|
Name |
Accession |
Description |
Interval |
E-value |
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
1-394 |
0e+00 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 611.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 1 MSHSNETKPHARDLARPNWSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIG 80
Cdd:PRK10213 1 MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 81 KTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIA 160
Cdd:PRK10213 81 ATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 161 APLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIR 240
Cdd:PRK10213 161 APLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 241 PVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFA 320
Cdd:PRK10213 241 PVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489012677 321 LIPVGWSTWITRSLSDQAEKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVAAKVKVN 394
Cdd:PRK10213 321 LVPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMK 394
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-388 |
4.51e-63 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 206.63 E-value: 4.51e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 22 VFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLL 101
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 102 VSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAA 181
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 182 VMGVLCTLWVLKALPSLPGESASQQQ---NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVL 258
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 259 LSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLSDQA 338
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489012677 339 EKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVA 388
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
16-369 |
1.58e-39 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 145.03 E-value: 1.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 16 RPNWSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLL 95
Cdd:PRK03545 5 KVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 96 TLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRN 175
Cdd:PRK03545 85 IASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 176 VFNGAAVMGVLCTLWVLKALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLT 255
Cdd:PRK03545 165 TFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFAT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 256 LVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLS 335
Cdd:PRK03545 245 LLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLAP 324
|
330 340 350
....*....|....*....|....*....|....
gi 489012677 336 DQAEKAGSIQVAVIQLANTCGAAVGGIALDHLGL 369
Cdd:PRK03545 325 DATDVAMALFSGIFNIGIGAGALLGNQVSLHLGL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-338 |
1.03e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.46 E-value: 1.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 15 ARPNWSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLL 94
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 95 LTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWR 174
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 175 NVFNGAAVMGVLCTLWVLKALP-SLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDG 253
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPeSRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 254 LTLVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRS 333
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
....*
gi 489012677 334 LSDQA 338
Cdd:COG2814 325 APPEA 329
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
22-314 |
2.86e-20 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 91.31 E-value: 2.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 22 VFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLL 101
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 102 VSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAA 181
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 182 VMGVLCTLWVLKALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSF 261
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLV 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 489012677 262 GIASFIGTSLSSVLLKRSVKAALA-IAPLVLTACAVALVLWGESKIIASTVAII 314
Cdd:PRK10091 245 GLGMVLGNLLSGRLSGRYSPLRIAaVTDFIIVLALLMLFFFGGMKTASLIFAFI 298
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-388 |
2.49e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.56 E-value: 2.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 25 VAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 105 ADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFL--GGLIGWRNVFNGAAV 182
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 183 MGVLCTLWVLKALPSLPGE---------SASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDG 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESarakneeasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 254 LTLVLLSFGIASFIGTSLSSVLLKR--SVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWIT 331
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRliGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489012677 332 RSLSDQAEKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVA 388
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-387 |
2.04e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 83.01 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 26 AFCVACLITVEFLPVSLLTP----MALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLL 101
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPalpaIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 102 VSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAA 181
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 182 VMGVLCTLWVLKALP-SLPGESASQQ-----QNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLT 255
Cdd:cd17320 161 LLGLLLLLLVLLFLPeTLPEEKRKPLlssllRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 256 LVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGW--STWITRS 333
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLifPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489012677 334 LSDQAEKAGSIQvAVIQLANTCGAAVGGIALDHLGLLSPLVLsGILMLFTGLLV 387
Cdd:cd17320 321 LEPFPHVAGTAS-ALLGFLQFLIGALAGALVGLLPNGTALPM-GLLILVLGLLA 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-391 |
1.00e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.08 E-value: 1.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 25 VAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSF 104
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 105 ADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMG 184
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 185 VLCTLWVLKALPSLPGESASQ-------QQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMT-LAGFDVDGLTL 256
