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Conserved domains on  [gi|489055375|ref|WP_002965532|]
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MULTISPECIES: low molecular weight phosphatase family protein [Brucella]

Protein Classification

low molecular weight phosphatase family protein( domain architecture ID 10001303)

low molecular weight phosphatase (LMWP) family protein similar to arsenate reductase ArsC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
20-154 1.39e-35

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


:

Pssm-ID: 440163  Cd Length: 137  Bit Score: 120.27  E-value: 1.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  20 PTSILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGER-DPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTL 98
Cdd:COG0394    3 PKRVLFVCTGNICRSPMAEALLRHLAGGRVEVDSAGTEPGGPvDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLVITM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489055375  99 TPLAHHTVLERMRGFSVDVEYWPTPDPTlvTGSREqimaAYRDVRDRLKRRITLRF 154
Cdd:COG0394   83 CDSAAEELCPLFPGAAKLLLHWDVPDPY--YGGLE----AFREVRDEIERRIEALL 132
 
Name Accession Description Interval E-value
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
20-154 1.39e-35

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 120.27  E-value: 1.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  20 PTSILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGER-DPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTL 98
Cdd:COG0394    3 PKRVLFVCTGNICRSPMAEALLRHLAGGRVEVDSAGTEPGGPvDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLVITM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489055375  99 TPLAHHTVLERMRGFSVDVEYWPTPDPTlvTGSREqimaAYRDVRDRLKRRITLRF 154
Cdd:COG0394   83 CDSAAEELCPLFPGAAKLLLHWDVPDPY--YGGLE----AFREVRDEIERRIEALL 132
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 23-155 2.11e-31

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 109.46  E-value: 2.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGERDPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTLTPLA 102
Cdd:cd16345    2 VLFLCTGNSARSQMAEALLRHLGGDRFEAYSAGSEPAGVNPLAIEVMKEIGIDISGQRSKSLDEFLGQEFDYVITVCDNA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489055375 103 HhtvlER--MRGFSVDVEYWPTPDPTLVTGSREQIMAAYRDVRDRLKRRITLRFG 155
Cdd:cd16345   82 A----EVcpVFPGAVKRLHWGFPDPAAAEGSEEEKLEAFRRVRDEIKERIEALLA 132
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
23-149 1.40e-13

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 63.93  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375   23 ILFVCGKNAIRSPMAELLARTLLP-----ANIYIASAGVKR--GER-DPFVDAVLSEEGLSLDNRQPRGI--EELADgyF 92
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEkaglgDKVEVDSAGTGAwpGNPaDPRAVEVLKEHGIDLSGHYARQLstEDFAS--F 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055375   93 DLIVTLT--------PLAHHTVLERMRGFSVDVEYWPTPDPtlvtgSREQImAAYRDVRDRLKRR 149
Cdd:pfam01451  79 DLILAMDsehkrdlcPLAPERYRAKVMLLGEYGEQLDIPDP-----YYGSI-DAFEEVRDLIERR 137
LMWPc smart00226
Low molecular weight phosphatase family;
23-151 4.71e-13

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 62.10  E-value: 4.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375    23 ILFVCGKNAIRSPMAELLARTLLPANIYIASAGVK--RGER-DPFVDAVLSEEGLSLDNrQPRGIEELADGYFDLIVTLT 99
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDRVKIDSAGTGawVGGGaDPRAVKVLKEHGIDLSH-HASQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 489055375   100 PlAHHTVLERMRGFSVDV-----EYWPTPDPtlVTGSReqimAAYRDVRDRLKRRIT 151
Cdd:smart00226  80 G-SHLRNICRLKPPSRAKvelfgHYVDVDDP--YYGGI----DGFERVYDELENALQ 129
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
23-139 2.34e-08

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 49.91  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLPaNIYIASAG----VKRGErDPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTL 98
Cdd:PRK10126   5 ILVVCVGNICRSPTAERLLQRYHP-ELKVESAGlgalVGKGA-DPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489055375  99 TPLAHHTVLE---RMRGFSVDVEYWPT----PDPtlVTGSREQIMAAY 139
Cdd:PRK10126  83 EKRHIERLCEmapEMRGKVMLFGHWDNeceiPDP--YRKSREAFEAVY 128
 
Name Accession Description Interval E-value
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
20-154 1.39e-35

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 120.27  E-value: 1.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  20 PTSILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGER-DPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTL 98
Cdd:COG0394    3 PKRVLFVCTGNICRSPMAEALLRHLAGGRVEVDSAGTEPGGPvDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLVITM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489055375  99 TPLAHHTVLERMRGFSVDVEYWPTPDPTlvTGSREqimaAYRDVRDRLKRRITLRF 154
Cdd:COG0394   83 CDSAAEELCPLFPGAAKLLLHWDVPDPY--YGGLE----AFREVRDEIERRIEALL 132
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 23-155 2.11e-31

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 109.46  E-value: 2.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGERDPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTLTPLA 102
Cdd:cd16345    2 VLFLCTGNSARSQMAEALLRHLGGDRFEAYSAGSEPAGVNPLAIEVMKEIGIDISGQRSKSLDEFLGQEFDYVITVCDNA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489055375 103 HhtvlER--MRGFSVDVEYWPTPDPTLVTGSREQIMAAYRDVRDRLKRRITLRFG 155
Cdd:cd16345   82 A----EVcpVFPGAVKRLHWGFPDPAAAEGSEEEKLEAFRRVRDEIKERIEALLA 132
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
23-149 1.40e-13

