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Conserved domains on  [gi|489011961|ref|WP_002922496|]
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MULTISPECIES: glycosyltransferase family 4 protein [Klebsiella]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 5-371 8.03e-52

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 176.57  E-value: 8.03e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961   5 RLALVRQKYRPD-GGAERFVSRALEALDSSHLQLNVITREWQG--PVKPDWQIHICNPRKWGRISRERGFANAARALWQR 81
Cdd:cd03801    1 KILLLSPELPPPvGGAERHVRELARALAARGHDVTVLTPADPGepPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  82 ESFDLVQSHERIPGCDLYRAGDGVHRRWLQQRSRILPAWKSRLLfadRYHRYVMQAEREMYEDSHlrGVICNAEMIKREI 161
Cdd:cd03801   81 RKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLL---AAERRLLARAEALLRRAD--AVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 162 IEDFGLPAEKIHVIYNAIDNQRFLPPdeetfaaLRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIAP-----TDRYLLV 236
Cdd:cd03801  156 RALGGIPPEKIVVIPNGVDLERFSPP-------LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVI 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 237 VGKDKDQPRyQALAKSLNCEARVRFFGMQS--ETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIV 314
Cdd:cd03801  229 VGGDGPLRA-ELEELELGLGDRVRFLGFVPdeELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 315 DGHNGYVCDALDIPALQQAV-MALPARALGSAQGGHARERIMA-CTSERLSTQLLSLYQ 371
Cdd:cd03801  308 DGEGGLVVPPDDVEALADALlRLLADPELRARLGRAARERVAErFSWERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 5-371 8.03e-52

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 176.57  E-value: 8.03e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961   5 RLALVRQKYRPD-GGAERFVSRALEALDSSHLQLNVITREWQG--PVKPDWQIHICNPRKWGRISRERGFANAARALWQR 81
Cdd:cd03801    1 KILLLSPELPPPvGGAERHVRELARALAARGHDVTVLTPADPGepPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  82 ESFDLVQSHERIPGCDLYRAGDGVHRRWLQQRSRILPAWKSRLLfadRYHRYVMQAEREMYEDSHlrGVICNAEMIKREI 161
Cdd:cd03801   81 RKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLL---AAERRLLARAEALLRRAD--AVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 162 IEDFGLPAEKIHVIYNAIDNQRFLPPdeetfaaLRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIAP-----TDRYLLV 236
Cdd:cd03801  156 RALGGIPPEKIVVIPNGVDLERFSPP-------LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVI 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 237 VGKDKDQPRyQALAKSLNCEARVRFFGMQS--ETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIV 314
Cdd:cd03801  229 VGGDGPLRA-ELEELELGLGDRVRFLGFVPdeELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 315 DGHNGYVCDALDIPALQQAV-MALPARALGSAQGGHARERIMA-CTSERLSTQLLSLYQ 371
Cdd:cd03801  308 DGEGGLVVPPDDVEALADALlRLLADPELRARLGRAARERVAErFSWERVAERLLDLYR 366
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
208-337 5.89e-28

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 106.44  E-value: 5.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  208 LIYVGS-GFERKG---LAAAIRAIAPTDRY--LLVVGkDKDQPRYQALAKSLncEARVRFFGMQSETLPFYQMADGLLLP 281
Cdd:pfam13692   4 ILFVGRlHPNVKGvdyLLEAVPLLRKRDNDvrLVIVG-DGPEEELEELAAGL--EDRVIFTGFVEDLAELLAAADVFVLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489011961  282 TLYDPFPNVILEAMACGLPVITTTgCGGAEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:pfam13692  81 SLYEGFGLKLLEAMAAGLPVVATD-VGGIPELVDGENGLLVPPGDPEALAEAILRL 135
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 271-375 2.49e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 91.21  E-value: 2.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 271 FYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMALPA-RALGSAQGGH 349
Cdd:COG0438   17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEdPELRRRLGEA 96

                         90       100
                 ....*....|....*....|....*..
gi 489011961 350 ARERIMA-CTSERLSTQLLSLYQDLVK 375
Cdd:COG0438   97 ARERAEErFSWEAIAERLLALYEELLA 123
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 161-374 6.76e-19

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 87.09  E-value: 6.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  161 IIEDFGLPAEKIHVIYNAIDNQRFLPPDEETFAALRAKWQLPLQATCLIyVGSGFERKGLAAAIRAIAPTDRY------- 233
Cdd:TIGR03088 151 LRGPVKVPPAKIHQIYNGVDTERFHPSRGDRSPILPPDFFADESVVVGT-VGRLQAVKDQPTLVRAFALLVRQlpegaer 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  234 --LLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAE 311
Cdd:TIGR03088 230 lrLVIVGDGPARGACEQMVRAAGLAHLVWLPGERDDVPALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPE 309

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489011961  312 FIVDGHNGYVCDALDIPALQQAVMA-LPARALGSAQGGHARERIMACTS-ERLSTQLLSLYQDLV 374
Cdd:TIGR03088 310 LVQHGVTGALVPPGDAVALARALQPyVSDPAARRAHGAAGRARAEQQFSiNAMVAAYAGLYDQLL 374
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
142-332 2.39e-15

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 76.29  E-value: 2.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 142 YEDSHLrgVICNAemIKREIIeDFGLPAEKIHVIYNAIDNQRFLPPDEETFAALRakwqlplqatcLIYVGS-GFE-RKG 219
Cdd:PRK09922 133 CADYHL--AISSG--IKEQMM-ARGISAQRISVIYNPVEIKTIIIPPPERDKPAV-----------FLYVGRlKFEgQKN 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 220 LAAAIRAIAPT--DRYLLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQM----ADGLLLPTLYDPFPNVILE 293
Cdd:PRK09922 197 VKELFDGLSQTtgEWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPWEVVQQkiknVSALLLTSKFEGFPMTLLE 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489011961 294 AMACGLPVITTTG-CGGAEFIVDGHNGYVCDALDIPALQQ 332
Cdd:PRK09922 277 AMSYGIPCISSDCmSGPRDIIKPGLNGELYTPGNIDEFVG 316
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 162-373 2.02e-08

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 55.71  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 162 IEDfGLPAEKIHVIYNAIDNQRFlppdeetfAALRAKWQL-PLQATCLIyvGSGFERKGLAAAIRAIAPTDRYL-----L 235
Cdd:NF038011 273 IAD-GAPPERTRVIPNGIDLPRL--------APLRAQRPAgIPPVVGLI--GRVVPIKDIKTFIRAMRTVVRAMpeaegW 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 236 VVGKDKDQPRY----QALAKSLNCEARVRFFGMQ--SETLPfyQMadGLL-LPTLYDPFPNVILEAMACGLPVITT-TGC 307
Cdd:NF038011 342 IVGPEEEDPAYaaecRSLVASLGLQDKVKFLGFQkiDDLLP--QV--GLMvLSSISEALPLVVLEAFAAGVPVVTTdVGS 417

