|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-435 |
3.62e-62 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 209.10 E-value: 3.62e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 22 LGIFGLVWAADAMQ--VLAVGFTGAAIAKTFGLTVPQALQ---TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDA 96
Cdd:TIGR00898 89 LSDLGLAATEPCLDgwEYSYDTFSSTIVTEWDLVCEDAWKvdlTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 97 LFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSvagvedAW 176
Cdd:TIGR00898 169 VSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIP------DW 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 177 RYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKPeLPPGAKLLAPRLVTNER---------LL 247
Cdd:TIGR00898 243 RWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-LPAEVLSLSLEKDLSSSkkqysfldlFR 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 248 SPNLRQRTLTSLAIWFLVSVSYYGIFtwipakLASDGFGFvRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFV 327
Cdd:TIGR00898 322 TPNLRKTTLCLMMLWFTTAFSYYGLV------LDLGNLGG-NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLL 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 328 SAAACAL--------FTVATSSSVVGASILIMSFAllgtwgALYAFTPELYPTALRASGMGAAGAMARLGGLLAP-SAMA 398
Cdd:TIGR00898 395 AGVALLLllfvpvdlYFLRTALAVLGKFGITSAFQ------MVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPfLVYL 468
|
410 420 430
....*....|....*....|....*....|....*..
gi 489055956 399 VVINQSFYTAVamFAGLLALAGIIAFFInVETRQQAL 435
Cdd:TIGR00898 469 GEKWLFLPLVL--FGGLALLAGILTLFL-PETKGVPL 502
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-425 |
1.83e-57 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 192.82 E-value: 1.83e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 22 LGIFGLVWAADAMQVLAVGFTGAAIAKTF--GLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFG 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 100 LLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWA-TSVAGVEDAWRY 178
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLlIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 179 IFIVTAAPALIGIWlrfrvpespmhllksgrveeakavinlvlsrngkpelppgakllaprlvtnerllspnLRQRTLTS 258
Cdd:cd17316 161 LFLIGALPALLALL----------------------------------------------------------LRRRTLLL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 259 LAIWFLVSVSYYGIFTWIPAKLASD-GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTV 337
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 338 A--TSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAM-FAG 414
Cdd:cd17316 263 LlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAlILA 342
|
410
....*....|.
gi 489055956 415 LLALAGIIAFF 425
Cdd:cd17316 343 LLAIVALIVAL 353
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
22-426 |
1.70e-47 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 166.94 E-value: 1.70e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 22 LGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLL 101
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 102 SAFAPDFGSLLALRFLTGLAVGGTlPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWatsVAGVEDAWRYIFI 181
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAW---LVMPRLGWRWLLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 182 VTAAPALIGIWLRFRVPespmhllksgrveeakavinlvlsrngkpelppgakllaprlvtnerllspnlrQRTLTSLAI 261
Cdd:cd17372 157 FSSVPSSLLLVFYRWTP------------------------------------------------------KTTLLLWVI 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 262 WFLVSVSYYGIFTWIPAKLASDGFGFVRG--------------------YGFLVVVALAQLPGYALAAYGVEAWGRRKTL 321
Cdd:cd17372 183 WFGNAFAYYGVVLLTTELNNSHNVCGSKSdsdsgesptekqcrnsndvdYRDVFIATFAEFPGLLISAAMIDRLGRKASM 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 322 IGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVI 401
Cdd:cd17372 263 ASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLV 342
|
410 420
....*....|....*....|....*
gi 489055956 402 NQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17372 343 HGSQTIALLLFSVVCLVSAICVCLL 367
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-430 |
7.19e-46 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 163.24 E-value: 7.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 29 WAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDF 108
Cdd:cd17371 8 WALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 109 GSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVG-TVVIAIAAWATSVAGVEDAWRYIFIVTAAPA 187
Cdd:cd17371 88 WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwLLATLLAALLFPLLPPEIAWRVLFLLGALPA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 188 LIGIWLRFRVPESPMHLLKsgrveeakavinlvlsRNGKPELPPGAKLLAprlvtnerLLSPNLRQRTLTSLAIWFLVSV 267
Cdd:cd17371 168 LLVLFIRRFVKEPPQWQAA----------------RAARRHFADRPSLRE--------LFSPPLLRTTLLASLLATGALG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 268 SYYGIFTWIPAKLASD-GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSS-SVVG 345
Cdd:cd17371 224 GYYGITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSpTLIL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 346 ASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQ-SFYTAVAMFAGLLALAGIIAF 424
Cdd:cd17371 304 ILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSgSLGTAIAVFAAVYYIAGLVLA 383
|
....*.
gi 489055956 425 FINVET 430
Cdd:cd17371 384 LLLPET 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
5-401 |
1.36e-41 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 151.74 E-value: 1.36e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 5 IEETLDQAGTGSFQRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGR 84
Cdd:TIGR00895 2 VQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 85 RRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIA-IA 163
Cdd:TIGR00895 82 RRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGfLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 164 AWATSVAGvedaWRYIFIV-TAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAV--INLVLSRNGKPELPPGAKLLAPRL 240
Cdd:TIGR00895 162 GWLIPVFG----WRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVnaIAPQMQAEAQSALPEQKSTQGTKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 241 VTNERLLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKT 320
Cdd:TIGR00895 238 SVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 321 LIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVV 400
Cdd:TIGR00895 318 ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
.
gi 489055956 401 I 401
Cdd:TIGR00895 398 L 398
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
6-435 |
5.60e-41 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 155.13 E-value: 5.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 6 EETLDQAGTGSFQRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRR 85
Cdd:TIGR01299 153 ELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRK 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 86 RILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAW 165
Cdd:TIGR01299 233 QCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAW 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 166 A----------TSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRN----GKPE-LP 230
Cdd:TIGR01299 313 AiiphygwsfqMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNmrakGHPEkVF 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 231 PGAKLLAPRLV------------------------------TNERLLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIP--- 277
Cdd:TIGR01299 393 SVNHIKTIHQEdelieiesdtgtwyqrcfvralsegggiwgNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPdmi 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 278 ----------------------------------------------AKLASDGF-----------------GFVRGYGFL 294
Cdd:TIGR01299 473 khlqaddyaaltknfpgdkvahfsfnftlenqihrggeydndkfigLKFKSVSFedslfeectfddvtssnTFFKNCTFI 552
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 295 VVV-------------------------------------------------ALAQLPGYALAAYGVEAWGRRKTLIGFL 325
Cdd:TIGR01299 553 DTLfentdfeeykfidsefqncsflhnkegcpidfdgddegaymiyfvnflgTLAVLPGNIVSALLMDKIGRLRMLAGSM 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 326 FVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSF 405
Cdd:TIGR01299 633 VLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITK 712
|
570 580 590
....*....|....*....|....*....|
gi 489055956 406 YTAVAMFAGLLALAGIIAFFINvETRQQAL 435
Cdd:TIGR01299 713 AAPILFASAALACGGLLALKLP-DTRGQVL 741
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
24-424 |
1.68e-40 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 150.57 E-value: 1.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:cd17439 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWA----------TSVAGVE 173
Cdd:cd17439 83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAiiphygwsfqMGSAYQF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 174 DAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKPELPPgakllaprlvtnERLLSPNL-- 251
Cdd:cd17439 163 HSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHP------------ERVFSVTHik 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 252 RQRTLTSLAIWFLVSVSYYGIFTWIP------------------------------------------------------ 277
Cdd:cd17439 231 RRITLMMMAVWFTMSFSYYGLTVWFPdmikhlqksvvfedslfeecyfeditssntffknctfistlfyntdlfeykfin 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 278 AKLASDGFGFVRG---------------YGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSS 342
Cdd:cd17439 311 SKLINSTFLHNKEgclldfsdennaymiYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSES 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 343 VVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGII 422
Cdd:cd17439 391 AMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAVPILLASAALAAGSSL 470
|
..
gi 489055956 423 AF 424
Cdd:cd17439 471 AL 472
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
60-418 |
1.86e-40 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 146.96 E-value: 1.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:cd17317 30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 140 KNRGRWLVMLEGFWAVGTVVIAIAAWATSvagvedAWRYIFIVTAAPALIGIWLRFRVPespmhllksgrveeakavinl 219
Cdd:cd17317 110 KYRSFVGILFGLFWALGYMLLALLAYLIR------DWRWLQLAISLPGLLFLLLLWWLP--------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 vlsrngkpelppgakllaprlvtnerllspnlrQRTLTSLAIWFLVSVSYYGIftwipaKLASDGFGfvrGYGFL--VVV 297
Cdd:cd17317 163 ---------------------------------RRTIIVGLIWFVTSLVYYGL------SLNSSNLG---GNLYLnfFLS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 298 ALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACaLFTVATSssvVGASILIMSFALLG------TWGALYAFTPELYP 371
Cdd:cd17317 201 GLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLAC-LVTALLP---DDENTLALTLALVGkfaisaAFSVIYLYTAELYP 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489055956 372 TALRASGMGAAGAMARLGGLLAP-----SAMAVVINQSFYTAVAMFAGLLAL 418
Cdd:cd17317 277 TVVRNTGVGLCSTVARVGAILAPfivllGKIGPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
26-426 |
6.42e-40 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 146.88 E-value: 6.42e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 26 GLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFA 105
Cdd:cd17441 5 GLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 106 PDFGSLLALRFLTGLAVGGtLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGT---VVIAIAAWATSvagvedAWRYIFIV 182
Cdd:cd17441 85 PIYSWILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTvfeVLLAVFVMPTL------GWRWLLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 183 TAAPALIGIWLRFRVPESPMHLlksgrveeakavinlvlsrngkpelppgakllaprlvtnerllspnlrqRTLTSLAIW 262
Cdd:cd17441 158 SALPLLIFAVLCFWLPESARYW-------------------------------------------------TTILLWFIW 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 263 FLVSVSYYGIFTWIPAKLASDG------FGFVRG-------------YGFLVVVALAQLPGYALAAYGVEAWGRRKTLIG 323
Cdd:cd17441 189 FSNAFSYYGLVLLTTELFQAGDvcsgssGKKVEGkcsleceylttsdYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMAL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 324 FLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQ 403
Cdd:cd17441 269 CFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLES 348
|
410 420
....*....|....*....|...
gi 489055956 404 SFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17441 349 SVYLTLSVYSGCCLLAAIASCFL 371
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
24-431 |
1.60e-38 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 145.07 E-value: 1.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:cd17438 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAW----------ATSVAGVE 173
Cdd:cd17438 83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWsiiphygwgfSMGTNYHF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 174 DAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKPELPPGAKLlaprLVTNERllspnlRQ 253
Cdd:cd17438 163 HSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGTPEKVF----TVSNIK------RK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 254 RTLTSLAIWFLVSVSYYGIFTWIP------------------------------------------------------AK 279
Cdd:cd17438 233 NTLFLAVVWFTMAFSYYGLTVWFPdmirylqkhvtfedslfdecyfedvtstdtyfknctiestifyntdlyehkfidCR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 280 LASDGF---------GFVRGYGFLVVV-----ALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAAC-ALFTVATSSSVV 344
Cdd:cd17438 313 FINSTFleqkegchmDFEEDNDFLIYLvsflgSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCfFLFFGNSESAMI 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 345 GASILIMSfALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAF 424
Cdd:cd17438 393 GWQCLFCG-TSIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNSIFASFVGITKVIPILLASTALVGGGLISL 471
|
....*..
gi 489055956 425 FINvETR 431
Cdd:cd17438 472 RLP-ETR 477
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
24-424 |
1.76e-38 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 144.94 E-value: 1.76e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:cd17363 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWA----------TSVAGVE 173
Cdd:cd17363 83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAiiphygwgfsMGTAYQF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 174 DAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKPELPPgakllaprlvtnERLLSPN--L 251
Cdd:cd17363 163 HSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAKGHP------------ERVFTVShiK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 252 RQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGF-----------------GFVRGYGFLVVV----------------- 297
Cdd:cd17363 231 RMNTLFLAIVWFTMSFSYYGLTVWFPDMIKYLQFedslfeecyfedvtstnTFFENCTFINTVfyntdlfeykfidsrfl 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 298 -------------------------------ALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGA 346
Cdd:cd17363 311 nstfflkekcgchlnddeenayliylvsflgSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIG 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489055956 347 SILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAF 424
Cdd:cd17363 391 LQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGITKVIPILLASAALVCGGLLAL 468
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-432 |
6.83e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 135.38 E-value: 6.83e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 11 QAGTGSFQRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLI 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 91 TVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIA-IAAWATSV 169
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPpLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 170 AGvedaWRYIFIVTAAPALIGIWLRFrvpespmhllksgrveeakavinlvlsrngkpelppgakllaprlvtnerllsp 249
Cdd:COG2271 161 FG----WRAAFLILGLPGLLLALLRF------------------------------------------------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 250 nlrqrtLTSLAIWFLVSVSYYGIFTWIPAKLASD-GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRK--TLIGFLF 326
Cdd:COG2271 183 ------WLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 327 VSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFY 406
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
410 420
....*....|....*....|....*..
