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Conserved domains on  [gi|488987404|ref|WP_002898187|]
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MULTISPECIES: tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM [Klebsiella]

Protein Classification

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM( domain architecture ID 11485161)

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM is a class I SAM-dependent methyltransferase that catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs, using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
1-255 0e+00

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


:

Pssm-ID: 182918  Cd Length: 255  Bit Score: 527.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   1 MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVA 80
Cdd:PRK11036   1 MQDRNFDDIAEKFSRNIYGTTKGQIRQAILWQDLDRLLAELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  81 RARQAAADKGVIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYNANGLLMHNM 160
Cdd:PRK11036  81 RAKQAAEAKGVSDNMQFIHCAAQDIAQHLETPVDLILFHAVLEWVADPKSVLQTLWSVLRPGGALSLMFYNANGLLMHNM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404 161 VAGNFDYVQLGMPKKKKRTLSPDYPREPQQVYHWLEEIGWQIVSKTGVRVFHDYLREKRQQHDSYAALLALETRYCRQEP 240
Cdd:PRK11036 161 VAGNFDYVQAGMPKRKKRTLSPDYPLDPEQVYQWLEEAGWQIMGKTGVRVFHDYLRNKHQQRDCFEALLELEQRYCRQEP 240

                        250
                 ....*....|....*
gi 488987404 241 YLSLGRYIHVTALKS 255
Cdd:PRK11036 241 YISLGRYIHVTARKP 255
 
Name Accession Description Interval E-value
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
1-255 0e+00

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 527.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   1 MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVA 80
Cdd:PRK11036   1 MQDRNFDDIAEKFSRNIYGTTKGQIRQAILWQDLDRLLAELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  81 RARQAAADKGVIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYNANGLLMHNM 160
Cdd:PRK11036  81 RAKQAAEAKGVSDNMQFIHCAAQDIAQHLETPVDLILFHAVLEWVADPKSVLQTLWSVLRPGGALSLMFYNANGLLMHNM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404 161 VAGNFDYVQLGMPKKKKRTLSPDYPREPQQVYHWLEEIGWQIVSKTGVRVFHDYLREKRQQHDSYAALLALETRYCRQEP 240
Cdd:PRK11036 161 VAGNFDYVQAGMPKRKKRTLSPDYPLDPEQVYQWLEEAGWQIMGKTGVRVFHDYLRNKHQQRDCFEALLELEQRYCRQEP 240

                        250
                 ....*....|....*
gi 488987404 241 YLSLGRYIHVTALKS 255
Cdd:PRK11036 241 YISLGRYIHVTARKP 255
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-151 1.30e-29

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 108.18  E-value: 1.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  33 DLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQAAADKGVidnmHFVQCAAQDIAQHLESp 112
Cdd:COG2227   13 RLAALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNV----DFVQGDLEDLPLEDGS- 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488987404 113 VDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYN 151
Cdd:COG2227   88 FDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-143 1.38e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 78.37  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   48 VLDAGGGEGQTAIKVAQ-LGHHVTLCDLSAEMVARARQAAADKGVidNMHFVQCAAQDIAQHLESpVDLVLFHAVLEWVA 126
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGS-FDLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 488987404  127 EPQ--EILHTLWSTLRAGG 143
Cdd:pfam13649  78 DPDleAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-150 1.90e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 67.46  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  47 RVLDAGGGEGQTAIKVAQL-GHHVTLCDLSAEMVARARQAAAdKGVIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWV 125
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*.
gi 488987404 126 AE-PQEILHTLWSTLRAGGGLSLMFY 150
Cdd:cd02440   80 VEdLARFLEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
1-255 0e+00

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 527.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   1 MQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVA 80
Cdd:PRK11036   1 MQDRNFDDIAEKFSRNIYGTTKGQIRQAILWQDLDRLLAELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  81 RARQAAADKGVIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYNANGLLMHNM 160
Cdd:PRK11036  81 RAKQAAEAKGVSDNMQFIHCAAQDIAQHLETPVDLILFHAVLEWVADPKSVLQTLWSVLRPGGALSLMFYNANGLLMHNM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404 161 VAGNFDYVQLGMPKKKKRTLSPDYPREPQQVYHWLEEIGWQIVSKTGVRVFHDYLREKRQQHDSYAALLALETRYCRQEP 240
Cdd:PRK11036 161 VAGNFDYVQAGMPKRKKRTLSPDYPLDPEQVYQWLEEAGWQIMGKTGVRVFHDYLRNKHQQRDCFEALLELEQRYCRQEP 240

