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Conserved domains on  [gi|488991141|ref|WP_002901901|]
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MULTISPECIES: MFS transporter [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 5.25e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.47  E-value: 5.25e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIava 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldvggllslivalvlvnlfiskghgwgwssPLSLTMLAGAlaagtifirngmrkgeaa 260
Cdd:cd17321  158 ----------------------------------------------------PIGLVALLLA------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 340 AGPVLTAIAIALISctFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488991141 420 ASLFALFLPLGM----------------AHAAQYALWFNAVLCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 5.25e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.47  E-value: 5.25e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIava 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldvggllslivalvlvnlfiskghgwgwssPLSLTMLAGAlaagtifirngmrkgeaa 260
Cdd:cd17321  158 ----------------------------------------------------PIGLVALLLA------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 340 AGPVLTAIAIALISctFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488991141 420 ASLFALFLPLGM----------------AHAAQYALWFNAVLCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-423 6.54e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 100.92  E-value: 6.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   17 LLVGIVLSVLTfwlfaQSVINV-VPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:TIGR00711   7 LMLGTFMAVLD-----STIVNVaIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  176 SIAVALLALFLLRGTPESRSASASQhKLDVGGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMR 255
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASE-NFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  256 KGEAALIDFALFRNRAYGAAVLSNFLLN-GAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGlGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  335 RLPMMAGPVLTAIAIALISCTFLEKALYIGVVFASNVLfGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAM 414
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIR-GFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399


                  ....*....
gi 488991141  415 GIAVTASLF 423
Cdd:TIGR00711 400 GTALITTIL 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-413 9.95e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 9.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 176 siavallalfllrgtpesrsasasqhkldVGGLLSLIVALVLVnlfiskghgwgWSSPLSLTMLAGALAAGTifirngmr 255
Cdd:COG2814  169 -----------------------------VNAVLALLALLLLL-----------RLLPESRPAARARLRGSL-------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 256 kgeaalidFALFRNRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:COG2814  201 --------RELLRRPRLLLLLLLAFLLGFGFFALFtYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141 335 RLPMMAGPVLTAIAIALISCTFLEKALYIGVvfasnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:COG2814  273 RRLLLIGLLLLALGLLLLALAGSLWLLLLAL-----FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
17-415 2.05e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.15  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   17 LLVGIVLSVLTFWLFAqsvINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSA 96
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   97 MLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  177 iavallalfllrgtpesrsasasqhkldvgGLLSLIVALVLvnlfiskghgwgwssplsltmLAGALAAGTIFIRNGMRK 256
Cdd:pfam07690 158 ------------------------------AILSLLAAVLL---------------------LLPRPPPESKRPKPAEEA 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  257 GEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARL 336
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141  337 PMMAGpvLTAIAIALISCTFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:pfam07690 267 RLLLA--LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
18-418 2.57e-15

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 77.85  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  18 LVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAM 97
Cdd:PRK14995   8 LVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  98 LVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWY-EGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:PRK14995  88 AAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLIN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 177 I-AVALLALFLLRGTPesRSASASQHKLDVGGLLSLIVALVLVNLFISKG-HGWGWSSPLSLTMLAGALAAGtIFIRNGM 254
Cdd:PRK14995 168 VpIVLVVMGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTAlKGFLSLWVTSLTLLTGALLLG-LFIRTQL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 255 RkGEAALIDFALFRNRAYGAAV-LSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:PRK14995 245 A-ASRPMIDMRLFTHRIILSGVvMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 334 ARLPMMAGPVLTAIAIALISCTFLEKALYIGvvFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:PRK14995 324 LRLVATGGMALSALSFYGLAMTDFSTQQWQA--WGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAG 401


                 ....*
gi 488991141 414 MGIAV 418
Cdd:PRK14995 402 LGIAI 406
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 5.25e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.47  E-value: 5.25e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIava 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldvggllslivalvlvnlfiskghgwgwssPLSLTMLAGAlaagtifirngmrkgeaa 260
Cdd:cd17321  158 ----------------------------------------------------PIGLVALLLA------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 340 AGPVLTAIAIALISctFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488991141 420 ASLFALFLPLGM----------------AHAAQYALWFNAVLCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-456 7.96e-27

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 111.13  E-value: 7.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  33 QSVINV-VPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGR 111
Cdd:cd17503   12 TTIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 112 VLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVAllalfllrgtp 191
Cdd:cd17503   92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG----------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 192 esrsasasqhkldvggllslIVALVLvnlfiskghgwgwssplsltmlagalaagtifirngmrkgeAALIDFALFRNRA 271
Cdd:cd17503  161 --------------------ILALLL-----------------------------------------APLLDLRLFKDRN 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 272 YGAAVLSNFLLNGAI-GTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIA 350
Cdd:cd17503  180 FTLGLLLSFLLGLGLfGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 351 LISCTFLEKALYIgvVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF---- 426
Cdd:cd17503  260 LLAFLTPDTSLWL--IILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtqfh 337

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 488991141 427 ------------LPLGMAHAAQYALWFNAVLCLGAMAVSALL 456
Cdd:cd17503  338 hsrlsellaqqvQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-423 6.54e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 100.92  E-value: 6.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   17 LLVGIVLSVLTfwlfaQSVINV-VPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:TIGR00711   7 LMLGTFMAVLD-----STIVNVaIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  176 SIAVALLALFLLRGTPESRSASASQhKLDVGGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMR 255
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAASE-NFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  256 KGEAALIDFALFRNRAYGAAVLSNFLLN-GAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGlGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  335 RLPMMAGPVLTAIAIALISCTFLEKALYIGVVFASNVLfGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAM 414
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIR-GFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399