gi 489055956 407 TAV-AMFAGLLALAGIIAFFINVETRQ 432
Cdd:COG2271 337 QAAfLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-426 |
1.09e-34 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 131.94 E-value: 1.09e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 22 LGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 102 SAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWL-VMLEGFWAVGTVVIAIAAWATSVAGvedaWRYIF 180
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVtLMFCGYPLGAALGGFLAAALIPAFG----WRSVF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 181 IVTAAPALIgiwlrfrvpespmhllksgrveeakavinlvlsrngkpelppgaklLAPRLVTnerllspnlrqrTLTSLA 260
Cdd:cd17365 157 LLGGVPPLI----------------------------------------------LLPLLRG------------TLLLWV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 261 IWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATS 340
Cdd:cd17365 179 TFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 341 SSVV-GASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSF-YTAVAMFAGLLAL 418
Cdd:cd17365 259 SLVLlYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLgPESVFLALAIPAA 338
|
....*...
gi 489055956 419 AGIIAFFI 426
Cdd:cd17365 339 LGALAVLL 346
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
63-430 |
1.44e-32 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 128.16 E-value: 1.44e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLAL---RFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:pfam00083 54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 140 KNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAvinl 219
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEARE---- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 VLSRNGKPELPPG----------AKLLAPRLVTNERLLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLaSDGFGFVR 289
Cdd:pfam00083 210 VLAKLRGVPDVDReldeikdsleAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTI-FENLGLSD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 290 GYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVAT---SSSVVGASILIMSFALLgtWGALYAFT 366
Cdd:pfam00083 289 SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVAllgVSKSDWAGIVAIVFIAL--FIAFFAMG 366
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055956 367 P---------ELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQS--FYTAvAMFAGLLALAGIIAFFINVET 430
Cdd:pfam00083 367 WgpvpwvivsELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIglGYTF-FIFAGLLVLFIIFVFFFVPET 440
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
24-392 |
2.39e-31 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 125.03 E-value: 2.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:cd17440 3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWA--------TSVAGVED- 174
Cdd:cd17440 83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAiiphygwsFSMGSAYQf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 175 -AWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRN----GKPElppgakllapRLVTNERLLSP 249
Cdd:cd17440 163 hSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNmrarGQPE----------KVFTVNRIKKD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 250 NlrqrTLTSLAIWFLVSVSYYGIFTWIPAKLASDGF----------------------GFVRGYGFLVVV---------- 297
Cdd:cd17440 233 N----TIKLTIVWLTLSFGYYGLSVWFPDVIKHLQFksvtfedslfkscffedvtsvnTYFRNCTFIETVfyntdledyk 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 298 --------------------------------------ALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVAT 339
Cdd:cd17440 309 fidsdfinctffhnktgcqitfdddysaywiyfvnflgTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGT 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 489055956 340 SSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLL 392
Cdd:cd17440 389 SESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVL 441
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
38-424 |
8.07e-30 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 119.68 E-value: 8.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 38 AVGFTGAAIAKTFGLTVPQ---ALQTGTLfflGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLAL 114
Cdd:PRK11551 33 SAGVAAPRMAQEFGLDVAQmgwAFSAGIL---GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 115 RFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWL-VMLEGFWAVGtvviAIAAWATSVAGVEDAWRYIFIV-TAAPALIGIW 192
Cdd:PRK11551 110 RLLTGVGLGGALPNLIALTSEAVGPRLRGTAVsLMYCGVPFGG----ALASVIGVLAAGDAAWRHIFYVgGVGPLLLVPL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 193 LRFRVPESPMHLLKSGRveeakavinlvlsrnGKPELPPGAKLLAPRlvtnerllspnlrqRTLTSLAIW---FLVSVSY 269
Cdd:PRK11551 186 LMRWLPESRAFAQAAGA---------------GKQRAPVLRALFGEG--------------RATATLLLWisyFFTLIVL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 270 YGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASIL 349
Cdd:PRK11551 237 YFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGF 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 350 IMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAG--LLALAGIIAF 424
Cdd:PRK11551 317 AAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASipVILVAALAAL 393
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-393 |
1.24e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.15 E-value: 1.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 14 TGSFQRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVA 93
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 94 CDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGv 172
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALgPLLGGLLADLFG- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 173 edaWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINlvlsrngkpelppgakllaprlvtnerllspnlR 252
Cdd:COG2814 163 ---WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR---------------------------------R 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 253 QRTLTSLAIWFLVSVSYYGIFTWIPAKLASD-GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAA 331
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 332 CALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLA 393
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
63-418 |
2.39e-29 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 117.16 E-value: 2.39e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR 142
Cdd:cd17375 43 IFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKAR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 143 GRWLVMLEGFWAVGTVVIAIAAWAtsvagVEDAWRY--IFIVTAAPALIGIWLrfrvpespmhllksgrveeakavinlv 220
Cdd:cd17375 123 TWASMHVHAFFAVGIMVVALVGYL-----VRTWWIYqiILSLVTIPFILCCWM--------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 221 lsrngkpelppgakllaprlvtnerllspnLRQRTLTSLAIWFLVSVSYYgIFTWIPAKLASDGfgfvrgYGFLVVVALA 300
Cdd:cd17375 171 ------------------------------LPKRTITVWLIWFTGSLGYY-VFSLGSVNLGGNE------YLNLFLVGAV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 301 QLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMS--FALLGTWGALYAFTPELYPTALRASG 378
Cdd:cd17375 214 EIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMTgkFAIAIAFGLIYLYTAELYPTIVRSLA 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 489055956 379 MGAAGAMARLGGLLAP-----SAMAVVINQSFYTAVAMFAGLLAL 418
Cdd:cd17375 294 VGSGSMMCRVGSVVAPfcvylSDVWIFLPQLLVGIMAFLSGILTL 338
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
21-426 |
2.62e-29 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 117.60 E-value: 2.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 21 LLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGL 100
Cdd:cd17442 2 LFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 101 LSAFAPDFGSLLALRFLTGLAVGGTlPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAwatSVAGVEDAWRYIF 180
Cdd:cd17442 82 LTSFAPSYIWFVFLRCMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLA---SVVIPTLGWRWLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 181 IVTAAPALIGIWLRFRVPESPMHLLksgrveeakaVINLVLSRNGKPELPPGAKLLAPRLVTNERLLSPNLRQRTLTSla 260
Cdd:cd17442 158 RFASIPGIILIVVFKFIPRTTLQIW----------VIWLGISFAYYGVILASSELLERNLLCGSDPSDEEAGIKHIES-- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 261 iwflVSVSYYGIFTwipaklASDgfgfvrgYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATS 340
Cdd:cd17442 226 ----ESPCYCHMFN------PSD-------YQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTS 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 341 SSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAG 420
Cdd:cd17442 289 SAGLTIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCA 368
|
....*.
gi 489055956 421 IIAFFI 426
Cdd:cd17442 369 ISAFTL 374
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
60-418 |
1.53e-26 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 109.43 E-value: 1.53e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:cd17447 40 TATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 140 KNRGRWLVMLEGFWAVGTVVIAIAAWAtsvagVEDaWRYIFIVTAAPALIGIWLRFRVPespmhllksgrveeakavinl 219
Cdd:cd17447 120 EHRTVAGVLISLFWTVGNMLLALVAYL-----IRD-WRWLILAVTLPCAPGIITWWWVP--------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 vlsrngkpelppgakllaprlvtnerllspnlrQRTLTSLAIWFLVSVSYYGIftwipaKLASDGFGfVRGYGFLVVVAL 299
Cdd:cd17447 173 ---------------------------------KISLCTGIVWFGVAFTYYGI------SFNISGFG-LNVYLTQFIYGA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 300 AQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFT-VATSSSVVGASILIMSFALLGT-WGALYAFTPELYPTALRAS 377
Cdd:cd17447 213 IELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINIlIPSEFTVVRTVIAVLGKGFSEAaFTTVFLYTSELYPTVLRQN 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489055956 378 GMGAAGAMARLGGLLAPsaMAVVIN-------QSFYTAVAMFAGLLAL 418
Cdd:cd17447 293 GMGYTSFIARLGGSLAP--LVILLDdvwlslpQVIFCGVALLAGGVAF 338
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
62-418 |
8.44e-26 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 106.99 E-value: 8.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRH 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 142 RGRWLVMLEGFWAVGTVVIAIAAWATSvagvedAWRYIFIVTAAPALIGIwlrfrvpespmhllksgrveeakavinlvl 221
Cdd:cd17374 122 RALAITLTSCFFSIGQMLLAGLAYAIR------DWRLLQLVVSVPFFLFF------------------------------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 222 srngkpelppgakllaprlvtnerLLSPNLRQRTLTSLAIWFLVSVSYYGIftwipaKLASDGFGfVRGYGFLVVVALAQ 301
Cdd:cd17374 166 ------------------------LYSWWLPKRTLILSFVWFANSFSYYGL------SLDLQHLG-LNVFLLQFLFGAVE 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 302 LPGYALAAYGVEAWGRRKTLIGFLFVSAAAC-ALFTVATSSSVVGASILIMS-FALLGTWGALYAFTPELYPTALRASGM 379
Cdd:cd17374 215 VPARCLALFLLNHMGRRISQAVLLLLAGLCIlANIFVPQEMQTLRTVLAVLGkGSSAAAFTISYVYTAELFPTVLRQTGM 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489055956 380 GAAGAMARLGGLLAPSAMA-----VVINQSFYTAVAMFAGLLAL 418
Cdd:cd17374 295 GLNSMFARIGGILAPLIMLlgvysPLLPMIIYGVLPILAGLLAL 338
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
61-394 |
2.86e-24 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 102.93 E-value: 2.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 61 GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFlpak 140
Cdd:cd17377 45 SSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNEC---- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 141 nrgrwlvmlegfwaVGTVVIAIAAWATSVagvedawryIFIVTAAP-ALIGIWLRfrvpesPMHLLKsgrveeakAVINL 219
Cdd:cd17377 121 --------------VGKSYWALAGSLGGL---------FFAVGIAQyALLGYFIR------SWRTLA--------VVVNL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 vlsrngkpelpPGAKLLaprlvtnerLLSPNLRQRTLTSLAIWFLVSVSYYGIfTWIPAKLASDGFGFVRGYGflvvvaL 299
Cdd:cd17377 164 -----------QGTLVF---------LLSLFIPGRTLILMYVWFVCSLVYYGL-TLNAGDLGGNIYLNLALSG------L 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 300 AQLPGYALAAYGVE-AW-GRRKTLIGFLFVSAAACAL--FTVATSSSVVGASILIMSFALLG------TWGALYAFTPEL 369
Cdd:cd17377 217 VELPAYPLCIYLINqKWsGRRRTLAGFLFLGGIACLLvmFVPEKKDSGVFAVVNSTSLSLLGkltisaAFNIVYIYTSEL 296
|
330 340
....*....|....*....|....*
gi 489055956 370 YPTALRASGMGAAGAMARLGGLLAP 394
Cdd:cd17377 297 YPTVVRNAGLGVCSMFSRVGGIIAP 321
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
63-431 |
4.29e-23 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 101.26 E-value: 4.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLITVAC---DALFGLLSAFAPDFGSLLALRFLTGLAVGG--TLPVDYAmmAEFL 137
Cdd:TIGR00879 79 IFLVGGFIGALFAGWLSDRFGRKKSLLIIALLfviGAILMGLAAFALSVEMLIVGRVLLGIGVGIasALVPMYL--SEIA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 138 PAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVi 217
Cdd:TIGR00879 157 PKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKS- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 218 nLVLSRNGKPELPPGAKLLA-------------PRLVTNERLLSPNLRQRTLTSLAI-WFLVSVSYYGIFTWIPAKLASD 283
Cdd:TIGR00879 236 -LARLRGTSGEDKELLDELElidikrsiekrsvQPSWGSLFSSTRRIRRRLFLGVVLqWFQQFTGINAIMYYSPTIFENA 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 284 GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGT--WGA 361
Cdd:TIGR00879 315 GVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGSSKSSGNVAIVFIllFIA 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 362 LYAFTP---------ELYPTALRASGMGAAGAMARLG----GLLAPSAMAVVINQSFYTavaMFAGLLALAGIIAFFINV 428
Cdd:TIGR00879 395 FFAMGWgpvpwvivsEIFPLSLRPKGISIAVAANWLAnfivGFLFPTMLESIGVGGVFI---FFGGLNVLGLIFVYFFLP 471
|
...
