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MULTISPECIES: NADP-dependent isocitrate dehydrogenase [Brucella]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10013037 )
isocitrate dehydrogenase (NADP(+)) converts isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-402
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 955.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 1 MAKIKV A NPVVELDGDEMTRIIW Q FIKDKLI H PYLDIDL K YYDL SV ENRDAT N DQVTIDAANAIK E YGVGVKCATITPDE 80
Cdd:PRK08299 1 MAKIKV K NPVVELDGDEMTRIIW K FIKDKLI L PYLDIDL E YYDL GI ENRDAT D DQVTIDAANAIK K YGVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 ARV E EF K LKKMWKSPNGTIRNILGG VI FREPIICKNVPRLVPGWT Q PI IV GRHA F GDQYRATDFK F PGKG T LT IK F V GED 160
Cdd:PRK08299 81 ARV K EF N LKKMWKSPNGTIRNILGG TV FREPIICKNVPRLVPGWT K PI VI GRHA Y GDQYRATDFK V PGKG K LT LV F T GED 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 G QT IEHEV YQA P S AGVAM A MYNLDESIR E FARASFNYGL Q R G YPVYLSTKNTILKAYDGRFKDIFQEV FD AEFK S KFE EK 240
Cdd:PRK08299 161 G EP IEHEV HDF P G AGVAM G MYNLDESIR D FARASFNYGL D R K YPVYLSTKNTILKAYDGRFKDIFQEV YE AEFK E KFE AA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K I W YEHRLIDDMVASALKW S GGYVWACKNYDGDVQSD I VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
Cdd:PRK08299 241 G I T YEHRLIDDMVASALKW E GGYVWACKNYDGDVQSD T VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 EETSTN S IASIFAWTRGLAHR A KLD N N AD L K KFA E TLEKVC VD TVESGFMTKDLALL I GPDQ P WL S T TG FLD K IDENL Q K 400
Cdd:PRK08299 321 EETSTN P IASIFAWTRGLAHR G KLD G N PE L V KFA D TLEKVC IE TVESGFMTKDLALL V GPDQ K WL T T EE FLD A IDENL E K 400
..
gi 489054151 401 A M 402
Cdd:PRK08299 401 A L 402
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-402
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 955.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 1 MAKIKV A NPVVELDGDEMTRIIW Q FIKDKLI H PYLDIDL K YYDL SV ENRDAT N DQVTIDAANAIK E YGVGVKCATITPDE 80
Cdd:PRK08299 1 MAKIKV K NPVVELDGDEMTRIIW K FIKDKLI L PYLDIDL E YYDL GI ENRDAT D DQVTIDAANAIK K YGVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 ARV E EF K LKKMWKSPNGTIRNILGG VI FREPIICKNVPRLVPGWT Q PI IV GRHA F GDQYRATDFK F PGKG T LT IK F V GED 160
Cdd:PRK08299 81 ARV K EF N LKKMWKSPNGTIRNILGG TV FREPIICKNVPRLVPGWT K PI VI GRHA Y GDQYRATDFK V PGKG K LT LV F T GED 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 G QT IEHEV YQA P S AGVAM A MYNLDESIR E FARASFNYGL Q R G YPVYLSTKNTILKAYDGRFKDIFQEV FD AEFK S KFE EK 240
Cdd:PRK08299 161 G EP IEHEV HDF P G AGVAM G MYNLDESIR D FARASFNYGL D R K YPVYLSTKNTILKAYDGRFKDIFQEV YE AEFK E KFE AA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K I W YEHRLIDDMVASALKW S GGYVWACKNYDGDVQSD I VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
Cdd:PRK08299 241 G I T YEHRLIDDMVASALKW E GGYVWACKNYDGDVQSD T VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 EETSTN S IASIFAWTRGLAHR A KLD N N AD L K KFA E TLEKVC VD TVESGFMTKDLALL I GPDQ P WL S T TG FLD K IDENL Q K 400
Cdd:PRK08299 321 EETSTN P IASIFAWTRGLAHR G KLD G N PE L V KFA D TLEKVC IE TVESGFMTKDLALL V GPDQ K WL T T EE FLD A IDENL E K 400
..
