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Conserved domains on  [gi|489000260|ref|WP_002910922|]
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MULTISPECIES: 23S rRNA (guanine(745)-N(1))-methyltransferase [Klebsiella]

Protein Classification

23S rRNA (guanine(745)-N(1))-methyltransferase( domain architecture ID 10793530)

23S rRNA (guanine(745)-N(1))-methyltransferase specifically methylates the guanosine in position 745 of 23S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 1-264 3.13e-170

23S rRNA methyltransferase A; Provisional


:

Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 470.55  E-value: 3.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   1 MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRH 80
Cdd:PRK11088   1 MSYQCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  81 Y---APTDLLDIGCGEGYYTHAFAAIASRS-----WGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYA 152
Cdd:PRK11088  81 RldeKATALLDIGCGEGYYTHALADALPEIttmqlFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 153 PCNAEELARVVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFA 232
Cdd:PRK11088 161 PCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEAEQLEGFELQHSERLAYPMRLTGSEAVALLQMTPFA 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489000260 233 WRAKAEVHAALRQQPTFGCQTDFMIHCWQREA 264
Cdd:PRK11088 241 WKATPEVKQQLAAKGVFSCETDFNIRVYRRSY 272
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 1-264 3.13e-170

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 470.55  E-value: 3.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   1 MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRH 80
Cdd:PRK11088   1 MSYQCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  81 Y---APTDLLDIGCGEGYYTHAFAAIASRS-----WGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYA 152
Cdd:PRK11088  81 RldeKATALLDIGCGEGYYTHALADALPEIttmqlFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 153 PCNAEELARVVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFA 232
Cdd:PRK11088 161 PCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEAEQLEGFELQHSERLAYPMRLTGSEAVALLQMTPFA 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489000260 233 WRAKAEVHAALRQQPTFGCQTDFMIHCWQREA 264
Cdd:PRK11088 241 WKATPEVKQQLAAKGVFSCETDFNIRVYRRSY 272
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 64-186 1.03e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  64 AGHYQpLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYP----QVNFCVASSQRLPF 139
Cdd:COG2226    5 AARYD-GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAeaglNVEFVVGDAEDLPF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489000260 140 SDASFDAVVRIYAPCNAE-------ELARVVRPGGWVITATPGPRHLLELKGLI 186
Cdd:COG2226   84 PDGSFDLVISSFVLHHLPdperalaEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-170 6.64e-19

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 78.86  E-value: 6.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   87 LDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYP--QVNFCVASSQRLPFSDASFDAVVRIYAPCNAE------- 157
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPreGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEdperalr 80

                          90
                  ....*....|...
gi 489000260  158 ELARVVRPGGWVI 170
Cdd:pfam08241  81 EIARVLKPGGILI 93
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 78-185 2.00e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 62.30  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   78 LRHYAPTDLLDIGCGEGYYTHAFAA--IASRSWGLDVSKPAIRAAAKRYP-QVNFCVASSQRLPFSDASFDAVVriyapC 154
Cdd:TIGR02072  30 KGIFIPASVLDIGCGTGYLTRALLKrfPQAEFIALDISAGMLAQAKTKLSeNVQFICGDAEKLPLEDSSFDLIV-----S 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 489000260  155 NA------------EELARVVRPGGWVITATPGPRHLLELKGL 185
Cdd:TIGR02072 105 NLalqwcddlsqalSELARVLKPGGLLAFSTFGPGTLHELRQS 147
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 85-171 8.32e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.74  E-value: 8.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  85 DLLDIGCGEGYYTHAFAAI-ASRSWGLDVSKPAI-----RAAAKRYPQVNFCVASSQRLPF-SDASFDAVVRIYA----- 152
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALelarkAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPlhhlv 80

                         90       100
                 ....*....|....*....|..
gi 489000260 153 ---PCNAEELARVVRPGGWVIT 171
Cdd:cd02440   81 edlARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 1-264 3.13e-170

