|
Name |
Accession |
Description |
Interval |
E-value |
| proX |
PRK11119 |
proline/glycine betaine ABC transporter substrate-binding protein ProX; |
19-332 |
0e+00 |
|
proline/glycine betaine ABC transporter substrate-binding protein ProX;
Pssm-ID: 236852 [Multi-domain] Cd Length: 331 Bit Score: 662.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 19 SAFAADLPGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAA 98
Cdd:PRK11119 18 QAFAADLPGKGITVQPAQSTIAEETFQTLLVSRALEKLGYDVNKPKEVDYNVFYTSIANGDATFTAVNWFPLHDDMYEAA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 99 GGDNKFYRKGVYVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIAKLFDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLS 178
Cdd:PRK11119 98 GGDKKFYREGVYVGGAAQGYLIDKKTADKYNITNIAQLKDPKIAKLFDTNGDGKADLTGCNPGWGCEAVINHQLKAYGLE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 179 KTVTHNQGNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGEQKNIDTKLANGANYGFPVNT 258
Cdd:PRK11119 178 DTVTHNQGNYAALMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGDQKNADTKLPNGKNYGFPVNT 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489003712 259 MHIVANKAWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADINGHVDGWIKAHQPLFDSWVKTALAAQQ 332
Cdd:PRK11119 258 MHIVANKAFAEKNPAAAKLFEIMKLPLADINAQNLRMHEGESSEADIERHVDGWIKAHQAQFDGWVKEARAAAK 331
|
|
| PBP2_EcProx_like |
cd13638 |
Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 ... |
26-324 |
0e+00 |
|
Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 periplasmic binding protein fold; This group includes the periplasmic substrate-binding protein ProX. ProX from the Escherichia coli ATP-binding cassette transport system ProU binds the compatible solutes glycine betaine and proline betaine with high affinity and specificity. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. The ProX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270356 [Multi-domain] Cd Length: 299 Bit Score: 535.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 26 PGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAGGDNKFY 105
Cdd:cd13638 1 PGKGVTVRPAKSTWAEEYFQTEIVSKGLEKLGYKVKEPKELDYPLFYVAVANGDADFWADHWFPLHDPFFEKAGGDAKLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 106 RKGVYVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIAKLFDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLSKTVTHNQ 185
Cdd:cd13638 81 RVGVIIGGGLQGYLIDKKTADAYNITSLDQLKDPKIAKLFDSDGDGKADLTGCNPGWGCEKVIEHQLDAYGLRDTVNHNQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 186 GNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGEQKNIDTKLANGANYGFPVNTMHIVANK 265
Cdd:cd13638 161 GSYSALMADAIARYKQGKPVLYYTWTPNWVSNVLVPGKDVVWLEVPFTALPGDQAGATTGVANGKNLGFPVNDIRIVANK 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 489003712 266 AWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADINGHVDGWIKAHQPLFDSWV 324
Cdd:cd13638 241 AFLEANPAAKKLFELVQIPLADISAQNLLMNQGEGSPEDIRRHADEWIAANQDTFDGWI 299
|
|
| ProX |
COG2113 |
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
20-329 |
3.27e-99 |
|
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 294.45 E-value: 3.27e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 20 AFAADLPGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEkPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAG 99
Cdd:COG2113 21 AAAAAAPGSCKTVTIADVGWTSATATTAVAKQILEELGYEVE-LVELDVPVTYQGLANGDIDVFLEAWLPTTHADYDEAY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 100 GDNKFYRKGVYVSGAAQGYLIDKKTAEqYHITSIDQLKDpqIAKLFDTnndgkaDLTGCTPGWGCEAVINHQIDAYGLSK 179
Cdd:COG2113 100 GDGKVEDLGTNYEGAKQGLAVPKYVAE-PGIKSIADLKK--YADLFDG------KIYGIEPGWGCNRVIEEAIKAYGLDD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 180 tVTHNQGNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQVPFSSLPGeqknidtklanganyGFPVNTM 259
