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Conserved domains on  [gi|489003658|ref|WP_002914277|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Klebsiella]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 4.71e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 4.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003658  1 MTTPEDLQaragEAAALMKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYF 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGEL-CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 489003658 81 ITHPAVQQVINTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 4.71e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 4.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003658  1 MTTPEDLQaragEAAALMKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYF 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGEL-CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 489003658 81 ITHPAVQQVINTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 5.33e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 86.36  E-value: 5.33e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489003658 14 AAALMKAMSNPHRLLILCMLCDAPrASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 1.44e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 72.63  E-value: 1.44e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489003658   29 ILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVINTL 93
Cdd:smart00418  2 ILKLLAEGEL-CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 19-94 1.65e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 72.72  E-value: 1.65e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489003658 19 KAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITH-PAVQQVINTLK 94
Cdd:cd00090   2 KALSDPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESLL 77
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 1.27e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 56.68  E-value: 1.27e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489003658  23 NPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGEL-CVCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-96 2.92e-10

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 51.64  E-value: 2.92e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489003658 18 MKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVINTLKTL 96
Cdd:NF033789  2 FKALSDPTRREILELLKEGDM-TAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 27-71 6.40e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 39.65  E-value: 6.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489003658   27 LLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSE 71
Cdd:TIGR01884 146 LKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK 190
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 4.71e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.56  E-value: 4.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003658  1 MTTPEDLQaragEAAALMKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYF 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGEL-CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 489003658 81 ITHPAVQQVINTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 5.33e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 86.36  E-value: 5.33e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489003658 14 AAALMKAMSNPHRLLILCMLCDAPrASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 1.44e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 72.63  E-value: 1.44e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489003658   29 ILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVINTL 93
Cdd:smart00418  2 ILKLLAEGEL-CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 19-94 1.65e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 72.72  E-value: 1.65e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489003658 19 KAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITH-PAVQQVINTLK 94
Cdd:cd00090   2 KALSDPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESLL 77
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-85 3.64e-16

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 68.75  E-value: 3.64e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489003658  13 EAAALMKAMSNPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPA 85
Cdd:COG3398   86 EEKKILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPE 158
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
9-91 9.22e-14

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 61.59  E-value: 9.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003658   9 ARAGEAAALMKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERD-----AQRIHYFITH 83
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPA-YVSELARELGVSRQAVYKHLRKLEEAGLVESYREgredgRARKYYRLSA 80


                 ....*...
gi 489003658  84 PAVQQVIN 91
Cdd:COG1777   81 FRLEVTLT 88
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 1.27e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 56.68  E-value: 1.27e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489003658  23 NPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGEL-CVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
13-72 6.22e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 56.51  E-value: 6.22e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003658 13 EAAALMKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSER 72
Cdd:COG4189   8 ESLEVLKALASETRLRILRLLAEEPL-NVNELAEALGLPKSTVSYHIRKLEEAGLIRTEY 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-96 2.92e-10

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 51.64  E-value: 2.92e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489003658 18 MKAMSNPHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQVINTLKTL 96
Cdd:NF033789  2 FKALSDPTRREILELLKEGDM-TAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
26-68 1.92e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 48.58  E-value: 1.92e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489003658  26 RLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLI 68
Cdd:pfam13412  3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-73 2.63e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.38  E-value: 2.63e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489003658  19 KAMSNPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERD 73
Cdd:pfam12840  5 EALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-80 5.57e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 47.57  E-value: 5.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489003658  19 KAMSNPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYF 80
Cdd:COG3398   16 NVLDNDTRRRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRYF 77
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-75 1.32e-07

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 46.12  E-value: 1.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489003658  23 NPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQ 75
Cdd:COG1846   37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-74 2.42e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.73  E-value: 2.42e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489003658  23 NPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERDA 74
Cdd:pfam12802  4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSP 55
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 38-82 2.66e-07

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 44.13  E-value: 2.66e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 489003658 38 RASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFIT 82
Cdd:COG2512  30 RMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELP 74
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-73 9.51e-07

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 43.35  E-value: 9.51e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 489003658    23 NPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERD 73
Cdd:smart00347   9 TPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPS 59
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
29-72 3.79e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.99  E-value: 3.79e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489003658  29 ILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSER 72
Cdd:COG2345   18 ILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
29-68 4.52e-06