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 470.55  E-value: 3.13e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   1 MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRH 80
Cdd:PRK11088   1 MSYQCPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  81 Y---APTDLLDIGCGEGYYTHAFAAIASRS-----WGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYA 152
Cdd:PRK11088  81 RldeKATALLDIGCGEGYYTHALADALPEIttmqlFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIYA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 153 PCNAEELARVVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFA 232
Cdd:PRK11088 161 PCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEAEQLEGFELQHSERLAYPMRLTGSEAVALLQMTPFA 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489000260 233 WRAKAEVHAALRQQPTFGCQTDFMIHCWQREA 264
Cdd:PRK11088 241 WKATPEVKQQLAAKGVFSCETDFNIRVYRRSY 272
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 64-186 1.03e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  64 AGHYQpLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYP----QVNFCVASSQRLPF 139
Cdd:COG2226    5 AARYD-GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAeaglNVEFVVGDAEDLPF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489000260 140 SDASFDAVVRIYAPCNAE-------ELARVVRPGGWVITATPGPRHLLELKGLI 186
Cdd:COG2226   84 PDGSFDLVISSFVLHHLPdperalaEIARVLKPGGRLVVVDFSPPDLAELEELL 137
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 63-174 5.39e-19

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 80.45  E-value: 5.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  63 DAGHYQPLRDAIAERLRHYAPTD--LLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVN--FCVASSQRLP 138
Cdd:COG2227    3 DPDARDFWDRRLAALLARLLPAGgrVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNvdFVQGDLEDLP 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489000260 139 FSDASFDAVV------RIYAPCNA-EELARVVRPGGWVITATP 174
Cdd:COG2227   83 LEDGSFDLVIcsevleHLPDPAALlRELARLLKPGGLLLLSTP 125
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-170 6.64e-19

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 78.86  E-value: 6.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   87 LDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYP--QVNFCVASSQRLPFSDASFDAVVRIYAPCNAE------- 157
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPreGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEdperalr 80

                          90
                  ....*....|...
gi 489000260  158 ELARVVRPGGWVI 170
Cdd:pfam08241  81 EIARVLKPGGILI 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-167 3.28e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 77.22  E-value: 3.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   87 LDIGCGEGYYTHAFAAIASRS-WGLDVSKPAIRAAAKRY----PQVNFCVASSQRLPFSDASFDAVVriyapCNA----- 156
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARvTGVDLSPEMLERARERAaeagLNVEFVQGDAEDLPFPDGSFDLVV-----SSGvlhhl 76

                          90       100
                  ....*....|....*....|
gi 489000260  157 ---------EELARVVRPGG 167
Cdd:pfam13649  77 pdpdleaalREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 87-174 8.72e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 68.81  E-value: 8.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  87 LDIGCGEGYYTHAFAAI---ASRSWGLDVSKPAIRAAAKRY----PQVNFCVASSQRLPFSDASFDAVV--RIYA----- 152
Cdd:PRK08317  24 LDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAaglgPNVEFVRGDADGLPFPDGSFDAVRsdRVLQhledp 103

                         90       100
                 ....*....|....*....|..
gi 489000260 153 PCNAEELARVVRPGGWVITATP 174
Cdd:PRK08317 104 ARALAEIARVLRPGGRVVVLDT 125
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
68-170 1.10e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 64.63  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  68 QPLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAV 147
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLADLAEPDGRFDLI 111

                         90       100       110
                 ....*....|....*....|....*....|
gi 489000260 148 ----VRIYAPCNAE---ELARVVRPGGWVI 170
Cdd:COG4976  112 vaadVLTYLGDLAAvfaGVARALKPGGLFI 141
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
82-170 1.21e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  82 APTDLLDIGCGEGYYTHAFAA--IASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFsDASFDAVVriyapCNA--- 156
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP-PEPFDLVV-----SNAalh 74

                         90       100
                 ....*....|....*....|...
gi 489000260 157 ---------EELARVVRPGGWVI 170
Cdd:COG4106   75 wlpdhaallARLAAALAPGGVLA 97
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 78-185 2.00e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 62.30  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   78 LRHYAPTDLLDIGCGEGYYTHAFAA--IASRSWGLDVSKPAIRAAAKRYP-QVNFCVASSQRLPFSDASFDAVVriyapC 154
Cdd:TIGR02072  30 KGIFIPASVLDIGCGTGYLTRALLKrfPQAEFIALDISAGMLAQAKTKLSeNVQFICGDAEKLPLEDSSFDLIV-----S 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 489000260  155 NA------------EELARVVRPGGWVITATPGPRHLLELKGL 185
Cdd:TIGR02072 105 NLalqwcddlsqalSELARVLKPGGLLAFSTFGPGTLHELRQS 147
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 85-171 8.32e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.74  E-value: 8.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  85 DLLDIGCGEGYYTHAFAAI-ASRSWGLDVSKPAI-----RAAAKRYPQVNFCVASSQRLPF-SDASFDAVVRIYA----- 152
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALelarkAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPlhhlv 80