                  ....*....
gi 488991141  415 GIAVTASLF 423
Cdd:TIGR00711 400 GTALITTIL 408
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-413 9.95e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 9.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 176 siavallalfllrgtpesrsasasqhkldVGGLLSLIVALVLVnlfiskghgwgWSSPLSLTMLAGALAAGTifirngmr 255
Cdd:COG2814  169 -----------------------------VNAVLALLALLLLL-----------RLLPESRPAARARLRGSL-------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 256 kgeaalidFALFRNRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:COG2814  201 --------RELLRRPRLLLLLLLAFLLGFGFFALFtYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141 335 RLPMMAGPVLTAIAIALISCTFLEKALYIGVvfasnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:COG2814  273 RRLLLIGLLLLALGLLLLALAGSLWLLLLAL-----FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 5-296 1.21e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 91.80  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   5 TISDTPFVGNDRLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMT 84
Cdd:COG0477    3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  85 TIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIA 164
Cdd:COG0477   83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 165 TGLGWRWIFVFSIAVALLALFLLRGTPESRSASASQHKLDVGGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALA 244
Cdd:COG0477  163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488991141 245 AGTIFIRNGMRKGEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWL 296
Cdd:COG0477  243 LALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 21-457 4.38e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 88.40  E-value: 4.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIava 180
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA--- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldVGGLLSLIVALVLVNLFISKGHgwgwssplsltmlagalaagtifiRNGMRKGEAA 260
Cdd:cd17325  158 ------------------------ALALLALVLALLLLPEPRPPPN------------------------KRAVSAARLR 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 LIDFALFRNRAYGAAVLSNFLLNGAIGTMMIA-SIWLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGeKLLQRYGARLPM 338
Cdd:cd17325  190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFlPLYAAELGGLSPAQIGLLfGAQGLASALSQPPAG-KLSDRIGRKPLI 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 339 MAGPVLTAIAIALISctfleKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAV 418
Cdd:cd17325  269 LIGLLLSAVALLLLP-----LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 488991141 419 TASLFALFlplgmahAAQYALWFNAVLCLGAMAVSALLL 457
Cdd:cd17325  344 GGFLYDAF-------GFATPFLAAAALLLLAAVLFLLLR 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-460 4.08e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 85.69  E-value: 4.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 176 siavallalfllrgtpesrsasasqhkldVGGLLSLIVALVLVnlfiskghgwgwssplsltmlagalaagtifirngmr 255
Cdd:COG2271  169 -----------------------------ILGLPGLLLALLRF------------------------------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 256 kgeaalidfalfrnrayGAAVLSNFLLNGAIGTMMI-ASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:COG2271  183 -----------------WLLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 335 RLPMMAGPVLTAIAIALISCTFLEKALyigVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAM 414
Cdd:COG2271  246 RRKLVLAIGLLLAALALLLLALLPSPA---LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL 322

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 488991141 415 GIAVTASLFALFlplgmahAAQYALWFNAVLCLGAMAVSALLLPRA 460
Cdd:COG2271  323 GPLLVGYLLDAT-------GYQAAFLLLAALALLAALLALLLLRET 361
MFS_1 pfam07690
Major Facilitator Superfamily;
17-415 2.05e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.15  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   17 LLVGIVLSVLTFWLFAqsvINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSA 96
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   97 MLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  177 iavallalfllrgtpesrsasasqhkldvgGLLSLIVALVLvnlfiskghgwgwssplsltmLAGALAAGTIFIRNGMRK 256
Cdd:pfam07690 158 ------------------------------AILSLLAAVLL---------------------LLPRPPPESKRPKPAEEA 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  257 GEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARL 336
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141  337 PMMAGpvLTAIAIALISCTFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:pfam07690 267 RLLLA--LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
18-418 2.57e-15

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 77.85  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  18 LVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAM 97
Cdd:PRK14995   8 LVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  98 LVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWY-EGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:PRK14995  88 AAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLIN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 177 I-AVALLALFLLRGTPesRSASASQHKLDVGGLLSLIVALVLVNLFISKG-HGWGWSSPLSLTMLAGALAAGtIFIRNGM 254
Cdd:PRK14995 168 VpIVLVVMGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTAlKGFLSLWVTSLTLLTGALLLG-LFIRTQL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 255 RkGEAALIDFALFRNRAYGAAV-LSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:PRK14995 245 A-ASRPMIDMRLFTHRIILSGVvMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 334 ARLPMMAGPVLTAIAIALISCTFLEKALYIGvvFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:PRK14995 324 LRLVATGGMALSALSFYGLAMTDFSTQQWQA--WGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAG 401


                 ....*
gi 488991141 414 MGIAV 418
Cdd:PRK14995 402 LGIAI 406
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 35-424 4.56e-15