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 42.07  E-value: 4.52e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489003658  29 ILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLI 68
Cdd:COG1522   10 ILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVI 49
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-73 4.73e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 37.91  E-value: 4.73e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489003658  23 NPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSERD 73
Cdd:pfam01047  2 TLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 27-71 6.40e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 39.65  E-value: 6.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489003658   27 LLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSE 71
Cdd:TIGR01884 146 LKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQK 190
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 27-68 1.07e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 37.88  E-value: 1.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 489003658    27 LLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLI 68
Cdd:smart00344   6 RKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVI 47
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
26-90 1.15e-04

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 38.76  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489003658  26 RLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERDA-QRIHYFITHPAVQQVI 90
Cdd:COG1510   31 RIYALLYLSDEPL-TADELAEELGVSKSSVSTALRELEDWGLVRRVRKPgDRKDYFRAEKDVWELF 95
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
43-78 1.75e-04

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 35.88  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 489003658   43 ELARATGLSPSATSQHLARMRDEGLIDSERDAQRIH 78
Cdd:smart00419 13 EIAELLGLTRETVSRTLKRLEKEGLISREGGRIVIL 48
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
27-82 6.39e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 36.72  E-value: 6.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489003658  27 LLILCMLCDAPR-ASAGELARATGLSPSATSQHLARMRDEGLIdsERDAQRIHYFIT 82
Cdd:COG1414   12 LAILEALAEAGGgLSLSELARRLGLPKSTVHRLLATLEEEGYV--ERDPEGGRYRLG 66
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 43-68 6.51e-04

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.95  E-value: 6.51e-04
                        10        20
                ....*....|....*....|....*.
gi 489003658 43 ELARATGLSPSATSQHLARMRDEGLI 68
Cdd:cd00092  30 EIADYLGLTRETVSRTLKELEEEGLI 55
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 25-72 8.65e-04

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 35.99  E-value: 8.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 489003658   25 HRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSER 72
Cdd:pfam02082  10 HALLYLALHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR 57
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 23-71 1.04e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 36.20  E-value: 1.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489003658  23 NPHRLLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSE 71
Cdd:cd09655  138 SREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQK 186
DmsR COG3413
Predicted transcriptional regulator, contains HTH domain [General function prediction only];
35-61 1.51e-03

Predicted transcriptional regulator, contains HTH domain [General function prediction only];


Pssm-ID: 442639 [Multi-domain]  Cd Length: 143  Bit Score: 35.30  E-value: 1.51e-03
                         10        20
                 ....*....|....*....|....*...
gi 489003658  35 DAPR-ASAGELARATGLSPSATSQHLAR 61
Cdd:COG3413  104 EVPReATLEELAEELGISKSTLSEHLRR 131
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
24-73 1.51e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.03  E-value: 1.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489003658  24 PHRLLILCMLCDAPRaSAGELARATGLSPSATSQHLARMRDEGLIDSERD 73
Cdd:COG4742   16 EKRKNILLLLAEGPK-TRSELAESLDVSRSTILRQLKELEERGLIERDDG 64
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
39-73 2.81e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 34.41  E-value: 2.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489003658  39 ASAGELARATGLSPSATSQHLARMRDEGLIDSERD 73
Cdd:COG1321   25 VRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY 59
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
29-63 5.08e-03

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 31.96  E-value: 5.08e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489003658  29 ILCMLCDAPRASAGELARATGLSPSATSQHLARMR 63
Cdd:pfam13404  7 ILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
27-72 8.94e-03

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 33.27  E-value: 8.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489003658  27 LLILCMLCDAPRASAGELARATGLSPSATSQHLARMRDEGLIDSER 72
Cdd:COG1959   13 LLYLALHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVR 58
PaaX COG3327
DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation) [Transcription];
36-88 9.46e-03

DNA-binding transcriptional regulator PaaX (phenylacetic acid degradation) [Transcription];


Pssm-ID: 442556 [Multi-domain]  Cd Length: 281  Bit Score: 33.72  E-value: 9.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489003658  36 APRASAGELARATGLSPSATSQHLARMRDEGLIDSERDAQRIHYFITHPAVQQ 88
Cdd:COG3327   35 IWLGSLVRLLEPLGVSERAVRTALSRLVKRGWLESERRGRRSGYRLTPRGRRR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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