                         90       100
                 ....*....|....*....|..
gi 489000260 153 ---PCNAEELARVVRPGGWVIT 171
Cdd:cd02440   81 edlARFLEEARRLLKPGGVLVL 102
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 71-167 1.09e-09

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 56.89  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   71 RDAIAERLRHYAPTDLLDIGCGEGYYTHAFA-AIASRSW--GLDVSKPAIRAAAKRYPQ---VNFCVASSQRLPFSDASF 144
Cdd:TIGR01934  28 RRRAVKLIGVFKGQKVLDVACGTGDLAIELAkSAPDRGKvtGVDFSSEMLEVAKKKSELplnIEFIQADAEALPFEDNSF 107

                          90       100       110
                  ....*....|....*....|....*....|
gi 489000260  145 DAVVRIYAPCNA-------EELARVVRPGG 167
Cdd:TIGR01934 108 DAVTIAFGLRNVtdiqkalREMYRVLKPGG 137
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 68-235 1.49e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.08  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  68 QPLRDAIAERLRHY-APTDLLDIGCGEGYYTHAFAA-IASRSWGLDVSKPAIRAAAKRYPQ-----VNFCVAS-SQRLPF 139
Cdd:COG0500   11 LPGLAALLALLERLpKGGRVLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARARAAKaglgnVEFLVADlAELDPL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 140 SDASFDAVVRIYA-----PCNA----EELARVVRPGGWVItatpgprhlleLKGLIYDEVRLHELKTEAMPGFRLEAQQQ 210
Cdd:COG0500   91 PAESFDLVVAFGVlhhlpPEEReallRELARALKPGGVLL-----------LSASDAAAALSLARLLLLATASLLELLLL 159

                        170       180
                 ....*....|....*....|....*
gi 489000260 211 LAYPMILTGSEAQALLQMTPFAWRA 235
Cdd:COG0500  160 LRLLALELYLRALLAAAATEDLRSD 184
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 86-167 2.30e-08

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 53.23  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  86 LLDIGCGEGYYTHAFAAIASRS---WGLDVSKPAIRAAAKRY------PQVNFCVASSQRLPFSDASFDA---------V 147
Cdd:PRK00216  55 VLDLACGTGDLAIALAKAVGKTgevVGLDFSEGMLAVGREKLrdlglsGNVEFVQGDAEALPFPDNSFDAvtiafglrnV 134

                         90       100
                 ....*....|....*....|.
gi 489000260 148 VRIYApcnA-EELARVVRPGG 167
Cdd:PRK00216 135 PDIDK---AlREMYRVLKPGG 152
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-169 2.50e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 50.44  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   87 LDIGCGEGYYTHAFAA--IASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDA------SFDAVVRIYAPCNAEE 158
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLgeldpgSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 489000260  159 -------LARVVRPGGWV 169
Cdd:pfam08242  81 pravlrnIRRLLKPGGVL 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 86-189 2.73e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 51.65  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   86 LLDIGCGEGYYTHAFAAIA---SRSWGLDVSKPAIRAAAKR-----YPQVNFCVASSQRLP--FSDASFDAVV------R 149
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgpnAEVVGIDISEEAIEKARENaqklgFDNVEFEQGDIEELPelLEDDKFDVVIsncvlnH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489000260  150 IYAPCNA-EELARVVRPGGWVITATpgPRHLLELKGLIYDE 189
Cdd:pfam13847  87 IPDPDKVlQEILRVLKPGGRLIISD--PDSLAELPAHVKED 125
PLN02244 PLN02244
tocopherol O-methyltransferase
 63-173 3.14e-06

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 47.43  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  63 DAGHYQPLRDAIAERLR--------HYAPTDLLDIGCGEG----YYTHAFAAIASrswGLDVSkP-------AIRAAAKR 123
Cdd:PLN02244  91 RGDHRQAQIRMIEESLAwagvpdddEKRPKRIVDVGCGIGgssrYLARKYGANVK---GITLS-PvqaaranALAAAQGL 166