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489011961 308 -------GGAEFIVDGHNGYVCDALDIPALQQAVMALparaLGSAQGGHARERIMACTSERLSTQ--LLSLYQDL 373
Cdd:NF038011 418 crqliegLDEEDRALGAAGEVVAIADPQALARAALDL----LRDPQRWQAAQAAGLARVERYYTEelMFDRYREL 488
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 5-371 8.03e-52

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 176.57  E-value: 8.03e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961   5 RLALVRQKYRPD-GGAERFVSRALEALDSSHLQLNVITREWQG--PVKPDWQIHICNPRKWGRISRERGFANAARALWQR 81
Cdd:cd03801    1 KILLLSPELPPPvGGAERHVRELARALAARGHDVTVLTPADPGepPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  82 ESFDLVQSHERIPGCDLYRAGDGVHRRWLQQRSRILPAWKSRLLfadRYHRYVMQAEREMYEDSHlrGVICNAEMIKREI 161
Cdd:cd03801   81 RKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLL---AAERRLLARAEALLRRAD--AVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 162 IEDFGLPAEKIHVIYNAIDNQRFLPPdeetfaaLRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIAP-----TDRYLLV 236
Cdd:cd03801  156 RALGGIPPEKIVVIPNGVDLERFSPP-------LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKllrrgPDVRLVI 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 237 VGKDKDQPRyQALAKSLNCEARVRFFGMQS--ETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIV 314
Cdd:cd03801  229 VGGDGPLRA-ELEELELGLGDRVRFLGFVPdeELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 315 DGHNGYVCDALDIPALQQAV-MALPARALGSAQGGHARERIMA-CTSERLSTQLLSLYQ 371
Cdd:cd03801  308 DGEGGLVVPPDDVEALADALlRLLADPELRARLGRAARERVAErFSWERVAERLLDLYR 366
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 17-337 5.57e-44

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 155.59  E-value: 5.57e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  17 GGAERFVSRALEALDSSHLQLNVITREWQGPVKPDWQIHICNPRKWGRISRERGFANAARALWQR-----ESFDLVQSHe 91
Cdd:cd03811   12 GGAERVLLNLANALDKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLKAILKLKrilkrAKPDVVISF- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  92 RIPGCDLYRAGDGVHRRWLQQR----SRILPAWKSRLLFADRYHRYvmqaeremyedshlRGVICNAEMIKREIIEDFGL 167
Cdd:cd03811   91 LGFATYIVAKLAAARSKVIAWIhsslSKLYYLKKKLLLKLKLYKKA--------------DKIVCVSKGIKEDLIRLGPS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 168 PAEKIHVIYNAIDNQRFLPPDEEtfaalrAKWQLPLQATCLIYVGSGFERKGLAAAIRAIA-----PTDRYLLVVGKDKD 242
Cdd:cd03811  157 PPEKIEVIYNPIDIDRIRALAKE------PILNEPEDGPVILAVGRLDPQKGHDLLIEAFAklrkkYPDVKLVILGDGPL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 243 QPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTgCGGA-EFIVDGHNGYV 321
Cdd:cd03811  231 REELEKLAKELGLAERVIFLGFQSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTD-CPGPrEILDDGENGLL 309

                        330
                 ....*....|....*.
gi 489011961 322 CDALDIPALQQAVMAL 337
Cdd:cd03811  310 VPDGDAAALAGILAAL 325
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 15-370 1.14e-35

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 133.60  E-value: 1.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  15 PDGGAERFVSRALEALDSS---HLQLNVITREWQGPVKPDWQIHI-----CNPRKWGRISRergfanaARALWQRESFDL 86
Cdd:cd03807   10 NVGGAETMLLRLLEHMDKSrfeHVVISLTGDGVLGEELLAAGVPVvclglSSGKDPGVLLR-------LAKLIRKRNPDV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  87 VQSHerIPGCDLYRA----GDGVHRRWLQQRSRILPAWKSRLLFADRYHRYVMQaeremyedshlRGVICNAEMIKREII 162
Cdd:cd03807   83 VHTW--MYHADLIGGlaakLAGGVKVIWSVRSSNIPQRLTRLVRKLCLLLSKFS-----------PATVANSSAVAEFHQ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 163 EDfGLPAEKIHVIYNAIDNQRFLPPDEETfAALRAKWQLPLQATCLIYVGSGFERKGLAAAIRA---IAPT--DRYLLVV 237
Cdd:cd03807  150 EQ-GYAKNKIVVIYNGIDLFKLSPDDASR-ARARRRLGLAEDRRVIGIVGRLHPVKDHSDLLRAaalLVEThpDLRLLLV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 238 GKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTgCGGAEFIVDGH 317
Cdd:cd03807  228 GRGPERPNLERLLLELGLEDRVHLLGERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATD-VGGAAELVDDG 306

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489011961 318 NGYVCDALDIPALQQAVMALPARALGSAQ-GGHARERIMA-CTSERLSTQLLSLY 370
Cdd:cd03807  307 TGFLVPAGDPQALADAIRALLEDPEKRARlGRAARERIANeFSIDAMVRRYETLY 361
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 17-373 3.64e-34

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 129.81  E-value: 3.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  17 GGAERFVSRALEALDSSHLQLNVITRE----WQGPVKPDWQIHICNPR--------KWGRISRERGFANAARALW---QR 81
Cdd:cd03798   14 PGRGIFVRRQVRALSRRGVDVEVLAPApwgpAAARLLRKLLGEAVPPRdgrrllplKPRLRLLAPLRAPSLAKLLkrrRR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  82 ESFDLVQSHeripgcDLYRAGDG--VHRRWLQQRSrILPAWKSRLLFADRYHRYVMQaerEMYEDSHLRGVICNAEMIKR 159
Cdd:cd03798   94 GPPDLIHAH------FAYPAGFAaaLLARLYGVPY-VVTEHGSDINVFPPRSLLRKL---LRWALRRAARVIAVSKALAE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 160 EIIEdFGLPAEKIHVIYNAIDNQRFLPPDEETfaalrakwQLPLQATCLIYVGSGFERKGLAAAIRAIAPTDRY-----L 234
Cdd:cd03798  164 ELVA-LGVPRDRVDVIPNGVDPARFQPEDRGL--------GLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKArpdvvL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 235 LVVGKDKDQPRYQALAKSLNCEARVRFFGmqseTLPFYQMA------DGLLLPTLYDPFPNVILEAMACGLPVITTTgCG 308
Cdd:cd03798  235 LIVGDGPLREALRALAEDLGLGDRVTFTG----RLPHEQVPayyracDVFVLPSRHEGFGLVLLEAMACGLPVVATD-VG 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489011961 309 G-AEFIVDGHNGYVCDALDIPALQQAVMALPARALGSAQGGHARERIMACTSERLSTQ-LLSLYQDL 373
Cdd:cd03798  310 GiPEVVGDPETGLLVPPGDADALAAALRRALAEPYLRELGEAARARVAERFSWVKAADrIAAAYRDV 376
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 119-323 7.20e-29

