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Conserved domains on  [gi|489048336|ref|WP_002958554|]
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MULTISPECIES: peptide chain release factor 1 [Pseudoalteromonas]

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 712.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   4 SVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKD-SDPEMREMAQE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  83 EYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 163 EVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 243 DSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRITDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489048336 323 RINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 712.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   4 SVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKD-SDPEMREMAQE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  83 EYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 163 EVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 243 DSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRITDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489048336 323 RINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-360 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 694.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   2 KESVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKD-SDPEMREMA 80
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  81 QEEYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 161 YKEVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVN 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVE-VEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 241 KTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRIT 320
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489048336 321 DHRINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMGD 360
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-361 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 580.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336    1 MKESVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDSDPEMREMA 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEESDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   81 QEEYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGG 160
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  161 YKEVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVN 240
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  241 KTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRIT 320
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 489048336  321 DHRINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMGDE 361
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-205 2.07e-116

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 335.51  E-value: 2.07e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   12 LVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDsdPEMREMAQEEYKEAKAQI 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED--PELAELAEEELEELEKRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   92 LVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGE 171
Cdd:pfam03462  79 EELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGE 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 489048336  172 GVYGQLKFESGVHRVQRVPETESQGRVHTSACTV 205
Cdd:pfam03462 159 GAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
66-180 5.83e-59

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 186.13  E-value: 5.83e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336    66 EEMLKDSDPEMREMAQEEYKEAKAQIL-VIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENK 144
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEeELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 489048336   145 KWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFE 180
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 4-359 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 712.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   4 SVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKD-SDPEMREMAQE 82
Cdd:COG0216    1 SMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEeSDPEMREMAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  83 EYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYK 162
Cdd:COG0216   81 ELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 163 EVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVNKT 242
Cdd:COG0216  161 EVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVD-VEINPKDLRIDTFRSSGAGGQHVNTT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 243 DSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRITDH 322
Cdd:COG0216  240 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDH 319

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489048336 323 RINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMG 359
Cdd:COG0216  320 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 2-360 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 694.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   2 KESVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKD-SDPEMREMA 80
Cdd:PRK00591   1 KPSMLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEeSDPEMREMA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  81 QEEYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGG 160
Cdd:PRK00591  81 KEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 161 YKEVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVN 240
Cdd:PRK00591 161 YKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVE-VEINPKDLRIDTFRSSGAGGQHVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 241 KTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRIT 320
Cdd:PRK00591 240 TTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 489048336 321 DHRINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMGD 360
Cdd:PRK00591 320 DHRINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-361 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 580.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336    1 MKESVYNKLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDSDPEMREMA 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEESDPEMREMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   81 QEEYKEAKAQILVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGG 160
Cdd:TIGR00019  81 KEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  161 YKEVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEaIQINTADLKVDTFRASGAGGQHVN 240
Cdd:TIGR00019 161 YKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVE-VDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  241 KTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSERIRTYNYPQGRIT 320
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 489048336  321 DHRINLTLYRLNEVVAGDLSAIIDPLMQEHQADLLAAMGDE 361
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSEE 360
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 12-205 2.07e-116

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 335.51  E-value: 2.07e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   12 LVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDsdPEMREMAQEEYKEAKAQI 91
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLED--PELAELAEEELEELEKRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   92 LVIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGE 171
Cdd:pfam03462  79 EELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGE 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 489048336  172 GVYGQLKFESGVHRVQRVPETESQGRVHTSACTV 205
Cdd:pfam03462 159 GAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-344 8.90e-89

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 271.26  E-value: 8.90e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336    8 KLETLVERYEEVQALLSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDSDPEmrEMAQEEYKEA 87
Cdd:TIGR00020  24 DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDE--ETFNELDAEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336   88 KAQILVIEDQIQVLMLpKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIAN 167
Cdd:TIGR00020 102 KALEKKLAELELRTML-SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTIL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  168 ISGEGVYGQLKFESGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEAIQINTADLKVDTFRASGAGGQHVNKTDSAIR 247
Cdd:TIGR00020 181 IKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVR 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  248 LTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEASERRDLVGSGDRSErIRTYNY-PQGRITDHRINL 326
Cdd:TIGR00020 261 ITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQ-IRSYVLhPYSMVKDLRTGY 339

                         330
                  ....*....|....*...
gi 489048336  327 TLYRLNEVVAGDLSAIID 344
Cdd:TIGR00020 340 ETGNVQAVLDGDIDQFIE 357
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 25-344 2.71e-69

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 220.52  E-value: 2.71e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  25 DPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDD----LASAEEmlkDSDPEMREMAQEEYKEAKAQIlvieDQIQV 100
Cdd:PRK07342   5 DPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDnielIAMGEE---EGDKSIVEDAEKTIRDLKDEI----DRRQI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 101 LMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFE 180
Cdd:PRK07342  78 DALLSGEADANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 181 SGVHRVQRVPETESQGRVHTSACTVAVMAEVPEAEAIQINTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQ 260
Cdd:PRK07342 158 SGVHRLVRISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 261 DQRSQHKNRAKAMSVLAARLQQAEDEKRHA---AEASERRDlVGSGdrsERIRTYNY-PQGRITDHRINLTLYRLNEVVA 336
Cdd:PRK07342 238 QERSQHKNRAKAWSMLRARLYEEELKKREEatnAAAASKTD-IGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLD 313


                 ....*...
gi 489048336 337 GDLSAIID 344
Cdd:PRK07342 314 GDLNEFME 321
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 23-343 3.82e-68