gi 489055956 429 ETR 431
Cdd:TIGR00879 472 ETK 474
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-394 |
8.56e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 8.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIV 182
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALgPLLGGLLASLFG----WRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 183 TAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVInlvlsrngkpelppgakllaprlvtneRLLSPNLRQRTLTSLAIW 262
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI---------------------------VAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 263 FLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTL---IGFLFVSAAACALFTVAT 339
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllaLLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489055956 340 SSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAP 394
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-434 |
1.03e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.10 E-value: 1.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 18 QRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDAL 97
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 98 FGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIA-IAAWATSVAGvedaW 176
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAfLAPLLIAAFG----W 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 177 RYIFIVTAAPALIGiwlrfrvpespmhllksgrveeakAVINLVLSRNGKPELPPGAKllaprlvTNERLLSPNLRQRTL 256
Cdd:COG2223 159 RNAFLILGILLLVV------------------------AVLAWLFLRDPPAGAAAAAK-------ASLRDQLEALRDPRF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 257 TSLAIWFLVSV-SYYGIFTWIPaKLASDGFGF--VRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACA 333
Cdd:COG2223 208 WLLSLLYFGTFgSFIGFSSWLP-PYLVDQFGLsaATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 334 LFTVATSSSVVGASILIMSFALLGTW-GALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQ--SFYTAVA 410
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFL 366
|
410 420
....*....|....*....|....
gi 489055956 411 MFAGLLALAGIIAFFINVETRQQA 434
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
62-424 |
5.42e-21 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 93.58 E-value: 5.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLAD-KYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17378 40 SSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 141 NRGRWLVMLEGFWAVGTVVIAIAAWATSvagveDAWRYIFIVTAAPALIGIwlrfrvpespmhllksgrveeakavinlv 220
Cdd:cd17378 120 WRGQVGMSTFFFFVLGFMSLPGIAYLNG-----SSWRVLYFWTSIPALIYC----------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 221 lsrngkpelppgakllaprlvtnerLLSPNLRQRTLTSLAIWFLVSVSYYGIftwipaKLASDGFGFVRGYGFlVVVALA 300
Cdd:cd17378 166 -------------------------ILVYLFARRLLAVMVIGFGIGMVYYGI------PLAVGNLKFNIYLSV-ALNALS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 301 QLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASI---LIMSFALLGTWGALYAFTPELYPTALRAS 377
Cdd:cd17378 214 ELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIaleLVGFFGAAGAFNLLYIYTVELFPTCVRNA 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489055956 378 GMGAAGAMARLGGLLAPSAMAVVINQSFYTaVAMFAGLLALAGIIAF 424
Cdd:cd17378 294 ALGMLRQALVVGGIFAPFIVSLGRKNAALS-FGVFGVAILLLGLFAL 339
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
45-425 |
1.37e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 92.61 E-value: 1.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 125 TLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIVTAAPALIG-IWLRFRVPESPm 202
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLgRPLGGLLGQLLG----WRAAFLAIAVLALLAaLLLWRLLPSLP- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 203 hllksgrveeakavinlvlsrnGKPELPPGAKLLAPRLVTNERLLSpnlrqrtltSLAIWFLVSVSYYGIFTWIPAKLAS 282
Cdd:cd17324 179 ----------------------PKKPGSLGLLSSLLLLLRNPRLRL---------AYLITFLLFGGFFALYTYLAPFLTD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 283 DGFGFVRGY-GFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGA 361
Cdd:cd17324 228 VPGFSSSAIiGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489055956 362 LYAFTPELYPTAlRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFF 425
Cdd:cd17324 308 LQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-426 |
7.11e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.71 E-value: 7.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 142 RGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIVTAAPALIGIWLRFRVPEspmhllksgrveeakavinlv 220
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIgPLLGGLLADALG----YRAPFLVCAALALLALVLALLLLP--------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 221 lsrngkPELPPGAKLLAPRLVTNERLLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLV-VVAL 299
Cdd:cd17325 173 ------EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFgAQGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 300 AQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGM 379
Cdd:cd17325 247 ASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489055956 380 GAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
62-426 |
9.72e-20 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 89.78 E-value: 9.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 142 RGRWLVMLEGFWAVGTVVIAIAAWATSvagvedAWRYIFIVTAAPALIGIWLRFRVPEspmhllksgrveeakavINLVL 221
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIR------DWRWLQLAVSLPFFIFFLYSWWFPR-----------------ITFCL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 222 SrngkpelppgakllaprlvtnerllspnlrqrtltslAIWFLVSVSYYGiftwipakLASD--GFGfVRGYGFLVVVAL 299
Cdd:cd17446 177 S-------------------------------------LVWFSTSFAYYG--------LAMDlqKFG-VSIYLIQIIFGA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 300 AQLPGYALAAYGVEAWGRRKTLIGFLFVSAAAC--------ALFTVATSSSVVGASILIMSFAllgtwgALYAFTPELYP 371
Cdd:cd17446 211 VDIPAKFISTLTMSYLGRRPTQAAALILAGIMIlanifvpqDLQTVRTALAVFGKGCLAASFN------CVYLYTGELYP 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 372 TALRASGMGAAGAMARLGGLLAPsamAVVINQSFYTAVA--MFAGLLALAGIIAFFI 426
Cdd:cd17446 285 TVIRQTGMGLGSTMARLGGIVAP---LVKMLGEYYPFLPliIYGAAPILSGIAACFL 338
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
45-427 |
1.71e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.53 E-value: 1.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 125 TLPVDYAMMAEfLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALigiwlrfrvpespmhl 204
Cdd:COG0738 113 LDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLL---------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 205 lksgrveeakaVINLVLSRNGKPELPPGAKLLAPRLVTNERLLSpnlRQRTLTSLAIWFLVSVSYYGIFTWIPaKLASDG 284
Cdd:COG0738 176 -----------LLALLFLRSKLPEIEEEEEEAAGSAASLKSLLK---NPRLLLGGLAIFLYVGAEGAIGDWLP-LYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 285 FGFVRGYG--FLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGAL 362
Cdd:COG0738 241 LGLSEATAalGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489055956 363 YAFTPELYPTAlRASGMGAAGAMARLGGLLAPSAMAVVINQ-SFYTAVAMFAGLLALAGIIAFFIN 427
Cdd:COG0738 321 FSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAfGLRAAFLVPLVCYLLILLLALALK 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-302 |
2.19e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 87.94 E-value: 2.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 18 QRGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDAL 97
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 98 FGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGvedAWR 177
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL---GWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 178 YIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVLSRNGKPELPPGAKLLAPRLVTNERLLSPNLRQRTLT 257
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489055956 258 SLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQL 302
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-426 |
2.27e-19 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 88.78 E-value: 2.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 38 AVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFL 117
Cdd:cd17319 21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 118 TGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIA-IAAWATSVAGvedaWRYIFIVTAAPALI-GIWLRF 195
Cdd:cd17319 101 LGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFG----WRWAFIIEGLLGLLlAVLWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 196 RVPespmhllksgrveeakavinlvlsrngkpelppgakllaprlvtnerllspnlrqRTLTSLAIWFLVSVSYYGIFTW 275
Cdd:cd17319 177 YLR-------------------------------------------------------QVWGLALGYFGINYALYGLLTW 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 276 IPAKLASdgfgfVRGYGFLVVVALAQLPgYALAAYGVEAWG----------RRKTLIGFLFVSAAACALFTVATSSSVVG 345
Cdd:cd17319 202 LPTYLKQ-----ARGFSLKQVGLLAAIP-FLAGAIGMILGGrlsdrllrgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 346 ASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQ--SFYTAVAMFAGLLALAGIIA 423
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLV 355
|
...
gi 489055956 424 FFI 426
Cdd:cd17319 356 LLL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-425 |
3.77e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 3.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 25 FGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 105 APDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATsVAGVEDAWRYIFIVTA 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-ASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 185 APALIGIWLRFRVPESPmhllksgrveeakavinlvlsrngkPELPPGAKLLAPRLVTNERLLSPNLRQRTLTSLAIWFL 264
Cdd:cd06174 160 ALALLAAILLLLVVPDP-------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 265 VSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVV-ALAQLPGYALAAYGVE-AWGRRKTLIGFLFVSAAACALFTVATSSS 342
Cdd:cd06174 215 VNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLfGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 343 VVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSF-YTAVAMFAGLLALAGI 421
Cdd:cd06174 295 LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAA 374
|
....
gi 489055956 422 IAFF 425
Cdd:cd06174 375 ILLL 378
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-431 |
4.48e-19 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 88.86 E-value: 4.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVA---CDALFGLLSAFAPDFGSLLALRFLTGLAVG---GTLPVdyaMMAEFL 137
Cdd:cd17357 58 FFIGGAIGSFISAFLANRFGRKNGLLISNAllvVSSLLMFLSKSAKSPELLIFGRFLVGIACGlstGFVPM---YLQEIS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 138 PAKNRGRWLVMLEGFWAVGTVVIAIAAWAtSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKS-GRVEEAKAV 216
Cdd:cd17357 135 PSELRGALGSLTQIGVTLGILLGQVFGLP-SVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEEEAEKS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 217 INLVlsRNGKPELPPGAKLLAPRLVTNER---------LLSPNLRQRTLTSLAIWF------LVSVSYYGI-------FT 274
Cdd:cd17357 214 LKFL--RGIEDDVDQELEEIKKESEQMGDqkqvslmqlLRDPSLRLPLLLVLVVSAsqqfsgINAIFFYSTfifenagFS 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 275 WIPAKLASDGFGFVrgygfLVVVALaqlpgyaLAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSvvgASILIMSFA 354
Cdd:cd17357 292 PQLAEWANLGIGIV-----NVLSTI-------VGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLS---EQNSWMSYG 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 355 LLG---TWGALYAF---------TPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGII 422
Cdd:cd17357 357 CIVaifLFIFFFAIglgpipwfiGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLY 436
|
....*....
gi 489055956 423 AFFINVETR 431
Cdd:cd17357 437 LYRYLPETK 445
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
42-209 |
5.47e-19 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 88.01 E-value: 5.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 42 TGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLA 121
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 122 VGGTLPVDYAMMAEFLPAKNRGRWLVMLE-----GFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFR 196
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQlmivfGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLF 182
|
170
....*....|...
gi 489055956 197 VPESPMHLLKSGR 209
Cdd:cd17359 183 IPESPRWLVSKGK 195
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
37-431 |
1.46e-18 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 87.25 E-value: 1.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 37 LAVGFTGAAIAK-------TFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFG 109
Cdd:cd17358 16 IAVGWSSPALPSlmsdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 110 SLLALRFLTGLAVGG---TLPVdyaMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSvagvedaWRYIFIVTAAP 186
Cdd:cd17358 96 MLYLGRFLAGFGGGAasvVVPV---YIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-------WRTLALIGAIP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 187 ALIGIWLRFRVPESPMHLLKSGRVEEAKAVINLVlsRNGKPELPPGAKLLAPRLVTNERLLSPN-----LRQRTLTSLAI 261
Cdd:cd17358 166 PVVFLILLFFIPESPRWLAKKGREEEAEKSLQFL--RGKDADISKEAAEIQEELAELEKEAKESsfsdlFQRKYLKPLVI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 262 WFLVSVSY-----YGIFTWIPAKLASDGFGFVRGYGFlVVVALAQLPGYALAAYGVEAWGRRKTLIgflfVSAAACALFT 336
Cdd:cd17358 244 GLGLMLFQqlsgiNAVIFYASSIFDEAGSGLDPNTAT-IIIGVVQVVGTLVATLLVDRLGRRPLLL----VSAIGMGIGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 337 VATSSS-----------------VVGASILIMSFAlLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAM-A 398
Cdd:cd17358 319 LALGLYfylqehgallssvswlpLVGLVIYIISFS-IGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFpF 397
|
410 420 430
....*....|....*....|....*....|...