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 76.06  E-value: 4.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  35 VINVVPAMISSLDiSLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQ 114
Cdd:cd17502   15 VATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 115 GLSAACIMPATLALIKTWYEGRARQRAVSFWViGSWGGSGLCS-FVGGAIATGLGWRWIFvfsiavallalfllrgtpes 193
Cdd:cd17502   94 GIGGGGLMSLAFIIIADLVPPRERGKYQGYIG-AVFGIASVAGpLIGGAFTDHLSWRWCF-------------------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 194 rsasasqhkldvggllslivalvLVNLFIskghgwgwssplsltmlaGALAAGTIfirngmrkgeaalidfalfrnRAYG 273
Cdd:cd17502  153 -----------------------YINLPI------------------GGLALALL---------------------RTIL 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 274 AAVLSNFLLNGAIGTMMIAS-IWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIALI 352
Cdd:cd17502  171 LSSIFGFLFGGALFGLIYYLpLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGL 250

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488991141 353 SCTFLEKALYIGVVFASnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFA 424
Cdd:cd17502  251 LTTLTLDTSKWLLIGYL-ILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLV 321
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-460 3.67e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 70.68  E-value: 3.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 176 siavallalfllrgtpesrsasasqhkldVGGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLagalaagtifirngmr 255
Cdd:COG2223  164 -----------------------------ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ---------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 256 kgeaalidFALFRNRAYGAAVLSNFLLNGA-IGTMMIASIWLQQGHHLTPLESGMMT-LGYLVTVLAMIrVGEKLLQRYG 333
Cdd:COG2223  199 --------LEALRDPRFWLLSLLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRP-LGGWLSDRIG 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 334 ARLPMMAGPVLTAIAIALISCTFLEKALYIGVVFAsnVLFGLGLGCYATPStdTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLL--LGLALGGGNGAVFA--LVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 488991141 414 MGIAVTASLFALFlplgmaHAAQYALWFNAVLCLGAMAVSALLLPRA 460
Cdd:COG2223  346 LGPLLFGALLDAT------GSYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 34-415 1.81e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 65.28  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  34 SVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVL 113
Cdd:cd17474   17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 114 QGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIAtGLGWRWIFVFSiavallalfllrgtpes 193
Cdd:cd17474   97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLL----------------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 194 rsasasqhkldvgGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIrngmrkgeaalidfalfrnrAYG 273
Cdd:cd17474  159 -------------AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLT--------------------FLV 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 274 AAVLSNFLLNGAIGTMmiaSIWLQQGHHLTPLESGMMTLGYLV-TVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIALi 352
Cdd:cd17474  206 SAFLYFFLYFAFLTYL---PFLLELLYGISPIIIGLLFAGWSVlLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLL- 281

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488991141 353 sctfLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:cd17474  282 ----LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 27-423 2.19e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 65.73  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  27 TFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGL 106
Cdd:cd06179    8 FAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 107 FLAGRVLQGLSAAC--IMPATLALIktwYEGRARQRAVSFWVIGSWGGSGLCSFVGGAI--ATGLGWRWIFVFSIAVALL 182
Cdd:cd06179   88 LIGGQALIGIGAGTqgLGAAVASEL---VPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNAL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 183 ALFLL--------RGTPESRSASASQHKLDVGGLLSLIVALVLVNLFISKGHG-WGWSSPLSLTMLAGALAAGTIFIRNG 253
Cdd:cd06179  165 ALILLfffyhpppRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNpYPWSSAHVIAPLVIGGVLLIAFGLYE 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 254 MR-KGEAALIDFALFRNRAYGAAVLSNFLlnGAIGTMMIASIWLQQGHHLT---PLESGMMTLG-YLVTVLAMIRVGeKL 328
Cdd:cd06179  245 WKgTKDGLLPPRLLFRGRNFALILIVAFV--EGMIFYSLNIFWPQQISLLFttdPLKAGLYQLPfGLGTLFGAILAG-LL 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 329 LQRYG-ARLPMMAGPVLTAIAIALIS-CTFLEKALyigvVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKM 406
Cdd:cd06179  322 LTKIKhIKWQLVAGFVLFTAFLALLAlITPDNKAL----AIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGS 397

                        410
                 ....*....|....*..
gi 488991141 407 GSSLGGAMGIAVTASLF 423
Cdd:cd06179  398 ARALGGAVGTAIFTSIL 414
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 21-175 8.23e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 63.36  E-value: 8.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVI--NVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAML 98
Cdd:cd17323    2 FIISFLTFVVTFGSSIysPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488991141  99 VVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF 158
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 21-175 1.46e-10

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 62.66  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYE-GRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17476   83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
17-175 1.59e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 62.58  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  17 LLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSA 96
Cdd:COG2807   19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141  97 MLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRaRQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:COG2807   99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 40-432 1.67e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.57  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  40 PAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17324   23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 120 CIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSiavallalfllrgtpesrsasas 199
Cdd:cd17324  103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI----------------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 200 qhkldvgGLLSLIVALVLVNLFiskghgwgwssPLSLTMLAGALAAGTIFirngmrkgeaalidFALFRNRAYGAAVLSN 279
Cdd:cd17324  160 -------AVLALLAALLLWRLL-----------PSLPPKKPGSLGLLSSL--------------LLLLRNPRLRLAYLIT 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 280 FLLNGAIGTMM--IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTAIAIALISCtfl 357
Cdd:cd17324  208 FLLFGGFFALYtyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG-RLADRGGRRALLIALLLLAAALLLLTLL--- 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488991141 358 ekALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVAS---GIYKMGSSLGGAMGIAVTASLFALFLPLGMA 432
Cdd:cd17324  284 --GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSlylAAYNLGGALGAALGGLVLDHGGWAGVGWVGA 359
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 21-457 2.29e-10

