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Conserved domains on  [gi|489057100|ref|WP_002967223|]
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MULTISPECIES: GntR family transcriptional regulator [Brucella]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
21-252 1.16e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 1.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  21 AGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRisQHLWR 100
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIE--YPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 101 LTSFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRHY---LDQDRVDET 177
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100 178 SLYEALARR-GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDFVAELK 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
21-252 1.16e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 1.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  21 AGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRisQHLWR 100
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIE--YPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 101 LTSFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRHY---LDQDRVDET 177
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100 178 SLYEALARR-GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDFVAELK 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 110-246 1.01e-40

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 136.96  E-value: 1.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  110 SRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRHY---LDQDRVDETSLYEALARR 186
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELvpdLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489057100  187 -GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYD 246
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 110-246 1.07e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 121.63  E-value: 1.07e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100   110 SRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRH----YLDQDRvdETSLYEALAR 185
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAAlfpgLLEEDL--SGSLYEYLEE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489057100   186 R----GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYD 246
Cdd:smart00866  79 RlglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 24-250 1.33e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 106.02  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100   24 LYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERpvRISQHLWRLTS 103
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR--RIDYPLSARTR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  104 FSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAferavVPRHYLDQDRVDET------ 177
Cdd:TIGR02325  87 FSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLC-----RATTWFPAARFPGIgqayaa 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100  178 --SLYEALARRGHKP-VRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDFVAE 250
Cdd:TIGR02325 162 sgSITDALREQGVADyRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
PRK09764 PRK09764
GntR family transcriptional regulator;
23-247 6.40e-27

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 104.14  E-value: 6.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERpvRISQHLWRLT 102
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEE--RVNYDIFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 103 SFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVP-RHYLDQD-RVDETSLY 180
Cdd:PRK09764  83 SFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPlALFPDLTwQVMENSKY 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 181 EALAR-RGHKPVRALQRLTAVTLDPGTAHLLGVHHGAPalLIERVS--HLEDDRIVEYTRSHYRADAYDF 247
Cdd:PRK09764 163 HFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKP--ILEKVSrgYLVDGRVFEYSRNAFNTDDYKF 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-88 8.04e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 85.58  E-value: 8.04e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVA 88
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
21-252 1.16e-75

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.36  E-value: 1.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  21 AGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRisQHLWR 100
Cdd:COG2188    3 PVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIE--YPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 101 LTSFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRHY---LDQDRVDET 177
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100 178 SLYEALARR-GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDFVAELK 252
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 110-246 1.01e-40

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 136.96  E-value: 1.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  110 SRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRHY---LDQDRVDETSLYEALARR 186
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELvpdLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489057100  187 -GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYD 246
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 110-246 1.07e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 121.63  E-value: 1.07e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100   110 SRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRH----YLDQDRvdETSLYEALAR 185
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAAlfpgLLEEDL--SGSLYEYLEE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489057100   186 R----GHKPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYD 246
Cdd:smart00866  79 RlglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 24-250 1.33e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 106.02  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100   24 LYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERpvRISQHLWRLTS 103
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR--RIDYPLSARTR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  104 FSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAferavVPRHYLDQDRVDET------ 177
Cdd:TIGR02325  87 FSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLC-----RATTWFPAARFPGIgqayaa 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100  178 --SLYEALARRGHKP-VRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDFVAE 250
Cdd:TIGR02325 162 sgSITDALREQGVADyRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
PRK09764 PRK09764
GntR family transcriptional regulator;
23-247 6.40e-27

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 104.14  E-value: 6.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERpvRISQHLWRLT 102
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEE--RVNYDIFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 103 SFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFERAVVP-RHYLDQD-RVDETSLY 180
Cdd:PRK09764  83 SFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPlALFPDLTwQVMENSKY 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 181 EALAR-RGHKPVRALQRLTAVTLDPGTAHLLGVHHGAPalLIERVS--HLEDDRIVEYTRSHYRADAYDF 247
Cdd:PRK09764 163 HFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKP--ILEKVSrgYLVDGRVFEYSRNAFNTDDYKF 230
PRK11402 PRK11402
transcriptional regulator PhoB;
23-247 1.14e-24

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 98.37  E-value: 1.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRisQHLWRLT 102
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVE--NALLTVS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 103 SFSQDMISRGKEPGARVVTNriDKPSPDE-AFRLGIGVDASVVRLDRLRLADGVPMAFERAVVPRH---YLDQDRVDETS 178
Cdd:PRK11402  87 GFTDFGVSQGKATKEKVIEQ--ERVSAAPfCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSrypDFDEIYVEGSS 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 179 LYEALARRGH-KPVRALQRLTAVTLDPGTAHLLGVHHGAPALLIERVSHLEDDRIVEYTRSHYRADAYDF 247
Cdd:PRK11402 165 TYQLFQERFDtRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 17-120 3.12e-22