gi 489055956 399 VVINQSFYTAVAMFAGLLALAGIIAFFINVETR 431
Cdd:cd17358 398 LTLAWGASGTFWIFAGICGLALVFVLLFVPETK 430
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
45-426 |
2.40e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 86.09 E-value: 2.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 125 TLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATsvagVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHl 204
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL----AAISWRYPFFLLAALIPVAFLAILFLLPEPKE- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 205 lksgrveeakavinlvlsrngKPELPPGAKLLAPRLVTNERLLspnlrqrtLTSLAIWFLVSVSYYGIFTWIP--AKLAS 282
Cdd:cd17474 179 ---------------------KAKSSSATKLRDLKKALRGRGL--------LTFLVSAFLYFFLYFAFLTYLPflLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 283 DGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGAL 362
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489055956 363 YAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
56-423 |
6.21e-18 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 85.27 E-value: 6.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 56 QALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITV----ACDALFGLLsafaPDFGS--------LLALRFLTGLAVG 123
Cdd:cd17369 45 AAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLllmgIATFLIGLL----PTYAQigilapilLVLLRLLQGLALG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 124 GTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDA-----WRYIFIVTAAPALIGIWLRFRVP 198
Cdd:cd17369 121 GEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAflswgWRIPFLLSAVLVAVGLYIRLRLE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 199 ESPMHLLKSGRVEEAKAVINLVLSRNGKPelppgakllaprlvtnerllspnlrqrTLTSLAIWFLVSVSYYGIFTWIPA 278
Cdd:cd17369 201 ETPVFRRAKEAGQVVRAPLVEVLRRHWRA---------------------------LLLAIGLRLAENVLFYLFTTFALS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 279 KLAS-DGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLI-GFLFVSAAACALFTVATSSS---VVGASILIMSF 353
Cdd:cd17369 254 YATQtLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLaGALLAALFAFPFFWLLDTGStwlIVLAAVVVLGV 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 354 ALLGTWGALYAFTPELYPTALRASGMGAAGAM-ARLGGLLAPSAMAVVINQSF-YTAVAMFAGLLALAGIIA 423
Cdd:cd17369 334 LHGMMYGPQAAFLAELFPTRVRYTGASLGYQLgAILGGGFAPLIATALVAATGsWWPVALYLAALAVISLVA 405
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
60-394 |
4.83e-16 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 79.05 E-value: 4.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:cd17376 40 TTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 140 KNR---GRWLVMLegFWAVGTVVIAIAAWATSvagvedAWRYIFIVTAAPALIGIWLRFRVPESpmhllksgrveeakav 216
Cdd:cd17376 120 SVRilfSTLGVCI--FYAIGYMLLPLFAYFIR------DWRMLLLALTLPGVLCVPLWWFIPIT---------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 217 inlvlsrngkpelppgakllaprlvtnerllspnlrqrTLTSLAIWFLVSVSYYGIFTWIPaKLASDGfgfvrgYGFLVV 296
Cdd:cd17376 176 --------------------------------------TIMSLLLWMAISVGYFGLSLNTP-NLHGDP------YLNCFL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 297 VALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIM--SFALLGTWGALYAFTPELYPTAL 374
Cdd:cd17376 211 SAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMlgKFGITAAFSMVYVYTAELYPTVV 290
|
330 340
....*....|....*....|
gi 489055956 375 RASGMGAAGAMARLGGLLAP 394
Cdd:cd17376 291 RNMGVGVCSTASRIGSIISP 310
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
53-386 |
8.76e-16 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 78.88 E-value: 8.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 53 TVPQALQTGTLFFLGML---VGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--------LLALRFLTGLA 121
Cdd:cd17367 35 PTVALLSTAAVFAVGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 122 VGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGVED----AWRYIFIVTAAPALIGIWLRFR 196
Cdd:cd17367 115 VGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLaLGVLLVLQHTLGEDQmaawGWRIPFLLGGVLAVVVLWLRRG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 197 VPESPMHLLKSGRVEEakavinlvlsrngkpelppgakllaprlvtnERLLSPNLRQRTLTSLAIWFLV---SVSYYGIF 273
Cdd:cd17367 195 LEETESFEAIAESNEA-------------------------------SAGTLRELRRHPRELLLVVGLTaggTLAFYTWT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 274 TWIPaKLASDGFGFVRG------YGFLVVVALAQLPGYALAaygvEAWGRRKTLIGF--LFVSAAACALFTVATSSSVVG 345
Cdd:cd17367 244 TYLQ-KFLVNTAGFSKGdatwitTAALLVFMLLQPLGGRLS----DRIGRRPLLLFFgiGGTLATVPLLSALDHTDSPYT 318
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 489055956 346 ASILIM-SFALLGTWGALYA-FTPELYPTALRASGMGAAGAMA 386
Cdd:cd17367 319 AFALVLvGLVFLSGYTSINAvVKAELFPTHVRALGVGLPYALA 361
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
46-426 |
2.95e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 77.28 E-value: 2.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 126 LPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVviaIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPmhll 205
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNI---IAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESK---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 206 ksgRVEEAKavinlvLSRNGKPELPPGAKLLAPRLVTnerllspnLRQRTLTSLAIWFLVSVSYYG----IFTWIPAKLA 281
Cdd:PRK12307 197 ---EWEEAK------LSGKGKHSQSAWSVFSLSMKGL--------FNRAQFPLTLCVFIVLFSIFGanwpIFGLLPTYLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 282 SDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTL-IGFLFVSAAACALFTVAT-SSSVVGASILIMSFALLGTW 359
Cdd:PRK12307 260 GEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFsIGLLMSFLFIFPLFRIPQdNYLLLGACLFGLMATNVGVG 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 360 GALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAmAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:PRK12307 340 GLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMA-ATWLGITMGLGAALTFIVAFWTATILLII 405
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
62-426 |
1.15e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.92 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17473 42 TLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 142 RGRWLVMLEGFWAVG-TVVIAIAAWATSVagvedAWRYIFIVTAAPALIGIWLRFRVPESPmhllksgrveeakavinlv 220
Cdd:cd17473 122 RAKMLGLQSAAMSLGgVVFLLLGGALAEI-----GWRAPFLVYLLALPVLILVLLFLPEPA------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 221 lsRNGKPELPPGAKLLAPRLVtnerllspnlrQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLV-VVAL 299
Cdd:cd17473 178 --RKSKSAASPGAATAAALPW-----------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALaIASL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 300 AQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGM 379
Cdd:cd17473 245 AGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAM 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489055956 380 GAAGAMARLGGLLAPSAMAVVINQSF-YTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17473 325 GIVTSAFFLGQFLSPLVLGPLVNLTGgLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
65-430 |
1.65e-14 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 74.62 E-value: 1.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 65 FLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPD------FGSLLALRFLTGLAVGGTLPVDYAMMAEFLP 138
Cdd:cd17364 49 LVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYAN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 139 AKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAG-----------VEDAWRYIFIVTAAPALIGIWLRFRVpespmhllks 207
Cdd:cd17364 129 KKRRGALIAAVFAMQGFGILAGAIVTLILSAIFehplpagtyhhADLVWRIVLGLGAIPALSVLYFRKHL---------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 208 grveeakavinlvlsrngkpelppgakllaprlvtnerllspnlrqrtLTSLAIWFLVSVSYYG-------IFT---WIP 277
Cdd:cd17364 199 ------------------------------------------------LGTAGTWFLLDIAFYGqnlfqstIISaigFSK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 278 AKLASDGfGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLI-GF----LFVSAAACALFTVATSSsvVGASILIMS 352
Cdd:cd17364 231 TMNAYQE-LFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMmGFfgmtIFLLILAGPYDHWKIST--IGFFVLYGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 353 FALLGTWGA---LYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFINVE 429
Cdd:cd17364 308 TFFFSNFGPnttTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPE 387
|
.
gi 489055956 430 T 430
Cdd:cd17364 388 E 388
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
46-398 |
4.42e-14 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 73.99 E-value: 4.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFfLGMLVGAALFGRLADKYGRRRI----LLITVACDALFGLLSAFAPDF--GSLLALRFLTG 119
Cdd:TIGR00887 48 HGKGPLPSSVSAAVNGSAS-IGTLAGQLFFGWLADKLGRKRVygmeLIIMIIATVASGLSPGSSPKSvmATLCFWRFWLG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 120 LAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAA--------------------WATSVAGVEDAWRYI 179
Cdd:TIGR00887 127 VGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVAlivlagfkhsleaaadeascTGSCVPAVDYMWRIL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 180 FIVTAAPALIGIWLRFRVPESPMHLLKSGR-VEEAKAVINLVLSRN--GKPELPPGAKLLAPRLVTNERLLSPNLRQRT- 255
Cdd:TIGR00887 207 IGFGAVPALLALYFRLTIPETPRYTADVAKdVEQAASDMSAVLQVKieAEPDEVEKASTAVEVPKASWSDFFTHFFKWRh 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 256 ----LTSLAIWFLVSVSYYG-------IFT---WIPAKLASDGFGFVR--GYGFLVVVALAQLPGYALAAYGVEAWGRRK 319
Cdd:TIGR00887 287 gkhlLGTAGSWFLLDIAFYGvnlnqkvILSaigYSPPAATNNAYEELYktAVGNLIIALAGTVPGYWVTVFLVDIIGRKP 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 320 -TLIGFLFVSAAACAL---FTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPS 395
Cdd:TIGR00887 367 iQLMGFFILTVLFFVLgfaYNHLSTHGFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQF 446
|
...
gi 489055956 396 AMA 398
Cdd:TIGR00887 447 GFL 449
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
66-394 |
5.90e-14 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 72.77 E-value: 5.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 66 LGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRW 145
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 146 LVMLEGFWAVGTVVIAIAAWATSvagvedAWRYIFIVTAAPALIGIWLRFRVPespmhllksgrveeakavinlvlsrng 225
Cdd:cd17379 124 GIVYQMFFTLGLLILPGIAYFIP------HWRWLQLAVTLPNFLFLLYYWFIP--------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 226 kpelppgakllaprlvtnerllspnlrQRTLTSLAIWFLVSVSYYGIFTWIpaklasdgfGFVRGYGFL--VVVALAQLP 303
Cdd:cd17379 171 ---------------------------KHTFILMYAWFTSAVVYQGLIMRL---------GITGGNLYLdfFISALVELP 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 304 GYALAAYGVEAWGRRKTLIGFLFVSAAACaLFTVATSSSVvgaSILIMSFALLGTWGALYAF------TPELYPTALRAS 377
Cdd:cd17379 215 AAFIILLTIDRIGRRLPFAASNIVAGAAC-LITAFIPPDL---HWLKTTIACVGRLGITMAFeivclvNTELYPTFLRNL 290
|
330
....*....|....*..
gi 489055956 378 GMGAAGAMARLGGLLAP 394
Cdd:cd17379 291 GVSVCSSLCDIGGIIAP 307
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
40-435 |
1.18e-13 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 72.44 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 40 GFTGAAIAKTF------GLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--- 110
Cdd:PRK10642 36 GFVAYALGKVFfpgadpSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigi 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 111 -----LLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR---GRWLVM--LEGFWAVGTVVIAIAAWATSVAGVEDAWRYIF 180
Cdd:PRK10642 116 wapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRgfmGSWLDFgsIAGFVLGAGVVVLISTIVGEANFLDWGWRIPF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 181 IVTAAPALIGIWLRFRVPESPMHLLKSGRVEEAkavinlvlSRNGkpelppgakLLAPRLVTNERLLSPNLRQrTLTSLA 260
Cdd:PRK10642 196 FIALPLGIIGLYLRHALEETPAFQQHVDKLEQG--------DREG---------LQDGPKVSFKEIATKHWRS-LLTCIG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 261 IWFLVSVSYYGIFTWIPAKLaSDGFGFVRGYGFLVVVA--LAQLPGYALAAYGVEAWGRRKtligflFVSAAACALFTVA 338
Cdd:PRK10642 258 LVIATNVTYYMLLTYMPSYL-SHNLHYSEDHGVLIIIAimIGMLFVQPVMGLLSDRFGRRP------FVILGSVALFVLA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 339 ------TSSSVVG---ASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMA--VVINQSFYT 407
Cdd:PRK10642 331 ipafilINSNVIGlifAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAwlVESTQNLMM 410
|
410 420
....*....|....*....|....*...
gi 489055956 408 AvAMFAGLLALAGIIAFFINVETRQQAL 435
Cdd:PRK10642 411 P-AYYLMVVAVIGLITGVTMKETANRPL 437
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
64-429 |
1.63e-13 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 71.45 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRG 143
Cdd:cd17315 43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 144 RWLVMLEGFWAVGTVVIAIAAWATSVaGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSG-RVEEAKAVINLVLS 222
Cdd:cd17315 123 ALGTLNQLMITFGILLAYLLGLALSL-SPPGWWRLMFALAAVPALLQLLLMFFLPESRALLVGVGlQLLQQLTGINAVMY 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 223 rngkpelppgakllaprlvtnerlLSPNLRQRTLTSLAiwflvsvsyygiftwipAKLASdgfgfvrgygflVVVALAQL 302
Cdd:cd17315 202 ------------------------YAPTIFKSAGGGTA-----------------SILAS------------IIVGVVNL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 303 PGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSS----------SVVGASILIMSFALlgTWGALYAF-TPELYP 371
Cdd:cd17315 229 LATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLpalakaagwlALLGILLYIAAFAM--GAGPVPWLlLSEIFP 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 372 TALRASGMGAAGAMARLggllapsaMAVVINQSFYTAVA---------MFAGLLALAGIIAFFINVE 429
Cdd:cd17315 307 LRIRGKGMAIATLVNWI--------FNFIVGLTFLIMVStiglagvfiFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-201 |
2.43e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.07 E-value: 2.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 44 AAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVG 123
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 124 GTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVI-AIAAWATSVAGvedaWRYIFIVTAAPALI-GIWLRFRVPESP 201
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALApLLGGLLLLFFG----WRAIFVFLALLGLLlLLLVLLFLPETL 178
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
44-426 |
9.31e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 69.14 E-value: 9.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 44 AAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAvG 123
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-G 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 124 GTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIVTAAPALIGIWLrfrVPESPM 202
Cdd:cd17504 99 AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIgLPLGGWIVQHLG----WRWIFWTAAPVAVLLAAL---VPLIDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 203 HLLKsgrveeakavinlvlsrngkpelppgakllaprlvtnerllspnlRQRTLTSLAIWFLVSVSYYGIFTWIPAKLAS 282
Cdd:cd17504 172 RLLR---------------------------------------------RRNVLLANITALLAGFGMFMVFQLLPQLLQL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 283 D-----GFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTL-IGFLFVSAAACALFTVATSSSVVGASILIMSFALL 356
Cdd:cd17504 207 PtptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLlIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLG 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 357 GTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVI--------------NQSFYTAVAMFAGLLALAGII 422
Cdd:cd17504 287 LAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILttytvsitsggvptEGAYVLAFLIGAALALAALLL 366
|
....
