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Conserved domains on  [gi|489054667|ref|WP_002964834|]
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MULTISPECIES: pyruvate kinase [Brucella]

Protein Classification

pyruvate kinase( domain architecture ID 11482148)

pyruvate kinase catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of ATP

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK06247 PRK06247
pyruvate kinase; Provisional
1-476 0e+00

pyruvate kinase; Provisional


:

Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 869.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   1 MKRNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKF 80
Cdd:PRK06247   1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  81 KDGKVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVS 160
Cdd:PRK06247  81 ADGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 161 LPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGKVGLMSKIEKPQAVTRLYEIIELSDALMVA 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 241 RGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVE 320
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 321 AVATMNRIAEQVEREPTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALSP 400
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489054667 401 VVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYIGADGKS 476
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDDVS 476
 
Name Accession Description Interval E-value
PRK06247 PRK06247
pyruvate kinase; Provisional
1-476 0e+00

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 869.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   1 MKRNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKF 80
Cdd:PRK06247   1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  81 KDGKVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVS 160
Cdd:PRK06247  81 ADGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 161 LPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGKVGLMSKIEKPQAVTRLYEIIELSDALMVA 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 241 RGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVE 320
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 321 AVATMNRIAEQVEREPTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALSP 400
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489054667 401 VVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYIGADGKS 476
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDDVS 476
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
3-470 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 742.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   3 RNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKD 82
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  83 GKVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLP 162
Cdd:COG0469   81 GPVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 163 DTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSR---GKVGLMSKIEKPQAVTRLYEIIELSDALMV 239
Cdd:COG0469  161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 240 ARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPV 319
Cdd:COG0469  241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 320 EAVATMNRIAEQVEREPTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALS 399
Cdd:COG0469  321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489054667 400 PVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYI 470
Cdd:COG0469  401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
5-467 5.14e-175

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 499.50  E-value: 5.14e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667    5 RKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDGK 84
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   85 VDLVPGQTFTL--DNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLP 162
Cdd:TIGR01064  81 VKLKKGDKVIIttDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  163 DTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKV----SRGKVGLMSKIEKPQAVTRLYEIIELSDALM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVlgekGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  239 VARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  319 VEAVATMNRIAEQVEREPTYSTII-DAQRAMPEPTG-ADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPII 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFnDRKNSDPKPSTiTEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489054667  397 ALSPVVDTARKLSLVWGLHCVVTDD-AHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRI 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
4-470 7.37e-152

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 440.98  E-value: 7.37e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   4 NRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDG 83
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  84 -KVDLVPGQTFTLDNNEA--LGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDG-KSIRCKVVSGTRISDRKGV 159
Cdd:cd00288   81 kDISLKAGDKFLVTTDPAakKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRKGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 160 SLPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGK---VGLMSKIEKPQAVTRLYEIIELSDA 236
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKgkdIKIIAKIENQEGVNNFDEILEASDG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 237 LMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQ 316
Cdd:cd00288  241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 317 YPVEAVATMNRIAEQVEREPTYSTIIDAQR-AMPEPTGA-DAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTP 394
Cdd:cd00288  321 YPVEAVKAMARICLEAEKALSHRVLFNEMRrLTPRPTSTtEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 395 IIALSPVVDTARKLSLVWGLHCVVTD-----DAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTpGATNMLRIAY 469
Cdd:cd00288  401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILT 479

                 .
gi 489054667 470 I 470
Cdd:cd00288  480 V 480
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
4-335 2.50e-117

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 348.20  E-value: 2.50e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667    4 NRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDG 83
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   84 KVD--LVPGQTFTLDNNEAL---GDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDG-KSIRCKVVSGTRISDRK 157
Cdd:pfam00224  81 KKDieLKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDdKTLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  158 GVSLPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKV--SRGK-VGLMSKIEKPQAVTRLYEIIELS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVlgEAGKnIQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  235 DALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESAS 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330       340
                  ....*....|....*....|.
gi 489054667  315 GQYPVEAVATMNRIAEQVERE 335
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKA 341
 
Name Accession Description Interval E-value
PRK06247 PRK06247
pyruvate kinase; Provisional
1-476 0e+00

