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Conserved domains on  [gi|489056897|ref|WP_002967024|]
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MULTISPECIES: GMC family oxidoreductase [Brucella]

Protein Classification

GMC family oxidoreductase( domain architecture ID 11455227)

GMC (glucose-methanol-choline) family oxidoreductase is a flavoprotein that catalyzes the oxidation of an alcohol moiety to the corresponding aldehyde with the concomitant reduction of flavin adenine dinucleotide (FAD)

EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0050660
PubMed:  23578136|1542121
SCOP:  3000055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-528 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 724.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEAGGSDWNPLFHMPAGFAKMTKGVA-SWGWQTVPQKHMKNRVLRYTQA 79
Cdd:COG2303    3 EEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRyDWRYETEPQPGLNGRRLYWPRG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  80 KVIGGGSSINAQIYTRGNAADYDLWAdEEGCTGWGYRSVLPYFKRAEDNQRFNDDYHAYGGPLGVSMPSAPLPICDAYIR 159
Cdd:COG2303   83 KVLGGSSSINGMIYVRGQPEDFDLWA-QLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLPNPLSDAFIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 160 AGQELGIPYNPDFNGREQAGVGFYQLTQRNRRRSSASLAYLAPIRDRRNLTIRMNAQVATIVLEKTRATGVALMSG---E 236
Cdd:COG2303  162 AAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFDGGRATGVEYRDDgeeH 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 237 VLRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHLDLFVIAECTGDHTYdgvAKLHRTLAA 316
Cdd:COG2303  242 TVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTL---NKSLRKARI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 317 GLQYVLLRSGPVASSLFETGGFWYADPDARSPDIQFHLGLGSGIEA-GVEKLKNA-GVTLNSAYLHPRSRGTVRLASNDP 394
Cdd:COG2303  319 GLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPRwGKKALHDGhGFTAHVEQLRPESRGRVTLDSADP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 395 ALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMAERLPGPKVVTDDDLfDYACANAKTDHHPVGTCKMGGDA 474
Cdd:COG2303  399 LGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEEL-AFIRARAYTIYHPVGTCRMGTDP 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489056897 475 MAVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEKGADIIRGLDPLP 528
Cdd:COG2303  478 DSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGDYLKN 531
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-528 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 724.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEAGGSDWNPLFHMPAGFAKMTKGVA-SWGWQTVPQKHMKNRVLRYTQA 79
Cdd:COG2303    3 EEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRyDWRYETEPQPGLNGRRLYWPRG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  80 KVIGGGSSINAQIYTRGNAADYDLWAdEEGCTGWGYRSVLPYFKRAEDNQRFNDDYHAYGGPLGVSMPSAPLPICDAYIR 159
Cdd:COG2303   83 KVLGGSSSINGMIYVRGQPEDFDLWA-QLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLPNPLSDAFIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 160 AGQELGIPYNPDFNGREQAGVGFYQLTQRNRRRSSASLAYLAPIRDRRNLTIRMNAQVATIVLEKTRATGVALMSG---E 236
Cdd:COG2303  162 AAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFDGGRATGVEYRDDgeeH 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 237 VLRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHLDLFVIAECTGDHTYdgvAKLHRTLAA 316
Cdd:COG2303  242 TVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTL---NKSLRKARI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 317 GLQYVLLRSGPVASSLFETGGFWYADPDARSPDIQFHLGLGSGIEA-GVEKLKNA-GVTLNSAYLHPRSRGTVRLASNDP 394
Cdd:COG2303  319 GLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPRwGKKALHDGhGFTAHVEQLRPESRGRVTLDSADP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 395 ALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMAERLPGPKVVTDDDLfDYACANAKTDHHPVGTCKMGGDA 474
Cdd:COG2303  399 LGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEEL-AFIRARAYTIYHPVGTCRMGTDP 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489056897 475 MAVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEKGADIIRGLDPLP 528
Cdd:COG2303  478 DSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGDYLKN 531
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-529 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 628.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEAGGSD--WNPLFHMPAGFA---KMTKgvASWGWQTVPQKHMKNRVLR 75
Cdd:PRK02106   4 MEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAfplQGKR--YNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  76 YTQAKVIGGGSSINAQIYTRGNAADYDLWADEEGCTGWGYRSVLPYFKRAEDNQRFNDDYHAYGGPLGVSMPSAPL-PIC 154
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELPGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGTnPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 155 DAYIRAGQELGIPYNPDFNGREQAGVGFYQLTQRNRRRSSASLAYLAPIRDRRNLTIRMNAQVATIVLEKTRATGVALMS 234
Cdd:PRK02106 162 QAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFEGKRAVGVEYER 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 235 G---EVLRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHLDLFVIAECTGDHTYDGVAKLH 311
Cdd:PRK02106 242 GggrETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPVSLYPALKWW 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 312 RTLAAGLQYVLLRSGPVASSLFETGGFWYADPDARSPDIQFHLGLGSGIEAGVEKLKNAGVTLNSAYLHPRSRGTVRLAS 391
Cdd:PRK02106 322 NKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSPSRGSVKLKS 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 392 NDPALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMAERLPGPKVVTDDDLFDYACANAKTDHHPVGTCKMG 471
Cdd:PRK02106 402 ADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAYHPSCTCKMG 481