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 115.07  E-value: 7.20e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 119 AWKSRLLFADRYHRYVmqaeREMYEdsHLRGVICNAEMIKREIIEdFGLpAEKIHVIYNAIDNQRFLPPDEEtfaALRAK 198
Cdd:cd03817  126 IPKGKLLVKAVVRKLV----RRFYN--HTDAVIAPSEKIKDTLRE-YGV-KGPIEVIPNGIDLDKFEKPLNT---EERRK 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 199 WQLPLQATCLIYVGS-GFErKGLAAAIRAIAPTDR----YLLVVGKDKDQPRYQALAKSLNCEARVRFFGM--QSETLPF 271
Cdd:cd03817  195 LGLPPDEPILLYVGRlAKE-KNIDFLLRAFAELKKepniKLVIVGDGPEREELKELARELGLADKVIFTGFvpREELPEY 273

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489011961 272 YQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCD 323
Cdd:cd03817  274 YKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFE 325
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
208-337 5.89e-28

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 106.44  E-value: 5.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  208 LIYVGS-GFERKG---LAAAIRAIAPTDRY--LLVVGkDKDQPRYQALAKSLncEARVRFFGMQSETLPFYQMADGLLLP 281
Cdd:pfam13692   4 ILFVGRlHPNVKGvdyLLEAVPLLRKRDNDvrLVIVG-DGPEEELEELAAGL--EDRVIFTGFVEDLAELLAAADVFVLP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489011961  282 TLYDPFPNVILEAMACGLPVITTTgCGGAEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:pfam13692  81 SLYEGFGLKLLEAMAAGLPVVATD-VGGIPELVDGENGLLVPPGDPEALAEAILRL 135
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 139-373 9.53e-27

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 109.34  E-value: 9.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 139 REMYEDSHLRGVICN---AEMIKREiiedFGLPAEKIHVIYNAIDNQRFLPPDEetfAALRAKWQLPLQATCLIYVGSGF 215
Cdd:cd03825  131 REALAKKRLTIVAPSrwlADMVRRS----PLLKGLPVVVIPNGIDTEIFAPVDK---AKARKRLGIPQDKKVILFGAESV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 216 E--RKG---LAAAIRAIAPTDRYLLVVGKDKDQPRYQAlakslncEARVRFFGM---QSETLPFYQMADGLLLPTLYDPF 287
Cdd:cd03825  204 TkpRKGfdeLIEALKLLATKDDLLLVVFGKNDPQIVIL-------PFDIISLGYiddDEQLVDIYSAADLFVHPSLADNL 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 288 PNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQA---VMALPARALGSAQggHARERIMACTSERL-S 363
Cdd:cd03825  277 PNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGDVQALAEAiewLLANPKERESLGE--RARALAENHFDQRVqA 354

                        250
                 ....*....|
gi 489011961 364 TQLLSLYQDL 373
Cdd:cd03825  355 QRYLELYKDL 364
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 17-367 1.04e-26

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 108.60  E-value: 1.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  17 GGAERFV---SRALEALDSSHLQLNVITREWQgPVKPDWQIHICNPRKWGRISRERGFAnaaRALWQRESFDLVQSHERI 93
Cdd:cd03819   11 GGAETYIldlARALAERGHRVLVVTAGGPLLP-RLRQIGIGLPGLKVPLLRALLGNVRL---ARLIRRERIDLIHAHSRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  94 PGcdlyRAGdgvhrrWLQQRSRILPawksrllFADRYH--RYVMQAEREMYEDSHLRG--VICNAEMIKREIIEDFGLPA 169
Cdd:cd03819   87 PA----WLG------WLASRLTGVP-------LVTTVHgsYLATYHPKDFALAVRARGdrVIAVSELVRDHLIEALGVDP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 170 EKIHVIYNAIDNQRFLPpdeETFAALRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIA----PTDRYLLVVGKDKDQPR 245
Cdd:cd03819  150 ERIRVIPNGVDTDRFPP---EAEAEERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAelkdEPDFRLLVAGDGPERDE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 246 YQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDAL 325
Cdd:cd03819  227 IRRLVERLGLRDRVTFTGFREDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPG 306

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 489011961 326 DIPALQQAVMALPARAlgsaqggHARERIMACTSERLSTQLL 367
Cdd:cd03819  307 DAEALADAIRAAKLLP-------EAREKLQAAAALTEAVREL 341
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 208-337 1.04e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 101.20  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  208 LIYVGSGFERKGLAAAIRAIA-----PTDRYLLVVGKDKDQPRYQALAKSLNCEARVRFFGMQS-ETLP-FYQMADGLLL 280
Cdd:pfam00534   5 ILFVGRLEPEKGLDLLIKAFAllkekNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSdEDLPeLLKIADVFVL 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489011961  281 PTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:pfam00534  85 PSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKL 141
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 115-319 1.19e-25

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 106.29  E-value: 1.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 115 RILPAWKSRLLFADRYHRYVMQAEREmyedshlRGVICNAEMIKREIIEDFGLPAEKIHVIYNAIDNQRFLPPDEEtfaA 194
Cdd:cd03809  114 LRYPEFFPKRFRLYYRLLLPISLRRA-------DAIITVSEATRDDIIKFYGVPPEKIVVIPLGVDPSFFPPESAA---V 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 195 LRAKWQLPlqATCLIYVGSGFERKGLAAAIRA--IAPTDRY---LLVVG-KDKDQPRYQALAKSLNCEARVRFFGMQS-E 267
Cdd:cd03809  184 LIAKYLLP--EPYFLYVGTLEPRKNHERLLKAfaLLKKQGGdlkLVIVGgKGWEDEELLDLVKKLGLGGRVRFLGYVSdE 261

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 268 TLP-FYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTG------CGGAEFIVDGHNG 319
Cdd:cd03809  262 DLPaLYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNIsvlpevAGDAALYFDPLDP 320
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 117-368 1.08e-23

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 101.16  E-value: 1.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 117 LPAWK-SRLLFADRYHRYV-MQAEREMYEDSHLrgVICNAEMIKREIIEDFGLPAEKIHVIYNAIDNQRFLPPDEEtfAA 194
Cdd:cd03800  134 LGRVKyRHLGAQDTYHPSLrITAEEQILEAADR--VIASTPQEADELISLYGADPSRINVVPPGVDLERFFPVDRA--EA 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 195 LRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIA--PTDRY---LLVVG------KDKDQPRYQALAKSLNCEARVRFFG 263
Cdd:cd03800  210 RRARLLLPPDKPVVLALGRLDPRKGIDTLVRAFAqlPELRElanLVLVGgpsddpLSMDREELAELAEELGLIDRVRFPG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 264 M--QSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMALPA-R 340
Cdd:cd03800  290 RvsRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPHDPEALAAALRRLLDdP 369

                        250       260
                 ....*....|....*....|....*....
gi 489011961 341 ALGSAQGGHARERIMAC-TSERLSTQLLS 368
Cdd:cd03800  370 ALWQRLSRAGLERARAHyTWESVADQLLT 398
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 150-330 8.71e-23

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 98.05  E-value: 8.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 150 VICNAEMIKREIIEDFGLPAEKIHVIYNAIDNQRFLPPDEEtfaalrakwQLPLQATCLIYVGSGFERKGLAAAIRAIA- 228
Cdd:cd03808  143 VIFVNEDDRDLAIKKGIIKKKKTVLIPGSGVDLDRFQYSPE---------SLPSEKVVFLFVARLLKDKGIDELIEAAKi 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 229 PTDRY----LLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITT 304
Cdd:cd03808  214 LKKKGpnvrFLLVGDGELENPSEILIEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITT 293

                        170       180
                 ....*....|....*....|....*...
gi 489011961 305 --TGCggAEFIVDGHNGYVCDALDIPAL 330
Cdd:cd03808  294 dvPGC--RELVIDGVNGFLVPPGDVEAL 319
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 149-373 2.34e-22

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 97.04  E-value: 2.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 149 GVICNAEMIKREIIEDFGlPAEKIHVIYNAIDNQRFLPpdEETFAALRAKWQLPLQATcLIYVgSGFER-KGLAAAIRAI 227
Cdd:cd04962  144 RVTAVSSSLRQETYELFD-VDKDIEVIHNFIDEDVFKR--KPAGALKRRLLAPPDEKV-VIHV-SNFRPvKRIDDVVRVF 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 228 APTDR----YLLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVIT 303
Cdd:cd04962  219 ARVRRkipaKLLLVGDGPERVPAEELARELGVEDRVLFLGKQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVS 298

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489011961 304 TTGCGGAEFIVDGHNGYVCDALDIPAL-QQAVMALPARALGSAQGGHARERIMA-CTSERLSTQLLSLYQDL 373
Cdd:cd04962  299 SNAGGIPEVVKHGETGFLSDVGDVDAMaKSALSILEDDELYNRMGRAARKRAAErFDPERIVPQYEAYYRRL 370
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 271-375 2.49e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 91.21  E-value: 2.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 271 FYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMALPA-RALGSAQGGH 349
Cdd:COG0438   17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEdPELRRRLGEA 96

                         90       100
                 ....*....|....*....|....*..
gi 489011961 350 ARERIMA-CTSERLSTQLLSLYQDLVK 375
Cdd:COG0438   97 ARERAEErFSWEAIAERLLALYEELLA 123
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 145-365 6.51e-22

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 95.60  E-value: 6.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 145 SHLRGVICNAEMIKREIIEdFGLPAEKIHVIYNAIDNQRFLPPDEetfaalrakwqlPLQATCLIYVGSGFERKGLAAAI 224
Cdd:cd05844  142 RPAALFVAVSGFIRDRLLA-RGLPAERIHVHYIGIDPAKFAPRDP------------AERAPTILFVGRLVEKKGCDVLI 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 225 RAIA------PTDRyLLVVGKDKDQPRYQALAKSLnceARVRFFGMQS--ETLPFYQMADGLLLPTLYDP------FPNV 290
Cdd:cd05844  209 EAFRrlaarhPTAR-LVIAGDGPLRPALQALAAAL---GRVRFLGALPhaEVQDWMRRAEIFCLPSVTAAsgdsegLGIV 284

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489011961 291 ILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMALPA-RALGSAQGGHAREriMACTSERLSTQ 365
Cdd:cd05844  285 LLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGDVDALADALQALLAdRALADRMGGAARA--FVCEQFDIRVQ 358
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 158-337 4.70e-21

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 93.07  E-value: 4.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 158 KREIIEDFGLPAEKIHVIYNAIDnqrflPPDEETFAALRAKwqlplqatCLIYVGS-----GFERkgLAAAIRAIAptDR 232
Cdd:cd03820  147 EADKLKKYKQPNSNVVVIPNPLS-----FPSEEPSTNLKSK--------RILAVGRltyqkGFDL--LIEAWALIA--KK 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 233 Y----LLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCG 308
Cdd:cd03820  210 HpdwkLRIYGDGPEREELEKLIDKLGLEDRVKLLGPTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPT 289

                        170       180       190
                 ....*....|....*....|....*....|
gi 489011961 309 G-AEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:cd03820  290 GpSEIIEDGENGLLVPNGDVDALAEALLRL 319
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 117-367 1.19e-20

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 92.41  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 117 LPAWKSRLLFadRYHRYVmqaEREMYEDSHlrGVICNAEMIKREIIeDFGLPAEKIHVIYNAIDNQRFLPPDEETfaaLR 196
Cdd:cd03794  141 LGVLKKGSLL--KLLKKL---ERKLYRLAD--AIIVLSPGLKEYLL-RKGVPKEKIIVIPNWADLEEFKPPPKDE---LR 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 197 AKWQLPlQATCLIYVGS-GFERkGLAAAIRAIA----PTDRYLLVVGKDKDQPRYQALAKSLNCEaRVRFFGMQS--ETL 269
Cdd:cd03794  210 KKLGLD-DKFVVVYAGNiGKAQ-GLETLLEAAErlkrRPDIRFLFVGDGDEKERLKELAKARGLD-NVTFLGRVPkeEVP 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 270 PFYQMADGLLLP----TLYDP-FPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMALPA-RALG 343
Cdd:cd03794  287 ELLSAADVGLVPlkdnPANRGsSPSKLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPGDPEALADAILELLDdPELR 366

                        250       260
                 ....*....|....*....|....*
gi 489011961 344 SAQGGHARERIMA-CTSERLSTQLL 367
Cdd:cd03794  367 RAMGENGRELAEEkFSREKLADRLL 391
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 99-322 6.47e-20

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 87.46  E-value: 6.47e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  99 YRAGDGVHRRWLQQRSRILPAWKSRL-LFADRYHRYVMQAEREMYEDSHLrgVICNaEMIKREIIEDFGLPAEKIHVIYN 177
Cdd:cd01635    8 YPPLRGGLELHVRALARALAALGHEVtVLALLLLALRRILKKLLELKPDV--VHAH-SPHAAALAALLAARLLGIPIVVT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 178 AIDNQRFLPPDEETFAALRAKWQLPLqaTCLIYVGSGFERKGLAAAIRAIA-----PTDRYLLVVGKDKDQPRYQALAKS 252
Cdd:cd01635   85 VHGPDSLESTRSELLALARLLVSLPL--ADKVSVGRLVPEKGIDLLLEALAllkarLPDLVLVLVGGGGEREEEEALAAA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489011961 253 LNCEARVRFFGMQSETLP---FYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVC 322
Cdd:cd01635  163 LGLLERVVIIGGLVDDEVlelLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 136-356 1.97e-19