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 869.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   1 MKRNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKF 80
Cdd:PRK06247   1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  81 KDGKVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVS 160
Cdd:PRK06247  81 ADGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 161 LPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGKVGLMSKIEKPQAVTRLYEIIELSDALMVA 240
Cdd:PRK06247 161 LPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 241 RGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVE 320
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 321 AVATMNRIAEQVEREPTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALSP 400
Cdd:PRK06247 321 AVRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTP 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489054667 401 VVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYIGADGKS 476
Cdd:PRK06247 401 NPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDDVS 476
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
3-470 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 742.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   3 RNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKD 82
Cdd:COG0469    1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  83 GKVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLP 162
Cdd:COG0469   81 GPVELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 163 DTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSR---GKVGLMSKIEKPQAVTRLYEIIELSDALMV 239
Cdd:COG0469  161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 240 ARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPV 319
Cdd:COG0469  241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 320 EAVATMNRIAEQVEREPTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALS 399
Cdd:COG0469  321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489054667 400 PVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYI 470
Cdd:COG0469  401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
2-460 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 517.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   2 KRNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFK 81
Cdd:PRK05826   1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  82 DGKVDLVPGQTFTLD-NNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVS 160
Cdd:PRK05826  81 EGKITLKTGDKFTLDtDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 161 LPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSR----GKVGLMSKIEKPQAVTRLYEIIELSDA 236
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLReagcPHAKIIAKIERAEAVDNIDEIIEASDG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 237 LMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQ 316
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 317 YPVEAVATMNRIAEQVEREPTYStiIDAQRA-MPEPTGADAISLAARQIAETLKLS-AIVTYTASGTTGLRAARERPRTP 394
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFSIN--LSKHRLdRQFDRIDEAIAMSAMYAANHLKGVkAIVALTESGRTARLISRFRPGAP 398
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489054667 395 IIALSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPG 460
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
5-467 5.14e-175

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 499.50  E-value: 5.14e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667    5 RKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDGK 84
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   85 VDLVPGQTFTL--DNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLP 162
Cdd:TIGR01064  81 VKLKKGDKVIIttDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  163 DTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKV----SRGKVGLMSKIEKPQAVTRLYEIIELSDALM 238
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVlgekGAKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  239 VARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYP 318
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  319 VEAVATMNRIAEQVEREPTYSTII-DAQRAMPEPTG-ADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPII 396
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFnDRKNSDPKPSTiTEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489054667  397 ALSPVVDTARKLSLVWGLHCVVTDD-AHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRI 467
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK06354 PRK06354
pyruvate kinase; Provisional
4-472 3.12e-168

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 486.74  E-value: 3.12e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   4 NRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDG 83
Cdd:PRK06354   7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  84 KVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDG--KSIRCKVVSGTRISDRKGVSL 161
Cdd:PRK06354  87 PIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKadGELHCKVLVGGVLSNKKGVNF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 162 PDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGKVG----LMSKIEKPQAVTRLYEIIELSDAL 237
Cdd:PRK06354 167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGkhipIIAKIEKQEAIDNIDAILELCDGL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 238 MVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQY 317
Cdd:PRK06354 247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 318 PVEAVATMNRIAEQVEREPTYSTiIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIA 397
Cdd:PRK06354 327 PVEAVQTMATIAVRIEKDLPYRD-ILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILA 405
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489054667 398 LSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYIGA 472
Cdd:PRK06354 406 VTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
4-470 7.37e-152

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 440.98  E-value: 7.37e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   4 NRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDG 83
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  84 -KVDLVPGQTFTLDNNEA--LGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDG-KSIRCKVVSGTRISDRKGV 159
Cdd:cd00288   81 kDISLKAGDKFLVTTDPAakKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDdKTLVCEVLNGGVLGSRKGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 160 SLPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGK---VGLMSKIEKPQAVTRLYEIIELSDA 236
Cdd:cd00288  161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKgkdIKIIAKIENQEGVNNFDEILEASDG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 237 LMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQ 316
Cdd:cd00288  241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 317 YPVEAVATMNRIAEQVEREPTYSTIIDAQR-AMPEPTGA-DAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTP 394
Cdd:cd00288  321 YPVEAVKAMARICLEAEKALSHRVLFNEMRrLTPRPTSTtEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 395 IIALSPVVDTARKLSLVWGLHCVVTD-----DAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTpGATNMLRIAY 469
Cdd:cd00288  401 IIAVTRNEQTARQLHLYRGVYPVLFEepkpgWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILT 479