Cdd:COG2113 171 -FELVEGSEAAMLAALARAYKRGEPIVFYGWTPHWMFAKY----DLKYLEDPKGAFGP---------------NFPAETV 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 260 HIVANKAWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADingHVDGWIKAHQPLFDSWVKTALA 329
Cdd:COG2113 231 HTVARKGFAEDNPEAAKLLENFKFTLEDINALMAAIENDGADPEE---AAKEWLKANPDVVDGWLPGVTA 297
|
|
| OpuAC |
pfam04069 |
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
31-315 |
3.26e-56 |
|
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 183.30 E-value: 3.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 31 TVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQP-LHDDMYAAAGGDNKFYRKGV 109
Cdd:pfam04069 2 TIVIGSKNWTEQEILANIAAQLLEALGYVVELVGLGSSAVLFAALASGDIDLYPEEWTGtTYEAYKKAVEEKLGLLVLGP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 110 YVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIaklfDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLSKtVTHNQGNYA 189
Cdd:pfam04069 82 LGAGNTYGLAVPKYVAEKPGIKSISDLAKPAD----DLELGFKGEFIGRPDGWGCMRSTEGLLKAYGLDK-YELVEGSEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 190 AMMADTIARYKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQvpfsslpgeqknidtklaNGANYGFPVNTMHIVANKAWAE 269
Cdd:pfam04069 157 AMDALIYAAYKRGEPDVVYAWTPDWMIKKY----DLVVLE------------------DPKGLFPPAYNVVPVVRKGFAE 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 489003712 270 KNPAAATLFSVMKLPIADINAENAMMHEGHASEADingHVDGWIKA 315
Cdd:pfam04069 215 KHPEVAAFLNKLSLDTEDLNELNAQVDVEGKDPEE---VAKDWLAE 257
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| proX |
PRK11119 |
proline/glycine betaine ABC transporter substrate-binding protein ProX; |
19-332 |
0e+00 |
|
proline/glycine betaine ABC transporter substrate-binding protein ProX;
Pssm-ID: 236852 [Multi-domain] Cd Length: 331 Bit Score: 662.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 19 SAFAADLPGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAA 98
Cdd:PRK11119 18 QAFAADLPGKGITVQPAQSTIAEETFQTLLVSRALEKLGYDVNKPKEVDYNVFYTSIANGDATFTAVNWFPLHDDMYEAA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 99 GGDNKFYRKGVYVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIAKLFDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLS 178
Cdd:PRK11119 98 GGDKKFYREGVYVGGAAQGYLIDKKTADKYNITNIAQLKDPKIAKLFDTNGDGKADLTGCNPGWGCEAVINHQLKAYGLE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 179 KTVTHNQGNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGEQKNIDTKLANGANYGFPVNT 258
Cdd:PRK11119 178 DTVTHNQGNYAALMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGDQKNADTKLPNGKNYGFPVNT 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489003712 259 MHIVANKAWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADINGHVDGWIKAHQPLFDSWVKTALAAQQ 332
Cdd:PRK11119 258 MHIVANKAFAEKNPAAAKLFEIMKLPLADINAQNLRMHEGESSEADIERHVDGWIKAHQAQFDGWVKEARAAAK 331
|
|
| PBP2_EcProx_like |
cd13638 |
Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 ... |
26-324 |
0e+00 |
|
Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 periplasmic binding protein fold; This group includes the periplasmic substrate-binding protein ProX. ProX from the Escherichia coli ATP-binding cassette transport system ProU binds the compatible solutes glycine betaine and proline betaine with high affinity and specificity. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. The ProX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270356 [Multi-domain] Cd Length: 299 Bit Score: 535.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 26 PGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAGGDNKFY 105