                        250
                 ....*....|....*
gi 488987404 241 YLSLGRYIHVTALKS 255
Cdd:PRK11036 241 YISLGRYIHVTARKP 255
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 33-151 1.30e-29

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 108.18  E-value: 1.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  33 DLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQAAADKGVidnmHFVQCAAQDIAQHLESp 112
Cdd:COG2227   13 RLAALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNV----DFVQGDLEDLPLEDGS- 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488987404 113 VDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYN 151
Cdd:COG2227   88 FDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 5.52e-21

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 86.20  E-value: 5.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  26 RQAILWQDLEPLLAQLGPGP-LRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQAAADKGVidNMHFVQCAAQD 104
Cdd:COG2226    3 RVAARYDGREALLAALGLRPgARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAED 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488987404 105 IAQHLESpVDLVLFHAVLEWVAEPQEILHTLWSTLRAGG 143
Cdd:COG2226   81 LPFPDGS-FDLVISSFVLHHLPDPERALAEIARVLKPGG 118
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-143 1.38e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 78.37  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   48 VLDAGGGEGQTAIKVAQ-LGHHVTLCDLSAEMVARARQAAADKGVidNMHFVQCAAQDIAQHLESpVDLVLFHAVLEWVA 126
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGS-FDLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 488987404  127 EPQ--EILHTLWSTLRAGG 143
Cdd:pfam13649  78 DPDleAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
44-143 2.42e-18

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 77.94  E-value: 2.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  44 GPLRVLDAGGGEGQTAIKVAQL--GHHVTLCDLSAEMVARARQAAAdkgvidNMHFVQCAAQDIAqhLESPVDLVLFHAV 121
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLP------NVRFVVADLRDLD--PPEPFDLVVSNAA 72

                         90       100
                 ....*....|....*....|..
gi 488987404 122 LEWVAEPQEILHTLWSTLRAGG 143
Cdd:COG4106   73 LHWLPDHAALLARLAAALAPGG 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-163 3.71e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 77.26  E-value: 3.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  18 YGTTKGQLRQAILWQDLEPLlaqlgPGPLRVLDAGGGEGQTAIKVAQL-GHHVTLCDLSAEMVARARQAAADKGvIDNMH 96
Cdd:COG0500    5 YYSDELLPGLAALLALLERL-----PKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAG-LGNVE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488987404  97 FVQCAAQDIAQHLESPVDLVLFHAVLEWV--AEPQEILHTLWSTLRAGGGLSLMFYNANGLLMHNMVAG 163
Cdd:COG0500   79 FLVADLAELDPLPAESFDLVVAFGVLHHLppEEREALLRELARALKPGGVLLLSASDAAAALSLARLLL 147
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
6-143 6.24e-16