                 .
gi 489054667 470 I 470
Cdd:cd00288  480 V 480
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
4-335 2.50e-117

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 348.20  E-value: 2.50e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667    4 NRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDG 83
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   84 KVD--LVPGQTFTLDNNEAL---GDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDG-KSIRCKVVSGTRISDRK 157
Cdd:pfam00224  81 KKDieLKAGDEMIVSTDAKYkgaCDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDdKTLVVEVLNGGVIGSRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  158 GVSLPDTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKV--SRGK-VGLMSKIEKPQAVTRLYEIIELS 234
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVlgEAGKnIQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  235 DALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESAS 314
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330       340
                  ....*....|....*....|.
gi 489054667  315 GQYPVEAVATMNRIAEQVERE 335
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKA 341
PRK09206 PRK09206
pyruvate kinase PykF;
5-463 3.22e-117

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 352.05  E-value: 3.22e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   5 RKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDGK 84
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  85 -VDLVPGQTFTLDNNEA-LGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLP 162
Cdd:PRK09206  82 dVSLKAGQTFTFTTDKSvVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 163 DTTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGKVG----LMSKIEKPQAVTRLYEIIELSDALM 238
Cdd:PRK09206 162 GVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGeniqIISKIENQEGLNNFDEILEASDGIM 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 239 VARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYP 318
Cdd:PRK09206 242 VARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYP 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 319 VEAVATMNRIAEQVERepTYSTIIDAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGttglRAARE-R---PRTP 394
Cdd:PRK09206 322 LEAVSIMATICERTDR--VMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGG----KSARSvRkyfPDAT 395
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489054667 395 IIALSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAG--VPFGTpgaTN 463
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGalVPSGT---TN 463
PTZ00066 PTZ00066
pyruvate kinase; Provisional
3-467 1.94e-99

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 307.84  E-value: 1.94e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   3 RNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKElgRP---IGILADLQGPKLRVGK 79
Cdd:PTZ00066  36 RQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKA--RPnanLGILLDTKGPEIRTGF 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  80 FKDGK-VDLVPGQTFTLDNN-EALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRK 157
Cdd:PTZ00066 114 LKNHKpITLKEGQTLKITTDyTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERK 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 158 GVSLPDTTLGVGALTEKDRCD-LDAVLKEEIDWVALSFIQRPEDLAEVRKV--SRGK-VGLMSKIEKPQAVTRLYEIIEL 233
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLlgERGRhIKIIPKIENIEGLINFDEILAE 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 234 SDALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESA 313
Cdd:PTZ00066 274 SDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETA 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 314 SGQYPVEAVATMNRIAEQVEREPTYSTIIDA-QRAMPEP-TGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERP 391
Cdd:PTZ00066 354 NGKFPVEAVNIMAKICFEAETCIDYRVLYHAiHLAVPTPvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRP 433
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489054667 392 RTPIIALSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRI 467
Cdd:PTZ00066 434 SCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
PLN02461 PLN02461
Probable pyruvate kinase
1-449 5.23e-94

