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Conserved domains on  [gi|489055176|ref|WP_002965336|]
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MULTISPECIES: Bax inhibitor-1/YccA family protein [Brucella]

Protein Classification

Bax inhibitor-1/YccA family protein( domain architecture ID 10179639)

Bax inhibitor-1/YccA family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded by in an FtsH-dependent manner

Gene Ontology:  GO:0016020
PubMed:  18336295|18440869
TCDB:  1.A.14.2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 26-242 6.45e-76

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


:

Pssm-ID: 198414  Cd Length: 211  Bit Score: 228.60  E-value: 6.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  26 GLRSYMLGVYNMMAIGLAVTGLAAFGTAVLAQSNpafqqLLFASPLRWVIMLAPLAAVFFLSFRIQSLSVGTAQAIFWGY 105
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPALL-----LIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 106 AALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISV 185
Cdd:cd10432   76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489055176 186 IGVLIFAGLTAYDTQEIKEMYYEGDAADTQgRKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEAGGGESGY-KDAIMGALSLYLDFINLFLFLLRLFG 211
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 26-242 6.45e-76

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 228.60  E-value: 6.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  26 GLRSYMLGVYNMMAIGLAVTGLAAFGTAVLAQSNpafqqLLFASPLRWVIMLAPLAAVFFLSFRIQSLSVGTAQAIFWGY 105
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPALL-----LIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 106 AALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISV 185
Cdd:cd10432   76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489055176 186 IGVLIFAGLTAYDTQEIKEMYYEGDAADTQgRKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEAGGGESGY-KDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 16-245 8.89e-76

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 228.91  E-value: 8.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  16 GARADAGIDQGLRSYMLGVYNMMAIGLAVTGLAAFgtavLAQSNPAFQQLLFASP-LRWVIMLAPLAAVFFLSFRIQSLS 94
Cdd:COG0670    8 AGAAAAASDAGLRKVLRNTYGLLALGLLLTALVAY----LGMALPGLAALLFGSPgLFWVLLIAPLGLVFLLSKLANRAN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  95 VGTAQAIFWGYAALVGLSLSSIFIVFTG----QSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVV 170
Cdd:COG0670   84 SAAALALLFAYTALMGLTLSPILLVYTGlsgpASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLV 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055176 171 NIFLGSTALQFAISVIGVLIFAGLTAYDTQEIKEMYYEGDAAdtqgrkiVMGALRLYLDFINMFMFLLQFMGNRE 245
Cdd:COG0670  164 NIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYETNKQY-------IMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 28-241 2.88e-53

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 170.82  E-value: 2.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176   28 RSYMLGVYNMMAIGLAVTGLAAFGTAvlaqSNPAFQQLLFASPLRWVIMLAPLAAVF--FLSFRIQSLSVGTAQAIFWGY 105
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVL----SSPALLFPSLHPPLFWVLIIAPLGLLFgaLLLARKRKYSSNVALLLLLAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  106 AALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISV 185
Cdd:pfam01027  77 TLLMGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489055176  186 IGVLIFAGLTAYDTQEIKEMYYEGDAADTqgrkiVMGALRLYLDFINMFMFLLQFM 241
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEYGDYDA-----ILAALSLYLDFINLFLSLLRIL 207
PRK10447 PRK10447
FtsH protease modulator YccA;
35-242 6.93e-08

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 51.38  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  35 YNMMAIGLAVTGLAAFGTAVLAQSNPAFqqllfasplrwVIMLAPLAAVFFLSFRIQSLSVGTAQAI----FWGYAalVG 110
Cdd:PRK10447  25 YFLLSLTLAFSAITATASTVLMLPSPGL-----------ILTLVGMYGLMFLTYKTANKPTGILSAFaftgFLGYI--LG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 111 LSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISVIGVLI 190
Cdd:PRK10447  92 PILNTYLSAGMGDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILI 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489055176 191 FAGLTAYDTQEIkemYYEGDAadtqgrKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:PRK10447 172 SSGAILFETSNI---IHGGET------NYIRATVSLYVSLYNIFVSLLSILG 214
 
