NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489053594|ref|WP_002963781|]
View 

MULTISPECIES: DUF423 domain-containing protein [Brucella]

Protein Classification

DUF423 domain-containing protein( domain architecture ID 10006411)

DUF423 domain-containing protein, possibly an integral membrane protein similar to human transmembrane protein 256 and Bacillus subtilis membrane protein YwdK

Gene Ontology:  GO:0016020

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
12-123 3.43e-14

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


:

Pssm-ID: 441930  Cd Length: 126  Bit Score: 64.04  E-value: 3.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489053594  12 LFGTLAGLCGALGIASYAGAAHMGESHLGTIAPLLL----------AHAPALLFLSLISPVSRVVRIGGAILVVGLALFC 81
Cdd:COG2363    5 LFLILGALLGALAVALGAFGAHGLKGRLSPEALATFetavryqmyhALALLALGLLAQRLPSRLLRLAGWLFLLGILLFS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489053594  82 GDLFMRDMTGDRLFPFAAPTGGSLMILGWLCLGCSGWFSANA 123
Cdd:COG2363   85 GSLYALALTGIKLLGAITPIGGLLFILGWLLLAIAALRLKRR 126
 
Name Accession Description Interval E-value
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
12-123 3.43e-14

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 64.04  E-value: 3.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489053594  12 LFGTLAGLCGALGIASYAGAAHMGESHLGTIAPLLL----------AHAPALLFLSLISPVSRVVRIGGAILVVGLALFC 81
Cdd:COG2363    5 LFLILGALLGALAVALGAFGAHGLKGRLSPEALATFetavryqmyhALALLALGLLAQRLPSRLLRLAGWLFLLGILLFS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489053594  82 GDLFMRDMTGDRLFPFAAPTGGSLMILGWLCLGCSGWFSANA 123
Cdd:COG2363   85 GSLYALALTGIKLLGAITPIGGLLFILGWLLLAIAALRLKRR 126
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 60-103 2.63e-04

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 37.11  E-value: 2.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489053594   60 SPVSRVVRIGGAILVVGLALFCGDLFMRDMTGDRLFPFAAPTGG 103
Cdd:pfam04241  43 APRARLLNLAGWLFLAGIVLFSGSLYALALTGIKWLGPITPIGG 86
 
Name Accession Description Interval E-value
YgdD COG2363
Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];
12-123 3.43e-14

Uncharacterized membrane protein YgdD, TMEM256/DUF423 family [Function unknown];


Pssm-ID: 441930  Cd Length: 126  Bit Score: 64.04  E-value: 3.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489053594  12 LFGTLAGLCGALGIASYAGAAHMGESHLGTIAPLLL----------AHAPALLFLSLISPVSRVVRIGGAILVVGLALFC 81
Cdd:COG2363    5 LFLILGALLGALAVALGAFGAHGLKGRLSPEALATFetavryqmyhALALLALGLLAQRLPSRLLRLAGWLFLLGILLFS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489053594  82 GDLFMRDMTGDRLFPFAAPTGGSLMILGWLCLGCSGWFSANA 123
Cdd:COG2363   85 GSLYALALTGIKLLGAITPIGGLLFILGWLLLAIAALRLKRR 126
DUF423 pfam04241
Protein of unknown function (DUF423); This family of proteins with unknown function is a ...
 60-103 2.63e-04

Protein of unknown function (DUF423); This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.


Pssm-ID: 461234  Cd Length: 86  Bit Score: 37.11  E-value: 2.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 489053594   60 SPVSRVVRIGGAILVVGLALFCGDLFMRDMTGDRLFPFAAPTGG 103
Cdd:pfam04241  43 APRARLLNLAGWLFLAGIVLFSGSLYALALTGIKWLGPITPIGG 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH