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Conserved domains on  [gi|488984960|ref|WP_002895746|]
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MULTISPECIES: transcriptional regulator CecR [Klebsiella]

Protein Classification

transcriptional regulator( domain architecture ID 11485390)

HTH-type transcriptional regulator CecR/YbiH regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-218 6.60e-142

putative DNA-binding transcriptional regulator; Provisional


:

Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 395.19  E-value: 6.60e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   1 MTSKGEQAKNQLIAAAIAQFGEYGQHATTRDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIGDNFRPQAEAAEHLL 80
Cdd:PRK11552   7 MTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEEAERLF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  81 AGEAPDRQAIRDLILSACHNMILLLTQDDTVNLSKFISREQLAPTAAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQM 160
Cdd:PRK11552  87 AQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDANDTRT 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488984960 161 ILHTHALLGEVLAFRLGRETILLRTGWTQFDAQKTEQIFEVITCHIDFILHGLSQRSL 218
Cdd:PRK11552 167 ILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSL 224
 
Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-218 6.60e-142

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 395.19  E-value: 6.60e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   1 MTSKGEQAKNQLIAAAIAQFGEYGQHATTRDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIGDNFRPQAEAAEHLL 80
Cdd:PRK11552   7 MTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEEAERLF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  81 AGEAPDRQAIRDLILSACHNMILLLTQDDTVNLSKFISREQLAPTAAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQM 160
Cdd:PRK11552  87 AQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDANDTRT 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488984960 161 ILHTHALLGEVLAFRLGRETILLRTGWTQFDAQKTEQIFEVITCHIDFILHGLSQRSL 218
Cdd:PRK11552 167 ILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSL 224
CecR_C pfam09209
HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the ...
90-213 9.47e-42

HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the C-terminal domain found in CecR (regulator of cefoperazone and chloramphenicol sensitivity), previously known as YbiH. CecR has been shown to control sensitivity to cefoperazone and chloramphenicol through regulating the transcription of the cecR-ybhGFSR operon and the rhlE gene.


Pssm-ID: 430467  Cd Length: 125  Bit Score: 137.80  E-value: 9.47e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   90 IRDLILSACHNMI-LLLTQDDTVNLSKFISREQLAPTAAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQMILHTHALL 168
Cdd:pfam09209   1 ARERLRAFIRRMLaRIASEDEPEWWGRFMAREQAEPTGALDRIYKGVIKPLHAALCRIVAELLGEDADDESVRLCTLSIV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 488984960  169 GEVLAFRLGRETILLRTGWTQFDAQKTEQIFEVITCHIDFILHGL 213
Cdd:pfam09209  81 GQCLHFRVAREAVLRLLGWLTFDPEEIDDIAALAEHILRFSLAGL 125
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
2-164 5.51e-11

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 58.76  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   2 TSKGEQAKNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIgdnfrpqAEAAEHLL 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSvRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEEL-------LAALEEAL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  81 AGEAPdRQAIRDLILSACHNMillltQDDTVNLSKFISREQLAPtaAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQM 160
Cdd:COG1309   74 AAEDP-RERLRALLRAYLEFL-----AENPALARLLLAEAAELP--ELRAALRALLRRLRALLAELLRAGGLLADVDPDA 145

                 ....
gi 488984960 161 ILHT 164
Cdd:COG1309  146 LARA 149
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
9-120 4.63e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 48.29  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   9 KNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACaqwIADFIgDNFRPQAEAAEHLLAGEAPD- 86
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSvRDIAKKAKVNVALISYYFKGKQGLLEYL---VTSFF-EGYLEILEEGFEELKNLSAKe 76
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488984960  87 --RQAIRDLILSACHNMillltqddtvNLSKFISRE 120
Cdd:NF037937  77 clKQLVRNILHYQQEHH----------QLTRFVHRE 102
 
Name Accession Description Interval E-value
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
1-218 6.60e-142

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 395.19  E-value: 6.60e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   1 MTSKGEQAKNQLIAAAIAQFGEYGQHATTRDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIGDNFRPQAEAAEHLL 80
Cdd:PRK11552   7 MTTRGEQAKQQLIAAALAQFGEYGLHATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGEQFRPHAEEAERLF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  81 AGEAPDRQAIRDLILSACHNMILLLTQDDTVNLSKFISREQLAPTAAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQM 160
Cdd:PRK11552  87 AQPAPDRAAIRELILRACLNMIKLLTQDDTVNLSKFISREQLSPTAAYHLIHEQVISPLHSHLTRLIAAYTGCDANDTRT 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488984960 161 ILHTHALLGEVLAFRLGRETILLRTGWTQFDAQKTEQIFEVITCHIDFILHGLSQRSL 218
Cdd:PRK11552 167 ILHTHALIGEVLAFRLGRETILLRTGWTQFDEEKAELINQVVTCHIDLILNGLRQRSL 224
CecR_C pfam09209
HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the ...
90-213 9.47e-42

HTH-type transcriptional dual regulator CecR, C-terminal domain; This entry represents the C-terminal domain found in CecR (regulator of cefoperazone and chloramphenicol sensitivity), previously known as YbiH. CecR has been shown to control sensitivity to cefoperazone and chloramphenicol through regulating the transcription of the cecR-ybhGFSR operon and the rhlE gene.