gi 489055956 423 AFFI 426
Cdd:cd17504 367 SLLI 370
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
66-201 |
1.50e-12 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 68.45 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 66 LGMLVGAALFGRLADKYGRRRILLItvaCDALF---GLLSAFAPDFGSLLALRFLTGLAVG---GTLPVdyaMMAEFLPA 139
Cdd:cd17360 46 AGAAVGAAIGGWLNDRFGRRPCILL---ADALFtigAIVMAAAPNKEVLIVGRVLVGLGVGiasMTVPL---YIAEAAPP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489055956 140 KNRGRwLVMLEGFWAVGTVVIA-IAAWATSVagVEDAWRYIFIVTAAPALIGIWLRFRVPESP 201
Cdd:cd17360 120 RIRGR-LVTINVLFITGGQFVAyVINGAFSY--LPGGWRWMLGLAAVPAVLQFIGLLFLPESP 179
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
66-426 |
3.16e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 67.64 E-value: 3.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 66 LGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRW 145
Cdd:cd17329 46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 146 LVMLEGFWAVGTVV-IAIAAWAtsvagVEDAWRYIFIVTAA-PALIGIWLRFRVPESpmhllksgrveeakavinlvlsR 223
Cdd:cd17329 126 FSLLYWAINLGVAIgPLLGGLL-----LLYSFRLLFLAAAVlFLLAALVLLFLLPET----------------------R 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 224 NGKPELPPGAKLLAPRLVTNERllspnlrqRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFL-----VVVA 298
Cdd:cd17329 179 PKRRAAEKTEILRGYKIVLRDR--------AFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLlalnaLLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 299 LAQLPgyalAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASG 378
Cdd:cd17329 251 LLQFP----VARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSY 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489055956 379 MGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17329 327 MGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-426 |
5.33e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.21 E-value: 5.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 8 TLDQAGTGSFQRGLLGIFGLVWAADAM--QVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRR 85
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLrpAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 86 RILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKnrgRWLVMleGFWAVG-TVVIAIAA 164
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR---VGLMT--GLYTAAmGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 165 WATSVAGVEDAWRYIFIVTAAPALIGiwlrfrvpespmhllksgrveeakAVINLVLSRNGKPELPPGAKLLAPRLVtne 244
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLA------------------------LLLWLPLLRRRPAAAAAAPAAASLRSL--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 245 rllspnLRQRTLTSLAIWF-LVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWG-RRKTLI 322
Cdd:COG2807 212 ------WRSPLAWLLTLFFgLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 323 GFLFVSAAACALFTVATSSSVVGASILImSFALLGTWGALYAFTPELYPTALR-ASGMGAAGAMARLGGLLAPSAMAVV- 400
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWAVLL-GLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALh 364
|
410 420
....*....|....*....|....*..
gi 489055956 401 -INQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:COG2807 365 dATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
51-384 |
6.14e-12 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 67.03 E-value: 6.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 51 GLTVPQALqtgtlffLGMLVGAALFGRLADKYGRRRILLITvacdALFGLLSAFA-------------PDFGSLLAL--- 114
Cdd:PRK10077 58 GFCVASAL-------IGCIIGGALGGYCSNRFGRRDSLKIA----AVLFFISALGsawpefgftsigpDNTGYVPEFviy 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 115 RFLTGLAVGGTLPVDYAMMAEFLPAKNRGRwLVMLEGFWAV-GTVVIAIAAWATSVAG-----VEDAWRYIFIVTAAPAL 188
Cdd:PRK10077 127 RIIGGIGVGLASMLSPMYIAEIAPAHIRGK-LVSFNQFAIIfGQLVVYFVNYFIARSGdaswlNTDGWRYMFASEAIPAL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 189 IGIWLRFRVPESPMHLLKSGRVEEAKAVINLVL-SRNGKPELPPGAKLLAPRLVTNERLLSPNLrqrtltsLAIWFLVSV 267
Cdd:PRK10077 206 LFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMgNTLATQALQEIKHSLDHGRKTGGKLLMFGV-------GVIVIGVML 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 268 SYYGIFTWIPAKL--ASDGF---GFVRGYGFL--VVVALAQLPGYALAAYGVEAWGRRKTLI-GFLFVSAAACAL---FT 336
Cdd:PRK10077 279 SVFQQFVGINVVLyyAPEIFktlGASTDIALLqtIIVGVINLTFTVLAIMTVDKFGRKPLQIiGALGMAIGMFSLgtaFY 358
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489055956 337 VATSSSVVGASILIMSFALLGTWGAL-YAFTPELYPTALRASGMGAAGA 384
Cdd:PRK10077 359 TQAPGIVALLSMLFYVAAFAMSWGPVcWVLLSEIFPNAIRGKALAIAVA 407
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-193 |
1.05e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 66.04 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 125 TLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIVTAAPALIGIWL 193
Cdd:cd17321 101 IMPASLALIAATFPGERRGRALGLWGAVVGIGAALgPLLGGLLLELFG----WRWIFLINVPIGLVALLL 166
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-424 |
2.67e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.54 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 142 RGRWLVMlegFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPEspmhllksgrveeakavinlvl 221
Cdd:cd17489 118 RGEGIGY---YGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD---------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 222 sRNGKPELPPGAKLLAPRLVTNERLLSPNLrqrtltslaIWFLVSVSYYGIFTWIPAKLASDGF---GFvrgygFLVVVA 298
Cdd:cd17489 173 -PPPVAAEEAEAGTRAFRRLVEKKVLPPAL---------ILFLASIAYGAISTFLPLYAAERGIsnaGL-----FFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 299 LAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATS--SSVVGASILIMSFALLGTwgALYAFTPELYPTALRA 376
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSpwMLLLAAVLYGLGFGLLFP--ALQALAVDLVPPHRRG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489055956 377 SGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAF 424
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
45-201 |
4.39e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.18 E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:cd17328 24 DIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEAS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 125 TLPVDYAMMAEFLPAKNRGRWLvmleGFWAVGTVVIAIAA--WATSVAGVEDAWRYIFIVTAAP-ALIGIWLRFRVPESP 201
Cdd:cd17328 104 YSPIAPTIIADLFPKEKRTRAL----GVFYFAIPLGSGLGyvVGGLVAQATGGWRWAFRVTGVLgVLLAILLLLFVREPP 179
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
52-431 |
4.55e-11 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 64.19 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 52 LTVPQALQTGTlFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFA-PDFGSLLALRFLTGLAVGGTLPVDY 130
Cdd:cd17356 43 SSSRQGLIVSI-VNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 131 AMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLlksgrv 210
Cdd:cd17356 122 VYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL------ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 211 eeakavinlvlsrngkpelppgakllaprlvtnerllspnlrQRTLTSLAIWFLVSVS------YYGifTWIPAKLASDG 284
Cdd:cd17356 196 ------------------------------------------YRTILGIMLQLFQQLTginyffYYG--TTIFQSTGLTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 285 FGFVRGYGFLVVVALAQLPGyalAAYGVEAWGRRKTLIGFLFVsaAACALFTVA--------------TSSSVVGASILI 350
Cdd:cd17356 232 SSPLLTSIILYIVNFVSTIP---GLFFVDKFGRRTCLLIGAAG--MSICLFIYAavgvrylipnpqsgTSNKSAGNGMIV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 351 MSFALLG----TWGAL-YAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFF 425
Cdd:cd17356 307 FICLFIFsfatTWGPIaWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAGCNLLAFIVVFF 386
|
....*.
gi 489055956 426 INVETR 431
Cdd:cd17356 387 FVPETK 392
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
60-431 |
6.53e-11 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 63.79 E-value: 6.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILL---ITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEF 136
Cdd:cd17432 55 TVSIFPLGGLFGSLLVGPLVIRLGRKGTLLlnnIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 137 LPAKNRGRWLVMLEGFWAVGtVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVEEA--K 214
Cdd:cd17432 135 APKNLRGAVGLVPAIFITLG-ILLGQVLGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAarK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 215 AVINLVLSRNGKPELPpgAKLLAPRLVTNERLLSPN--LRQRTLTslaiWFLVSVsyygIFTWIPAKLAsdGFGFVRGYG 292
Cdd:cd17432 214 ALQRLRGKEDVDDEME--EMLEEQRAEKGVGTVSVLelFRDRSVR----WQLISI----IVLMAGQQLC--GINAIYFYA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 293 FLVV----VALAQLPgYALAAYG-------------VEAWGRRKTLIGFLFVSAAACALFTVA-----TSS-----SVVG 345
Cdd:cd17432 282 DSIFleagIPEDKIQ-YVTVGTGacevlatitcvlvIERLGRRPLLIGGFGLMAVWCAVLTVAlslqnTVSwmpylSIVC 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 346 ASILIMSFAlLGTWGALYAFTPELYPTALRASGMGAAGAMARLG----GLLAPSAMAVVINQSFytavAMFAGLLALAGI 421
Cdd:cd17432 361 IFAYIASFG-IGPAGVPFILTTEIFDQSSRPAAFMVAGSLNWLSnflvGLLFPFIQEGLGAYCF----LVFAVICLLTAI 435
|
410
....*....|
gi 489055956 422 IAFFINVETR 431
Cdd:cd17432 436 YIFFVLPETK 445
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
47-426 |
1.28e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.60 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 47 AKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLaVGGTL 126
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL-TGGNV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 127 PVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGVEdawrYIFIVTAAPALIGIWLRFRVPespmhll 205
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILgPALGGFLSTPYGYA----LPFLVAAALALLNLVLVLFFL------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 206 ksgrveeakavinlvlsrngkpelppgakllaprlvtnerllsPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGF 285
Cdd:cd17330 174 -------------------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 286 GFvrGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAF 365
Cdd:cd17330 211 QI--GLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489055956 366 TPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
46-185 |
7.38e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 60.28 E-value: 7.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489055956 126 LPVDYAMMAEFLPAKNRGRWLvmleGFWAVGTVV-IAIAAWATSVAGVEDAWRYIFIVTAA 185
Cdd:cd17323 105 LAIGAGTIADLFTPEERGKAM----GVYSLGPLLgPALGPIIGGFITQSLGWRWIFWFLAI 161
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
44-197 |
1.07e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 59.70 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 44 AAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVG 123
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 124 GTLPVDYAMMAEFLPAKNRGRWlvmlegFWAVGTVVIAIAAWATSVAGVED---AWRYIFIVTAAPALIGIWLRFRV 197
Cdd:TIGR00710 109 AGSVISQALVRDIYPGEELSRI------YSILMPVLALAPAVAPLLGGYILvwlSWHAIFAFLSLAGILLSALIFFI 179
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
46-200 |
1.15e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 60.10 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:PRK03893 46 VQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGE 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489055956 126 LPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVViaiAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPES 200
Cdd:PRK03893 126 YGSSATYVIESWPKHLRNKASGFLISGFSIGAVV---AAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEA 197
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
45-193 |
3.91e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.97 E-value: 3.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGG 124
Cdd:cd17503 21 TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGV 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489055956 125 TLPVDYAMMAEFLPAKNRGrwlvMLEGFWAVGTVVI-----AIAAWATSVAGvedaWRYIFIVTAAPALIGIWL 193
Cdd:cd17503 101 LIPLAQTILLRIYPPEKRG----AAMGLVGLVILLApaigpTLGGWLTDNLS----WRWIFYINLPIGILALLL 166
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
69-201 |
1.70e-08 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 56.26 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 69 LVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVM 148
Cdd:cd17437 46 LVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSF 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489055956 149 LEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESP 201
Cdd:cd17437 126 PEIFINIGILLGYVSNYAFSGLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESP 178
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
46-401 |
1.70e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 56.23 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 126 LPVDYAMMAEFLPAKNRGRWLvmleGFWAVGTVV--IAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMH 203
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWV----SFWNCSHNVggGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 204 LLKSGRVEEAkavinlvlsrngKPELPPGAKLLAPRLVTNERLLSpnlrQRTLTSLAIW------FLVSVSYYGIFTWIP 277
Cdd:TIGR00881 177 SCGLPPAEEM------------PNEEPDGDAEKKEEELTKKQIFL----QYVLLNKVLWyislgyVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 278 AKLA-SDGFGFVRGYGFLVVVALAQLPGYALAAYGVEA-WGRRKTLIGFLFVSAAACAL--FTVATSSSVVGASILIMSF 353
Cdd:TIGR00881 241 LYLTqEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLlvYWLNPAANPLMDLICLFAL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489055956 354 ALLG-----TWGALyafTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVI 401
Cdd:TIGR00881 321 GFLVygpqmLIGVI---ASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLA 370
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
40-194 |
2.10e-08 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 55.83 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 40 GFTGAAIAKTFGLTVPQALQTGTLF------FLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--- 110
Cdd:cd17366 19 GYLAVTIGKVFFPGGDPTAQLLATFatfavaFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigv 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 111 -----LLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRG---RWLVM--LEGFwAVGTVVIAIAAWATSVAGVED-AWRYI 179
Cdd:cd17366 99 wapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGflgSWLEFgtLAGF-ILGAGLVTLLTLLLTEAQMLDwGWRIP 177
|
170
....*....|....*
gi 489055956 180 FIVTAAPALIGIWLR 194
Cdd:cd17366 178 FLIAAPLGLVGLYLR 192
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
56-425 |
2.29e-08 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 55.72 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 56 QALQTGT-LFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMA 134
Cdd:cd17361 51 QLLQLFTsSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 135 EFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGvEDAWRYIFIVTAAPALIGIWLRFRVPESPMhllksgrveeak 214
Cdd:cd17361 131 EMAPAKLRGALNIGFQLAITIGILIANLINYGTSKIK-PNGWRLSLGLAAVPALILLLGSLFLPETPN------------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 215 avinlvlsrngkpelppgakllAPRLVTNerLLSPNLRQRTLTSLAIWflvsvsyygiftWIPAKLASDGFGFVRGYGFL 294
Cdd:cd17361 198 ----------------------SPQLVIA--ILIPFFQQLTGINVIMF------------YAPVLFQTLGFGSDASLISA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 295 VVVALAQLPGYALAAYGVEAWGRRKTLIG-------FLFVSAAACALFTVATS------SSVVGASILIMSFALLGTWGA 361
Cdd:cd17361 242 VITGAVNVVSTLVSIYLVDRFGRRFLLLEggvqmlaSQVAIGILLAVKFGDGGelpkayAIAVVVLICLYVAAFAWSWGP 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489055956 362 LYAFTP-ELYPTALRASGMGAAGAMARLGGLlapsamavVINQSFYTAVA--------MFAGLLALAGIIAFF 425
Cdd:cd17361 322 LGWLVPsEIFPLETRSAGQSLTVAVNFLFTF--------VIAQAFLSMLCamkfgiflFFAGWVVVMSLFVYF 386
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-217 |
4.36e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.63 E-value: 4.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 33 AMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLL 112
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 113 ALRFLTGLAVGGTLPVDYAMMAEFLPaKNRGRWLVMLEGFWAVG-TVVIAIAAWATSVAGVedaWRYIFIVTAAPALIG- 190
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGaLIGPLIATSLLTSELS---WSWAYLIIGLIYLLLa 164
|
170 180
....*....|....*....|....*...