Cdd:cd13638 1 PGKGVTVRPAKSTWAEEYFQTEIVSKGLEKLGYKVKEPKELDYPLFYVAVANGDADFWADHWFPLHDPFFEKAGGDAKLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 106 RKGVYVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIAKLFDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLSKTVTHNQ 185
Cdd:cd13638 81 RVGVIIGGGLQGYLIDKKTADAYNITSLDQLKDPKIAKLFDSDGDGKADLTGCNPGWGCEKVIEHQLDAYGLRDTVNHNQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 186 GNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLKPGKDVVWLQVPFSSLPGEQKNIDTKLANGANYGFPVNTMHIVANK 265
Cdd:cd13638 161 GSYSALMADAIARYKQGKPVLYYTWTPNWVSNVLVPGKDVVWLEVPFTALPGDQAGATTGVANGKNLGFPVNDIRIVANK 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 489003712 266 AWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADINGHVDGWIKAHQPLFDSWV 324
Cdd:cd13638 241 AFLEANPAAKKLFELVQIPLADISAQNLLMNQGEGSPEDIRRHADEWIAANQDTFDGWI 299
|
|
| PBP2_Osm_BCP_like |
cd13535 |
Substrate binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
31-315 |
1.15e-103 |
|
Substrate binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system and related proteins; the type 2 periplasmic binding protein fold; This family is part of a high affinity multicomponent binding-protein-dependent ATP-binding cassette transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as betaines, choline, and L-proline. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270253 [Multi-domain] Cd Length: 277 Bit Score: 305.24 E-value: 1.15e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 31 TVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEvDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAGGDNKFYRKGVY 110
Cdd:cd13535 1 TVKLAVPSWTGETATTHVLGTILEALGYTVDYVSL-NNAVTFQSLANGDIDITVENWLPNHEDFYAKYVEGKKVVVLGQN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 111 VSGAAQGYLIDKKTAEQYHITSIDQLKDPQIAKLFDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLSKTVTHNQGNYAA 190
Cdd:cd13535 80 LYGAKQGFAVPKKVAELNPITNIADLGRPDAAALADSEGNGKGRLTGCPPGWGCEGAIEVKLEDYGLLKFVEVVPGSEGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 191 MMADTIARYKEGKPVLYYTWTPYWVsdvlKPGKDVVWLQVPFSSLPGEQKNIDTKLANGANYGFPVNTMHIVANKAWAEK 270
Cdd:cd13535 160 MTAAIKSAIKQGEPIFFYGWSPHWV----WFKFDVVYLSEPTYDEACYTMVQPWNEKSSVGCKFASSTVHIAVNKGLADE 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489003712 271 NPAAATLFSVMKLPIADINAENAMMHEGhasEADINGHVDGWIKA 315
Cdd:cd13535 236 NPAAAEILENFSLTVDDVNAFMGEISDN---GGDPEEAAAEWLKA 277
|
|
| ProX |
COG2113 |
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
20-329 |
3.27e-99 |
|
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 294.45 E-value: 3.27e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 20 AFAADLPGKGITVKPAQSTISEESFQTLLVSRALEKLGYTVEkPSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAG 99
Cdd:COG2113 21 AAAAAAPGSCKTVTIADVGWTSATATTAVAKQILEELGYEVE-LVELDVPVTYQGLANGDIDVFLEAWLPTTHADYDEAY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 100 GDNKFYRKGVYVSGAAQGYLIDKKTAEqYHITSIDQLKDpqIAKLFDTnndgkaDLTGCTPGWGCEAVINHQIDAYGLSK 179
Cdd:COG2113 100 GDGKVEDLGTNYEGAKQGLAVPKYVAE-PGIKSIADLKK--YADLFDG------KIYGIEPGWGCNRVIEEAIKAYGLDD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 180 tVTHNQGNYAAMMADTIARYKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQVPFSSLPGeqknidtklanganyGFPVNTM 259
Cdd:COG2113 171 -FELVEGSEAAMLAALARAYKRGEPIVFYGWTPHWMFAKY----DLKYLEDPKGAFGP---------------NFPAETV 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 260 HIVANKAWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADingHVDGWIKAHQPLFDSWVKTALA 329
Cdd:COG2113 231 HTVARKGFAEDNPEAAKLLENFKFTLEDINALMAAIENDGADPEE---AAKEWLKANPDVVDGWLPGVTA 297
|
|
| OpuAC |
pfam04069 |
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
31-315 |
3.26e-56 |
|