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 73.49  E-value: 6.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   6 FDDIAEKFSRNIYGTTKGQLRQAILwqdlEPLLAQLGPGP-LRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQ 84
Cdd:COG4976   11 FDQYADSYDAALVEDLGYEAPALLA----EELLARLPPGPfGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKARE 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488987404  85 aaadKGVIDNMHfvqcaAQDIAQ--HLESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGG 143
Cdd:COG4976   87 ----KGVYDRLL-----VADLADlaEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGG 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-143 7.75e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 68.08  E-value: 7.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   49 LDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQAAADKGVidnmHFVQCAAQDIAQHLESpVDLVLFHAVLEWVAEP 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGL----TFVVGDAEDLPFPDNS-FDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*
gi 488987404  129 QEILHTLWSTLRAGG 143
Cdd:pfam08241  76 ERALREIARVLKPGG 90
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-150 1.90e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 67.46  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  47 RVLDAGGGEGQTAIKVAQL-GHHVTLCDLSAEMVARARQAAAdKGVIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWV 125
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....*.
gi 488987404 126 AE-PQEILHTLWSTLRAGGGLSLMFY 150
Cdd:cd02440   80 VEdLARFLEEARRLLKPGGVLVLTLV 105
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-145 6.38e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 65.85  E-value: 6.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   49 LDAGGGEGQTAIKVAQLGH--HVTLCDLSAEMVARARQAAADKGvIDNMHFVQCAAQDIAQHLESPVDLVLFHAVLEWVA 126
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPglEYTGLDISPAALEAARERLAALG-LLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*....
gi 488987404  127 EPQEILHTLWSTLRAGGGL 145
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 4-143 1.94e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 66.11  E-value: 1.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   4 RNFDDIAEKFSRNIYGTTKGQLRQAILWQdLEPLLAQLGPGP-LRVLDAGGGEGQTAIKVAQ-LGHHVTLCDLSAEMVAR 81
Cdd:COG2230   11 RLFLDPTMTYSCAYFEDPDDTLEEAQEAK-LDLILRKLGLKPgMRVLDIGCGWGGLALYLARrYGVRVTGVTLSPEQLEY 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488987404  82 ARQAAADKGVIDNMHFVQCAAQDIAqhLESPVDLVLFHAVLEWVAEPQ--EILHTLWSTLRAGG 143
Cdd:COG2230   90 ARERAAEAGLADRVEVRLADYRDLP--ADGQFDAIVSIGMFEHVGPENypAYFAKVARLLKPGG 151
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-199 2.85e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 65.52  E-value: 2.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   46 LRVLDAGGGEGQTAIKVAQL---GHHVTLCDLSAEMVARARQAAADKGvIDNMHFVQCAAQDIAQHLE-SPVDLVLFHAV 121
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEElgpNAEVVGIDISEEAIEKARENAQKLG-FDNVEFEQGDIEELPELLEdDKFDVVISNCV 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488987404  122 LEWVAEPQEILHTLWSTLRAGGGLSLMFYNANGLLMHNMVAGNFDYVQLgmpkkkkrtlsPDYPREPQQVYHWLEEIG 199
Cdd:pfam13847  84 LNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGC-----------VGGAILKKKLYELLEEAG 150
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 43-205 2.50e-11

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 61.78  E-value: 2.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  43 PGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARARQAAADKGVIDNMHFvqcAAQDIAQHLESpvdlvlFHAVl 122
Cdd:PRK07580  62 LTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAGNITF---EVGDLESLLGR------FDTV- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404 123 ewVA------EPQE----ILHTLWStlRAGGGLSLMF--YNANGLLMHNMvaGNFdyvqlgMPKKKKRTLSpdYPREPQQ 190
Cdd:PRK07580 132 --VCldvlihYPQEdaarMLAHLAS--LTRGSLIFTFapYTPLLALLHWI--GGL------FPGPSRTTRI--YPHREKG 197

                        170
                 ....*....|....*
gi 488987404 191 VYHWLEEIGWQIVSK 205
Cdd:PRK07580 198 IRRALAAAGFKVVRT 212
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 30-204 2.17e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 52.43  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   30 LWQDLEPLLAQLGPGPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARArqaaadkgvIDNMHFVQCAAQDIAQhL 109
Cdd:pfam13489   8 LLADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERA---------LLNVRFDQFDEQEAAV-P 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  110 ESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLMFYNANgLLMHNMvagnFDYVQLGMPKKKKRTLspdYPREpq 189
Cdd:pfam13489  78 AGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLAS-DEADRL----LLEWPYLRPRNGHISL---FSAR-- 147