gi 489055956 191 -IWLRFRVPESPMHLLKSGRVEEAKAVI 217
Cdd:cd17333 165 iLILLTLFPELPSARNPQQSVGAFSASA 192
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
52-205 |
5.81e-08 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 54.42 E-value: 5.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 52 LTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYA 131
Cdd:cd17435 33 LSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCV 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489055956 132 MMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWAtsVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLL 205
Cdd:cd17435 113 YIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYA--FANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLV 184
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
50-203 |
8.34e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.12 E-value: 8.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 50 FGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDAL-FGLLSAFAPDFGSLLALRFLTGLAVGGTLPV 128
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALgLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489055956 129 DYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIA-IAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMH 203
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPlLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
32-199 |
1.03e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 53.62 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 32 DAMQVLaVGFTGAAIAKTFGLTvpqALQTGTLFFLGMLV---GAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDF 108
Cdd:COG2270 252 DGVQTV-IAFAGIYAAGVLGFS---TTELIVFGLLVQIVaalGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTA 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 109 GSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLvmleGFWAV--------GTVVIAIAAWATsvagveDAWRYIF 180
Cdd:COG2270 328 LAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFF----GLYALsgkaasflGPLLFGLVTQLT------GSQRLGI 397
|
170
....*....|....*....
gi 489055956 181 IVTAAPALIGIWLRFRVPE 199
Cdd:COG2270 398 LSLIVFFVIGLVLLLRVKV 416
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
46-200 |
1.26e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 53.38 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:PRK11102 17 IAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 126 LPVDYAMMAEFLPAKNRGRWLVMLegfwavgTVVIAIAAWATSVAG----VEDAWRYIFIVTAAPALIGIWL-RFRVPES 200
Cdd:PRK11102 97 SVVINALMRDMFPKEEFSRMMSFV-------TLVMTIAPLLAPIIGgwllVWFSWHAIFWVLALAAILAAALvFFFIPET 169
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
61-159 |
1.52e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 52.95 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 61 GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17502 36 GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115
|
90
....*....|....*....
gi 489055956 141 NRGRWLVMLEGFWAVGTVV 159
Cdd:cd17502 116 ERGKYQGYIGAVFGIASVA 134
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
59-195 |
1.69e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.04 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 59 QTGTLFFLGMLVGAALF---------GRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVD 129
Cdd:cd17391 235 ASNLAFISGLVFSATGVssllsaprlGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAI 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 130 YAMMAEFLPAKNRGRWLVMLEGFWAVGTVviaIAAWATSVAGVEDAWRYIFIVTAAPALIG-IWLRF 195
Cdd:cd17391 315 NSLLAKITPKEVAGRIFGYNQSFQYLGNV---AGPLLGSAIAAHFGYRAVFVVTALLVLLNaIWSFI 378
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
66-201 |
1.79e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 53.13 E-value: 1.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 66 LGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRW 145
Cdd:cd17362 50 LGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLL 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 146 LVMLEGFWAVGTVVIAIAAWAtsVAGVEDAWRYIFIVTAAPALI---GIWlrfRVPESP 201
Cdd:cd17362 130 VSLKELFIVLGILLGYVSGYA--FADVVGGWRYMYGLAAPPALLlgiGMW---FLPPSP 183
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
62-189 |
2.12e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.96 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 489055956 142 RGRWLVMLEGFWAVGTVViaiAAWATSVAGVEDAWRYIFIVTAAPALI 189
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLL---GPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
51-200 |
3.32e-07 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 52.12 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 51 GLTVPQALQTGTLFFLGML---VGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--------LLALRFLTG 119
Cdd:PRK10406 56 GNTTTQLLQTAGVFAAGFLmrpIGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 120 LAVGGTLPVDYAMMAEFLPAKNRG-----RWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLR 194
Cdd:PRK10406 136 LSVGGEYGTSATYMSEVAVEGRKGfyasfQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLR 215
|
....*.
gi 489055956 195 FRVPES 200
Cdd:PRK10406 216 RQLDET 221
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
63-186 |
4.38e-07 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 51.70 E-value: 4.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR 142
Cdd:cd17445 44 CFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 489055956 143 GRwLVMLEGFWAVGTVVIAIAawatsVAGVEDAWRYIFIVTAAP 186
Cdd:cd17445 124 LL-VAMAGGLTMVGGHFLLLG-----LALGCGSWRVLQGTITAP 161
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
64-197 |
7.33e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 51.08 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFG--SLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAKWAPPLE 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 142 RGRWLVMLEGFWAVGTVV-IAIAAWATSVAGvedaWRYIFIVTAAPALIGIWLRFRV 197
Cdd:cd17318 145 RSRLTSIAYSGSQFGTVIaMPLSGFLCESLG----WPSIFYIFGGLGLLWCLLWFFL 197
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
60-202 |
7.54e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.10 E-value: 7.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:cd17327 46 GNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKR 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489055956 140 KNRGRWLVMLEGFWAVGTVVIAIAAWA----TSVAGVEDaWRYIFIVTAAPALI-GIWLRFRVPESPM 202
Cdd:cd17327 126 EEQAKRIAFFYAAAGLGSIFGGLLAYGvfkiLGVGGLAG-WRWLFIIEGLITIIiGLVIFFWLPDNPS 192
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
64-212 |
1.01e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 50.90 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLL--ALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALvvFCRVIQGLAQGSVSPATHKIIVKWAPPKE 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 142 RGRWLVMLEGFWAVGT-VVIAIAAWATSVAGVEDAWRYIFIVTAAPALIgIWLRFRVPESPMHLLKSGRVEE 212
Cdd:TIGR00894 165 RSRLLGMSTSGFQLGTfIFLPISGWLCESWGGWPMIFYVFGIVGCAWSL-LWFVFPADDPSIHPCISKFEKK 235
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
40-386 |
1.88e-06 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 49.68 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 40 GFTGAAIAKTF---GLTVPQALQTGTLFFLGML---VGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--- 110
Cdd:cd17368 19 GFFAVYIGRLFfpsGSEFASLLLTFATFGVGFFmrpIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigi 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 111 -----LLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRG---RWLVMLEGFWAVGTVVIA--IAAWATSVAGVEDAWRYIF 180
Cdd:cd17368 99 aapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGfytSWQSASQQVAIVAGALVGylLSLTLTAEALAEWGWRIPF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 181 IVTAAPALIGIWLRFRVPESPmhllkSGRVEEAKAVINLVLSRNGKPElppgakllapRLVTNERLLspnlrqrtLTSLA 260
Cdd:cd17368 179 FIGLLIIPLGLWLRRSLEETE-----AFLERKARPTRRELFALLANNR----------RIILLGMLL--------VAGST 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 261 IWFLVSVSYYGIFtwipaklASDGFGFVRGYGFLV--VVALAQLPGYALAAYGVEAWGRRKTLI----GFLFVSAAACAL 334
Cdd:cd17368 236 VTFYFTTVYTPTY-------AKTVLGLSARDSFLVtlLAGVANFIWAPLGGALSDRIGRRPVLLvitlAALVTLYPVFAW 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489055956 335 FTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMA 386
Cdd:cd17368 309 LTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALA 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-426 |
2.34e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 61 GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17477 37 ASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 141 NRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEdawryIFIVTAAPALIGIWLrfrvpespmhllksgrveeakavinLV 220
Cdd:cd17477 117 NRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-----PFLIAAVLLLLALVP-------------------------LL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 221 LSRNGKPELPPGAKLLAPRLVTnerlLSPnlrqrtlTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALA 300
Cdd:cd17477 167 LTRRAAPEIEEAESISLRRLLR----IAP-------LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 301 QLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVgasILIMSFALLGTWGALY----AFTPELYPTALRA 376
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLA---LLVLLFLWGGAAGPLYtlalALAGDRLPGDELV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489055956 377 SGMGAAGAMARLGGLLAPSAMAVVINqsFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGALMD--AFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
25-139 |
2.74e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 25 FGLVWAADAMQVLAVGFTGAA----IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGL 100
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALllyyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 489055956 101 LSAFAP--DFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPA 139
Cdd:COG2211 310 LLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-425 |
3.33e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 74 LFGRLADKYGRR-RILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMLEGF 152
Cdd:cd17370 53 FSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 153 WAVGTVV-IAIAAWAtsVAGVEDAWRYIFIVTAAPALIGIWLRFRVpespmhllksgrveeakavinlvlsrngKPELPP 231
Cdd:cd17370 133 DTLGAVLgPLLAALL--LYLLGGNYRTIFLLAAIPALLALLILLFV----------------------------VKEYPR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 232 GAKLLAPRLVTNERLLSPNLRqrtlTSLAIWFLVSVSYYG-IFTWIPAKLASDGFGFVRGY--GFLVVVALAQLPGYALA 308
Cdd:cd17370 183 PPKLRKKSKKTSLKKLPKAFW----LYLLAVALFALGNFSfAFLILRAQELGLSAALIPLLyaLFNLVYALAAYPAGRLS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 309 aygvEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARL 388
Cdd:cd17370 259 ----DRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGI 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 489055956 389 GGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFF 425
Cdd:cd17370 335 GWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-195 |
4.42e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.32 E-value: 4.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPD--FGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17380 43 FFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYssLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSE 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 489055956 142 RGRWLVMLEGFWAVGTVViaiAAWATSVAGVEDAWRYIFIVTAAPALI--GIWLRF 195
Cdd:cd17380 123 RSRAVSIVTAGSYLGTLL---GGLIGPLLLEYYGWPSVFYFFGLLGLLwaLVWLIY 175
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
64-159 |
5.21e-06 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 48.24 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS--LLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17381 74 FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASWAPPLE 153
|
90
....*....|....*...
gi 489055956 142 RGRWLVMLEGFWAVGTVV 159
Cdd:cd17381 154 RSRLLTISYAGAQLGTVV 171
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
263-432 |
5.63e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 263 FLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVV-ALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSS 341
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLfSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 342 SVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGI 421
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
170
....*....|.