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 293.81  E-value: 5.23e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   1 MKRNRKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKF 80
Cdd:PLN02461  17 GLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  81 KDGK-VDLVPGQTFTLDNN-EALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKS--IRCKVVSGTRISDR 156
Cdd:PLN02461  97 KDGKpVQLKQGQEITITTDySIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAgtVRCRCENSAMLGER 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 157 KGVSLPDTTLGVGALTEKDRCD-LDAVLKEEIDWVALSFIQRPEDLAEVRKV--SRGK-VGLMSKIEKPQAVTRLYEIIE 232
Cdd:PLN02461 177 KNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVlgEHAKsILLISKVENQEGLDNFDDILA 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 233 LSDALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAES 312
Cdd:PLN02461 257 ESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGET 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 313 ASGQYPVEAVATMNRIAEQVEREPTYSTI---IDAQRAMPEPTGADAISLAARQiAETLKLSAIVTYTASGTTGLRAARE 389
Cdd:PLN02461 337 AAGAYPELAVKTMARICREAEASLDYGALfkeIMRSAPLPMSPLESLASSAVRT-ANKVKASLIVVLTRGGTTARLVAKY 415
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489054667 390 RPRTPIIALS-PVVDT------------ARKLSLVWGLHCVVTD------DAHDLEDMVNHACEIVFHEEFGKAGDRVI 449
Cdd:PLN02461 416 RPAVPILSVVvPEITTdsfdwscsdeapARHSLIYRGLIPVLAEgsakatDSESTEEILEAAIEHAKKKGLCKPGDSVV 494
PTZ00300 PTZ00300
pyruvate kinase; Provisional
33-450 1.23e-91

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 286.18  E-value: 1.23e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  33 VFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDGKVDLVPGQTFTLDNNEALGD---ETRVFL 109
Cdd:PTZ00300   3 VARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFADkgtKDKFYI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 110 PHPEILEAVEPGHRLLIDDGKLHL-VAEACDGKSIRCKVVSGTRISDRKGVSLPDTTLGVGALTEKDRCDLDAVLKEEID 188
Cdd:PTZ00300  83 DYQNLSKVVRPGGYIYIDDGILILhVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 189 WVALSFIQRPEDLAEVRKV--SRGK-VGLMSKIEKPQAVTRLYEIIELSDALMVARGDLGVEVPLENVPGIQKQITRKAR 265
Cdd:PTZ00300 163 MIFASFIRSAEQVGEVRKAlgAKGGdIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCN 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 266 RAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVEAVATMNRI---AEQVEREPTYSTII 342
Cdd:PTZ00300 243 VAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARIcleAQSAVNEYVFFNSI 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 343 DAQRAMPEPTGADAISLAARQIAETlKLSAIVTYTASGTTGLRAARERPRTPIIALSPVVDTARKLSLVWGLHCVVTDD- 421
Cdd:PTZ00300 323 KKLQPIPMSAEEAVCSSAVNSVYET-KAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDAe 401
                        410       420       430
                 ....*....|....*....|....*....|...
gi 489054667 422 --AHD--LEDMVNHACEIVFHEEFGKAGDRVII 450
Cdd:PTZ00300 402 rlGHDegKEQRVAMGVGFAKSKGYVQSGDLMVV 434
PRK06739 PRK06739
pyruvate kinase; Validated
10-333 5.59e-87

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 270.66  E-value: 5.59e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  10 LATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNvekeLGRPIGILADLQGPKLRVGKFKDGKVDLVP 89
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  90 GQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLPDTTLGVG 169
Cdd:PRK06739  82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 170 ALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVRKVSRGK----VGLMSKIEKPQAVTRLYEIIELSDALMVARGDLG 245
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYketsPNLIAKIETMEAIENFQDICKEADGIMIARGDLG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 246 VEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVEAVATM 325
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTL 321

                 ....*...
gi 489054667 326 NRIAEQVE 333
Cdd:PRK06739 322 RLVSEFAE 329
PLN02623 PLN02623
pyruvate kinase
5-450 2.94e-80

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 260.25  E-value: 2.94e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   5 RKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKE-LGRPIGILADLQGPKLRVGKFKDg 83
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQsKDNVIAIMLDTKGPEVRSGDLPQ- 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  84 KVDLVPGQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVSGTRISDRKGVSLPD 163
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 164 TTLGVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEVR---KVSRGKVGLMSKIEKPQAVTRLYEIIELSDALMVA 240
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKdylKSCNADIHVIVKIESADSIPNLHSIITASDGAMVA 348
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 241 RGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVE 320
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 321 AVATMNRIAEQVERE-PTYSTIIDAQRAMPEPTGaDAISLAARQIAETLKlSAIVTYTASGTTGLRAARERPRTPIIALS 399
Cdd:PLN02623 429 AVKVMHTVALRTEATlPEGTTPPNLGQAFKNHMS-EMFAFHATMMANTLG-TSIIVFTRTGFMAILLSHYRPSGTIFAFT 506
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489054667 400 PVVDTARKLSLVWG---LHCVVTDDAhdlEDMVNHACEIVFHEEFGKAGDRVII 450
Cdd:PLN02623 507 NEKRIQQRLALYQGvcpIYMQFSDDA---EETFARALSLLLNKGMVKEGEEVAL 557
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
5-450 1.64e-77