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 88.58  E-value: 1.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 136 QAEREMYEDSHL---RGVICNAEMIKREIiEDFGLPaEKIHVIYNAIDNQRFLPPDEETfaalRAKWQLPlQATCLIYVG 212
Cdd:cd03821  139 RIALHLIERRNLnnaALVHFTSEQEADEL-RRFGLE-PPIAVIPNGVDIPEFDPGLRDR----RKHNGLE-DRRIILFLG 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 213 SGFERKGLAAAIRAIAP-----TDRYLLVVGKDKDQPRY-QALAKSLNCEARVRFFGM--QSETLPFYQMADGLLLPTLY 284
Cdd:cd03821  212 RIHPKKGLDLLIRAARKlaeqgRDWHLVIAGPDDGAYPAfLQLQSSLGLGDRVTFTGPlyGEAKWALYASADLFVLPSYS 291

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489011961 285 DPFPNVILEAMACGLPVITTTGCGGAEFIVDGhNGYVCDaLDIPALqqavmalpARALGSAQGGHARERIMA 356
Cdd:cd03821  292 ENFGNVVAEALACGLPVVITDKCGLSELVEAG-CGVVVD-PNVSSL--------AEALAEALRDPADRKRLG 353
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 161-374 6.76e-19

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 87.09  E-value: 6.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  161 IIEDFGLPAEKIHVIYNAIDNQRFLPPDEETFAALRAKWQLPLQATCLIyVGSGFERKGLAAAIRAIAPTDRY------- 233
Cdd:TIGR03088 151 LRGPVKVPPAKIHQIYNGVDTERFHPSRGDRSPILPPDFFADESVVVGT-VGRLQAVKDQPTLVRAFALLVRQlpegaer 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  234 --LLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAE 311
Cdd:TIGR03088 230 lrLVIVGDGPARGACEQMVRAAGLAHLVWLPGERDDVPALMQALDLFVLPSLAEGISNTILEAMASGLPVIATAVGGNPE 309

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489011961  312 FIVDGHNGYVCDALDIPALQQAVMA-LPARALGSAQGGHARERIMACTS-ERLSTQLLSLYQDLV 374
Cdd:TIGR03088 310 LVQHGVTGALVPPGDAVALARALQPyVSDPAARRAHGAAGRARAEQQFSiNAMVAAYAGLYDQLL 374
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 150-372 9.61e-18

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 83.53  E-value: 9.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 150 VICNAEMIKReIIEDFGLPAEKIHVIYNAIdnqRFLPPDEETFAALRAKwqlplqaTCLIYVGSGFERKGLAAAIRAIAP 229
Cdd:cd03823  147 VLAPSRFTAN-LHEANGLFSARISVIPNAV---EPDLAPPPRRRPGTER-------LRFGYIGRLTEEKGIDLLVEAFKR 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 230 TDRY---LLVVGKDKDQPRYQALAkslncEARVRFFG-MQSETLP-FYQMADGLLLPTL-YDPFPNVILEAMACGLPVIT 303
Cdd:cd03823  216 LPREdieLVIAGHGPLSDERQIEG-----GRRIAFLGrVPTDDIKdFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIA 290

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489011961 304 TTGCGGAEFIVDGHNGYVCDALDIPALQQAVM------ALPARAlgsaqGGHARERImacTSERLSTQLLSLYQD 372
Cdd:cd03823  291 SDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRrlltdpALLERL-----RAGAEPPR---STESQAEEYLKLYRD 357
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 106-370 6.69e-17

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 81.19  E-value: 6.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 106 HRRWLQQRSRILPAWKSRLLFA--DRYHRyvmqaeremyedsHLRGVICNAEMIKREIIedfGLPAEKIHVIYNAIDNQR 183
Cdd:cd03814  116 HTDFPEYLSYYTLGPLSWLAWAylRWFHN-------------PFDTTLVPSPSIARELE---GHGFERVRLWPRGVDTEL 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 184 FLPpdEETFAALRAKWqLPLQATCLIYVGSGFERKGLAAAIRAIAPTDRY----LLVVGkdkDQPRYQALAKSLNCearV 259
Cdd:cd03814  180 FHP--SRRDAALRRRL-GPPGRPLLLYVGRLAPEKNLEALLDADLPLAASppvrLVVVG---DGPARAELEARGPD---V 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 260 RFFGMQ-SETLP-FYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:cd03814  251 IFTGFLtGEELArAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAAAFAAALRAL 330

                        250       260       270
                 ....*....|....*....|....*....|....
gi 489011961 338 PA-RALGSAQGGHARERIMACTSERLSTQLLSLY 370
Cdd:cd03814  331 LEdPELRRRMAARARAEAERYSWEAFLDNLLDYY 364
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
17-180 4.54e-16

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 75.26  E-value: 4.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961   17 GGAERFVSRALEALDSSHLQLNVITREWQGPVKPDW----QIHICNPRKWGRISRERGFANAARALWQRESFDLVQSHER 92
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVvrvvRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERPDVVHAHSP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961   93 IPgcdlyrAGDGVHRRWLQQRSRI-------LPAWKSRLLFADRYHRYVMQAEREMYEDSHLrgVICNAEMIKREIIEDF 165
Cdd:pfam13439  81 FP------LGLAALAARLRLGIPLvvtyhglFPDYKRLGARLSPLRRLLRRLERRLLRRADR--VIAVSEAVADELRRLY 152

                         170
                  ....*....|....*
gi 489011961  166 GLPAEKIHVIYNAID 180
Cdd:pfam13439 153 GVPPEKIRVIPNGVD 167
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 166-373 1.40e-15

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 76.94  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 166 GLPAEKIHVIYNAIDNQRFLP-PDEETFAAlrakwqlplqatcliYVGSGFERKGLAAAIRAIAPTDRYLLVVGKDKDQP 244
Cdd:cd03802  144 TPPIDYLTVVHNGLDPADYRFqPDPEDYLA---------------FLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDED 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 245 RYQALAKSLNCEaRVRFFGM--QSETLPFYQMADGLLLPTLYD-PFPNVILEAMACGLPVItTTGCGG-AEFIVDGHNGY 320
Cdd:cd03802  209 YFYYLQEPLPGP-RIEFIGEvgHDEKQELLGGARALLFPINWDePFGLVMIEAMACGTPVI-AYRRGGlPEVIQHGETGF 286