gi 489055956 422 IAFFINVETRQ 432
Cdd:pfam07690 166 VLLLLPRPPPE 176
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
62-158 |
5.88e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 48.02 E-value: 5.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLaVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd17388 45 ALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQ 123
|
90
....*....|....*..
gi 489055956 142 RGRWLVMLEGFWAVGTV 158
Cdd:cd17388 124 RARNFGLLGAAFGLGFI 140
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
61-425 |
7.12e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.04 E-value: 7.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 61 GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17312 44 GSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 141 NRGRWLVMLEGFWAVGTVVIAIAawATSVAGVEDaWRYIFIVTAAPALIG-IWLRFRVPESPMHLLksgrveeakavinl 219
Cdd:cd17312 124 ERGTVYGIWSTSHNFGGILAPIL--AASLASYYG-WRAAFLVPGIVGLVVaIILFFFLRDSPPYVW-------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 vlsrngkpelppgakllaprlvtnerllspnlrqrtLTSLAIWFLVSVSyYGIFTWIPAKL-ASDGFGFVRGYGFLVVVA 298
Cdd:cd17312 187 ------------------------------------VLSLAYAFVYIVR-YACLDWGPLYLyEVKGYSLIDAGWFSSLYE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 299 LAQLPGYALAAYGVEAWGRRKTLIGFLFVSAA---ACALFTVATSSSVVGASILIM-------SFALLGTWGALYAFTPE 368
Cdd:cd17312 230 VGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLmtlSLALFWFFPHNKLLSIVLLFLigffvggPINLIGGAAAQDIGRKE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 369 LYPTALrasgmGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFF 425
Cdd:cd17312 310 AAGTAT-----GFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLL 361
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
19-192 |
7.13e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 7.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 19 RGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALF 98
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 99 GLLSAFAPDFGS--LLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLVMlegFWAVGTVVIAIAAWATSVA----GV 172
Cdd:cd17316 257 ALPLFYLLSGSPtlLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL---SYNLGRLGGGGAPPLIALLlastGG 333
|
170 180
....*....|....*....|
gi 489055956 173 EDAWRYIFIVTAAPALIGIW 192
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
24-202 |
7.92e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 48.01 E-value: 7.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 24 IFGLVWAADAMQVLAVGFTGAAIAKTFGlTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSA 103
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 104 FAPDFGSLLALRFLTGLAvGGTLPVDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEdAWR---YIF 180
Cdd:cd06179 81 TAKSVNMLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAA-GWRwifYIN 158
|
170 180
....*....|....*....|..
gi 489055956 181 IVTAAPALIGIWLRFRVPESPM 202
Cdd:cd06179 159 AIFNALALILLFFFYHPPPRPQ 180
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
63-189 |
1.21e-05 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 47.13 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR 142
Cdd:cd17373 33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR 112
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 489055956 143 GRWLVMLEGFWAVGTVVIAiaawatSVAGVEDAWRYIFIVTAAPALI 189
Cdd:cd17373 113 LMITMVASLVAVAGQFLMP------GLAALCRDWRVLQALIICPFLL 153
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
63-217 |
1.51e-05 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 46.95 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 63 LFFLGMLVGAALFGRLADKYGRRRILLI----TVACDALFGLlSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLP 138
Cdd:cd17431 58 IFSVGGMIGSFSVGLFVNRFGRRNSMLYnnllAFAGAALMGL-SKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 139 AKNRGrwlvMLEGFWAVGTVV---IAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLL-KSGRVEEAK 214
Cdd:cd17431 137 TALRG----ALGTLHQLGIVVgilISQIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLiNRNEEEEAK 212
|
...
gi 489055956 215 AVI 217
Cdd:cd17431 213 SVL 215
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
29-192 |
1.55e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 47.35 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 29 WAADAMQVLAVGFTGAAIAKTfgltVPQALQT----------GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALF 98
Cdd:pfam06609 46 FAAFSLNVCATYFVLQASASA----LPNILQDigqsenqglfSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 99 GLLSAFAPDFGSLLALRFLTGLAVG--GTLPVdyaMMAEFLPAKNRgrwlvmlegfwAVGTVVIAIAAWATSVAG----- 171
Cdd:pfam06609 122 AIVGCTANKFNTLLAAMTLLGVAAGpaGASPL---FIGELMSNKTK-----------FLGLLIVSAPTIAMNGAGpyfgq 187
|
170 180
....*....|....*....|....*....
gi 489055956 172 ---VEDAWR---YIFIVTAAPA--LIGIW 192
Cdd:pfam06609 188 rlaIQGNWRwifYIYIIMSAIAvlLIIIW 216
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-426 |
3.18e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLT-GLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 141 NRGRWL-VMLEGFWAVGTVVIAIAAWATSVAGvedaWRYIFIVTAAPALIGIWLrfrvpespmhllksgrveeakavinL 219
Cdd:cd17355 125 RRGLALgILTAGGGLGSLVFLPLGAALIEAFG----WRTALLVLALLALLVLVP-------------------------V 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 220 VLSRNGKPELPPGAKLLAPRLVTNERLLSPNLRQRTLTSLAI-WFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVA 298
Cdd:cd17355 176 LLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALaFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 299 LAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSS-VVGASILIMSFALLGTWGALYAFTPELYPTALRAS 377
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPlALLLFAALFGLGWGATVPLTAALAARYFGARSYGT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 489055956 378 GMGAAGAMARLGGLLAPSAMAVVINQSFY--TAVAMFAGLLALAGIIAFFI 426
Cdd:cd17355 336 LFGLVFAPHQLGSALGPWLGGLLYDRTGSytAAWALAVALGLIAALLVLPI 386
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
52-435 |
3.55e-05 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 45.64 E-value: 3.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 52 LTVPQALQTGTLFFLGMLVGAALFGRLADKYGRR-RILLITVACDALFGLLSAfAPDFGSLLALRFLTGLAVGGTLPVDY 130
Cdd:cd17433 38 LDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKlSLMLCSVPFIAGFTVITA-AQNVWMLYVGRLLTGLASGVTSLVVP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 131 AMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSvagvedaWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRV 210
Cdd:cd17433 117 VYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD-------WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 211 EEAKAVINLVLSRNGKPELPPGakllapRLVTNERLLSPNLRQRTLTSLAIW--FLVSVS--YYGIFTWIPAKL--ASDG 284
Cdd:cd17433 190 QEAMAALRFLRGPDQGWEWECI------GIEQSFHLEEQSFSLALLKQPGIYkpLIIGVSlmAFQQLTGINAVMfyAETI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 285 F---GFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIgflfVSAAACALFTVATSSSVVGA-SILIMSFALlgTWG 360
Cdd:cd17433 264 FeeaKFKDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLV----LSGVVMVFSTAAFGWLAVGSmGFFIAGFAV--GWG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 361 AL-YAFTPELYPTALRASGMGAAgamarlggLLAPSAMAVVINQSF---------YTAVAMFAGLLALAGIIAFFINVET 430
Cdd:cd17433 338 PIpWLVMSEIFPLHVRGVASGIC--------VLTNWLMAFLVTKEFsslmevlssYGTFWLFSAFCAFSVLFTLFCVPET 409
|
....*
gi 489055956 431 RQQAL 435
Cdd:cd17433 410 KGKTL 414
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
62-140 |
4.14e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.62 E-value: 4.14e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALrFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17478 237 SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGN 314
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
248-428 |
4.93e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 248 SPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFV 327
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 328 SAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYT 407
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|.
gi 489055956 408 AVAMFAGLLALAGIIAFFINV 428
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
61-193 |
6.48e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 44.96 E-value: 6.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 61 GTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAvGGTLPVDYAMMAEFLPAK 140
Cdd:cd17389 70 GSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGIS-KGNVSLSTAIVADVTSPK 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489055956 141 NRGRWLVMLEGFWAVG-TVVIAIAAWATSVAGVEDAWRYIfivtaAPALIGIWL 193
Cdd:cd17389 149 KRSKGMALIGVAFSLGfIIGPMIGAYFASFTRSLGEVFFS-----MPALFALVL 197
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-188 |
6.59e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 51 GLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFG-SLLALRFLTGLAVGGTLPVD 129
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPlALLVLLFLWGGAAGPLYTLA 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 130 YAMMAEFLPAKNRGRWLVMLEGFWAVGTVV-IAIAAWATSVAGVEDAWRYIFIVTAAPAL 188
Cdd:cd17477 299 LALAGDRLPGDELVAANAALLLLYGLGSVIgPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
65-201 |
7.36e-05 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 44.72 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 65 FLGMLVGAALFGRLADKYGRRRILLITV----ACDALFGLLSAF------APDFgsLLALRFLTGLAVGGTLPVDYAMMA 134
Cdd:PRK09952 74 FLFRPLGGVVFGHFGDRLGRKRMLMLTVwmmgIATALIGLLPSFstigwwAPVL--LVTLRAIQGFAVGGEWGGAALLAV 151
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 135 EFLPAKNRGRWLVMLEGFWAVGTV-----VIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESP 201
Cdd:PRK09952 152 ESAPKNKKAFYSSGVQVGYGVGLLlstglVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESA 223
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
62-172 |
7.78e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330
|
90 100 110
....*....|....*....|....*....|....*
gi 489055956 142 RGR----WLVMLEGFWAVGTVVIAIAAWATSVAGV 172
Cdd:cd06173 331 RGRvfsvYNALNSGAMPLGALLAGLLADALGLSAV 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
30-143 |
9.56e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.54 E-value: 9.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 30 AADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFG 109
Cdd:cd17475 6 AAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP 85
|
90 100 110
....*....|....*....|....*....|....
gi 489055956 110 SLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRG 143
Cdd:cd17475 86 VLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERG 119
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-425 |
9.75e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 9.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 126 LPVDYAMMAEFLPaKNRGRWLvmleGFWAV-GTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHL 204
Cdd:cd17478 102 HPEGARLASQAAG-GRRGLAM----SIFSVgGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 205 LKSgrvEEAKAVINLVLSRNGKPELPpgakllaprlvtnerllspnlrqrtLTSLAiwFLVSVSYYGIFTWIPAKLASDG 284
Cdd:cd17478 177 AKK---AAAKSSARSTLKGVWRALLL-------------------------LLIIV--FLRSWVLSSLTTFLPFYLVQRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 285 FGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVaTSSSVVGASILIMSFALLGTWGALYA 364
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489055956 365 FTPELYPTALR-ASGM------GAAGAMARLGGLLApsamavviNQSFYTAVAMFAGLLALAGIIAFF 425
Cdd:cd17478 306 LAQELLPGNVGlASGLmmglsfGLGGIGAPVLGALA--------DAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-426 |
1.03e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 60 TGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGS-----LLALRFLTGLAVGGTLPVDYAMMA 134
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwlLLVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 135 EFLPAKNRGRWLVMLEGFWAVGTVVI-AIAAWATSVAGVEdawrYIFIVTAAPALIGIWLRFRVPespmhllksgrveea 213
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGpALGGLLVALLGPG----GAFAINALSFLLSALLLLFIR--------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 214 kavINLVLSRNGKPELPPGAKLLAPRLVTNERLLSpnlrqRTLTSLAIWFLVSVSYYGIFtwipAKLASDGFGF-VRGYG 292
Cdd:cd06173 180 ---RPPPAAPGESSSLLLRDLREGLRYLRRSPLLR-----LLLLALALFALLGGALTVLL----PLLAKEVLGGgAAGYG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 293 FLV-VVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYP 371
Cdd:cd06173 248 LLLaAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489055956 372 TALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd06173 328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC22A23 |
cd17444 |
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ... |
64-142 |
1.62e-04 |
|
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341002 [Multi-domain] Cd Length: 364 Bit Score: 43.68 E-value: 1.62e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR 142
Cdd:cd17444 45 LLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHR 123
|
|
| MFS_SLC22A31 |
cd17443 |
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ... |
64-155 |
2.26e-04 |
|
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 43.23 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 64 FFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRg 143
Cdd:cd17443 45 YLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHR- 123
|
90
....*....|..