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 62.21  E-value: 2.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVIN-VVPAMISSLDISLETLT-LAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAML 98
Cdd:cd17473    3 TLLLASTLTVMAGAAIApALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  99 VVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATgLGWRWIFVFSIA 178
Cdd:cd17473   83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 179 VALLALFLLRGTPESRSASASQHKLDVGGLLSLIVALVLVNLFIskghgwgwssplsltMLAGALAAGTIFIRNGMrkge 258
Cdd:cd17473  162 ALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFL---------------AFLAMLLFYVIPIQLPF---- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 259 aalidfaLFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQqghhltplesgmmtlgylvtvlamirvgeKLLQRYGARLPM 338
Cdd:cd17473  223 -------LLQERGGGSAALIGLALAIASLAGAIGALLFG-----------------------------RLKRRLGKRRLL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 339 MAGPVLTAIAIALISCtflekALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLggamGIAV 418
Cdd:cd17473  267 AIGFALMALGFLLLAL-----ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL----GQFL 337

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 488991141 419 TASLFALFLPLGMAHAAQYALWfnAVLCLGAMAVSALLL 457
Cdd:cd17473  338 SPLVLGPLVNLTGGLSGAFLIL--GVLALVLAIVLLLLR 374
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 22-456 2.03e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 59.13  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  22 VLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVA 101
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 102 QGPGLFLAGRVLQGLSAAcIMPATLALIKTwYEGRARQRAVSFWVIGSWG-GSGLCSFVGGAIATGLGWRWIFVFSIava 180
Cdd:cd17504   82 PNLPVLIAGRALQGIGGA-VFPLAFALVRE-EFPPERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAA--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldvggllslIVALVLVNLfiskghgwgwssplsltmlagalaagtifirngmrkgeAA 260
Cdd:cd17504  157 -------------------------------PVAVLLAAL--------------------------------------VP 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 LIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQ-----GHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGAR 335
Cdd:cd17504  168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 336 LPMMAGPVLTAIAIALIsctfLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:cd17504  248 RVLLIGLVISAVGLLLL----ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 488991141 416 IAVTASLFALFLPLGMAH------AAQYALWFNAVLCLGAMAVSALL 456
Cdd:cd17504  324 PAIAGAILTTYTVSITSGgvptegAYVLAFLIGAALALAALLLSLLI 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 40-423 6.85e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.59  E-value: 6.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  40 PAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17320   23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 120 CIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFsiavallalfllrgtpesrsasas 199
Cdd:cd17320  103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF------------------------ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 200 qhkLDVGGLLSLIVALVLVNlfiskghgwgwssplsltmlagalaaGTIFIRNGMRKGEAALIDFA-LFRNRAYGAAVLS 278
Cdd:cd17320  159 ---LALLGLLLLLLVLLFLP--------------------------ETLPEEKRKPLLSSLLRAYKrVLKNRRFLGYALA 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 279 NFLLNGAI-GTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIALISCTFL 357
Cdd:cd17320  210 LGLSFAGLfAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAL 289

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488991141 358 EKALYIGVVFASNVLFGLGLGCyATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLF 423
Cdd:cd17320  290 LGGLSLWPLVAPLFLIFFGFGL-IFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
PRK10504 PRK10504
putative transporter; Provisional
 23-361 1.18e-08

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 57.05  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  23 LSVLTFWLFAQS-----VINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAM 97
Cdd:PRK10504  12 LWIVAFGFFMQSldttiVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  98 LVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSI 177
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 178 -AVALLALFLLRGTPesrSASASQHKLDVGGLLSLIVALVLVNLFISKGHGWGWSsPLSLTMLAGALAAGTIFIRNGMRK 256
Cdd:PRK10504 172 pVGIIGAIATLMLMP---NYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLS-PLAIAGLVAVGVVALLLYLLHARN 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 257 GEAALIDFALFRNRAYGAAVLSNFLlnGAIGTMMI---ASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:PRK10504 248 NNRALFSLKLFRTRTFSLGLAGSFA--GRIGSGMLpfmTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFG 325

                        330       340
                 ....*....|....*....|....*...
gi 488991141 334 ARLPMMAgpvlTAIAIALISCTFLEKAL 361
Cdd:PRK10504 326 YRRVLVA----TTLGLALVSLLFMLVAL 349
2_A_01_02 TIGR00880
Multidrug resistance protein;
71-175 3.29e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 52.27  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   71 SGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSW 150
Cdd:TIGR00880  18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97

                          90       100
                  ....*....|....*....|....*
gi 488991141  151 GGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:TIGR00880  98 LGPLLGPPLGGVLAQFLGWRAPFLF 122
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 40-175 1.08e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  40 PAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17319   27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488991141 120 CIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17319  107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 21-453 1.30e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAva 180
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 181 llalfllrgtpesrsasasqhkldvgGLLSLIVALVLvnlfiskghgWGWSSPLSLTMLAGALAAGTIFIRNGMRKgeaa 260
Cdd:cd06174  159 --------------------------AALALLAAILL----------LLVVPDPPESARAKNEEASSKSVLKLLKR---- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 261 lidfaLFRNRAYGAAVLSNFLLNGAIGTMMIASIW-LQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd06174  199 -----VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 340 agpvLTAIAIALISCTFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd06174  274 ----LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349