gi 489054151 401 A M 402
Cdd:PRK08299 401 A L 402
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-404
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 691.23
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 3 KIKVANPVVE L DGDEMTRIIW QF IKDKLI H PY LDI DLKYYDL S VE N RDATNDQVT I DAA N AIK E Y G VGVKCATITPDEAR 82
Cdd:TIGR00127 2 KIKVANPVVE M DGDEMTRIIW EL IKDKLI L PY VEL DLKYYDL G VE Y RDATNDQVT V DAA E AIK K Y N VGVKCATITPDEAR 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 83 VEEFKLKKMWKSPNGTIRNILGG VI FREPIICKN V PRLVPGW TQ PII V GRHAFGDQYRATDF KF PG K G T L TIKFVGE DG - 161
Cdd:TIGR00127 82 VEEFKLKKMWKSPNGTIRNILGG TV FREPIICKN I PRLVPGW EK PII I GRHAFGDQYRATDF VV PG P G K L ELVYKPK DG t 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 162 Q TIEHE VY QAP - SA GVAMAMYN L DESI RE FA RA SF NYG L QRGY P V YLSTKNTILK A YDGRFKDIFQEV FD A EF KSKFE EK 240
Cdd:TIGR00127 162 Q KVTLK VY DFE e GG GVAMAMYN T DESI EG FA HS SF QLA L EKKW P L YLSTKNTILK K YDGRFKDIFQEV YE A QY KSKFE AL 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K IWYEHRLIDDMVA S ALK WS GG YV WACKNYDGDVQSDIVAQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR QH QKG 320
Cdd:TIGR00127 242 G IWYEHRLIDDMVA Q ALK SE GG FI WACKNYDGDVQSDIVAQGFGSLGLMTSVL IC PDGKT F EAEAAHGTVTRHYR MY QKG 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 E ETSTNSIASIFAW T RGLAHRAKLDNN AD L K KFA ET LE KV C VD TVE S G F MTKDLAL LI G PDQP ---- W L S T TG F L D KID E 396
Cdd:TIGR00127 322 Q ETSTNSIASIFAW S RGLAHRAKLDNN PE L S KFA NI LE SA C IN TVE A G I MTKDLAL IL G GSPV ersa Y L N T EE F I D AVE E 401
....*...
gi 489054151 397 N L Q K AM AA 404
Cdd:TIGR00127 402 R L K K KI AA 409
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
2-400
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 558.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 2 A KIKV ANP --------- VVELD GD ---- E M TR I IW QF I KDKLIHP Y --- L DI DL K YY D LSVEN RD A T N D QVTIDA A N AIK 65
Cdd:COG0538 4 E KIKV EDG klkvpdnpi IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk R DI EW K EV D AGEKA RD E T G D WLPDET A E AIK 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 66 EYGVG V K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGVIF R E P I - IC K N VP RL V PGW - TQP I IVG R HAFG D Q Y RATD 143
Cdd:COG0538 84 EYGVG I K GPLT TP VGG --------- G W R S L N V TIR Q IL DLYVC R R P V r YF K G VP SP V KHP e KVD I VIF R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 144 F K FPGKGT L TIK F VG ED GQ ti EHE V YQA P - SA G VAMAMYN l DE SIREFA RA SFN Y G L QRG - YP V Y L ST K NT I L K AYD G R F 221
Cdd:COG0538 155 W K AGSPEA L KLI F FL ED EM -- GVT V IRF P e DS G IGIKPVS - DE GTERLV RA AIQ Y A L DNK r KS V T L VH K GN I M K FTE G A F 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 222 KD IFQ EV FDA EF KS KF ------------- EEK KI W Y EH R LI DDM VASA L KWS G G Y - V W A C KN YD GD VQ SD IV A QGF G S LG 287
Cdd:COG0538 232 KD WGY EV AEE EF GD KF itegpwekykgpk PAG KI V Y KD R IA DDM LQQI L LRP G E Y d V I A T KN LN GD YI SD AL A AQV G G LG 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 288 LMTSVLMTP DG K t V E A EA A HGT VTRH yrqhqk GEET STN SIAS I FAW T RG L A HR AK L DN nadlkkf A ETL EK VCVD T V ES 367
Cdd:COG0538 312 IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STN PGSL I LSG T MM L R HR GW L EA ------- A DLI EK AVEK T I ES 377
410 420 430
....*....|....*....|....*....|...