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 250.82  E-value: 1.64e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   5 RKVKILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVG------ 78
Cdd:PLN02762  25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGdlggas 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  79 --KFKDGKVdlvpgQTFTLDNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHL-VAEACdGKSIRCKVVSgtrisd 155
Cdd:PLN02762 105 saKAEDGEE-----WTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKI-GPDVKCKCTD------ 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 156 rKGVSLPDTTL--------------GVGALTEKDRCDLDAVLKEEIDWVALSFIQRPEDLAEV-----RKVSRGKVGLMS 216
Cdd:PLN02762 173 -PGLLLPRANLtfwrdgslvrernaMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLksyiaARSRDSDIGVIA 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 217 KIEKPQAVTRLYEIIELSDALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVA 296
Cdd:PLN02762 252 KIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVS 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 297 TAVFEGADAIMLSAESASGQYPVEAVATMNRIAEQVEReptYSTIIDAQRAMPEPTGADA--------ISLAARQIAETL 368
Cdd:PLN02762 332 EAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMEL---WSREEKRHEALELPQLSSSlsdriseeICNSAAKMANNL 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 369 KLSAIVTYTASGTTGLRAARERPRTPIIALSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACEIVFHEEFGKAGDRV 448
Cdd:PLN02762 409 GVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLV 488

                 ..
gi 489054667 449 II 450
Cdd:PLN02762 489 IA 490
PRK08187 PRK08187
pyruvate kinase; Validated
4-328 3.90e-65

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 217.96  E-value: 3.90e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   4 NRKVKILATL-GPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKF-- 80
Cdd:PRK08187 132 ARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVag 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  81 KDGKVDLVPGQTFTL----DNNEALGDETRVFLPHPEILEAVEPGHRLLIDDGKLHLVAEACDGKSIRCKVVS----GTR 152
Cdd:PRK08187 212 PLGKTRLYTGDRLALvaqgPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHarpkGLK 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 153 ISDRKGVSLPDTTLGVGALTEKDRCDLDAVLkEEIDWVALSFIQRPED-------LAEVRKVSRGKVGLMSKIEKPQAVT 225
Cdd:PRK08187 292 LKPEKGLNFPDTALDLPALTEKDRADLDFVA-RHADLVGYSFVQSPGDvealqaaLAARRPDDWRKLGLVLKIETPRAVA 370
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 226 RLYEII-----ELSDALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAvf 300
Cdd:PRK08187 371 NLPELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA-- 448
                        330       340
                 ....*....|....*....|....*...
gi 489054667 301 EGADAIMLSaesaSGQYPVEAVATMNRI 328
Cdd:PRK08187 449 ARAECVMLN----KGPYLVEAVTFLDDL 472
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
263-472 8.26e-56

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 188.57  E-value: 8.26e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 263 KARRAGKPVVVATQMLESMITAPVPTRAEVSDVATAVFEGADAIMLSAESASGQYPVEAVATMNRIAEQVEREPTYSTII 342
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 343 DAQRAMPEPTGADAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALSPVVDTARKLSLVWGLHCVVTDDA 422
Cdd:COG3848   81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 489054667 423 HDLEDMVNHACEIVFHEEFGKAGDRVIITAGVPFGTPGATNMLRIAYIGA 472
Cdd:COG3848  161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGD 210
PLN02765 PLN02765
pyruvate kinase
8-450 1.76e-50