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 94.90  E-value: 3.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  17 DPQLAGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRISQ 96
Cdd:COG1167    6 DRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAP 85

                         90       100
                 ....*....|....*....|....
gi 489057100  97 HLWRLTSFSQDMISRGKEPGARVV 120
Cdd:COG1167   86 APRAAAAVAAPALRRLLEAAPGVI 109
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-88 8.04e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 85.58  E-value: 8.04e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVA 88
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
23-96 1.85e-19

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 80.99  E-value: 1.85e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100  23 PLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRISQ 96
Cdd:COG1725   10 PIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLE 83
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
18-91 1.73e-16

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 76.13  E-value: 1.73e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100  18 PQLAGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERP 91
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPS 75
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 47-250 4.02e-15

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 72.50  E-value: 4.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  47 LPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRISQHlwRLTSFSQDMISRGKEPGARVVTNRIDK 126
Cdd:PRK10079  35 LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLN--AQARFSQNLLDQGSHPTSEKLLSVLRP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 127 PSPDEAFRLGIGVDASVVRLDRLRLADGVPMAferavVPRHYLDQ-------DRVDETSLYEALARRGHKP-VRALQRLT 198
Cdd:PRK10079 113 ASGHVADALGITEGENVIHLRTLRRVNGVALC-----LIDHYFADltwwptlQRFDSGSLHDFLREQLGIAlRRSQTRIS 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489057100 199 AVTLDPGTAHLLGVHHGAPALLIERVSHLED-DRIVEYTRSHYRADAYDFVAE 250
Cdd:PRK10079 188 ARRAQAKESQLLEIPNMSPLLCVRTLNHRDGeSSPAEYSVSLTRADMIEFTME 240
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 24-87 7.45e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 64.56  E-value: 7.45e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100   24 LYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFV 87
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
28-87 1.89e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 63.36  E-value: 1.89e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100    28 LARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFV 87
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 28-98 2.95e-13

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 67.48  E-value: 2.95e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489057100  28 LARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERPVRISQHL 98
Cdd:PRK10421   7 VADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWSEQN 77
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 34-91 7.64e-12

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 64.30  E-value: 7.64e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489057100  34 ELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERP 91
Cdd:PRK15481  16 QLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSP 73
PRK10225 PRK10225
Uxu operon transcriptional regulator;
25-91 4.74e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 58.49  E-value: 4.74e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489057100  25 YRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERP 91
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSS 77
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
32-105 1.36e-09

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 56.95  E-value: 1.36e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100  32 LGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAErpvrisqHLWRltSFS 105
Cdd:PRK09464  19 LEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS-------SLWQ--SFS 83
PRK14999 PRK14999
histidine utilization repressor; Provisional
 15-245 2.09e-09

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 56.48  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  15 LRDPQLAGPLYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAERpvRI 94
Cdd:PRK14999   4 SRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEP--KG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100  95 SQHLWRLTSFSQDMISRGKEPGARVVTNRIDKPSPDEAFRLGIGVDASVVRLDRLRLADGVPMAFE-----RAVVPrHYL 169
Cdd:PRK14999  82 QSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEdrcvnADIAV-DYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489057100 170 DQDRVDET-----SLYEALARRGHKpvralqrLTAVTLDPGTAHLLGVHHGAPALLIERVShLEDDRIVEYTRSHYRADA 244
Cdd:PRK14999 161 TQDYRQTTphaylSRIAPLTEGEHI-------VEAVRATAQECAWLTIKEHEPCLLIRRTT-WSASRIVSHARLLFPGSR 232


                 .
gi 489057100 245 Y 245
Cdd:PRK14999 233 Y 233
PRK11523 PRK11523
transcriptional regulator ExuR;
24-87 1.10e-07

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 51.38  E-value: 1.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100  24 LYRSLARILGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFV 87
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-89 1.81e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 44.53  E-value: 1.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489057100  16 RDPQLAGPLYRSLARILGELIEEGQLAPAVGLPpERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAE 89
Cdd:COG1802    4 PSPLRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 32-96 2.53e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 44.24  E-value: 2.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489057100  32 LGELIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGsgtfvaERPvRISQ 96
Cdd:PRK03837  22 LEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG------ERA-RVSR 79
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 35-89 4.95e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.60  E-value: 4.95e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489057100  35 LIEEGQLAPAVGLPPERDLAEQLGIGRITVRKAYKELLTQGFVESRRGSGTFVAE 89
Cdd:PRK09990  19 LIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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