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRavsaarlRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL-PLYAAeLGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 257 VLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLSD 336
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489012677 337 QA-EKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVAAKV 391
Cdd:cd17325 320 EGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-334 |
3.39e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 3.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 37 FLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRA 116
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 117 CLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALP 196
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 197 SLPGESASQQQ-------NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFIGT 269
Cdd:pfam07690 174 PPESKRPKPAEearlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489012677 270 SLSSVLLKR---SVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSL 334
Cdd:pfam07690 253 LLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-322 |
1.96e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.23 E-value: 1.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 19 WSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLS 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 99 CLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFN 178
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 179 GAAVMGVLCTLWVLKALPSLPGESASQQQ----NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGL 254
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKaslrDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489012677 255 TLVLLSFGIASFIGTSLSSVLLKR-SVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALI 322
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRiGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGG 312
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-388 |
3.84e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.06 E-value: 3.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 19 WSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLS 98
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 99 CLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFN 178
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 179 GAAVMGVLCTLWvlkalpslpgesasqqqnmfgllkrpGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVL 258
Cdd:COG2271 169 ILGLPGLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 259 LSFGIASFIGTSLSSVL---LKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLS 335
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLsdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489012677 336 DQAEKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVA 388
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
37-322 |
3.69e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.01 E-value: 3.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 37 FLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRA 116
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 117 CLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTL--WVLKA 194
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLlvFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 195 LPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLlsFGIASFIGTSLSSV 274
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL-PLYAAERGISNAGLFFTV--YAIALLLSRPFSGK 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 489012677 275 LLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALI 322
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLL 297
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
41-397 |
5.17e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 5.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 41 SLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGL 120
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 121 ALGGFWAMSASLTMRLVPmRVVPKALSIIFGAVSIALVIAAPLGSFL---GGLIGWRNVFNGAAVMGVLCTLWV----LK 193
Cdd:COG0738 109 GLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFlrskLP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 194 ALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSS 273
Cdd:COG0738 188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 274 VLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALI-PVGWStWITRSLSDQAEKAGSIQVAVIQLA 352
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFS-LALDGLGKRTAAAVSAVLIMGIVG 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489012677 353 NTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVAAKVKVNSPA 397
Cdd:COG0738 347 GAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-389 |
2.70e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.43 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 25 VAFCVACLITveFLPVSLLTP----MALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCL 100
Cdd:cd17474 2 YAVFFATLLA--VLGVSIVDPilpaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 101 LVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLgGLIGWRNVFNG- 179
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 180 AAVMGVLCTLWVLKALPSLPGESASQQQN---MFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTL 256
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKlrdLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 257 VLLSFGIASFIGTSLSSVLLKR--SVKAALAIApLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRsL 334
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKrfGARRILVIG-LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE-L 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489012677 335 SDQAEKAGSIQV--AVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVAA 389
Cdd:cd17474 317 APEEERGTASSLynFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
104-387 |
4.93e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 104 FADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVM 183
Cdd:cd17319 87 FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 184 GVLCTLWVLKALPSlpgesasqqqnmfgllkrpgvMAGMCAIFMAFAGQFAFFTYIRPVYM-TLAGFDVDGLTLVLLSFG 262
Cdd:cd17319 167 GLLLAVLWWFYLRQ---------------------VWGLALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLLAAIPF 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 263 IASFIGTSLSSVLLKRSVKAA---LAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLSD-QA 338
Cdd:cd17319 226 LAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAA 305
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489012677 339 EKAGSIQVAVIQLANTCGAAVGGIALDHLG-LLSPLVLSGILMLFTGLLV 387
Cdd:cd17319 306 ATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLV 355
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
104-385 |
