30 VIPVNPKAK--EILGEPVYPSLADPPEP--VDLVDVFRPPEAVPEIVEEALALGAKAVW-LQPGIENEEAAA---IARAA 101

                          90
                  ....*....|....*
gi 488984250  116 GVRMIGPNCPGVITP 130
Cdd:pfam13380 102 GIRVVGDRCLGVEHP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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