gi 489054151 368 G FM T K DLA L L I g PDQPW LST TG F L D K I D ENL Q K 400
Cdd:COG0538 378 G KV T Y DLA R L M - EGATE LST SE F G D A I I ENL D K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
5-376
2.26e-88
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 271.48
E-value: 2.26e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 5 K V A NPVVELD G D E MTRIIWQFI K DK L IHPY L DIDLKYY D LSVENR D A T NDQVTIDAAN A I K EYGVGVKC A TIT P D ---- E 80
Cdd:pfam00180 1 K I A VLPGDGI G P E VMAAALKVL K AA L EKAP L EFEFEER D VGGAAI D E T GEPLPDETLE A C K KADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 A R V E EF k L KKMW K SP n G TIR N ILGGVI F R e P IICKNVPRLVPGWTQ p I IVG R HAF G DQ Y RATDFKFP G K G T ltikfvg E D 160
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAKV F P - P LGDASPLKNEVEGVD - I VIV R ELT G GI Y FGIEKGIK G S G N ------- E V 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 GQTIE hevyqapsagvama M Y NL DE s I REF AR AS F NYGLQ RG - YP V YLST K NTI LK AY D g RFKD I FQ EV FD AE F kskfee 239
Cdd:pfam00180 150 AVDTK -------------- L Y SR DE - I ERI AR VA F ELARK RG r KK V TSVD K ANV LK SS D - LWRK I VT EV AK AE Y ------ 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 240 KKIWY EH R L I D DMVASAL K WSGGY - V WACK N YD GD VQ SD IVAQGF GSLGL MT S VLMTPD G k TVEA E AA HG TVTRHYRQHQ 318
Cdd:pfam00180 208 PDVEL EH Q L V D NAAMQLV K NPSQF d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI 286
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489054151 319 kgeets T N S IA S I FAWTRG L AHRAK L DNN AD L kkfaet L E KVCVDTV ESG FM T K DLA L 376
Cdd:pfam00180 287 ------ A N P IA T I LSAAMM L RYSLG L EDA AD K ------ I E AAVLKVL ESG IR T G DLA G 332
Name
Accession
Description
Interval
E-value
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-402
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 955.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 1 MAKIKV A NPVVELDGDEMTRIIW Q FIKDKLI H PYLDIDL K YYDL SV ENRDAT N DQVTIDAANAIK E YGVGVKCATITPDE 80
Cdd:PRK08299 1 MAKIKV K NPVVELDGDEMTRIIW K FIKDKLI L PYLDIDL E YYDL GI ENRDAT D DQVTIDAANAIK K YGVGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 ARV E EF K LKKMWKSPNGTIRNILGG VI FREPIICKNVPRLVPGWT Q PI IV GRHA F GDQYRATDFK F PGKG T LT IK F V GED 160
Cdd:PRK08299 81 ARV K EF N LKKMWKSPNGTIRNILGG TV FREPIICKNVPRLVPGWT K PI VI GRHA Y GDQYRATDFK V PGKG K LT LV F T GED 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 G QT IEHEV YQA P S AGVAM A MYNLDESIR E FARASFNYGL Q R G YPVYLSTKNTILKAYDGRFKDIFQEV FD AEFK S KFE EK 240
Cdd:PRK08299 161 G EP IEHEV HDF P G AGVAM G MYNLDESIR D FARASFNYGL D R K YPVYLSTKNTILKAYDGRFKDIFQEV YE AEFK E KFE AA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K I W YEHRLIDDMVASALKW S GGYVWACKNYDGDVQSD I VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
Cdd:PRK08299 241 G I T YEHRLIDDMVASALKW E GGYVWACKNYDGDVQSD T VAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 EETSTN S IASIFAWTRGLAHR A KLD N N AD L K KFA E TLEKVC VD TVESGFMTKDLALL I GPDQ P WL S T TG FLD K IDENL Q K 400
Cdd:PRK08299 321 EETSTN P IASIFAWTRGLAHR G KLD G N PE L V KFA D TLEKVC IE TVESGFMTKDLALL V GPDQ K WL T T EE FLD A IDENL E K 400
..