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 321 VCDALDipALQQAVMALPA------RAlgsaqggHARERImacTSERLSTQLLSLYQDL 373
Cdd:cd03802  287 LVDSVE--EMAEAIANIDRidraacRR-------YAEDRF---SAARMADRYEALYRKV 333
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
142-332 2.39e-15

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 76.29  E-value: 2.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 142 YEDSHLrgVICNAemIKREIIeDFGLPAEKIHVIYNAIDNQRFLPPDEETFAALRakwqlplqatcLIYVGS-GFE-RKG 219
Cdd:PRK09922 133 CADYHL--AISSG--IKEQMM-ARGISAQRISVIYNPVEIKTIIIPPPERDKPAV-----------FLYVGRlKFEgQKN 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 220 LAAAIRAIAPT--DRYLLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQM----ADGLLLPTLYDPFPNVILE 293
Cdd:PRK09922 197 VKELFDGLSQTtgEWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPWEVVQQkiknVSALLLTSKFEGFPMTLLE 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489011961 294 AMACGLPVITTTG-CGGAEFIVDGHNGYVCDALDIPALQQ 332
Cdd:PRK09922 277 AMSYGIPCISSDCmSGPRDIIKPGLNGELYTPGNIDEFVG 316
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 153-354 3.88e-14

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 72.87  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 153 NAEMIKREIIEdFGLPAEKIHVIYNAIDNQRFlppdeeTFAALRAKWQLPLQatcLIYVGSGFERKGLAAAIRAIA---- 228
Cdd:cd03799  132 NCELFKHRLIA-LGCDEKKIIVHRSGIDCNKF------RFKPRYLPLDGKIR---ILTVGRLTEKKGLEYAIEAVAklaq 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 229 --PTDRYLlVVGKDKDQPRYQALAKSLNCEARVRFFGM--QSETLPFYQMADGLLLPTL------YDPFPNVILEAMACG 298
Cdd:cd03799  202 kyPNIEYQ-IIGDGDLKEQLQQLIQELNIGDCVKLLGWkpQEEIIEILDEADIFIAPSVtaadgdQDGPPNTLKEAMAMG 280

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489011961 299 LPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMAL-PARALGSAQGGHARERI 354
Cdd:cd03799  281 LPVISTEHGGIPELVEDGVSGFLVPERDAEAIAEKLTYLiEHPAIWPEMGKAGRARV 337
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 159-356 4.80e-14

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 73.14  E-value: 4.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 159 REIIEDFGLPAEKIHVIYNAIDNQRFLPPDEEtfaalRAKWQLPLqatcLIYVGSGFERKGLAAAIRAIA------PTDR 232
Cdd:cd03813  256 RRRQIRLGADPDKTRVIPNGIDIQRFAPAREE-----RPEKEPPV----VGLVGRVVPIKDVKTFIRAFKlvrramPDAE 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 233 yLLVVGKDKDQPRYQA----LAKSLNCEARVRFFGMQS--ETLPFYQMadgLLLPTLYDPFPNVILEAMACGLPVITTTG 306
Cdd:cd03813  327 -GWLIGPEDEDPEYAQeckrLVASLGLENKVKFLGFQNikEYYPKLGL---LVLTSISEGQPLVILEAMASGVPVVATDV 402

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 307 CGGAEFIVDGHNGYVCDALDIP-----ALQQAVMAL---PAR--ALGSAqgghARERIMA 356
Cdd:cd03813  403 GSCRELIYGADDALGQAGLVVPpadpeALAEALIKLlrdPELrqAFGEA----GRKRVEK 458
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 13-337 2.84e-13

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 70.00  E-value: 2.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  13 YRPD-GGAERFVSRALEALDSSHLQLNVIT--REWQGPVKPDWQIHICNPRKWGRISRERGFANAARALWQ-RESFDLVQ 88
Cdd:cd03795    9 YYPDiGGIEQVIYDLAEGLKKKGIEVDVLCfsKEKETPEKEENGIRIHRVKSFLNVASTPFSPSYIKRFKKlAKEYDIIH 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  89 SHERIPGCDLYRAGDGVHRRW-LQQRSRILPAWKSRLLFADRYHRYVMQAERemyedshlrgVICNAEMIKR--EIIEDF 165
Cdd:cd03795   89 YHFPNPLADLLLFFSGAKKPVvVHWHSDIVKQKKLLKLYKPLMTRFLRRADR----------IIATSPNYVEtsPTLREF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 166 glpAEKIHVIYNAIDNQRFLPPDEETFAALRAKWQLPLqatcLIYVGSGFERKGLAAAIRAIAPTDRYLLVVGKDKDQPR 245
Cdd:cd03795  159 ---KNKVRVIPLGIDKNVYNIPRVDFENIKREKKGKKI----FLFIGRLVYYKGLDYLIEAAQYLNYPIVIGGEGPLKPD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 246 YQALAKsLNCEARVRFFGMQS--ETLPFYQMADGLLLP--TLYDPFPNVILEAMACGLPVITTTGCGGAEFIV-DGHNGY 320
Cdd:cd03795  232 LEAQIE-LNLLDNVKFLGRVDdeEKVIYLHLCDVFVFPsvLRSEAFGIVLLEAMMCGKPVISTNIGTGVPYVNnNGETGL 310

                        330
                 ....*....|....*..
gi 489011961 321 VCDALDIPALQQAVMAL 337
Cdd:cd03795  311 VVPPKDPDALAEAIDKL 327
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 170-303 1.26e-11

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 65.39  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 170 EKIHVIYNAIDNQRFLPPDEETFaaLRAKWQLPLQATCLIYVGSGFERKG------LAAAIRAIAPtDRYLLVVGKDKDQ 243
Cdd:cd03812  158 GKFKVIPNGIDIEKYKFNKEKRR--KRRKLLILEDKLVLGHVGRFNEQKNhsflidIFEELKKKNP-NVKLVLVGEGELK 234

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 244 PRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVIT 303
Cdd:cd03812  235 EKIKEKVKELGLEDKVIFLGFRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLL 294
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 157-318 3.48e-11

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 64.00  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 157 IKREIIEDF----GLPAEKIHVIYNAIDNQRFlPPDEETFAALRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIAPT-- 230
Cdd:cd04951  137 VSREALDEFiakkAFSKNKSVPVYNGIDLNKF-KKDINVRLKIRNKLNLKNDEFVILNVGRLTEAKDYPNLLLAISELil 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 231 ---DRYLLVVGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITTTGC 307
Cdd:cd04951  216 sknDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQISNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAG 295

                        170
                 ....*....|.
gi 489011961 308 GGAEfIVDGHN 318
Cdd:cd04951  296 GVAE-VVGDHN 305
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 128-371 1.23e-10