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489056897 472 GDAMAVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEKGADIIRGLDPLPP 529
Cdd:PRK02106 482 TDPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLAR 539
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 381-516 3.35e-48

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 163.72  E-value: 3.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  381 PRSRGTVRLASNDPALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMA-----ERLPGPKVVTDDDLFDYAC 455
Cdd:pfam05199   1 PRSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGLVLGVELtpgpvPEVSDAAVTSDDELLAYIR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489056897  456 ANAKTDHHPVGTCKMGGDAM-AVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEK 516
Cdd:pfam05199  81 AAASTSYHPMGTCRMGADPDdAVVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAER 142
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 3-33 5.38e-04

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 42.31  E-value: 5.38e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 489056897    3 YDYIIVGGGPAGCVLANRLSeDASIKVLLLE 33
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLA-DKGLRVLLLE 30
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-528 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 724.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEAGGSDWNPLFHMPAGFAKMTKGVA-SWGWQTVPQKHMKNRVLRYTQA 79
Cdd:COG2303    3 EEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRyDWRYETEPQPGLNGRRLYWPRG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  80 KVIGGGSSINAQIYTRGNAADYDLWAdEEGCTGWGYRSVLPYFKRAEDNQRFNDDYHAYGGPLGVSMPSAPLPICDAYIR 159
Cdd:COG2303   83 KVLGGSSSINGMIYVRGQPEDFDLWA-QLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLPNPLSDAFIE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 160 AGQELGIPYNPDFNGREQAGVGFYQLTQRNRRRSSASLAYLAPIRDRRNLTIRMNAQVATIVLEKTRATGVALMSG---E 236
Cdd:COG2303  162 AAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFDGGRATGVEYRDDgeeH 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 237 VLRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHLDLFVIAECTGDHTYdgvAKLHRTLAA 316
Cdd:COG2303  242 TVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTL---NKSLRKARI 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 317 GLQYVLLRSGPVASSLFETGGFWYADPDARSPDIQFHLGLGSGIEA-GVEKLKNA-GVTLNSAYLHPRSRGTVRLASNDP 394
Cdd:COG2303  319 GLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPRwGKKALHDGhGFTAHVEQLRPESRGRVTLDSADP 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 395 ALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMAERLPGPKVVTDDDLfDYACANAKTDHHPVGTCKMGGDA 474
Cdd:COG2303  399 LGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEEL-AFIRARAYTIYHPVGTCRMGTDP 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489056897 475 MAVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEKGADIIRGLDPLP 528
Cdd:COG2303  478 DSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGDYLKN 531
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-529 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 628.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEAGGSD--WNPLFHMPAGFA---KMTKgvASWGWQTVPQKHMKNRVLR 75
Cdd:PRK02106   4 MEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAfplQGKR--YNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  76 YTQAKVIGGGSSINAQIYTRGNAADYDLWADEEGCTGWGYRSVLPYFKRAEDNQRFNDDYHAYGGPLGVSMPSAPL-PIC 154
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELPGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGTnPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 155 DAYIRAGQELGIPYNPDFNGREQAGVGFYQLTQRNRRRSSASLAYLAPIRDRRNLTIRMNAQVATIVLEKTRATGVALMS 234
Cdd:PRK02106 162 QAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFEGKRAVGVEYER 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 235 G---EVLRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHLDLFVIAECTGDHTYDGVAKLH 311
Cdd:PRK02106 242 GggrETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPVSLYPALKWW 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 312 RTLAAGLQYVLLRSGPVASSLFETGGFWYADPDARSPDIQFHLGLGSGIEAGVEKLKNAGVTLNSAYLHPRSRGTVRLAS 391
Cdd:PRK02106 322 NKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSPSRGSVKLKS 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 392 NDPALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMAERLPGPKVVTDDDLFDYACANAKTDHHPVGTCKMG 471
Cdd:PRK02106 402 ADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAYHPSCTCKMG 481

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489056897 472 GDAMAVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEKGADIIRGLDPLPP 529
Cdd:PRK02106 482 TDPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLAR 539
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 381-516 3.35e-48