gi 489054151 401 A M 402
Cdd:PRK08299 401 A L 402
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-404
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 816.53
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 1 MA KIKV A NPVVELDGDEMTRIIW QF IK D KLI H PYLD IDL KYYDLS V ENRD A T N D Q VT I DAA N AIK EYG VG V KCATITPDE 80
Cdd:PTZ00435 3 GG KIKV K NPVVELDGDEMTRIIW KM IK E KLI L PYLD VPI KYYDLS I ENRD K T D D K VT V DAA E AIK KHK VG I KCATITPDE 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 ARV E EF K LKKMWKSPNGTIRNIL G G VI FREPII C KN V PRLVPGW TQ PI IV GRHAFGDQY R ATDF KFP G K G T L TIK F VGE D 160
Cdd:PTZ00435 83 ARV K EF N LKKMWKSPNGTIRNIL D G TV FREPII I KN I PRLVPGW KK PI VI GRHAFGDQY K ATDF VVD G P G K L ELV F TPA D 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 G - QTIEHE V YQAPSA GVAM A MYN L DESI RE FAR AS F N Y G L Q R GY P V YLSTKNTILK A YDGRFKDIFQE VF D A E F K S KFE E 239
Cdd:PTZ00435 163 G s EPQRVD V FDFKGG GVAM G MYN T DESI EG FAR SC F Q Y A L D R KM P L YLSTKNTILK K YDGRFKDIFQE IY D E E Y K A KFE K 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 240 KKI WYEHRLIDDMVA S A L K WS GG Y VWACKNYDGDVQSDIVAQG F GSLGLMTSVL MT PDGKTVEAEAAHGTVTRHYRQHQK 319
Cdd:PTZ00435 243 AGL WYEHRLIDDMVA Q A I K SE GG F VWACKNYDGDVQSDIVAQG Y GSLGLMTSVL VC PDGKTVEAEAAHGTVTRHYRQHQK 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 320 G E ETSTNSIASIFAWTRGLAHRAKLDNN AD L K KF AET LE KV C VD T V E S GFMTKDLA LLI - G PDQ ---- PW L S T TG F L DK I 394
Cdd:PTZ00435 323 G K ETSTNSIASIFAWTRGLAHRAKLDNN QE L V KF CQA LE RS C IE T I E A GFMTKDLA ICV h G SSK vtrs DY L N T EE F I DK V 402
410
....*....|
gi 489054151 395 D E N L Q K AMA A 404
Cdd:PTZ00435 403 A E K L K K KLG A 412
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
3-400
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 704.33
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 3 K IKV A NP V VE L DGDEMTR I IWQ F IKDKLI H PYLD I D L KY Y DL SVE NRDAT N D Q VT IDA A N A IKE Y G V GV KCATITPDEAR 82
Cdd:PLN03065 73 R IKV Q NP I VE M DGDEMTR V IWQ M IKDKLI F PYLD L D I KY F DL GIL NRDAT D D K VT VES A E A TLK Y N V AI KCATITPDEAR 152
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 83 V E EF K LK K MW K SPNGTIRNIL G G VI FREPI I CKN V PRLVPGW TQ PI IV GRHAFGDQYRATD FKFP G K G T L TIK FV G EDG Q 162
Cdd:PLN03065 153 V K EF G LK S MW R SPNGTIRNIL N G TV FREPI L CKN I PRLVPGW KK PI CI GRHAFGDQYRATD TVIK G P G K L KMV FV P EDG N 232