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 183.30 E-value: 3.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 31 TVKPAQSTISEESFQTLLVSRALEKLGYTVEKPSEVDYNVAYTSIAAGDTTFIATNWQP-LHDDMYAAAGGDNKFYRKGV 109
Cdd:pfam04069 2 TIVIGSKNWTEQEILANIAAQLLEALGYVVELVGLGSSAVLFAALASGDIDLYPEEWTGtTYEAYKKAVEEKLGLLVLGP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 110 YVSGAAQGYLIDKKTAEQYHITSIDQLKDPQIaklfDTNNDGKADLTGCTPGWGCEAVINHQIDAYGLSKtVTHNQGNYA 189
Cdd:pfam04069 82 LGAGNTYGLAVPKYVAEKPGIKSISDLAKPAD----DLELGFKGEFIGRPDGWGCMRSTEGLLKAYGLDK-YELVEGSEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 190 AMMADTIARYKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQvpfsslpgeqknidtklaNGANYGFPVNTMHIVANKAWAE 269
Cdd:pfam04069 157 AMDALIYAAYKRGEPDVVYAWTPDWMIKKY----DLVVLE------------------DPKGLFPPAYNVVPVVRKGFAE 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 489003712 270 KNPAAATLFSVMKLPIADINAENAMMHEGHASEADingHVDGWIKA 315
Cdd:pfam04069 215 KHPEVAAFLNKLSLDTEDLNELNAQVDVEGKDPEE---VAKDWLAE 257
|
|
| PBP2_BCP_1 |
cd13642 |
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
86-323 |
1.68e-22 |
|
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system-like; the type 2 periplasmic-binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270360 [Multi-domain] Cd Length: 292 Bit Score: 95.15 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 86 NWQPLHDDmYAAAGGDNKFYRKGVyvsGAAQGYLIDKKTAEQYHITSIDQLKDPQiAKLFDTNNDGKADLTGCTPGWGCE 165
Cdd:cd13642 62 NQQALWDK-YVTGGGTVALNPNPY---EGTQGICVPAATADKYGIKSDLDLTAPE-AALFDSDGDGKGEIWIGAPGWAST 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 166 AVINHQIDAYGLSKTVTHNQGNYAAMMADTIARYKEGKPVLYYTWTPYWV------------------SDVLKPGKDVVW 227
Cdd:cd13642 137 NIEQIKAKSYGYDETWELEEMSEAVFYAQLDAAYARGEPIVFYCYTPHWVfalydlvqleepaydaakWTTVLPTEDPDW 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 228 LqvpfsslpgEQKNIDTKlanganygFPVNTMHIVANKAWAEKNPAAATLFSVMKLPIADINA-ENAMMHEGHASEAdin 306
Cdd:cd13642 217 L---------EKSNAACA--------WADASVHIAYSASLEERAPEVAAFLSRIRLTPEEVNAmSYAVDVDGKDPAA--- 276
|
250
....*....|....*..
gi 489003712 307 gHVDGWIKAHQPLFDSW 323
Cdd:cd13642 277 -VAREWVAANADRVDEW 292
|
|
| PBP2_BCP_2 |
cd13643 |
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
49-323 |
9.27e-21 |
|
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system-like; the type 2 periplasmic-binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270361 [Multi-domain] Cd Length: 283 Bit Score: 90.43 E-value: 9.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 49 VSRALEKLGYTVEKPsEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAGGDNKFYRKGVYVSGAAQGYLIDKKTAEQY 128
Cdd:cd13643 19 AGYLLEKEGYKVEYV-TADEQAQWEALAAGDVDAQLEVWESSMGDKYEKALAAGSVVDLGDLGLIGREGWWYPKYVEELC 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 129 -HITSIDQLKDpqIAKLFDT-NNDGKADLTGCTPGWGCEAVInhQIDAYGLSKTVTHnQGNYAAMMADTIARYKEGKPVL 206
Cdd:cd13643 98 pGLPDWKALNK--CAALFATpETGPKGRLLGGPPDWGTNDAA--RIAALGLPFTVVP-AGSEAALWAELRAAYARKKPLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 207 YYTWTPYWVSDVLkpgkDVVWLQVPfsslPGEQKnIDTKLANGANY------GFPVNTMHIVANKAWAEKNPAAATLFSV 280
Cdd:cd13643 173 IYFWTPHWAFAKY----KGVFVELP----PYEEA-CETDPAWGNNPpakgdcGYPPGYLKKAAWAGFADKWPAAYELLKN 243
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489003712 281 MKLPIADINAENAMMHEGHASEADInghVDGWIKAHQPLFDSW 323
Cdd:cd13643 244 FTLTNEDQAAMAALIDVDGMSVEDA---AKKWLAANEATWKPW 283
|
|
| PBP2_OpuAC_like |
cd13639 |
Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; ... |
40-325 |
3.19e-18 |
|
Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; the type 2 periplasmic binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to betaine compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine and proline betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270357 [Multi-domain] Cd Length: 254 Bit Score: 82.58 E-value: 3.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 40 SEESFQTLLVSRALEKLGYTVEKpSEVDYNVAYTSIAAGDTTFIATNWQPLHDDMYAAAGGDnKFYRKGVYVSGAAQGYL 119