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 63.93  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375   23 ILFVCGKNAIRSPMAELLARTLLP-----ANIYIASAGVKR--GER-DPFVDAVLSEEGLSLDNRQPRGI--EELADgyF 92
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEkaglgDKVEVDSAGTGAwpGNPaDPRAVEVLKEHGIDLSGHYARQLstEDFAS--F 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055375   93 DLIVTLT--------PLAHHTVLERMRGFSVDVEYWPTPDPtlvtgSREQImAAYRDVRDRLKRR 149
Cdd:pfam01451  79 DLILAMDsehkrdlcPLAPERYRAKVMLLGEYGEQLDIPDP-----YYGSI-DAFEEVRDLIERR 137
LMWPc smart00226
Low molecular weight phosphatase family;
23-151 4.71e-13

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 62.10  E-value: 4.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375    23 ILFVCGKNAIRSPMAELLARTLLPANIYIASAGVK--RGER-DPFVDAVLSEEGLSLDNrQPRGIEELADGYFDLIVTLT 99
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGDRVKIDSAGTGawVGGGaDPRAVKVLKEHGIDLSH-HASQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 489055375   100 PlAHHTVLERMRGFSVDV-----EYWPTPDPtlVTGSReqimAAYRDVRDRLKRRIT 151
Cdd:smart00226  80 G-SHLRNICRLKPPSRAKvelfgHYVDVDDP--YYGGI----DGFERVYDELENALQ 129
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 23-152 8.96e-13

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 61.68  E-value: 8.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLP-ANIYIASAGVKRGERDPFVD---AVLSEEGLSLDNRQPRGI-EELADGYfDLIVT 97
Cdd:cd16344    3 ILFVCTGNTCRSPMAEAILKKLLEeLDVEVKSAGIFAVDGSPASPnavEVLKEKGIDLSGHRSQQLtEELLEWA-DLILT 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055375  98 LTPlAHHTVLERMRGFSVD-----VEYwptpdptlVTGSREQI-------MAAYRDVRDRLKRRITL 152
Cdd:cd16344   82 MTE-SHKQALLSLYPEAADkvftlKEY--------VGGEDGDIsdpfggsLEVYRQTAEELEELIEK 139
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 22-150 3.61e-12

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 59.81  E-value: 3.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  22 SILFVCGKNAIRSPMAELLARTLLPANIYIASAGV---KRGERDPFVDAVLSEEGLSLDNRQPRGIEELADGYfDLIVTL 98
Cdd:cd00115    1 SILFICTGNICRSPMAEAIFKQLLGDEWKVDSAGTgahHGEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNY-DLVLVM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489055375  99 TPLAHHTVLERM---RGFS----VDVEYWPTPDPtlvtgSREQImAAYRDVRDRLKRRI 150
Cdd:cd00115   80 DGSNLDKIPRIFpeaRGKTwlphVKLEHGEIDDP-----YRGDI-EDFRRVRDELENAS 132
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 22-110 1.84e-09

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 52.83  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  22 SILFVC-GkNAIRSPMAELLARTLLPA----NIYIASAGVKR---GER-DPFVDAVLSEEGLSLDNRQPRGIEELADGYF 92
Cdd:cd16343    2 KILFVClG-NICRSPMAEAVLRHLLPKaggdDVEVDSAGTSAwhgGEPpDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                         90
                 ....*....|....*...
gi 489055375  93 DLIVTLTPlAHHTVLERM 110
Cdd:cd16343   81 DLILAMDE-SNLRDLRRL 97
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
23-139 2.34e-08

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 49.91  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLPaNIYIASAG----VKRGErDPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTL 98
Cdd:PRK10126   5 ILVVCVGNICRSPTAERLLQRYHP-ELKVESAGlgalVGKGA-DPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489055375  99 TPLAHHTVLE---RMRGFSVDVEYWPT----PDPtlVTGSREQIMAAY 139
Cdd:PRK10126  83 EKRHIERLCEmapEMRGKVMLFGHWDNeceiPDP--YRKSREAFEAVY 128
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 22-148 7.58e-08

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 48.86  E-value: 7.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  22 SILFVCGKNAIRSPMAELLARTLLPAnIYIASAGVK---RGERDPFVDAVLSEEGLSLDNRQPRGIE-ELADGYfDLIVT 97
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLRKRLPG-VKVKSAGVHglvKHPADATAADVAANHGVSLEGHAGRKLTaEMARNY-DLILA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489055375  98 LTP--LAHHT-VLERMRGFSVDVEYW----PTPDPtlVTGSREqimaAYRDVRDRLKR 148
Cdd:PRK11391  82 MESehIAQVTaIAPEVRGKTMLFGQWleqkEIPDP--YRKSQD----AFEHVYGMLER 133
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
23-63 1.71e-03

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 35.97  E-value: 1.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLlpANIYIASAGVKRGERDP 63
Cdd:COG4551    4 VLFVCSRNRWRSPTAEQVFRNH--PGVEVRSAGTSPDARVP 42
PRK13530 PRK13530
arsenate reductase (thioredoxin);
23-150 2.66e-03

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 35.88  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055375  23 ILFVCGKNAIRSPMAELLARTLLPANIYIASAGVKRGERDPFVDAVLSEEGLSLDNRQPRGIEELADGYFDLIVTLTplA 102
Cdd:PRK13530   6 IYFLCTGNSCRSQMAEGWGKQYLGDKWNVYSAGIEAHGVNPNAIKAMKEVGIDISNQTSDIIDNDILNNADLVVTLC--S 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489055375 103 HHTVLERMRGFSVDVEYWPTPDPTlvtgsrEQIMAAYRDVRDRLKRRI 150
Cdd:PRK13530  84 HADDVCPSTPPHVKRVHWGFDDPA------GKEWSEFQRVRDEIGERI 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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