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 163 T - I E HE VY QAPSA GVA M AMYN L DESIR E FA RA S FNYG LQ RGY P V YLSTKNTILK A YDGRFKDIFQEV FDAEF K S KFEE KK 241
Cdd:PLN03065 233 A p V E LD VY DFKGP GVA L AMYN V DESIR A FA ES S MAMA LQ KKW P L YLSTKNTILK K YDGRFKDIFQEV YEEQW K Q KFEE HS 312
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 242 IWYEHRLIDDMVA S A L K WS GGYVWACKNYDGDVQSD IV AQGFGSLGLMTSVL MTP DGKT V EAEAAHGTVTRH Y R Q HQKG E 321
Cdd:PLN03065 313 IWYEHRLIDDMVA Y A V K SE GGYVWACKNYDGDVQSD LL AQGFGSLGLMTSVL LSS DGKT L EAEAAHGTVTRH F R L HQKG Q 392
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 322 ETSTNSIASIFAWTRGL A HRAKLD N N AD L KK F AET LE KV C VD TVESG F MTKDLA L LI - GP D --- QPW L S T TG F L D KIDEN 397
Cdd:PLN03065 393 ETSTNSIASIFAWTRGL E HRAKLD K N EE L LD F VHK LE SA C IE TVESG K MTKDLA I LI h GP K vsr EFY L N T EE F I D AVAQT 472
...
gi 489054151 398 L QK 400
Cdd:PLN03065 473 L AT 475
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-404
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 691.23
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 3 KIKVANPVVE L DGDEMTRIIW QF IKDKLI H PY LDI DLKYYDL S VE N RDATNDQVT I DAA N AIK E Y G VGVKCATITPDEAR 82
Cdd:TIGR00127 2 KIKVANPVVE M DGDEMTRIIW EL IKDKLI L PY VEL DLKYYDL G VE Y RDATNDQVT V DAA E AIK K Y N VGVKCATITPDEAR 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 83 VEEFKLKKMWKSPNGTIRNILGG VI FREPIICKN V PRLVPGW TQ PII V GRHAFGDQYRATDF KF PG K G T L TIKFVGE DG - 161
Cdd:TIGR00127 82 VEEFKLKKMWKSPNGTIRNILGG TV FREPIICKN I PRLVPGW EK PII I GRHAFGDQYRATDF VV PG P G K L ELVYKPK DG t 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 162 Q TIEHE VY QAP - SA GVAMAMYN L DESI RE FA RA SF NYG L QRGY P V YLSTKNTILK A YDGRFKDIFQEV FD A EF KSKFE EK 240
Cdd:TIGR00127 162 Q KVTLK VY DFE e GG GVAMAMYN T DESI EG FA HS SF QLA L EKKW P L YLSTKNTILK K YDGRFKDIFQEV YE A QY KSKFE AL 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K IWYEHRLIDDMVA S ALK WS GG YV WACKNYDGDVQSDIVAQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR QH QKG 320
Cdd:TIGR00127 242 G IWYEHRLIDDMVA Q ALK SE GG FI WACKNYDGDVQSDIVAQGFGSLGLMTSVL IC PDGKT F EAEAAHGTVTRHYR MY QKG 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 E ETSTNSIASIFAW T RGLAHRAKLDNN AD L K KFA ET LE KV C VD TVE S G F MTKDLAL LI G PDQP ---- W L S T TG F L D KID E 396
Cdd:TIGR00127 322 Q ETSTNSIASIFAW S RGLAHRAKLDNN PE L S KFA NI LE SA C IN TVE A G I MTKDLAL IL G GSPV ersa Y L N T EE F I D AVE E 401
....*...