Cdd:cd13639 10 DEAIAVTNLAKAVLEEKGYDVEL-TQADAGPMYQGVASGDIDAFLDAWLPVTHKDYWDKYGD-DLEDLGPWYEGAKLGLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 120 IDKktaeqY-HITSIDQLKDpqIAKLFdtnnDGKadLTGCTPGWGCEAVINHQIDAYGLSKTVTHNqGNYAAMMADTIAR 198
Cdd:cd13639 88 VPS-----YvDIDSIEELLD--HADKF----GGK--IVGIEPGAGLMKLTEEAIEEYGLLDYELVT-SSTAAMLAELDRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 199 YKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQVPfsslpgeqKNIdtklanganYGfPVNTMHIVANKAWAEKNPAAATLF 278
Cdd:cd13639 154 IDNKEPIVVTGWSPHWMFAKY----DLKYLEDP--------KGV---------YG-EAESIHTIARKGFEEDHPEAYEFL 211
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 489003712 279 SVMKLPIADINA-ENAMMHEGHASEAdinghVDGWIKAHQPLFDSWVK 325
Cdd:cd13639 212 KNFKLTDEDLESlMLEIEDGGDPEEA-----AEEWIDENPDLVDEWLE 254
|
|
| PBP2_HisX_like |
cd13641 |
Substrate-binding domain of ABC-type histidine transporter involves in betaine and proline ... |
157-324 |
5.42e-18 |
|
Substrate-binding domain of ABC-type histidine transporter involves in betaine and proline uptake; the type 2 periplasmic-binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270359 [Multi-domain] Cd Length: 261 Bit Score: 82.30 E-value: 5.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 157 GCTPGWGCEAVINHQIDAYGLSKTVTH-NQGNYAAMMADTIARYKEGKPVLYYTWTPYWVSdvlkpGK-DVVWLQVPfss 234
Cdd:cd13641 101 NCPTGWGCEIINTNKLKAYGLDEGYTNfRPGSGAALDAAIASAYERGEPWVGYYWEPTWLM-----GKyDMTLLEEP--- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 235 lPGEQKNIDTKLANGANYG---FPVNTMHIVANKAWAEKNPAAATLFSVMKLPIADINAENAMMHEGHASEADinghVDG 311
Cdd:cd13641 173 -PYDEECWNCLCADCANPGacaFPSSTVTIAVNTDFAEKAPEIVEFLEKYETSLELTNEALAYMAENKASAEE----AAK 247
|
170
....*....|....
gi 489003712 312 W-IKAHQPLFDSWV 324
Cdd:cd13641 248 WfLKNHPDVWTQWV 261
|
|
| PBP2_ChoX |
cd13640 |
Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding ... |
45-325 |
7.69e-13 |
|
Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to choline and acetylcholine for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as choline and betaines. Choline is necessary for the biosynthesis of glycine betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. In the case of the Sinorhizobium meliloti choline uptake system ChoVWX, ChoV is the nucleotide-binding domain that provides energy for the transport process via ATP hydrolysis, ChoW is the integral transmembrane protein that forms the substrate translaocation pathway, and ChoX is the substrate-binding domain. ChoX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Pssm-ID: 270358 [Multi-domain] Cd Length: 266 Bit Score: 67.61 E-value: 7.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 45 QTLLVSRALEKLGYTVEKpSEVDYNVAYTSIAAGDT-TFIAtNWQPLHDDMYAAAGGDNKFYRKGVYVSGAAQGYLIDKK 123
Cdd:cd13640 15 TTAVASQILEALGYETEV-KELSVPIIYQGLANGDIdVFLG-NWMPSQEPMIDPYLEKGSIEVVGTNLEGAKYTLAVPTY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 124 TAEQyHITS---IDQLKDpqiaKLfdtnnDGKadLTGCTPGWGCEAVINHQI--DAYGLS--KTVthnQGNYAAMMADTI 196
Cdd:cd13640 93 VYEA-GVKSfadLAKFAD----KF-----DGK--IYGIEPGNDGNEIIQKMIdnNTYGLGdwKLV---ESSEQGMLAQVE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489003712 197 ARYKEGKPVLYYTWTPYWVSDVLkpgkDVVWLQvpfsslpgeqkniDTKLANGANYGfpVNTMHIVANKAWAEKNPAAAT 276
Cdd:cd13640 158 RAIRNKEWIVFLGWEPHPMNVEF----DIKYLD-------------GGDDYFGPNYG--AATVYTVTRKGYAEDCPNVAK 218
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489003712 277 LFSVMKLPIADinaENAMMHEGHASEADINGHVDGWIKAHQPLFDSWVK 325
Cdd:cd13640 219 LLSNLKFSVDM---ENQWMYEILNKGRDPEDAAREWIKANPDVVDAWLD 264
|
|
| |