Name Accession Description Interval E-value
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 26-242 6.45e-76

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 228.60  E-value: 6.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  26 GLRSYMLGVYNMMAIGLAVTGLAAFGTAVLAQSNpafqqLLFASPLRWVIMLAPLAAVFFLSFRIQSLSVGTAQAIFWGY 105
Cdd:cd10432    1 GLRSFMKKVYGLMAAGLLLTAVGAYVGASTPALL-----LIAGSPLMWVLLIAELALVFGLSFRINKMSVATALPLFFAF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 106 AALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISV 185
Cdd:cd10432   76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489055176 186 IGVLIFAGLTAYDTQEIKEMYYEGDAADTQgRKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYEAGGGESGY-KDAIMGALSLYLDFINLFLFLLRLFG 211
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 16-245 8.89e-76

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 228.91  E-value: 8.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  16 GARADAGIDQGLRSYMLGVYNMMAIGLAVTGLAAFgtavLAQSNPAFQQLLFASP-LRWVIMLAPLAAVFFLSFRIQSLS 94
Cdd:COG0670    8 AGAAAAASDAGLRKVLRNTYGLLALGLLLTALVAY----LGMALPGLAALLFGSPgLFWVLLIAPLGLVFLLSKLANRAN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  95 VGTAQAIFWGYAALVGLSLSSIFIVFTG----QSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVV 170
Cdd:COG0670   84 SAAALALLFAYTALMGLTLSPILLVYTGlsgpASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLV 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055176 171 NIFLGSTALQFAISVIGVLIFAGLTAYDTQEIKEMYYEGDAAdtqgrkiVMGALRLYLDFINMFMFLLQFMGNRE 245
Cdd:COG0670  164 NIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYETNKQY-------IMAALSLYLDFINLFLSLLRLLGGRR 231
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 28-241 2.88e-53

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 170.82  E-value: 2.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176   28 RSYMLGVYNMMAIGLAVTGLAAFGTAvlaqSNPAFQQLLFASPLRWVIMLAPLAAVF--FLSFRIQSLSVGTAQAIFWGY 105
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVL----SSPALLFPSLHPPLFWVLIIAPLGLLFgaLLLARKRKYSSNVALLLLLAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  106 AALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISV 185
Cdd:pfam01027  77 TLLMGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489055176  186 IGVLIFAGLTAYDTQEIKEMYYEGDAADTqgrkiVMGALRLYLDFINMFMFLLQFM 241
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYGEYGDYDA-----ILAALSLYLDFINLFLSLLRIL 207
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 34-245 4.13e-18

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 80.34  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  34 VYNMMAIGLAVTglaaFGTAVLAQSNPAFQQLLFASP-LRWVIMLAPLAAVFFLSFRIQSlsVGTAQAIFWGYAALVGLS 112
Cdd:cd10429   34 VYSILSVQLLAT----TAVSALFYLSPSIKTFVQSHPwLFLISLIGSLILLIALYWKRHS--HPVNLILLSLFTLCEAYT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 113 LSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLG-STALQFAISVIGVLIF 191
Cdd:cd10429  108 VGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFFPySPTFELVYAGLGALLF 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489055176 192 AGLTAYDTQEIKEMYYEGDAadtqgrkiVMGALRLYLDFINMFMFLLQFMGNRE 245
Cdd:cd10429  188 SGYIVYDTQLIMKRLSPDEY--------ILAAISLYLDIINLFLSILRILAAMN 233
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 122-242 1.42e-15

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 72.62  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 122 GQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISVIGVLIFAGLTAYDTQE 201
Cdd:cd10433   90 GQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSR 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489055176 202 IkemyyegdaADTQGRKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd10433  170 I---------IHGGETNYIMATVSLYVSIYNLFVSLLNLLG 201
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 23-245 1.55e-13