9.63e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.54 E-value: 9.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 104 FADSFTLLLLGRAclglaLGGFWAMSA---SLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGA 180
Cdd:cd17472 81 YATSIYGLILGRA-----LQGSGAISSvvmALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLIT 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 181 AVMGVLC---TLWVLKALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLV 257
Cdd:cd17472 156 AILSLVSlliLLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYIL-PLLLTQLGGGKGQLWKV 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 258 LLSFGIASFIGTSLSSVLL--KRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLS 335
Cdd:cd17472 235 YLPAILIGFILMVPFVIYAekKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAP 314
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489012677 336 DQAEKAGSIQVAVIQ-LANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGL 385
Cdd:cd17472 315 KEYRGTAMGIYNTSQfLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-322 |
1.02e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.43 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 50 LGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFwaMS 129
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI--MT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 130 ASLTM---------RLvpmrvvpKALSIIFGAVSIALVIAAPLGSFLGGlIGWRNVF--NGAAVMGVLCTLWVLKALPSL 198
Cdd:cd17473 108 LATALigdyfegeeRA-------KMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFlvYLLALPVLILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 199 PGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKR 278
Cdd:cd17473 180 SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489012677 279 SVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALI 322
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
47-325 |
1.24e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.07 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 47 ALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFW 126
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 127 AMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFL----GGLIGWRNVFNGAAVMGVLctlwvlkalpslpges 202
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPALL---------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 203 asqqqnmfGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKR-SVK 281
Cdd:cd17316 172 --------ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRiGRK 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489012677 282 AALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVG 325
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWG 287
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
107-387 |
4.06e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 107 SFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAV---- 182
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsfll 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 183 MGVLCTLWVLKALPSLPGESASQQQNMFG----LLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVL 258
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 259 LSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLSDQ- 337
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEl 330
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489012677 338 AEKAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLV 387
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
46-334 |
5.22e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.12 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 46 MALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGF 125
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 126 wAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLwvlkALPSLPgesasq 205
Cdd:cd17504 102 -PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPLID------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 206 qqnmFGLLKRPGVMAGMCAIFMAFAGQFAFFtYIRPVYM-----TLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKR-S 279
Cdd:cd17504 171 ----LRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLqlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvG 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489012677 280 VKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSL 334
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESV 300
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-388 |
2.62e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 4 SNETKPHARDLARPNWSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTD 83
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 84 RRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRvVPKALSIIFGAVSIALVIAAPL 163
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 164 GSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALPSLPGES--ASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrP 241
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAaaAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL-P 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 242 VYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFAL 321
Cdd:COG2807 240 PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012677 322 IPVGWSTWITRSLSDQAEkAGSIqVAVIQLANTCGAAVG----GIALDHLG----LLSPLVLSGILMLFTGLLVA 388
Cdd:COG2807 320 LFPLALTLIGLRARTPAE-AAAL-SGMAQSVGYLLAALGpllvGALHDATGswtaALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
104-364 |
4.83e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 4.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 104 FADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVM 183
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 184 GVLCTLwvlkALPSLPgesasqqqnmFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGI 263
Cdd:cd17503 160 GILALL----LAPLLD----------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 264 ASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLW---GESKIIASTVAIIWGFAFALIPVGWSTWITRSLS-DQAE 339
Cdd:cd17503 226 ASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPpEQIG 305
|
250 260
....*....|....*....|....*
gi 489012677 340 KAGSIQVAVIQLANTCGAAVGGIAL 364
Cdd:cd17503 306 DATALFNTIRQLGGSIGTALLATLL 330
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
15-301 |
1.09e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 15 ARPNWSAVFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLL 94
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 95 LTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWR 174
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 175 NVFNGAAVMGVLCTLWVLKALPSLPGESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGL 254
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489012677 255 TLVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLW 301
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
49-245 |