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 179.87  E-value: 1.76e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   8 KILATLGPASGEEAVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVGKFKDGKVDL 87
Cdd:PLN02765  31 KIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  88 VPGQTFTL--DNNEALGDEtrvFLP--HPEILEAVEPGHRLLI--------DDGKLHLVAEACDGKSIRCKVVSGTRIS- 154
Cdd:PLN02765 111 KAGNTVTLtpDQSKEASSE---VLPinFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVKNSATLAg 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 155 -------DRKGVSLPdttlgvgALTEKDRcdldAVLKE-----EIDWVALSFIQRPEDLAEVRKVSRgKVGL-----MSK 217
Cdd:PLN02765 188 slftlhvSQVRIDLP-------TLSEKDK----EVISTwgvpnKIDFLSLSYTRHAEDVREAREFLS-SLGLsqtqiFAK 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 218 IEKPQAVTRLYEIIELSDALMVARGDLGVEVPLENVPGIQKQITRKARRAGKPVVVaTQMLESMITAPVPTRAEVSDVAT 297
Cdd:PLN02765 256 IENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVAN 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 298 AVFEGADAIMLSAESASGQYPVEAVATMNRI---AEQVEREPTYstiidAQRAMP---EPTG-ADAISLAARQIAETLKL 370
Cdd:PLN02765 335 AVLDGADAILLGAETLRGLYPVETISTVGRIcaeAEKVFNQDLY-----FKKTVKyvgEPMShLESIASSAVRAAIKVKA 409
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 371 SAIVTYTASGTTGLRAARERPRTPIIALS-PVVDT------------ARKLSLVWGLHCVVTDDAHDlEDMVNHACEIV- 436
Cdd:PLN02765 410 SVIIVFTSSGRAARLIAKYRPTMPVLSVViPRLKTnqlkwsftgafqARQCLIVRGLFPMLADPRHS-AESTSATNESVl 488
                        490       500
                 ....*....|....*....|.
gi 489054667 437 -FHEEFGKA------GDRVII 450
Cdd:PLN02765 489 kVALDHGKAagviksHDRVVV 509
PRK14725 PRK14725
pyruvate kinase; Provisional
3-334 1.96e-44

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 164.74  E-value: 1.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667   3 RNRKVKILATLGPASGEE-AVIRKLFEAGADVFRINMSHADHDLMRTLVKRIRNVEKELGRPIGILADLQGPKLRVG--- 78
Cdd:PRK14725 137 SGRPTRIMVTLPTEAADDpDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGpia 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  79 ---------------------------------------------------------------------KFKDGKVD--- 86
Cdd:PRK14725 217 pgprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrKLTVTEVDdeg 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  87 ----------LVPGQTFTLDNNEAL----------------GDETRVF--------------LPH-----PEILEAVEPG 121
Cdd:PRK14725 297 vlaegsqtayLANGTLLRLGRHDSTrvgglppveqklrlkvGDRLVLTrddapgdpaqgdapPARisctlPEAFRAARVG 376
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 122 HRLLIDDGKLHLVAEACDGKSIRCKVV----SGTRISDRKGVSLPDTTLGVGALTEKDRCDLDAVLKEeIDWVALSFIQR 197
Cdd:PRK14725 377 ERVWFDDGKIGAVVVKVEADEVELRITharpGGSKLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRS 455
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667 198 PEDLAEV----RKVSRGKVGLMSKIEKPQAVTRLYEIieLSDAL-------MVARGDLGVEVPLENVPGIQKQITRKARR 266
Cdd:PRK14725 456 PEDVRLLldalEKLGADDLGVVLKIETRRAFENLPRI--LLEAMrhprfgvMIARGDLAVEVGFERLAEVQEEILWLCEA 533
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489054667 267 AGKPVVVATQMLESMITAPVPTRAEVSDVATAVfeGADAIMLSaesaSGQYPVEAVATMNRIAEQVER 334
Cdd:PRK14725 534 AHVPVIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDILRRMEE 595
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
355-467 1.61e-42

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 146.47  E-value: 1.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489054667  355 DAISLAARQIAETLKLSAIVTYTASGTTGLRAARERPRTPIIALSPVVDTARKLSLVWGLHCVVTDDAHDLEDMVNHACE 434
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 489054667  435 IVFHEEFGKAGDRVIITAGVPFGTPGATNMLRI 467
Cdd:pfam02887  81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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