gi 489054151 397 N L Q K AM AA 404
Cdd:TIGR00127 402 R L K K KI AA 409
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
3-399
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 687.72
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 3 KIKVANP V VE L DGDEMTR I IW QF IKDKLI H P Y LD I D L KY Y DL SVE NRDAT N D Q VT IDA A N A IKE Y G V GV KCATITPDEAR 82
Cdd:PLN00103 5 KIKVANP I VE M DGDEMTR V IW KS IKDKLI F P F LD L D I KY F DL GLP NRDAT D D K VT VES A E A TLK Y N V AI KCATITPDEAR 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 83 V E EF K LK K MWKSPNGTIRNIL G G VI FREPIICKN V PRLVPGWT Q PI IV GRHAFGDQYRATD FKFP G K G T L TIK FV G E D - G 161
Cdd:PLN00103 85 V K EF G LK Q MWKSPNGTIRNIL N G TV FREPIICKN I PRLVPGWT K PI CI GRHAFGDQYRATD AVIK G P G K L KLV FV P E G k D 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 162 QTI E H EVY QAPS A - GVA MA MYN L DESIR E FA R AS F N YGL Q RGY P V YLSTKNTILK A YDGRFKDIFQEV FD A EF KSKFE EK 240
Cdd:PLN00103 165 EKT E L EVY NFTG A g GVA LS MYN T DESIR A FA E AS M N TAY Q KKW P L YLSTKNTILK K YDGRFKDIFQEV YE A QW KSKFE AA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 241 K IWYEHRLIDDMVA S ALK WS GGYVWACKNYDGDVQSD IV AQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR Q HQKG 320
Cdd:PLN00103 245 G IWYEHRLIDDMVA Y ALK SE GGYVWACKNYDGDVQSD FL AQGFGSLGLMTSVL VC PDGKT I EAEAAHGTVTRHYR V HQKG 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 321 E ETSTNSIASIFAW T RGLAHRAKLD N NA D L KK F A E T LE KV CV D TVESG F MTKDLALLI - GP DQP --- W L S T TG F L D KID E 396
Cdd:PLN00103 325 G ETSTNSIASIFAW S RGLAHRAKLD G NA R L LD F T E K LE AA CV G TVESG K MTKDLALLI h GP KVS rdq Y L N T EE F I D AVA E 404
...
gi 489054151 397 N L Q 399
Cdd:PLN00103 405 E L K 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
2-400
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 558.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 2 A KIKV ANP --------- VVELD GD ---- E M TR I IW QF I KDKLIHP Y --- L DI DL K YY D LSVEN RD A T N D QVTIDA A N AIK 65
Cdd:COG0538 4 E KIKV EDG klkvpdnpi IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk R DI EW K EV D AGEKA RD E T G D WLPDET A E AIK 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 66 EYGVG V K CATI TP DEA rveefklkk M W K S P N G TIR N IL GGVIF R E P I - IC K N VP RL V PGW - TQP I IVG R HAFG D Q Y RATD 143
Cdd:COG0538 84 EYGVG I K GPLT TP VGG --------- G W R S L N V TIR Q IL DLYVC R R P V r YF K G VP SP V KHP e KVD I VIF R ENTE D I Y AGIE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 144 F K FPGKGT L TIK F VG ED GQ ti EHE V YQA P - SA G VAMAMYN l DE SIREFA RA SFN Y G L QRG - YP V Y L ST K NT I L K AYD G R F 221
Cdd:COG0538 155 W K AGSPEA L KLI F FL ED EM -- GVT V IRF P e DS G IGIKPVS - DE GTERLV RA AIQ Y A L DNK r KS V T L VH K GN I M K FTE G A F 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 222 KD IFQ EV FDA EF KS KF ------------- EEK KI W Y EH R LI DDM VASA L KWS G G Y - V W A C KN YD GD VQ SD IV A QGF G S LG 287
Cdd:COG0538 232 KD WGY EV AEE EF GD KF itegpwekykgpk PAG KI V Y KD R IA DDM LQQI L LRP G E Y d V I A T KN LN GD YI SD AL A AQV G G LG 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 288 LMTSVLMTP DG K t V E A EA A HGT VTRH yrqhqk GEET STN SIAS I FAW T RG L A HR AK L DN nadlkkf A ETL EK VCVD T V ES 367
Cdd:COG0538 312 IAPGANIGD DG G - A E F EA T HGT APKY ------ AGKD STN PGSL I LSG T MM L R HR GW L EA ------- A DLI EK AVEK T I ES 377
410 420 430
....*....|....*....|....*....|...