                        410       420       430
                 ....*....|....*....|....*....|....
gi 488991141 420 ASLFAlflplgMAHAAQYALWFNAVLCLGAMAVS 453
Cdd:cd06174  350 GFLLA------ATFGLTGAFLVLAVLLLLAAILL 377
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 21-218 2.55e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 2.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVA 180
Cdd:cd17489   81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 488991141 181 LLALFLLRGTPESRSASASQHKLDVGGLLSLIVALVLV 218
Cdd:cd17489  161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLP 198
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 38-175 1.64e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  38 VVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLS 117
Cdd:cd17365   21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488991141 118 AACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17365  101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 16-426 2.47e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.58  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:cd17355    3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  96 AMLVVAQGP-GLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFV 174
Cdd:cd17355   83 VLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 175 FsiavallalfllrgtpesrsasasqhkldVGGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAgtifirngm 254
Cdd:cd17355  163 V-----------------------------LALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLK--------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 255 rkgeaalidfALFRNRAYgAAVLSNFLLNGAIGTMMIAsiwlqqgHHLTPLESGMMTLGYLVTVLAMI--------RVGE 326
Cdd:cd17355  205 ----------EALRSASF-WLLALAFFLCGFAVVGLIV-------HLVPYLADRGISPAAAAVALALIglfnivgrLLSG 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 327 KLLQRYGARLPMMAGPVLTAIAIA-LISCTFLEKALYIGVVFasnvlFGLGLGCYATPSTDTAVANAPENKIGVASGIYK 405
Cdd:cd17355  267 WLGDRYSPRRLLAASYALRALGLAlLLLLPFPPLALLLFAAL-----FGLGWGATVPLTAALAARYFGARSYGTLFGLVF 341

                        410       420
                 ....*....|....*....|.
gi 488991141 406 MGSSLGGAMGIAVTASLFALF 426
Cdd:cd17355  342 APHQLGSALGPWLGGLLYDRT 362
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 38-177 3.76e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.75  E-value: 3.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  38 VVPAMISSLDISLETLTLAVSLSALFSGCFVVAS--GGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQG 115
Cdd:cd17316   21 VAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALlfGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488991141 116 LSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAI----ATGLGWRWIFVFSI 177
Cdd:cd17316  101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGA 166
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 47-322 5.37e-06

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 48.49  E-value: 5.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   47 DISLETLTLAVSLSALFSGCFV--VASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPA 124
Cdd:TIGR00893  23 DLGLSAAQYGYVFSAFSWGYVVgqFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  125 TLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSiavallalfllrgtpesrsasasqhkld 204
Cdd:TIGR00893 103 IILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE---------------------------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  205 vgGLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMRKGEAalIDFALFRNRAYGAAvLSNFLLNG 284
Cdd:TIGR00893 155 --GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQ--IKELLKDRRVWGLA-LGQFLVNI 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 488991141  285 AIGTMMI-ASIWLQQGHHLTPLESGMMT-LGYLVTVLAMI 322
Cdd:TIGR00893 230 GLGFFLTwFPTYLVQERGLSILEAGFMAsLPGIVGFIGMI 269
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
14-177 8.04e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 8.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  14 NDRLLVGIVLSVLTFWLFAQSVINV-VPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSI 92
Cdd:COG0738    5 NYRRALIAIYLLFFLWGFATALWGPlIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  93 VGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWI 172
Cdd:COG0738   85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWH 164


                 ....*
gi 488991141 173 FVFSI 177
Cdd:COG0738  165 LPYLI 169
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 38-215 9.37e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.68  E-value: 9.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  38 VVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLS 117
Cdd:cd17371   21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 118 AACIMPATLALIKTWYEGRARQRAV----SFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVALLALFLLRGTPES 193
Cdd:cd17371  101 FGGEWAAGAALMAEYVPARHRGKALgyvqSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEP 180

                        170       180
                 ....*....|....*....|..
gi 488991141 194 RSASASQHKLDVGGLLSLIVAL 215
Cdd:cd17371  181 PQWQAARAARRHFADRPSLREL 202
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 88-175 1.47e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 47.24  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  88 LGLSIVGSAMLVVAQGPGLfLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWvigsWGGSGLCSFVGGAIATGL 167
Cdd:cd17327   79 VLWGLLTLLTAAVKNFGGL-IALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFF----YAAAGLGSIFGGLLAYGV 153

                         90
                 ....*....|....*...
gi 488991141 168 ----------GWRWIFVF 175
Cdd:cd17327  154 fkilgvgglaGWRWLFII 171
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-155 2.81e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  11 FVGNDRLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGL 90
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488991141  91 SIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGL 155
Cdd:COG2814  283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
267-463 3.27e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.74  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 267 FRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTA 346
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 347 IAIALISCtflekALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF 426
Cdd:COG2814   87 LGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 488991141 427 lplgmahAAQYALWFNAVLCLGAMAVSALLLPRASHS 463
Cdd:COG2814  162 -------GWRWVFLVNAVLALLALLLLLRLLPESRPA 191
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 23-176 3.44e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.83  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   23 LSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQ 102
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488991141  103 GPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGS-WGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVP 156
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
268-460 4.17e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 4.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 268 RNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTA 346
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLfAIPVLVGALLRIPLG-FLVDRFGPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 347 IAIALISCtflekALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF 426
Cdd:COG2223   82 IGLLLLAL-----AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 488991141 427 lplgmahAAQYALWFNAVLCLGAMAVSALLLPRA 460
Cdd:COG2223  157 -------GWRNAFLILGILLLVVAVLAWLFLRDP 183
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 72-428 7.40e-05