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 63.13  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 128 DRYHRYVMQAEREMYEDSHLRGV--ICNAEMIKREIIEDFGLPAEKIHVIYNAIDNQRFL--PPDEETFAALRAKwqlpl 203
Cdd:PRK15179 438 DRPDRYRVEYDIIYSELLKMRGValSSNSQFAAHRYADWLGVDERRIPVVYNGLAPLKSVqdDACTAMMAQFDAR----- 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 204 QATCLIYVGSGFERKG---------LAAAIRAIAPTDRYLLVvGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQM 274
Cdd:PRK15179 513 TSDARFTVGTVMRVDDnkrpflwveAAQRFAASHPKVRFIMV-GGGPLLESVREFAQRLGMGERILFTGLSRRVGYWLTQ 591

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 275 ADGLLLPTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDALDI--PALQQAVMALPAR-ALGSAQGGHAR 351
Cdd:PRK15179 592 FNAFLLLSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEAVQEGVTGLTLPADTVtaPDVAEALARIHDMcAADPGIARKAA 671

                        250       260
                 ....*....|....*....|.
gi 489011961 352 ERIMACTS-ERLSTQLLSLYQ 371
Cdd:PRK15179 672 DWASARFSlNQMIASTVRCYQ 692
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
151-333 1.38e-10

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 62.80  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 151 ICNAEMIKREIIEDFGLPAEKIHVIYNAIdnqrfLPPDEETFAALRAK-WQLPLQAT---------CLIYVG--SGFERK 218
Cdd:PRK15490 343 MSNNHCVTRHYADWLKLEAKHFQVVYNGV-----LPPSTEPSSEVPHKiWQQFTQKTqdadttiggVFRFVGdkNPFAWI 417

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 219 GLAAAIRAIAPTDRYLLVvGKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACG 298
Cdd:PRK15490 418 DFAARYLQHHPATRFVLV-GDGDLRAEAQKRAEQLGILERILFVGASRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVG 496

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489011961 299 LPVITTTGCGGAEFIVDGHNGYVCDALDIPALQQA 333
Cdd:PRK15490 497 VPVISTPAGGSAECFIEGVSGFILDDAQTVNLDQA 531
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 148-372 2.86e-09

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 58.18  E-value: 2.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  148 RGVICNAEMIKREIIEDFGLPAEkihVIYNAIDNQRFLPPDEETFAALRAKWQLPLQATCLIyVGSGFERKGLAAAIRAI 227
Cdd:TIGR04047 140 DAVLCVSAAWAAELRAEWGIDAT---VVPNGVDAARFSPAADAADAALRRRLGLRGGPYVLA-VGGIEPRKNTIDLLEAF 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  228 APTDRYL----LVVGKDKDQPRYQALAKSLncEARVRFFGM------------QSETLPFYQMADGLLLPTLYDPFPNVI 291
Cdd:TIGR04047 216 ALLRARRpqaqLVIAGGATLFDYDAYRREF--RARAAELGVdpgpvvitgpvpDADLPALYRCADAFAFPSLKEGFGLVV 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  292 LEAMACGLPVITTTGCGGAEFiVDGHNGYVCDALDIPALQQAVMALPARALGSAQGGHARERIMACTSERLSTQLLSLYQ 371
Cdd:TIGR04047 294 LEALASGIPVVASDIAPFTEY-LGRFDAAWADPSDPDSIADALALALDPARRPALRAAGPELAARYTWDASARAHLEFYR 372


                  .
gi 489011961  372 D 372
Cdd:TIGR04047 373 R 373
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 162-373 2.02e-08

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 55.71  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 162 IEDfGLPAEKIHVIYNAIDNQRFlppdeetfAALRAKWQL-PLQATCLIyvGSGFERKGLAAAIRAIAPTDRYL-----L 235
Cdd:NF038011 273 IAD-GAPPERTRVIPNGIDLPRL--------APLRAQRPAgIPPVVGLI--GRVVPIKDIKTFIRAMRTVVRAMpeaegW 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 236 VVGKDKDQPRY----QALAKSLNCEARVRFFGMQ--SETLPfyQMadGLL-LPTLYDPFPNVILEAMACGLPVITT-TGC 307
Cdd:NF038011 342 IVGPEEEDPAYaaecRSLVASLGLQDKVKFLGFQkiDDLLP--QV--GLMvLSSISEALPLVVLEAFAAGVPVVTTdVGS 417

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489011961 308 -------GGAEFIVDGHNGYVCDALDIPALQQAVMALparaLGSAQGGHARERIMACTSERLSTQ--LLSLYQDL 373
Cdd:NF038011 418 crqliegLDEEDRALGAAGEVVAIADPQALARAALDL----LRDPQRWQAAQAAGLARVERYYTEelMFDRYREL 488
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 238-337 2.34e-08

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 55.00  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 238 GKDKDQPRYQALAKSLNCEARVRFFGMQSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVIT-TTGCGGAEFIVDG 316
Cdd:cd04949  198 GYGEEREKLKKLIEELHLEDNVFLKGYHSNLDQEYQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSyDVKYGPSELIEDG 277

                         90       100
                 ....*....|....*....|.
gi 489011961 317 HNGYVCDALDIPALQQAVMAL 337
Cdd:cd04949  278 ENGYLIEKNNIDALADKIIEL 298
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
95-320 7.64e-08

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 53.64  E-value: 7.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961  95 GCDLYRAG-DGVHRRWLQQRSRILP-AWKSRLL-----FADRYHRYV-----MQAEREMYEDS-------HL------RG 149
Cdd:PRK15484  57 NCDIHYIGfSRIYKRLFQKWTRLDPlPYSQRILniahkFTITKDSVIvihnsMKLYRQIRERApqaklvmHMhnafepEL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 150 VICNAEMI-KREIIEDF---GLPAEKIHVIYNAIDNQRFlppDEETFAALRAKWQLPLQATCLIYVGSGFERKGLAAAIR 225
Cdd:PRK15484 137 LDKNAKIIvPSQFLKKFyeeRLPNADISIVPNGFCLETY---QSNPQPNLRQQLNISPDETVLLYAGRISPDKGILLLMQ 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 226 AI-----APTDRYLLVVG-----KDKDQPRYQA----LAKSLNceARVRFFGMQS--ETLPFYQMADGLLLPTLY-DPFP 288
Cdd:PRK15484 214 AFeklatAHSNLKLVVVGdptasSKGEKAAYQKkvleAAKRIG--DRCIMLGGQPpeKMHNYYPLADLVVVPSQVeEAFC 291

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489011961 289 NVILEAMACGLPVITTTGCGGAEFIVDGHNGY 320
Cdd:PRK15484 292 MVAVEAMAAGKPVLASTKGGITEFVLEGITGY 323
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 168-356 3.19e-06