Pssm-ID: 430467  Cd Length: 125  Bit Score: 137.80  E-value: 9.47e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   90 IRDLILSACHNMI-LLLTQDDTVNLSKFISREQLAPTAAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQMILHTHALL 168
Cdd:pfam09209   1 ARERLRAFIRRMLaRIASEDEPEWWGRFMAREQAEPTGALDRIYKGVIKPLHAALCRIVAELLGEDADDESVRLCTLSIV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 488984960  169 GEVLAFRLGRETILLRTGWTQFDAQKTEQIFEVITCHIDFILHGL 213
Cdd:pfam09209  81 GQCLHFRVAREAVLRLLGWLTFDPEEIDDIAALAEHILRFSLAGL 125
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
2-164 5.51e-11

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 58.76  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   2 TSKGEQAKNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIgdnfrpqAEAAEHLL 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSvRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEEL-------LAALEEAL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  81 AGEAPdRQAIRDLILSACHNMillltQDDTVNLSKFISREQLAPtaAYHLIHQQVIAPLHHYLTRLIAAWTGCEASDTQM 160
Cdd:COG1309   74 AAEDP-RERLRALLRAYLEFL-----AENPALARLLLAEAAELP--ELRAALRALLRRLRALLAELLRAGGLLADVDPDA 145

                 ....
gi 488984960 161 ILHT 164
Cdd:COG1309  146 LARA 149
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
4-97 5.95e-10

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 56.49  E-value: 5.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   4 KGEQAKNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIGDNFRPQAEAAEhllaG 82
Cdd:COG3226    5 RGEERRERILEAALRVIARDGVRGVThRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAAD----D 80
                         90
                 ....*....|....*
gi 488984960  83 EAPDRQAIRDLILSA 97
Cdd:COG3226   81 LEDAAEALADLLAEL 95
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
12-57 8.81e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.41  E-value: 8.81e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 488984960   12 LIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLAC 57
Cdd:pfam00440   1 ILDAARELFAERGYDATTvREIAKRAGVSKGALYRYFGSKEELLEAL 47
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
9-120 4.63e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 48.29  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   9 KNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACaqwIADFIgDNFRPQAEAAEHLLAGEAPD- 86
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSvRDIAKKAKVNVALISYYFKGKQGLLEYL---VTSFF-EGYLEILEEGFEELKNLSAKe 76
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488984960  87 --RQAIRDLILSACHNMillltqddtvNLSKFISRE 120
Cdd:NF037937  77 clKQLVRNILHYQQEHH----------QLTRFVHRE 102
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
3-142 3.75e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 46.07  E-value: 3.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960   3 SKGEQAKNQLI-AAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADF-------IGDNFRPQA 73
Cdd:PRK15008  13 SRAVSAKKKAIlSAALDTFSQFGFHGTRlEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIwlaplkaFREDFAPLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  74 EAAEHLLAGEAPDR---QAIRDLILSACHNMILLLTQ----------DDTVNLSKFISREQLAPTAAYHLIHqQVIAPLH 140
Cdd:PRK15008  93 AIKEYIRLKLEVSRdypQASRLFCMEMLAGAPLLMDEltgdlkalidEKSALIAGWVKSGKLAPIDPQHLIF-MIWASTQ 171

                 ..
gi 488984960 141 HY 142
Cdd:PRK15008 172 HY 173
PRK00767 PRK00767
transcriptional regulator BetI; Validated
11-94 2.33e-05

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 43.68  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488984960  11 QLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLYLACAQWIADFIGDnfrpqaEAAEHLLAGEAPDRQA 89
Cdd:PRK00767  13 QLIDATLRAIGEVGLLDATiAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGD------AVLARLAAAADTPRAR 86

                 ....*
gi 488984960  90 IRDLI 94
Cdd:PRK00767  87 LRAIV 91
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
9-54 1.33e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.57  E-value: 1.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488984960   9 KNQLIAAAIAQFGEYG-QHATTRDIAAQAGQNIAAITYYFGSKDDLY 54
Cdd:PRK09975  13 RQELIETAIAQFALRGvSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
6-54 7.67e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 36.14  E-value: 7.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488984960   6 EQAKNQLIAAAIAQFGEYGQHATT-RDIAAQAGQNIAAITYYFGSKDDLY 54
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSlADIAKAAGVTRGAIYWHFKNKSDLF 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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