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 124 YPQVNFCVASSQRLPFSDASFDAVvriYAPCNAE----------ELARVVRPGGWVITAT 173
Cdd:PLN02244 167 SDKVSFQVADALNQPFEDGQFDLV---WSMESGEhmpdkrkfvqELARVAAPGGRIIIVT 223
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 68-174 3.84e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 45.69  E-value: 3.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  68 QPLRDAIAERLRHyAPTD-LLDIGCGEGYYT-HAFAAIASRSWGLDVSKPAIRAAAKRY------PQVNFCVASSQRLPF 139
Cdd:COG2230   37 EAKLDLILRKLGL-KPGMrVLDIGCGWGGLAlYLARRYGVRVTGVTLSPEQLEYARERAaeaglaDRVEVRLADYRDLPA 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489000260 140 sDASFDAVVRI---------YAPCNAEELARVVRPGGWVITATP 174
Cdd:COG2230  116 -DGQFDAIVSIgmfehvgpeNYPAYFAKVARLLKPGGRLLLHTP 158
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
83-170 2.18e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.35  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   83 PTDLLDIGCGEGYYTHAFAAIASRSW---GLDVSKPAIRAAAKR-----YPQVNFCVASSQRLPFSDASFDAVVRIYAPC 154
Cdd:pfam01209  43 GNKFLDVAGGTGDWTFGLSDSAGSSGkvvGLDINENMLKEGEKKakeegKYNIEFLQGNAEELPFEDDSFDIVTISFGLR 122

                          90       100
                  ....*....|....*....|...
gi 489000260  155 NA-------EELARVVRPGGWVI 170
Cdd:pfam01209 123 NFpdylkvlKEAFRVLKPGGRVV 145
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 72-210 2.63e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 44.36  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  72 DAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIY 151
Cdd:PRK10258  32 DALLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDIESLPLATATFDLAWSNL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 152 AP--CNA-----EELARVVRPGGWVITATPGPRHLLELKG--------------LIYDEVRlhelktEAMPGFRLEAQQQ 210
Cdd:PRK10258 112 AVqwCGNlstalRELYRVVRPGGVVAFTTLVQGSLPELHQawqavderphanrfLPPDAIE------QALNGWRYQHHIQ 185
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 85-179 1.03e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 42.10  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  85 DLLDIGCGEGYYThafAAIASRS-----WGLDVSKPAIRAA---AKRY--PQVNFcVASSQRLPFSDASFDAVVriyapC 154
Cdd:COG2813   52 RVLDLGCGYGVIG---LALAKRNpearvTLVDVNARAVELAranAAANglENVEV-LWSDGLSGVPDGSFDLIL-----S 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489000260 155 N-------------AEEL----ARVVRPGG--WVITAtpgpRHL 179
Cdd:COG2813  123 NppfhagravdkevAHALiadaARHLRPGGelWLVAN----RHL 162
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 87-171 1.80e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 41.87  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   87 LDIGCGEGYYthAFAAI---ASRSWGLDVSKPAIRAA---AKRyPQVN--FCVASSQRLPfsDASFDAVVriyapCN--- 155
Cdd:pfam06325 166 LDVGCGSGIL--AIAALklgAKKVVGVDIDPVAVRAAkenAEL-NGVEarLEVYLPGDLP--KEKADVVV-----ANila 235

                          90       100
                  ....*....|....*....|..
gi 489000260  156 ------AEELARVVRPGGWVIT 171
Cdd:pfam06325 236 dplielAPDIYALVKPGGYLIL 257
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 70-185 3.95e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.10  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260   70 LRDAIAERL-RHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCvasSQRLPFSDASFDAVV 148
Cdd:pfam13489   9 LADLLLRLLpKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFD---EQEAAVPAGKFDVIV 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 489000260  149 RIYA-------PCNAEELARVVRPGGWVITATPGPRHLLELKGL 185
Cdd:pfam13489  86 AREVlehvpdpPALLRQIAALLKPGGLLLLSTPLASDEADRLLL 129
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
87-182 4.78e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 39.85  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  87 LDIGCG----EGYYthafaaiasrswGLDVSKpairaaakrYPQVNFCVASSQRLPFSDASFDAVV---------RIYAP 153
Cdd:COG4627    7 LNIGCGpkrlPGWL------------NVDIVP---------APGVDIVGDLTDPLPFPDNSVDAIYsshvlehldYEEAP 65