gi 489054151 368 G FM T K DLA L L I g PDQPW LST TG F L D K I D ENL Q K 400
Cdd:COG0538 378 G KV T Y DLA R L M - EGATE LST SE F G D A I I ENL D K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
5-376
2.26e-88
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 271.48
E-value: 2.26e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 5 K V A NPVVELD G D E MTRIIWQFI K DK L IHPY L DIDLKYY D LSVENR D A T NDQVTIDAAN A I K EYGVGVKC A TIT P D ---- E 80
Cdd:pfam00180 1 K I A VLPGDGI G P E VMAAALKVL K AA L EKAP L EFEFEER D VGGAAI D E T GEPLPDETLE A C K KADAVLLG A VGG P K wdpa G 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 81 A R V E EF k L KKMW K SP n G TIR N ILGGVI F R e P IICKNVPRLVPGWTQ p I IVG R HAF G DQ Y RATDFKFP G K G T ltikfvg E D 160
Cdd:pfam00180 81 V R P E NG - L LALR K EL - G LFA N LRPAKV F P - P LGDASPLKNEVEGVD - I VIV R ELT G GI Y FGIEKGIK G S G N ------- E V 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 161 GQTIE hevyqapsagvama M Y NL DE s I REF AR AS F NYGLQ RG - YP V YLST K NTI LK AY D g RFKD I FQ EV FD AE F kskfee 239
Cdd:pfam00180 150 AVDTK -------------- L Y SR DE - I ERI AR VA F ELARK RG r KK V TSVD K ANV LK SS D - LWRK I VT EV AK AE Y ------ 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 240 KKIWY EH R L I D DMVASAL K WSGGY - V WACK N YD GD VQ SD IVAQGF GSLGL MT S VLMTPD G k TVEA E AA HG TVTRHYRQHQ 318
Cdd:pfam00180 208 PDVEL EH Q L V D NAAMQLV K NPSQF d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI 286
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489054151 319 kgeets T N S IA S I FAWTRG L AHRAK L DNN AD L kkfaet L E KVCVDTV ESG FM T K DLA L 376
Cdd:pfam00180 287 ------ A N P IA T I LSAAMM L RYSLG L EDA AD K ------ I E AAVLKVL ESG IR T G DLA G 332
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
10-398
2.94e-57
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 192.56
E-value: 2.94e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 10 V V ELD G D EMTR IIWQF I KD K L I H P YL D ID - LKYY DL SVE NRD A T N DQV TI D AAN A IKEYGVGV K CA TITP DEAR V EEFK L 88
Cdd:PLN00096 1 M V YVA G E EMTR YTMDL I LA K W I E P HV D TS a WEFF DL RAK NRD D T E DQV LR D VIE A GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 89 KK M W K SPNG TI R NILG G V - I F R EP I ICKN V PR lvp G WTQ P IIVG RHA F G DQ Y R A t DF K FP GKGTL TIK FV G E D - G QT I EH 166
Cdd:PLN00096 81 KK A W G SPNG AM R RGWN G I t I S R DT I HIDG V EL --- G YKK P VFFE RHA V G GE Y S A - GY K IV GKGTL VTT FV P E E g G KP I VV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 167 EVYQAPSAGV A MAM Y - N LDESIREF AR AS F NYG L QR G YPV Y LS TK N T IL K a YDGR F KD I FQE VFD A EFKSKF EE K KIWYE 245
Cdd:PLN00096 157 DDRTITDDLN A VVT Y h N PLDNVHHL AR IF F GRC L DA G IVP Y VV TK K T VF K - WQEP F WE I MKK VFD E EFKSKF VD K GVMKS 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 246 ----- H R L I D DMVASALK W S - GG YVW A CK NYDGDV QS D IV AQ GFG S L G LM TS V L MTP D GKTV --- E A EA A HGTVT RHYRQ 316
Cdd:PLN00096 236 gdelv H L L S D AATMKLVV W T d GG FGM A AH NYDGDV LT D EL AQ VHK S P G FI TS N L VGV D ENGT lik E F EA S HGTVT DMDEA 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 317 HQK GEETS T N SIASIFAWTRGLA H R A KLDNNAD - LKK F AET L EK V CVDTVES G FM T K DL A lli G PDQ pw L S T TG F L D KID 395
Cdd:PLN00096 316 RLR GEETS L N PLGMVEGLIGAMN H A A DVHGGKE r VHP F TAK L RA V IHKLFRE G RG T R DL C --- G AGG -- L T T EQ F I D AVA 390
...