                         170
                  ....*....|....*
gi 488987404  190 QVYHWLEEIGWQIVS 204
Cdd:pfam13489 148 SLKRLLEEAGFEVVS 162
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 39-105 4.92e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 49.38  E-value: 4.92e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488987404  39 AQLGPGP-LRVLDAGGGEGQTAIKVAQLGH---HVTLCDLSAEMVARARQAAADKGVIDNMHFVQCAAQDI 105
Cdd:PRK00216  45 KWLGVRPgDKVLDLACGTGDLAIALAKAVGktgEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEAL 115
PRK08317 PRK08317
hypothetical protein; Provisional
 38-143 5.06e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.55  E-value: 5.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  38 LAQLGPGPlRVLDAGGGEGQTAIKVAQL---GHHVTLCDLSAEMVARARQAAADKGviDNMHFVqcaaQDIAQHLESP-- 112
Cdd:PRK08317  14 LLAVQPGD-RVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLG--PNVEFV----RGDADGLPFPdg 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 488987404 113 -VDLVLFHAVLEWVAEPQEILHTLWSTLRAGG 143
Cdd:PRK08317  87 sFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 37-166 1.63e-06

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 48.15  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  37 LLAQLG-PGPLRVLDAGGGEGQTAIKVAQL--GHHVTLCDLSAEMVARARQAAADKGVIDNMHFVQcaaqdiaqhlESPV 113
Cdd:PRK14103  21 LLARVGaERARRVVDLGCGPGNLTRYLARRwpGAVIEALDSSPEMVAAARERGVDARTGDVRDWKP----------KPDT 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488987404 114 DLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLSLmfynangllmhnMVAGNFD 166
Cdd:PRK14103  91 DVVVSNAALQWVPEHADLLVRWVDELAPGSWIAV------------QVPGNFD 131
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
47-117 4.66e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 46.57  E-value: 4.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488987404  47 RVLDAGGGEGQTAIKVAQLG-HHVTLCDLSAEMVARARQAAADKGVIDNMHFVQCAAQDIaqHLESPVDLVL 117
Cdd:COG4076   38 VVLDIGTGSGLLSMLAARAGaKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDL--DLPEKADVII 107
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 32-143 5.50e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 46.29  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  32 QDLEPLLAQLGP-GPLRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVARAR-QAAADkgvidnmHFVQCAAQDIAqHL 109
Cdd:PRK10258  29 QSADALLAMLPQrKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARqKDAAD-------HYLAGDIESLP-LA 100

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488987404 110 ESPVDLVLFHAVLEWVAEPQEILHTLWSTLRAGG 143
Cdd:PRK10258 101 TATFDLAWSNLAVQWCGNLSTALRELYRVVRPGG 134
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 34-120 3.96e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 42.56  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   34 LEPLLAQLG--PGPLRVLDAGGGEGQTAIKVAQLGHHVTLC--DLSAEMVARARQAAADKGVIDNMHFVQCA-AQDIAQH 108
Cdd:pfam13679  13 IAPLLKELLdeNGPITIVDHGAGKGYLGFILYYLKYGVRVYgiDTRAELVEKANALAQKLGFNKRMSFLEGTiAGSTPVE 92

                          90
                  ....*....|...
gi 488987404  109 LESPVDLVL-FHA 120
Cdd:pfam13679  93 LPDRVDVVTaLHA 105
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 38-138 8.42e-05

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 43.02  E-value: 8.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  38 LAQLGPGPLRVLDAGGGEGQTAIKVAQLGH---HVTLCDLSAEMVARARQ--AAADKGVIDNMHFVQCaaqDIAQHLESP 112
Cdd:COG5459   74 EAGPDFAPLTVLDVGAGPGTAAWAAADAWPsllDATLLERSAAALALGRRlaRAAANPALETAEWRLA---DLAAALPAP 150