2.85e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 49 DLGISEGMAGQSVTTTAFVAMFSSLFITTVIGK-TDRRYVVILFSLLLTLSCLLVSFADSFTLLLLgracLGLALGGFWA 127
Cdd:cd17471 26 ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLL----VGVVLLSLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 128 MSASLTMRLV-------PMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALPSLPG 200
Cdd:cd17471 102 AAFPQLFALAreyadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKP 181
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 489012677 201 ESASQQQN--MFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMT 245
Cdd:cd17471 182 PAQKATPAssLVKAPVNRRLLLLFAAFTLLFAANSMYIIAM-PLYVT 227
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-196 |
3.90e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.51 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 49 DLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAM 128
Cdd:TIGR00895 46 EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPN 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489012677 129 SASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALP 196
Cdd:TIGR00895 126 LNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-189 |
1.37e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 45 PMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGG 124
Cdd:cd17365 24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012677 125 FWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTL 189
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-325 |
1.62e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 104 FADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVM 183
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 184 GVLCTLWVlkalpslpgesasqqqnmfgllkrPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGI 263
Cdd:cd17321 160 GLVALLLA------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLAL 215
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489012677 264 ASFIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWgeskIIASTVAIIWGFAFALIPVG 325
Cdd:cd17321 216 AMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL----LGADSSVWLLLPGLVLLGLG 273
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-196 |
1.69e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.18 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 61 VTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMR 140
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 489012677 141 VVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALP 196
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-381 |
1.85e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.42 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 22 VFAVAFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLL 101
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 102 VSFADSFTLLLLGRACLGLALGGFwAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAA 181
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 182 VMGVLCTLWVLKALPSLpgesasqqqnmFGLLkrpGVMAGMCAIFMAFAGQFAFFTYIRPvymtlaGFDVDGLTLVLLSF 261
Cdd:cd17330 160 ALALLNLVLVLFFLPPL-----------RRLL---LVYFLIALAFAGLESVFSLFLKDRF------GFSPSQIGLLLALV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 262 GIAS-FIGTSLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRSLSDQAE- 339
Cdd:cd17330 220 GIAGiLAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQg 299
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489012677 340 KAGSIQVAVIQLANTCGAAVGGIALDHLGLLSPLVLSGILML 381
Cdd:cd17330 300 KAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLL 341
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-389 |
1.87e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.45 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 40 VSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSL---FITTVIGKtdRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRA 116
Cdd:cd17490 16 VPFLSPYAESLGASLSMIGIILGAYGISQMLLRIplgILSDRIGK--RKLFIIIGLLFTVLASLIMILFPSPWGLLIARF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 117 CLGLAlGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVF---NGAAVMGVLCTLwVLK 193
Cdd:cd17490 94 LSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSL-FIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 194 ALPSLPGESASQQQNMFGLLKRPGVM-AGMCAIFMAFAgQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLS 272
Cdd:cd17490 172 EERREKKPVLTELKELLSVLKDKKLLfFSLLAILQQMI-TFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 273 SVLLKRSVKA-ALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALI-PVGWSTWITRSLSDQAEKAGSIQVAVIQ 350
Cdd:cd17490 251 GTLFYKKLGErNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYA 330
|
330 340 350
....*....|....*....|....*....|....*....
gi 489012677 351 LANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVAA 389
Cdd:cd17490 331 LGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
50-391 |
2.30e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 50 LGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRY---------------VVILFSLLLTLSCLLVSFADSFTLLLLG 114
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaiplaLSFVLLFTAPDLSPTGKLIYALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 115 RACLGLALGGFWAMSASLT------MRLVPMRVVpkalsIIFGAVSIALVIAAPLGSFLGG--LIGWRNVFNGAAVMGVL 186
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTpdyeerTRLSSWRFA-----FAGLGGLLASVLPPPLVAAFGGdaALGYRLTALIFAVLGLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 187 CTLWVLKALPSLPGESASQQ---QNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGI 263
Cdd:COG2211 196 AFLLTFFGTKERPVPEEEKVslkESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 264 ASFIGTSLSSVLLKR-SVKAALAIAPLVLTACAVALVLWGESKIIASTVA-IIWGFAFALIPVGWSTWITRSLSDQAEKA 341
Cdd:COG2211 276 AALLGAPLWPRLAKRfGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLaALAGIGLGAILVLPWAMLADVVDYDEWKT 355
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489012677 342 G--------SIQVAVIQLANTCGAAVGGIALDHLG-----LLSPLVLSGILMLFTGLLVAAKV 391
Cdd:COG2211 356 GrrreglyfGIFTFAIKLGQALAGALAGLLLALFGyvagaAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
42-278 |
1.01e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.22 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 42 LLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLA 121
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 122 LGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSI----ALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCtLWVLKALPS 197
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLLGALPALLV-LFIRRFVKE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 198 LPGESASQQQNM-------FGLLKRPGVMAGMCAIFMAFAGQ---FAFFTYIRPVYMTLA-GFDVDGLTLVLLSFGIASF 266
Cdd:cd17371 180 PPQWQAARAARRhfadrpsLRELFSPPLLRTTLLASLLATGAlggYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGF 259
|
250
....*....|..
gi 489012677 267 IGTSLSSVLLKR 278
Cdd:cd17371 260 LGYLAGGFLADR 271
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-388 |
1.19e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 37 FLPVsLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRA 116
Cdd:cd17478 14 FLPA-LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 117 CLGLALGGFWAMSASLTMRLVPMRVvPKALSI--IFGAVSIAL--VIAAPLGSFLGGLiGWRNVFNGAAVMGVLCTLWVL 192
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGRR-GLAMSIfsVGGNLGFALgpLIAAALVALFGGL-GLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 193 KALPSLPGESASQQQNMFGL-LKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFIGTSL 271
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLkGVWRALLLLLIIVFLRSWVLSSLTTFL-PFYLVQRGYSLVFAGLLLSLFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 272 SSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGwSTWITRSLSDQAEKAGSIQVAVIQL 351
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVT-VVLAQELLPGNVGLASGLMMGLSFG 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 489012677 352 ANTCGAAVGGIALDHLGLLSPLVLSGILMLFTGLLVA 388
Cdd:cd17478 329 LGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
49-269 |
3.46e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.61 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 49 DLGISEgMAGQSVTTTAFVAM-FSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWA 127
Cdd:PRK12307 47 DLGLTD-MEGAFLATAAFIGRpFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 128 MSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNgAAVMGVLCTLWVLKALPS--------LP 199
Cdd:PRK12307 126 CASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFF-VGLLPVLLVIYIRARAPEskeweeakLS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 200 GESASQQQ-------NMFGLLKRPGVMAGMC---AIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFIGT 269
Cdd:PRK12307 205 GKGKHSQSawsvfslSMKGLFNRAQFPLTLCvfiVLFSIFGANWPIFGLL-PTYLAGEGFDTGVVSNLMTAAAFGTVLGN 283
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
56-195 |
3.57e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.25 E-value: 3.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 56 MAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMR 135
Cdd:cd17391 241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 136 LVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKAL 195
Cdd:cd17391 321 ITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-388 |
4.82e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 4.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 49 DLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAM 128
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 129 SASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLiGWRNVFNGAAVMGVLCTLWVLKALP-----SLPGESA 203
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPetrpkRRAAEKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 204 SQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKRSVKAA 283
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 284 LAIAPLVLTACAVALVLWGESKIIASTVAIIWGFAFALIPVGWSTWITRsLSDQAEKAGSIQVA--VIQLANTCGAAVGG 361
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA-LAPPDKRGSYMGFYalAWGLGRAIGPLVGG 346
|
330 340
....*....|....*....|....*..
gi 489012677 362 IALDHLGLLSPLVLSGILMLFTGLLVA 388
Cdd:cd17329 347 LLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-194 |
1.23e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 21 AVFAVAFCVACLITVEFLPVSLLTPMALD-LGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSC 99
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 100 LLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNG 179
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
|
170
....*....|....*
gi 489012677 180 AAVMGVLCTLWVLKA 194
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-323 |
1.94e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 42 LLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLA 121
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 122 LGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSF-LGGLIGWRNVFNGAAVMGVLCTLWVLKALPSLPG 200
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 201 ESASQQQNMFGLLKRPGVMAGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKR-S 279
Cdd:cd06180 181 APTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFL-PLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRwG 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489012677 280 VKAALAIApLVLTACAVALVLWGESKIIASTVAIIWGFAFALIP 323
Cdd:cd06180 260 TRRALAAN-LLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAIT 302
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
119-389 |
2.67e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 119 GLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALPSL 198
Cdd:cd17355 103 GGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRR 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 199 PGESASQQQNM---------FGLLKRPGVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVDGLTLVLLSFGIASFIGT 269
Cdd:cd17355 183 PADLALRAYDDaspaspgstLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGR 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 270 SLSSVLLKRSVKAALAIAPLVLTACAVALVLWGESKIIASTVAIIwGFAFALIPVGWSTWITRSLSDQAEKAGSI---QV 346
Cdd:cd17355 263 LLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAA-LFGLGWGATVPLTAALAARYFGARSYGTLfglVF 341
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489012677 347 AVIQLANTCGAAVGGIALDHLG-LLSPLVLSGILMLFTGLLVAA 389
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLP 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-196 |
2.84e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 21 AVFAVAFCVACLITVEFLPVSLLTPMALD-LGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRY--VVILFSLLLTL 97
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 98 SCLLVSFADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVF 177
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170
....*....|....*....
gi 489012677 178 NGAAVMGVLCTLWVLKALP 196
Cdd:COG2271 341 LLLAALALLAALLALLLLR 359
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-238 |
3.57e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 46 MALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGF 125
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 126 WAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKAL-----PSLPG 200
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYreppaASAAT 181
|
170 180 190
....*....|....*....|....*....|....*....