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 48.51  E-value: 3.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 168 PAE---KIHVIYNAIDNQRFLPPDEetfAALRAKWQLPLQATCLI--YVGSGFER-KGLAAAIRAIA------PTDRyLL 235
Cdd:cd03818  174 PAAyrdRISVIHDGVDTDRLAPDPA---ARLRLLNGTELKAGDPVitYVARNLEPyRGFHVFMRALPriqarrPDAR-VV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 236 VVGKDK----------DQPRYQALAKSLNCEARVRFFGM--QSETLPFYQMADGLLLPTlydpFPNV----ILEAMACGL 299
Cdd:cd03818  250 VVGGDGvsygspppdgGSWKQKMLAELGVDLERVHFVGKvpYDQYVRLLQLSDAHVYLT----YPFVlswsLLEAMACGC 325

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 300 PVITTTGCGGAEFIVDGHNGYVCDALDIPALQQAVMAL---PARAlgSAQGGHARERIMA 356
Cdd:cd03818  326 PVIGSDTAPVREVIRDGRNGLLVDFFDPDALAAAVLELledPDRA--AALRRAARRTVER 383
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 150-334 3.25e-06

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 48.44  E-value: 3.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 150 VICNAEMIKREIIEDFGLPAEkihVIYNAIDNQRFLP-PDEETFaalrakwqlplqatcliYVGSGF--ERKGLAAAIRA 226
Cdd:cd03804  161 FIANSQFVARRIKKFYGREST---VIYPPVDTDAFAPaADKEDY-----------------YLTASRlvPYKRIDLAVEA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 227 IAPTDRYLLVVGKDKDQPRYQALAKslnceARVRFFGMQS--ETLPFYQMADGLLLPTLYDpFPNVILEAMACGLPVItT 304
Cdd:cd03804  221 FNELPKRLVVIGDGPDLDRLRAMAS-----PNVEFLGYQPdeVLKELLSKARAFVFAAEED-FGIVPVEAQACGTPVI-A 293

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489011961 305 TGCGGA-EFIVDGHNGYVCDALDIPALQQAV 334
Cdd:cd03804  294 FGKGGAlETVRPGPTGILFGEQTVESLKAAV 324
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 215-356 4.34e-06

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 48.35  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 215 FER-KGLAAAIRAIA-------PTDRYLLVV--GKDKDQP---RY----QALAKSL-NCEARVRFFGMQSETLPFYQMAD 276
Cdd:cd03805  220 FERkKNIALAIEAFAklkqklpEFENVRLVIagGYDPRVAenvEYleelQRLAEELlNVEDQVLFLRSISDSQKEQLLSS 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 277 GLLLptLYDP----FPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCDAldIPALQQAVMALPARALGSAQ--GGHA 350
Cdd:cd03805  300 ALAL--LYTPsnehFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEP--TPEAFAEAMLKLANDPDLADrmGAAG 375


                 ....*.
gi 489011961 351 RERIMA 356
Cdd:cd03805  376 RKRVKE 381
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 245-323 2.37e-05

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 45.91  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 245 RYQALAKSLNCEARVRFFGM--QSETLPFYQMADglllptlYDPFPNV---------ILEAMACGLPVITTTGCGGAEFI 313
Cdd:cd04946  271 RLEKLAENKLENVKVNFTGEvsNKEVKQLYKEND-------VDVFVNVsesegipvsIMEAISFGIPVIATNVGGTREIV 343

                         90
                 ....*....|
gi 489011961 314 VDGHNGYVCD 323
Cdd:cd04946  344 ENETNGLLLD 353
PLN00142 PLN00142
sucrose synthase
 281-323 3.95e-05

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 45.74  E-value: 3.95e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489011961 281 PTLYDPFPNVILEAMACGLPVITTTGCGGAEFIVDGHNGYVCD 323
Cdd:PLN00142 673 PALYEAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGFHID 715
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 166-304 1.81e-04

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 43.38  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 166 GLPAEKIHVIYNAIDNQRFLPPDEetfaalrakwQLPLQATCLIYVGSGFERKGLAAAIRAIAP-----TDRYLLVVGkd 240
Cdd:cd03796  164 SLDPRIVSVIPNAVDSSDFTPDPS----------KPDPNKITIVVISRLVYRKGIDLLVGIIPRickkhPNVRFIIGG-- 231

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489011961 241 kDQPRY---QALAKSLNCEARVRFFGM--QSETLPFYQMADGLLLPTLYDPFPNVILEAMACGLPVITT 304
Cdd:cd03796  232 -DGPKRielEEMREKYQLQDRVELLGAvpHEEVRDVLVQGHIFLNTSLTEAFCIAIVEAASCGLLVVST 299
PRK10307 PRK10307
colanic acid biosynthesis glycosyltransferase WcaI;
166-353 7.18e-04

colanic acid biosynthesis glycosyltransferase WcaI;


Pssm-ID: 236670 [Multi-domain]  Cd Length: 412  Bit Score: 41.50  E-value: 7.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 166 GLPAEKIHVIYNAIDNQRFLPPDEETFAALRAKWQLPLQATCLIYVGSGFERKGL----AAAIRAIAPTDRYLLVVGKDK 241
Cdd:PRK10307 190 GVAAEKVIFFPNWSEVARFQPVADADVDALRAQLGLPDGKKIVLYSGNIGEKQGLelviDAARRLRDRPDLIFVICGQGG 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 242 DQPRYQALAKSLNCeARVRFFGMQS-ETLP-FYQMADGLLLPTLYDP----FPNVILEAMACGLPVITTTGCGGAEFIVD 315
Cdd:PRK10307 270 GKARLEKMAQCRGL-PNVHFLPLQPyDRLPaLLKMADCHLLPQKAGAadlvLPSKLTNMLASGRNVVATAEPGTELGQLV 348

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489011961 316 GHNGYVCDALDIPALQQAVMALPARALG-SAQGGHARER 353
Cdd:PRK10307 349 EGIGVCVEPESVEALVAAIAALARQALLrPKLGTVAREY 387
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 168-337 3.14e-03

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 39.29  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 168 PAEKIHVIYNAIdnqrFLPPDEETFAalRAKWQLPLQATCLIYVGSGFERKGLAAAIRAIA-----PTDRYLLVVGK-DK 241
Cdd:cd03822  156 PAVNIEVIPHGV----PEVPQDPTTA--LKRLLLPEGKKVILTFGFIGPGKGLEILLEALPelkaeFPDVRLVIAGElHP 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489011961 242 DQPRYQALAKslnCEARVRFFGMQS-----------ETLPFY-QMADGLLLPtlydpFPN-------VILEAMACGLPVI 302
Cdd:cd03822  230 SLARYEGERY---RKAAIEELGLQDhvdfhnnflpeEEVPRYiSAADVVVLP-----YLNteqsssgTLSYAIACGKPVI 301

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489011961 303 TTTgCGGAEFIVDGHNGYVCDALDIPALQQAVMAL 337
Cdd:cd03822  302 STP-LRHAEELLADGRGVLVPFDDPSAIAEAILRL 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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