gi 489055956 144 RWLVMLEGFWAV 155
Cdd:cd17443 124 LMVSMGAGFFSV 135
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-423 |
2.43e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 57 ALQTGTLFFLGMLVGAA---LFGRLAD----KYGRRR-ILLITVACDALFGLLSAFAPDFGS------LLALRFLTGLAV 122
Cdd:COG2211 45 AALVGLILLVARLWDAItdpLIGALSDrtrtRWGRRRpWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 123 GGTLPVDYAMMAEFLP-AKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDA---WRYIFIVTAAPALIG-IWLRFRV 197
Cdd:COG2211 125 TLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgYRLTALIFAVLGLLAfLLTFFGT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 198 PESPmhllksgrveeakavinlvLSRNGKPELPPGAKLLaprlvtnerllspnLRQRTLTSLAIWFLVSVSYYGIFTWIP 277
Cdd:COG2211 205 KERP-------------------VPEEEKVSLKESLKAL--------------LKNRPFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 278 AKLASDGFGFVRGYG--FLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVG--ASILIMSF 353
Cdd:COG2211 252 LYYFKYVLGLSAALVglLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLllVLAALAGI 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 354 ALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVvinqsfytAVAMFAGLLALAGIIA 423
Cdd:COG2211 332 GLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQAL--------AGALAGLLLALFGYVA 393
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
19-191 |
2.78e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.90 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 19 RGLLGIFGLVWAADAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALF 98
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALF 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 99 GLLSAFAPDFGS----LLALRFLTGLAVGGTLPVDYAMMAEFLPAKNR--GRWLVMLEGFWAVGTVVIAIAAWATSVAGv 172
Cdd:cd17369 308 AFPFFWLLDTGStwliVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRytGASLGYQLGAILGGGFAPLIATALVAATG- 386
|
170
....*....|....*....
gi 489055956 173 edAWRYIFIVTAAPALIGI 191
Cdd:cd17369 387 --SWWPVALYLAALAVISL 403
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
58-207 |
2.90e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.97 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 58 LQTGTLFFLGMLVGA-----AL----FGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGL-AVGGtlp 127
Cdd:cd17472 26 LPGATPTLIGLALGIygltqAIfqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgAISS--- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 128 VDYAMMAEFLPAKNRGRWLVMLegfwavgTVVIAIAAWATSVAGVEDAWRY----IFIVTAAPALIGI-WLRFRVPESPM 202
Cdd:cd17472 103 VVMALLADLTREENRTKAMALI-------GASIGIAFAISMVLGPLLAAHLgvsgLFLITAILSLVSLlILLFFVPDPPK 175
|
....*
gi 489055956 203 HLLKS 207
Cdd:cd17472 176 IVQIS 180
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
54-135 |
3.04e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 43.00 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 54 VPQALqtgTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMM 133
Cdd:PRK15402 50 VPTSM---TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAI 126
|
..
gi 489055956 134 AE 135
Cdd:PRK15402 127 QE 128
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
52-213 |
4.74e-04 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 42.13 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 52 LTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYA 131
Cdd:cd17434 38 LNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 132 MMAEFLPAKNRGrwlvmleGFWAVGTVVIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSGRVE 211
Cdd:cd17434 118 YVSEISHPGVRG-------ALGACPQIMAVFGSLALYALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDE 190
|
..
gi 489055956 212 EA 213
Cdd:cd17434 191 KA 192
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
315-425 |
6.87e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.84 E-value: 6.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 315 WGRRKTLIGFLFVSAAACALFTVATS-SSVVGASILImSFALlGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLA 393
Cdd:cd06179 59 FGRRWFFIGGNLLGVVGSIVAGTAKSvNMLIGGQALI-GIGA-GTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALG 136
|
90 100 110
....*....|....*....|....*....|....*....
gi 489055956 394 PSAMAVVINQS-------FYTAVAMFAglLALAGIIAFF 425
Cdd:cd06179 137 PLIAGALVEANaagwrwiFYINAIFNA--LALILLFFFY 173
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
51-424 |
7.38e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.52 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 51 GLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDY 130
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 131 AMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGV--EDAWRYIFIVTAAPALIGIWLRFRVPESPMHLLKSG 208
Cdd:cd06180 110 NLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLswRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 209 RveeakavinlvlsrngkpelPPGAKLLAPRLvtnerllspnlrqrtltsLAIWFLVSVSYYGIFTWIPAKLASDGFGFV 288
Cdd:cd06180 190 S--------------------APGLNRPLWRL------------------ALAYGLFGFGYIITATFLPLIARETGAGSL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 289 RGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPE 368
Cdd:cd06180 232 LAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARE 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489055956 369 LYPTAlRASGMGAAGAMARLGGLLAPSAMAVVINQ--SFYTAVAMFAGLLALAGIIAF 424
Cdd:cd06180 312 LAPPA-APRALALMTASFGVGQILGPLLAGWLADAtgGFAPALILAAAALVVAALLAL 368
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-122 |
7.43e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 41.42 E-value: 7.43e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 44 AAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAV 122
Cdd:PRK11043 30 KAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV 108
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
73-134 |
7.88e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.48 E-value: 7.88e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 73 ALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMA 134
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLG 112
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
259-426 |
9.01e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 9.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 259 LAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVA 338
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 339 TSSSVVGASILIMSFALLGTWGALYAFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVINQSFYTAVAMFAGLLAL 418
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
....*...
gi 489055956 419 AGIIAFFI 426
Cdd:cd06174 162 ALLAAILL 169
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
46-185 |
1.78e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 40.46 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 46 IAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGT 125
Cdd:PRK10091 29 LAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPHGAF 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489055956 126 LPVDyAMMAEFLPAKNRGRWLV--MLEGFWAVGTVVIAIAAWatsvAGVEDAWRYIFIVTAA 185
Cdd:PRK10091 109 FGVG-AIVLSKIIKPGKVTAAVagMVSGMTVANLLGIPLGTY----LSQEFSWRYTFLLIAV 165
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
34-189 |
1.92e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 40.30 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 34 MQVLAVGFTGAA----IAKTFGLTVP-----QALQTGTLFFLGMLVGAA------LFGRLADKYGRRRI----LLITVAC 94
Cdd:cd17345 2 WQVFLGIFIGYAgyylVRNNFSLAQPylieqYGLSKTEIGLIGSALSIAyglskfVMGNLSDRSNPKRFlaigLILSAII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 95 DALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKNRGRWLvmleGFWAV-----GTVVIAIAAWATSV 169
Cdd:cd17345 82 NILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWT----SIWNIshnvgGGLVGPLAGLGLAI 157
|
170 180
....*....|....*....|
gi 489055956 170 AGVEDaWRYIFIVTAAPALI 189
Cdd:cd17345 158 FGDGW-WRGAFIFPAIIAII 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-140 |
2.13e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 20 GLLGIFGLVwaadAMQVLAVGFTGAAIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFG 99
Cdd:COG0738 215 GGLAIFLYV----GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 489055956 100 LLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:COG0738 291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR 331
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
51-423 |
2.43e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 40.05 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 51 GLTVPQALQTGTLFFLGMLVGA--ALFGRLADKYGRRRILLI-TVACDALFgLLSAFAPDFGSLLALRFLTGLAVGGTLP 127
Cdd:pfam06779 24 QFSLSQAGLLAAANYAGYLAGAllASFAWRHGASRLRPALLAgLLATVLLL-LAMAATSSFWAVLLIRFLAGVASAAVMI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 128 VDYAMMAEFLPAKNRGRWLVMLEGFWAVGTVVIAIAAWATSVAGVEDAWR-YIFIVTAAPALIGIWLRFRVPEspmhllk 206
Cdd:pfam06779 103 FGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLwYGAGVLSAVLTLAVFPLLPRRA------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 207 sgrveeakavinlvlSRNGKPELPPGAKLLAPRLvtnerllspnlrqrTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFG 286
Cdd:pfam06779 176 ---------------PRHASAPAPAAKPLQRSLP--------------LWILTLAYGLAGFGYIITATFLPAMARDGFGG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 287 FVRGYGFLVVVALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFT 366
Cdd:pfam06779 227 PAAAALFWSLFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLA 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 367 PELYPTALRASgMGAAGAMARLGGLLAPSAMAVVINQ--SFYTAVAMFAGLLALAGIIA 423
Cdd:pfam06779 307 RELAPPAPRRL-LGLMTASFGIGQILGPLLASLLTAAtgGLTPALLLAAAALVLAALIV 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
62-197 |
2.44e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGR-LADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAK 140
Cdd:cd17474 241 AGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489055956 141 NRGRWLVMLEGFWAVGtvvIAIAAWATSVAGVEDAWRYIFIVTAAPALIGIWLRFRV 197
Cdd:cd17474 321 ERGTASSLYNFVRFLG---QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
65-164 |
3.19e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 65 FLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLaVGGTLPVDYAMMAEFLPAKNRGr 144
Cdd:cd17391 46 FLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSG- 123
|
90 100
....*....|....*....|
gi 489055956 145 wlvmlegfWAVGTVVIAIAA 164
Cdd:cd17391 124 --------WALGTLSTGVVA 135
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
66-428 |
3.52e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 66 LGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTlpvDYAMMAEFLPAKNRGRW 145
Cdd:cd17393 45 VGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGAL---DVAMNAQGVAVERAYGR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 146 LVM--LEGFWAVGTVVIAIAAWATSVAGVEDAWRYIfivtaapaligiwlrfrvpespmhllksgrveeAKAVINLVLSR 223
Cdd:cd17393 122 PIMssLHAMWSLGGLAGALLGAAAIGAGVSPGVHLL---------------------------------AAAVLLLLAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 224 NGKPELPPGAKLLAPRLVTNERLLSPNLRQRTLTSLAIWFLVSVSYYGIFTWIPAKLASDGFGFVRGYGFL--VVVALAQ 301
Cdd:cd17393 169 VAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALgyAVFSLAM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 302 LPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVGASILIMSFALLGTWGALYAFTPELYPTAlRASGMGA 381
Cdd:cd17393 249 TVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA-AGIAVAR 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489055956 382 AGAMARLGGLLAPSAMAVVinQSFYTAVAMFAGLLALAGIIAFFINV 428
Cdd:cd17393 328 VATLGYLGFLVGPPLIGFL--ADATGLRTAFLVVALLALLVALLARA 372
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
62-151 |
3.64e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 39.23 E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 62 TLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTLPVDYAMMAEFLPAKN 141
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90
....*....|
gi 489055956 142 RGRWLVMLEG 151
Cdd:PRK10473 125 RAKVLSLLNG 134
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
36-143 |
4.11e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.48 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 36 VLAVGFTGAAIAKTFGLTVPQALQTgTLFFLGMLVGAALFGRLADKYGRRRILLIT----VACDALFGLLSAFAPDFGSL 111
Cdd:cd17358 256 INAVIFYASSIFDEAGSGLDPNTAT-IIIGVVQVVGTLVATLLVDRLGRRPLLLVSaigmGIGLLALGLYFYLQEHGALL 334
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489055956 112 LALRFLTGLAVG--------GTLPVDYAMMAEFLPAKNRG 143
Cdd:cd17358 335 SSVSWLPLVGLViyiisfsiGLGPLPWVIMSEIFPAKIKG 374
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
45-426 |
4.56e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 45 AIAKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSL-LALRFLTGLAVG 123
Cdd:cd17353 28 PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLfLGYGVLGGIGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 124 GTLPVDYAMMAEFLPAKnRGrwlvmlegfWAVGtvvIAIAAWATSVAGvedawrYIFIVTAAPALIGIWLRFrvpespmh 203
Cdd:cd17353 108 IGYITPVSTAVKWFPDK-RG---------LATG---IVIAGFGLGSLI------FSPLIAYLINTVGVPTTF-------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 204 lLKSGRVEEAKAVINLVLSRN-GKPELPPGAKLLAPRLVTNERLLSPN--LRQRTLTSLAIWFLVSVSYYGIFTWIPAKL 280
Cdd:cd17353 161 -LILGIIFLIIIVIGAFLIRDpPKGWVPPGVDPLANNAENSPRDYTPRemLRTPTFWLLWLMFFLNATAGLMLIGQAKPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 281 ASDGFGFVRGYGFLVV--VALAQLPGYALAAYGVEAWGRRKTLIGFLFVSAAACALFTVATSSSVVgasILIMSFALLGT 358
Cdd:cd17353 240 GQEFAGLDAGIAALAVsiLSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVL---FVLGVALIGFC 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489055956 359 WGALY----AFTPELYPTALRASGMGAAGAMARLGGLLAPSAMAVVIN-QSFYTAVAMFAGLLALAGIIAFFI 426
Cdd:cd17353 317 YGGGFalfpALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYtGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
69-159 |
4.88e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 38.75 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 69 LVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLaVGGTLPVDYAMMAEFLPAKNRGRWLVM 148
Cdd:cd17390 45 LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGR 123
|
90
....*....|.
gi 489055956 149 LEGFWAVGTVV 159
Cdd:cd17390 124 FNAASSLGFIL 134
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
47-191 |
6.77e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489055956 47 AKTFGLTVPQALQTGTLFFLGMLVGAALFGRLADKYGRRRILLITVACDALFGLLSAFAPDFGSLLALRFLTGLAVGGTL 126
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489055956 127 PVDYAMMAEFLPAKNRGR---WLVMLEG-FWAVGTVVIAIAAWATSvagvedaWRYIFIVTAAPALIGI 191
Cdd:cd17370 306 SIERAAVADLVPAELRGTaygLFNTVVGiGWLLASLIAGYLWDLIS-------PSAAFLFSAVLALIAL 367
|
|
| |