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 67.25  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  23 IDQGLRSYMLGVYNMMAIGLAVTGLAAFgtavlaqsnpAFQQLLFASPLRWVIMLapLAAVFFLSFRIQSLSVGTAQAIF 102
Cdd:cd10430    4 ISPSVQQHLKKVYLTLAVALLAAAVGAY----------VHMVINIGGLLTGLLSL--GLSLWLAFTPSTGKNEPKRLGLL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 103 WGYAALVGLSLSSI--FIVFTGQSIVRTFFV-TAASFGALSLYG-YTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTA 178
Cdd:cd10430   72 LGFAFLTGASLGPLldLVIAINPSIIVTAFLgTAVIFACFSLAAlLAKRREYLYLGGLLSSALSILLLVSLANIFGGSKF 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055176 179 LQFAISVIGVLIFAGLTAYDTQEIKEMYYEGDaadtqgRKIVMGALRLYLDFINMFMFLLQFMGNRE 245
Cdd:cd10430  152 LFQAELYLGLLVFCGFVLFDTQMIIEKAENGD------RDYIWHALDLFVDFVALFRRLLIILAKKE 212
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 104-242 1.09e-11

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 62.04  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 104 GYAALVGLSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAI 183
Cdd:cd06181   70 GFTGLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVA 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489055176 184 SVIGVLIFAGLTAYDTQEIKEMYYEGDaadtqgRKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd06181  150 AAVGLVLFCGFLLYDTQLIIHKAEVGP------EDYINACISLYLDIINIFIRLLTILA 202
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 14-243 1.97e-10

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 59.32  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  14 VGGARADAGIDQGLRSYMLGVYNMMAIGLAVTGLAAFGTAvlaqSNPAFQQLLFASPlrWVIMLAPLAAVFFLSFRIQSL 93
Cdd:cd10431   27 IGAIEKAVIWPQYVRDRIHSTYMYFGGSLGLTALAAVALS----RSPALMRLMAAGP--WLAIGATLAAMIGSGMLVRSY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  94 ----SVGTAQAIFWGYAALVGLSLSSIFIVfTGQSIVRTFFVTAASFGALSLYGYTTKRN-LSAMGSFLMMGLFGLILAS 168
Cdd:cd10431  101 typeNPGAKHLAWLGHSGVQGAVLAPLCFL-GGPLLIRAALYTAGIVGGLSTVAACAPSEkFLYMGGPLAIGLGVVFASS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 169 VVNIFLGST----ALQFAISVIGVL-IFAGLTAYDTQEIKEMYYEGDAADTQGRKIVMGALRLYLDFINMFMFLLQFMGN 243
Cdd:cd10431  180 LGSMFLPPTtalgAGLYSVSLYGGLvLFGGFLLYDTQKIIKRAETHPLYGVRKYDPINASMSIYMDTINIFIRLVTILAG 259
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 131-242 5.15e-09

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 54.85  E-value: 5.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 131 VTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISVIGVLIFAGLTAYDTQEI-KEMYYEG 209
Cdd:cd10428  110 ITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYASLGALLFSLYLAVDTQLLmGGRKYEL 189

                         90       100       110
                 ....*....|....*....|....*....|...
gi 489055176 210 DAADtqgrkIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:cd10428  190 SPEE-----YIFAALNIYVDIVNIFLYILQLIG 217
PRK10447 PRK10447
FtsH protease modulator YccA;
35-242 6.93e-08

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 51.38  E-value: 6.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176  35 YNMMAIGLAVTGLAAFGTAVLAQSNPAFqqllfasplrwVIMLAPLAAVFFLSFRIQSLSVGTAQAI----FWGYAalVG 110
Cdd:PRK10447  25 YFLLSLTLAFSAITATASTVLMLPSPGL-----------ILTLVGMYGLMFLTYKTANKPTGILSAFaftgFLGYI--LG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055176 111 LSLSSIFIVFTGQSIVRTFFVTAASFGALSLYGYTTKRNLSAMGSFLMMGLFGLILASVVNIFLGSTALQFAISVIGVLI 190
Cdd:PRK10447  92 PILNTYLSAGMGDVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILI 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489055176 191 FAGLTAYDTQEIkemYYEGDAadtqgrKIVMGALRLYLDFINMFMFLLQFMG 242
Cdd:PRK10447 172 SSGAILFETSNI---IHGGET------NYIRATVSLYVSLYNIFVSLLSILG 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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