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 44.99  E-value: 7.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  72 GGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQ-------GLSAACIM---------------PATLALI 129
Cdd:cd17322   58 AKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYnagytglNLLLTLILadfsslknrgfasaiPSLPYII 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 130 KTWYEGRARQRAV--SFWvigSWGgSGLCSFVGGAIATglgwrwIFVFSIAVA---LLALFLLRGTPESRSASASQ---- 200
Cdd:cd17322  138 TTWIGGNIAQAALpnSNW---RWG-YGMWAIILPLSSL------PLVLCLLYMqrkARKDGEIKELKNQETEEQTGglsq 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 201 ------HKLDVGG--LLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMRKGEAALIDFALFRNRAY 272
Cdd:cd17322  208 nlvklfWKLDIFGviLLTAGLGLILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTI 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 273 GAAVLSNFL--LNGAIGTMMIASIwLQQGHHLTPLESGMMTLGY-LVTVLAMIRVGekLLQRYGARLPM--MAGPVLTAI 347
Cdd:cd17322  288 LAACLIDFFyfFSYYIFSDYLYTV-LQVAVGESITSATRITNLYsFVSTVAGIFVG--FLIRKTRRYKVlvIIGVPLYIV 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 348 AIALIsCTFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALFL 427
Cdd:cd17322  365 GMGLL-IRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTL 443


                 .
gi 488991141 428 P 428
Cdd:cd17322  444 P 444
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 295-457 9.02e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 44.54  E-value: 9.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 295 WLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGEkLLQRYGARLPMMAGPVLTAIAIALISCTFlekalYIGVVFASNVLF 373
Cdd:cd17475   21 FLQEDLHLSLAQVGLLlSALNLGVAVSMLPAGW-LLDRFGERRVLAVGLLLMGAAALLMALVG-----SYPVLLVLLFLV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 374 GLGLGCyATPSTDTAVANA-PENKIGVASGIYKMGSSLGGAMGIavtaslfALFLPLGMAHAAQYALWFNAVLCLGAMAV 452
Cdd:cd17475   95 GAGYGS-VQPGGGRAIMRWfPPRERGLAMGIRQTGVPLGGALAA-------ALLPPLALHYGWRAAFVVAGLVSILAAVL 166


                 ....*
gi 488991141 453 SALLL 457
Cdd:cd17475  167 FWLFY 171
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 22-176 1.02e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 44.54  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  22 VLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMttIGLGLSIVGSAMLVVA 101
Cdd:cd17475    2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV--LAVGLLLMGAAALLMA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488991141 102 QGPG--LFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:cd17475   80 LVGSypVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVA 156
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 16-173 1.06e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.19  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  16 RLLVGIVLSVLTFWLFAQSVINVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGS 95
Cdd:cd17312    3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488991141  96 AMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIF 173
Cdd:cd17312   83 IFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 55-172 1.11e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.11  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  55 LAVSLSALFSGCFV--VASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTW 132
Cdd:cd17317   27 VALVQTIFFLGVLIgsLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 488991141 133 YEGRARQRAVS----FWVIGSWGGSGLCSFVGgaiatglGWRWI 172
Cdd:cd17317  107 VGPKYRSFVGIlfglFWALGYMLLALLAYLIR-------DWRWL 143
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 59-176 1.71e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 43.76  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  59 LSALFSGCFV--VASGGLADKFGRMRMttigLGLSIVGSAML-----VVAQ-GPGLFLAGRVLQGLSAACIMPATLALIK 130
Cdd:cd17318   62 LSSFFYGYILtqIPGGYLAEKYGAKRV----LGYSILITALLtlltpLAARgGYGALIVLRILQGLAQGVTFPAMHALWA 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 488991141 131 TWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:cd17318  138 KWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIF 183
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 54-176 2.16e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.38  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  54 TLAVSLSALFSGCFVVAS---GGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIK 130
Cdd:cd17328   34 SLAGLLQTVFIISYMVLSpifGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIA 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 488991141 131 TWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIAT-GLGWRWIFVFS 176
Cdd:cd17328  114 DLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVT 160
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 23-177 2.23e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.36  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  23 LSVLTFWLFAQSV-INVVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFG-RMRMTTIGLGLSIVGSAMLVV 100
Cdd:cd17490    2 LIIVFLFWFSQYVyVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMIL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488991141 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRArQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSI 177
Cdd:cd17490   82 FPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAA 157
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 51-176 2.98e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  51 ETLTLAVSLSALFSGcfvVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLS---AACIMPATLA 127
Cdd:cd17360   38 ELIVSSTVAGAAVGA---AIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgiASMTVPLYIA 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488991141 128 LIKTwyeGRARQRAVSFWVIGSWGGSGLCSFVGGAIA-TGLGWRWIFVFS 176
Cdd:cd17360  115 EAAP---PRIRGRLVTINVLFITGGQFVAYVINGAFSyLPGGWRWMLGLA 161
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
205-455 2.98e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 205 VGGLLSLIVALVLVNLFI-SKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMRKGEAALIDF----ALFRNRAYGAAVLSN 279
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGgDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkALLKNRPFLLLLLAY 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 280 FLLNGAIGTMMIASI-WLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIALIsctFLE 358
Cdd:COG2211  238 LLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 359 KALYIGVVFASNVLFGLGLGCYATPS----TDTAVANAPENKI---GVASGIYKMGSSLGGAMGIAVTASLFALF-LPLG 430
Cdd:COG2211  315 GPGNLWLLLVLAALAGIGLGAILVLPwamlADVVDYDEWKTGRrreGLYFGIFTFAIKLGQALAGALAGLLLALFgYVAG 394