                         90       100
                 ....*....|....*....|....*....
gi 488987404 113 -VDLVLFHAVLEWVAEPQ--EILHTLWST 138
Cdd:COG5459  151 pADLVVASYVLNELADAAraALVDRLWLA 179
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 37-145 1.13e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 42.62  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  37 LLAQLG-PGPLRVLDAGGGEGQ-TAIKVAQLGH-HVTLCDLSAEMVARARQAAADkgvidnMHFVQCaaqDIAQ-HLESP 112
Cdd:PRK01683  23 LLARVPlENPRYVVDLGCGPGNsTELLVERWPAaRITGIDSSPAMLAEARSRLPD------CQFVEA---DIASwQPPQA 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 488987404 113 VDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGL 145
Cdd:PRK01683  94 LDLIFANASLQWLPDHLELFPRLVSLLAPGGVL 126
PRK14967 PRK14967
putative methyltransferase; Provisional
 41-117 3.42e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 40.81  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  41 LGPGPlRVLDAGGGEGQTAIKVAQLG-HHVTLCDLSAEMVARARQAAADKGV-IDNMHfvqcaaQDIAQHLE-SPVDLVL 117
Cdd:PRK14967  34 LGPGR-RVLDLCTGSGALAVAAAAAGaGSVTAVDISRRAVRSARLNALLAGVdVDVRR------GDWARAVEfRPFDVVV 106
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 38-153 4.68e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.53  E-value: 4.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  38 LAQLGPGP-LRVLDAGGGEGQTAIKVAQL----GHHVTLcDLSAEMVARARQAAADKGVIDNMHFVQcaaQDIAQHL-ES 111
Cdd:COG2519   84 IARLDIFPgARVLEAGTGSGALTLALARAvgpeGKVYSY-ERREDFAEIARKNLERFGLPDNVELKL---GDIREGIdEG 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 488987404 112 PVDLVlfhaVLEwVAEPQEILHTLWSTLRAGGglSLMFYNAN 153
Cdd:COG2519  160 DVDAV----FLD-MPDPWEALEAVAKALKPGG--VLVAYVPT 194
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 15-97 1.74e-03

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 39.07  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  15 RNIYGTT----KGQL--RQ--------AILWQDLEPLLAQLgpgplRVLDAGGGEGQTAIKVAQLGHHVTLCDLSAEMVA 80
Cdd:PLN02585 106 RKIYGETdevnKVQLdiRLghaqtvekVLLWLAEDGSLAGV-----TVCDAGCGTGSLAIPLALEGAIVSASDISAAMVA 180

                         90       100
                 ....*....|....*....|.
gi 488987404  81 ----RARQAAADKGVIDNMHF 97
Cdd:PLN02585 181 eaerRAKEALAALPPEVLPKF 201
arsM PRK11873
arsenite methyltransferase;
38-146 3.93e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 38.01  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404  38 LAQLGPGPlRVLDAGGGEGQ----TAIKVAQLGHhVTLCDLSAEMVARARqAAADKGVIDNMHFVQcaaQDIaQHLESP- 112
Cdd:PRK11873  72 LAELKPGE-TVLDLGSGGGFdcflAARRVGPTGK-VIGVDMTPEMLAKAR-ANARKAGYTNVEFRL---GEI-EALPVAd 144

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488987404 113 --VDLVLFHAVLEWVAEPQEILHTLWSTLRAGGGLS 146
Cdd:PRK11873 145 nsVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFA 180
PRK06202 PRK06202
hypothetical protein; Provisional
 32-91 5.64e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 37.29  E-value: 5.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488987404  32 QDLEPLLAQlgPGPLRVLDAGGGEGQTAIKVAQLGHH------VTLCDLSAEMVARARQAAADKGV 91
Cdd:PRK06202  50 RLLRPALSA--DRPLTLLDIGCGGGDLAIDLARWARRdglrleVTAIDPDPRAVAFARANPRRPGV 113
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 47-120 7.80e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.41  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488987404   47 RVLDAGGGEGQTAIKVAQLG--HHVTLCDLSAEMVARARQAAADKGViDNMHFVqcaAQDIAQHLES-PVDLVL----FH 119
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESpdAELTMVDINARALESARENLAANGL-ENGEVV---ASDVYSGVEDgKFDLIIsnppFH 109


                  .
gi 488987404  120 A 120
Cdd:pfam05175 110 A 110
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 37-99 8.01e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 36.60  E-value: 8.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488987404  37 LLAQLGPGPL-RVLDAGGGEG-QTAIkVAQLGHHVTLCDLSAEMVARARQAAADKGvIDNMHFVQ 99
Cdd:COG2518   58 MLEALDLKPGdRVLEIGTGSGyQAAV-LARLAGRVYSVERDPELAERARERLAALG-YDNVTVRV 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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