                         90       100
                 ....*....|....*....|....*....
gi 489000260 154 CNAEELARVVRPGGWVITATPGPRHLLEL 182
Cdd:COG4627   66 LALKECYRVLKPGGILRIVVPDLEHVARL 94
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 109-174 2.58e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 37.62  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260 109 GLDVSKPAIRAAAK-----RYPQVNFCVASSQRLPFSDASFDAVV-----------------RIYApcNA-EELARVVRP 165
Cdd:COG1041   53 GSDIDPKMVEGAREnlehyGYEDADVIRGDARDLPLADESVDAIVtdppygrsskisgeellELYE--KAlEEAARVLKP 130


                 ....*....
gi 489000260 166 GGWVITATP 174
Cdd:COG1041  131 GGRVVIVTP 139
PRK05785 PRK05785
hypothetical protein; Provisional
 71-164 2.59e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 38.13  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  71 RDAIAERLRHYA-PTDLLDIGCGEGYYTHAFAAIASR-SWGLDVSKPAIRAAAKRYPQVnfcVASSQRLPFSDASFDAVV 148
Cdd:PRK05785  39 AELVKTILKYCGrPKKVLDVAAGKGELSYHFKKVFKYyVVALDYAENMLKMNLVADDKV---VGSFEALPFRDKSFDVVM 115

                         90
                 ....*....|....*.
gi 489000260 149 RIYAPCNAEELARVVR 164
Cdd:PRK05785 116 SSFALHASDNIEKVIA 131
PRK06202 PRK06202
hypothetical protein; Provisional
 47-148 2.88e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 38.06  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  47 DPG-DSAEMMQARRAF-----LDAGHYQPLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSwGLDVSKPAI--- 117
Cdd:PRK06202  19 DPGcDPARLDRTYAGFrrvnrIVAGWRGLYRRLLRPALSADRPLTLLDIGCGGGDLAIDLARWARRD-GLRLEVTAIdpd 97

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489000260 118 -RAAA-----KRYPQVNFCVASSQRLPFSDASFDAVV 148
Cdd:PRK06202  98 pRAVAfaranPRRPGVTFRQAVSDELVAEGERFDVVT 134
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
 131-200 2.89e-03

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 38.83  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  131 VASSQRLPFSDASFDAV--VRIYAPCNAE------ELARVVRPGG-WVITATP-GPRHLLELKGlIYDEvrLHELkTEAM 200
Cdd:pfam03141 169 VLGTKRLPYPSRSFDLAhcSRCRIPWTANdgilllEVDRVLRPGGyFVLSGPPvYARTEEDLQE-IWKE--MEDL-TKSL 244
PLN02735 PLN02735
carbamoyl-phosphate synthase
 131-194 8.35e-03

carbamoyl-phosphate synthase


Pssm-ID: 215391 [Multi-domain]  Cd Length: 1102  Bit Score: 37.45  E-value: 8.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489000260  131 VASSQRLPFSDASFDAVVRIYAPcNAEELARVVRPGGWVITATPGPRHLLELKGLIYDEV-RLHE 194
Cdd:PLN02735  963 IAAGQRLPLSGTVFISLNDLTKP-HLVPIARGFLELGFRIVSTSGTAHFLELAGIPVERVlKLHE 1026
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
87-171 9.82e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 36.67  E-value: 9.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489000260  87 LDIGCGEGYYthAFAAI---ASRSWGLDVSKPAIRAA---AKRypqvNFcVASSQRLPFSDASFDAVVriyapCN----- 155
Cdd:PRK00517 124 LDVGCGSGIL--AIAAAklgAKKVLAVDIDPQAVEAArenAEL----NG-VELNVYLPQGDLKADVIV-----ANilanp 191

                         90       100
                 ....*....|....*....|
gi 489000260 156 ----AEELARVVRPGGWVIT 171
Cdd:PRK00517 192 llelAPDLARLLKPGGRLIL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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