gi 489054151 396 E N L 398
Cdd:PLN00096 391 E E L 393
PLN00118
PLN00118 isocitrate dehydrogenase (NAD+)
52-309
2.35e-04
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062
Cd Length: 372
Bit Score: 42.94
E-value: 2.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 52 T NDQV T IDAANAIKEYG VG V K CATI TP dearveefk LK K MWK S P N G T I R NI LG GVIFRE P ii C KNV P rlvpgwtqpiivg 131
Cdd:PLN00118 86 T GSFL T WESLESVRRNK VG L K GPMA TP --------- IG K GHR S L N L T L R KE LG LYANVR P -- C YSL P ------------- 141
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 132 rh AFGDQ Y RAT D F kfpgkgt L TI KFVG E - DGQTI EH E V YQAPSAGVAMAMYNLDESIR E F A ras F N Y GLQR G YP - V YLST 209
Cdd:PLN00118 142 -- GYKTR Y DDV D L ------- V TI RENT E g EYSGL EH Q V VRGVVESLKIITRQASLRVA E Y A --- F H Y AKTH G RK r V SAIH 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 210 K NT I L K AY DG R F KDIFQ EV fdaef KS K FE E kk I W YE HRL ID DMVASAL K WSGGY - V WACK N YD GD VQ SD IV A QGF G S LGL 288
Cdd:PLN00118 210 K AN I M K KT DG L F LKCCR EV ----- AE K YP E -- I V YE EVI ID NCCMMLV K NPALF d V LVMP N LY GD II SD LC A GLI G G LGL 282
250 260
....*....|....*....|.
gi 489054151 289 MT S VLMTPD G KTV e AEA A HG T 309
Cdd:PLN00118 283 TP S CNIGEN G LAL - AEA V HG S 302
PRK06451
PRK06451 NADP-dependent isocitrate dehydrogenase;
52-313
2.40e-03
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803
Cd Length: 412
Bit Score: 39.81
E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 52 T NDQVTIDAANA I KE Y G V GV K CATI TP dearveefk LK K M WKS P N GT IR NI L GGVIFRE P I icknvp RLV PG WTQ P I --- 128
Cdd:PRK06451 75 T GNRFPKESEEL I EK Y R V LL K GPLE TP --------- IG K G WKS I N VA IR LM L DLYANIR P V ------ KYI PG IES P L knp 139
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 129 ----- I VG R HAFG D Q YR ATDFKFPGKGTLT I - K F VGE dgqti E HE V YQAPSA G VAMAMYNLDESI R e F AR ASFN Y GLQRG 202
Cdd:PRK06451 140 ekidl I IF R ENTD D L YR GIEYPYDSEEAKK I r D F LRK ----- E LG V EVEDDT G IGIKLISKFKTQ R - I AR MAIK Y AIDHK 213
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054151 203 Y - P V YLST K NTIL K AYD G R F KDIFQ EV FDA EF K -------------- SKFEEK K IWYEH R LI D D M VASALKWSGG Y - VWA 266
Cdd:PRK06451 214 R k K V TIMH K GNVM K YTE G A F REWAY EV ALK EF R dyvvteeevtknyn GVPPSG K VIIND R IA D N M FQQIIIRPDE Y d IIL 293
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489054151 267 CK N YD GD VQ SD IVAQGF G SL G LMTSVLMTPD G KTV ea EA A HGT VTRH 313
Cdd:PRK06451 294 AP N VN GD YI SD AAGALV G NI G MLGGANIGDT G GMF -- EA I HGT APKY 338
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