gi 489012677 201 ESASQQQ-NMFGLLKRPGVMAGMCAIFMAFAGQFAFFTY 238
Cdd:cd17475 182 ESASTLLrSLKEVLRNRDVWLIAIAGALLVAPQFALLTF 220
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
36-300 |
4.39e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 36 EFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGR 115
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 116 ACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFgavsialvIAAPLGSFLGGLIG---------WRNVFNGAAVMGVL 186
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY--------FAIPLGSGLGYVVGglvaqatggWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 187 C---TLWVLKALPSLPGESASQQQN--------MFGLLKRPGVM----AGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDV 251
Cdd:cd17328 167 LailLLLFVREPPRGAAEGGVMAKStatsfladLKALAKNPSFIlstlGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSA 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489012677 252 DGLTLVLLSFGIASFIGTSLSSVLLKRSVKAALAIAPLVltaCAVALVL 300
Cdd:cd17328 247 DVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLV---CAVGLLA 292
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-387 |
4.77e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 51 GISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGGFWAMSA 130
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 131 SLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWrnVFNGAAVMGVLCTLWVLKALPSLPGESASQQQNMF 210
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 211 GLLKRPGVmaGMCAIFMAFAGQFAFFTYIrPVYMTLAGFDVDGLTLVLLSFGIASFIGTSLSSVLLKRSVK-AALAIAPL 289
Cdd:cd17477 185 RLLRIAPL--ALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRrRVLLGCAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 290 VLTACAVALVLWGESKIIASTVAIIWG-FAFALIPVGwSTWITRSLSDQAEKAGSIQVAVIQ-LANTCGAAVGGIALDHL 367
Cdd:cd17477 262 LGALAALLLPLVPGLPLALLVLLFLWGgAAGPLYTLA-LALAGDRLPGDELVAANAALLLLYgLGSVIGPLLAGALMDAF 340
|
330 340
....*....|....*....|
gi 489012677 368 GLLSPLVLSGILMLFTGLLV 387
Cdd:cd17477 341 GPHGLFLFLAAVALLFLLFL 360
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
46-201 |
4.92e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.73 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 46 MALDLGISEGMAgQSVTTTAFVAM-FSSLFITTVIGKTDRRYVVILFSLLLTLSCLLVSFADSFTLLLLGRACLGLALGG 124
Cdd:PRK11652 34 MARDLNVREGAV-QAVMAAYLLTYgLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGV 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489012677 125 FWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALP-SLPGE 201
Cdd:PRK11652 113 GGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPeTRPAD 190
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
144-278 |
6.86e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 38.36 E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 144 KALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGVLCTLWVLKALP-SLPGES------ASQQQNMFGLLKRP 216
Cdd:PRK11102 115 RMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPeTLPKERrqpfhlRTTIRNFASLFRHK 194
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489012677 217 GVMAGMCAIFMAFAGQFAFFTYIRPVYMTLAGFDVD------GLTLVLLsfgiasFIGTSLSSVLLKR 278
Cdd:PRK11102 195 RVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQnfgyyfALNIVFL------FVMTIINSRFVRR 256
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
107-196 |
7.78e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 7.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 107 SFTLLLLGRACLGLALG-GFWAMsASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFLGGLIGWRNVFNGAAVMGV 185
Cdd:cd17380 88 SLPLLILSRILLGLGEGvHFPSM-TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL 166
|
90
....*....|..
gi 489012677 186 L-CTLWVLKALP 196
Cdd:cd17380 167 LwALVWLIYLPP 178
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
26-167 |
9.21e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012677 26 AFCVACLITVEFLPVSLLTPMALDLGISEGMAGQSVTTTAFVAMFSSLFITTVIGKTDRR--YVVILFSLLLTLSCLLVS 103
Cdd:cd17352 189 ALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGrlYLYIFTLLILGLSLLAFP 268
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489012677 104 FADSFTLLLLGRACLGLALGGFWAMSASLTMRLVPMRVVPKALSIIFGAVSIALVIAAPLGSFL 167
Cdd:cd17352 269 LATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLL 332
|
|
| |