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 163.72  E-value: 3.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  381 PRSRGTVRLASNDPALPPLIDPNYWSDPHDRKMSLEGLKIAREIMQQDALKPYVMA-----ERLPGPKVVTDDDLFDYAC 455
Cdd:pfam05199   1 PRSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGLVLGVELtpgpvPEVSDAAVTSDDELLAYIR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489056897  456 ANAKTDHHPVGTCKMGGDAM-AVVDLDLKVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGEK 516
Cdd:pfam05199  81 AAASTSYHPMGTCRMGADPDdAVVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAER 142
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 3-291 3.02e-43

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 153.21  E-value: 3.02e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897    3 YDYIIVGGGPAGCVlaNrlsedasikvllleaggsdwNPLFHMPAGfakmtkgvaswgwqtvpqkhmknrvlrytqaKVI 82
Cdd:pfam00732   1 YDYLYEGGGSAGSV--N--------------------GRRMILPAG-------------------------------STV 27

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   83 GGGSSINAQIYTRGNAADYDLWADEEGCTGWGYRSVLPYFKRAEdnqrfnddyhaygGPLGVS-MPSAPLPICDAYIRAG 161
Cdd:pfam00732  28 GGGSSVNWSACIRTPAAVLDEWASEFGLEGWGYDDYLPYMDKVE-------------GPLGVTtKGIEESPLNQALLKAA 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  162 QELGIPYNP---DFNGREQAGVGFYQltQRNRRRSSASLAYLAPIRdRRNLTIRMNAQVATIVLE--KTRATGVALMSGE 236
Cdd:pfam00732  95 EELGYPVEAvprNSNGCHYCGFCGLG--CPTGAKQSTARTWLRPAL-ERNLRILTGAKAEKIIILgrGGRAVGVEARDGG 171

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  237 -----VLRASREVIVSSGAIGSPKLLLQSGIGPADHlkkvgiavkhdlpGVGENMQDHLD 291
Cdd:pfam00732 172 ggikrLITAAKEVVVAAGALNTPPLLLRSGLGKNPH-------------PVGKNLQLHPV 218
PLN02785 PLN02785
Protein HOTHEAD
 3-523 1.14e-35

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 140.71  E-value: 1.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   3 YDYIIVGGGPAGCVLANRLSEDasIKVLLLEAGGSDWNPL-------FHMpaGFAKMTKGVASWGWQTVpqkhmkNRVLR 75
Cdd:PLN02785  56 YDYIVVGGGTAGCPLAATLSQN--FSVLLLERGGVPFGNAnvsflenFHI--GLADTSPTSASQAFIST------DGVIN 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  76 yTQAKVIGGGSSINAQIYTRGNAAdydlWADEegcTGWGYRSVLPYFKRAEDNQrfnddyhayggplgVSMPS-APLpic 154
Cdd:PLN02785 126 -ARARVLGGGTCINAGFYSRASTR----FIQK---AGWDAKLVNESYPWVERQI--------------VHWPKvAPW--- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 155 DAYIRAG-QELGI-PYN----PDFNGREQAGVGFyqlTQRNRRRSSASLAYLApirDRRNLTIRMNAQVATIVLE----K 224
Cdd:PLN02785 181 QAALRDSlLEVGVsPFNgftyDHVYGTKVGGTIF---DEFGRRHTAAELLAAG---NPNKLRVLLHATVQKIVFDtsgkR 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 225 TRATGV-----------ALMSGevlRASREVIVSSGAIGSPKLLLQSGIGPADHLKKVGIAVKHDLPGVGENMQDHldlf 293
Cdd:PLN02785 255 PRATGVifkdengnqhqAFLSN---NKGSEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPVVLHNEHVGKGMADN---- 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 294 viaectgdhtydgvaklhrtlaaGLQYVLLRS-GPVASSLFET------GGFWYADPD-ARSPD-IQFHLGLGSgieAGV 364
Cdd:PLN02785 328 -----------------------PMNSIFVPSkAPVEQSLIQTvgitkmGVYIEASSGfGQSPDsIHCHHGIMS---AEI 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 365 EKL-----KNAGVTLNSAYLH---------------------PRSRGTVRLASNDPALPPLIDPNYWSDPHDRKMSLEGL 418
Cdd:PLN02785 382 GQLstippKQRTPEAIQAYIHrkknlpheafnggfilekiagPISTGHLSLINTNVDDNPSVTFNYFKHPQDLQRCVYGI 461

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897 419 KIAREIMQQDALKPYVMAERLPG---------------PKVVTDDDLFDYACANA-KTDHHPVGTCKMGgdamAVVDLDL 482
Cdd:PLN02785 462 RTIEKIVKTNHFTNFTQCDKQTMekvlnmsvkaninliPKHTNDTKSLEQFCKDTvITIWHYHGGCHVG----KVVDQNY 537

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 489056897 483 KVRGLEGLRVCDSSVMPRVPSCNTNAPTIMIGE-KGADIIRG 523
Cdd:PLN02785 538 KVLGVSRLRVIDGSTFDESPGTNPQATVMMMGRyMGVKILRE 579
Glf COG0562
UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];
1-33 4.51e-07

UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440328 [Multi-domain]  Cd Length: 365  Bit Score: 52.03  E-value: 4.51e-07
                         10        20        30
                 ....*....|....*....|....*....|...
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLE 33
Cdd:COG0562    1 MMYDYLIVGAGFFGAVFAERLAEELGKKVLVID 33
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 3-33 2.32e-04

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 44.07  E-value: 2.32e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 489056897   3 YDYIIVGGGPAGCVLANRLSeDASIKVLLLE 33
Cdd:PTZ00367  34 YDVIIVGGSIAGPVLAKALS-KQGRKVLMLE 63
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 3-33 5.38e-04

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 42.31  E-value: 5.38e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 489056897    3 YDYIIVGGGPAGCVLANRLSeDASIKVLLLE 33
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLA-DKGLRVLLLE 30
COG2509 COG2509
FAD-dependent dehydrogenase [General function prediction only];
1-35 6.36e-04

FAD-dependent dehydrogenase [General function prediction only];


Pssm-ID: 441999 [Multi-domain]  Cd Length: 466  Bit Score: 42.41  E-value: 6.36e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEdASIKVLLLEAG 35
Cdd:COG2509   29 LKYDVVIVGAGPAGLFAALELAE-AGLKPLVLERG 62
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-34 1.20e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 41.28  E-value: 1.20e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEDASIKVLLLEA 34
Cdd:COG0579    3 EMYDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
Lycopene_cycl pfam05834
Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. ...
 4-35 1.72e-03

Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclization of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.


Pssm-ID: 310433 [Multi-domain]  Cd Length: 380  Bit Score: 40.86  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 489056897    4 DYIIVGGGPAGCVLANRLSEDA-SIKVLLLEAG 35
Cdd:pfam05834   1 DVVIIGAGPAGLSLAARLAAAKpGLSVVLIEPG 33
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-262 2.46e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.99  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897    3 YDYIIVGGGPAGCVLANRLSEdASIKVLLLEAGGsdwnplfHMPAGFAKMTKGVASWGWQTVPQKHMKNRVLRYtQAKVI 82
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQ-LGGKVTLIEDEG-------TCPYGGCVLSKALLGAAEAPEIASLWADLYKRK-EEVVK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897   83 GGGSSInaQIYTRGNAADYDL-WA---DEEGCTGWGY-------------RSVLPYFKRAEDNQRFNDDY--HAY----- 138
Cdd:pfam07992  72 KLNNGI--EVLLGTEVVSIDPgAKkvvLEELVDGDGEtitydrlviatgaRPRLPPIPGVELNVGFLVRTldSAEalrlk 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489056897  139 ----------GGPLGVSMPSaplpicdAYIRAGQELGIPYNPDFNGReqagvgfyQLTQRNRRRSSASLAylapirdRRN 208
Cdd:pfam07992 150 llpkrvvvvgGGYIGVELAA-------ALAKLGKEVTLIEALDRLLR--------AFDEEISAALEKALE-------KNG 207

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489056897  209 LTIRMNAQVATIVLEKTRATgVALMSGEVLRASReVIVSSGAIGSPKLLLQSGI 262
Cdd:pfam07992 208 VEVRLGTSVKEIIGDGDGVE-VILKDGTEIDADL-VVVAIGRRPNTELLEAAGL 259
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 1-35 4.03e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 39.68  E-value: 4.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEdASIKVLLLEAG 35
Cdd:COG1249    2 KDYDLVVIGAGPGGYVAAIRAAQ-LGLKVALVEKG 35
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-36 4.50e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 39.50  E-value: 4.50e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSEdASIKVLLLEAGG 36
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLAR-RGLDVTVLERGR 35
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 3-37 5.68e-03

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 39.35  E-value: 5.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 489056897    3 YDYIIVGGGPAGCVLANRLSED---ASIKVLLLEAGGS 37
Cdd:TIGR01989   1 FDVVIVGGGPVGLALAAALGNNpltKDLKVLLLDAVDN 38
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-34 8.15e-03

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 38.38  E-value: 8.15e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 489056897   1 MHYDYIIVGGGPAGCVLANRLSeDASIKVLLLEA 34
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALA-RAGIRVTVVER 34
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-35 8.31e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.20  E-value: 8.31e-03
                          10        20
                  ....*....|....*....|....*....
gi 489056897    7 IVGGGPAGCVLANRLSEdASIKVLLLEAG 35
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK-RGFRVLVLEKR 28
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 4-35 9.33e-03

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 38.34  E-value: 9.33e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 489056897    4 DYIIVGGGPAGCVLANRLSEDaSIKVLLLEAG 35
Cdd:TIGR01988   1 DIVIVGGGMVGLALALALARS-GLKVALIEAT 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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