                        250       260
                 ....*....|....*....|....*
gi 488991141 431 MAHAAQYALWFNAVLCLGAMAVSAL 455
Cdd:COG2211  395 AAQSPSALTGIRLLFFLLPAVLLLL 419
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 59-176 4.31e-04

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 42.42  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   59 LSALFSGCFV--VASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPG--LFLAGRVLQGLSAACIMPATLALIKTWYE 134
Cdd:TIGR00894  82 LSSHFYGQIIiqIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGiaLVVFCRVIQGLAQGSVSPATHKIIVKWAP 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488991141  135 GRARQRA-----------------VSFWVIGSWGGSGLCSFVGGAIATGLGWRWiFVFS 176
Cdd:TIGR00894 162 PKERSRLlgmstsgfqlgtfiflpISGWLCESWGGWPMIFYVFGIVGCAWSLLW-FVFP 219
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 71-415 5.24e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 42.34  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   71 SGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSW 150
Cdd:TIGR00895  72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  151 GGSGLCSFVGGAIATGLGWRWIFVF-SIAVALLALFLLRGTPESRSASASQHKLDVGGLLSLIVALVLVNlfiskghgwg 229
Cdd:TIGR00895 152 IGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAE---------- 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  230 wssPLSLTMLAGALAAGTIFIRNGMRKGEAALIDFALFrnRAYGAAVLSNFLLNGAIGTMMIasiwlQQGHHLTpLESGM 309
Cdd:TIGR00895 222 ---AQSALPEQKSTQGTKRSVFKALFQGKTARITVLLW--LLYFMLLVGVYFLTNWLPKLMV-----ELGFSLS-LAATG 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  310 MTLGYLVTVLAMIRVGeKLLQRYGARlPMMAGPVLTAIAIALISCTFLEKALYIGVVFASNVLFGLGLGCYATPSTDTAV 389
Cdd:TIGR00895 291 GALFNFGGVIGSIIFG-WLADRLGPR-VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYP 368

                         330       340
                  ....*....|....*....|....*.
gi 488991141  390 ANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:TIGR00895 369 TAIRATGVGWAIGIGRLGAIIGPILA 394
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 71-176 5.71e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 5.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  71 SGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSW 150
Cdd:cd17489  247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFD 326

                         90       100
                 ....*....|....*....|....*.
gi 488991141 151 GGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:cd17489  327 LGIGLGGLLLGLVAELFGYRAMFLLA 352
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 48-456 9.95e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 9.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  48 ISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLA 127
Cdd:cd17329   32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 128 LIKTWYEGRARQRAVSfwvIGSWGGSglCSFVGGAIATGlgwrWIFVFSIAVALLalfllrgtpesrsasasqhkldVGG 207
Cdd:cd17329  112 MIADVTTPENRTRAFS---LLYWAIN--LGVAIGPLLGG----LLLLYSFRLLFL----------------------AAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 208 LLSLIVALVLVNLfiskghgwgwsspLSLTMLAGALAAGTIFIRNGMRKgeaalidfalFRNRAYGAAVLSNFLLNGAIG 287
Cdd:cd17329  161 VLFLLAALVLLFL-------------LPETRPKRRAAEKTEILRGYKIV----------LRDRAFLLFLLASFLISLIYF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 288 TMMIA-SIWLQQGHHLTPLE-SGMMTLGYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTAIAIALISCtflekALYIGV 365
Cdd:cd17329  218 QLESTlPVYVVEILGLGESLlGLLLALNALLIVLLQFPVA-RLVERFRLRKILMIGILLFAIGFAVLAF-----ANTLAV 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 366 VFASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALFLPlgmahaaQYALWFNAVL 445
Cdd:cd17329  292 LILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP-------GLPWLILAAL 364

                        410
                 ....*....|.
gi 488991141 446 CLGAMAVSALL 456
Cdd:cd17329  365 GLIAAALLLGL 375
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
21-168 1.30e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVIN--VVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAML 98
Cdd:COG2211  232 LLLLAYLLFFLALALVAalLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488991141  99 VVAQG--PGLFLAGRVLQGLSAACIMPATLALI------KTWYEGRaRQRAVSFwvigswGGSGLCSFVGGAIATGLG 168
Cdd:COG2211  312 FFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTGR-RREGLYF------GIFTFAIKLGQALAGALA 382
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 21-175 1.56e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 40.62  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  21 IVLSVLTFWLFAQSVIN--VVPAMISSLDISLETLTLAvsLSALFSGCFV--VASGGLADKFGRMRMTTIGLGLSIVGSA 96
Cdd:cd17380    2 ILLFLATCICYADRVNMpiAIVPMAKEFGWSKTDQGLV--LSSFFWGYALtqVLGGYLADRFGGKKVLLLAVALWSLATL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  97 M--LVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFV 174
Cdd:cd17380   80 LtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159


                 .
gi 488991141 175 F 175
Cdd:cd17380  160 F 160
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-192 1.62e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  18 LVGIVLSVLTFWLFAQSVINVVPA-----------MISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTT- 85
Cdd:COG2271  172 LPGLLLALLRFWLLALAYFLVYFAlygfltwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVl 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  86 -IGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIA 164
Cdd:COG2271  252 aIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331