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 217.37  E-value: 3.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  23 LSDPSVISDQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDSDPEMREMAQEEYKEAKAQIlvieDQIQVLM 102
Cdd:PRK05589   1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDDEMKKEIISEVKNIKEEI----DRFKIET 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 103 LPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFESG 182
Cdd:PRK05589  77 LLSGEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 183 VHRVQRVPETESQGRVHTSACTVAVMAEVPEAEAIQINTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDQ 262
Cdd:PRK05589 157 IHRLVRISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 263 RSQHKNRAKAMSVLAARLQQAEdEKRHAAE----ASERRDLvGSGDrseRIRTYNY-PQGRITDHRINLTLYRLNEVVAG 337
Cdd:PRK05589 237 RSQHSNKETAMKMLKSKLVELK-ERAHKEKiedlTGELKDM-GWGS---QIRSYVFhPYNLVKDHRTGVETSNVDSVMDG 311


                 ....*.
gi 489048336 338 DLSAII 343
Cdd:PRK05589 312 DIDNFI 317
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 50-344 1.07e-67

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 215.68  E-value: 1.07e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  50 KTFLNYKETQDDLASAEEMLkdsdpemrEMAQEEYKEAKAQILVIEDQIQVLMLPK--------DPRDNNNVFVEVRAGT 121
Cdd:PRK08787   4 KTVIGIADVLSGLADAGELL--------DLAESEQDEDTALAVIADLDKYQAHVEKlefqrmfsGQMDGANAFVDIQAGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 122 GGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFESGVHRVQRVPETESQGRVHTS 201
Cdd:PRK08787  76 GGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 202 ACTVAVMAEVPEAEAIQINTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQ 281
Cdd:PRK08787 156 FTSVFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLY 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489048336 282 QAEDEKRHAA----EASERRdlVGSGdrsERIRTYNYPQGRITDHRINLTLYRLNEVVAGDLSAIID 344
Cdd:PRK08787 236 ELEVQKRNAEkdalEATKSD--IGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVE 297
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 31-348 1.94e-61

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 199.96  E-value: 1.94e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  31 DQNRFRALSKEYSELEEIVKTFLNYKETQDDLASAEEMLKDsdpEMREMAQEEYKEAKAQILVIEDQIQVLMLPKDPRDN 110
Cdd:PRK06746   9 DQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKE---EYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYDK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 111 NNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFESGVHRVQRVP 190
Cdd:PRK06746  86 NNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRIS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 191 ETESQGRVHTSACTVAVMAEVPEAEAIQINTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDQRSQHKNRA 270
Cdd:PRK06746 166 PFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNRE 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489048336 271 KAMSVLAARLQQAEDEKRHaAEASERRDLVGSGDRSERIRTYNY-PQGRITDHRINLTLYRLNEVVAGDLSAIIDPLMQ 348
Cdd:PRK06746 246 HAMKMLKAKLYQKKLEEQQ-AELDEIRGEQKEIGWGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYLR 323
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 217-323 3.73e-61

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 191.48  E-value: 3.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  217 IQINTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAEDEKRHAAEAsER 296
Cdd:pfam00472   5 IEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKR-RI 83

                          90       100
                  ....*....|....*....|....*...
gi 489048336  297 RDLVGSGDRSERIRTYNY-PQGRITDHR 323
Cdd:pfam00472  84 KSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PCRF smart00937
This domain is found in peptide chain release factors;
66-180 5.83e-59

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 186.13  E-value: 5.83e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336    66 EEMLKDSDPEMREMAQEEYKEAKAQIL-VIEDQIQVLMLPKDPRDNNNVFVEVRAGTGGDEAAIFAGDLFRMYSRYAENK 144
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEeELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 489048336   145 KWKVEVVSTNEGEHGGYKEVIANISGEGVYGQLKFE 180
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 217-307 1.82e-35

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 126.40  E-value: 1.82e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 217 IQINTADLKVDTFRASGAGGQHVNKTDSAIRLTH------------IPTGVVVECQDQRSQHKNRAKAMSVLAARLQQAE 284
Cdd:COG1186   21 IEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEAE 100

                         90       100
                 ....*....|....*....|....*...
gi 489048336 285 DEKRHAA-----EASERRDLVGSGDRSE 307
Cdd:COG1186  101 LEPKERRatkptRGSKKRRLWGKQIRSM 128
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 113-315 1.06e-27

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 107.55  E-value: 1.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  113 VFVEVRAGTGGDEAAIFAGDLFRMYSRYAENKKWKVEVVSTNEGEH-GGYKEVIANISGEG--VYGQlKFESGVHRVQRV 189
Cdd:TIGR03072   1 ILLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVpGTLRSALVSLDGEAaaALAD-RWEGTLLWICPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336  190 PETESQGRvHTSACTVAVMAEVPEAeaiqiNTADLKVDTFRASGAGGQHVNKTDSAIRLTHIPTGVVVECQDQRSQHKNR 269
Cdd:TIGR03072  80 PYRPHHRR-KNWFIGVQRFSASEEA-----TEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANK 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 489048336  270 AKAMSVLAARLQQAEDEkRHAAEASERRDLVGSGDRSERIRTYNYP 315
Cdd:TIGR03072 154 RLATLLLAVRLADLQQE-QAAALRAERRTAHHQIERGNPVRVFKGE 198
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
217-283 1.33e-10

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 58.62  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489048336 217 IQINTADLKVDTFRASGAGGQHVNKTDSAIRL------THIPT-----------------GV-VVECQDQRSQHKNRAKA 272
Cdd:PRK09256   8 LVIPENELEWRFIRASGPGGQNVNKVSTAVELrfdiaaSSLPEfykerllalaghritkdGViVIKAQEFRSQERNREDA 87

                         90
                 ....*....|.
gi 489048336 273 MSVLAARLQQA 283
Cdd:PRK09256  88 LERLVALIREA 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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