                        170       180       190
                 ....*....|....*....|....*....|..
gi 488991141 165 TGLGWRWIF----VFSIAVALLALFLLRGTPE 192
Cdd:COG2271  332 DATGYQAAFlllaALALLAALLALLLLRETRK 363
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 62-149 2.01e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 40.29  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  62 LFSGCFVVasGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRA 141
Cdd:cd17438   47 MMAGAFIW--GGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124

                         90
                 ....*....|..
gi 488991141 142 VS----FWVIGS 149
Cdd:cd17438  125 LSwlcmFWMIGG 136
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 34-194 3.16e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  34 SVINVVPAMIS-SLDISLETLTLAVSLSALFSGCFV--VASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAG 110
Cdd:cd17315   14 GVINGALLYIAkDLGFGLSTSLQGLVVSSLLLGAAIgsLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 111 RVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGL--GWRWIFVFSIAVALLALFLLR 188
Cdd:cd17315   94 RFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMF 173


                 ....*.
gi 488991141 189 GTPESR 194
Cdd:cd17315  174 FLPESR 179
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 207-456 4.78e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 207 GLLSLIVALVLVNLFISKGHGWGWSSPLSLTMLAGALAAGTIFIRNGMRKGEAALIDFALFRNRAYGAAVLSNFLLNGAI 286
Cdd:cd17335  135 GIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGH 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 287 GTMMIASIWLQQGHHLTP-LESGMMTLGYLVTVLAMIrVGEKLLQRYGARLPMMAGpvLTAIAIALISCTFLEKALYIGV 365
Cdd:cd17335  215 GLIYSFLFWHLQDLGGSKtLIGLLWTVGVVSEIPFFF-FSSRLIQRFGHVGLLYLG--LLAYVVRWLLYSFLENPWLVLP 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 366 VfasNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYK-MGSSLGGAMGIAVTASLFALFlplgmahAAQYALWFNAV 444
Cdd:cd17335  292 I---ELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQgLYFGLGGGLGSLIGGYLYEAF-------GARTTFRFFAI 361

                        250
                 ....*....|..
gi 488991141 445 LCLGAMAVSALL 456
Cdd:cd17335  362 AALAGLLAFFLI 373
emrD PRK11652
multidrug transporter EmrD;
72-203 6.49e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 38.73  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  72 GGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWG 151
Cdd:PRK11652  64 GPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILV 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488991141 152 GSGLCSFVGGAIATGLGWRWIFVF-SIAVALLALFLLRGTPESRSASASQHKL 203
Cdd:PRK11652 144 SPLLAPLIGGLLTTLFGWRACYLFlLLLGAGVTFSMARWMPETRPADARRTRV 196
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 72-172 8.20e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 38.80  E-value: 8.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141   72 GGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSfWVIGSWg 151
Cdd:TIGR01299 223 GGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLS-WLCMFW- 300

                          90       100
                  ....*....|....*....|.
gi 488991141  152 gsglcsFVGGAIATGLGWRWI 172
Cdd:TIGR01299 301 ------MIGGIYAAAMAWAII 315
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 38-223 8.33e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  38 VVPAMISSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLGLSIVGSAMLVVAQGPGLFLAGRVLQGLS 117
Cdd:cd17478   18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 118 AACIMPATLALIkTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIAT---GLGWRWIFVFSIAVALLALFLLRGTPESR 194
Cdd:cd17478   98 SAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAlfgGLGLLILLIIPGLAVALLLLRLRPLKKPE 176

                        170       180
                 ....*....|....*....|....*....
gi 488991141 195 SASASQHKLDVGGLLSLIVALVLVNLFIS 223
Cdd:cd17478  177 AKKAAAKSSARSTLKGVWRALLLLLIIVF 205
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 280-424 8.76e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.36  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141 280 FLLNGAIGTMMIASI---W------LQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIA 350
Cdd:cd17353    4 LVLLGAVLMHLILGYqyaWsvfnppLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488991141 351 LISCTflekALYIGVVFASNVLFGLGLG-CYATPsTDTAVANAPENKiGVASGIYKMGSSLGGAMGIAVTASLFA 424
Cdd:cd17353   84 LSAFA----ISLPLLFLGYGVLGGIGAGiGYITP-VSTAVKWFPDKR-GLATGIVIAGFGLGSLIFSPLIAYLIN 152
MFS_1 pfam07690
Major Facilitator Superfamily;
288-463 9.12e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 9.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  288 TMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIALISctfleKALYIGVVF 367
Cdd:pfam07690  15 LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL-----FASSLWLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  368 ASNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALFLPlgmahaaQYALWFNAVLCL 447
Cdd:pfam07690  90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW-------RAAFLILAILSL 162

                         170
                  ....*....|....*.
gi 488991141  448 GAMAVSALLLPRASHS 463
Cdd:pfam07690 163 LAAVLLLLPRPPPESK 178
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 11-174 9.87e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.98  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  11 FVGNDRLLVGIVLSVLTFWLFAQSVINVVPAMISS-LDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTIGLG 89
Cdd:cd06173  203 YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991141  90 LSIVGSAMLVVAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYEGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGW 169
Cdd:cd06173  283 LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362


                 ....*
gi 488991141 170 RWIFV 174
Cdd:cd06173  363 SAVFL 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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